GREMLIN Database
Q97ZJ7 - AAA family ATPase, p60 katanin
UniProt: Q97ZJ7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 372 (298)
Sequences: 12892 (7219)
Seq/√Len: 418.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
275_Y302_K5.7441.00
279_L298_E5.6471.00
283_K297_L5.1611.00
274_D277_Q3.6981.00
96_E99_K3.1771.00
287_S290_K2.7631.00
299_E303_L2.7501.00
102_F109_D2.7481.00
100_V103_K2.7391.00
98_P102_F2.6171.00
279_L283_K2.5891.00
275_Y298_E2.5531.00
280_S284_Y2.5441.00
104_D156_N2.5091.00
20_K24_E2.4701.00
283_K294_E2.4571.00
185_V202_I2.4491.00
293_T296_S2.4341.00
282_F312_I2.4091.00
67_R70_Y2.3521.00
280_S283_K2.3011.00
136_G232_M2.2861.00
248_G264_F2.2791.00
31_I34_Y2.2351.00
252_K255_R2.1061.00
203_F249_A2.0431.00
238_K241_N1.9451.00
31_I35_K1.9291.00
17_L21_A1.8731.00
60_M63_E1.8681.00
103_K156_N1.8441.00
97_K157_E1.7901.00
66_K70_Y1.7891.00
70_Y73_K1.7781.00
30_A33_Y1.7361.00
210_L228_F1.7211.00
313_R317_Q1.7141.00
51_S55_T1.7131.00
52_V56_A1.6761.00
47_L50_E1.6611.00
279_L294_E1.6461.00
75_L78_S1.6301.00
24_E28_E1.6251.00
278_R301_A1.6111.00
138_L264_F1.5881.00
154_V247_I1.5591.00
34_Y38_I1.5431.00
151_A247_I1.5391.00
139_L270_V1.5381.00
25_G28_E1.5111.00
26_K30_A1.5021.00
45_I48_Y1.5001.00
198_K243_K1.4891.00
21_A24_E1.4811.00
100_V157_E1.4611.00
34_Y37_A1.4551.00
46_V50_E1.4461.00
21_A28_E1.4391.00
173_K223_R1.4321.00
52_V55_T1.4141.00
63_E66_K1.4131.00
279_L297_L1.4121.00
227_Q231_E1.4011.00
74_V78_S1.3951.00
18_A22_D1.3891.00
29_D32_T1.3711.00
325_K329_K1.3701.00
298_E302_K1.3651.00
37_A40_V1.3561.00
63_E67_R1.3461.00
161_I197_N1.3411.00
41_L45_I1.3341.00
282_F297_L1.3331.00
261_L267_R1.3271.00
42_S46_V1.3191.00
96_E100_V1.3181.00
18_A21_A1.3161.00
22_D34_Y1.3111.00
106_V284_Y1.3101.00
27_V30_A1.3091.00
67_R71_L1.3041.00
35_K39_E1.2851.00
51_S54_R1.2821.00
40_V44_I1.2811.00
19_V23_K1.2701.00
43_Q47_L1.2691.00
26_K29_D1.2681.00
98_P113_E1.2591.00
27_V31_I1.2561.00
275_Y301_A1.2441.00
28_E32_T1.2411.00
30_A34_Y1.2351.00
33_Y37_A1.2341.00
315_I319_A1.2271.00
102_F112_K1.2181.00
63_E70_Y1.2181.00
163_M202_I1.2121.00
207_L248_G1.2041.00
34_Y39_E1.1941.00
18_A25_G1.1931.00
211_L260_F1.1891.00
32_T35_K1.1881.00
16_I19_V1.1831.00
289_I316_V1.1831.00
299_E302_K1.1781.00
231_E246_V1.1731.00
29_D33_Y1.1711.00
163_M200_A1.1701.00
