GREMLIN Database
Q97ZI3 - Uncharacterized protein
UniProt: Q97ZI3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 333 (312)
Sequences: 381 (298)
Seq/√Len: 16.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_S26_T5.1441.00
15_V37_I4.5611.00
224_Y228_K4.4521.00
43_V55_L4.2511.00
161_E179_N3.9921.00
223_D227_S3.7301.00
158_R180_S3.5651.00
180_S223_D3.3920.99
184_R223_D3.2930.99
158_R223_D3.2660.99
180_S227_S2.9240.98
162_L229_I2.9020.98
184_R227_S2.8270.98
97_F123_V2.7570.97
28_P31_W2.6750.97
159_I311_A2.4970.95
17_K20_S2.3720.94
227_S320_F2.3470.94
259_E278_L2.2810.93
161_E224_Y2.2720.92
228_K314_N2.1490.90
307_L314_N2.1260.90
151_I183_L2.1190.89
18_L23_L2.1170.89
163_S171_T2.1090.89
222_I274_N2.1040.89
22_S134_E2.0610.88
139_T189_M2.0500.88
38_K41_D2.0420.88
314_N320_F2.0370.87
16_Q26_T1.9990.86
184_R317_C1.9700.86
310_N314_N1.9580.85
32_I37_I1.9480.85
180_S184_R1.9460.85
19_G40_G1.9350.85
158_R227_S1.9020.83
223_D320_F1.8900.83
204_T207_Y1.8770.83
13_R28_P1.8610.82
19_G82_N1.8540.82
18_L21_S1.8430.81
224_Y314_N1.8310.81
14_K23_L1.8150.80
23_L30_K1.8130.80
109_E150_R1.7750.79
45_L53_L1.7640.78
182_D185_K1.7600.78
158_R184_R1.7600.78
13_R16_Q1.7200.77
88_Y120_G1.7070.76
13_R31_W1.6810.75
115_S133_L1.6810.75
162_L173_H1.6360.73
11_E14_K1.6310.73
228_K307_L1.6140.72
18_L224_Y1.5850.70
97_F144_V1.5760.70
18_L314_N1.5500.69
20_S23_L1.5480.69
13_R19_G1.5410.68
86_C184_R1.5360.68
144_V200_Q1.5100.67
27_L130_K1.4890.65
225_I311_A1.4700.64
21_S215_N1.4580.64
18_L24_F1.4530.63
165_F173_H1.4460.63
19_G31_W1.4440.63
16_Q19_G1.4080.61
80_L186_I1.4040.61
138_D141_K1.3960.60
227_S317_C1.3920.60
54_R97_F1.3910.60
126_S320_F1.3770.59
35_W137_L1.3690.59
55_L97_F1.3570.58
182_D245_M1.3560.58
27_L31_W1.3540.58
195_I215_N1.3530.58
228_K320_F1.3490.58
71_V208_R1.3470.57
219_L264_A1.3360.57
307_L320_F1.3090.55
272_I318_G1.2980.55
116_K185_K1.2910.54
16_Q22_S1.2850.54
307_L323_D1.2810.54
228_K310_N1.2790.53
25_I38_K1.2720.53
146_S150_R1.2710.53
114_I118_L1.2620.52
36_S275_G1.2600.52
189_M193_R1.2560.52
141_K185_K1.2480.52
151_I226_V1.2470.52
15_V23_L1.2460.51
163_S289_I1.2440.51
155_I162_L1.2400.51
197_N207_Y1.2390.51
184_R320_F1.2270.50
19_G29_K1.2160.50
214_L217_S1.1960.48
86_C223_D1.1730.47
19_G227_S1.1720.47
53_L316_M1.1710.47
16_Q21_S1.1700.47
224_Y320_F1.1660.47
161_E228_K1.1630.47
155_I229_I1.1620.46
41_D154_I1.1520.46
253_I275_G1.1510.46
180_S310_N1.1460.46
122_E182_D1.1410.45
151_I260_I1.1300.45
93_D302_E1.1300.45
