GREMLIN Database
Q97ZK1 - D-3-phosphoglycerate dehydrogenase (SerA-1)
UniProt: Q97ZK1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 326 (281)
Sequences: 19241 (13257)
Seq/√Len: 790.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
228_N231_T4.2181.00
229_K257_E3.1911.00
251_D254_A2.9621.00
157_I173_C2.6561.00
260_D287_H2.5521.00
156_T179_N2.4871.00
219_V248_V2.4761.00
60_Q82_K2.3951.00
204_E234_Y2.3661.00
156_T181_I2.1981.00
181_I209_N2.1721.00
207_L231_T2.1531.00
158_G206_L2.1451.00
237_D263_H2.1221.00
162_F182_A2.0961.00
225_P272_W2.0741.00
208_K234_Y2.0671.00
136_M140_K2.0421.00
317_T322_I2.0021.00
202_S205_E1.9681.00
122_I173_C1.9641.00
233_N263_H1.9641.00
72_K101_K1.9491.00
129_A212_V1.9141.00
131_K134_D1.9111.00
168_K171_K1.8741.00
257_E261_K1.8721.00
83_I107_V1.8521.00
225_P251_D1.8241.00
123_G132_L1.8231.00
158_G210_S1.7941.00
204_E231_T1.7721.00
72_K76_R1.7671.00
58_Q80_N1.7611.00
125_L212_V1.7581.00
260_D283_K1.7331.00
179_N198_R1.7321.00
232_F258_Y1.7291.00
239_A264_L1.7291.00
240_I266_Y1.6891.00
227_L232_F1.6851.00
229_K233_N1.6761.00
122_I176_L1.6721.00
98_E101_K1.6601.00
205_E209_N1.6381.00
115_D153_A1.6351.00
256_L287_H1.6271.00
127_A133_Y1.6231.00
241_I250_I1.6191.00
287_H290_V1.6111.00
252_G272_W1.6021.00
256_L260_D1.5571.00
316_I320_K1.5521.00
159_I166_G1.5481.00
219_V224_K1.5471.00
76_R102_R1.5361.00
227_L231_T1.5261.00
48_T51_E1.5201.00
157_I178_M1.5131.00
235_I239_A1.5111.00
49_R73_E1.5031.00
150_I155_K1.5031.00
221_K224_K1.4951.00
120_L297_G1.4901.00
230_D234_Y1.4721.00
128_A266_Y1.4701.00
155_K302_E1.4681.00
181_I200_A1.4451.00
121_T169_V1.4361.00
211_D236_K1.4351.00
231_T234_Y1.4241.00
207_L227_L1.4221.00
224_K248_V1.4111.00
173_C178_M1.4021.00
49_R71_D1.4011.00
168_K172_V1.3981.00
60_Q80_N1.3951.00
137_N140_K1.3891.00
115_D168_K1.3871.00
42_D59_Y1.3821.00
240_I265_T1.3801.00
229_K254_A1.3801.00
169_V216_H1.3761.00
119_E172_V1.3731.00
215_F249_V1.3661.00
151_E306_R1.3541.00
71_D74_I1.3341.00
245_S249_V1.3321.00
179_N209_N1.3271.00
137_N141_G1.3241.00
61_V83_I1.3201.00
99_A106_I1.3121.00
128_A240_I1.3081.00
37_N316_I1.3061.00
120_L124_L1.3051.00
53_L77_Y1.3001.00
72_K98_E1.2891.00
121_T244_T1.2831.00
216_H244_T1.2781.00
255_L267_A1.2721.00
56_I78_G1.2711.00
138_M143_I1.2671.00
215_F241_I1.2481.00
159_I214_T1.2381.00
159_I170_A1.2341.00
75_I102_R1.2241.00
133_Y136_M1.2131.00
171_K177_D1.2121.00
309_V313_D1.2121.00
206_L210_S1.2071.00
271_L292_V1.2011.00
160_V217_V1.1971.00
198_R209_N1.1871.00
313_D317_T1.1851.00
128_A291_I1.1831.00
97_E101_K1.1801.00
217_V249_V1.1781.00
83_I318_A1.1771.00
204_E230_D1.1681.00
187_N199_V1.1651.00
230_D233_N1.1641.00
98_E102_R1.1631.00
181_I210_S1.1571.00
160_V226_I1.1541.00
126_I176_L1.1411.00
118_A172_V1.1381.00
162_F167_T1.1291.00
253_K283_K1.1281.00
156_T209_N1.1281.00
203_L231_T1.1271.00
75_I99_A1.1241.00
169_V214_T1.1241.00
160_V227_L1.1171.00
213_I235_I1.1161.00
212_V240_I1.1131.00
76_R98_E1.1101.00
115_D172_V1.0981.00
86_R94_I1.0961.00
123_G126_I1.0861.00
200_A209_N1.0831.00
