GREMLIN Database
GCSPB - Probable glycine dehydrogenase (decarboxylating) subunit 2
UniProt: Q97ZI9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 508 (406)
Sequences: 5271 (2737)
Seq/√Len: 135.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
240_I245_A3.6551.00
238_K242_S3.4541.00
262_R265_D3.3141.00
374_V453_K3.1761.00
237_S247_L3.1601.00
135_D296_K3.1071.00
177_H225_T3.0721.00
98_A343_A3.0341.00
32_E36_Q3.0291.00
378_E393_S2.9451.00
354_Q358_K2.8841.00
370_K449_A2.8381.00
252_A292_A2.8291.00
134_M271_V2.8051.00
211_V239_I2.6951.00
367_L436_P2.6681.00
297_G300_V2.6541.00
119_E123_E2.5781.00
206_I210_I2.5031.00
255_N360_S2.4941.00
369_A372_R2.4901.00
261_A265_D2.4781.00
155_I270_I2.2851.00
170_I217_G2.2741.00
234_L238_K2.2521.00
234_L261_A2.1501.00
63_V93_K2.1071.00
258_L353_I2.1041.00
415_N454_K2.1021.00
169_T212_N2.0781.00
152_V219_M2.0271.00
237_S266_M2.0191.00
137_C294_C2.0041.00
253_N388_H1.9811.00
333_G336_G1.9781.00
87_T439_T1.9431.00
57_L65_H1.9351.00
370_K373_D1.9281.00
58_S61_E1.9091.00
31_E40_M1.9011.00
276_H292_A1.8961.00
367_L445_L1.8931.00
308_V317_L1.8691.00
394_V408_V1.8251.00
367_L390_V1.8011.00
334_N337_N1.7981.00
169_T214_K1.7971.00
235_E238_K1.7821.00
394_V405_A1.7811.00
181_P186_M1.7801.00
195_K206_I1.7721.00
85_S289_G1.7641.00
122_Y315_Y1.7541.00
92_P95_E1.7501.00
155_I248_Y1.7411.00
43_P48_R1.7351.00
90_Y340_R1.7261.00
86_C435_E1.7091.00
136_E300_V1.7061.00
419_A448_F1.7051.00
61_E441_T1.7011.00
132_T273_L1.6991.00
205_D208_R1.6901.00
206_I209_E1.6791.00
366_Y442_K1.6741.00
367_L449_A1.6641.00
359_M363_A1.6631.00
43_P46_L1.6621.00
218_F240_I1.6551.00
120_M339_A1.6541.00
417_F451_T1.6471.00
170_I219_M1.6351.00
238_K241_H1.6351.00
158_Y299_L1.6311.00
211_V215_T1.6281.00
36_Q40_M1.6251.00
122_Y310_K1.6021.00
442_K446_D1.6011.00
94_I347_G1.6011.00
229_F260_I1.6001.00
171_L210_I1.5751.00
391_V431_A1.5741.00
363_A445_L1.5631.00
423_Y431_A1.5401.00
74_F79_G1.5351.00
220_L233_I1.5241.00
135_D297_G1.5191.00
172_V184_A1.5181.00
420_P433_M1.5121.00
43_P47_L1.5121.00
127_W346_L1.5071.00
208_R235_E1.5061.00
246_V298_E1.5061.00
197_N201_L1.5011.00
208_R239_I1.4871.00
176_A184_A1.4871.00
333_G337_N1.4741.00
262_R266_M1.4731.00
44_K47_L1.4601.00
368_I386_R1.4521.00
120_M342_F1.4431.00
364_T390_V1.4411.00
370_K450_E1.4361.00
175_T226_L1.4311.00
85_S283_H1.4121.00
234_L266_M1.4041.00
126_N129_S1.4021.00
368_I379_L1.3961.00
224_N230_E1.3941.00
159_H164_R1.3921.00
99_T340_R1.3911.00
77_D416_G1.3851.00
129_S137_C1.3751.00
335_V339_A1.3731.00
109_E114_I1.3711.00
248_Y273_L1.3711.00
371_L452_L1.3681.00
