GREMLIN Database
Q97ZI7 - Aminomethyltransferase
UniProt: Q97ZI7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 346 (338)
Sequences: 7141 (4693)
Seq/√Len: 255.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
9_V200_M3.7361.00
146_K149_E3.6851.00
273_K309_R3.3041.00
287_K294_E3.2851.00
43_V150_I3.1361.00
236_T260_R3.0841.00
55_R105_E3.0321.00
328_T335_Q2.7971.00
259_E263_S2.7191.00
7_H11_E2.6811.00
11_E17_F2.5321.00
288_I314_G2.5041.00
37_M41_N2.4881.00
138_G195_G2.4871.00
272_F312_G2.4791.00
42_S146_K2.4731.00
326_S337_D2.3271.00
57_K105_E2.2151.00
44_A210_A2.1741.00
275_R339_K2.1581.00
330_E335_Q2.1501.00
39_V44_A2.1321.00
64_E70_E2.1071.00
12_K200_M2.0891.00
66_L122_I2.0751.00
273_K339_K2.0711.00
285_Q297_Y2.0601.00
330_E333_G2.0261.00
304_S307_L2.0091.00
289_Y335_Q2.0031.00
290_S293_N2.0011.00
229_E284_H2.0001.00
76_S100_K1.9921.00
8_D12_K1.9871.00
328_T337_D1.9781.00
8_D11_E1.9611.00
250_D254_K1.9461.00
254_K258_V1.9171.00
327_L338_I1.9121.00
326_S339_K1.9101.00
38_C42_S1.8301.00
54_L119_V1.8301.00
9_V13_L1.8261.00
3_V24_E1.8051.00
155_E158_Q1.7811.00
8_D196_R1.7801.00
295_V320_Y1.7711.00
38_C208_K1.7381.00
194_V197_Q1.7221.00
191_T194_V1.7121.00
60_P127_N1.7011.00
9_V12_K1.6911.00
298_V312_G1.6871.00
102_S105_E1.6841.00
293_N317_N1.6811.00
153_K205_I1.6791.00
255_D258_V1.6481.00
57_K131_E1.6361.00
37_M306_Y1.6121.00
10_E29_F1.6011.00
3_V7_H1.5801.00
55_R131_E1.5781.00
119_V123_K1.5641.00
121_W125_N1.5601.00
190_V198_L1.5591.00
270_I316_V1.5551.00
272_F314_G1.5341.00
287_K330_E1.5331.00
167_F172_V1.5201.00
199_M209_P1.5181.00
150_I207_I1.5171.00
196_R200_M1.5111.00
322_Y325_Y1.5071.00
289_Y294_E1.4981.00
329_G338_I1.4921.00
13_L209_P1.4871.00
54_L110_T1.4841.00
120_N124_S1.4741.00
57_K129_D1.4571.00
45_F140_I1.4401.00
45_F203_V1.4321.00
84_A244_V1.4321.00
169_G201_D1.4241.00
36_H217_S1.4211.00
275_R278_E1.4161.00
138_G192_L1.4151.00
101_V105_E1.4131.00
59_N127_N1.3981.00
220_Q302_T1.3901.00
201_D204_K1.3821.00
42_S208_K1.3811.00
68_A86_L1.3801.00
313_M343_F1.3801.00
80_I97_M1.3801.00
67_V83_T1.3801.00
67_V98_V1.3781.00
171_D194_V1.3731.00
84_A92_F1.3681.00
5_P138_G1.3621.00
34_E208_K1.3491.00
239_E267_K1.3401.00
238_V247_L1.3391.00
159_L162_K1.3321.00
168_M173_F1.3281.00
84_A242_Y1.3221.00
108_I122_I1.3101.00
289_Y330_E1.3091.00
15_A25_M1.3061.00
290_S320_Y1.3051.00
250_D255_D1.2941.00
87_N233_E1.2881.00
55_R133_L1.2861.00
288_I329_G1.2831.00
317_N320_Y1.2821.00
71_V98_V1.2791.00
6_F140_I1.2731.00
272_F338_I1.2691.00
61_R106_W1.2661.00
115_R132_D1.2641.00
9_V196_R1.2631.00
18_G27_M1.2551.00
303_F308_N1.2471.00
240_A315_Y1.2421.00
56_V108_I1.2361.00
275_R337_D1.2341.00
64_E72_N1.2251.00
