GREMLIN Database
Q97ZK8 - Uncharacterized protein
UniProt: Q97ZK8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 331 (277)
Sequences: 25485 (19349)
Seq/√Len: 1162.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
4_A110_F4.2511.00
11_A232_S4.0191.00
257_L261_E3.4461.00
2_R25_E3.2031.00
22_I244_H3.1611.00
29_F108_K3.0671.00
2_R111_D3.0671.00
18_L240_F2.9061.00
15_L114_I2.8801.00
4_A29_F2.8501.00
178_K182_N2.7701.00
17_Y96_S2.5911.00
11_A214_I2.5271.00
115_D123_D2.4591.00
242_A259_I2.3741.00
91_N95_K2.3311.00
242_A255_E2.2301.00
14_T233_A2.1991.00
100_I107_A2.1831.00
50_P237_E2.0511.00
261_E265_K2.0471.00
47_Y230_R2.0431.00
24_Y244_H2.0421.00
236_A240_F2.0151.00
115_D213_R2.0111.00
182_N186_R1.9991.00
100_I109_E1.9781.00
116_S214_I1.8631.00
98_K109_E1.8531.00
238_Y259_I1.7931.00
16_A28_I1.7861.00
184_Y188_R1.7841.00
17_Y21_R1.7681.00
238_Y242_A1.7511.00
122_M126_V1.7491.00
27_T108_K1.7371.00
248_D251_G1.7371.00
3_I19_L1.7341.00
15_L236_A1.7151.00
53_W237_E1.7121.00
102_T107_A1.7021.00
2_R27_T1.6911.00
127_V211_K1.6881.00
3_I24_Y1.6841.00
117_R121_P1.6351.00
114_I214_I1.6221.00
180_L183_Y1.6111.00
112_Y253_L1.6091.00
29_F103_H1.5891.00
103_H108_K1.5841.00
179_E182_N1.5821.00
235_S260_I1.5801.00
179_E183_Y1.5661.00
197_I200_A1.5531.00
212_L239_A1.5531.00
185_L188_R1.5521.00
234_I263_R1.5261.00
10_V229_I1.5241.00
4_A108_K1.5141.00
183_Y186_R1.5131.00
181_L185_L1.5131.00
4_A101_V1.5051.00
103_H106_N1.5031.00
242_A252_F1.4741.00
194_V197_I1.4521.00
180_L184_Y1.4451.00
183_Y187_K1.3961.00
242_A245_K1.3851.00
102_T105_N1.3831.00
114_I212_L1.3811.00
241_E259_I1.3621.00
119_P220_L1.3611.00
17_Y97_S1.3401.00
132_A135_E1.3321.00
16_A26_V1.3161.00
15_L19_L1.3141.00
219_G235_S1.3101.00
122_M125_E1.2911.00
129_T133_I1.2891.00
47_Y233_A1.2881.00
128_Y131_R1.2871.00
200_A205_G1.2831.00
70_K73_D1.2831.00
8_G13_S1.2771.00
69_E72_Y1.2731.00
5_I15_L1.2731.00
88_K91_N1.2621.00
4_A27_T1.2461.00
85_D88_K1.2451.00
6_L123_D1.2291.00
200_A203_S1.2231.00
130_T133_I1.2211.00
181_L184_Y1.2071.00
135_E138_E1.2001.00
133_I136_T1.1891.00
13_S97_S1.1821.00
59_I62_F1.1801.00
178_K181_L1.1791.00
207_V212_L1.1701.00
130_T134_I1.1591.00
129_T137_E1.1591.00
14_T18_L1.1561.00
221_V268_K1.1521.00
189_F194_V1.1521.00
197_I201_P1.1471.00
6_L117_R1.1371.00
254_N258_S1.1341.00
27_T110_F1.1311.00
110_F113_V1.1291.00
156_W168_G1.1251.00
20_S26_V1.1221.00
265_K269_M1.1181.00
5_I16_A1.1181.00
221_V231_P1.1061.00
238_Y241_E1.1021.00
6_L113_V1.0971.00
15_L214_I1.0961.00
200_A204_I1.0961.00
41_D229_I1.0941.00
214_I256_K1.0881.00
18_L22_I1.0871.00
98_K103_H1.0741.00
213_R217_A1.0731.00
92_D95_K1.0701.00
166_N170_G1.0611.00
178_K185_L1.0521.00
92_D96_S1.0501.00
201_P205_G1.0381.00
53_W241_E1.0381.00
20_S97_S1.0351.00
178_K188_R1.0341.00
23_N26_V1.0341.00
181_L188_R1.0311.00
21_R96_S1.0311.00
245_K255_E1.0231.00
198_R201_P1.0201.00
207_V257_L1.0201.00
255_E258_S1.0171.00
128_Y132_A1.0101.00
86_K90_I1.0101.00
