GREMLIN Database
Q97ZL3 - Uncharacterized protein
UniProt: Q97ZL3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 221 (200)
Sequences: 116 (89)
Seq/√Len: 6.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
106_A195_E3.6410.91
68_F190_A3.2180.84
57_I96_I2.9180.78
120_L155_L2.6430.70
113_R145_M2.4450.64
52_R148_I2.3220.60
79_D194_A2.3110.59
86_Y117_I2.2800.58
82_R183_A2.1720.54
182_E194_A2.1690.54
193_V197_R2.1360.53
74_S79_D2.1200.52
56_Y92_E2.0660.50
12_N209_V2.0300.49
17_Q51_S1.9900.48
63_R100_L1.9740.47
83_A87_A1.9650.47
92_E109_Q1.9220.45
184_R188_E1.8880.44
122_D145_M1.8680.43
75_Q86_Y1.8290.42
114_L190_A1.8230.42
67_L194_A1.7900.40
96_I159_L1.7550.39
199_K206_P1.7380.39
92_E113_R1.7260.38
68_F114_L1.6890.37
14_G23_E1.6740.36
120_L131_L1.6660.36
113_R203_P1.6300.35
24_R135_K1.6250.35
16_K20_S1.6130.34
47_R111_Q1.5830.33
60_L84_A1.5630.33
19_P23_E1.5520.32
119_E162_V1.5370.32
12_N16_K1.5170.31
32_Q52_R1.5110.31
151_E202_F1.4860.30
133_V199_K1.4790.30
64_D94_R1.4770.30
89_E146_P1.4560.29
127_L137_L1.4560.29
90_I125_N1.4540.29
107_L182_E1.4510.29
74_S193_V1.4490.29
63_R138_R1.4490.29
123_V134_I1.4290.29
100_L155_L1.4170.28
161_E165_E1.4100.28
27_N187_L1.4060.28
84_A163_V1.4030.28
75_Q130_V1.3700.27
16_K21_I1.3590.27
46_L107_L1.3470.26
38_R59_R1.3440.26
96_I134_I1.3340.26
42_A59_R1.3210.26
80_T187_L1.3130.25
20_S23_E1.2980.25
83_A134_I1.2920.25
157_E197_R1.2860.25
12_N17_Q1.2860.25
110_V124_F1.2790.24
133_V147_E1.2750.24
52_R187_L1.2670.24
120_L135_K1.2650.24
185_K194_A1.2630.24
77_S137_L1.2600.24
35_L75_Q1.2540.24
93_I152_L1.2360.23
131_L179_S1.2320.23
124_F128_I1.2260.23
17_Q21_I1.2240.23
127_L185_K1.2090.23
152_L196_Q1.2080.23
88_N179_S1.2080.23
49_M103_T1.2070.22
177_G180_S1.2050.22
106_A197_R1.1930.22
113_R122_D1.1880.22
130_V167_G1.1860.22
98_R106_A1.1850.22
16_K24_R1.1530.21
64_D195_E1.1410.21
133_V158_G1.1400.21
83_A86_Y1.1300.21
16_K22_G1.1280.21
81_A162_V1.1280.21
88_N182_E1.1260.20
105_I197_R1.1260.20
31_P150_L1.1240.20
32_Q183_A1.1050.20
185_K198_M1.1040.20
132_G205_L1.1030.20
54_D191_S1.0900.20
14_G22_G1.0850.20
98_R205_L1.0790.19
36_R113_R1.0780.19
64_D98_R1.0760.19
55_V157_E1.0750.19
112_L115_E1.0740.19
12_N26_K1.0660.19
43_N156_E1.0530.19
67_L126_S1.0530.19
17_Q22_G1.0510.19
55_V197_R1.0410.19
134_I148_I1.0400.19
146_P189_E1.0370.18
89_E189_E1.0370.18
83_A199_K1.0280.18
53_L145_M1.0220.18
60_L121_G1.0180.18
75_Q165_E1.0140.18
39_L52_R1.0100.18
14_G17_Q1.0090.18
133_V200_E1.0030.18
134_I155_L1.0010.18
52_R80_T0.9930.18
60_L70_K0.9830.17
42_A99_Q0.9750.17
164_I204_E0.9750.17
22_G28_A0.9710.17
159_L193_V0.9680.17
25_I191_S0.9670.17
38_R153_A0.9630.17
121_G134_I0.9610.17
11_K14_G0.9460.17
62_E98_R0.9450.17
186_I203_P0.9420.16
147_E162_V0.9380.16
69_E198_M0.9320.16
110_V181_P0.9240.16
147_E200_E0.9220.16
95_K112_L0.9220.16
37_Y78_K0.9100.16
49_M99_Q0.9080.16
86_Y143_G0.9060.16
116_T206_P0.8960.16
71_V84_A0.8960.16
80_T98_R0.8960.16
147_E152_L0.8940.16
172_A197_R0.8860.15
25_I207_S0.8860.15
67_L79_D0.8790.15
76_M184_R0.8750.15
79_D129_P0.8690.15
127_L187_L0.8670.15
46_L116_T0.8660.15
20_S46_L0.8630.15
86_Y115_E0.8570.15
19_P25_I0.8570.15
166_A198_M0.8560.15
113_R180_S0.8510.15
41_M90_I0.8410.15
24_R144_V0.8350.14
