GREMLIN Database
Q97ZI5 - Uncharacterized protein
UniProt: Q97ZI5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 251 (222)
Sequences: 1277 (906)
Seq/√Len: 60.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_S30_D4.7691.00
195_E225_R4.4901.00
24_L113_I3.8871.00
24_L108_A3.7781.00
106_S176_K3.6881.00
59_H96_S3.2571.00
35_G121_G2.9551.00
100_L165_P2.6551.00
96_S99_H2.5821.00
37_I197_A2.5661.00
225_R229_K2.5021.00
74_P80_Y2.4741.00
50_E76_R2.4301.00
119_I200_A2.4141.00
84_L111_Y2.3301.00
74_P78_Y2.1991.00
141_S179_R2.1551.00
172_Q175_K2.1431.00
73_S80_Y2.1311.00
136_Y186_E2.1051.00
185_V200_A2.0901.00
173_S180_N2.0751.00
219_K222_E2.0631.00
109_E176_K2.0541.00
52_G107_Y2.0241.00
106_S110_K2.0001.00
24_L86_L1.9881.00
34_V200_A1.9821.00
41_F45_Y1.9601.00
108_A178_I1.8861.00
137_W153_L1.8421.00
115_T179_R1.7840.99
202_D211_K1.7780.99
77_L86_L1.7750.99
198_A218_L1.7650.99
25_L30_D1.7510.99
24_L30_D1.7160.99
133_P199_V1.6660.99
105_V176_K1.6500.99
116_I173_S1.5390.98
140_S180_N1.5270.98
135_P203_I1.5170.98
84_L113_I1.5130.98
76_R80_Y1.5100.98
39_G85_L1.5080.98
133_P185_V1.5040.98
51_Y84_L1.4700.98
242_Y245_L1.4690.98
200_A204_L1.4560.98
38_S119_I1.4520.98
21_P82_N1.4480.98
232_M235_T1.4340.98
108_A113_I1.4270.97
48_L80_Y1.3870.97
39_G137_W1.3730.97
42_L85_L1.3570.97
202_D218_L1.3530.97
198_A221_A1.3490.96
105_V173_S1.3120.96
20_R114_Q1.3030.96
51_Y79_H1.3030.96
243_S247_P1.2900.95
197_A201_L1.2860.95
18_I82_N1.2650.95
139_A145_A1.2610.95
214_T218_L1.2400.94
45_Y216_S1.2400.94
223_E227_R1.2280.94
86_L104_V1.2180.94
46_L83_F1.2180.94
62_P194_P1.2170.94
127_R188_F1.2100.94
48_L85_L1.2050.93
183_I204_L1.2040.93
115_T147_E1.1860.93
117_I181_L1.1850.93
25_L210_F1.1850.93
118_S180_N1.1840.93
163_S167_A1.1830.93
28_L165_P1.1780.93
127_R131_E1.1720.92
191_L232_M1.1620.92
49_R204_L1.1620.92
61_P193_D1.1490.92
21_P111_Y1.1460.92
90_I188_F1.1410.91
148_L153_L1.1390.91
18_I21_P1.1240.91
215_S218_L1.1230.91
78_Y87_H1.1210.91
45_Y213_D1.1070.90
26_V118_S1.0960.90
27_S35_G1.0840.89
23_Y26_V1.0820.89
66_V71_A1.0810.89
25_L28_L1.0770.89
86_L100_L1.0750.89
120_T184_V1.0720.89
58_K99_H1.0690.88
73_S78_Y1.0680.88
231_L235_T1.0630.88
202_D214_T1.0550.88
148_L181_L1.0540.88
85_L135_P1.0500.88
171_F175_K1.0490.87
18_I79_H1.0470.87
115_T181_L1.0470.87
64_S171_F1.0440.87
68_N71_A1.0360.87
183_I207_M1.0190.86
205_S211_K1.0170.86
27_S39_G1.0150.86
219_K223_E1.0070.85