250_D254_N1.0071.00
131_R135_E1.0061.00
59_I64_F1.0031.00
5_I26_V0.9991.00
10_V233_A0.9941.00
2_R24_Y0.9891.00
199_G204_I0.9851.00
182_N185_L0.9831.00
19_L24_Y0.9811.00
197_I205_G0.9701.00
41_D86_K0.9691.00
18_L21_R0.9671.00
212_L256_K0.9591.00
136_T139_F0.9581.00
199_G203_S0.9541.00
129_T132_A0.9521.00
225_S271_L0.9481.00
90_I94_R0.9421.00
130_T135_E0.9381.00
137_E140_D0.9381.00
61_R144_I0.9351.00
129_T136_T0.9261.00
130_T136_T0.9211.00
38_P41_D0.9191.00
99_V103_H0.9181.00
131_R139_F0.9131.00
208_K254_N0.9101.00
237_E241_E0.9051.00
198_R203_S0.9051.00
202_I205_G0.9041.00
121_P124_R0.9031.00
128_Y133_I0.9031.00
19_L240_F0.9031.00
99_V210_K0.9021.00
181_L186_R0.8981.00
66_I70_K0.8951.00
249_L253_L0.8941.00
134_I137_E0.8911.00
115_D211_K0.8901.00
46_I227_E0.8871.00
48_T82_L0.8851.00
192_F195_K0.8841.00
13_S90_I0.8781.00
49_P52_N0.8741.00
18_L237_E0.8711.00
129_T135_E0.8711.00
13_S94_R0.8711.00
221_V225_S0.8701.00
167_I170_G0.8691.00
262_K266_I0.8671.00
26_V97_S0.8661.00
46_I49_P0.8651.00
16_A97_S0.8631.00
184_Y187_K0.8621.00
115_D121_P0.8591.00
29_F110_F0.8571.00
255_E259_I0.8541.00
112_Y212_L0.8481.00
201_P204_I0.8461.00
123_D211_K0.8421.00
240_F244_H0.8401.00
272_D276_Y0.8321.00
213_R218_R0.8301.00
42_I81_W0.8301.00
191_N194_V0.8301.00
46_I234_I0.8291.00
29_F101_V0.8271.00
204_I272_D0.8261.00
47_Y50_P0.8231.00
19_L243_I0.8211.00
209_N250_D0.8171.00
22_I240_F0.8171.00
199_G202_I0.8151.00
99_V113_V0.8151.00
249_L252_F0.8081.00
136_T140_D0.8071.00
166_N171_F0.8061.00
8_G30_D0.8061.00
143_A146_E0.8051.00
14_T93_M0.8051.00
259_I262_K0.8041.00
48_T52_N0.8041.00
63_S73_D0.8031.00
61_R73_D0.8021.00
51_F233_A0.7971.00
220_L235_S0.7951.00
150_R153_G0.7941.00
114_I239_A0.7931.00
208_K212_L0.7931.00
129_T134_I0.7921.00
248_D252_F0.7921.00
167_I171_F0.7871.00
143_A148_N0.7821.00
229_I232_S0.7781.00
63_S66_I0.7731.00
2_R108_K0.7721.00
203_S206_S0.7691.00
131_R134_I0.7641.00
132_A136_T0.7581.00
198_R202_I0.7571.00
85_D161_K0.7541.00
32_N35_Y0.7521.00
178_K183_Y0.7521.00
88_K161_K0.7521.00
17_Y20_S0.7501.00
67_D70_K0.7441.00
11_A114_I0.7441.00
178_K187_K0.7411.00
60_R143_A0.7391.00
145_L148_N0.7361.00
200_A206_S0.7341.00
229_I233_A0.7331.00
8_G28_I0.7321.00
251_G255_E0.7301.00
50_P53_W0.7281.00
198_R204_I0.7281.00
130_T138_E0.7271.00
63_S71_I0.7261.00
115_D127_V0.7261.00
131_R136_T0.7211.00
197_I203_S0.7111.00
182_N188_R0.7101.00
101_V106_N0.7091.00
101_V113_V0.7061.00
246_E249_L0.7021.00
231_P267_Q0.7021.00
174_Y177_S0.7001.00
59_I65_Y0.6991.00
190_K196_D0.6981.00
84_I89_W0.6981.00
196_D199_G0.6971.00
191_N195_K0.6961.00
60_R65_Y0.6951.00
134_I138_E0.6931.00
68_G71_I0.6901.00
227_E231_P0.6871.00
128_Y135_E0.6861.00
197_I202_I0.6801.00
42_I83_V0.6781.00
202_I206_S0.6761.00
2_R110_F0.6751.00
189_F192_F0.6721.00
112_Y243_I0.6711.00
130_T137_E0.6701.00
264_I268_K0.6701.00
231_P264_I0.6691.00
196_D200_A0.6681.00
63_S144_I0.6671.00
54_K57_F0.6621.00
44_P230_R0.6611.00
207_V253_L0.6611.00
62_F66_I0.6581.00