256_L283_K1.0831.00
142_G286_R1.0831.00
125_L157_I1.0761.00
226_I249_V1.0751.00
273_N277_K1.0741.00
85_A314_N1.0731.00
94_I99_A1.0721.00
97_E100_S1.0691.00
120_L293_T1.0691.00
236_K239_A1.0631.00
174_K196_G1.0491.00
125_L173_C1.0391.00
203_L207_L1.0361.00
259_I290_V1.0341.00
228_N254_A1.0321.00
184_D188_I1.0231.00
113_S298_A1.0141.00
129_A150_I1.0141.00
85_A311_T1.0091.00
258_Y263_H1.0011.00
185_V222_D0.9991.00
96_T100_S0.9941.00
238_N263_H0.9941.00
214_T244_T0.9901.00
160_V213_I0.9851.00
51_E54_K0.9831.00
171_K174_K0.9831.00
129_A155_K0.9811.00
260_D286_R0.9791.00
49_R53_L0.9661.00
305_H309_V0.9631.00
95_D98_E0.9561.00
232_F241_I0.9521.00
124_L291_I0.9501.00
160_V203_L0.9461.00
61_V315_L0.9431.00
169_V173_C0.9421.00
167_T188_I0.9411.00
314_N317_T0.9331.00
182_A197_V0.9281.00
122_I172_V0.9271.00
200_A205_E0.9221.00
54_K57_D0.9201.00
217_V226_I0.9171.00
200_A206_L0.9161.00
86_R93_N0.9141.00
252_G273_N0.9121.00
258_Y264_L0.9101.00
210_S213_I0.9101.00
94_I106_I0.9091.00
153_A177_D0.9081.00
228_N251_D0.9071.00
85_A107_V0.9021.00
157_I214_T0.9011.00
167_T191_K0.8731.00
160_V215_F0.8711.00
250_I255_L0.8681.00
57_D77_Y0.8661.00
116_S151_E0.8661.00
182_A199_V0.8621.00
137_N288_E0.8611.00
227_L241_I0.8601.00
215_F227_L0.8591.00
204_E208_K0.8581.00
170_A180_V0.8561.00
127_A132_L0.8541.00
133_Y137_N0.8511.00
61_V319_L0.8501.00
159_I169_V0.8461.00
273_N276_P0.8431.00
129_A240_I0.8411.00
122_I169_V0.8401.00
218_T223_A0.8391.00
39_L42_D0.8301.00
114_T168_K0.8301.00
162_F170_A0.8301.00
188_I191_K0.8291.00
151_E300_T0.8281.00
51_E55_I0.8281.00
150_I301_K0.8261.00
232_F235_I0.8151.00
238_N265_T0.8111.00
255_L264_L0.8081.00
127_A291_I0.8071.00
232_F263_H0.8051.00
83_I315_L0.8011.00
53_L74_I0.7991.00
268_T290_V0.7991.00
84_I99_A0.7971.00
152_L178_M0.7921.00
252_G284_L0.7881.00
306_R309_V0.7881.00
88_G93_N0.7881.00
115_D119_E0.7861.00
117_A297_G0.7821.00
109_A310_V0.7801.00
150_I302_E0.7801.00
75_I84_I0.7771.00
229_K263_H0.7761.00
207_L213_I0.7751.00
114_T164_R0.7751.00
129_A133_Y0.7741.00
257_E260_D0.7731.00
266_Y291_I0.7721.00
91_L96_T0.7681.00
123_G127_A0.7661.00
253_K257_E0.7641.00
73_E76_R0.7631.00
135_S296_I0.7581.00
205_E208_K0.7571.00
121_T216_H0.7571.00
233_N261_K0.7561.00
207_L234_Y0.7561.00
203_L226_I0.7551.00
115_D151_E0.7531.00
37_N320_K0.7491.00
72_K95_D0.7401.00
86_R91_L0.7401.00
72_K102_R0.7391.00
121_T214_T0.7391.00
62_L70_V0.7371.00
53_L73_E0.7351.00
219_V223_A0.7351.00
253_K272_W0.7331.00
116_S303_A0.7321.00
183_Y203_L0.7311.00
56_I62_L0.7281.00
271_L276_P0.7281.00
42_D55_I0.7261.00
156_T210_S0.7141.00
213_I239_A0.7141.00
259_I289_R0.7131.00
125_L169_V0.7101.00
122_I125_L0.7071.00
118_A168_K0.7031.00
257_E263_H0.7031.00
111_G164_R0.7021.00
172_V176_L0.6971.00
153_A306_R0.6961.00
207_L235_I0.6961.00
125_L152_L0.6951.00
63_I311_T0.6931.00
255_L268_T0.6881.00
155_K212_V0.6861.00
181_I198_R0.6771.00
279_D283_K0.6771.00
150_I238_N0.6761.00
156_T211_D0.6751.00
301_K305_H0.6751.00
276_P285_L0.6721.00
125_L242_I0.6681.00
111_G310_V0.6671.00
136_M139_A0.6661.00
