Q97ZK1 - SULSO - GREMLIN Contacts

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Q97ZK1 - D-3-phosphoglycerate dehydrogenase (SerA-1)

UniProt:	Q97ZK1	Sequences: MISMETIQGVNSIGKLDFKVLITDPVDQYMIRTLQNNGLIVDYKPEITREELLKIIDQYQVLIVRSRTKVDKEIIRYGVNLKIIARAGIGLDNIDTEEASKRNIKIVYAPGASTDSAAELTIGLLIAAARKLYDSMNMAKGGIFKKIEGIELAGKTIGIVGFGRIGTKVAKVCKALDMNVIAYDVINIKEKANIVGVRVAESLEELLKNSDVITFHVTVGKDAKPILNKDTFNYIKDNAIIINTSRAVVIDGKALLEYIDKKHLTYATDVLWNEPPKEDWEIKLLRHERVIVTTHIGAQTKEAQHRVAVVTTDNLITALKEIGVLK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	326 (281)
Sequences:	19241 (13257)
Seq/√Len:	790.9

ECOLI - SERA GHRB LDHD GHRA PDXB
BACSU - SERA TKRA YOAD
HALSA - Q9HMR0 Q9HSS1 Q9HPW9
SULSO - Q97ZK1 Q97U35

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
228_N	231_T	4.218	1.00
229_K	257_E	3.191	1.00
251_D	254_A	2.962	1.00
157_I	173_C	2.656	1.00
260_D	287_H	2.552	1.00
156_T	179_N	2.487	1.00
219_V	248_V	2.476	1.00
60_Q	82_K	2.395	1.00
204_E	234_Y	2.366	1.00
156_T	181_I	2.198	1.00
181_I	209_N	2.172	1.00
207_L	231_T	2.153	1.00
158_G	206_L	2.145	1.00
237_D	263_H	2.122	1.00
162_F	182_A	2.096	1.00
225_P	272_W	2.074	1.00
208_K	234_Y	2.067	1.00
136_M	140_K	2.042	1.00
317_T	322_I	2.002	1.00
202_S	205_E	1.968	1.00
122_I	173_C	1.964	1.00
233_N	263_H	1.964	1.00
72_K	101_K	1.949	1.00
129_A	212_V	1.914	1.00
131_K	134_D	1.911	1.00
168_K	171_K	1.874	1.00
257_E	261_K	1.872	1.00
83_I	107_V	1.852	1.00
225_P	251_D	1.824	1.00
123_G	132_L	1.823	1.00
158_G	210_S	1.794	1.00
204_E	231_T	1.772	1.00
72_K	76_R	1.767	1.00
58_Q	80_N	1.761	1.00
125_L	212_V	1.758	1.00
260_D	283_K	1.733	1.00
179_N	198_R	1.732	1.00
232_F	258_Y	1.729	1.00
239_A	264_L	1.729	1.00
240_I	266_Y	1.689	1.00
227_L	232_F	1.685	1.00
229_K	233_N	1.676	1.00
122_I	176_L	1.672	1.00
98_E	101_K	1.660	1.00
205_E	209_N	1.638	1.00
115_D	153_A	1.635	1.00
256_L	287_H	1.627	1.00
127_A	133_Y	1.623	1.00
241_I	250_I	1.619	1.00
287_H	290_V	1.611	1.00
252_G	272_W	1.602	1.00
256_L	260_D	1.557	1.00
316_I	320_K	1.552	1.00
159_I	166_G	1.548	1.00
219_V	224_K	1.547	1.00
76_R	102_R	1.536	1.00
227_L	231_T	1.526	1.00
48_T	51_E	1.520	1.00
157_I	178_M	1.513	1.00
235_I	239_A	1.511	1.00
49_R	73_E	1.503	1.00
150_I	155_K	1.503	1.00
221_K	224_K	1.495	1.00
120_L	297_G	1.490	1.00
230_D	234_Y	1.472	1.00
128_A	266_Y	1.470	1.00
155_K	302_E	1.468	1.00
181_I	200_A	1.445	1.00
121_T	169_V	1.436	1.00
211_D	236_K	1.435	1.00
231_T	234_Y	1.424	1.00
207_L	227_L	1.422	1.00
224_K	248_V	1.411	1.00
173_C	178_M	1.402	1.00
49_R	71_D	1.401	1.00
168_K	172_V	1.398	1.00
60_Q	80_N	1.395	1.00
137_N	140_K	1.389	1.00
115_D	168_K	1.387	1.00
42_D	59_Y	1.382	1.00
240_I	265_T	1.380	1.00
229_K	254_A	1.380	1.00
169_V	216_H	1.376	1.00
119_E	172_V	1.373	1.00
215_F	249_V	1.366	1.00
151_E	306_R	1.354	1.00