23_K26_K1.1681.00
30_A35_K1.1511.00
21_A25_G1.1451.00
31_I36_K1.1391.00
16_I20_K1.1341.00
76_P80_D1.1301.00
55_T59_Q1.1261.00
262_R310_S1.1241.00
38_I42_S1.1221.00
39_E43_Q1.1211.00
22_D26_K1.1061.00
50_E54_R1.1041.00
140_Y250_T1.1031.00
151_A203_F1.0921.00
237_D241_N1.0911.00
28_E33_Y1.0901.00
27_V34_Y1.0821.00
158_I245_Y1.0811.00
42_S45_I1.0811.00
80_D83_G1.0791.00
44_I47_L1.0791.00
117_E322_K1.0781.00
285_Y288_K1.0681.00
27_V35_K1.0661.00
285_Y313_R1.0651.00
258_E261_L1.0641.00
68_I71_L1.0631.00
79_S83_G1.0591.00
53_A57_Y1.0531.00
112_K150_I1.0481.00
163_M189_A1.0441.00
33_Y36_K1.0381.00
75_L79_S1.0331.00
41_L44_I1.0301.00
32_T36_K1.0271.00
23_K30_A1.0241.00
110_D271_P1.0221.00
296_S299_E1.0211.00
76_P79_S1.0181.00
304_T312_I1.0101.00
109_D277_Q1.0091.00
18_A28_E1.0091.00
79_S84_D1.0061.00
165_L185_V1.0031.00
68_I72_E1.0031.00
138_L207_L0.9921.00
26_K35_K0.9911.00
88_P96_E0.9871.00
76_P83_G0.9871.00
39_E42_S0.9861.00
124_K129_F0.9851.00
55_T58_E0.9841.00
286_T316_V0.9831.00
31_I39_E0.9831.00
26_K33_Y0.9811.00
282_F300_L0.9771.00
75_L83_G0.9731.00
57_Y61_I0.9651.00
18_A26_K0.9631.00
167_A204_I0.9571.00
67_R73_K0.9541.00
271_P277_Q0.9521.00
17_L20_K0.9521.00
74_V77_A0.9511.00
28_E31_I0.9491.00
275_Y279_L0.9481.00
25_G35_K0.9471.00
79_S82_S0.9441.00
77_A82_S0.9421.00
25_G29_D0.9421.00
45_I49_P0.9411.00
35_K45_I0.9361.00
62_N65_K0.9351.00
104_D149_M0.9331.00
26_K32_T0.9261.00
75_L82_S0.9261.00
104_D153_A0.9231.00
18_A34_Y0.9181.00
21_A31_I0.9141.00
78_S83_G0.9131.00
109_D113_E0.9131.00
36_K39_E0.9091.00
46_V49_P0.9071.00
88_P191_E0.9061.00
27_V32_T0.9061.00
18_A33_Y0.9061.00
26_K31_I0.8971.00
23_K27_V0.8961.00
113_E117_E0.8901.00
187_K191_E0.8891.00
64_Y68_I0.8881.00
44_I48_Y0.8861.00
86_T89_P0.8841.00
25_G31_I0.8831.00
294_E298_E0.8781.00
311_D314_D0.8771.00
38_I43_Q0.8771.00
162_F203_F0.8761.00
295_V298_E0.8711.00
62_N66_K0.8691.00
18_A38_I0.8681.00
206_E251_N0.8681.00
83_G86_T0.8671.00
25_G30_A0.8621.00
303_L319_A0.8581.00
22_D25_G0.8571.00
27_V33_Y0.8571.00
19_V22_D0.8531.00
323_V327_M0.8501.00
41_L47_L0.8471.00
48_Y51_S0.8421.00
21_A33_Y0.8411.00
116_R120_I0.8411.00
30_A39_E0.8281.00
63_E73_K0.8261.00
85_N89_P0.8241.00
272_L308_T0.8241.00
150_I270_V0.8231.00
36_K40_V0.8201.00
82_S86_T0.8191.00
303_L315_I0.8191.00