221_A225_R1.0060.85
138_V170_L0.9950.85
97_I127_R0.9940.84
187_S196_A0.9820.84
195_E221_A0.9800.84
238_E241_N0.9760.83
105_V109_E0.9740.83
121_G208_L0.9700.83
220_E223_E0.9690.83
226_E230_G0.9630.83
117_I207_M0.9620.83
56_S166_Y0.9620.83
38_S217_L0.9600.82
229_K233_Q0.9530.82
26_V30_D0.9430.81
43_I78_Y0.9340.81
139_A202_D0.9230.80
48_L83_F0.9170.79
90_I127_R0.9170.79
215_S219_K0.9150.79
24_L116_I0.9130.79
90_I97_I0.9090.79
98_N172_Q0.9040.78
50_E53_E0.9030.78
23_Y208_L0.8970.78
55_Y59_H0.8930.78
205_S208_L0.8920.77
192_P220_E0.8910.77
227_R231_L0.8910.77
86_L113_I0.8900.77
35_G193_D0.8760.76
206_K215_S0.8710.76
236_R239_L0.8680.76
77_L158_V0.8600.75
115_T144_F0.8600.75
50_E78_Y0.8520.74
76_R232_M0.8510.74
198_A220_E0.8500.74
188_F228_I0.8480.74
148_L183_I0.8450.74
60_L103_L0.8330.72
134_T186_E0.8290.72
133_P186_E0.8160.71
116_I178_I0.8130.71
230_G233_Q0.8110.70
146_K230_G0.8110.70
97_I163_S0.8090.70
172_Q176_K0.7990.69
46_L213_D0.7970.69
129_D188_F0.7870.68
194_P220_E0.7860.68
66_V228_I0.7860.68
54_I193_D0.7840.68
97_I188_F0.7830.68
97_I190_D0.7830.68
142_E145_A0.7820.68
80_Y83_F0.7820.68
230_G234_Q0.7740.67
201_L205_S0.7700.66
25_L117_I0.7660.66
201_L213_D0.7650.66
164_G168_P0.7640.66
45_Y212_V0.7610.66
130_L188_F0.7590.65
105_V164_G0.7590.65
108_A173_S0.7580.65
220_E227_R0.7560.65
34_V196_A0.7550.65
60_L231_L0.7440.64
135_P200_A0.7380.63
237_Q240_P0.7370.63
51_Y54_I0.7370.63
109_E178_I0.7230.62
51_Y240_P0.7210.61
121_G155_K0.7140.61
30_D120_T0.7130.60
101_A239_L0.7080.60
31_A162_V0.7070.60
47_N236_R0.7050.60
90_I129_D0.7040.59
143_D202_D0.6990.59
223_E226_E0.6980.59
34_V148_L0.6970.59
238_E242_Y0.6960.59
30_D194_P0.6950.59
199_V203_I0.6900.58
59_H221_A0.6880.58
169_I185_V0.6880.58
112_G178_I0.6860.58
120_T161_Y0.6830.57
74_P90_I0.6820.57
74_P79_H0.6820.57
100_L104_V0.6720.56
26_V166_Y0.6720.56
48_L78_Y0.6710.56
75_I86_L0.6660.55
109_E177_L0.6600.55
106_S233_Q0.6580.54
242_Y246_R0.6560.54
25_L233_Q0.6560.54
91_A127_R0.6510.54
95_N111_Y0.6510.54
35_G167_A0.6500.53
43_I85_L0.6490.53
129_D190_D0.6450.53
24_L28_L0.6420.53
91_A97_I0.6410.52
177_L221_A0.6360.52
60_L75_I0.6330.52
32_G193_D0.6310.51
38_S198_A0.6280.51
35_G120_T0.6270.51
33_L160_G0.6270.51
107_Y237_Q0.6260.51
59_H99_H0.6240.51
216_S220_E0.6220.50
99_H103_L0.6210.50
91_A173_S0.6200.50
139_A144_F0.6190.50
105_V243_S0.6180.50
125_P189_L0.6170.50
97_I131_E0.6140.49
