GREMLIN Database
GCSPA - Probable glycine dehydrogenase (decarboxylating) subunit 1
UniProt: Q97ZI8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 455 (398)
Sequences: 5190 (2719)
Seq/√Len: 136.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
233_D237_H3.5581.00
256_P259_S3.4241.00
379_I446_Q3.3141.00
130_D289_R3.1851.00
359_R363_E3.0581.00
166_N220_F3.0531.00
158_T183_K2.9801.00
205_S234_V2.8961.00
129_M265_V2.8791.00
91_I348_V2.8511.00
375_R442_V2.8481.00
246_V285_I2.7311.00
150_A297_Q2.7301.00
235_A240_A2.6751.00
372_A429_V2.6711.00
200_D204_K2.6591.00
290_W295_V2.6261.00
114_Q118_E2.6121.00
374_K377_T2.5361.00
383_I397_K2.4841.00
249_L365_I2.4591.00
170_K186_E2.4111.00
255_K259_S2.3861.00
158_T185_E2.3261.00
159_V212_A2.2621.00
229_E233_D2.2421.00
412_R447_E2.2161.00
160_L187_V2.1931.00
229_E255_K2.1861.00
232_I242_S2.1771.00
252_G358_I2.1091.00
163_E188_K2.0861.00
132_V287_A2.0621.00
232_I260_Y2.0291.00
398_F405_I2.0001.00
165_A170_K2.0001.00
157_K183_K1.9871.00
50_L58_E1.9581.00
158_T207_S1.9471.00
147_V214_Y1.9431.00
247_N392_E1.9281.00
81_P432_V1.9181.00
375_R378_E1.8941.00
188_K200_D1.8941.00
51_S54_E1.8921.00
421_S424_T1.8911.00
269_G285_I1.8801.00
372_A394_F1.8401.00
372_A438_I1.8251.00
416_G441_L1.8081.00
131_V295_V1.8021.00
56_E87_A1.7991.00
372_A442_V1.7811.00
398_F402_Y1.7801.00
84_I345_A1.7561.00
158_T209_D1.7541.00
79_I282_L1.7481.00
54_E434_D1.7481.00
115_A344_L1.7191.00
117_F315_F1.7081.00
127_L266_V1.7001.00
230_H233_D1.6931.00
150_A324_Q1.6851.00
213_I235_A1.6781.00
202_E230_H1.6741.00
417_G426_L1.6711.00
435_K439_D1.6521.00
80_C428_C1.6461.00
364_E368_R1.6371.00
72_P437_S1.6301.00
122_L351_S1.6251.00
215_V228_I1.6251.00
371_Y435_K1.6131.00
414_L444_T1.6131.00
205_S210_V1.6041.00
117_F305_I1.5991.00
159_V214_Y1.5961.00
130_D290_W1.5951.00
233_D236_K1.5911.00
406_N418_L1.5781.00
101_Y109_S1.5721.00
224_F254_I1.5671.00
67_V73_P1.5621.00
395_V424_T1.5601.00
368_R438_I1.5531.00
202_E234_V1.5391.00
163_E186_E1.5261.00
150_A243_I1.5161.00
373_A390_F1.5141.00
375_R443_S1.4901.00
397_K423_H1.4761.00
340_A344_L1.4751.00
79_I276_L1.4651.00
121_S124_A1.4601.00
115_A347_A1.4601.00
369_S394_F1.4501.00
27_D31_D1.4261.00
229_E260_Y1.4241.00
164_N221_F1.4231.00
207_S238_K1.4211.00
288_V294_L1.4111.00
243_I262_A1.3991.00
105_Q109_S1.3921.00
256_P260_Y1.3921.00
219_N225_E1.3901.00
148_L151_N1.3831.00
395_V426_L1.3621.00
92_I345_A1.3621.00
147_V159_V1.3621.00
353_L361_L1.3581.00
157_K209_D1.3551.00
227_N230_H1.3491.00
118_E347_A1.3491.00
153_I294_L1.3481.00
