GREMLIN Database
OGG1 - Probable N-glycosylase/DNA lyase
UniProt: Q97ZK2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 207 (180)
Sequences: 174 (151)
Seq/√Len: 11.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_L92_A3.4650.98
179_L190_V3.3340.97
142_L151_D2.9720.95
44_A55_L2.8000.92
183_A193_L2.7190.91
43_T132_H2.6970.91
37_L133_F2.5500.88
129_E132_H2.5470.88
119_L130_A2.3580.84
111_D114_L2.3190.83
140_F191_G2.2930.82
52_Y79_Y2.2890.82
34_F93_R2.2400.81
133_F137_V2.1170.76
62_I70_I2.1040.76
43_T129_E2.0870.75
45_N55_L2.0180.73
40_C80_R2.0040.72
44_A129_E1.9860.72
160_G187_N1.9120.69
15_V52_Y1.8890.68
134_L138_G1.8850.67
186_L192_I1.8810.67
98_G177_N1.8490.66
48_F149_I1.8420.66
46_S147_R1.8390.65
127_M173_I1.8380.65
58_L65_A1.8300.65
58_L85_K1.8270.65
40_C146_D1.8260.65
67_E71_R1.7980.64
72_N186_L1.7810.63
91_M123_K1.7570.62
183_A188_M1.6900.59
152_F197_I1.6790.58
122_I170_S1.6220.55
103_E187_N1.6190.55
132_H195_L1.6180.55
63_Y150_I1.6140.55
80_R146_D1.5610.52
14_R17_E1.5470.52
72_N184_S1.5270.51
44_A132_H1.5020.50
72_N181_S1.4610.48
41_L99_R1.4610.48
177_N181_S1.4540.47
41_L119_L1.4360.46
87_K91_M1.4230.46
44_A190_V1.3830.44
41_L157_G1.3710.43
140_F189_S1.3680.43
142_L183_A1.3630.43
87_K117_E1.3580.43
43_T46_S1.3380.42
82_Y140_F1.3360.42
175_F198_W1.3230.41
55_L129_E1.3120.40
39_L48_F1.2980.40
37_L137_V1.2970.40
33_W139_Y1.2740.39
38_T89_I1.2480.37
51_A85_K1.2240.36
46_S201_E1.2050.36
134_L168_S1.2020.35
151_D201_E1.1990.35
118_R121_N1.1980.35
43_T78_K1.1740.34
51_A55_L1.1670.34
79_Y140_F1.1620.34
37_L138_G1.1530.33
58_L91_M1.1510.33
145_I179_L1.1330.32
36_E136_N1.1330.32
44_A152_F1.1300.32
61_K85_K1.1060.31
39_L47_S1.1050.31
79_Y192_I1.1020.31
38_T62_I1.1020.31
57_C66_N1.0910.31
29_N121_N1.0910.31
74_L198_W1.0900.31
182_I191_G1.0890.31
45_N129_E1.0810.30
153_M175_F1.0780.30
48_F144_I1.0700.30
66_N111_D1.0620.29
178_I182_I1.0510.29
34_F89_I1.0420.29
24_L75_K1.0160.28
145_I178_I0.9970.27
45_N132_H0.9800.26
186_L197_I0.9760.26
110_E114_L0.9760.26
95_K177_N0.9740.26
158_A168_S0.9610.25
46_S79_Y0.9580.25
54_A145_I0.9510.25
20_D32_V0.9510.25
120_L127_M0.9420.25
113_Q117_E0.9310.24
45_N152_F0.9300.24
30_E98_G0.9240.24
25_N28_S0.9230.24
81_F146_D0.9220.24
47_S82_Y0.9140.24
42_L54_A0.9110.24
48_F132_H0.9040.23
88_Y123_K0.8980.23
72_N114_L0.8920.23
155_R201_E0.8850.23
44_A196_F0.8850.23
45_N182_I0.8840.23
45_N79_Y0.8840.23
48_F51_A0.8830.23
94_E170_S0.8780.23
87_K114_L0.8770.23
120_L145_I0.8650.22
137_V140_F0.8630.22
65_A85_K0.8610.22
120_L133_F0.8580.22
33_W57_C0.8560.22
18_R43_T0.8510.22
55_L85_K0.8450.21
98_G127_M0.8420.21
54_A200_K0.8420.21
73_I175_F0.8270.21
145_I198_W0.8210.21
65_A178_I0.8180.21
82_Y85_K0.8110.20
121_N197_I0.8090.20
18_R21_E0.8080.20
19_V54_A0.8060.20
129_E195_L0.8000.20
25_N109_D0.7940.20
45_N196_F0.7940.20
61_K72_N0.7930.20
141_D197_I0.7920.20
47_S65_A0.7790.19
80_R198_W0.7760.19
85_K120_L0.7740.19
19_V197_I0.7740.19
57_C122_I0.7720.19