71_D	74_I	1.334	1.00
245_S	249_V	1.332	1.00
179_N	209_N	1.327	1.00
137_N	141_G	1.324	1.00
61_V	83_I	1.320	1.00
99_A	106_I	1.312	1.00
128_A	240_I	1.308	1.00
37_N	316_I	1.306	1.00
120_L	124_L	1.305	1.00
53_L	77_Y	1.300	1.00
72_K	98_E	1.289	1.00
121_T	244_T	1.283	1.00
216_H	244_T	1.278	1.00
255_L	267_A	1.272	1.00
56_I	78_G	1.271	1.00
138_M	143_I	1.267	1.00
215_F	241_I	1.248	1.00
159_I	214_T	1.238	1.00
159_I	170_A	1.234	1.00
75_I	102_R	1.224	1.00
133_Y	136_M	1.213	1.00
171_K	177_D	1.212	1.00
309_V	313_D	1.212	1.00
206_L	210_S	1.207	1.00
271_L	292_V	1.201	1.00
160_V	217_V	1.197	1.00
198_R	209_N	1.187	1.00
313_D	317_T	1.185	1.00
128_A	291_I	1.183	1.00
97_E	101_K	1.180	1.00
217_V	249_V	1.178	1.00
83_I	318_A	1.177	1.00
204_E	230_D	1.168	1.00
187_N	199_V	1.165	1.00
230_D	233_N	1.164	1.00
98_E	102_R	1.163	1.00
181_I	210_S	1.157	1.00
160_V	226_I	1.154	1.00
126_I	176_L	1.141	1.00
118_A	172_V	1.138	1.00
162_F	167_T	1.129	1.00
253_K	283_K	1.128	1.00
156_T	209_N	1.128	1.00
203_L	231_T	1.127	1.00
75_I	99_A	1.124	1.00
169_V	214_T	1.124	1.00
160_V	227_L	1.117	1.00
213_I	235_I	1.116	1.00
212_V	240_I	1.113	1.00
76_R	98_E	1.110	1.00
115_D	172_V	1.098	1.00
86_R	94_I	1.096	1.00
123_G	126_I	1.086	1.00
200_A	209_N	1.083	1.00
256_L	283_K	1.083	1.00
142_G	286_R	1.083	1.00
125_L	157_I	1.076	1.00
226_I	249_V	1.075	1.00
273_N	277_K	1.074	1.00
85_A	314_N	1.073	1.00
94_I	99_A	1.072	1.00
97_E	100_S	1.069	1.00
120_L	293_T	1.069	1.00
236_K	239_A	1.063	1.00
174_K	196_G	1.049	1.00
125_L	173_C	1.039	1.00
203_L	207_L	1.036	1.00
259_I	290_V	1.034	1.00
228_N	254_A	1.032	1.00
184_D	188_I	1.023	1.00
113_S	298_A	1.014	1.00
129_A	150_I	1.014	1.00
85_A	311_T	1.009	1.00
258_Y	263_H	1.001	1.00
185_V	222_D	0.999	1.00
96_T	100_S	0.994	1.00
238_N	263_H	0.994	1.00
214_T	244_T	0.990	1.00
160_V	213_I	0.985	1.00
51_E	54_K	0.983	1.00
171_K	174_K	0.983	1.00
129_A	155_K	0.981	1.00
260_D	286_R	0.979	1.00
49_R	53_L	0.966	1.00
305_H	309_V	0.963	1.00
95_D	98_E	0.956	1.00
232_F	241_I	0.952	1.00
124_L	291_I	0.950	1.00
160_V	203_L	0.946	1.00
61_V	315_L	0.943	1.00
169_V	173_C	0.942	1.00
167_T	188_I	0.941	1.00
314_N	317_T	0.933	1.00
182_A	197_V	0.928	1.00
122_I	172_V	0.927	1.00
200_A	205_E	0.922	1.00
54_K	57_D	0.920	1.00
217_V	226_I	0.917	1.00
200_A	206_L	0.916	1.00
86_R	93_N	0.914	1.00
252_G	273_N	0.912	1.00
258_Y	264_L	0.910	1.00
210_S	213_I	0.910	1.00
94_I	106_I	0.909	1.00
153_A	177_D	0.908	1.00
228_N	251_D	0.907	1.00
85_A	107_V	0.902	1.00
157_I	214_T	0.901	1.00
167_T	191_K	0.873	1.00
160_V	215_F	0.871	1.00
250_I	255_L	0.868	1.00
57_D	77_Y	0.866	1.00
116_S	151_E	0.866	1.00
182_A	199_V	0.862	1.00
137_N	288_E	0.861	1.00
227_L	241_I	0.860	1.00
215_F	227_L	0.859	1.00
204_E	208_K	0.858	1.00
170_A	180_V	0.856	1.00
