GREMLIN Database
Q97ZL1 - Uncharacterized protein
UniProt: Q97ZL1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 360 (345)
Sequences: 968 (471)
Seq/√Len: 25.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
138_E142_R4.7061.00
119_D123_S3.9891.00
173_N176_K3.6541.00
154_A317_V3.6511.00
212_E285_S3.6271.00
196_F296_A3.5151.00
21_I51_V3.3821.00
20_G287_F3.1831.00
173_N177_E3.1681.00
22_E25_K3.0971.00
21_I50_V2.9131.00
146_N174_K2.7830.99
153_T180_L2.7650.99
179_N326_G2.7610.99
10_L18_I2.7530.99
141_T159_I2.7170.99
129_L153_T2.6340.99
285_S289_G2.6250.99
202_S206_L2.6080.99
52_A89_V2.5720.99
34_G37_T2.5390.99
154_A321_L2.5370.99
145_A155_F2.4910.99
6_A52_A2.4470.99
114_L151_A2.3740.98
4_R125_K2.3370.98
60_K63_K2.3260.98
352_R356_E2.3050.98
93_P98_V2.2990.98
34_G38_P2.2480.98
211_V282_V2.1700.97
91_A144_Y2.1530.97
275_T299_E2.1220.97
200_I296_A2.0840.96
317_V329_L2.0310.96
8_A129_L2.0210.95
130_V156_I2.0020.95
5_V51_V2.0010.95
50_V65_L1.9550.94
219_V272_L1.9400.94
154_A180_L1.9060.94
150_M174_K1.9000.94
311_V315_R1.8760.93
80_V84_K1.8690.93
90_S120_E1.8670.93
156_I317_V1.8560.93
180_L321_L1.8510.93
118_L151_A1.8450.93
63_K67_E1.8410.92
349_E352_R1.8370.92
146_N150_M1.8370.92
23_Y289_G1.8360.92
278_A282_V1.7970.92
158_A310_L1.7800.91
19_Q71_Q1.7730.91
172_P328_P1.7610.91
66_A85_K1.7170.90
164_A182_L1.7040.89
3_I48_I1.6980.89
15_S58_K1.6890.89
275_T301_D1.6880.89
349_E353_W1.6670.88
91_A94_V1.6470.87
332_V354_F1.6470.87
219_V279_Y1.6330.87
142_R166_D1.6320.87
200_I204_F1.6250.87
222_N303_K1.6090.86
277_V286_A1.5970.86
332_V336_Y1.5900.85
286_A292_I1.5610.84
196_F294_V1.5550.84
158_A187_I1.5420.84
274_N303_K1.5230.83
113_T148_A1.5130.82
224_D276_K1.5000.82
18_I51_V1.4680.80
284_G292_I1.4680.80
218_N224_D1.4670.80
287_F296_A1.4530.80
131_N141_T1.4520.80
243_E339_H1.4480.80
218_N276_K1.4320.79
35_L38_P1.4150.78
94_V109_T1.4150.78
330_E342_I1.4070.78
10_L86_G1.4010.77
7_I10_L1.3970.77
271_F283_K1.3890.77
277_V297_S1.3860.76
215_Y269_V1.3850.76
107_N110_Y1.3840.76
22_E83_E1.3730.76
148_A153_T1.3680.75
295_E299_E1.3630.75
33_E38_P1.3600.75
6_A126_A1.3600.75
26_S82_M1.3350.74
18_I21_I1.3220.73
148_A336_Y1.3120.72
210_K285_S1.2960.71
316_A336_Y1.2930.71
62_G80_V1.2870.71
129_L148_A1.2760.70
199_S203_L1.2740.70
6_A89_V1.2730.70
207_R335_F1.2720.70
181_P320_A1.2710.70
199_S351_Y1.2680.70
105_V108_P1.2660.70
195_I203_L1.2650.69
120_E123_S1.2540.69
196_F200_I1.2500.69
8_A147_I1.2460.68
135_V228_M1.2410.68
279_Y297_S1.2340.68
130_V158_A1.2320.67
24_Y45_I1.2300.67
244_A248_T1.2280.67
139_N142_R1.2260.67
157_N185_D1.2240.67
320_A329_L1.2160.66
204_F294_V1.2040.66
350_A354_F1.1920.65
86_G92_G1.1900.65
104_N226_L1.1890.65
8_A135_V1.1710.63
217_L269_V1.1620.63