215_V242_S1.3451.00
69_L413_K1.3431.00
214_Y245_G1.3261.00
162_P196_V1.3251.00
375_R446_Q1.3241.00
124_A132_V1.3121.00
124_A130_D1.3091.00
243_I266_V1.3041.00
158_T210_V1.3021.00
376_L445_I1.2991.00
274_L342_L1.2961.00
406_N416_G1.2931.00
369_S429_V1.2871.00
205_S238_K1.2871.00
116_L134_A1.2831.00
160_L204_K1.2821.00
200_D203_K1.2741.00
58_E62_K1.2711.00
375_R439_D1.2711.00
370_H390_F1.2701.00
401_E404_I1.2641.00
74_F437_S1.2611.00
30_N37_K1.2551.00
169_H245_G1.2411.00
165_A216_Q1.2381.00
119_Y343_A1.2311.00
366_Y370_H1.2241.00
112_I340_A1.2241.00
88_V348_V1.2231.00
409_L416_G1.2071.00
110_Q113_L1.2011.00
273_G353_L1.1971.00
81_P430_T1.1961.00
60_Y63_V1.1951.00
74_F414_L1.1931.00
162_P189_Y1.1921.00
408_K411_E1.1891.00
88_V352_L1.1810.99
429_V433_H1.1790.99
202_E237_H1.1780.99
208_N238_K1.1770.99
95_S98_Y1.1770.99
407_D411_E1.1660.99
144_A264_I1.1660.99
34_A37_K1.1630.99
67_V413_K1.1620.99
160_L185_E1.1600.99
408_K412_R1.1590.99
81_P433_H1.1550.99
348_V352_L1.1510.99
34_A39_N1.1450.99
83_Y432_V1.1440.99
146_A149_M1.1290.99
395_V420_L1.1270.99
286_F298_M1.1270.99
442_V446_Q1.1210.99
121_S125_E1.1200.99
371_Y439_D1.1190.99
356_E360_E1.1160.99
80_C166_N1.1070.99
217_Q260_Y1.1010.99
128_E256_P1.1000.99
414_L440_L1.0970.99
164_N219_N1.0960.99
266_V286_F1.0940.99
406_N410_K1.0940.99
99_T341_L1.0890.99
101_Y112_I1.0890.99
105_Q108_I1.0870.99
347_A351_S1.0860.99
360_E363_E1.0830.99
148_L153_I1.0810.99
369_S390_F1.0800.99
232_I241_L1.0760.99
148_L182_I1.0720.99
72_P440_L1.0690.99
80_C430_T1.0670.99
248_P269_G1.0630.99
217_Q254_I1.0600.99
117_F120_Q1.0490.99
420_L426_L1.0470.99
403_N418_L1.0410.99
433_H437_S1.0400.99
247_N271_E1.0400.99
123_M287_A1.0280.99
427_F441_L1.0240.99
143_L214_Y1.0140.98
165_A214_Y1.0140.98
255_K260_Y1.0100.98
145_E149_M1.0050.98
235_A242_S1.0030.98
244_I260_Y1.0020.98
382_V396_I1.0000.98
27_D30_N0.9990.98
368_R435_K0.9990.98
120_Q131_V0.9980.98
412_R440_L0.9950.98
198_I227_N0.9950.98
152_R297_Q0.9880.98
232_I236_K0.9800.98
87_A352_L0.9740.98
130_D288_V0.9730.98
150_A264_I0.9690.98
248_P266_V0.9660.98
89_K92_I0.9650.98
60_Y64_K0.9590.98
115_A348_V0.9590.98
130_D295_V0.9530.98
253_L366_Y0.9500.98
69_L410_K0.9490.98
296_R324_Q0.9460.98
232_I244_I0.9450.98
228_I260_Y0.9420.97
118_E122_L0.9400.97
440_L444_T0.9320.97
283_M343_A0.9300.97
365_I392_E0.9300.97
373_A377_T0.9290.97
236_K242_S0.9270.97
77_A166_N0.9250.97
397_K424_T0.9250.97
58_E61_E0.9210.97
396_I427_F0.9190.97
215_V232_I0.9180.97
149_M154_N0.9160.97
82_H276_L0.9150.97
360_E364_E0.9150.97
