GREMLIN Database
ENO - Enolase
UniProt: Q97ZJ3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 419 (407)
Sequences: 3396 (1535)
Seq/√Len: 76.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
321_I325_K4.0691.00
15_I39_D3.5701.00
330_G357_K3.4981.00
26_V111_A3.3701.00
264_N296_Q3.3011.00
84_E87_I3.1741.00
271_L300_K3.1651.00
166_V238_G3.1081.00
99_E317_K3.1071.00
72_I103_K3.0331.00
320_K324_E3.0061.00
262_D265_Q2.9291.00
49_R318_Y2.7761.00
170_F179_A2.7551.00
67_D71_Y2.7491.00
183_V235_I2.6801.00
350_L354_N2.6241.00
193_E228_N2.6211.00
216_R276_Q2.6201.00
374_D400_K2.5711.00
177_L402_L2.5541.00
213_E217_E2.5461.00
32_D123_A2.5061.00
147_I222_I2.4891.00
88_I116_A2.4871.00
168_I236_Y2.3511.00
194_R224_T2.3221.00
227_N232_E2.3201.00
319_L331_V2.3161.00
114_I341_I2.3131.00
219_L223_Y2.2901.00
295_S299_N2.2771.00
86_G346_E2.2541.00
173_F177_L2.2501.00
184_Y390_A2.2151.00
400_K403_E2.2151.00
90_K94_D2.1521.00
48_T289_N2.1211.00
345_F379_I2.1071.00
80_I91_L2.0951.00
360_T381_S2.0761.00
312_Y328_T2.0721.00
49_R289_N2.0041.00
269_F273_L1.9931.00
71_Y75_P1.9931.00
118_K371_F1.9871.00
268_E300_K1.9861.00
129_F407_K1.9731.00
312_Y322_G1.9551.00
175_E178_F1.9081.00
145_L180_A1.9051.00
220_D277_Y1.9021.00
30_T82_V1.8681.00
73_I95_I1.8601.00
13_L406_N1.8591.00
25_R403_E1.8291.00
267_L286_F1.8231.00
289_N318_Y1.8071.00
267_L296_Q1.8021.00
10_V77_L1.7711.00
226_I237_M1.7351.00
272_D276_Q1.7321.00
275_K304_T1.7061.00
252_E256_I1.7031.00
179_A235_I1.6931.00
241_A270_Y1.6911.00
184_Y388_A1.6841.00
37_F400_K1.6701.00
14_E174_K1.6671.00
194_R221_L1.6601.00
253_K260_E1.6571.00
13_L25_R1.6221.00
261_L266_L1.6221.00
285_P297_L1.6151.00
11_K406_N1.6081.00
184_Y389_P1.6021.00
173_F402_L1.5981.00
48_T244_S1.5790.99
52_V102_S1.5760.99
348_T360_T1.5710.99
266_L270_Y1.5660.99
349_N353_R1.5590.99
236_Y280_V1.5590.99
271_L275_K1.5580.99
14_E61_T1.5510.99
238_G281_Y1.5480.99
348_T379_I1.5450.99
263_P293_M1.5400.99
27_F37_F1.5320.99
224_T227_N1.5320.99
319_L347_F1.4850.99
117_L341_I1.4850.99
194_R198_I1.4750.99
251_K260_E1.4660.99
39_D367_T1.4650.99
95_I104_L1.4620.99
80_I87_I1.4570.99
64_R67_D1.4490.99
295_S327_S1.4400.99
248_D252_E1.4170.99
189_G192_T1.4160.99
132_I378_G1.4000.99
178_F182_D1.3940.99
86_G342_S1.3920.99
27_F403_E1.3860.99
109_I340_T1.3730.98
268_E271_L1.3660.98
54_V64_R1.3640.98
188_K208_F1.3640.98
25_R400_K1.3630.98
368_E396_S1.3570.98
249_S252_E1.3540.98
349_N352_R1.3520.98
371_F375_F1.3510.98
265_Q268_E1.3470.98
320_K350_L1.3360.98
87_I91_L1.3220.98
216_R220_D1.3200.98
360_T376_A1.3140.98