184_D187_N0.6621.00
121_T124_L0.6621.00
215_F245_S0.6591.00
85_A315_L0.6581.00
124_L127_A0.6581.00
220_G223_A0.6571.00
119_E130_R0.6551.00
313_D316_I0.6521.00
57_D79_V0.6521.00
162_F199_V0.6511.00
138_M141_G0.6511.00
73_E77_Y0.6501.00
229_K261_K0.6491.00
213_I236_K0.6471.00
50_E54_K0.6451.00
250_I267_A0.6411.00
156_T236_K0.6411.00
138_M145_K0.6391.00
167_T171_K0.6361.00
109_A307_V0.6351.00
224_K272_W0.6341.00
267_A290_V0.6341.00
252_G256_L0.6331.00
190_E194_I0.6301.00
178_M212_V0.6291.00
285_L292_V0.6261.00
217_V245_S0.6241.00
82_K318_A0.6241.00
312_T316_I0.6211.00
157_I169_V0.6191.00
174_K195_V0.6181.00
79_V102_R0.6181.00
238_N264_L0.6151.00
115_D177_D0.6141.00
181_I206_L0.6141.00
92_D219_V0.6111.00
139_A285_L0.6111.00
91_L108_Y0.6111.00
111_G114_T0.6111.00
135_S294_T0.6101.00
125_L214_T0.6101.00
279_D285_L0.6091.00
116_S119_E0.6051.00
107_V314_N0.6031.00
85_A109_A0.6021.00
58_Q79_V0.6021.00
258_Y261_K0.6011.00
61_V85_A0.5951.00
248_V272_W0.5951.00
70_V75_I0.5941.00
158_G183_Y0.5941.00
194_I197_V0.5941.00
191_K194_I0.5911.00
64_V70_V0.5871.00
299_Q304_Q0.5851.00
136_M292_V0.5851.00
172_V175_A0.5831.00
229_K258_Y0.5821.00
120_L130_R0.5801.00
116_S300_T0.5791.00
138_M147_I0.5771.00
174_K180_V0.5771.00
310_V314_N0.5751.00
152_L176_L0.5751.00
150_I265_T0.5741.00
127_A136_M0.5721.00
120_L123_G0.5681.00
112_A307_V0.5651.00
260_D288_E0.5641.00
283_K287_H0.5641.00
102_R105_K0.5631.00
256_L290_V0.5621.00
155_K178_M0.5621.00
170_A182_A0.5601.00
39_L316_I0.5601.00
225_P228_N0.5601.00
112_A310_V0.5591.00
225_P248_V0.5581.00
134_D138_M0.5551.00
129_A152_L0.5551.00
217_V223_A0.5531.00
162_F197_V0.5531.00
195_V198_R0.5491.00
160_V206_L0.5421.00
143_I146_K0.5421.00
75_I104_I0.5401.00
44_K47_I0.5401.00
207_L226_I0.5381.00
92_D248_V0.5371.00
135_S147_I0.5371.00
139_A271_L0.5351.00
50_E73_E0.5341.00
124_L128_A0.5341.00
55_I58_Q0.5321.00
246_R295_H0.5321.00
129_A178_M0.5311.00
44_K55_I0.5291.00
134_D147_I0.5281.00
316_I322_I0.5281.00
155_K211_D0.5281.00
189_K199_V0.5271.00
133_Y291_I0.5261.00
188_I199_V0.5251.00
302_E305_H0.5221.00
213_I227_L0.5221.00
278_E283_K0.5201.00
171_K175_A0.5191.00
262_K289_R0.5191.00
162_F184_D0.5191.00
83_I105_K0.5191.00
112_A303_A0.5191.00
311_T314_N0.5181.00
133_Y140_K0.5171.00
87_A307_V0.5141.00
78_G81_L0.5121.00
195_V199_V0.5111.00
223_A249_V0.5091.00
131_K147_I0.5081.00
185_V188_I0.5071.00
117_A121_T0.5071.00
199_V202_S0.5071.00
253_K256_L0.5071.00
139_A292_V0.5061.00
110_P164_R0.5051.00
279_D286_R0.5041.00
317_T321_E0.5041.00
198_R205_E0.5011.00
309_V312_T0.5011.00
113_S116_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2g76A 2 0.9172 100 0.227 Contact Map
1ygyA 4 0.9387 100 0.237 Contact Map
3ba1A 2 0.9325 100 0.238 Contact Map
1wwkA 2 0.9233 100 0.241 Contact Map
1sc6A 4 0.9141 100 0.241 Contact Map
4g2nA 3 0.9387 100 0.245 Contact Map
3k5pA 3 0.9356 100 0.246 Contact Map
2d0iA 2 0.9356 100 0.246 Contact Map
2w2kA 2 0.9417 100 0.256 Contact Map
2eklA 2 0.9448 100 0.256 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0101 seconds.