Q97ZL1 - SULSO - GREMLIN Contacts

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Q97ZL1 - Uncharacterized protein

UniProt:	Q97ZL1	Sequences: MMIRVAIAGLGNCASMLIQGIEYYKSKGDNYYEGLITPVIGGYKITDIEVVAAFDVSKNKIGKDLAEAVFQPPNITPKIVNMEKKGVKVSAGPVLDGVAQHMTNVFNPTYDGTLEKALDELKSSKAEILVNLLPVGSENATRTYANIALMAGTAFINAIPVFIASDPSGYFPNKFKEKNLPLAGDDIKSQLGATIFHRSITSLFRLRGVKVEETYQLNVGGNTDFLNMKTEERLISKRISKTEAVTSTLDNGEVIKSEGKIRIGPSDYVPFLGNTKVAYIYVKGSAFAGMPIKVEASLEVDDKANCAAVLVDVIRAVKVALDRKIGGPLEKVSAFYFKHPPIQAKDDEEAYRWFKEFIEM	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	360 (345)
Sequences:	968 (471)
Seq/√Len:	25.4

SULSO - Q97ZL1 Q980G7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
138_E	142_R	4.706	1.00
119_D	123_S	3.989	1.00
173_N	176_K	3.654	1.00
154_A	317_V	3.651	1.00
212_E	285_S	3.627	1.00
196_F	296_A	3.515	1.00
21_I	51_V	3.382	1.00
20_G	287_F	3.183	1.00
173_N	177_E	3.168	1.00
22_E	25_K	3.097	1.00
21_I	50_V	2.913	1.00
146_N	174_K	2.783	0.99
153_T	180_L	2.765	0.99
179_N	326_G	2.761	0.99
10_L	18_I	2.753	0.99
141_T	159_I	2.717	0.99
129_L	153_T	2.634	0.99
285_S	289_G	2.625	0.99
202_S	206_L	2.608	0.99
52_A	89_V	2.572	0.99
34_G	37_T	2.539	0.99
154_A	321_L	2.537	0.99
145_A	155_F	2.491	0.99
6_A	52_A	2.447	0.99
114_L	151_A	2.374	0.98
4_R	125_K	2.337	0.98
60_K	63_K	2.326	0.98
352_R	356_E	2.305	0.98
93_P	98_V	2.299	0.98
34_G	38_P	2.248	0.98
211_V	282_V	2.170	0.97
91_A	144_Y	2.153	0.97
275_T	299_E	2.122	0.97
200_I	296_A	2.084	0.96
317_V	329_L	2.031	0.96
8_A	129_L	2.021	0.95
130_V	156_I	2.002	0.95
5_V	51_V	2.001	0.95
50_V	65_L	1.955	0.94
219_V	272_L	1.940	0.94
154_A	180_L	1.906	0.94
150_M	174_K	1.900	0.94
311_V	315_R	1.876	0.93
80_V	84_K	1.869	0.93
90_S	120_E	1.867	0.93
156_I	317_V	1.856	0.93
180_L	321_L	1.851	0.93
118_L	151_A	1.845	0.93
63_K	67_E	1.841	0.92
349_E	352_R	1.837	0.92
146_N	150_M	1.837	0.92
23_Y	289_G	1.836	0.92
278_A	282_V	1.797	0.92
158_A	310_L	1.780	0.91
19_Q	71_Q	1.773	0.91
172_P	328_P	1.761	0.91
66_A	85_K	1.717	0.90
164_A	182_L	1.704	0.89
3_I	48_I	1.698	0.89
15_S	58_K	1.689	0.89
275_T	301_D	1.688	0.89
349_E	353_W	1.667	0.88
91_A	94_V	1.647	0.87
332_V	354_F	1.647	0.87
219_V	279_Y	1.633	0.87
142_R	166_D	1.632	0.87
200_I	204_F	1.625	0.87
222_N	303_K	1.609	0.86
277_V	286_A	1.597	0.86
332_V	336_Y	1.590	0.85
286_A	292_I	1.561	0.84
196_F	294_V	1.555	0.84
158_A	187_I	1.542	0.84
274_N	303_K	1.523	0.83
113_T	148_A	1.513	0.82
224_D	276_K	1.500	0.82
18_I	51_V	1.468	0.80
284_G	292_I	1.468	0.80
218_N	224_D	1.467	0.80
287_F	296_A	1.453	0.80
131_N	141_T	1.452	0.80
243_E	339_H	1.448	0.80
218_N	276_K	1.432	0.79
35_L	38_P	1.415	0.78