26_V29_P0.6140.49
82_N146_K0.6140.49
127_R190_D0.6130.49
67_V72_K0.6130.49
42_L78_Y0.6120.49
26_V169_I0.6120.49
32_G121_G0.6070.49
90_I190_D0.6060.49
119_I212_V0.6050.48
126_N231_L0.6030.48
70_V116_I0.6020.48
33_L101_A0.6000.48
106_S109_E0.6000.48
67_V158_V0.5990.48
160_G193_D0.5970.48
72_K243_S0.5940.47
88_S190_D0.5890.47
88_S97_I0.5880.46
31_A91_A0.5860.46
47_N142_E0.5850.46
120_T163_S0.5850.46
164_G167_A0.5840.46
76_R172_Q0.5830.46
49_R237_Q0.5820.46
201_L233_Q0.5810.46
216_S221_A0.5810.46
51_Y104_V0.5790.45
37_I41_F0.5730.45
209_G238_E0.5710.45
31_A97_I0.5700.44
40_E87_H0.5700.44
43_I87_H0.5700.44
157_F185_V0.5660.44
49_R135_P0.5650.44
114_Q229_K0.5650.44
192_P224_I0.5640.44
99_H135_P0.5630.44
119_I125_P0.5630.44
156_K169_I0.5630.44
42_L205_S0.5620.44
167_A186_E0.5600.43
31_A34_V0.5590.43
19_G32_G0.5570.43
28_L36_S0.5570.43
24_L27_S0.5560.43
28_L86_L0.5550.43
60_L77_L0.5540.43
107_Y111_Y0.5530.43
94_A126_N0.5530.43
64_S71_A0.5530.43
38_S201_L0.5530.43
73_S184_V0.5520.42
123_P161_Y0.5520.42
189_L245_L0.5500.42
31_A182_L0.5500.42
31_A188_F0.5490.42
196_A237_Q0.5480.42
68_N244_G0.5480.42
53_E76_R0.5470.42
75_I88_S0.5460.42
111_Y114_Q0.5460.42
103_L108_A0.5460.42
80_Y85_L0.5450.42
192_P232_M0.5440.42
19_G23_Y0.5400.41
239_L243_S0.5390.41
35_G61_P0.5370.41
31_A62_P0.5360.41
58_K94_A0.5360.41
161_Y184_V0.5340.41
25_L39_G0.5320.40
25_L225_R0.5290.40
139_A244_G0.5290.40
127_R130_L0.5280.40
25_L215_S0.5280.40
17_Q174_A0.5280.40
38_S68_N0.5230.39
179_R224_I0.5200.39
52_G76_R0.5190.39
37_I180_N0.5190.39
227_R230_G0.5190.39
209_G213_D0.5130.38
76_R169_I0.5130.38
62_P131_E0.5130.38
168_P219_K0.5130.38
111_Y207_M0.5120.38
182_L208_L0.5110.38
55_Y91_A0.5100.38
106_S243_S0.5080.38
140_S183_I0.5080.38
123_P163_S0.5070.38
183_I200_A0.5050.37
144_F147_E0.5030.37
164_G208_L0.5020.37
74_P169_I0.5010.37
50_E69_G0.5000.37
73_S81_D0.5000.37
71_A114_Q0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gaaA 5 0.9482 100 0.196 Contact Map
3wz2A 3 0.9084 100 0.202 Contact Map
2wamA 4 0.9402 100 0.226 Contact Map
3vr0A 3 0.8964 100 0.236 Contact Map
2p90A 3 0.9402 100 0.238 Contact Map
3mnfA 4 0.8486 100 0.25 Contact Map
3e35A 3 0.9323 100 0.257 Contact Map
4g4sP 1 0.6653 99.9 0.62 Contact Map
2yy0A 6 0.1952 64.9 0.936 Contact Map
3k92A 5 0.7888 56.1 0.939 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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