73_I112_T1.3120.98
132_I345_F1.3050.98
285_P306_I1.3040.98
72_I75_P1.2890.98
6_S31_S1.2730.97
327_S356_M1.2670.97
163_F218_A1.2640.97
297_L301_L1.2630.97
127_E130_K1.2630.97
171_N179_A1.2630.97
28_I116_A1.2590.97
392_G395_T1.2570.97
86_G90_K1.2490.97
335_P341_I1.2470.97
144_L166_V1.2320.97
73_I104_L1.2310.97
40_A111_A1.2260.97
333_V348_T1.2190.97
29_R35_E1.2190.97
301_L305_I1.2180.97
86_G138_P1.2160.97
202_V390_A1.2130.97
68_I72_I1.2100.97
15_I367_T1.2080.97
316_I347_F1.2030.96
290_S293_M1.2010.96
92_L340_T1.1910.96
13_L27_F1.1870.96
316_I350_L1.1780.96
312_Y356_M1.1760.96
224_T228_N1.1670.96
221_L224_T1.1670.96
9_K74_D1.1650.96
190_L221_L1.1620.96
189_G193_E1.1620.96
83_R124_L1.1560.96
82_V116_A1.1540.96
144_L359_I1.1480.95
335_P375_F1.1480.95
156_N211_P1.1470.95
292_D325_K1.1450.95
294_F306_I1.1420.95
388_A395_T1.1420.95
345_F375_F1.1380.95
326_R356_M1.1280.95
74_D78_H1.1240.95
250_K254_Y1.1200.95
186_T189_G1.1170.95
244_S287_E1.1160.95
297_L306_I1.1150.95
295_S325_K1.1130.95
248_D253_K1.1120.95
54_V68_I1.1080.94
266_L286_F1.1050.94
248_D255_I1.1000.94
77_L80_I1.0970.94
254_Y261_L1.0950.94
272_D275_K1.0910.94
296_Q299_N1.0890.94
37_F403_E1.0880.94
117_L132_I1.0850.94
268_E272_D1.0810.94
27_F406_N1.0740.93
291_F327_S1.0720.93
299_N326_R1.0680.93
34_V123_A1.0650.93
160_I241_A1.0650.93
251_K254_Y1.0600.93
69_V111_A1.0600.93
274_V301_L1.0510.93
66_V70_N1.0500.93
186_T228_N1.0470.93
30_T34_V1.0440.92
179_A231_Y1.0420.92
126_L131_Y1.0420.92
82_V120_A1.0390.92
157_K215_T1.0390.92
176_A414_G1.0330.92
85_Q131_Y1.0310.92
316_I346_E1.0280.92
252_E255_I1.0230.92
11_K29_R1.0150.91
248_D254_Y1.0130.91
348_T352_R1.0130.91
194_R217_E1.0120.91
133_S137_L1.0070.91
92_L109_I1.0040.91
76_A95_I1.0010.91
286_F293_M0.9990.91
189_G228_N0.9970.91
101_K343_E0.9960.91
409_G412_Y0.9960.91
38_G114_I0.9940.90
248_D251_K0.9930.90
160_I273_L0.9750.90
98_T103_K0.9740.90
389_P395_T0.9740.90
25_R37_F0.9730.89
319_L356_M0.9730.89
91_L94_D0.9730.89
171_N175_E0.9720.89
216_R272_D0.9710.89
256_I259_R0.9680.89
358_L381_S0.9670.89
30_T33_G0.9660.89
13_L403_E0.9640.89
298_Q356_M0.9640.89
318_Y327_S0.9590.89
77_L116_A0.9560.89
114_I345_F0.9450.88
352_R358_L0.9430.88
296_Q300_K0.9420.88
223_Y226_I0.9410.88
281_Y383_F0.9390.88
13_L37_F0.9380.88
148_I158_L0.9380.88
118_K370_N0.9370.88
127_E407_K0.9370.88
318_Y321_I0.9300.87
176_A180_A0.9290.87
166_V359_I0.9280.87
34_V122_K0.9250.87
348_T358_L0.9250.87
182_D231_Y0.9240.87
368_E392_G0.9180.87
157_K212_L0.9170.87
322_G328_T0.9060.86
243_G246_F0.9060.86
328_T356_M0.9050.86
