GREMLIN Database
Q97ZJ8 - DNA topoisomerase
UniProt: Q97ZJ8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 668 (572)
Sequences: 6309 (3911)
Seq/√Len: 163.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
250_I254_K5.2301.00
302_N387_S4.2701.00
218_N525_F3.9891.00
283_F291_E3.9051.00
269_E456_K3.8301.00
215_I529_E3.8231.00
316_I395_I3.3391.00
106_G135_K3.3341.00
393_D397_R3.2961.00
553_M558_K3.2441.00
268_V417_K3.1531.00
274_V408_K3.1221.00
249_K252_E3.1051.00
224_P469_I3.1051.00
408_K434_E3.0281.00
272_N410_S3.0101.00
276_L408_K2.9881.00
607_L624_R2.9481.00
386_N390_K2.9111.00
95_Q99_S2.8171.00
207_L505_L2.6871.00
144_K148_L2.6351.00
254_K258_N2.6121.00
414_Y454_L2.6011.00
264_T459_E2.5851.00
417_K420_D2.5751.00
602_C605_C2.5701.00
149_S153_N2.5621.00
224_P471_L2.5541.00
298_I390_K2.5161.00
503_E507_K2.4641.00
135_K156_A2.4501.00
214_E477_R2.4471.00
309_D388_K2.4361.00
274_V433_L2.3961.00
278_E406_D2.3871.00
55_V97_I2.3501.00
410_S433_L2.3461.00
258_N261_I2.3291.00
210_V511_L2.3171.00
72_V75_A2.2991.00
269_E415_T2.2791.00
455_S458_D2.2621.00
412_T431_K2.2621.00
301_Y305_R2.2601.00
57_A124_I2.2571.00
292_A391_I2.2491.00
560_L563_K2.2171.00
307_A316_I2.2091.00
211_V520_P2.1281.00
341_N346_K2.1141.00
301_Y503_E2.0961.00
259_K423_L2.0861.00
435_R439_D2.0731.00
263_K419_S2.0591.00
346_K349_D2.0411.00
109_N121_G2.0321.00
409_L432_I2.0241.00
266_K459_E2.0211.00
234_I458_D2.0081.00
53_V104_A1.9991.00
229_S240_N1.9821.00
550_K567_E1.9591.00
55_V96_L1.9401.00
225_K470_S1.9331.00
208_V212_N1.9241.00
275_R411_N1.9121.00
274_V410_S1.9121.00
407_A432_I1.9101.00
91_K95_Q1.8941.00
429_Y452_I1.8931.00
145_S149_S1.8821.00
297_G516_R1.8821.00
223_L248_E1.8801.00
76_D566_K1.8641.00
160_D557_G1.8601.00
298_I306_I1.8421.00
157_L162_I1.8401.00
222_P471_L1.8331.00
602_C622_K1.8191.00
601_K608_E1.8061.00
212_N216_E1.8031.00
415_T424_E1.7911.00
389_F393_D1.7881.00
111_C121_G1.7741.00
265_V416_L1.7681.00
554_I564_V1.7651.00
276_L406_D1.7571.00
605_C622_K1.7361.00
228_V253_A1.7241.00
609_Q630_E1.7161.00
155_S159_Y1.7071.00
248_E252_E1.7011.00
410_S431_K1.6921.00
506_V513_N1.6781.00
227_T470_S1.6761.00
215_I219_L1.6681.00
247_F256_F1.6621.00
486_W490_S1.6491.00
214_E520_P1.6481.00
268_V424_E1.6381.00
350_L439_D1.6281.00
546_D550_K1.6261.00
603_K630_E1.6171.00
415_T426_T1.6161.00
255_E259_K1.6091.00
408_K433_L1.6051.00
160_D163_N1.6051.00
99_S103_Y1.5921.00
396_A400_L1.5891.00
504_I508_R1.5851.00
38_N41_Y1.5841.00
55_V100_L1.5831.00
413_I428_S1.5761.00
266_K417_K1.5661.00
231_I464_D1.5651.00
265_V418_V1.5581.00
