Q97ZI7 - SULSO - GREMLIN Contacts

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Q97ZI7 - Aminomethyltransferase

UniProt:	Q97ZI7	Sequences: MFVSPFHDVEEKLGANFGEFAGWEMPMSFTSYAEEHMCVRNSVAFFNLSHMGRLRVKGNPREFEMLVAKEVNKANSGIMIGPTAFLNDKAGFKDDVMVYKVSENEWLIVTNAINREKIVNWIKSNSNLDVEDLTFKYGMIAIQGRKLEEILGKNELKQLEFKLNTRFMGYDVFLISRSGWTGENGLEVWVTLDVGRQLMMDLVKIGIKPAGLIARDSLRQEMGFVLYGEDIDETITPVEARYWVFSLEKDFIGKDSLVERIRSGIDKVRIGFKMRKGERTIPRHQSKIYSIGNEVGYVTSSTFSPYLNRVIGMGYVNPKYFYLGYSLTGEIRGKQYDIKIDEFPFI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	346 (338)
Sequences:	7141 (4693)
Seq/√Len:	255.2

ECOLI - GCST YGFZ
BACSU - GCST
HALSA - GCST Q9HM98
SULSO - Q97ZI7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
9_V	200_M	3.736	1.00
146_K	149_E	3.685	1.00
273_K	309_R	3.304	1.00
287_K	294_E	3.285	1.00
43_V	150_I	3.136	1.00
236_T	260_R	3.084	1.00
55_R	105_E	3.032	1.00
328_T	335_Q	2.797	1.00
259_E	263_S	2.719	1.00
7_H	11_E	2.681	1.00
11_E	17_F	2.532	1.00
288_I	314_G	2.504	1.00
37_M	41_N	2.488	1.00
138_G	195_G	2.487	1.00
272_F	312_G	2.479	1.00
42_S	146_K	2.473	1.00
326_S	337_D	2.327	1.00
57_K	105_E	2.215	1.00
44_A	210_A	2.174	1.00
275_R	339_K	2.158	1.00
330_E	335_Q	2.150	1.00
39_V	44_A	2.132	1.00
64_E	70_E	2.107	1.00
12_K	200_M	2.089	1.00
66_L	122_I	2.075	1.00
273_K	339_K	2.071	1.00
285_Q	297_Y	2.060	1.00
330_E	333_G	2.026	1.00
304_S	307_L	2.009	1.00
289_Y	335_Q	2.003	1.00
290_S	293_N	2.001	1.00
229_E	284_H	2.000	1.00
76_S	100_K	1.992	1.00
8_D	12_K	1.987	1.00
328_T	337_D	1.978	1.00
8_D	11_E	1.961	1.00
250_D	254_K	1.946	1.00
254_K	258_V	1.917	1.00
327_L	338_I	1.912	1.00
326_S	339_K	1.910	1.00
38_C	42_S	1.830	1.00
54_L	119_V	1.830	1.00
9_V	13_L	1.826	1.00
3_V	24_E	1.805	1.00
155_E	158_Q	1.781	1.00
8_D	196_R	1.780	1.00
295_V	320_Y	1.771	1.00
38_C	208_K	1.738	1.00
194_V	197_Q	1.722	1.00
191_T	194_V	1.712	1.00
60_P	127_N	1.701	1.00
9_V	12_K	1.691	1.00
298_V	312_G	1.687	1.00
102_S	105_E	1.684	1.00
293_N	317_N	1.681	1.00
153_K	205_I	1.679	1.00
255_D	258_V	1.648	1.00
57_K	131_E	1.636	1.00
37_M	306_Y	1.612	1.00
10_E	29_F	1.601	1.00
3_V	7_H	1.580	1.00
55_R	131_E	1.578	1.00
119_V	123_K	1.564	1.00
121_W	125_N	1.560	1.00
190_V	198_L	1.559	1.00
270_I	316_V	1.555	1.00
272_F	314_G	1.534	1.00
287_K	330_E	1.533	1.00
167_F	172_V	1.520	1.00
199_M	209_P	1.518	1.00
150_I	207_I	1.517	1.00
196_R	200_M	1.511	1.00
322_Y	325_Y	1.507	1.00
289_Y	294_E	1.498	1.00
329_G	338_I	1.492	1.00
13_L	209_P	1.487	1.00
54_L	110_T	1.484	1.00
120_N	124_S	1.474	1.00
57_K	129_D	1.457	1.00
45_F	140_I	1.440	1.00
45_F	203_V	1.432	1.00