78_I444_T1.3671.00
148_E219_M1.3521.00
123_E342_F1.3471.00
391_V433_M1.3401.00
129_S135_D1.3391.00
173_A202_V1.3371.00
370_K453_K1.3301.00
348_L356_I1.3251.00
370_K446_D1.3241.00
157_K302_Y1.3241.00
205_D209_E1.3231.00
364_T436_P1.3151.00
168_D190_K1.3141.00
169_T190_K1.3121.00
410_K414_D1.3091.00
80_I444_T1.3001.00
121_I139_L1.2971.00
47_L50_N1.2911.00
409_A413_L1.2881.00
219_M251_G1.2761.00
295_A299_L1.2711.00
39_E47_L1.2611.00
240_I247_L1.2581.00
43_P50_N1.2571.00
169_T215_T1.2541.00
361_T365_N1.2481.00
168_D214_K1.2431.00
152_V170_I1.2421.00
212_N243_T1.2401.00
65_H69_L1.2301.00
124_L338_L1.2271.00
365_N386_R1.2201.00
411_A415_N1.2201.00
155_I217_G1.2191.00
87_T437_T1.2071.00
377_L392_F1.2011.00
176_A221_T1.2001.00
406_N421_T1.1971.00
301_N323_N1.1901.00
220_L247_L1.1850.99
280_A348_L1.1840.99
87_T440_E1.1820.99
380_I393_S1.1820.99
115_Q118_L1.1760.99
213_D243_T1.1730.99
351_Q355_M1.1730.99
95_E280_A1.1700.99
380_I431_A1.1620.99
436_P440_E1.1510.99
222_N260_I1.1460.99
109_E113_Y1.1460.99
42_I47_L1.1310.99
74_F416_G1.1260.99
80_I417_F1.1260.99
164_R167_K1.1160.99
318_S321_P1.1090.99
67_V70_S1.1080.99
174_D193_Y1.1070.99
44_K49_E1.1030.99
273_L293_I1.1010.99
169_T197_N1.0980.99
254_L276_H1.0960.99
293_I303_L1.0940.99
440_E444_T1.0930.99
86_C437_T1.0880.99
222_N266_M1.0870.99
151_G270_I1.0860.99
409_A421_T1.0820.99
86_C177_H1.0770.99
253_N278_T1.0750.99
117_I335_V1.0730.99
342_F346_L1.0710.99
366_Y446_D1.0700.99
449_A453_K1.0690.99
175_T224_N1.0660.99
364_T386_R1.0630.99
54_L57_L1.0630.99
417_F447_M1.0550.99
126_N130_E1.0510.99
133_G262_R1.0510.99
176_A219_M1.0470.99
211_V243_T1.0460.99
237_S241_H1.0420.99
343_A347_G1.0410.99
128_F294_C1.0380.99
241_H245_A1.0340.99
305_Y324_S1.0280.99
411_A414_D1.0270.99
241_H247_L1.0210.98
174_D195_K1.0190.98
363_A442_K1.0170.98
261_A266_M1.0070.98
231_E234_L1.0050.98
434_I448_F1.0040.98
415_N447_M1.0010.98
122_Y125_Q0.9990.98
159_H163_N0.9970.98
166_Y214_K0.9960.98
135_D295_A0.9940.98
155_I246_V0.9930.98
259_G361_T0.9870.98
125_Q136_E0.9860.98
220_L237_S0.9840.98
203_D206_I0.9770.98
102_T105_H0.9710.98
88_M283_H0.9630.98
415_N451_T0.9590.98
67_V71_Q0.9570.98
120_M343_A0.9550.98
360_S388_H0.9540.98
142_P329_A0.9530.98
250_D266_M0.9480.98
254_L273_L0.9470.98
48_R51_E0.9460.97
221_T251_G0.9430.97
31_E36_Q0.9370.97
290_A338_L0.9340.97
217_G248_Y0.9280.97
171_L205_D0.9270.97
281_V337_N0.9260.97
404_S407_D0.9210.97
127_W345_I0.9200.97
154_M295_A0.9200.97
405_A409_A0.9180.97
78_I447_M0.9160.97
224_N228_L0.9150.97
447_M451_T0.9150.97
237_S250_D0.9150.97
172_V176_A0.9100.97