335_I378_G1.5581.00
296_Y390_K1.5531.00
429_Y451_P1.5531.00
270_V414_Y1.5391.00
291_E294_R1.5361.00
233_K463_V1.5361.00
298_I387_S1.5351.00
401_G441_Y1.5281.00
628_A631_I1.5281.00
267_V416_L1.5241.00
250_I469_I1.5171.00
486_W489_S1.5141.00
506_V518_I1.5021.00
39_V92_R1.5001.00
625_L628_A1.4981.00
94_Y127_N1.4911.00
566_K570_E1.4851.00
232_V241_I1.4751.00
407_A438_L1.4721.00
573_N577_E1.4711.00
198_S508_R1.4671.00
118_S122_Y1.4661.00
138_K155_S1.4461.00
550_K559_V1.4311.00
137_M151_F1.4271.00
231_I466_K1.4231.00
336_I400_L1.4191.00
252_E255_E1.3981.00
257_L261_I1.3971.00
251_T255_E1.3801.00
77_W566_K1.3781.00
257_L467_V1.3751.00
254_K257_L1.3711.00
600_V609_Q1.3711.00
328_S365_I1.3711.00
208_V532_N1.3641.00
326_I402_S1.3641.00
512_T521_T1.3601.00
292_A394_L1.3571.00
108_I154_I1.3561.00
272_N412_T1.3551.00
215_I218_N1.3521.00
578_E582_N1.3521.00
385_P388_K1.3521.00
53_V100_L1.3341.00
170_K565_I1.3321.00
553_M559_V1.3151.00
514_N519_I1.3071.00
241_I416_L1.3001.00
68_S80_L1.2991.00
549_S553_M1.2951.00
335_I338_G1.2951.00
305_R309_D1.2911.00
232_V416_L1.2911.00
473_K476_S1.2901.00
231_I240_N1.2861.00
95_Q98_S1.2771.00
417_K424_E1.2751.00
563_K566_K1.2721.00
298_I391_I1.2711.00
263_K418_V1.2681.00
92_R96_L1.2641.00
360_V363_Q1.2601.00
259_K419_S1.2511.00
239_L416_L1.2461.00
306_I387_S1.2461.00
409_L430_T1.2441.00
302_N305_R1.2431.00
338_G342_S1.2431.00
62_F127_N1.2391.00
125_I134_A1.2391.00
625_L629_V1.2351.00
416_L460_G1.2341.00
85_K94_Y1.2281.00
477_R520_P1.2261.00
119_V165_G1.2241.00
350_L435_R1.2161.00
198_S203_Q1.2161.00
215_I525_F1.2101.00
247_F253_A1.2091.00
211_V528_A1.2091.00
624_R627_D1.2041.00
214_E218_N1.2001.00
63_G169_H1.1991.00
277_L438_L1.1991.00
83_I94_Y1.1931.00
114_D370_A1.1921.00
608_E623_V1.1881.00
550_K553_M1.1871.00
381_P389_F1.1841.00
405_A434_E1.1791.00
92_R95_Q1.1691.00
316_I319_P1.1671.00
334_N338_G1.1651.00
315_L384_L1.1641.00
243_V423_L1.1571.00
101_S107_F1.1501.00
149_S152_R1.1451.00
164_A555_K1.1441.00
148_L152_R1.1441.00
332_I335_I1.1431.00
358_K406_D1.1411.00
234_I237_Y1.1371.00
306_I391_I1.1301.00
232_V265_V1.1271.00
313_D388_K1.1241.00
229_S468_N1.1181.00
337_K341_N1.1121.00
552_E555_K1.1101.00
600_V632_W1.1081.00
37_Y40_S1.1071.00
58_A93_Y1.1061.00
241_I427_V1.0991.00
462_I465_G1.0981.00
386_N389_F1.0971.00
159_Y163_N1.0971.00
238_S463_V1.0951.00
598_K608_E1.0951.00
231_I238_S1.0951.00
215_I532_N1.0941.00
156_A159_Y1.0941.00
265_V460_G1.0941.00
358_K361_V1.0901.00
597_I608_E1.0891.00
411_N428_S1.0881.00
600_V620_E1.0861.00
163_N561_E1.0790.99
511_L518_I1.0770.99