84_A	244_V	1.432	1.00
169_G	201_D	1.424	1.00
36_H	217_S	1.421	1.00
275_R	278_E	1.416	1.00
138_G	192_L	1.415	1.00
101_V	105_E	1.413	1.00
59_N	127_N	1.398	1.00
220_Q	302_T	1.390	1.00
201_D	204_K	1.382	1.00
42_S	208_K	1.381	1.00
68_A	86_L	1.380	1.00
313_M	343_F	1.380	1.00
80_I	97_M	1.380	1.00
67_V	83_T	1.380	1.00
67_V	98_V	1.378	1.00
171_D	194_V	1.373	1.00
84_A	92_F	1.368	1.00
5_P	138_G	1.362	1.00
34_E	208_K	1.349	1.00
239_E	267_K	1.340	1.00
238_V	247_L	1.339	1.00
159_L	162_K	1.332	1.00
168_M	173_F	1.328	1.00
84_A	242_Y	1.322	1.00
108_I	122_I	1.310	1.00
289_Y	330_E	1.309	1.00
15_A	25_M	1.306	1.00
290_S	320_Y	1.305	1.00
250_D	255_D	1.294	1.00
87_N	233_E	1.288	1.00
55_R	133_L	1.286	1.00
288_I	329_G	1.283	1.00
317_N	320_Y	1.282	1.00
71_V	98_V	1.279	1.00
6_F	140_I	1.273	1.00
272_F	338_I	1.269	1.00
61_R	106_W	1.266	1.00
115_R	132_D	1.264	1.00
9_V	196_R	1.263	1.00
18_G	27_M	1.255	1.00
303_F	308_N	1.247	1.00
240_A	315_Y	1.242	1.00
56_V	108_I	1.236	1.00
275_R	337_D	1.234	1.00
64_E	72_N	1.225	1.00
149_E	152_G	1.225	1.00
131_E	136_K	1.225	1.00
238_V	257_L	1.213	1.00
66_L	125_N	1.209	1.00
7_H	24_E	1.190	1.00
235_I	315_Y	1.186	1.00
142_I	151_L	1.178	1.00
325_Y	340_I	1.178	1.00
126_S	130_V	1.174	1.00
238_V	265_I	1.172	1.00
255_D	259_E	1.157	1.00
33_A	37_M	1.154	1.00
197_Q	201_D	1.148	1.00
220_Q	300_S	1.144	1.00
43_V	207_I	1.135	1.00
117_K	233_E	1.133	1.00
100_K	106_W	1.133	1.00
232_D	235_I	1.124	1.00
119_V	130_V	1.123	1.00
125_N	252_I	1.118	1.00
100_K	103_E	1.113	1.00
76_S	102_S	1.108	1.00
273_K	341_D	1.108	1.00
239_E	260_R	1.100	1.00
261_I	264_G	1.099	1.00
292_G	335_Q	1.098	1.00
121_W	252_I	1.090	1.00
70_E	73_K	1.088	1.00
98_V	106_W	1.087	1.00
114_N	117_K	1.086	1.00
219_R	300_S	1.080	1.00
190_V	195_G	1.078	1.00
31_S	34_E	1.077	1.00
3_V	8_D	1.077	1.00
116_E	120_N	1.077	1.00
56_V	122_I	1.073	1.00
153_K	206_G	1.069	1.00
75_N	78_I	1.066	1.00
98_V	108_I	1.066	1.00
133_L	137_Y	1.063	1.00
7_H	17_F	1.051	1.00
65_M	252_I	1.045	1.00
247_L	261_I	1.041	1.00
290_S	295_V	1.038	1.00
148_E	184_N	1.037	1.00
289_Y	292_G	1.034	1.00
85_F	122_I	1.030	1.00
272_F	329_G	1.025	1.00
289_Y	328_T	1.023	1.00
37_M	308_N	1.023	1.00
76_S	103_E	1.023	1.00
331_I	336_Y	1.021	1.00
42_S	206_G	1.018	1.00
52_G	115_R	1.015	1.00
34_E	37_M	1.014	1.00
55_R	107_L	1.013	1.00
163_L	166_R	1.004	1.00
150_I	205_I	1.003	1.00
30_T	34_E	1.003	1.00
56_V	61_R	1.002	1.00
256_S	260_R	1.000	1.00
316_V	327_L	0.998	1.00
201_D	205_I	0.997	1.00
275_R	326_S	0.995	1.00
63_F	106_W	0.989	1.00
162_K	165_T	0.983	1.00
140_I	199_M	0.977	1.00