94_V	109_T	1.415	0.78
330_E	342_I	1.407	0.78
10_L	86_G	1.401	0.77
7_I	10_L	1.397	0.77
271_F	283_K	1.389	0.77
277_V	297_S	1.386	0.76
215_Y	269_V	1.385	0.76
107_N	110_Y	1.384	0.76
22_E	83_E	1.373	0.76
148_A	153_T	1.368	0.75
295_E	299_E	1.363	0.75
33_E	38_P	1.360	0.75
6_A	126_A	1.360	0.75
26_S	82_M	1.335	0.74
18_I	21_I	1.322	0.73
148_A	336_Y	1.312	0.72
210_K	285_S	1.296	0.71
316_A	336_Y	1.293	0.71
62_G	80_V	1.287	0.71
129_L	148_A	1.276	0.70
199_S	203_L	1.274	0.70
6_A	89_V	1.273	0.70
207_R	335_F	1.272	0.70
181_P	320_A	1.271	0.70
199_S	351_Y	1.268	0.70
105_V	108_P	1.266	0.70
195_I	203_L	1.265	0.69
120_E	123_S	1.254	0.69
196_F	200_I	1.250	0.69
8_A	147_I	1.246	0.68
135_V	228_M	1.241	0.68
279_Y	297_S	1.234	0.68
130_V	158_A	1.232	0.67
24_Y	45_I	1.230	0.67
244_A	248_T	1.228	0.67
139_N	142_R	1.226	0.67
157_N	185_D	1.224	0.67
320_A	329_L	1.216	0.66
204_F	294_V	1.204	0.66
350_A	354_F	1.192	0.65
86_G	92_G	1.190	0.65
104_N	226_L	1.189	0.65
8_A	135_V	1.171	0.63
217_L	269_V	1.162	0.63
132_L	306_C	1.161	0.63
37_T	355_K	1.161	0.63
329_L	332_V	1.158	0.62
32_Y	38_P	1.156	0.62
64_D	86_G	1.151	0.62
60_K	84_K	1.151	0.62
325_I	331_K	1.140	0.61
99_A	230_T	1.139	0.61
5_V	21_I	1.137	0.61
343_Q	346_D	1.127	0.60
133_L	159_I	1.116	0.60
143_T	147_I	1.116	0.60
121_L	129_L	1.103	0.59
89_V	92_G	1.102	0.59
22_E	26_S	1.092	0.58
249_L	336_Y	1.090	0.58
183_A	337_F	1.073	0.56
5_V	50_V	1.059	0.55
309_V	336_Y	1.059	0.55
44_K	122_K	1.057	0.55
40_I	316_A	1.057	0.55
5_V	314_I	1.056	0.55
100_Q	232_E	1.039	0.54
111_D	118_L	1.039	0.54
240_S	339_H	1.035	0.54
277_V	293_K	1.034	0.54
236_S	239_I	1.029	0.53
114_L	147_I	1.025	0.53
201_T	249_L	1.023	0.53
21_I	311_V	1.021	0.53
107_N	111_D	1.021	0.53
114_L	118_L	1.019	0.53
115_E	119_D	1.015	0.52
115_E	177_E	1.008	0.52
127_E	321_L	0.988	0.50
86_G	89_V	0.988	0.50
222_N	274_N	0.980	0.50
351_Y	354_F	0.980	0.50
122_K	177_E	0.979	0.50
137_S	225_F	0.975	0.49
119_D	179_N	0.973	0.49
110_Y	114_L	0.972	0.49
209_V	284_G	0.971	0.49
20_G	320_A	0.969	0.49
183_A	332_V	0.964	0.49
191_L	286_A	0.963	0.48
23_Y	75_I	0.963	0.48
228_M	266_S	0.956	0.48
93_P	117_A	0.954	0.48
5_V	17_L	0.950	0.48
165_S	185_D	0.945	0.47
133_L	161_V	0.943	0.47
281_Y	295_E	0.942	0.47
51_V	126_A	0.941	0.47
205_R	259_G	0.938	0.47
355_K	358_I	0.937	0.47
51_V	215_Y	0.933	0.46
354_F	357_F	0.929	0.46
172_P	176_K	0.928	0.46
224_D	228_M	0.926	0.46
60_K	121_L	0.924	0.46
7_I	134_P	0.923	0.46
193_A	296_A	0.923	0.46
122_K	178_K	0.922	0.46
133_L	157_N	0.918	0.45
143_T	288_A	0.913	0.45
15_S	73_P	0.908	0.44
95_L	144_Y	0.903	0.44
31_Y	289_G	0.902	0.44
145_A	167_P	0.898	0.44
112_G	115_E	0.897	0.44