12_G69_V0.9020.86
155_G192_T0.9010.86
157_K211_P0.9010.86
26_V69_V0.8980.85
80_I88_I0.8980.85
215_T273_L0.8940.85
403_E406_N0.8930.85
90_K346_E0.8920.85
52_V100_N0.8890.85
28_I36_S0.8890.85
76_A91_L0.8880.85
264_N267_L0.8810.84
142_I414_G0.8800.84
72_I76_A0.8770.84
27_F35_E0.8770.84
170_F234_K0.8670.83
160_I269_F0.8650.83
274_V305_I0.8640.83
9_K29_R0.8630.83
323_I354_N0.8620.83
190_L224_T0.8570.83
63_K174_K0.8550.82
158_L215_T0.8510.82
83_R123_A0.8510.82
273_L279_I0.8500.82
166_V236_Y0.8500.82
132_I371_F0.8500.82
58_N63_K0.8490.82
264_N268_E0.8450.82
190_L228_N0.8440.82
155_G188_K0.8390.81
172_T405_E0.8380.81
311_L318_Y0.8350.81
172_T175_E0.8330.81
270_Y282_L0.8330.81
331_V351_A0.8310.81
134_G137_L0.8290.80
21_N185_R0.8180.80
133_S138_P0.8170.79
220_D223_Y0.8150.79
315_N338_V0.8150.79
8_E31_S0.8150.79
214_D217_E0.8140.79
174_K405_E0.8100.79
376_A384_I0.8090.79
198_I213_E0.8070.79
164_I307_T0.8070.79
286_F297_L0.8060.79
253_K256_I0.8030.78
138_P380_E0.8010.78
114_I371_F0.7960.78
319_L351_A0.7960.78
250_K256_I0.7950.78
171_N178_F0.7900.77
181_I389_P0.7850.77
11_K70_N0.7850.77
70_N75_P0.7840.77
219_L239_M0.7830.77
160_I215_T0.7820.76
49_R321_I0.7800.76
179_A234_K0.7790.76
155_G199_Y0.7780.76
136_R346_E0.7780.76
68_I104_L0.7750.76
99_E102_S0.7740.76
217_E220_D0.7730.76
13_L400_K0.7720.75
14_E63_K0.7710.75
16_V177_L0.7690.75
118_K122_K0.7660.75
331_V347_F0.7660.75
249_S254_Y0.7660.75
370_N392_G0.7630.75
255_I260_E0.7630.75
36_S122_K0.7620.75
370_N395_T0.7620.75
91_L95_I0.7620.75
341_I371_F0.7620.75
157_K160_I0.7580.74
106_G110_I0.7580.74
157_K213_E0.7540.74
241_A282_L0.7530.74
267_L300_K0.7530.74
212_L221_L0.7530.74
160_I239_M0.7530.74
10_V74_D0.7480.73
333_V344_T0.7470.73
157_K214_D0.7450.73
267_L297_L0.7440.73
114_I118_K0.7430.73
158_L211_P0.7430.73
212_L218_A0.7420.73
174_K406_N0.7420.73
77_L88_I0.7400.72
321_I324_E0.7390.72
341_I375_F0.7380.72
14_E181_I0.7330.72
271_L274_V0.7260.71
246_F270_Y0.7260.71
152_L245_D0.7240.71
16_V178_F0.7220.71
139_K380_E0.7220.71
130_K407_K0.7220.71
352_R380_E0.7210.70
10_V28_I0.7200.70
254_Y258_G0.7190.70
223_Y277_Y0.7180.70
269_F272_D0.7180.70
177_L181_I0.7170.70
241_A287_E0.7160.70
345_F381_S0.7150.70
155_G158_L0.7130.70
152_L192_T0.7110.69
241_A246_F0.7100.69
147_I183_V0.7090.69
52_V93_K0.7090.69
358_L379_I0.7080.69
317_K321_I0.7080.69
184_Y202_V0.7010.68
30_T123_A0.7000.68
27_F39_D0.6990.68
152_L241_A0.6970.68
138_P346_E0.6960.68
135_P345_F0.6940.67
347_F358_L0.6930.67
263_P286_F0.6910.67
271_L304_T0.6880.67
183_V186_T0.6880.67
27_F400_K0.6880.67