137_Y330_K0.9150.97
216_Q245_G0.9100.97
219_N223_I0.9090.97
283_M346_N0.9080.97
161_V165_A0.9010.97
155_G209_D0.8990.97
412_R444_T0.8950.97
376_L382_V0.8930.96
402_Y406_N0.8930.96
300_G328_R0.8910.96
104_Y336_T0.8880.96
406_N425_S0.8860.96
37_K40_R0.8840.96
133_N286_F0.8840.96
118_E351_S0.8830.96
116_L283_M0.8820.96
207_S210_V0.8810.96
116_L337_T0.8810.96
122_L350_L0.8800.96
109_S113_L0.8770.96
213_I231_I0.8760.96
150_A212_A0.8750.96
190_D225_E0.8730.96
198_I234_V0.8710.96
187_V204_K0.8700.96
342_L345_A0.8690.96
212_A243_I0.8680.96
150_A241_L0.8640.96
246_V250_S0.8600.96
254_I363_E0.8540.95
386_F424_T0.8540.95
366_Y390_F0.8490.95
443_S446_Q0.8450.95
273_G342_L0.8450.95
441_L445_I0.8430.95
68_E72_P0.8430.95
217_Q250_S0.8420.95
246_V269_G0.8410.95
349_Y361_L0.8410.95
74_F433_H0.8380.95
81_P276_L0.8380.95
356_E363_E0.8320.95
248_P252_G0.8320.95
143_L169_H0.8310.95
223_I388_S0.8310.95
420_L423_H0.8300.95
400_I423_H0.8290.95
301_R336_T0.8260.95
129_M258_G0.8260.95
289_R294_L0.8180.94
94_R97_F0.8150.94
143_L286_F0.8140.94
401_E423_H0.8100.94
267_G285_I0.8090.94
197_D200_D0.8070.94
350_L358_I0.8060.94
399_P402_Y0.8060.94
217_Q224_F0.8030.94
225_E228_I0.8030.94
243_I260_Y0.7990.94
156_K211_S0.7980.94
376_L396_I0.7980.94
73_P276_L0.7980.94
269_G283_M0.7950.93
77_A220_F0.7930.93
368_R429_V0.7920.93
126_L350_L0.7920.93
147_V177_I0.7900.93
404_I407_D0.7890.93
129_M262_A0.7890.93
410_K416_G0.7880.93
124_A129_M0.7870.93
390_F394_F0.7850.93
131_V302_I0.7840.93
54_E436_K0.7830.93
414_L437_S0.7820.93
119_Y269_G0.7810.93
55_I59_I0.7800.93
104_Y301_R0.7780.93
243_I251_L0.7770.93
53_Y83_Y0.7770.93
161_V170_K0.7770.93
38_I42_L0.7760.93
182_I212_A0.7760.93
412_R443_S0.7750.93
252_G361_L0.7740.92
164_N189_Y0.7730.92
113_L117_F0.7730.92
30_N34_A0.7710.92
369_S428_C0.7680.92
235_A239_K0.7680.92
77_A426_L0.7680.92
165_A186_E0.7670.92
398_F401_E0.7670.92
125_E256_P0.7630.92
132_V286_F0.7620.92
439_D443_S0.7600.92
163_E189_Y0.7590.92
416_G426_L0.7590.92
149_M153_I0.7590.92
160_L210_V0.7570.92
401_E405_I0.7560.92
234_V238_K0.7560.92
349_Y353_L0.7500.91
91_I94_R0.7460.91
126_L358_I0.7450.91
230_H234_V0.7430.91
77_A418_L0.7410.91
288_V298_M0.7390.91
169_H216_Q0.7380.91
276_L282_L0.7370.91
153_I156_K0.7360.90
439_D442_V0.7360.90
50_L55_I0.7320.90
153_I297_Q0.7300.90
198_I202_E0.7300.90
327_K330_K0.7300.90
33_P36_I0.7300.90
119_Y283_M0.7270.90
101_Y107_E0.7260.90
101_Y105_Q0.7230.90
89_K93_G0.7230.90
234_V237_H0.7220.90
64_K72_P0.7220.90
302_I331_A0.7190.89
394_F427_F0.7180.89
74_F429_V0.7180.89