65_H68_R0.9050.97
167_K244_N0.9040.97
409_A432_L0.9040.97
393_S431_A0.9030.97
105_H336_G0.9030.97
355_M358_K0.9000.97
154_M293_I0.8980.97
123_E127_W0.8970.97
233_I266_M0.8960.97
212_N215_T0.8940.96
83_L177_H0.8930.96
368_I372_R0.8910.96
393_S430_E0.8890.96
290_A341_S0.8850.96
169_T192_M0.8810.96
252_A256_G0.8800.96
421_T424_F0.8780.96
71_Q78_I0.8770.96
355_M359_M0.8760.96
135_D298_E0.8740.96
337_N340_R0.8740.96
371_L377_L0.8700.96
121_I332_Y0.8680.96
80_I440_E0.8660.96
123_E346_L0.8660.96
208_R242_S0.8650.96
74_F77_D0.8620.96
252_A276_H0.8610.96
138_S293_I0.8590.96
89_K439_T0.8580.96
392_F434_I0.8520.95
171_L215_T0.8510.95
361_T386_R0.8500.95
204_M208_R0.8480.95
124_L276_H0.8470.95
42_I46_L0.8440.95
121_I290_A0.8390.95
135_D300_V0.8390.95
154_M325_I0.8380.95
450_E453_K0.8370.95
77_D413_L0.8370.95
87_T283_H0.8350.95
222_N256_G0.8350.95
222_N229_F0.8350.95
134_M264_G0.8350.95
60_L89_K0.8340.95
138_S150_A0.8320.95
344_Y356_I0.8300.95
94_I343_A0.8290.95
155_I170_I0.8280.95
407_D410_K0.8280.95
274_N292_A0.8260.95
254_L258_L0.8240.94
309_E318_S0.8190.94
260_I358_K0.8190.94
218_F236_I0.8180.94
185_A188_G0.8150.94
231_E235_E0.8110.94
276_H290_A0.8080.94
129_S134_M0.8040.94
364_T435_E0.8030.94
395_K405_A0.8030.94
412_L419_A0.8010.94
61_E443_E0.8010.94
96_E340_R0.7990.94
351_Q358_K0.7980.93
137_C293_I0.7960.93
412_L417_F0.7950.93
406_N410_K0.7930.93
305_Y321_P0.7920.93
83_L225_T0.7910.93
241_H246_V0.7860.93
167_K216_A0.7860.93
173_A207_L0.7840.93
305_Y320_I0.7800.93
230_E233_I0.7790.93
62_V66_F0.7790.93
33_I36_Q0.7790.93
134_M268_F0.7790.93
114_I118_L0.7780.93
415_N450_E0.7780.93
206_I211_V0.7760.93
296_K299_L0.7750.92
371_L392_F0.7740.92
83_L433_M0.7730.92
79_G283_H0.7730.92
307_M327_K0.7680.92
152_V183_S0.7660.92
108_L306_P0.7650.92
448_F452_L0.7650.92
258_L356_I0.7630.92
363_A436_P0.7610.92
344_Y348_L0.7580.92
228_L384_R0.7580.92
392_F452_L0.7570.92
136_E307_M0.7570.92
187_A202_V0.7570.92
26_L31_E0.7560.92
194_V210_I0.7550.91
154_M158_Y0.7550.91
283_H289_G0.7550.91
405_A422_I0.7540.91
417_F444_T0.7540.91
80_I436_P0.7540.91
201_L384_R0.7540.91
417_F448_F0.7520.91
124_L290_A0.7510.91
302_Y323_N0.7510.91
156_K216_A0.7500.91
130_E262_R0.7480.91
131_I345_I0.7460.91
68_R71_Q0.7430.91
148_E183_S0.7410.91
183_S251_G0.7400.91
374_V377_L0.7390.91
345_I353_I0.7360.90
239_I243_T0.7340.90
128_F276_H0.7330.90
158_Y302_Y0.7270.90
48_R52_P0.7270.90
276_H279_F0.7260.90
311_V316_K0.7260.90
441_T444_T0.7260.90
411_A455_I0.7260.90
280_A337_N0.7240.90
439_T444_T0.7230.90
368_I377_L0.7230.90
156_K168_D0.7220.90
332_Y335_V0.7220.90
239_I242_S0.7210.89