122_E184_R1.1270.44
97_F219_L1.1210.44
320_F324_L1.1200.44
121_A276_F1.0960.43
232_I310_N1.0890.42
268_S271_R1.0880.42
223_D228_K1.0870.42
173_H176_G1.0820.42
249_I305_V1.0810.42
257_L315_S1.0750.41
67_K164_K1.0750.41
308_L312_L1.0740.41
115_S123_V1.0720.41
24_F236_F1.0700.41
137_L221_N1.0600.41
246_L308_L1.0590.40
15_V53_L1.0510.40
180_S224_Y1.0500.40
23_L260_I1.0450.40
151_I223_D1.0400.39
183_L261_V1.0380.39
177_I180_S1.0350.39
180_S317_C1.0310.39
121_A185_K1.0300.39
22_S32_I1.0260.39
136_L142_V1.0260.39
55_L264_A1.0160.38
231_Q306_N1.0150.38
18_L320_F1.0140.38
18_L29_K1.0090.38
27_L32_I1.0080.38
16_Q28_P1.0040.37
183_L305_V1.0040.37
19_G28_P0.9890.36
13_R22_S0.9890.36
136_L189_M0.9870.36
36_S131_I0.9810.36
38_K43_V0.9770.36
85_P193_R0.9690.35
322_E326_W0.9640.35
36_S145_E0.9600.35
209_N212_I0.9590.35
191_L217_S0.9520.34
27_L172_I0.9490.34
25_I28_P0.9460.34
45_L103_F0.9450.34
189_M204_T0.9450.34
191_L214_L0.9400.34
184_R228_K0.9360.34
133_L279_I0.9350.34
24_F224_Y0.9340.34
118_L188_L0.9300.33
96_V130_K0.9230.33
45_L55_L0.9220.33
245_M292_S0.9200.33
41_D324_L0.9180.33
140_E240_P0.9140.32
126_S180_S0.9100.32
17_K222_I0.9060.32
65_G274_N0.9050.32
112_L116_K0.9050.32
263_S272_I0.8980.32
131_I181_D0.8950.31
161_E172_I0.8910.31
125_E179_N0.8910.31
21_S56_I0.8900.31
178_S200_Q0.8890.31
171_T289_I0.8890.31
317_C320_F0.8880.31
110_E165_F0.8880.31
168_N251_T0.8850.31
223_D226_V0.8850.31
314_N324_L0.8820.31
22_S52_S0.8810.31
126_S179_N0.8800.31
320_F323_D0.8770.31
45_L206_Y0.8720.30
13_R25_I0.8720.30
132_K240_P0.8690.30
124_V277_N0.8690.30
315_S319_I0.8680.30
22_S42_K0.8670.30
79_P100_K0.8670.30
98_E185_K0.8670.30
220_I226_V0.8650.30
15_V186_I0.8630.30
49_D182_D0.8620.30
17_K22_S0.8600.30
114_I188_L0.8590.30
224_Y307_L0.8590.30
14_K21_S0.8590.30
180_S320_F0.8570.30
197_N264_A0.8560.30
224_Y310_N0.8520.29
151_I180_S0.8460.29
155_I226_V0.8440.29
45_L241_S0.8430.29
95_I239_S0.8390.29
175_S179_N0.8380.29
16_Q20_S0.8380.29
163_S247_K0.8340.28
166_L236_F0.8310.28
27_L37_I0.8260.28
21_S57_A0.8230.28
155_I253_I0.8210.28
131_I238_V0.8180.28
64_A113_Y0.8130.27
99_T103_F0.8110.27
20_S24_F0.8100.27
181_D189_M0.8090.27
240_P245_M0.8070.27
306_N320_F0.8050.27
18_L264_A0.8040.27
40_G82_N0.8020.27
214_L221_N0.8020.27
22_S28_P0.8010.27
15_V35_W0.8000.27
244_D275_G0.7960.27
251_T274_N0.7900.26
20_S133_L0.7890.26
172_I233_K0.7890.26
148_L292_S0.7890.26
179_N224_Y0.7890.26
22_S116_K0.7860.26
176_G253_I0.7820.26
147_L190_L0.7800.26