417_G420_L0.7170.89
77_A417_G0.7170.89
403_N407_D0.7160.89
400_I408_K0.7150.89
109_S337_T0.7140.89
244_I262_A0.7100.89
386_F397_K0.7090.89
300_G306_T0.7090.89
29_F32_I0.7080.89
123_M269_G0.7070.89
372_A376_L0.7060.89
436_K440_L0.7040.88
434_D437_S0.7040.88
89_K345_A0.7040.88
61_E64_K0.7030.88
300_G321_T0.7030.88
150_A159_V0.7030.88
361_L365_I0.7030.88
151_N211_S0.7030.88
164_N223_I0.7030.88
244_I256_P0.7030.88
274_L345_A0.7020.88
133_N298_M0.7020.88
110_Q117_F0.7000.88
74_F441_L0.6980.88
185_E204_K0.6980.88
83_Y86_N0.6950.88
436_K439_D0.6930.88
414_L441_L0.6900.87
183_K209_D0.6900.87
149_M288_V0.6890.87
120_Q302_I0.6870.87
372_A441_L0.6850.87
400_I404_I0.6850.87
228_I244_I0.6850.87
79_I141_S0.6840.87
305_I313_M0.6770.86
164_N196_V0.6760.86
379_I442_V0.6750.86
159_V211_S0.6730.86
244_I265_V0.6720.86
367_F371_Y0.6720.86
107_E110_Q0.6710.86
396_I445_I0.6700.86
408_K448_A0.6700.86
300_G322_R0.6690.86
269_G272_L0.6680.86
304_G337_T0.6670.86
125_E355_K0.6670.86
306_T314_G0.6620.85
189_Y221_F0.6610.85
432_V437_S0.6600.85
399_P423_H0.6590.85
302_I322_R0.6580.85
212_A239_K0.6570.85
86_N89_K0.6560.85
320_Q325_F0.6540.84
26_D37_K0.6490.84
196_V231_I0.6480.84
405_I445_I0.6460.84
355_K359_R0.6440.84
75_I415_Q0.6430.83
348_V351_S0.6420.83
268_D285_I0.6420.83
363_E367_F0.6410.83
220_F417_G0.6400.83
368_R371_Y0.6350.83
38_I41_L0.6350.83
409_L414_L0.6340.83
159_V182_I0.6330.83
40_R43_K0.6330.83
236_K240_A0.6330.83
377_T380_D0.6320.82
89_K273_G0.6310.82
301_R304_G0.6270.82
378_E446_Q0.6270.82
268_D284_G0.6250.82
32_I37_K0.6240.82
115_A340_A0.6210.81
116_L343_A0.6190.81
380_D405_I0.6140.81
355_K358_I0.6140.81
144_A212_A0.6120.80
194_G386_F0.6120.80
120_Q134_A0.6110.80
300_G331_A0.6090.80
129_M287_A0.6090.80
73_P81_P0.6070.80
433_H438_I0.6070.80
228_I232_I0.6050.80
188_K191_K0.6020.79
44_V49_P0.5990.79
253_L363_E0.5960.79
136_M286_F0.5960.79
297_Q324_Q0.5940.78
373_A394_F0.5940.78
375_R379_I0.5930.78
402_Y425_S0.5910.78
253_L362_A0.5910.78
161_V214_Y0.5880.78
420_L424_T0.5880.78
246_V265_V0.5880.78
72_P414_L0.5870.78
93_G99_T0.5870.78
202_E205_S0.5860.77
89_K97_F0.5810.77
73_P76_G0.5810.77
300_G323_E0.5810.77
402_Y421_S0.5790.77
383_I386_F0.5790.77
380_D445_I0.5780.77
210_V234_V0.5780.77
252_G362_A0.5760.76
205_S235_A0.5760.76
123_M133_N0.5760.76
149_M264_I0.5730.76
136_M284_G0.5730.76
109_S328_R0.5720.76
374_K378_E0.5720.76
249_L349_Y0.5710.76
264_I297_Q0.5690.75
429_V438_I0.5680.75
57_K83_Y0.5660.75
339_E342_L0.5660.75
404_I408_K0.5640.75
236_K241_L0.5630.75
383_I399_P0.5630.75
