GREMLIN Database
Q97ZL5 - Uncharacterized protein
UniProt: Q97ZL5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 488 (445)
Sequences: 1802 (951)
Seq/√Len: 45.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
202_Y210_I4.8371.00
28_E57_K4.7821.00
205_K208_S4.7071.00
30_D57_K4.6291.00
21_K28_E4.6191.00
127_S254_D4.2241.00
32_E60_K4.0691.00
402_D405_Q3.9891.00
270_Y301_E3.9601.00
365_K396_Q3.7881.00
129_S307_E3.6711.00
137_D182_E3.3461.00
137_D140_K3.2621.00
36_D145_K3.2451.00
181_N184_E3.2331.00
145_K153_R3.1871.00
164_D201_K3.1781.00
219_D244_R3.1291.00
203_L276_M2.9901.00
17_I68_V2.9261.00
376_M445_G2.9181.00
213_A253_L2.9031.00
25_K76_E2.8101.00
39_I67_I2.7881.00
34_S60_K2.7181.00
209_K273_L2.7101.00
414_V446_I2.7031.00
12_D262_H2.6901.00
43_T69_S2.6611.00
166_E201_K2.5471.00
255_N302_R2.5001.00
278_L294_Y2.4701.00
32_E58_R2.3621.00
35_V61_N2.3341.00
249_D262_H2.3341.00
267_L300_L2.2971.00
21_K57_K2.2901.00
252_E256_Q2.2331.00
209_K272_D2.2301.00
278_L292_A2.1951.00
253_L259_V2.1781.00
18_E21_K2.1451.00
414_V420_V2.1191.00
65_W265_V2.1081.00
170_H258_L2.0971.00
209_K270_Y2.0540.99
171_N236_K2.0240.99
420_V444_L2.0240.99
126_K304_Y1.9850.99
252_E258_L1.9600.99
46_A54_L1.9430.99
216_T312_H1.9360.99
129_S305_I1.9260.99
127_S304_Y1.9140.99
128_P307_E1.9140.99
184_E277_R1.8990.99
130_F254_D1.8830.99
184_E299_K1.8790.99
177_V185_A1.8730.99
65_W309_P1.8590.99
377_M423_I1.8350.99
399_D402_D1.8230.99
139_T182_E1.7910.98
133_E136_L1.7750.98
186_I277_R1.7630.98
139_T179_I1.7430.98
25_K77_S1.7110.98
143_A179_I1.6930.98
270_Y299_K1.6720.98
14_R310_I1.6580.97
342_V378_A1.6450.97
203_L274_N1.6410.97
389_K432_D1.6370.97
68_V71_I1.6360.97
363_S400_V1.6260.97
212_I298_F1.6160.97
275_D299_K1.6140.97
152_G282_F1.6140.97
161_I237_Y1.6070.97
136_L183_K1.6010.97
55_L68_V1.5930.97
138_L185_A1.5880.97
213_A259_V1.5850.97
23_K76_E1.5800.97
79_Y83_G1.5750.96
121_V124_K1.5690.96
206_G209_K1.5580.96
194_R236_K1.5570.96
214_V298_F1.5390.96
132_E302_R1.5240.96
180_L186_I1.5230.96
360_G388_L1.5220.96
253_L258_L1.5210.96
180_L277_R1.5110.96
26_L55_L1.5050.95
230_V239_F1.5030.95
392_I410_I1.4980.95
127_S130_F1.4880.95
55_L310_I1.4730.95
14_R308_D1.4710.95
16_Y81_I1.4660.95
322_E326_I1.4640.95
282_F316_V1.4620.95
362_F379_L1.4580.95
138_L300_L1.4430.94
202_Y211_P1.4320.94
14_R264_E1.4210.94
161_I215_V1.4110.94
422_V444_L1.4010.93
14_R306_R1.4000.93
277_R297_V1.3950.93
33_V42_I1.3870.93
415_D434_S1.3830.93
215_V266_V1.3730.93
19_F23_K1.3660.92
26_L53_P1.3650.92
170_H235_D1.3610.92
10_F19_F1.3200.91
151_A178_Q1.3190.91
155_L216_T1.3000.90
408_Y412_A1.2990.90
256_Q304_Y1.2890.90
416_P442_S1.2820.90
255_N304_Y1.2790.90
19_F80_E1.2750.89
23_K80_E1.2730.89
215_V218_V1.2720.89
417_K424_E1.2690.89
177_V214_V1.2630.89
183_K299_K1.2600.89