256_F423_L1.0730.99
167_A561_E1.0680.99
272_N453_F1.0640.99
234_I460_G1.0600.99
622_K628_A1.0570.99
139_F150_A1.0540.99
298_I302_N1.0540.99
260_L465_G1.0540.99
145_S329_T1.0530.99
137_M154_I1.0520.99
228_V256_F1.0470.99
513_N518_I1.0460.99
291_E295_I1.0450.99
69_G84_D1.0450.99
250_I467_V1.0410.99
520_P525_F1.0310.99
290_I485_K1.0300.99
227_T468_N1.0290.99
253_A467_V1.0270.99
233_K461_K1.0240.99
283_F398_R1.0230.99
325_K369_P1.0230.99
288_L303_V1.0220.99
298_I303_V1.0200.99
209_Q490_S1.0200.99
130_D133_K1.0190.99
291_E398_R1.0160.99
505_L511_L1.0160.99
623_V626_L1.0150.99
198_S504_I1.0140.99
167_A565_I1.0140.99
478_Y486_W1.0110.99
209_Q486_W1.0090.99
288_L307_A1.0080.99
292_A303_V1.0080.99
286_T495_E1.0070.99
93_Y96_L1.0060.99
357_G360_V1.0060.99
601_K606_D1.0050.99
477_R519_I1.0020.99
291_E394_L1.0010.99
361_V364_G0.9980.99
484_L502_I0.9960.99
387_S390_K0.9940.99
611_K614_L0.9920.99
228_V465_G0.9900.99
603_K609_Q0.9890.99
479_T517_Y0.9840.99
299_S302_N0.9840.99
277_L437_W0.9830.99
71_P74_D0.9830.99
416_L427_V0.9830.99
206_T487_M0.9820.99
230_I265_V0.9820.99
255_E258_N0.9820.99
413_I426_T0.9770.99
226_F469_I0.9750.99
604_Y630_E0.9740.99
300_P499_G0.9740.99
233_K236_D0.9710.99
217_R477_R0.9670.99
207_L524_G0.9630.99
563_K567_E0.9570.99
229_S242_K0.9570.99
118_S157_L0.9540.99
615_C618_H0.9530.99
627_D630_E0.9510.99
260_L418_V0.9460.99
334_N337_K0.9440.99
141_A146_D0.9420.99
257_L465_G0.9420.99
264_T461_K0.9380.99
574_K578_E0.9360.99
261_I464_D0.9330.99
265_V462_I0.9320.99
621_A626_L0.9310.99
163_N560_L0.9280.98
61_L127_N0.9270.98
546_D549_S0.9270.98
141_A327_P0.9260.98
233_K238_S0.9260.98
106_G133_K0.9210.98
230_I418_V0.9210.98
337_K351_V0.9200.98
622_K626_L0.9200.98
619_Y626_L0.9200.98
626_L631_I0.9160.98
626_L630_E0.9150.98
627_D631_I0.9130.98
338_G341_N0.9120.98
356_G360_V0.9120.98
211_V525_F0.9110.98
203_Q504_I0.9110.98
311_Y319_P0.9050.98
308_E312_L0.9050.98
150_A154_I0.9010.98
216_E478_Y0.9010.98
267_V414_Y0.9000.98
626_L629_V0.8990.98
350_L434_E0.8980.98
167_A554_I0.8980.98
302_N306_I0.8970.98
49_S52_Y0.8940.98
226_F250_I0.8940.98
622_K625_L0.8900.98
63_G86_N0.8890.98
213_S216_E0.8890.98
435_R442_H0.8880.98
254_K467_V0.8870.98
228_V257_L0.8850.98
624_R628_A0.8850.98
577_E580_K0.8820.98
113_Y147_I0.8770.98
272_N431_K0.8760.98
559_V563_K0.8740.98
454_L458_D0.8730.98
614_L617_Y0.8710.98
309_D313_D0.8710.98
619_Y623_V0.8700.98
621_A624_R0.8690.98
52_Y108_I0.8680.98
612_D621_A0.8650.98
359_Y363_Q0.8600.97
335_I339_L0.8590.97
599_I608_E0.8570.97
55_V93_Y0.8550.97
480_K513_N0.8540.97
597_I600_V0.8530.97