132_L306_C1.1610.63
37_T355_K1.1610.63
329_L332_V1.1580.62
32_Y38_P1.1560.62
64_D86_G1.1510.62
60_K84_K1.1510.62
325_I331_K1.1400.61
99_A230_T1.1390.61
5_V21_I1.1370.61
343_Q346_D1.1270.60
133_L159_I1.1160.60
143_T147_I1.1160.60
121_L129_L1.1030.59
89_V92_G1.1020.59
22_E26_S1.0920.58
249_L336_Y1.0900.58
183_A337_F1.0730.56
5_V50_V1.0590.55
309_V336_Y1.0590.55
44_K122_K1.0570.55
40_I316_A1.0570.55
5_V314_I1.0560.55
100_Q232_E1.0390.54
111_D118_L1.0390.54
240_S339_H1.0350.54
277_V293_K1.0340.54
236_S239_I1.0290.53
114_L147_I1.0250.53
201_T249_L1.0230.53
21_I311_V1.0210.53
107_N111_D1.0210.53
114_L118_L1.0190.53
115_E119_D1.0150.52
115_E177_E1.0080.52
127_E321_L0.9880.50
86_G89_V0.9880.50
222_N274_N0.9800.50
351_Y354_F0.9800.50
122_K177_E0.9790.50
137_S225_F0.9750.49
119_D179_N0.9730.49
110_Y114_L0.9720.49
209_V284_G0.9710.49
20_G320_A0.9690.49
183_A332_V0.9640.49
191_L286_A0.9630.48
23_Y75_I0.9630.48
228_M266_S0.9560.48
93_P117_A0.9540.48
5_V17_L0.9500.48
165_S185_D0.9450.47
133_L161_V0.9430.47
281_Y295_E0.9420.47
51_V126_A0.9410.47
205_R259_G0.9380.47
355_K358_I0.9370.47
51_V215_Y0.9330.46
354_F357_F0.9290.46
172_P176_K0.9280.46
224_D228_M0.9260.46
60_K121_L0.9240.46
7_I134_P0.9230.46
193_A296_A0.9230.46
122_K178_K0.9220.46
133_L157_N0.9180.45
143_T288_A0.9130.45
15_S73_P0.9080.44
95_L144_Y0.9030.44
31_Y289_G0.9020.44
145_A167_P0.8980.44
112_G115_E0.8970.44
124_S127_E0.8960.44
147_I286_A0.8950.44
105_V109_T0.8890.43
118_L147_I0.8890.43
3_I156_I0.8890.43
219_V297_S0.8840.43
277_V299_E0.8840.43
128_I154_A0.8830.43
27_K38_P0.8810.43
176_K326_G0.8790.42
228_M276_K0.8790.42
272_L279_Y0.8770.42
211_V249_L0.8730.42
5_V80_V0.8730.42
225_F306_C0.8720.42
155_F164_A0.8720.42
81_N167_P0.8700.42
87_V179_N0.8690.42
271_F295_E0.8660.41
8_A131_N0.8650.41
201_T282_V0.8570.41
336_Y354_F0.8560.41
179_N289_G0.8560.41
95_L140_A0.8540.41
15_S70_F0.8500.40
228_M264_G0.8470.40
263_I287_F0.8430.40
94_V113_T0.8370.39
167_P289_G0.8340.39
306_C313_V0.8340.39
148_A171_F0.8320.39
34_G39_V0.8320.39
75_I288_A0.8320.39
313_V337_F0.8310.39
74_N314_I0.8280.39
93_P114_L0.8270.39
113_T116_K0.8250.39
37_T316_A0.8190.38
25_K82_M0.8180.38
215_Y283_K0.8170.38
133_L216_Q0.8170.38
191_L292_I0.8170.38
148_A180_L0.8140.38
90_S115_E0.8140.38
157_N182_L0.8130.38
128_I321_L0.8120.38
99_A102_M0.8100.38
277_V301_D0.8100.38
286_A290_M0.8090.38
236_S240_S0.8090.38
250_D257_S0.8080.37
66_A177_E0.8080.37
33_E37_T0.8020.37
218_N228_M0.8020.37
202_S249_L0.8000.37
53_A87_V0.7980.37
234_L238_R0.7920.36
3_I126_A0.7920.36
246_T261_I0.7830.36
219_V278_A0.7820.36
77_P349_E0.7810.36
119_D122_K0.7810.36
4_R127_E0.7780.35
204_F284_G0.7740.35
286_A301_D0.7710.35
4_R121_L0.7710.35
126_A129_L0.7710.35
44_K47_D0.7710.35