131_K305_I1.2590.89
17_I310_I1.2510.89
201_K204_E1.2470.88
144_I313_V1.2450.88
125_A128_P1.2430.88
20_M53_P1.2430.88
390_I416_P1.2420.88
417_K442_S1.2390.88
150_D282_F1.2370.88
359_I411_A1.2360.88
394_V448_A1.2310.88
41_E45_K1.2230.87
380_W445_G1.2100.87
346_I363_S1.2080.87
139_T153_R1.2040.87
185_A298_F1.1960.86
164_D167_T1.1880.86
200_K204_E1.1860.86
272_D275_D1.1860.86
373_K421_W1.1780.85
363_S394_V1.1720.85
136_L182_E1.1720.85
214_V267_L1.1630.85
190_Q290_T1.1620.85
213_A257_L1.1610.84
11_K246_E1.1580.84
183_K267_L1.1530.84
33_V39_I1.1520.84
349_N401_H1.1520.84
61_N64_N1.1330.83
44_R48_Y1.1330.83
370_G440_L1.1330.83
130_F304_Y1.1330.83
162_T195_G1.1270.83
376_M380_W1.1270.83
126_K251_A1.1150.82
141_I265_V1.1100.82
173_S195_G1.1070.82
254_D302_R1.1020.81
253_L304_Y1.1000.81
362_F393_V1.0980.81
405_Q408_Y1.0870.80
300_L303_V1.0820.80
410_I446_I1.0780.80
25_K80_E1.0690.79
180_L184_E1.0690.79
17_I26_L1.0680.79
130_F305_I1.0670.79
265_V305_I1.0600.79
64_N140_K1.0600.79
224_F330_V1.0590.79
187_I298_F1.0570.78
67_I144_I1.0530.78
131_K140_K1.0520.78
200_K203_L1.0510.78
253_L257_L1.0510.78
275_D297_V1.0460.78
219_D222_I1.0450.78
361_I407_I1.0450.78
84_T89_S1.0370.77
211_P270_Y1.0350.77
255_N301_E1.0220.76
267_L303_V1.0210.76
131_K135_N1.0210.76
384_Q387_L1.0150.76
42_I45_K1.0110.75
162_T198_T1.0100.75
364_I393_V1.0100.75
394_V406_V1.0090.75
181_N277_R1.0090.75
85_N89_S1.0080.75
346_I365_K1.0050.75
327_G356_F1.0040.75
117_G120_K1.0010.75
179_I300_L1.0010.75
185_A214_V0.9970.74
196_A200_K0.9960.74
21_K24_G0.9930.74
130_F302_R0.9890.74
409_A412_A0.9890.74
126_K261_S0.9870.73
21_K30_D0.9780.73
95_L339_K0.9770.73
422_V442_S0.9760.73
254_D304_Y0.9730.72
346_I396_Q0.9700.72
157_F312_H0.9680.72
59_V67_I0.9670.72
416_P444_L0.9670.72
314_T317_G0.9640.72
361_I392_I0.9630.72
155_L311_F0.9570.71
159_I172_L0.9510.71
85_N88_E0.9510.71
204_E208_S0.9510.71
392_I448_A0.9450.70
425_N440_L0.9440.70
266_V365_K0.9430.70
423_I445_G0.9430.70
265_V311_F0.9350.69
227_A330_V0.9320.69
19_F22_K0.9290.69
14_R305_I0.9280.69
409_A413_N0.9270.69
213_A266_V0.9210.68
40_A146_T0.9110.67
54_L69_S0.9110.67
33_V40_A0.9080.67
36_D153_R0.9070.67
161_I172_L0.9030.67
155_L158_S0.9010.66
284_D332_R0.8990.66
159_I218_V0.8930.66
163_K211_P0.8920.66
206_G273_L0.8920.66
35_V59_V0.8900.65
163_K256_Q0.8900.65
184_E275_D0.8880.65
197_L201_K0.8860.65
126_K129_S0.8820.65
399_D405_Q0.8790.65
39_I144_I0.8780.64
375_V379_L0.8750.64
126_K263_S0.8740.64
14_R17_I0.8690.64
213_A258_L0.8690.64
229_P322_E0.8650.63
43_T47_T0.8640.63
73_Y77_S0.8630.63
221_A244_R0.8570.63
283_G289_Y0.8490.62
163_K258_L0.8480.62
18_E22_K0.8470.62
345_L348_M0.8460.62
39_I59_V0.8450.61
171_N194_R0.8450.61
132_E135_N0.8440.61
89_S92_E0.8440.61
253_L256_Q0.8380.61
402_D406_V0.8360.61
115_I119_G0.8360.61