327_L	340_I	0.976	1.00
167_F	170_Y	0.974	1.00
274_M	338_I	0.970	1.00
290_S	328_T	0.969	1.00
320_Y	325_Y	0.968	1.00
225_V	231_I	0.967	1.00
92_F	231_I	0.965	1.00
69_K	83_T	0.962	1.00
323_L	342_E	0.959	1.00
260_R	265_I	0.958	1.00
295_V	327_L	0.958	1.00
165_T	172_V	0.955	1.00
6_F	195_G	0.953	1.00
200_M	204_K	0.939	1.00
324_G	339_K	0.937	1.00
38_C	206_G	0.934	1.00
321_F	325_Y	0.931	1.00
258_V	262_R	0.922	1.00
73_K	81_G	0.918	1.00
148_E	186_L	0.915	1.00
53_R	137_Y	0.914	1.00
142_I	150_I	0.913	1.00
143_Q	185_G	0.912	1.00
294_E	297_Y	0.909	1.00
101_V	174_L	0.906	1.00
48_L	141_A	0.905	1.00
236_T	239_E	0.900	1.00
247_L	251_F	0.900	1.00
190_V	194_V	0.897	1.00
5_P	192_L	0.896	1.00
69_K	246_S	0.892	1.00
171_D	197_Q	0.892	1.00
268_V	318_P	0.892	1.00
10_E	26_P	0.886	1.00
23_W	115_R	0.882	1.00
17_F	24_E	0.881	1.00
82_P	95_D	0.879	1.00
4_S	7_H	0.878	1.00
123_K	126_S	0.876	1.00
45_F	199_M	0.876	1.00
278_E	337_D	0.874	1.00
152_G	157_K	0.868	1.00
265_I	318_P	0.866	1.00
38_C	210_A	0.861	1.00
36_H	218_L	0.858	0.99
278_E	336_Y	0.851	0.99
59_N	104_N	0.851	0.99
133_L	136_K	0.851	0.99
304_S	311_I	0.848	0.99
87_N	93_K	0.848	0.99
92_F	240_A	0.846	0.99
28_S	32_Y	0.841	0.99
56_V	130_V	0.841	0.99
169_G	197_Q	0.833	0.99
57_K	104_N	0.833	0.99
45_F	142_I	0.830	0.99
93_K	117_K	0.825	0.99
139_M	189_W	0.825	0.99
151_L	156_L	0.820	0.99
316_V	321_F	0.819	0.99
13_L	200_M	0.819	0.99
67_V	85_F	0.818	0.99
169_G	173_F	0.818	0.99
88_D	252_I	0.818	0.99
63_F	71_V	0.816	0.99
121_W	124_S	0.816	0.99
266_D	318_P	0.815	0.99
175_I	186_L	0.814	0.99
65_M	250_D	0.807	0.99
85_F	96_V	0.805	0.99
247_L	258_V	0.803	0.99
282_P	286_S	0.803	0.99
67_V	71_V	0.795	0.99
251_F	258_V	0.790	0.99
177_R	184_N	0.790	0.99
138_G	190_V	0.788	0.99
239_E	266_D	0.787	0.99
83_T	98_V	0.781	0.99
66_L	121_W	0.779	0.99
210_A	214_A	0.778	0.99
171_D	198_L	0.777	0.99
247_L	254_K	0.772	0.99
155_E	160_E	0.770	0.99
68_A	84_A	0.768	0.99
13_L	29_F	0.758	0.99
68_A	245_F	0.758	0.99
110_T	118_I	0.756	0.99
238_V	245_F	0.755	0.99
137_Y	191_T	0.753	0.99
236_T	256_S	0.753	0.99
54_L	122_I	0.749	0.99
86_L	257_L	0.743	0.99
235_I	267_K	0.743	0.99
11_E	24_E	0.737	0.98
64_E	249_K	0.737	0.98
120_N	123_K	0.736	0.98
51_M	109_V	0.733	0.98
148_E	157_K	0.731	0.98
146_K	206_G	0.730	0.98
227_Y	231_I	0.729	0.98
99_Y	176_S	0.729	0.98
83_T	96_V	0.727	0.98
13_L	199_M	0.727	0.98
16_N	28_S	0.723	0.98
157_K	160_E	0.722	0.98
203_V	209_P	0.719	0.98
241_R	268_V	0.717	0.98
257_L	260_R	0.715	0.98
274_M	310_V	0.713	0.98
101_V	107_L	0.711	0.98
119_V	132_D	0.708	0.98
39_V	210_A	0.708	0.98
316_V	340_I	0.706	0.98