178_N573_N0.8530.97
74_D77_W0.8530.97
300_P484_L0.8520.97
619_Y625_L0.8520.97
179_V199_A0.8500.97
81_W166_I0.8490.97
609_Q612_D0.8480.97
227_T242_K0.8480.97
609_Q620_E0.8460.97
260_L425_F0.8460.97
358_K362_K0.8430.97
126_K129_G0.8420.97
570_E573_N0.8420.97
122_Y157_L0.8400.97
412_T429_Y0.8390.97
359_Y362_K0.8390.97
628_A632_W0.8380.97
604_Y623_V0.8370.97
107_F130_D0.8360.97
232_V425_F0.8360.97
203_Q508_R0.8320.97
611_K618_H0.8320.97
479_T482_S0.8310.97
113_Y140_S0.8310.97
612_D625_L0.8300.97
339_L344_Y0.8300.97
272_N456_K0.8290.97
409_L438_L0.8280.97
344_Y393_D0.8270.97
405_A408_K0.8260.97
53_V103_Y0.8250.97
309_D385_P0.8240.97
384_L388_K0.8230.97
256_F260_L0.8230.97
281_S324_Q0.8220.97
273_R411_N0.8210.97
621_A625_L0.8200.97
522_K526_Y0.8190.97
230_I465_G0.8170.97
98_S102_K0.8170.97
606_D609_Q0.8150.97
531_L539_V0.8120.96
185_I580_K0.8120.96
85_K91_K0.8110.96
337_K340_E0.8100.96
40_S96_L0.8100.96
288_L391_I0.8090.96
275_R409_L0.8070.96
596_L618_H0.8050.96
397_R442_H0.8050.96
268_V415_T0.8040.96
65_K82_E0.8030.96
300_P503_E0.8010.96
300_P480_K0.8000.96
300_P518_I0.8000.96
211_V215_I0.7990.96
214_E525_F0.7990.96
613_G618_H0.7980.96
270_V454_L0.7980.96
614_L619_Y0.7970.96
292_A296_Y0.7960.96
107_F132_K0.7950.96
609_Q614_L0.7930.96
487_M501_I0.7910.96
220_F472_S0.7910.96
122_Y162_I0.7900.96
612_D628_A0.7900.96
506_V511_L0.7890.96
101_S128_L0.7860.96
332_I336_I0.7830.96
113_Y138_K0.7800.96
620_E623_V0.7800.96
86_N91_K0.7790.96
407_A435_R0.7780.95
232_V418_V0.7770.95
599_I609_Q0.7760.95
577_E581_V0.7740.95
271_E413_I0.7710.95
481_V484_L0.7690.95
570_E574_K0.7690.95
547_M564_V0.7660.95
266_K457_G0.7650.95
609_Q628_A0.7640.95
414_Y453_F0.7590.95
600_V603_K0.7590.95
356_G359_Y0.7580.95
133_K156_A0.7580.95
87_S91_K0.7570.95
607_L620_E0.7560.95
232_V460_G0.7550.95
61_L94_Y0.7540.95
62_F94_Y0.7540.95
101_S125_I0.7530.95
107_F125_I0.7490.94
275_R407_A0.7490.94
225_K472_S0.7460.94
83_I86_N0.7450.94
141_A329_T0.7450.94
62_F126_K0.7450.94
608_E624_R0.7430.94
76_D562_S0.7360.94
380_A383_N0.7350.94
404_S440_I0.7350.94
567_E570_E0.7340.94
125_I130_D0.7340.94
500_R504_I0.7330.94
432_I438_L0.7320.94
232_V462_I0.7320.94
615_C619_Y0.7320.94
304_E499_G0.7300.94
267_V460_G0.7290.94
279_R358_K0.7290.94
604_Y609_Q0.7280.94
296_Y391_I0.7280.94
239_L243_V0.7270.94
295_I443_F0.7260.94
184_M196_I0.7250.93
271_E456_K0.7240.93
284_N324_Q0.7240.93
55_V58_A0.7220.93
300_P513_N0.7200.93
614_L618_H0.7200.93
364_G367_D0.7170.93
259_K420_D0.7170.93
612_D619_Y0.7150.93
286_T484_L0.7150.93
559_V567_E0.7150.93
621_A631_I0.7150.93