175_N207_S0.8340.14
21_I30_K0.8330.14
152_L183_A0.8310.14
134_I181_P0.8270.14
102_T148_I0.8250.14
76_M82_R0.8250.14
96_I115_E0.8150.14
63_R152_L0.8120.14
103_T137_L0.8070.14
61_Q145_M0.8050.14
87_A144_V0.8050.14
131_L165_E0.8010.14
147_E167_G0.7930.14
53_L117_I0.7870.14
34_P133_V0.7870.14
77_S145_M0.7870.14
49_M129_P0.7840.14
94_R116_T0.7800.13
90_I140_A0.7780.13
36_R125_N0.7750.13
17_Q24_R0.7740.13
27_N36_R0.7710.13
122_D151_E0.7700.13
129_P203_P0.7690.13
87_A187_L0.7640.13
20_S41_M0.7600.13
80_T87_A0.7580.13
129_P148_I0.7540.13
124_F186_I0.7540.13
36_R180_S0.7500.13
120_L186_I0.7470.13
30_K38_R0.7440.13
145_M160_Q0.7440.13
91_A202_F0.7420.13
20_S24_R0.7330.13
64_D182_E0.7330.13
31_P135_K0.7260.13
75_Q80_T0.7260.13
67_L115_E0.7160.12
124_F159_L0.7110.12
101_I201_K0.7090.12
152_L182_E0.7070.12
65_R143_G0.7040.12
23_E210_T0.6940.12
87_A149_S0.6940.12
104_Q122_D0.6910.12
26_K71_V0.6900.12
46_L160_Q0.6900.12
28_A65_R0.6870.12
44_Y124_F0.6850.12
20_S135_K0.6850.12
29_F131_L0.6830.12
30_K131_L0.6800.12
27_N123_V0.6780.12
51_S144_V0.6770.12
182_E191_S0.6760.12
20_S28_A0.6670.12
42_A95_K0.6670.12
110_V123_V0.6660.12
64_D194_A0.6660.12
21_I25_I0.6650.12
88_N116_T0.6620.12
57_I104_Q0.6590.12
25_I164_I0.6570.12
23_E29_F0.6560.12
177_G210_T0.6520.11
79_D182_E0.6470.11
85_M198_M0.6460.11
101_I202_F0.6440.11
12_N21_I0.6390.11
25_I28_A0.6360.11
110_V117_I0.6320.11
18_E43_N0.6310.11
38_R68_F0.6200.11
31_P145_M0.6150.11
20_S25_I0.6130.11
49_M130_V0.6090.11
136_E182_E0.6000.11
46_L81_A0.5970.11
62_E82_R0.5910.11
41_M125_N0.5910.11
123_V155_L0.5890.11
121_G159_L0.5890.11
45_R74_S0.5890.11
115_E133_V0.5880.11
60_L74_S0.5870.11
41_M138_R0.5870.11
83_A186_I0.5870.11
123_V195_E0.5850.10
94_R112_L0.5840.10
33_Q118_T0.5820.10
87_A146_P0.5800.10
12_N27_N0.5790.10
71_V173_P0.5750.10
69_E199_K0.5750.10
176_Y209_V0.5740.10
14_G20_S0.5740.10
96_I173_P0.5730.10
51_S171_G0.5710.10
70_K203_P0.5690.10
44_Y119_E0.5690.10
39_L94_R0.5670.10
77_S209_V0.5670.10
95_K120_L0.5660.10
82_R180_S0.5660.10
55_V179_S0.5660.10
112_L190_A0.5660.10
98_R198_M0.5640.10
43_N93_I0.5630.10
52_R175_N0.5570.10
70_K74_S0.5540.10
77_S181_P0.5530.10
67_L180_S0.5530.10
39_L116_T0.5520.10
127_L203_P0.5430.10
61_Q171_G0.5420.10
56_Y113_R0.5410.10
136_E150_L0.5400.10
199_K204_E0.5400.10
151_E194_A0.5380.10
103_T136_E0.5380.10
100_L164_I0.5370.10
129_P167_G0.5360.10
22_G208_F0.5340.10
50_V125_N0.5340.10
31_P103_T0.5320.10
98_R194_A0.5300.10
68_F122_D0.5270.10
78_K149_S0.5250.10
16_K19_P0.5250.10
39_L211_S0.5230.10
82_R163_V0.5200.10
123_V204_E0.5200.10
119_E134_I0.5150.10
155_L166_A0.5130.10
95_K131_L0.5110.10
55_V178_A0.5060.09
70_K109_Q0.5050.09
50_V188_E0.5050.09
86_Y205_L0.5050.09
56_Y99_Q0.5050.09
129_P186_I0.5030.09
45_R54_D0.5010.09
106_A110_V0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gd5A 2 0.7104 99.7 0.742 Contact Map
3frtA 1 0.6199 99.7 0.757 Contact Map
4abmA 2 0.3258 58.5 0.946 Contact Map
4uxvA 1 0.8688 34.3 0.953 Contact Map
4nqiA 2 0.6561 9.8 0.964 Contact Map
4ecgA 1 0.3891 9.1 0.964 Contact Map
2ocyA 4 0.552 8.4 0.965 Contact Map
1pehA 1 0.1493 7.9 0.965 Contact Map
3viqB 1 0.3801 7.8 0.965 Contact Map
2kk7A 1 0.2353 7.4 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0075 seconds.