118_L192_R0.7780.26
303_D306_N0.7770.26
217_S321_L0.7750.26
86_C204_T0.7740.26
122_E150_R0.7700.25
160_D171_T0.7670.25
29_K136_L0.7670.25
117_H308_L0.7640.25
16_Q31_W0.7610.25
185_K220_I0.7600.25
312_L319_I0.7590.25
94_E134_E0.7580.25
84_I140_E0.7570.25
40_G57_A0.7560.25
27_L52_S0.7560.25
196_G213_L0.7530.25
71_V231_Q0.7500.25
234_D248_S0.7500.25
89_I188_L0.7450.24
18_L126_S0.7420.24
25_I31_W0.7410.24
80_L246_L0.7400.24
132_K262_M0.7390.24
228_K318_G0.7350.24
144_V157_K0.7350.24
11_E52_S0.7350.24
123_V126_S0.7350.24
98_E129_K0.7320.24
167_T311_A0.7280.24
305_V312_L0.7280.24
128_E269_V0.7270.24
63_N284_Q0.7220.23
307_L310_N0.7220.23
55_L270_K0.7180.23
242_Q288_K0.7130.23
123_V288_K0.7130.23
185_K276_F0.7110.23
310_N317_C0.7100.23
40_G118_L0.7090.23
55_L251_T0.7080.23
45_L188_L0.7060.23
136_L185_K0.7040.23
131_I301_L0.7040.23
274_N278_L0.7010.22
260_I272_I0.6980.22
160_D182_D0.6960.22
136_L180_S0.6930.22
22_S135_C0.6920.22
15_V231_Q0.6910.22
53_L160_D0.6900.22
161_E175_S0.6890.22
18_L26_T0.6890.22
249_I255_D0.6870.22
15_V39_P0.6870.22
272_I276_F0.6860.22
95_I247_K0.6860.22
56_I86_C0.6850.22
161_E268_S0.6850.22
164_K172_I0.6850.22
43_V63_N0.6820.22
193_R196_G0.6820.22
15_V158_R0.6790.22
64_A148_L0.6750.21
126_S273_S0.6750.21
158_R226_V0.6740.21
174_Q288_K0.6740.21
67_K93_D0.6730.21
146_S153_N0.6700.21
88_Y320_F0.6680.21
167_T244_D0.6660.21
132_K164_K0.6650.21
118_L151_I0.6630.21
105_K207_Y0.6580.21
19_G22_S0.6570.21
82_N272_I0.6570.21
22_S31_W0.6570.21
127_S247_K0.6530.21
140_E164_K0.6510.20
164_K168_N0.6480.20
139_T203_S0.6480.20
37_I154_I0.6460.20
147_L212_I0.6450.20
193_R197_N0.6440.20
195_I211_L0.6440.20
191_L200_Q0.6400.20
277_N304_L0.6370.20
184_R224_Y0.6340.20
38_K241_S0.6330.20
72_D76_L0.6330.20
150_R153_N0.6290.20
263_S322_E0.6290.20
57_A147_L0.6270.20
27_L124_V0.6260.19
97_F164_K0.6240.19
38_K270_K0.6240.19
99_T126_S0.6230.19
244_D285_N0.6210.19
111_V292_S0.6200.19
97_F284_Q0.6180.19
57_A80_L0.6180.19
127_S130_K0.6160.19
111_V181_D0.6160.19
131_I150_R0.6150.19
276_F279_I0.6150.19
226_V260_I0.6130.19
181_D206_Y0.6120.19
96_V175_S0.6120.19
158_R183_L0.6100.19
73_V103_F0.6100.19
252_S285_N0.6090.19
183_L233_K0.6080.19
119_V137_L0.6080.19
89_I191_L0.6070.19
27_L111_V0.6070.19
171_T183_L0.6020.19
102_D154_I0.6020.19
188_L215_N0.6020.19
105_K266_F0.6010.19
112_L222_I0.6000.19
196_G203_S0.6000.19
158_R177_I0.5990.19
240_P244_D0.5970.18
144_V148_L0.5970.18
39_P157_K0.5930.18
244_D251_T0.5930.18
183_L317_C0.5890.18