230_I425_F0.7140.93
629_V632_W0.7140.93
169_H173_W0.7130.93
619_Y628_A0.7130.93
69_G174_L0.7120.93
278_E361_V0.7100.93
623_V628_A0.7060.93
626_L632_W0.7060.93
284_N287_D0.7040.92
352_R357_G0.7040.92
600_V616_K0.7030.92
336_I399_F0.6990.92
504_I507_K0.6990.92
562_S566_K0.6980.92
208_V528_A0.6970.92
542_R546_D0.6960.92
326_I399_F0.6950.92
623_V627_D0.6950.92
576_I580_K0.6940.92
600_V618_H0.6930.92
323_S368_D0.6930.92
204_S531_L0.6920.92
97_I128_L0.6910.92
476_S517_Y0.6900.92
597_I623_V0.6900.92
143_T146_D0.6900.92
621_A628_A0.6880.92
71_P170_K0.6880.92
201_R544_T0.6880.92
109_N118_S0.6860.91
611_K620_E0.6820.91
100_L103_Y0.6810.91
625_L631_I0.6810.91
611_K628_A0.6800.91
575_F578_E0.6790.91
553_M556_T0.6780.91
192_K196_I0.6770.91
287_D290_I0.6760.91
391_I395_I0.6740.91
306_I388_K0.6740.91
230_I462_I0.6740.91
111_C118_S0.6740.91
599_I611_K0.6730.91
482_S486_W0.6720.91
620_E624_R0.6720.91
260_L263_K0.6710.91
385_P389_F0.6710.91
617_Y620_E0.6700.90
432_I435_R0.6700.90
605_C621_A0.6690.90
209_Q541_V0.6670.90
280_P294_R0.6650.90
132_K156_A0.6640.90
214_E217_R0.6630.90
358_K363_Q0.6620.90
299_S305_R0.6610.90
231_I463_V0.6600.90
622_K631_I0.6600.90
283_F394_L0.6580.90
334_N341_N0.6580.90
616_K619_Y0.6570.90
291_E441_Y0.6550.89
178_N576_I0.6540.89
490_S541_V0.6540.89
94_Y98_S0.6540.89
268_V456_K0.6520.89
243_V247_F0.6520.89
488_E495_E0.6500.89
627_D632_W0.6500.89
620_E630_E0.6490.89
480_K506_V0.6490.89
612_D623_V0.6480.89
372_P375_H0.6470.89
134_A156_A0.6470.89
568_N572_L0.6470.89
598_K620_E0.6460.89
612_D626_L0.6450.89
509_K512_T0.6450.89
611_K619_Y0.6440.89
304_E319_P0.6430.89
235_K458_D0.6420.89
170_K561_E0.6400.88
602_C609_Q0.6390.88
289_Q499_G0.6390.88
115_I551_L0.6390.88
512_T519_I0.6390.88
340_E345_R0.6380.88
603_K632_W0.6380.88
398_R441_Y0.6360.88
65_K84_D0.6350.88
125_I129_G0.6350.88
620_E626_L0.6350.88
619_Y627_D0.6350.88
600_V630_E0.6340.88
71_P77_W0.6320.88
115_I548_E0.6300.88
442_H445_N0.6300.88
610_Y624_R0.6300.88
108_I151_F0.6290.88
197_L523_L0.6290.88
548_E551_L0.6280.87
73_Y77_W0.6270.87
485_K489_S0.6260.87
332_I338_G0.6260.87
220_F475_T0.6250.87
615_C620_E0.6220.87
602_C628_A0.6220.87
610_Y623_V0.6200.87
237_Y243_V0.6200.87
75_A78_K0.6200.87
253_A257_L0.6190.87
79_P170_K0.6180.87
260_L265_V0.6180.87
537_D575_F0.6170.87
125_I156_A0.6170.87
572_L576_I0.6160.86
483_L502_I0.6160.86
270_V456_K0.6160.86
624_R630_E0.6160.86
277_L430_T0.6130.86
324_Q362_K0.6130.86
286_T290_I0.6120.86
322_N495_E0.6110.86
295_I441_Y0.6110.86
118_S121_G0.6110.86
356_G362_K0.6100.86
414_Y458_D0.6090.86