39_I69_S0.8350.60
387_L443_K0.8350.60
347_D401_H0.8330.60
95_L98_L0.8320.60
361_I406_V0.8300.60
216_T311_F0.8290.60
113_R117_G0.8290.60
215_V260_P0.8270.60
328_K349_N0.8240.59
257_L260_P0.8230.59
397_D413_N0.8230.59
415_D442_S0.8230.59
74_S77_S0.8200.59
203_L272_D0.8200.59
158_S174_V0.8130.58
218_V267_L0.8110.58
237_Y250_V0.8100.58
27_I31_D0.8100.58
359_I407_I0.8080.58
403_I407_I0.8050.58
132_E254_D0.8000.57
176_R279_E0.8000.57
178_Q281_P0.7990.57
187_I271_V0.7990.57
39_I313_V0.7970.57
295_Y430_S0.7970.57
246_E249_D0.7930.57
347_D400_V0.7930.57
253_L268_T0.7930.57
129_S304_Y0.7930.57
216_T267_L0.7910.56
331_E354_G0.7910.56
17_I365_K0.7900.56
283_G288_Y0.7880.56
162_T173_S0.7870.56
194_R232_H0.7860.56
211_P269_G0.7840.56
272_D299_K0.7840.56
353_Y404_N0.7830.56
327_G431_L0.7830.56
154_Y423_I0.7830.56
342_V375_V0.7830.56
251_A259_V0.7810.55
40_A315_S0.7780.55
309_P312_H0.7770.55
185_A300_L0.7750.55
290_T357_T0.7740.55
318_K405_Q0.7740.55
166_E205_K0.7730.55
209_K301_E0.7720.55
135_N182_E0.7720.55
69_S313_V0.7690.54
372_A381_G0.7670.54
172_L237_Y0.7660.54
111_S114_E0.7650.54
350_L360_G0.7650.54
175_Y189_W0.7650.54
368_Y371_Q0.7640.54
430_S439_P0.7630.54
124_K251_A0.7630.54
95_L99_S0.7620.54
422_V453_K0.7600.53
167_T201_K0.7580.53
362_F375_V0.7580.53
146_T313_V0.7580.53
158_S185_A0.7550.53
161_I253_L0.7540.53
324_A352_E0.7540.53
376_M421_W0.7520.53
264_E306_R0.7490.52
215_V259_V0.7480.52
175_Y195_G0.7460.52
379_L385_L0.7440.52
162_T175_Y0.7430.52
185_A271_V0.7430.52
125_A130_F0.7420.52
78_L326_I0.7420.52
29_V54_L0.7410.51
280_G283_G0.7410.51
211_P256_Q0.7410.51
259_V304_Y0.7390.51
345_L362_F0.7380.51
225_T240_A0.7380.51
160_T177_V0.7350.51
12_D15_E0.7350.51
371_Q452_F0.7350.51
398_I409_A0.7340.51
153_R179_I0.7330.51
159_I222_I0.7330.51
218_V312_H0.7320.51
126_K253_L0.7310.51
34_S38_E0.7300.50
158_S177_V0.7270.50
21_K26_L0.7270.50
149_K289_Y0.7260.50
109_I112_L0.7240.50
59_V396_Q0.7220.50
179_I185_A0.7220.50
92_E96_S0.7220.50
335_L339_K0.7210.50
288_Y431_L0.7210.50
212_I273_L0.7200.49
308_D402_D0.7150.49
405_Q409_A0.7140.49
392_I446_I0.7120.49
34_S61_N0.7110.49
42_I56_F0.7100.48
245_G306_R0.7100.48
361_I394_V0.7070.48
192_F381_G0.7030.48
151_A282_F0.7030.48
120_K124_K0.7020.48
208_S273_L0.6990.47
268_T304_Y0.6990.47
327_G397_D0.6990.47
261_S306_R0.6980.47
407_I410_I0.6970.47
361_I403_I0.6970.47
203_L273_L0.6970.47
376_M391_I0.6960.47
177_V267_L0.6950.47
126_K302_R0.6940.47
382_T391_I0.6920.47
76_E86_K0.6920.47
329_A333_I0.6910.47
209_K274_N0.6900.47
163_K170_H0.6890.46
128_P305_I0.6870.46
366_K452_F0.6860.46
10_F86_K0.6860.46
35_V60_K0.6840.46
177_V198_T0.6830.46
165_P205_K0.6800.46
18_E27_I0.6780.45
323_D326_I0.6770.45
190_Q293_D0.6760.45
377_M421_W0.6760.45
347_D363_S0.6750.45
17_I71_I0.6750.45
164_D168_D0.6720.45
214_V300_L0.6710.45