23_K32_T0.8151.00
277_Q280_S0.8151.00
98_P329_K0.8121.00
129_F134_P0.8111.00
57_Y60_M0.8101.00
62_N70_Y0.8081.00
276_E279_L0.8061.00
35_K38_I0.8051.00
77_A81_G0.8031.00
66_K72_E0.7931.00
162_F201_I0.7901.00
100_V156_N0.7891.00
25_G34_Y0.7871.00
153_A156_N0.7821.00
21_A29_D0.7801.00
25_G33_Y0.7791.00
114_A268_I0.7771.00
321_I325_K0.7751.00
75_L80_D0.7721.00
18_A24_E0.7711.00
60_M64_Y0.7671.00
31_I38_I0.7671.00
40_V47_L0.7661.00
60_M67_R0.7631.00
39_E49_P0.7621.00
64_Y67_R0.7581.00
61_I64_Y0.7581.00
37_A41_L0.7571.00
39_E45_I0.7571.00
47_L51_S0.7571.00
38_I45_I0.7561.00
54_R58_E0.7561.00
81_G84_D0.7541.00
311_D315_I0.7531.00
17_L29_D0.7501.00
78_S84_D0.7501.00
65_K70_Y0.7451.00
253_P267_R0.7441.00
78_S81_G0.7421.00
206_E263_R0.7401.00
78_S82_S0.7371.00
80_D86_T0.7371.00
106_V280_S0.7341.00
110_D113_E0.7341.00
76_P82_S0.7331.00
66_K73_K0.7321.00
113_E325_K0.7311.00
56_A59_Q0.7291.00
170_V184_N0.7251.00
56_A60_M0.7251.00
74_V83_G0.7221.00
279_L301_A0.7211.00
317_Q321_I0.7201.00
163_M185_V0.7151.00
140_Y267_R0.7151.00
299_E319_A0.7101.00
16_I35_K0.7081.00
98_P120_I0.7071.00
253_P261_L0.7051.00
77_A84_D0.7041.00
35_K46_V0.7031.00
75_L81_G0.6981.00
32_T45_I0.6971.00
59_Q63_E0.6941.00
40_V43_Q0.6911.00
74_V80_D0.6911.00
52_V58_E0.6861.00
32_T39_E0.6861.00
24_E30_A0.6831.00
24_E27_V0.6811.00
59_Q67_R0.6761.00
36_K42_S0.6761.00
151_A162_F0.6741.00
67_R72_E0.6741.00
20_K27_V0.6711.00
104_D159_D0.6701.00
319_A323_V0.6680.99
83_G87_S0.6670.99
50_E59_Q0.6650.99
69_S72_E0.6630.99
22_D31_I0.6620.99
309_A312_I0.6620.99
23_K31_I0.6610.99
80_D84_D0.6600.99
95_T98_P0.6580.99
54_R57_Y0.6510.99
23_K35_K0.6500.99
82_S85_N0.6480.99
19_V26_K0.6480.99
315_I318_A0.6470.99
94_I98_P0.6460.99
43_Q50_E0.6460.99
64_Y71_L0.6410.99
28_E35_K0.6400.99
43_Q46_V0.6390.99
92_V96_E0.6380.99
42_S50_E0.6370.99
21_A27_V0.6370.99
282_F301_A0.6370.99
98_P325_K0.6360.99
21_A26_K0.6350.99
74_V79_S0.6340.99
45_I50_E0.6310.99
17_L36_K0.6280.99
161_I191_E0.6270.99
41_L46_V0.6250.99
61_I65_K0.6240.99
16_I21_A0.6230.99
74_V81_G0.6210.99
41_L49_P0.6200.99
66_K69_S0.6200.99
205_D263_R0.6190.99
59_Q62_N0.6190.99
111_V268_I0.6180.99
324_V328_F0.6130.99
316_V320_H0.6110.99
51_S58_E0.6090.99
29_D34_Y0.6090.99
53_A59_Q0.6080.99
82_S88_P0.6050.99
231_E237_D0.6050.99
17_L24_E0.6040.99
139_L154_V0.6040.99