12_K	196_R	0.705	0.98
269_R	313_M	0.704	0.98
267_K	317_N	0.702	0.98
287_K	297_Y	0.701	0.98
147_L	184_N	0.699	0.98
160_E	163_L	0.699	0.98
175_I	188_V	0.698	0.98
188_V	202_L	0.698	0.98
324_G	340_I	0.696	0.98
53_R	189_W	0.694	0.98
203_V	207_I	0.693	0.98
197_Q	200_M	0.692	0.98
152_G	155_E	0.691	0.98
88_D	125_N	0.691	0.98
136_K	191_T	0.690	0.98
251_F	257_L	0.688	0.98
318_P	321_F	0.688	0.98
101_V	165_T	0.687	0.98
290_S	327_L	0.686	0.98
232_D	297_Y	0.684	0.97
40_R	221_E	0.682	0.97
13_L	203_V	0.682	0.97
268_V	321_F	0.681	0.97
36_H	306_Y	0.680	0.97
282_P	310_V	0.677	0.97
156_L	159_L	0.676	0.97
278_E	310_V	0.675	0.97
53_R	139_M	0.675	0.97
239_E	265_I	0.675	0.97
39_V	218_L	0.674	0.97
92_F	230_D	0.674	0.97
142_I	207_I	0.670	0.97
149_E	153_K	0.670	0.97
63_F	108_I	0.669	0.97
32_Y	213_I	0.669	0.97
15_A	27_M	0.667	0.97
151_L	186_L	0.663	0.97
282_P	338_I	0.660	0.97
69_K	81_G	0.660	0.97
157_K	162_K	0.659	0.97
283_R	286_S	0.656	0.97
272_F	327_L	0.655	0.97
168_M	171_D	0.655	0.97
9_V	199_M	0.654	0.97
282_P	329_G	0.651	0.97
50_H	212_L	0.647	0.96
142_I	188_V	0.647	0.96
68_A	244_V	0.646	0.96
67_V	81_G	0.645	0.96
9_V	203_V	0.644	0.96
270_I	321_F	0.644	0.96
303_F	310_V	0.643	0.96
45_F	207_I	0.642	0.96
259_E	262_R	0.641	0.96
159_L	163_L	0.639	0.96
140_I	195_G	0.638	0.96
173_F	188_V	0.637	0.96
55_R	101_V	0.637	0.96
217_S	302_T	0.627	0.96
230_D	269_R	0.626	0.96
63_F	122_I	0.625	0.96
93_K	233_E	0.625	0.96
70_E	246_S	0.623	0.96
323_L	343_F	0.623	0.96
290_S	325_Y	0.623	0.96
96_V	108_I	0.621	0.96
223_G	343_F	0.619	0.95
181_T	185_G	0.619	0.95
237_P	257_L	0.619	0.95
63_F	67_V	0.615	0.95
271_G	343_F	0.615	0.95
56_V	63_F	0.610	0.95
87_N	91_G	0.608	0.95
173_F	190_V	0.607	0.95
288_I	327_L	0.603	0.95
269_R	315_Y	0.603	0.95
40_R	218_L	0.602	0.95
66_L	252_I	0.602	0.95
278_E	282_P	0.602	0.95
169_G	172_V	0.602	0.95
134_T	137_Y	0.600	0.95
60_P	128_L	0.599	0.95
323_L	327_L	0.598	0.95
46_F	210_A	0.598	0.95
52_G	110_T	0.597	0.95
177_R	186_L	0.596	0.94
267_K	297_Y	0.596	0.94
62_E	65_M	0.596	0.94
143_Q	181_T	0.594	0.94
238_V	261_I	0.593	0.94
286_S	329_G	0.591	0.94
107_L	189_W	0.591	0.94
220_Q	311_I	0.590	0.94
62_E	72_N	0.590	0.94
211_G	214_A	0.590	0.94
107_L	137_Y	0.589	0.94
330_E	334_K	0.588	0.94
217_S	304_S	0.587	0.94
273_K	311_I	0.585	0.94
260_R	264_G	0.584	0.94
93_K	121_W	0.583	0.94
247_L	257_L	0.582	0.94
89_K	234_T	0.581	0.94
40_R	306_Y	0.580	0.94
48_L	139_M	0.580	0.94
258_V	261_I	0.580	0.94
256_S	259_E	0.579	0.94
85_F	118_I	0.577	0.93
118_I	121_W	0.576	0.93
331_I	334_K	0.576	0.93
66_L	85_F	0.575	0.93
150_I	153_K	0.575	0.93