55_L190_V0.7700.19
75_K87_K0.7700.19
147_R167_L0.7700.19
24_L82_Y0.7610.19
20_D72_N0.7610.19
54_A74_L0.7520.19
168_S190_V0.7520.19
40_C129_E0.7500.18
80_R148_H0.7480.18
33_W145_I0.7450.18
43_T48_F0.7420.18
152_F201_E0.7400.18
134_L190_V0.7400.18
36_E119_L0.7330.18
111_D161_E0.7250.18
97_Y131_S0.7250.18
68_E71_R0.7110.17
71_R83_N0.7080.17
50_S77_C0.6980.17
94_E181_S0.6930.17
67_E181_S0.6890.17
69_E99_R0.6880.17
175_F179_L0.6880.17
28_S32_V0.6820.17
44_A79_Y0.6820.17
127_M149_I0.6800.17
136_N194_D0.6790.16
156_I186_L0.6740.16
64_Y181_S0.6740.16
43_T195_L0.6720.16
91_M100_L0.6710.16
46_S132_H0.6670.16
88_Y125_I0.6670.16
72_N91_M0.6650.16
68_E110_E0.6630.16
134_L153_M0.6630.16
40_C194_D0.6610.16
86_A167_L0.6580.16
39_L190_V0.6550.16
60_Q174_S0.6540.16
36_E194_D0.6520.16
96_V191_G0.6520.16
26_N68_E0.6520.16
133_F180_K0.6510.16
81_F193_L0.6500.16
24_L28_S0.6490.16
59_G62_I0.6490.16
145_I161_E0.6400.15
101_K169_K0.6320.15
147_R155_R0.6290.15
19_V188_M0.6270.15
45_N147_R0.6270.15
22_F132_H0.6240.15
153_M179_L0.6210.15
159_I171_L0.6210.15
66_N177_N0.6200.15
80_R194_D0.6150.15
66_N69_E0.6140.15
196_F201_E0.6120.15
133_F153_M0.6110.15
40_C148_H0.6110.15
160_G197_I0.6100.15
48_F88_Y0.6100.15
35_R79_Y0.6080.15
189_S192_I0.6060.15
75_K89_I0.6030.15
124_G128_K0.6000.14
124_G135_R0.6000.14
135_R172_Y0.6000.14
135_R176_E0.6000.14
124_G176_E0.6000.14
128_K176_E0.6000.14
128_K172_Y0.6000.14
128_K135_R0.6000.14
124_G172_Y0.6000.14
116_R176_E0.6000.14
116_R135_R0.6000.14
116_R172_Y0.6000.14
172_Y176_E0.6000.14
116_R124_G0.6000.14
116_R128_K0.6000.14
16_L25_N0.5990.14
178_I187_N0.5960.14
115_A137_V0.5940.14
166_Q175_F0.5920.14
129_E134_L0.5880.14
48_F199_Y0.5850.14
64_Y78_K0.5810.14
111_D170_S0.5800.14
117_E174_S0.5770.14
126_G193_L0.5740.14
170_S184_S0.5720.14
171_L174_S0.5700.14
151_D167_L0.5660.14
71_R75_K0.5630.14
154_R178_I0.5620.14
23_R101_K0.5610.14
79_Y190_V0.5610.14
16_L109_D0.5590.14
14_R20_D0.5560.13
129_E133_F0.5510.13
23_R140_F0.5490.13
88_Y198_W0.5490.13
50_S70_I0.5470.13
28_S193_L0.5470.13
48_F129_E0.5460.13
78_K86_A0.5450.13
151_D189_S0.5440.13
99_R157_G0.5440.13
47_S55_L0.5420.13
42_L79_Y0.5410.13
67_E114_L0.5380.13
126_G183_A0.5350.13
34_F132_H0.5340.13
137_V173_I0.5290.13
86_A91_M0.5280.13
63_Y142_L0.5280.13
60_Q64_Y0.5150.13
16_L19_V0.5130.13
79_Y85_K0.5120.12
39_L52_Y0.5090.12
58_L196_F0.5080.12
177_N180_K0.5070.12
194_D198_W0.5030.12
110_E118_R0.5030.12
41_L185_N0.5010.12
154_R181_S0.5010.12
62_I200_K0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fhgA 2 1 100 0.546 Contact Map
3fhfA 1 0.971 100 0.569 Contact Map
3n0uA 1 0.971 100 0.592 Contact Map
4b21A 2 0.9034 99.8 0.748 Contact Map
4unfA 1 0.9372 99.6 0.773 Contact Map
2xhiA 1 0.9324 99.6 0.773 Contact Map
3s6iA 1 0.9082 99.6 0.773 Contact Map
1pu6A 1 0.8841 99.6 0.776 Contact Map
2yg9A 1 0.8744 99.6 0.777 Contact Map
2h56A 1 0.9179 99.6 0.78 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0079 seconds.