118_L122_Y0.7170.89
130_E350_P0.7160.89
446_D450_E0.7160.89
204_M210_I0.7140.89
80_I448_F0.7140.89
380_I391_V0.7120.89
70_S77_D0.7100.89
356_I360_S0.7070.89
281_V340_R0.7070.89
28_N31_E0.7060.88
235_E239_I0.7060.88
379_L392_F0.7050.88
246_V299_L0.7040.88
181_P185_A0.7030.88
201_L204_M0.7030.88
131_I353_I0.7030.88
446_D449_A0.7020.88
204_M207_L0.7010.88
150_A328_I0.7000.88
367_L371_L0.7000.88
295_A303_L0.6980.88
57_L62_V0.6960.88
138_S303_L0.6950.88
386_R390_V0.6930.88
305_Y323_N0.6930.88
85_S146_A0.6910.87
443_E446_D0.6910.87
443_E447_M0.6910.87
362_L366_Y0.6870.87
157_K325_I0.6870.87
31_E37_I0.6870.87
305_Y311_V0.6860.87
374_V449_A0.6850.87
327_K330_T0.6840.87
422_I433_M0.6840.87
96_E100_A0.6820.87
184_A188_G0.6820.87
175_T228_L0.6810.87
233_I250_D0.6790.86
181_P193_Y0.6780.86
390_V434_I0.6780.86
367_L448_F0.6760.86
408_V452_L0.6700.86
306_P327_K0.6700.86
27_I32_E0.6690.86
250_D271_V0.6690.86
50_N53_D0.6670.86
413_L419_A0.6660.85
379_L383_N0.6640.85
125_Q307_M0.6620.85
174_D196_S0.6610.85
170_I216_A0.6590.85
90_Y95_E0.6580.85
187_A219_M0.6580.85
233_I237_S0.6520.84
165_N216_A0.6510.84
396_Q407_D0.6480.84
332_Y336_G0.6460.84
404_S408_V0.6440.83
225_T420_P0.6420.83
89_K92_P0.6410.83
152_V184_A0.6390.83
250_D268_F0.6380.83
419_A433_M0.6380.83
114_I332_Y0.6380.83
250_D262_R0.6350.83
125_Q139_L0.6340.83
159_H167_K0.6330.82
259_G357_G0.6320.82
358_K362_L0.6290.82
152_V191_V0.6290.82
380_I383_N0.6270.82
259_G358_K0.6260.82
207_L210_I0.6260.82
247_L268_F0.6250.82
374_V454_K0.6240.82
169_T203_D0.6240.82
39_E44_K0.6240.82
171_L194_V0.6240.82
310_K315_Y0.6230.81
79_G87_T0.6210.81
412_L415_N0.6210.81
350_P353_I0.6210.81
320_I325_I0.6200.81
158_Y295_A0.6180.81
363_A366_Y0.6180.81
134_M294_C0.6180.81
396_Q425_P0.6170.81
108_L309_E0.6140.80
115_Q122_Y0.6140.80
128_F138_S0.6140.80
148_E251_G0.6110.80
275_L292_A0.6100.80
372_R379_L0.6020.79
42_I48_R0.6020.79
217_G245_A0.6000.79
405_A408_V0.6000.79
46_L50_N0.5990.79
76_V79_G0.5980.79
201_L228_L0.5950.78
321_P324_S0.5940.78
343_A346_L0.5940.78
373_D453_K0.5920.78
141_V293_I0.5920.78
440_E445_L0.5920.78
450_E454_K0.5920.78
275_L291_G0.5910.78
305_Y319_K0.5900.78
306_P309_E0.5900.78
252_A271_V0.5880.78
305_Y322_K0.5880.78
418_Y421_T0.5850.77
153_L196_S0.5840.77
131_I254_L0.5840.77
406_N422_I0.5830.77
181_P189_Y0.5830.77
154_M270_I0.5800.77
199_E231_E0.5790.77
211_V240_I0.5760.76
305_Y327_K0.5760.76
35_S39_E0.5760.76
146_A329_A0.5750.76
380_I392_F0.5740.76
436_P445_L0.5730.76
121_I338_L0.5720.76
258_L357_G0.5690.75
171_L203_D0.5680.75
255_N344_Y0.5670.75
83_L86_C0.5660.75