322_E325_W0.6690.45
251_A261_S0.6690.45
218_V263_S0.6680.44
65_W308_D0.6670.44
156_T282_F0.6620.44
117_G121_V0.6610.44
178_Q280_G0.6600.44
15_E18_E0.6600.44
166_E210_I0.6600.44
14_R18_E0.6580.43
29_V305_I0.6550.43
397_D409_A0.6550.43
198_T210_I0.6550.43
21_K32_E0.6520.43
373_K424_E0.6520.43
136_L267_L0.6520.43
198_T232_H0.6500.43
210_I271_V0.6480.43
64_N422_V0.6480.43
160_T187_I0.6470.42
171_N282_F0.6470.42
22_K31_D0.6460.42
68_V310_I0.6460.42
94_F259_V0.6460.42
35_V273_L0.6450.42
321_L326_I0.6450.42
216_T265_V0.6440.42
147_W188_H0.6440.42
152_G317_G0.6420.42
53_P68_V0.6420.42
175_Y322_E0.6420.42
421_W445_G0.6410.42
30_D58_R0.6410.42
379_L391_I0.6390.42
109_I114_E0.6370.41
12_D17_I0.6370.41
169_V233_G0.6360.41
194_R198_T0.6350.41
373_K376_M0.6350.41
31_D41_E0.6350.41
306_R309_P0.6350.41
359_I390_I0.6340.41
331_E335_L0.6320.41
405_Q412_A0.6320.41
134_K182_E0.6310.41
395_D447_D0.6300.41
39_I56_F0.6290.41
24_G31_D0.6290.41
354_G425_N0.6280.41
53_P80_E0.6280.41
188_H387_L0.6270.41
100_N111_S0.6240.40
405_Q444_L0.6240.40
32_E59_V0.6220.40
175_Y283_G0.6210.40
124_K284_D0.6210.40
107_D111_S0.6210.40
35_V62_Y0.6210.40
245_G249_D0.6200.40
27_I54_L0.6190.40
40_A144_I0.6180.40
147_W322_E0.6180.40
158_S328_K0.6180.40
286_M355_L0.6170.40
147_W316_V0.6160.39
251_A260_P0.6160.39
125_A262_H0.6160.39
361_I400_V0.6150.39
389_K434_S0.6130.39
160_T212_I0.6130.39
128_P304_Y0.6110.39
70_N147_W0.6110.39
251_A304_Y0.6090.39
431_L443_K0.6090.39
120_K123_P0.6090.39
40_A313_V0.6070.39
88_E92_E0.6060.39
118_L121_V0.6060.39
353_Y407_I0.6050.38
19_F83_G0.6040.38
52_P74_S0.6030.38
126_K256_Q0.6010.38
126_K255_N0.6000.38
285_H429_D0.5980.38
303_V447_D0.5980.38
110_K113_R0.5980.38
141_I303_V0.5970.38
128_P261_S0.5960.38
188_H357_T0.5950.38
359_I392_I0.5930.37
330_V357_T0.5930.37
202_Y303_V0.5920.37
111_S115_I0.5920.37
121_V242_I0.5920.37
193_K325_W0.5910.37
37_L296_P0.5900.37
120_K263_S0.5880.37
165_P201_K0.5880.37
190_Q385_L0.5870.37
16_Y286_M0.5870.37
428_T433_P0.5860.37
213_A269_G0.5860.37
190_Q358_G0.5850.37
22_K30_D0.5840.37
188_H290_T0.5840.37
140_K299_K0.5820.36
68_V452_F0.5810.36
198_T202_Y0.5800.36
74_S172_L0.5800.36
285_H323_D0.5800.36
17_I22_K0.5780.36
136_L140_K0.5780.36
390_I444_L0.5770.36
43_T48_Y0.5770.36
118_L123_P0.5760.36
349_N352_E0.5750.36
338_A378_A0.5750.36
67_I313_V0.5750.36
263_S304_Y0.5750.36
141_I309_P0.5740.36
29_V42_I0.5740.36
203_L275_D0.5730.36
188_H284_D0.5730.36
96_S99_S0.5730.36
222_I442_S0.5730.36
423_I426_A0.5720.35
211_P253_L0.5720.35
11_K15_E0.5700.35
342_V377_M0.5700.35
32_E62_Y0.5690.35
401_H461_P0.5690.35
82_F221_A0.5690.35
41_E46_A0.5680.35
450_R456_M0.5670.35
51_L77_S0.5670.35
29_V204_E0.5670.35
310_I373_K0.5670.35
256_Q301_E0.5670.35
90_I94_F0.5670.35
379_L383_G0.5660.35
160_T250_V0.5640.35