149_E152_G1.2251.00
131_E136_K1.2251.00
238_V257_L1.2131.00
66_L125_N1.2091.00
7_H24_E1.1901.00
235_I315_Y1.1861.00
142_I151_L1.1781.00
325_Y340_I1.1781.00
126_S130_V1.1741.00
238_V265_I1.1721.00
255_D259_E1.1571.00
33_A37_M1.1541.00
197_Q201_D1.1481.00
220_Q300_S1.1441.00
43_V207_I1.1351.00
117_K233_E1.1331.00
100_K106_W1.1331.00
232_D235_I1.1241.00
119_V130_V1.1231.00
125_N252_I1.1181.00
100_K103_E1.1131.00
76_S102_S1.1081.00
273_K341_D1.1081.00
239_E260_R1.1001.00
261_I264_G1.0991.00
292_G335_Q1.0981.00
121_W252_I1.0901.00
70_E73_K1.0881.00
98_V106_W1.0871.00
114_N117_K1.0861.00
219_R300_S1.0801.00
190_V195_G1.0781.00
31_S34_E1.0771.00
3_V8_D1.0771.00
116_E120_N1.0771.00
56_V122_I1.0731.00
153_K206_G1.0691.00
75_N78_I1.0661.00
98_V108_I1.0661.00
133_L137_Y1.0631.00
7_H17_F1.0511.00
65_M252_I1.0451.00
247_L261_I1.0411.00
290_S295_V1.0381.00
148_E184_N1.0371.00
289_Y292_G1.0341.00
85_F122_I1.0301.00
272_F329_G1.0251.00
289_Y328_T1.0231.00
37_M308_N1.0231.00
76_S103_E1.0231.00
331_I336_Y1.0211.00
42_S206_G1.0181.00
52_G115_R1.0151.00
34_E37_M1.0141.00
55_R107_L1.0131.00
163_L166_R1.0041.00
150_I205_I1.0031.00
30_T34_E1.0031.00
56_V61_R1.0021.00
256_S260_R1.0001.00
316_V327_L0.9981.00
201_D205_I0.9971.00
275_R326_S0.9951.00
63_F106_W0.9891.00
162_K165_T0.9831.00
140_I199_M0.9771.00
327_L340_I0.9761.00
167_F170_Y0.9741.00
274_M338_I0.9701.00
290_S328_T0.9691.00
320_Y325_Y0.9681.00
225_V231_I0.9671.00
92_F231_I0.9651.00
69_K83_T0.9621.00
323_L342_E0.9591.00
260_R265_I0.9581.00
295_V327_L0.9581.00
165_T172_V0.9551.00
6_F195_G0.9531.00
200_M204_K0.9391.00
324_G339_K0.9371.00
38_C206_G0.9341.00
321_F325_Y0.9311.00
258_V262_R0.9221.00
73_K81_G0.9181.00
148_E186_L0.9151.00
53_R137_Y0.9141.00
142_I150_I0.9131.00
143_Q185_G0.9121.00
294_E297_Y0.9091.00
101_V174_L0.9061.00
48_L141_A0.9051.00
236_T239_E0.9001.00
247_L251_F0.9001.00
190_V194_V0.8971.00
5_P192_L0.8961.00
69_K246_S0.8921.00
171_D197_Q0.8921.00
268_V318_P0.8921.00
10_E26_P0.8861.00
23_W115_R0.8821.00
17_F24_E0.8811.00
82_P95_D0.8791.00
4_S7_H0.8781.00
123_K126_S0.8761.00
45_F199_M0.8761.00
278_E337_D0.8741.00
152_G157_K0.8681.00
265_I318_P0.8661.00
38_C210_A0.8611.00
36_H218_L0.8580.99
278_E336_Y0.8510.99
59_N104_N0.8510.99
133_L136_K0.8510.99
304_S311_I0.8480.99
87_N93_K0.8480.99
92_F240_A0.8460.99
28_S32_Y0.8410.99
56_V130_V0.8410.99
169_G197_Q0.8330.99
57_K104_N0.8330.99
45_F142_I0.8300.99
93_K117_K0.8250.99
139_M189_W0.8250.99
151_L156_L0.8200.99
316_V321_F0.8190.99
13_L200_M0.8190.99
67_V85_F0.8180.99
169_G173_F0.8180.99
88_D252_I0.8180.99
63_F71_V0.8160.99
121_W124_S0.8160.99
266_D318_P0.8150.99
175_I186_L0.8140.99
65_M250_D0.8070.99