193_R282_I0.5890.18
20_S26_T0.5890.18
228_K317_C0.5880.18
27_L78_Q0.5880.18
119_V188_L0.5870.18
165_F263_S0.5860.18
111_V234_D0.5860.18
21_S185_K0.5830.18
164_K288_K0.5820.18
186_I223_D0.5810.18
45_L143_G0.5800.18
84_I303_D0.5790.18
181_D184_R0.5780.18
286_L309_E0.5750.18
63_N248_S0.5750.18
116_K134_E0.5740.18
20_S179_N0.5720.18
146_S211_L0.5710.18
221_N224_Y0.5690.17
23_L198_K0.5690.17
176_G180_S0.5690.17
39_P86_C0.5680.17
165_F169_S0.5680.17
171_T306_N0.5650.17
266_F278_L0.5650.17
194_I317_C0.5640.17
177_I314_N0.5640.17
253_I259_E0.5630.17
14_K33_N0.5620.17
137_L185_K0.5610.17
43_V76_L0.5610.17
115_S221_N0.5610.17
123_V267_P0.5610.17
86_C158_R0.5580.17
172_I176_G0.5580.17
143_G315_S0.5580.17
260_I319_I0.5570.17
26_T31_W0.5560.17
153_N185_K0.5550.17
54_R226_V0.5530.17
67_K154_I0.5510.17
58_E148_L0.5510.17
300_Y304_L0.5500.17
110_E265_L0.5490.17
226_V311_A0.5470.17
71_V74_D0.5460.17
106_K245_M0.5460.17
135_C141_K0.5450.17
86_C227_S0.5440.17
43_V262_M0.5430.17
23_L225_I0.5430.17
39_P141_K0.5420.17
87_L264_A0.5390.16
14_K31_W0.5390.16
29_K272_I0.5380.16
55_L64_A0.5340.16
80_L199_Y0.5340.16
10_I202_S0.5320.16
319_I324_L0.5320.16
122_E224_Y0.5300.16
225_I283_K0.5290.16
78_Q268_S0.5290.16
12_T76_L0.5270.16
181_D232_I0.5270.16
247_K255_D0.5250.16
306_N314_N0.5240.16
183_L226_V0.5230.16
25_I255_D0.5220.16
108_F240_P0.5210.16
216_I314_N0.5210.16
97_F245_M0.5200.16
83_I218_I0.5200.16
229_I311_A0.5180.16
25_I116_K0.5170.16
14_K19_G0.5170.16
280_L285_N0.5170.16
108_F148_L0.5170.16
18_L307_L0.5160.16
18_L56_I0.5150.16
159_I254_N0.5130.16
14_K40_G0.5130.16
82_N322_E0.5100.16
126_S307_L0.5090.15
177_I216_I0.5090.15
196_G205_E0.5080.15
30_K182_D0.5080.15
172_I228_K0.5080.15
246_L253_I0.5070.15
122_E223_D0.5060.15
176_G226_V0.5060.15
82_N185_K0.5050.15
80_L274_N0.5040.15
193_R324_L0.5030.15
93_D195_I0.5030.15
124_V217_S0.5030.15
118_L143_G0.5030.15
190_L265_L0.5010.15
229_I233_K0.5010.15
160_D258_D0.5000.15
10_I89_I0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1sumB 2 0.5916 99.7 0.788 Contact Map
2i0mA 2 0.5736 99.7 0.792 Contact Map
1xwmA 2 0.5856 99.7 0.795 Contact Map
1t72A 5 0.5946 99.7 0.797 Contact Map
4q25A 2 0.5796 99.6 0.804 Contact Map
2oltA 5 0.5556 99.4 0.83 Contact Map
2mrnA 2 0.1712 98.6 0.878 Contact Map
3o27A 2 0.1742 98.2 0.889 Contact Map
3l39A 3 0.5646 98.1 0.892 Contact Map
1mvfD 1 0.1321 98 0.895 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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