316_V357_T0.5620.35
29_V32_E0.5620.35
348_M371_Q0.5610.35
31_D266_V0.5610.35
236_K279_E0.5610.35
373_K445_G0.5590.34
133_E302_R0.5580.34
278_L293_D0.5560.34
256_Q302_R0.5560.34
202_Y276_M0.5550.34
229_P357_T0.5550.34
46_A51_L0.5540.34
124_K443_K0.5540.34
24_G396_Q0.5530.34
128_P306_R0.5520.34
114_E119_G0.5520.34
59_V62_Y0.5500.34
152_G236_K0.5490.33
136_L139_T0.5480.33
27_I52_P0.5480.33
350_L355_L0.5470.33
147_W283_G0.5470.33
35_V144_I0.5470.33
24_G307_E0.5460.33
179_I267_L0.5460.33
131_K134_K0.5440.33
24_G206_G0.5440.33
43_T46_A0.5430.33
228_S330_V0.5430.33
171_N175_Y0.5430.33
373_K423_I0.5430.33
137_D183_K0.5420.33
15_E21_K0.5410.33
319_P322_E0.5410.33
213_A255_N0.5410.33
113_R116_L0.5410.33
370_G374_R0.5410.33
431_L434_S0.5400.33
33_V56_F0.5400.33
127_S302_R0.5400.33
108_K119_G0.5400.33
259_V266_V0.5380.33
166_E169_V0.5380.33
283_G322_E0.5380.33
34_S226_A0.5370.32
430_S433_P0.5370.32
191_A391_I0.5370.32
284_D443_K0.5350.32
125_A261_S0.5350.32
366_K395_D0.5340.32
175_Y321_L0.5330.32
193_K284_D0.5330.32
256_Q391_I0.5330.32
130_F261_S0.5330.32
136_L303_V0.5320.32
435_V441_G0.5320.32
190_Q357_T0.5310.32
28_E32_E0.5300.32
18_E30_D0.5300.32
40_A69_S0.5290.32
277_R439_P0.5290.32
10_F15_E0.5290.32
224_F227_A0.5280.32
206_G274_N0.5280.32
89_S256_Q0.5270.32
24_G42_I0.5270.32
290_T381_G0.5260.31
413_N450_R0.5260.31
29_V402_D0.5260.31
155_L179_I0.5250.31
179_I303_V0.5250.31
144_I311_F0.5240.31
148_P177_V0.5240.31
91_S95_L0.5240.31
290_T293_D0.5240.31
116_L120_K0.5240.31
219_D262_H0.5240.31
370_G427_L0.5230.31
211_P255_N0.5230.31
273_L276_M0.5230.31
415_D418_R0.5220.31
157_F316_V0.5210.31
267_L298_F0.5180.31
171_N279_E0.5170.31
190_Q193_K0.5170.31
22_K155_L0.5170.31
191_A387_L0.5160.31
24_G52_P0.5160.31
230_V236_K0.5150.31
174_V357_T0.5130.30
126_K254_D0.5120.30
203_L209_K0.5120.30
263_S422_V0.5120.30
151_A280_G0.5100.30
338_A371_Q0.5090.30
423_I444_L0.5090.30
135_N179_I0.5080.30
408_Y458_K0.5080.30
124_K249_D0.5080.30
172_L228_S0.5060.30
229_P287_G0.5060.30
392_I406_V0.5050.30
244_R249_D0.5050.30
364_I367_Y0.5050.30
268_T301_E0.5050.30
178_Q283_G0.5050.30
375_V391_I0.5030.30
57_K66_K0.5030.30
394_V446_I0.5020.30
201_K205_K0.5020.30
116_L119_G0.5020.30
17_I42_I0.5020.30
284_D288_Y0.5010.29
225_T228_S0.5010.29
271_V400_V0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2idbA 3 0.9529 100 0.084 Contact Map
4ip2A 2 0.9611 100 0.118 Contact Map
4za9A 2 0.957 100 0.145 Contact Map
4zacA 2 0.9611 100 0.146 Contact Map
4zadA 2 0.9549 100 0.147 Contact Map
2cyyA 2 0.252 41.2 0.977 Contact Map
2p5vA 5 0.2602 40.4 0.977 Contact Map
3i4pA 5 0.2582 37.6 0.978 Contact Map
2e1cA 1 0.25 37.1 0.978 Contact Map
4lvnP 1 0.0738 32.9 0.978 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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