124_S	127_E	0.896	0.44
147_I	286_A	0.895	0.44
105_V	109_T	0.889	0.43
118_L	147_I	0.889	0.43
3_I	156_I	0.889	0.43
219_V	297_S	0.884	0.43
277_V	299_E	0.884	0.43
128_I	154_A	0.883	0.43
27_K	38_P	0.881	0.43
176_K	326_G	0.879	0.42
228_M	276_K	0.879	0.42
272_L	279_Y	0.877	0.42
211_V	249_L	0.873	0.42
5_V	80_V	0.873	0.42
225_F	306_C	0.872	0.42
155_F	164_A	0.872	0.42
81_N	167_P	0.870	0.42
87_V	179_N	0.869	0.42
271_F	295_E	0.866	0.41
8_A	131_N	0.865	0.41
201_T	282_V	0.857	0.41
336_Y	354_F	0.856	0.41
179_N	289_G	0.856	0.41
95_L	140_A	0.854	0.41
15_S	70_F	0.850	0.40
228_M	264_G	0.847	0.40
263_I	287_F	0.843	0.40
94_V	113_T	0.837	0.39
167_P	289_G	0.834	0.39
306_C	313_V	0.834	0.39
148_A	171_F	0.832	0.39
34_G	39_V	0.832	0.39
75_I	288_A	0.832	0.39
313_V	337_F	0.831	0.39
74_N	314_I	0.828	0.39
93_P	114_L	0.827	0.39
113_T	116_K	0.825	0.39
37_T	316_A	0.819	0.38
25_K	82_M	0.818	0.38
215_Y	283_K	0.817	0.38
133_L	216_Q	0.817	0.38
191_L	292_I	0.817	0.38
148_A	180_L	0.814	0.38
90_S	115_E	0.814	0.38
157_N	182_L	0.813	0.38
128_I	321_L	0.812	0.38
99_A	102_M	0.810	0.38
277_V	301_D	0.810	0.38
286_A	290_M	0.809	0.38
236_S	240_S	0.809	0.38
250_D	257_S	0.808	0.37
66_A	177_E	0.808	0.37
33_E	37_T	0.802	0.37
218_N	228_M	0.802	0.37
202_S	249_L	0.800	0.37
53_A	87_V	0.798	0.37
234_L	238_R	0.792	0.36
3_I	126_A	0.792	0.36
246_T	261_I	0.783	0.36
219_V	278_A	0.782	0.36
77_P	349_E	0.781	0.36
119_D	122_K	0.781	0.36
4_R	127_E	0.778	0.35
204_F	284_G	0.774	0.35
286_A	301_D	0.771	0.35
4_R	121_L	0.771	0.35
126_A	129_L	0.771	0.35
44_K	47_D	0.771	0.35
95_L	102_M	0.771	0.35
59_N	314_I	0.770	0.35
22_E	82_M	0.770	0.35
52_A	124_S	0.767	0.35
94_V	108_P	0.764	0.34
39_V	42_G	0.762	0.34
272_L	297_S	0.760	0.34
58_K	178_K	0.760	0.34
278_A	306_C	0.759	0.34
248_T	260_K	0.759	0.34
181_P	307_A	0.758	0.34
325_I	329_L	0.753	0.34
228_M	234_L	0.752	0.34
132_L	314_I	0.751	0.34
234_L	262_R	0.750	0.34
256_K	260_K	0.749	0.34
25_K	118_L	0.749	0.34
129_L	180_L	0.742	0.33
100_Q	211_V	0.741	0.33
81_N	179_N	0.738	0.33
130_V	317_V	0.737	0.33
33_E	36_I	0.737	0.33
206_L	351_Y	0.735	0.33
92_G	151_A	0.735	0.33
88_K	120_E	0.734	0.33
144_Y	157_N	0.734	0.33
91_A	101_H	0.733	0.32
4_R	126_A	0.731	0.32
119_D	173_N	0.729	0.32
47_D	240_S	0.726	0.32
240_S	275_T	0.721	0.32
43_Y	322_D	0.720	0.32
245_V	260_K	0.714	0.31
82_M	89_V	0.713	0.31
47_D	123_S	0.712	0.31
287_F	320_A	0.711	0.31
119_D	124_S	0.711	0.31
351_Y	358_I	0.709	0.31
112_G	116_K	0.708	0.31
46_T	111_D	0.707	0.31
26_S	58_K	0.706	0.31
21_I	177_E	0.706	0.31
168_S	174_K	0.705	0.31
50_V	124_S	0.702	0.31
173_N	324_K	0.697	0.30
324_K	327_G	0.695	0.30
