GREMLIN Database
GCSH1 - Probable glycine cleavage system H protein 1
UniProt: Q97ZI6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 137 (124)
Sequences: 3768 (2387)
Seq/√Len: 214.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
126_S129_K4.1811.00
102_D105_G3.4741.00
84_I113_K3.4201.00
65_V110_F3.0891.00
33_V111_K2.8781.00
87_E111_K2.6951.00
102_D106_E2.2801.00
38_D41_Q2.1261.00
32_A114_A2.0401.00
26_L32_A1.9451.00
58_E115_S1.9351.00
31_V111_K1.9311.00
58_E84_I1.8981.00
116_K119_E1.8701.00
125_L133_K1.8441.00
127_P131_I1.8241.00
59_V79_S1.8081.00
82_S119_E1.8071.00
118_S122_E1.7711.00
25_V33_V1.7541.00
95_H98_I1.7261.00
15_R25_V1.7201.00
61_A123_K1.5981.00
15_R104_Y1.5651.00
99_I109_I1.5401.00
81_L114_A1.5311.00
14_D25_V1.5251.00
30_N113_K1.5221.00
60_K63_E1.4941.00
66_G77_I1.4821.00
67_V74_A1.4751.00
38_D42_K1.4441.00
54_Q57_K1.4401.00
91_K95_H1.3981.00
31_V113_K1.3771.00
98_I107_G1.3721.00
19_E133_K1.3661.00
64_S76_D1.3501.00
60_K82_S1.3071.00
56_Q84_I1.2841.00
24_V32_A1.2771.00
92_L109_I1.2641.00
41_Q100_N1.2581.00
65_V77_I1.2441.00
91_K106_E1.2421.00
52_L88_V1.2351.00
67_V71_V1.1841.00
39_Y43_K1.1501.00
91_K98_I1.1471.00
59_V65_V1.1111.00
31_V86_V1.1041.00
95_H101_K1.0941.00
26_L114_A1.0941.00
83_G112_L1.0861.00
13_T128_E1.0821.00
22_E71_V1.0791.00
86_V113_K1.0761.00
90_N93_L1.0721.00
51_E67_V1.0611.00
129_K132_E1.0601.00
27_S33_V1.0571.00
34_I110_F1.0451.00
55_L88_V1.0111.00
48_V71_V0.9951.00
50_I92_L0.9771.00
128_E131_I0.9611.00
16_L122_E0.9551.00
114_A117_L0.9471.00
61_A119_E0.9370.99
18_T24_V0.9340.99
87_E90_N0.9330.99
57_K63_E0.9300.99
81_L112_L0.9190.99
52_L109_I0.9140.99
16_L121_K0.9040.99
98_I101_K0.9020.99
24_V81_L0.8990.99
11_V131_I0.8690.99
36_I68_I0.8690.99
11_V127_P0.8660.99
26_L121_K0.8640.99
18_T22_E0.8620.99
18_T37_T0.8540.99
91_K94_E0.8460.99
82_S115_S0.8300.99
50_I68_I0.8270.99
48_V74_A0.8220.99
27_S31_V0.8210.99
32_A81_L0.8160.99
13_T131_I0.8160.99
77_I110_F0.8130.99
98_I106_E0.8090.98
79_S112_L0.8020.98
27_S111_K0.7940.98
20_T78_F0.7850.98
69_E72_K0.7790.98
23_W35_G0.7770.98
11_V134_I0.7750.98
17_Y104_Y0.7740.98
92_L98_I0.7690.98
38_D104_Y0.7610.98
27_S30_N0.7580.98
67_V76_D0.7580.98
16_L126_S0.7550.98
97_E101_K0.7520.98
34_I112_L0.7510.98
104_Y127_P0.7410.97
26_L30_N0.7380.97
30_N114_A0.7350.97
46_D97_E0.7280.97
44_L75_A0.7270.97
20_T73_A0.7130.97
125_L129_K0.7080.96
47_I68_I0.7080.96
21_D45_R0.7020.96
55_L87_E0.6970.96
11_V104_Y0.6780.96
41_Q104_Y0.6780.96
77_I109_I0.6690.95
26_L117_L0.6580.95
90_N94_E0.6560.95
59_V85_I0.6550.95
72_K75_A0.6550.95
12_L127_P0.6460.94
53_P85_I0.6440.94
53_P88_V0.6430.94
31_V87_E0.6390.94
59_V82_S0.6330.94
20_T62_G0.6310.93
70_S73_A0.6310.93
117_L121_K0.6280.93
16_L26_L0.6230.93
43_K70_S0.6120.92
55_L90_N0.6100.92
17_Y37_T0.6090.92
48_V69_E0.6080.92
47_I66_G0.6060.92
19_E129_K0.6040.92
128_E132_E0.6020.92
12_L37_T0.5970.91
115_S119_E0.5940.91
40_A75_A0.5940.91
101_K106_E0.5890.91
28_N31_V0.5890.91
12_L17_Y0.5860.91
31_V114_A0.5810.90
49_G75_A0.5720.90
22_E48_V0.5700.90
54_Q94_E0.5690.89
50_I96_P0.5690.89
102_D107_G0.5650.89
60_K122_E0.5640.89
44_L73_A0.5630.89
22_E78_F0.5610.89
53_P70_S0.5610.89
56_Q86_V0.5600.89
43_K75_A0.5590.89
37_T103_P0.5570.88
22_E73_A0.5530.88
29_D113_K0.5510.88
34_I80_P0.5500.88
64_S93_L0.5470.88
66_G110_F0.5450.87
47_I67_V0.5450.87
19_E123_K0.5390.87
32_A121_K0.5380.87
25_V28_N0.5330.86
49_G69_E0.5310.86
38_D100_N0.5300.86
30_N33_V0.5300.86
49_G72_K0.5290.86
85_I110_F0.5240.85
14_D127_P0.5230.85
118_S121_K0.5200.85
64_S73_A0.5190.85
33_V107_G0.5180.85
30_N117_L0.5110.84
70_S74_A0.5100.84
18_T124_L0.5080.83
16_L46_D0.5070.83
36_I40_A0.5070.83
47_I100_N0.5060.83
22_E40_A0.5040.83
88_V93_L0.5020.83
64_S67_V0.5010.83
117_L122_E0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hgbA 1 0.9343 100 0.164 Contact Map
3mxuA 3 0.9635 100 0.196 Contact Map
3tzuA 2 0.8832 100 0.237 Contact Map
3a7lA 1 0.9343 100 0.245 Contact Map
1hpcA 2 0.927 100 0.245 Contact Map
3wdnA 1 0.8978 100 0.272 Contact Map
1onlA 1 0.9197 100 0.293 Contact Map
1zkoA 2 0.927 100 0.305 Contact Map
5a35A 1 0.8175 100 0.342 Contact Map
1gjxA 1 0.5912 96.6 0.85 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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