GREMLIN Database
ACYP - Acylphosphatase
UniProt: Q97ZL0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 101 (85)
Sequences: 2158 (1669)
Seq/√Len: 181.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_F71_R2.8231.00
58_A68_L2.7291.00
19_R53_S2.6411.00
36_H39_R2.5021.00
28_G31_K2.3521.00
15_R59_E2.2391.00
21_Y53_S2.2371.00
21_Y83_K2.1791.00
59_E93_G2.0921.00
49_L55_E2.0911.00
15_R57_V1.7401.00
18_A72_I1.6591.00
18_A69_L1.6451.00
17_Y55_E1.6211.00
34_Q38_I1.6061.00
76_P79_A1.5251.00
49_L53_S1.4681.00
56_V72_I1.4331.00
14_K65_L1.4301.00
18_A58_A1.4231.00
18_A56_V1.4181.00
16_M88_F1.3981.00
43_K97_D1.3441.00
33_V68_L1.3231.00
18_A86_Y1.3211.00
62_E66_S1.3111.00
69_L86_Y1.2871.00
14_K62_E1.2821.00
33_V72_I1.2381.00
58_A72_I1.2261.00
14_K88_F1.1691.00
15_R95_F1.1451.00
47_K55_E1.1301.00
75_G79_A1.1251.00
31_K35_I1.1241.00
17_Y89_S1.1151.00
17_Y45_Y1.1141.00
36_H71_R1.1081.00
31_K34_Q1.1041.00
46_A56_V1.0801.00
21_Y85_D1.0501.00
61_Y64_A1.0371.00
66_S70_E1.0291.00
64_A67_K1.0220.99
20_V72_I1.0110.99
16_M86_Y1.0010.99
40_L68_L1.0000.99
40_L67_K0.9540.99
58_A65_L0.9530.99
36_H40_L0.9470.99
40_L71_R0.9460.99
42_I60_G0.9430.99
57_V89_S0.9350.99
16_M65_L0.9330.99
28_G32_F0.9250.99
33_V58_A0.9120.99
69_L73_K0.8860.99
16_M69_L0.8860.99
73_K84_V0.8730.98
57_V95_F0.8710.98
28_G78_A0.8550.98
20_V84_V0.8470.98
20_V56_V0.8470.98
59_E92_K0.8370.98
62_E88_F0.8330.98
45_Y57_V0.8230.98
45_Y55_E0.8170.98
91_Y95_F0.8060.97
29_F72_I0.7980.97
95_F99_E0.7870.97
70_E73_K0.7860.97
45_Y56_V0.7790.97
28_G77_P0.7780.97
56_V68_L0.7710.96
19_R49_L0.7710.96
19_R55_E0.7660.96
43_K95_F0.7600.96
33_V71_R0.7550.96
92_K95_F0.7410.96
67_K70_E0.7380.95
42_I58_A0.7350.95
59_E91_Y0.7350.95
17_Y87_S0.7150.95
32_F36_H0.7150.95
15_R89_S0.7130.95
40_L64_A0.7100.94
23_L80_E0.7060.94
19_R85_D0.6950.94
60_G64_A0.6920.94
16_M58_A0.6790.93
59_E95_F0.6740.93
33_V46_A0.6650.92
35_I38_I0.6650.92
28_G35_I0.6620.92
67_K71_R0.6540.92
41_G64_A0.6540.92
32_F79_A0.6380.91
18_A84_V0.6380.91
34_Q46_A0.6350.90
43_K59_E0.6320.90
23_L28_G0.6160.89
17_Y46_A0.6160.89
96_E99_E0.6110.89
61_Y96_E0.6050.88
74_Q79_A0.5950.87
45_Y49_L0.5930.87
73_K86_Y0.5840.86
14_K66_S0.5810.86
24_V54_V0.5810.86
64_A68_L0.5750.86
17_Y57_V0.5680.85
28_G72_I0.5640.84
57_V92_K0.5590.84
62_E96_E0.5550.83
38_I97_D0.5540.83
71_R74_Q0.5460.83
45_Y75_G0.5420.82
65_L69_L0.5370.81
42_I61_Y0.5330.81
33_V56_V0.5300.81
29_F33_V0.5280.80
19_R51_D0.5280.80
29_F40_L0.5250.80
32_F76_P0.5240.80
38_I90_E0.5140.79
70_E74_Q0.5080.78
20_V76_P0.5070.78
39_R63_E0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2bjdA 1 0.8911 100 0.193 Contact Map
3trgA 1 0.9208 100 0.259 Contact Map
2fhmA 1 0.8812 100 0.259 Contact Map
4hi1A 3 0.8713 100 0.259 Contact Map
2lxfA 1 0.9802 100 0.262 Contact Map
4g9iA 1 0.8713 100 0.263 Contact Map
2gv1A 1 0.901 100 0.265 Contact Map
1ulrA 1 0.8614 100 0.267 Contact Map
1w2iA 2 0.8812 100 0.27 Contact Map
1urrA 1 0.9208 100 0.278 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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