111_D	114_L	0.690	0.30
37_T	243_E	0.689	0.30
77_P	80_V	0.687	0.30
308_A	337_F	0.687	0.30
149_L	178_K	0.686	0.30
309_V	332_V	0.684	0.29
199_S	292_I	0.684	0.29
92_G	144_Y	0.681	0.29
75_I	101_H	0.680	0.29
343_Q	347_D	0.678	0.29
301_D	339_H	0.676	0.29
118_L	122_K	0.674	0.29
115_E	120_E	0.672	0.29
317_V	321_L	0.672	0.29
307_A	336_Y	0.671	0.29
24_Y	35_L	0.670	0.29
225_F	266_S	0.669	0.29
75_I	78_K	0.667	0.28
157_N	165_S	0.665	0.28
13_C	306_C	0.664	0.28
13_C	16_M	0.662	0.28
56_V	285_S	0.660	0.28
219_V	248_T	0.660	0.28
60_K	149_L	0.660	0.28
200_I	297_S	0.658	0.28
150_M	178_K	0.658	0.28
325_I	357_F	0.657	0.28
167_P	204_F	0.657	0.28
15_S	59_N	0.656	0.28
128_I	317_V	0.654	0.28
128_I	178_K	0.651	0.27
230_T	280_I	0.651	0.27
218_N	340_P	0.649	0.27
22_E	354_F	0.649	0.27
135_V	165_S	0.647	0.27
320_A	331_K	0.646	0.27
270_P	293_K	0.645	0.27
20_G	181_P	0.643	0.27
17_L	309_V	0.643	0.27
156_I	209_V	0.642	0.27
306_C	311_V	0.641	0.27
351_Y	355_K	0.641	0.27
65_L	83_E	0.639	0.27
84_K	122_K	0.639	0.27
320_A	327_G	0.638	0.27
25_K	155_F	0.636	0.27
37_T	44_K	0.635	0.27
3_I	347_D	0.634	0.26
236_S	242_T	0.631	0.26
144_Y	148_A	0.630	0.26
283_K	295_E	0.627	0.26
213_E	260_K	0.624	0.26
130_V	236_S	0.624	0.26
156_I	178_K	0.624	0.26
137_S	280_I	0.622	0.26
72_P	96_D	0.619	0.26
137_S	306_C	0.615	0.25
111_D	179_N	0.613	0.25
83_E	89_V	0.612	0.25
27_K	33_E	0.611	0.25
232_E	356_E	0.610	0.25
25_K	29_D	0.610	0.25
223_T	226_L	0.608	0.25
316_A	332_V	0.606	0.25
149_L	179_N	0.605	0.25
279_Y	292_I	0.604	0.25
181_P	327_G	0.604	0.25
164_A	323_R	0.600	0.25
202_S	277_V	0.598	0.24
3_I	43_Y	0.598	0.24
215_Y	295_E	0.596	0.24
131_N	159_I	0.595	0.24
208_G	291_P	0.595	0.24
94_V	99_A	0.594	0.24
266_S	306_C	0.594	0.24
183_A	317_V	0.593	0.24
266_S	280_I	0.593	0.24
288_A	337_F	0.593	0.24
120_E	141_T	0.593	0.24
204_F	296_A	0.591	0.24
205_R	349_E	0.591	0.24
98_V	102_M	0.591	0.24
4_R	142_R	0.591	0.24
141_T	258_E	0.589	0.24
287_F	337_F	0.588	0.24
56_V	112_G	0.587	0.24
197_H	216_Q	0.584	0.24
114_L	150_M	0.582	0.24
142_R	171_F	0.582	0.24
225_F	280_I	0.581	0.24
286_A	293_K	0.580	0.24
204_F	282_V	0.580	0.24
343_Q	357_F	0.580	0.24
293_K	299_E	0.577	0.23
26_S	122_K	0.577	0.23
225_F	265_P	0.575	0.23
320_A	325_I	0.574	0.23
202_S	310_L	0.572	0.23
73_P	77_P	0.572	0.23
93_P	111_D	0.571	0.23
55_D	60_K	0.570	0.23
132_L	309_V	0.569	0.23
92_G	315_R	0.568	0.23
146_N	171_F	0.567	0.23
147_I	158_A	0.567	0.23
202_S	286_A	0.567	0.23
305_N	308_A	0.565	0.23
53_A	61_I	0.565	0.23
8_A	93_P	0.563	0.23
180_L	323_R	0.562	0.23
177_E	352_R	0.560	0.22
301_D	304_A	0.560	0.22
27_K	289_G	0.559	0.22
218_N	240_S	0.559	0.22