95_L102_M0.7710.35
59_N314_I0.7700.35
22_E82_M0.7700.35
52_A124_S0.7670.35
94_V108_P0.7640.34
39_V42_G0.7620.34
272_L297_S0.7600.34
58_K178_K0.7600.34
278_A306_C0.7590.34
248_T260_K0.7590.34
181_P307_A0.7580.34
325_I329_L0.7530.34
228_M234_L0.7520.34
132_L314_I0.7510.34
234_L262_R0.7500.34
256_K260_K0.7490.34
25_K118_L0.7490.34
129_L180_L0.7420.33
100_Q211_V0.7410.33
81_N179_N0.7380.33
130_V317_V0.7370.33
33_E36_I0.7370.33
206_L351_Y0.7350.33
92_G151_A0.7350.33
88_K120_E0.7340.33
144_Y157_N0.7340.33
91_A101_H0.7330.32
4_R126_A0.7310.32
119_D173_N0.7290.32
47_D240_S0.7260.32
240_S275_T0.7210.32
43_Y322_D0.7200.32
245_V260_K0.7140.31
82_M89_V0.7130.31
47_D123_S0.7120.31
287_F320_A0.7110.31
119_D124_S0.7110.31
351_Y358_I0.7090.31
112_G116_K0.7080.31
46_T111_D0.7070.31
26_S58_K0.7060.31
21_I177_E0.7060.31
168_S174_K0.7050.31
50_V124_S0.7020.31
173_N324_K0.6970.30
324_K327_G0.6950.30
111_D114_L0.6900.30
37_T243_E0.6890.30
77_P80_V0.6870.30
308_A337_F0.6870.30
149_L178_K0.6860.30
309_V332_V0.6840.29
199_S292_I0.6840.29
92_G144_Y0.6810.29
75_I101_H0.6800.29
343_Q347_D0.6780.29
301_D339_H0.6760.29
118_L122_K0.6740.29
115_E120_E0.6720.29
317_V321_L0.6720.29
307_A336_Y0.6710.29
24_Y35_L0.6700.29
225_F266_S0.6690.29
75_I78_K0.6670.28
157_N165_S0.6650.28
13_C306_C0.6640.28
13_C16_M0.6620.28
56_V285_S0.6600.28
219_V248_T0.6600.28
60_K149_L0.6600.28
200_I297_S0.6580.28
150_M178_K0.6580.28
325_I357_F0.6570.28
167_P204_F0.6570.28
15_S59_N0.6560.28
128_I317_V0.6540.28
128_I178_K0.6510.27
230_T280_I0.6510.27
218_N340_P0.6490.27
22_E354_F0.6490.27
135_V165_S0.6470.27
320_A331_K0.6460.27
270_P293_K0.6450.27
20_G181_P0.6430.27
17_L309_V0.6430.27
156_I209_V0.6420.27
306_C311_V0.6410.27
351_Y355_K0.6410.27
65_L83_E0.6390.27
84_K122_K0.6390.27
320_A327_G0.6380.27
25_K155_F0.6360.27
37_T44_K0.6350.27
3_I347_D0.6340.26
236_S242_T0.6310.26
144_Y148_A0.6300.26
283_K295_E0.6270.26
213_E260_K0.6240.26
130_V236_S0.6240.26
156_I178_K0.6240.26
137_S280_I0.6220.26
72_P96_D0.6190.26
137_S306_C0.6150.25
111_D179_N0.6130.25
83_E89_V0.6120.25
27_K33_E0.6110.25
232_E356_E0.6100.25
25_K29_D0.6100.25
223_T226_L0.6080.25
316_A332_V0.6060.25
149_L179_N0.6050.25
279_Y292_I0.6040.25
181_P327_G0.6040.25
164_A323_R0.6000.25
202_S277_V0.5980.24
3_I43_Y0.5980.24
215_Y295_E0.5960.24
131_N159_I0.5950.24
208_G291_P0.5950.24
94_V99_A0.5940.24
266_S306_C0.5940.24
183_A317_V0.5930.24
266_S280_I0.5930.24
288_A337_F0.5930.24
120_E141_T0.5930.24
204_F296_A0.5910.24
205_R349_E0.5910.24
98_V102_M0.5910.24
4_R142_R0.5910.24
141_T258_E0.5890.24
287_F337_F0.5880.24
56_V112_G0.5870.24
197_H216_Q0.5840.24
114_L150_M0.5820.24
142_R171_F0.5820.24
225_F280_I0.5810.24
286_A293_K0.5800.24
204_F282_V0.5800.24
343_Q357_F0.5800.24