224_L275_R0.6561.00
65_Y146_E0.6541.00
68_G72_Y0.6541.00
251_G254_N0.6521.00
131_R138_E0.6521.00
112_Y249_L0.6521.00
205_G220_L0.6461.00
113_V211_K0.6441.00
269_M273_L0.6441.00
15_L240_F0.6441.00
225_S274_Y0.6431.00
66_I69_E0.6421.00
123_D126_V0.6391.00
18_L50_P0.6321.00
63_S70_K0.6301.00
208_K211_K0.6291.00
135_E140_D0.6281.00
135_E139_F0.6251.00
13_S28_I0.6241.00
214_I236_A0.6231.00
189_F195_K0.6221.00
52_N79_T0.6211.00
212_L253_L0.6201.00
132_A139_F0.6201.00
144_I147_F0.6201.00
178_K186_R0.6201.00
241_E245_K0.6191.00
74_V77_R0.6191.00
158_F168_G0.6131.00
165_Y169_A0.6131.00
144_I148_N0.6111.00
24_Y243_I0.6091.00
128_Y136_T0.6091.00
266_I269_M0.6071.00
180_L187_K0.6061.00
124_R213_R0.6051.00
142_E146_E0.6051.00
221_V271_L0.6041.00
156_W160_S0.6031.00
69_E73_D0.6021.00
182_N187_K0.6011.00
193_E196_D0.5991.00
46_I263_R0.5971.00
115_D122_M0.5971.00
132_A137_E0.5951.00
219_G260_I0.5951.00
133_I138_E0.5901.00
234_I238_Y0.5891.00
180_L188_R0.5891.00
39_C86_K0.5891.00
135_E164_E0.5891.00
160_S164_E0.5831.00
51_F89_W0.5821.00
254_N257_L0.5801.00
50_P234_I0.5801.00
208_K250_D0.5801.00
62_F65_Y0.5791.00
195_K198_R0.5781.00
131_R137_E0.5781.00
161_K164_E0.5771.00
141_D144_I0.5771.00
113_V210_K0.5751.00
87_W91_N0.5751.00
65_Y71_I0.5711.00
18_L236_A0.5701.00
234_I260_I0.5701.00
258_S262_K0.5691.00
6_L31_I0.5681.00
133_I140_D0.5681.00
178_K184_Y0.5661.00
219_G264_I0.5661.00
167_I172_L0.5651.00
196_D205_G0.5641.00
130_T139_F0.5621.00
134_I140_D0.5591.00
227_E230_R0.5591.00
201_P206_S0.5581.00
49_P53_W0.5581.00
128_Y137_E0.5541.00
43_V47_Y0.5541.00
179_E186_R0.5521.00
68_G73_D0.5511.00
67_D73_D0.5501.00
45_N49_P0.5481.00
166_N169_A0.5471.00
190_K195_K0.5461.00
164_E167_I0.5451.00
58_G62_F0.5451.00
4_A99_V0.5431.00
210_K246_E0.5421.00
227_E267_Q0.5411.00
133_I137_E0.5411.00
31_I120_Y0.5401.00
238_Y256_K0.5391.00
171_F175_K0.5381.00
115_D217_A0.5351.00
270_L273_L0.5341.00
128_Y134_I0.5321.00
101_V110_F0.5311.00
52_N78_H0.5301.00
111_D210_K0.5291.00
199_G205_G0.5291.00
67_D72_Y0.5291.00
22_I241_E0.5271.00
25_E111_D0.5271.00
135_E193_E0.5261.00
190_K194_V0.5221.00
197_I204_I0.5211.00
101_V108_K0.5201.00
115_D126_V0.5171.00
192_F196_D0.5171.00
66_I71_I0.5171.00
132_A140_D0.5171.00
88_K92_D0.5151.00
112_Y250_D0.5141.00
58_G80_K0.5131.00
12_G116_S0.5111.00
274_Y277_S0.5091.00
222_F225_S0.5061.00
182_N190_K0.5061.00
212_L257_L0.5051.00
259_I263_R0.5031.00
11_A236_A0.5021.00
199_G206_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pn0A 3 1 100 0.424 Contact Map
2dkhA 2 0.9637 100 0.442 Contact Map
3aljA 1 0.9245 100 0.442 Contact Map
2qa1A 2 0.9637 100 0.444 Contact Map
3rp8A 1 0.9426 100 0.446 Contact Map
4bjzA 2 0.9456 100 0.446 Contact Map
2qa2A 2 0.9668 100 0.447 Contact Map
2x3nA 1 0.8671 100 0.448 Contact Map
4k22A 4 0.8429 100 0.448 Contact Map
4j33A 1 0.8701 100 0.45 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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