85_F96_V0.8050.99
247_L258_V0.8030.99
282_P286_S0.8030.99
67_V71_V0.7950.99
251_F258_V0.7900.99
177_R184_N0.7900.99
138_G190_V0.7880.99
239_E266_D0.7870.99
83_T98_V0.7810.99
66_L121_W0.7790.99
210_A214_A0.7780.99
171_D198_L0.7770.99
247_L254_K0.7720.99
155_E160_E0.7700.99
68_A84_A0.7680.99
13_L29_F0.7580.99
68_A245_F0.7580.99
110_T118_I0.7560.99
238_V245_F0.7550.99
137_Y191_T0.7530.99
236_T256_S0.7530.99
54_L122_I0.7490.99
86_L257_L0.7430.99
235_I267_K0.7430.99
11_E24_E0.7370.98
64_E249_K0.7370.98
120_N123_K0.7360.98
51_M109_V0.7330.98
148_E157_K0.7310.98
146_K206_G0.7300.98
227_Y231_I0.7290.98
99_Y176_S0.7290.98
83_T96_V0.7270.98
13_L199_M0.7270.98
16_N28_S0.7230.98
157_K160_E0.7220.98
203_V209_P0.7190.98
241_R268_V0.7170.98
257_L260_R0.7150.98
274_M310_V0.7130.98
101_V107_L0.7110.98
119_V132_D0.7080.98
39_V210_A0.7080.98
316_V340_I0.7060.98
12_K196_R0.7050.98
269_R313_M0.7040.98
267_K317_N0.7020.98
287_K297_Y0.7010.98
147_L184_N0.6990.98
160_E163_L0.6990.98
175_I188_V0.6980.98
188_V202_L0.6980.98
324_G340_I0.6960.98
53_R189_W0.6940.98
203_V207_I0.6930.98
197_Q200_M0.6920.98
152_G155_E0.6910.98
88_D125_N0.6910.98
136_K191_T0.6900.98
251_F257_L0.6880.98
318_P321_F0.6880.98
101_V165_T0.6870.98
290_S327_L0.6860.98
232_D297_Y0.6840.97
40_R221_E0.6820.97
13_L203_V0.6820.97
268_V321_F0.6810.97
36_H306_Y0.6800.97
282_P310_V0.6770.97
156_L159_L0.6760.97
278_E310_V0.6750.97
53_R139_M0.6750.97
239_E265_I0.6750.97
39_V218_L0.6740.97
92_F230_D0.6740.97
142_I207_I0.6700.97
149_E153_K0.6700.97
63_F108_I0.6690.97
32_Y213_I0.6690.97
15_A27_M0.6670.97
151_L186_L0.6630.97
282_P338_I0.6600.97
69_K81_G0.6600.97
157_K162_K0.6590.97
283_R286_S0.6560.97
272_F327_L0.6550.97
168_M171_D0.6550.97
9_V199_M0.6540.97
282_P329_G0.6510.97
50_H212_L0.6470.96
142_I188_V0.6470.96
68_A244_V0.6460.96
67_V81_G0.6450.96
9_V203_V0.6440.96
270_I321_F0.6440.96
303_F310_V0.6430.96
45_F207_I0.6420.96
259_E262_R0.6410.96
159_L163_L0.6390.96
140_I195_G0.6380.96
173_F188_V0.6370.96
55_R101_V0.6370.96
217_S302_T0.6270.96
230_D269_R0.6260.96
63_F122_I0.6250.96
93_K233_E0.6250.96
70_E246_S0.6230.96
323_L343_F0.6230.96
290_S325_Y0.6230.96
96_V108_I0.6210.96
223_G343_F0.6190.95
181_T185_G0.6190.95
237_P257_L0.6190.95
63_F67_V0.6150.95
271_G343_F0.6150.95
56_V63_F0.6100.95
87_N91_G0.6080.95
173_F190_V0.6070.95
288_I327_L0.6030.95
269_R315_Y0.6030.95
40_R218_L0.6020.95
66_L252_I0.6020.95
278_E282_P0.6020.95
169_G172_V0.6020.95
134_T137_Y0.6000.95
60_P128_L0.5990.95
323_L327_L0.5980.95
46_F210_A0.5980.95
52_G110_T0.5970.95
177_R186_L0.5960.94
267_K297_Y0.5960.94
62_E65_M0.5960.94
143_Q181_T0.5940.94
238_V261_I0.5930.94
286_S329_G0.5910.94