165_I235_I0.6850.66
139_K413_E0.6840.66
222_I237_M0.6790.66
223_Y237_M0.6790.66
263_P267_L0.6780.66
346_E349_N0.6760.65
134_G138_P0.6760.65
31_S82_V0.6750.65
249_S253_K0.6750.65
165_I222_I0.6740.65
126_L130_K0.6730.65
157_K198_I0.6710.65
136_R380_E0.6710.65
93_K340_T0.6710.65
24_I69_V0.6690.65
292_D295_S0.6660.64
241_A266_L0.6650.64
148_I222_I0.6630.64
40_A110_I0.6630.64
267_L301_L0.6630.64
285_P294_F0.6620.64
147_I165_I0.6620.64
274_V297_L0.6620.64
9_K78_H0.6600.64
6_S81_D0.6600.64
174_K177_L0.6590.63
286_F301_L0.6590.63
83_R120_A0.6590.63
48_T288_E0.6590.63
198_I201_A0.6570.63
24_I111_A0.6570.63
77_L91_L0.6560.63
400_K406_N0.6550.63
11_K27_F0.6550.63
330_G359_I0.6540.63
323_I350_L0.6530.63
132_I360_T0.6520.63
237_M241_A0.6520.63
247_Y287_E0.6520.63
216_R277_Y0.6510.63
335_P344_T0.6450.62
30_T35_E0.6420.61
170_F176_A0.6410.61
243_G287_E0.6410.61
130_K134_G0.6410.61
120_A131_Y0.6400.61
252_E257_D0.6360.61
117_L371_F0.6340.61
298_Q326_R0.6340.61
254_Y259_R0.6290.60
82_V88_I0.6280.60
253_K257_D0.6260.60
243_G270_Y0.6250.59
28_I115_A0.6230.59
245_D386_V0.6230.59
270_Y273_L0.6230.59
87_I90_K0.6220.59
316_I320_K0.6200.59
138_P349_N0.6200.59
165_I183_V0.6180.59
48_T318_Y0.6180.59
360_T375_F0.6170.58
178_F231_Y0.6160.58
270_Y297_L0.6160.58
268_E296_Q0.6150.58
76_A80_I0.6150.58
88_I93_K0.6130.58
116_A120_A0.6120.58
162_E362_H0.6110.58
34_V82_V0.6110.58
410_L413_E0.6110.58
250_K253_K0.6110.58
274_V304_T0.6100.58
295_S326_R0.6090.57
145_L389_P0.6080.57
83_R116_A0.6050.57
137_L380_E0.6050.57
58_N178_F0.6040.57
294_F328_T0.6030.57
32_D82_V0.6030.57
160_I218_A0.6030.57
271_L301_L0.6020.57
103_K340_T0.5990.56
247_Y250_K0.5970.56
27_F36_S0.5970.56
155_G191_I0.5970.56
249_S287_E0.5970.56
63_K67_D0.5960.56
264_N292_D0.5960.56
360_T379_I0.5940.56
163_F212_L0.5930.55
311_L327_S0.5930.55
408_F412_Y0.5920.55
237_M279_I0.5900.55
144_L238_G0.5900.55
180_A235_I0.5880.55
324_E350_L0.5880.55
250_K255_I0.5870.55
16_V181_I0.5870.55
302_S305_I0.5870.55
36_S119_T0.5860.55
68_I108_T0.5850.54
157_K221_L0.5850.54
6_S125_G0.5850.54
155_G198_I0.5840.54
291_F321_I0.5840.54
32_D125_G0.5830.54
30_T119_T0.5830.54
198_I217_E0.5820.54
38_G115_A0.5810.54
16_V389_P0.5810.54
70_N74_D0.5800.54
256_I266_L0.5770.53
152_L287_E0.5760.53
137_L140_I0.5760.53
166_V180_A0.5750.53
30_T36_S0.5740.53
8_E29_R0.5740.53
158_L256_I0.5740.53
203_G362_H0.5730.53
306_I327_S0.5710.53
65_A108_T0.5700.53
35_E122_K0.5690.52
81_D120_A0.5680.52
333_V360_T0.5670.52
10_V27_F0.5670.52
368_E384_I0.5670.52
191_I221_L0.5660.52
148_I160_I0.5660.52
86_G411_E0.5650.52