145_S186_M0.5660.75
64_R89_K0.5660.75
372_R378_E0.5640.75
390_V436_P0.5640.75
368_I390_V0.5640.75
141_V291_G0.5630.75
108_L331_F0.5630.75
158_Y296_K0.5630.75
91_N282_P0.5630.75
301_N321_P0.5590.74
367_L434_I0.5570.74
421_T425_P0.5570.74
309_E316_K0.5570.74
125_Q332_Y0.5570.74
175_T202_V0.5560.74
202_V207_L0.5560.74
158_Y246_V0.5550.73
220_L236_I0.5540.73
305_Y318_S0.5510.73
159_H246_V0.5500.73
309_E332_Y0.5490.73
83_L420_P0.5480.73
41_K47_L0.5480.73
396_Q404_S0.5470.72
219_M248_Y0.5460.72
184_A204_M0.5460.72
204_M239_I0.5440.72
224_N391_V0.5430.72
376_E396_Q0.5420.72
350_P354_Q0.5410.72
112_D115_Q0.5410.72
422_I425_P0.5410.72
420_P429_E0.5410.72
370_K374_V0.5400.71
153_L157_K0.5400.71
226_L391_V0.5380.71
257_V266_M0.5370.71
360_S364_T0.5350.71
192_M210_I0.5350.71
310_K313_G0.5350.71
120_M338_L0.5340.71
112_D118_L0.5340.71
155_I159_H0.5330.70
95_E99_T0.5330.70
270_I302_Y0.5320.70
322_K325_I0.5310.70
151_G248_Y0.5310.70
393_S425_P0.5310.70
172_V219_M0.5300.70
411_A454_K0.5300.70
207_L211_V0.5280.70
273_L339_A0.5280.70
83_L435_E0.5280.70
270_I293_I0.5270.70
255_N279_F0.5250.69
183_S186_M0.5240.69
98_A347_G0.5240.69
428_V431_A0.5230.69
98_A101_I0.5230.69
372_R384_R0.5220.69
125_Q325_I0.5220.69
159_H165_N0.5210.69
366_Y449_A0.5210.69
436_P439_T0.5200.69
177_H224_N0.5200.69
245_A248_Y0.5200.69
229_F361_T0.5200.69
45_N49_E0.5200.69
118_L308_V0.5200.69
189_Y193_Y0.5190.68
183_S187_A0.5190.68
377_L394_V0.5190.68
190_K195_K0.5190.68
204_M211_V0.5180.68
301_N322_K0.5180.68
405_A432_L0.5180.68
112_D309_E0.5180.68
434_I452_L0.5170.68
154_M333_G0.5170.68
79_G82_P0.5160.68
172_V187_A0.5150.68
378_E395_K0.5130.68
183_S189_Y0.5110.67
257_V263_P0.5110.67
365_N369_A0.5100.67
281_V284_G0.5100.67
365_N368_I0.5100.67
254_L275_L0.5100.67
119_E309_E0.5090.67
279_F360_S0.5090.67
112_D311_V0.5080.67
122_Y126_N0.5070.67
148_E184_A0.5060.67
228_L383_N0.5050.66
65_H110_D0.5050.66
186_M190_K0.5050.66
207_L236_I0.5040.66
171_L240_I0.5030.66
133_G264_G0.5030.66
262_R271_V0.5020.66
115_Q324_S0.5020.66
307_M317_L0.5020.66
115_Q305_Y0.5010.66
204_M209_E0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lhdA 2 0.9272 100 0.59 Contact Map
1wyuB 2 0.9193 100 0.606 Contact Map
1wyuA 2 0.8189 100 0.665 Contact Map
3mc6A 2 0.7795 100 0.772 Contact Map
3wcnA 2 0.7933 100 0.8 Contact Map
3hl2A 3 0.7638 100 0.81 Contact Map
3bc8A 3 0.7579 100 0.814 Contact Map
2z67A 4 0.7638 100 0.818 Contact Map
4obuE 2 0.8366 100 0.831 Contact Map
2jisA 2 0.8248 100 0.834 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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