107_L189_W0.5910.94
220_Q311_I0.5900.94
62_E72_N0.5900.94
211_G214_A0.5900.94
107_L137_Y0.5890.94
330_E334_K0.5880.94
217_S304_S0.5870.94
273_K311_I0.5850.94
260_R264_G0.5840.94
93_K121_W0.5830.94
247_L257_L0.5820.94
89_K234_T0.5810.94
40_R306_Y0.5800.94
48_L139_M0.5800.94
258_V261_I0.5800.94
256_S259_E0.5790.94
85_F118_I0.5770.93
118_I121_W0.5760.93
331_I334_K0.5760.93
66_L85_F0.5750.93
150_I153_K0.5750.93
111_N216_D0.5730.93
74_A78_I0.5710.93
15_A18_G0.5700.93
117_K120_N0.5700.93
109_V187_E0.5690.93
115_R135_F0.5690.93
3_V11_E0.5690.93
159_L164_N0.5690.93
10_E17_F0.5650.93
161_F224_F0.5650.93
42_S207_I0.5650.93
33_A305_P0.5610.93
301_S310_V0.5610.93
74_A81_G0.5600.92
132_D135_F0.5590.92
89_K233_E0.5590.92
180_W226_L0.5580.92
221_E304_S0.5580.92
19_E24_E0.5570.92
46_F143_Q0.5540.92
226_L229_E0.5540.92
10_E13_L0.5530.92
232_D267_K0.5530.92
237_P245_F0.5500.92
89_K256_S0.5500.92
136_K193_D0.5490.92
264_G318_P0.5490.92
171_D191_T0.5470.92
176_S189_W0.5450.91
35_E211_G0.5450.91
216_D226_L0.5440.91
49_S138_G0.5440.91
324_G327_L0.5430.91
54_L130_V0.5430.91
110_T119_V0.5420.91
150_I206_G0.5420.91
86_L92_F0.5400.91
245_F251_F0.5400.91
61_R100_K0.5390.91
100_K105_E0.5390.91
304_S309_R0.5380.91
28_S31_S0.5380.91
8_D24_E0.5380.91
6_F10_E0.5380.91
238_V260_R0.5370.91
298_V301_S0.5360.91
67_V96_V0.5330.91
30_T208_K0.5330.91
280_T336_Y0.5320.90
231_I240_A0.5310.90
50_H112_A0.5280.90
225_V230_D0.5280.90
99_Y109_V0.5270.90
323_L341_D0.5270.90
53_R134_T0.5260.90
29_F209_P0.5260.90
271_G311_I0.5260.90
259_E264_G0.5220.90
231_I235_I0.5210.90
321_F340_I0.5170.89
162_K224_F0.5160.89
65_M125_N0.5160.89
168_M201_D0.5160.89
158_Q164_N0.5150.89
82_P178_S0.5130.89
160_E164_N0.5120.89
43_V146_K0.5120.89
117_K121_W0.5110.89
147_L150_I0.5110.89
295_V317_N0.5100.89
85_F121_W0.5100.89
227_Y233_E0.5100.89
17_F25_M0.5080.88
299_T315_Y0.5080.88
328_T336_Y0.5080.88
82_P244_V0.5070.88
184_N222_M0.5070.88
111_N226_L0.5050.88
249_K254_K0.5050.88
273_K307_L0.5050.88
42_S150_I0.5030.88
309_R339_K0.5030.88
230_D235_I0.5020.88
16_N27_M0.5020.88
154_N157_K0.5020.88
223_G271_G0.5020.88
225_V243_W0.5000.88
36_H305_P0.5000.88
45_F202_L0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gagA 1 0.9942 100 0.139 Contact Map
1yx2A 1 0.9913 100 0.14 Contact Map
1wosA 1 0.9855 100 0.143 Contact Map
1v5vA 2 0.9913 100 0.146 Contact Map
3girA 1 0.9798 100 0.157 Contact Map
1wsrA 2 0.9827 100 0.163 Contact Map
4pabA 1 0.9827 100 0.165 Contact Map
1pj5A 3 0.9798 100 0.166 Contact Map
1vloA 1 0.9624 100 0.17 Contact Map
3tfiA 2 0.9798 100 0.177 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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