620_E632_W0.6090.86
598_K609_Q0.6090.86
94_Y128_L0.6080.86
552_E556_T0.6080.86
218_N520_P0.6080.86
326_I375_H0.6070.86
329_T335_I0.6070.86
619_Y622_K0.6060.86
605_C628_A0.6060.86
100_L104_A0.6060.86
397_R441_Y0.6050.85
180_S184_M0.6050.85
335_I340_E0.6050.85
212_N541_V0.6040.85
229_S466_K0.6030.85
600_V605_C0.6020.85
622_K627_D0.6010.85
245_K423_L0.6010.85
608_E612_D0.6000.85
442_H446_V0.5990.85
212_N532_N0.5990.85
597_I601_K0.5990.85
390_K393_D0.5990.85
57_A61_L0.5980.85
339_L343_S0.5980.85
425_F465_G0.5980.85
274_V412_T0.5980.85
434_E439_D0.5970.85
111_C122_Y0.5960.85
598_K632_W0.5960.85
356_G363_Q0.5960.85
247_F252_E0.5950.84
574_K577_E0.5950.84
327_P368_D0.5950.84
610_Y613_G0.5950.84
532_N539_V0.5940.84
96_L100_L0.5930.84
611_K623_V0.5930.84
159_Y162_I0.5930.84
138_K147_I0.5930.84
183_L527_I0.5930.84
65_K177_I0.5930.84
83_I127_N0.5910.84
65_K69_G0.5910.84
610_Y622_K0.5890.84
181_R184_M0.5890.84
600_V611_K0.5880.84
609_Q632_W0.5880.84
337_K352_R0.5880.84
606_D624_R0.5870.84
174_L178_N0.5870.84
357_G362_K0.5870.84
182_A576_I0.5860.84
277_L409_L0.5860.84
234_I239_L0.5840.83
163_N166_I0.5840.83
344_Y396_A0.5840.83
77_W565_I0.5830.83
93_Y100_L0.5830.83
245_K248_E0.5820.83
610_Y621_A0.5820.83
505_L509_K0.5810.83
470_S473_K0.5810.83
301_Y507_K0.5810.83
239_L454_L0.5800.83
608_E611_K0.5800.83
357_G361_V0.5770.83
599_I620_E0.5760.83
621_A627_D0.5750.82
597_I620_E0.5750.82
67_E177_I0.5750.82
380_A389_F0.5740.82
325_K367_D0.5740.82
180_S196_I0.5740.82
65_K70_F0.5740.82
307_A391_I0.5740.82
595_G627_D0.5730.82
624_R629_V0.5720.82
265_V465_G0.5720.82
602_C621_A0.5700.82
336_I339_L0.5690.82
438_L442_H0.5670.82
327_P330_I0.5670.82
357_G363_Q0.5670.82
454_L460_G0.5670.82
183_L579_Y0.5660.81
173_W177_I0.5660.81
349_D408_K0.5660.81
600_V610_Y0.5640.81
119_V123_L0.5640.81
279_R406_D0.5620.81
618_H624_R0.5620.81
256_F259_K0.5620.81
611_K624_R0.5610.81
513_N516_R0.5610.81
596_L620_E0.5600.81
360_V364_G0.5590.81
193_K530_I0.5590.81
445_N450_K0.5590.81
313_D383_N0.5580.81
284_N488_E0.5580.81
603_K620_E0.5580.81
183_L531_L0.5570.80
332_I339_L0.5560.80
418_V465_G0.5560.80
326_I373_A0.5550.80
84_D87_S0.5550.80
171_I547_M0.5540.80
600_V608_E0.5530.80
477_R517_Y0.5530.80
205_P505_L0.5520.80
352_R360_V0.5520.80
232_V454_L0.5520.80
290_I481_V0.5520.80
595_G612_D0.5510.80
270_V412_T0.5500.80
605_C619_Y0.5500.80
612_D615_C0.5490.79
222_P474_P0.5490.79
307_A395_I0.5490.79
616_K627_D0.5480.79
600_V623_V0.5480.79
239_L460_G0.5470.79
81_W165_G0.5470.79
179_V538_I0.5460.79
113_Y137_M0.5450.79
609_Q624_R0.5450.79
155_S161_M0.5440.79