111_N	216_D	0.573	0.93
74_A	78_I	0.571	0.93
15_A	18_G	0.570	0.93
117_K	120_N	0.570	0.93
109_V	187_E	0.569	0.93
115_R	135_F	0.569	0.93
3_V	11_E	0.569	0.93
159_L	164_N	0.569	0.93
10_E	17_F	0.565	0.93
161_F	224_F	0.565	0.93
42_S	207_I	0.565	0.93
33_A	305_P	0.561	0.93
301_S	310_V	0.561	0.93
74_A	81_G	0.560	0.92
132_D	135_F	0.559	0.92
89_K	233_E	0.559	0.92
180_W	226_L	0.558	0.92
221_E	304_S	0.558	0.92
19_E	24_E	0.557	0.92
46_F	143_Q	0.554	0.92
226_L	229_E	0.554	0.92
10_E	13_L	0.553	0.92
232_D	267_K	0.553	0.92
237_P	245_F	0.550	0.92
89_K	256_S	0.550	0.92
136_K	193_D	0.549	0.92
264_G	318_P	0.549	0.92
171_D	191_T	0.547	0.92
176_S	189_W	0.545	0.91
35_E	211_G	0.545	0.91
216_D	226_L	0.544	0.91
49_S	138_G	0.544	0.91
324_G	327_L	0.543	0.91
54_L	130_V	0.543	0.91
110_T	119_V	0.542	0.91
150_I	206_G	0.542	0.91
86_L	92_F	0.540	0.91
245_F	251_F	0.540	0.91
61_R	100_K	0.539	0.91
100_K	105_E	0.539	0.91
304_S	309_R	0.538	0.91
28_S	31_S	0.538	0.91
8_D	24_E	0.538	0.91
6_F	10_E	0.538	0.91
238_V	260_R	0.537	0.91
298_V	301_S	0.536	0.91
67_V	96_V	0.533	0.91
30_T	208_K	0.533	0.91
280_T	336_Y	0.532	0.90
231_I	240_A	0.531	0.90
50_H	112_A	0.528	0.90
225_V	230_D	0.528	0.90
99_Y	109_V	0.527	0.90
323_L	341_D	0.527	0.90
53_R	134_T	0.526	0.90
29_F	209_P	0.526	0.90
271_G	311_I	0.526	0.90
259_E	264_G	0.522	0.90
231_I	235_I	0.521	0.90
321_F	340_I	0.517	0.89
162_K	224_F	0.516	0.89
65_M	125_N	0.516	0.89
168_M	201_D	0.516	0.89
158_Q	164_N	0.515	0.89
82_P	178_S	0.513	0.89
160_E	164_N	0.512	0.89
43_V	146_K	0.512	0.89
117_K	121_W	0.511	0.89
147_L	150_I	0.511	0.89
295_V	317_N	0.510	0.89
85_F	121_W	0.510	0.89
227_Y	233_E	0.510	0.89
17_F	25_M	0.508	0.88
299_T	315_Y	0.508	0.88
328_T	336_Y	0.508	0.88
82_P	244_V	0.507	0.88
184_N	222_M	0.507	0.88
111_N	226_L	0.505	0.88
249_K	254_K	0.505	0.88
273_K	307_L	0.505	0.88
42_S	150_I	0.503	0.88
309_R	339_K	0.503	0.88
230_D	235_I	0.502	0.88
16_N	27_M	0.502	0.88
154_N	157_K	0.502	0.88
223_G	271_G	0.502	0.88
225_V	243_W	0.500	0.88
36_H	305_P	0.500	0.88
45_F	202_L	0.500	0.88

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2gagA	1	0.9942	100	0.139	Contact Map
1yx2A	1	0.9913	100	0.14	Contact Map
1wosA	1	0.9855	100	0.143	Contact Map
1v5vA	2	0.9913	100	0.146	Contact Map
3girA	1	0.9798	100	0.157	Contact Map
1wsrA	2	0.9827	100	0.163	Contact Map
4pabA	1	0.9827	100	0.165	Contact Map
1pj5A	3	0.9798	100	0.166	Contact Map
1vloA	1	0.9624	100	0.17	Contact Map
3tfiA	2	0.9798	100	0.177	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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