293_K299_E0.5770.23
26_S122_K0.5770.23
225_F265_P0.5750.23
320_A325_I0.5740.23
202_S310_L0.5720.23
73_P77_P0.5720.23
93_P111_D0.5710.23
55_D60_K0.5700.23
132_L309_V0.5690.23
92_G315_R0.5680.23
146_N171_F0.5670.23
147_I158_A0.5670.23
202_S286_A0.5670.23
305_N308_A0.5650.23
53_A61_I0.5650.23
8_A93_P0.5630.23
180_L323_R0.5620.23
177_E352_R0.5600.22
301_D304_A0.5600.22
27_K289_G0.5590.22
218_N240_S0.5590.22
46_T84_K0.5570.22
30_N176_K0.5560.22
306_C337_F0.5550.22
92_G97_G0.5530.22
19_Q60_K0.5530.22
262_R269_V0.5520.22
52_A287_F0.5500.22
66_A84_K0.5490.22
319_V358_I0.5480.22
236_S262_R0.5450.22
162_F228_M0.5450.22
50_V85_K0.5450.22
281_Y297_S0.5450.22
94_V144_Y0.5440.22
148_A151_A0.5440.22
181_P329_L0.5440.22
352_R355_K0.5400.21
319_V322_D0.5380.21
21_I296_A0.5380.21
318_K322_D0.5380.21
40_I87_V0.5380.21
224_D240_S0.5370.21
178_K353_W0.5370.21
101_H339_H0.5360.21
288_A342_I0.5350.21
202_S294_V0.5350.21
122_K173_N0.5350.21
110_Y115_E0.5340.21
89_V119_D0.5320.21
272_L299_E0.5320.21
132_L308_A0.5320.21
135_V234_L0.5310.21
70_F223_T0.5290.21
78_K176_K0.5290.21
202_S354_F0.5280.21
116_K138_E0.5280.21
135_V162_F0.5270.21
287_F307_A0.5270.21
185_D208_G0.5270.21
28_G31_Y0.5270.21
238_R262_R0.5260.21
23_Y288_A0.5260.21
190_Q266_S0.5260.21
20_G316_A0.5250.21
17_L37_T0.5250.21
56_V210_K0.5250.21
118_L127_E0.5240.21
220_G225_F0.5240.21
112_G148_A0.5230.21
251_N256_K0.5220.21
285_S291_P0.5210.21
182_L358_I0.5210.21
148_A152_G0.5200.21
176_K324_K0.5200.21
302_D338_K0.5200.21
52_A126_A0.5200.21
205_R250_D0.5200.21
213_E283_K0.5180.20
126_A323_R0.5180.20
307_A327_G0.5170.20
274_N304_A0.5170.20
51_V130_V0.5130.20
3_I57_S0.5130.20
193_A262_R0.5130.20
4_R58_K0.5120.20
36_I39_V0.5120.20
225_F276_K0.5110.20
100_Q196_F0.5100.20
155_F183_A0.5090.20
93_P100_Q0.5090.20
17_L21_I0.5070.20
233_R337_F0.5070.20
60_K86_G0.5070.20
35_L39_V0.5070.20
141_T145_A0.5070.20
27_K40_I0.5060.20
227_N233_R0.5050.20
201_T256_K0.5050.20
225_F278_A0.5050.20
268_Y274_N0.5040.20
154_A164_A0.5040.20
262_R267_D0.5040.20
66_A80_V0.5040.20
249_L282_V0.5030.20
152_G178_K0.5030.20
145_A166_D0.5020.20
55_D160_P0.5010.20
235_I239_I0.5010.20
230_T275_T0.5000.20
154_A182_L0.5000.20
120_E280_I0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cinA 3 0.9583 100 0.174 Contact Map
1vkoA 4 0.9806 100 0.182 Contact Map
1p1jA 4 0.9806 100 0.182 Contact Map
1gr0A 3 0.9083 100 0.183 Contact Map
3qvsA 2 0.9444 100 0.201 Contact Map
3bioA 4 0.7444 98 0.931 Contact Map
1f06A 2 0.7472 97.9 0.933 Contact Map
4pg7A 2 0.7111 97.9 0.933 Contact Map
3ingA 2 0.725 97.9 0.934 Contact Map
2g0tA 3 0.7833 97.8 0.935 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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