127_A	132_L	0.854	1.00
133_Y	137_N	0.851	1.00
61_V	319_L	0.850	1.00
159_I	169_V	0.846	1.00
273_N	276_P	0.843	1.00
129_A	240_I	0.841	1.00
122_I	169_V	0.840	1.00
218_T	223_A	0.839	1.00
39_L	42_D	0.830	1.00
114_T	168_K	0.830	1.00
162_F	170_A	0.830	1.00
188_I	191_K	0.829	1.00
151_E	300_T	0.828	1.00
51_E	55_I	0.828	1.00
150_I	301_K	0.826	1.00
232_F	235_I	0.815	1.00
238_N	265_T	0.811	1.00
255_L	264_L	0.808	1.00
127_A	291_I	0.807	1.00
232_F	263_H	0.805	1.00
83_I	315_L	0.801	1.00
53_L	74_I	0.799	1.00
268_T	290_V	0.799	1.00
84_I	99_A	0.797	1.00
152_L	178_M	0.792	1.00
252_G	284_L	0.788	1.00
306_R	309_V	0.788	1.00
88_G	93_N	0.788	1.00
115_D	119_E	0.786	1.00
117_A	297_G	0.782	1.00
109_A	310_V	0.780	1.00
150_I	302_E	0.780	1.00
75_I	84_I	0.777	1.00
229_K	263_H	0.776	1.00
207_L	213_I	0.775	1.00
114_T	164_R	0.775	1.00
129_A	133_Y	0.774	1.00
257_E	260_D	0.773	1.00
266_Y	291_I	0.772	1.00
91_L	96_T	0.768	1.00
123_G	127_A	0.766	1.00
253_K	257_E	0.764	1.00
73_E	76_R	0.763	1.00
135_S	296_I	0.758	1.00
205_E	208_K	0.757	1.00
121_T	216_H	0.757	1.00
233_N	261_K	0.756	1.00
207_L	234_Y	0.756	1.00
203_L	226_I	0.755	1.00
115_D	151_E	0.753	1.00
37_N	320_K	0.749	1.00
72_K	95_D	0.740	1.00
86_R	91_L	0.740	1.00
72_K	102_R	0.739	1.00
121_T	214_T	0.739	1.00
62_L	70_V	0.737	1.00
53_L	73_E	0.735	1.00
219_V	223_A	0.735	1.00
253_K	272_W	0.733	1.00
116_S	303_A	0.732	1.00
183_Y	203_L	0.731	1.00
56_I	62_L	0.728	1.00
271_L	276_P	0.728	1.00
42_D	55_I	0.726	1.00
156_T	210_S	0.714	1.00
213_I	239_A	0.714	1.00
259_I	289_R	0.713	1.00
125_L	169_V	0.710	1.00
122_I	125_L	0.707	1.00
118_A	168_K	0.703	1.00
257_E	263_H	0.703	1.00
111_G	164_R	0.702	1.00
172_V	176_L	0.697	1.00
153_A	306_R	0.696	1.00
207_L	235_I	0.696	1.00
125_L	152_L	0.695	1.00
63_I	311_T	0.693	1.00
255_L	268_T	0.688	1.00
155_K	212_V	0.686	1.00
181_I	198_R	0.677	1.00
279_D	283_K	0.677	1.00
150_I	238_N	0.676	1.00
156_T	211_D	0.675	1.00
301_K	305_H	0.675	1.00
276_P	285_L	0.672	1.00
125_L	242_I	0.668	1.00
111_G	310_V	0.667	1.00
136_M	139_A	0.666	1.00
184_D	187_N	0.662	1.00
121_T	124_L	0.662	1.00
215_F	245_S	0.659	1.00
85_A	315_L	0.658	1.00
124_L	127_A	0.658	1.00
220_G	223_A	0.657	1.00
119_E	130_R	0.655	1.00
313_D	316_I	0.652	1.00
57_D	79_V	0.652	1.00
162_F	199_V	0.651	1.00
138_M	141_G	0.651	1.00
73_E	77_Y	0.650	1.00
229_K	261_K	0.649	1.00
213_I	236_K	0.647	1.00
50_E	54_K	0.645	1.00
250_I	267_A	0.641	1.00
156_T	236_K	0.641	1.00
138_M	145_K	0.639	1.00
167_T	171_K	0.636	1.00
109_A	307_V	0.635	1.00
224_K	272_W	0.634	1.00
267_A	290_V	0.634	1.00
252_G	256_L	0.633	1.00
190_E	194_I	0.630	1.00
178_M	212_V	0.629	1.00
285_L	292_V	0.626	1.00
217_V	245_S	0.624	1.00
82_K	318_A	0.624	1.00
312_T	316_I	0.621	1.00
157_I	169_V	0.619	1.00
174_K	195_V	0.618	1.00
79_V	102_R	0.618	1.00