394_F429_V0.5620.75
266_V344_L0.5620.75
300_G330_K0.5580.74
427_F445_I0.5570.74
26_D30_N0.5570.74
308_D311_N0.5560.74
159_V243_I0.5560.74
40_R44_V0.5550.74
400_I405_I0.5550.74
58_E106_P0.5540.73
69_L73_P0.5530.73
249_L252_G0.5520.73
90_F95_S0.5520.73
169_H214_Y0.5520.73
224_F366_Y0.5510.73
113_L303_V0.5510.73
128_E258_G0.5510.73
307_R311_N0.5500.73
365_I369_S0.5500.73
101_Y304_G0.5500.73
177_I182_I0.5480.73
251_L255_K0.5480.73
89_K95_S0.5480.73
45_A48_K0.5460.72
115_A343_A0.5450.72
129_M243_I0.5440.72
377_T387_T0.5430.72
382_V398_F0.5430.72
372_A427_F0.5420.72
262_A265_V0.5410.72
370_H373_A0.5400.72
373_A382_V0.5390.71
289_R295_V0.5390.71
104_Y330_K0.5380.71
307_R313_M0.5380.71
251_L260_Y0.5370.71
104_Y304_G0.5370.71
110_Q114_Q0.5350.71
113_L308_D0.5330.71
254_I359_R0.5330.71
376_L380_D0.5320.70
443_S447_E0.5310.70
301_R328_R0.5310.70
155_G208_N0.5310.70
296_R323_E0.5300.70
126_L248_P0.5290.70
151_N182_I0.5280.70
410_K418_L0.5280.70
73_P415_Q0.5270.70
93_G97_F0.5270.70
147_V212_A0.5260.70
353_L358_I0.5260.70
154_N211_S0.5250.69
136_M335_I0.5250.69
163_E221_F0.5250.69
296_R322_R0.5250.69
300_G320_Q0.5240.69
151_N155_G0.5240.69
77_A80_C0.5230.69
162_P219_N0.5230.69
194_G219_N0.5230.69
371_Y375_R0.5220.69
429_V432_V0.5220.69
272_L365_I0.5210.69
408_K447_E0.5210.69
312_N315_F0.5210.69
221_F395_V0.5210.69
120_Q337_T0.5210.69
117_F121_S0.5190.69
101_Y330_K0.5190.69
379_I382_V0.5190.69
37_K42_L0.5190.69
107_E113_L0.5170.68
49_P55_I0.5160.68
313_M316_T0.5160.68
107_E304_G0.5160.68
109_S304_G0.5150.68
402_Y405_I0.5150.68
219_N395_V0.5150.68
274_L277_N0.5130.68
88_V91_I0.5130.68
90_F93_G0.5130.68
249_L272_L0.5130.68
369_S373_A0.5120.68
215_V231_I0.5110.67
416_G425_S0.5110.67
251_L257_P0.5110.67
241_L294_L0.5100.67
28_L31_D0.5070.67
274_L346_N0.5070.67
107_E333_S0.5060.67
189_Y225_E0.5060.67
107_E306_T0.5060.67
308_D312_N0.5050.67
155_G183_K0.5050.67
220_F418_L0.5020.66
72_P433_H0.5020.66
371_Y442_V0.5020.66
405_I448_A0.5010.66
228_I242_S0.5000.66
271_E392_E0.5000.66
140_G170_K0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lhdA 2 0.9516 100 0.465 Contact Map
1wyuA 2 0.9495 100 0.588 Contact Map
1wyuB 2 0.9099 100 0.668 Contact Map
3mc6A 2 0.8286 100 0.75 Contact Map
3wcnA 2 0.8879 100 0.775 Contact Map
3hl2A 3 0.8374 100 0.794 Contact Map
3bc8A 3 0.8154 100 0.8 Contact Map
4obuE 2 0.8769 100 0.81 Contact Map
2z67A 4 0.8374 100 0.811 Contact Map
2jisA 2 0.9033 100 0.812 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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