31_S81_D0.5640.52
66_V69_V0.5640.52
12_G24_I0.5630.52
49_R287_E0.5630.52
193_E224_T0.5630.52
48_T287_E0.5630.52
158_L176_A0.5630.52
289_N321_I0.5620.52
254_Y257_D0.5600.51
190_L225_S0.5600.51
101_K109_I0.5580.51
39_D406_N0.5560.51
215_T241_A0.5560.51
166_V241_A0.5550.51
138_P413_E0.5540.51
157_K201_A0.5540.51
122_K125_G0.5540.51
146_N149_N0.5530.50
170_F177_L0.5530.50
130_K411_E0.5520.50
82_V123_A0.5520.50
156_N256_I0.5520.50
93_K101_K0.5500.50
86_G349_N0.5500.50
348_T381_S0.5500.50
72_I104_L0.5500.50
331_V356_M0.5500.50
325_K356_M0.5490.50
312_Y327_S0.5490.50
135_P138_P0.5490.50
148_I221_L0.5490.50
169_K179_A0.5480.50
90_K342_S0.5480.50
164_I238_G0.5460.50
398_Y401_L0.5460.50
341_I345_F0.5460.50
149_N203_G0.5460.50
25_R406_N0.5440.49
158_L221_L0.5430.49
71_Y78_H0.5430.49
32_D35_E0.5420.49
156_N208_F0.5410.49
255_I259_R0.5370.48
153_H362_H0.5360.48
285_P327_S0.5360.48
211_P215_T0.5350.48
174_K402_L0.5340.48
190_L194_R0.5330.48
43_G47_G0.5320.48
117_L128_V0.5320.48
168_I280_V0.5320.48
345_F349_N0.5310.48
319_L333_V0.5310.48
166_V280_V0.5310.48
26_V116_A0.5300.48
170_F175_E0.5290.47
198_I221_L0.5290.47
250_K257_D0.5290.47
215_T246_F0.5280.47
268_E275_K0.5250.47
261_L265_Q0.5250.47
162_E203_G0.5250.47
86_G136_R0.5250.47
25_R39_D0.5230.47
217_E221_L0.5220.47
15_I24_I0.5220.47
245_D313_T0.5220.47
117_L378_G0.5190.46
26_V112_T0.5180.46
359_I383_F0.5180.46
21_N60_L0.5180.46
92_L104_L0.5180.46
143_P176_A0.5180.46
24_I368_E0.5170.46
142_I166_V0.5170.46
191_I198_I0.5170.46
11_K262_D0.5160.46
186_T229_A0.5150.46
15_I368_E0.5150.46
245_D375_F0.5140.45
372_I375_F0.5140.45
37_F406_N0.5130.45
219_L237_M0.5120.45
129_F408_F0.5110.45
8_E12_G0.5100.45
10_V92_L0.5100.45
149_N162_E0.5080.45
215_T257_D0.5080.45
187_L203_G0.5080.45
165_I389_P0.5070.45
29_R34_V0.5070.45
281_Y359_I0.5070.45
152_L246_F0.5060.44
291_F318_Y0.5050.44
409_G414_G0.5040.44
316_I319_L0.5040.44
15_I37_F0.5030.44
144_L237_M0.5020.44
155_G215_T0.5020.44
153_H205_E0.5010.44
45_S50_E0.5010.44
176_A181_I0.5000.44
320_K346_E0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mksA 3 0.926 100 0.311 Contact Map
2akzA 2 0.9833 100 0.332 Contact Map
3otrA 2 0.9881 100 0.335 Contact Map
1w6tA 3 0.9833 100 0.344 Contact Map
3tqpA 2 0.9666 100 0.349 Contact Map
2pa6A 5 0.9905 100 0.354 Contact Map
3uj2A 3 0.9833 100 0.368 Contact Map
4ywsA 2 0.9523 100 0.375 Contact Map
4ropA 3 0.9833 100 0.377 Contact Map
2fymA 3 0.9857 100 0.385 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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