238_N	264_L	0.615	1.00
115_D	177_D	0.614	1.00
181_I	206_L	0.614	1.00
92_D	219_V	0.611	1.00
139_A	285_L	0.611	1.00
91_L	108_Y	0.611	1.00
111_G	114_T	0.611	1.00
135_S	294_T	0.610	1.00
125_L	214_T	0.610	1.00
279_D	285_L	0.609	1.00
116_S	119_E	0.605	1.00
107_V	314_N	0.603	1.00
85_A	109_A	0.602	1.00
58_Q	79_V	0.602	1.00
258_Y	261_K	0.601	1.00
61_V	85_A	0.595	1.00
248_V	272_W	0.595	1.00
70_V	75_I	0.594	1.00
158_G	183_Y	0.594	1.00
194_I	197_V	0.594	1.00
191_K	194_I	0.591	1.00
64_V	70_V	0.587	1.00
299_Q	304_Q	0.585	1.00
136_M	292_V	0.585	1.00
172_V	175_A	0.583	1.00
229_K	258_Y	0.582	1.00
120_L	130_R	0.580	1.00
116_S	300_T	0.579	1.00
138_M	147_I	0.577	1.00
174_K	180_V	0.577	1.00
310_V	314_N	0.575	1.00
152_L	176_L	0.575	1.00
150_I	265_T	0.574	1.00
127_A	136_M	0.572	1.00
120_L	123_G	0.568	1.00
112_A	307_V	0.565	1.00
260_D	288_E	0.564	1.00
283_K	287_H	0.564	1.00
102_R	105_K	0.563	1.00
256_L	290_V	0.562	1.00
155_K	178_M	0.562	1.00
170_A	182_A	0.560	1.00
39_L	316_I	0.560	1.00
225_P	228_N	0.560	1.00
112_A	310_V	0.559	1.00
225_P	248_V	0.558	1.00
134_D	138_M	0.555	1.00
129_A	152_L	0.555	1.00
217_V	223_A	0.553	1.00
162_F	197_V	0.553	1.00
195_V	198_R	0.549	1.00
160_V	206_L	0.542	1.00
143_I	146_K	0.542	1.00
75_I	104_I	0.540	1.00
44_K	47_I	0.540	1.00
207_L	226_I	0.538	1.00
92_D	248_V	0.537	1.00
135_S	147_I	0.537	1.00
139_A	271_L	0.535	1.00
50_E	73_E	0.534	1.00
124_L	128_A	0.534	1.00
55_I	58_Q	0.532	1.00
246_R	295_H	0.532	1.00
129_A	178_M	0.531	1.00
44_K	55_I	0.529	1.00
134_D	147_I	0.528	1.00
316_I	322_I	0.528	1.00
155_K	211_D	0.528	1.00
189_K	199_V	0.527	1.00
133_Y	291_I	0.526	1.00
188_I	199_V	0.525	1.00
302_E	305_H	0.522	1.00
213_I	227_L	0.522	1.00
278_E	283_K	0.520	1.00
171_K	175_A	0.519	1.00
262_K	289_R	0.519	1.00
162_F	184_D	0.519	1.00
83_I	105_K	0.519	1.00
112_A	303_A	0.519	1.00
311_T	314_N	0.518	1.00
133_Y	140_K	0.517	1.00
87_A	307_V	0.514	1.00
78_G	81_L	0.512	1.00
195_V	199_V	0.511	1.00
223_A	249_V	0.509	1.00
131_K	147_I	0.508	1.00
185_V	188_I	0.507	1.00
117_A	121_T	0.507	1.00
199_V	202_S	0.507	1.00
253_K	256_L	0.507	1.00
139_A	292_V	0.506	1.00
110_P	164_R	0.505	1.00
279_D	286_R	0.504	1.00
317_T	321_E	0.504	1.00
198_R	205_E	0.501	1.00
309_V	312_T	0.501	1.00
113_S	116_S	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2g76A	2	0.9172	100	0.227	Contact Map
1ygyA	4	0.9387	100	0.237	Contact Map
3ba1A	2	0.9325	100	0.238	Contact Map
1wwkA	2	0.9233	100	0.241	Contact Map
1sc6A	4	0.9141	100	0.241	Contact Map
4g2nA	3	0.9387	100	0.245	Contact Map
3k5pA	3	0.9356	100	0.246	Contact Map
2d0iA	2	0.9356	100	0.246	Contact Map
2w2kA	2	0.9417	100	0.256	Contact Map
2eklA	2	0.9448	100	0.256	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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