41_L50_E0.6030.99
87_S243_K0.6030.99
76_P84_D0.6020.99
18_A45_I0.5980.99
82_S89_P0.5960.99
188_M197_N0.5930.99
50_E57_Y0.5920.99
18_A27_V0.5910.99
77_A80_D0.5890.99
53_A56_A0.5870.99
33_Y39_E0.5860.99
40_V45_I0.5850.99
22_D30_A0.5830.99
30_A36_K0.5830.99
281_L312_I0.5810.99
296_S301_A0.5800.99
66_K71_L0.5780.99
99_K103_K0.5780.99
94_I102_F0.5770.99
29_D38_I0.5770.99
36_K43_Q0.5750.98
27_V39_E0.5710.98
300_L319_A0.5680.98
97_K116_R0.5680.98
28_E39_E0.5680.98
35_K49_P0.5670.98
51_S59_Q0.5660.98
21_A45_I0.5650.98
171_M223_R0.5650.98
34_Y45_I0.5630.98
276_E298_E0.5620.98
34_Y43_Q0.5610.98
223_R226_N0.5590.98
54_R59_Q0.5570.98
36_K45_I0.5560.98
21_A30_A0.5550.98
42_S47_L0.5550.98
69_S73_K0.5540.98
322_K326_E0.5540.98
17_L28_E0.5540.98
114_A266_K0.5520.98
18_A29_D0.5520.98
86_T90_E0.5500.98
38_I47_L0.5500.98
81_G85_N0.5470.98
21_A34_Y0.5450.98
286_T297_L0.5450.98
42_S48_Y0.5430.98
37_A44_I0.5410.98
19_V27_V0.5400.98
48_Y52_V0.5380.98
23_K41_L0.5350.98
27_V36_K0.5350.98
22_D27_V0.5350.98
74_V82_S0.5340.98
22_D35_K0.5330.98
233_D313_R0.5330.98
34_Y42_S0.5320.98
56_A62_N0.5310.97
55_T61_I0.5310.97
84_D91_E0.5300.97
30_A45_I0.5290.97
300_L315_I0.5270.97
36_K41_L0.5260.97
32_T37_A0.5250.97
77_A83_G0.5250.97
18_A35_K0.5220.97
97_K100_V0.5220.97
61_I67_R0.5200.97
292_D295_V0.5190.97
20_K30_A0.5180.97
21_A35_K0.5170.97
295_V299_E0.5160.97
25_G49_P0.5160.97
183_A186_F0.5160.97
63_E71_L0.5160.97
282_F316_V0.5150.97
29_D37_A0.5130.97
25_G38_I0.5120.97
35_K40_V0.5120.97
21_A32_T0.5110.97
233_D263_R0.5100.97
189_A244_V0.5090.97
82_S90_E0.5080.97
20_K28_E0.5070.97
35_K41_L0.5060.97
66_K74_V0.5050.97
186_F198_K0.5050.97
39_E47_L0.5040.97
283_K287_S0.5030.97
225_R257_D0.5030.97
187_K190_R0.5020.96
143_P206_E0.5020.96
278_R282_F0.5010.96
87_S198_K0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cf2A 3 0.7823 100 0.374 Contact Map
4cr2J 1 0.9194 100 0.383 Contact Map
2zanA 1 0.7097 100 0.384 Contact Map
2qp9X 1 0.6828 100 0.401 Contact Map
4lcbA 1 0.6774 100 0.403 Contact Map
4cr2L 1 0.8978 100 0.405 Contact Map
3cf0A 3 0.7285 100 0.409 Contact Map
1xwiA 1 0.7366 100 0.41 Contact Map
3b9pA 1 0.7124 100 0.412 Contact Map
2ce7A 3 0.6855 100 0.419 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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