109_N122_Y0.5440.79
624_R632_W0.5440.79
559_V564_V0.5440.79
607_L623_V0.5430.79
585_K588_E0.5420.79
565_I569_I0.5420.79
210_V520_P0.5410.78
336_I342_S0.5400.78
143_T330_I0.5400.78
431_K453_F0.5380.78
602_C610_Y0.5380.78
528_A532_N0.5380.78
256_F465_G0.5380.78
183_L199_A0.5370.78
41_Y48_N0.5370.78
228_V467_V0.5360.78
412_T452_I0.5360.78
135_K154_I0.5360.78
595_G610_Y0.5350.78
616_K620_E0.5330.77
605_C624_R0.5320.77
207_L528_A0.5320.77
619_Y624_R0.5320.77
139_F307_A0.5320.77
502_I506_V0.5310.77
36_K40_S0.5310.77
282_P362_K0.5310.77
193_K196_I0.5310.77
30_K105_L0.5310.77
596_L612_D0.5300.77
293_G299_S0.5300.77
313_D384_L0.5290.77
614_L627_D0.5290.77
315_L381_P0.5280.77
48_N103_Y0.5270.77
595_G603_K0.5270.77
266_K456_K0.5260.77
412_T451_P0.5260.77
282_P373_A0.5250.76
610_Y631_I0.5250.76
121_G124_I0.5250.76
79_P569_I0.5240.76
151_F154_I0.5230.76
500_R503_E0.5220.76
597_I611_K0.5210.76
212_N215_I0.5200.76
414_Y451_P0.5200.76
599_I610_Y0.5190.76
620_E625_L0.5190.76
623_V629_V0.5190.76
583_K587_G0.5190.76
62_F122_Y0.5180.75
229_S238_S0.5170.75
131_I134_A0.5170.75
317_S372_P0.5170.75
125_I131_I0.5160.75
146_D329_T0.5160.75
356_G361_V0.5160.75
294_R442_H0.5160.75
269_E464_D0.5150.75
299_S513_N0.5150.75
121_G157_L0.5150.75
599_I623_V0.5140.75
223_L246_E0.5140.75
604_Y629_V0.5140.75
624_R631_I0.5130.75
606_D610_Y0.5130.75
275_R430_T0.5130.75
583_K586_V0.5120.75
609_Q618_H0.5120.75
600_V624_R0.5120.75
285_L304_E0.5120.75
210_V300_P0.5100.74
166_I170_K0.5090.74
146_D150_A0.5090.74
526_Y529_E0.5090.74
601_K607_L0.5090.74
328_S334_N0.5070.74
137_M150_A0.5070.74
107_F134_A0.5070.74
620_E627_D0.5060.74
158_D161_M0.5050.74
143_T377_T0.5050.74
509_K523_L0.5050.74
173_W178_N0.5050.74
529_E533_K0.5050.74
111_C157_L0.5040.73
199_A204_S0.5040.73
74_D78_K0.5040.73
355_T358_K0.5040.73
111_C120_I0.5040.73
58_A97_I0.5040.73
571_K574_K0.5040.73
256_F425_F0.5040.73
623_V632_W0.5030.73
607_L610_Y0.5030.73
295_I300_P0.5020.73
121_G125_I0.5020.73
427_V451_P0.5020.73
140_S372_P0.5010.73
522_K525_F0.5010.73
228_V260_L0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cgyA 1 0.8743 100 0.181 Contact Map
1i7dA 1 0.8443 100 0.183 Contact Map
2gaiA 1 0.8428 100 0.214 Contact Map
1mw9X 1 0.7934 100 0.234 Contact Map
4dduA 1 0.7859 100 0.274 Contact Map
1gkuB 1 0.7575 100 0.281 Contact Map
1vddA 7 0.1781 99.3 0.929 Contact Map
2fcjA 2 0.1722 98.2 0.952 Contact Map
3vdpA 2 0.2246 97.4 0.96 Contact Map
2mc3A 1 0.1392 87.9 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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