46_T	84_K	0.557	0.22
30_N	176_K	0.556	0.22
306_C	337_F	0.555	0.22
92_G	97_G	0.553	0.22
19_Q	60_K	0.553	0.22
262_R	269_V	0.552	0.22
52_A	287_F	0.550	0.22
66_A	84_K	0.549	0.22
319_V	358_I	0.548	0.22
236_S	262_R	0.545	0.22
162_F	228_M	0.545	0.22
50_V	85_K	0.545	0.22
281_Y	297_S	0.545	0.22
94_V	144_Y	0.544	0.22
148_A	151_A	0.544	0.22
181_P	329_L	0.544	0.22
352_R	355_K	0.540	0.21
319_V	322_D	0.538	0.21
21_I	296_A	0.538	0.21
318_K	322_D	0.538	0.21
40_I	87_V	0.538	0.21
224_D	240_S	0.537	0.21
178_K	353_W	0.537	0.21
101_H	339_H	0.536	0.21
288_A	342_I	0.535	0.21
202_S	294_V	0.535	0.21
122_K	173_N	0.535	0.21
110_Y	115_E	0.534	0.21
89_V	119_D	0.532	0.21
272_L	299_E	0.532	0.21
132_L	308_A	0.532	0.21
135_V	234_L	0.531	0.21
70_F	223_T	0.529	0.21
78_K	176_K	0.529	0.21
202_S	354_F	0.528	0.21
116_K	138_E	0.528	0.21
135_V	162_F	0.527	0.21
287_F	307_A	0.527	0.21
185_D	208_G	0.527	0.21
28_G	31_Y	0.527	0.21
238_R	262_R	0.526	0.21
23_Y	288_A	0.526	0.21
190_Q	266_S	0.526	0.21
20_G	316_A	0.525	0.21
17_L	37_T	0.525	0.21
56_V	210_K	0.525	0.21
118_L	127_E	0.524	0.21
220_G	225_F	0.524	0.21
112_G	148_A	0.523	0.21
251_N	256_K	0.522	0.21
285_S	291_P	0.521	0.21
182_L	358_I	0.521	0.21
148_A	152_G	0.520	0.21
176_K	324_K	0.520	0.21
302_D	338_K	0.520	0.21
52_A	126_A	0.520	0.21
205_R	250_D	0.520	0.21
213_E	283_K	0.518	0.20
126_A	323_R	0.518	0.20
307_A	327_G	0.517	0.20
274_N	304_A	0.517	0.20
51_V	130_V	0.513	0.20
3_I	57_S	0.513	0.20
193_A	262_R	0.513	0.20
4_R	58_K	0.512	0.20
36_I	39_V	0.512	0.20
225_F	276_K	0.511	0.20
100_Q	196_F	0.510	0.20
155_F	183_A	0.509	0.20
93_P	100_Q	0.509	0.20
17_L	21_I	0.507	0.20
233_R	337_F	0.507	0.20
60_K	86_G	0.507	0.20
35_L	39_V	0.507	0.20
141_T	145_A	0.507	0.20
27_K	40_I	0.506	0.20
227_N	233_R	0.505	0.20
201_T	256_K	0.505	0.20
225_F	278_A	0.505	0.20
268_Y	274_N	0.504	0.20
154_A	164_A	0.504	0.20
262_R	267_D	0.504	0.20
66_A	80_V	0.504	0.20
249_L	282_V	0.503	0.20
152_G	178_K	0.503	0.20
145_A	166_D	0.502	0.20
55_D	160_P	0.501	0.20
235_I	239_I	0.501	0.20
230_T	275_T	0.500	0.20
154_A	182_L	0.500	0.20
120_E	280_I	0.500	0.20

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3cinA	3	0.9583	100	0.174	Contact Map
1vkoA	4	0.9806	100	0.182	Contact Map
1p1jA	4	0.9806	100	0.182	Contact Map
1gr0A	3	0.9083	100	0.183	Contact Map
3qvsA	2	0.9444	100	0.201	Contact Map
3bioA	4	0.7444	98	0.931	Contact Map
1f06A	2	0.7472	97.9	0.933	Contact Map
4pg7A	2	0.7111	97.9	0.933	Contact Map
3ingA	2	0.725	97.9	0.934	Contact Map
2g0tA	3	0.7833	97.8	0.935	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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