Q97ZI3 - SULSO - GREMLIN Contacts

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Q97ZI3 - Uncharacterized protein

UniProt:	Q97ZI3	Sequences: MSEEKIARDIETRKVQKLGSSSLFITLPKKWINKWSIKPGDKVILEALDDGSLRLIAEKAKTNAGRKTILVDVDSLKQPLINIIPCLYILGFDEIVFETKKDFNKKDFEEVLYISKHLVGAEVVESSEKKIKLECLLDTEKVGVESLLRRILNIISKRIDELSKFLTNSHTIHQSGISNSDDLRKIYLMLLRRIIGNKYQSSSTEYYRNSLILLNISILINIDYIVSKIYQIKDNFEVSPSQTDMLKSIFTSINDVLDEIVMSALFPSVKRISNGFNLILQIKQNLLKIKDSLPNSFNLYLEDLVNLLENALNNSMCGIFLEDLPWIEKDLTA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	333 (312)
Sequences:	381 (298)
Seq/√Len:	16.9

HALSA - Q9HRB9 Q9HS09
SULSO - Q97ZI3 Q980F5 Q7LXS0 Q97VK4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
22_S	26_T	5.144	1.00
15_V	37_I	4.561	1.00
224_Y	228_K	4.452	1.00
43_V	55_L	4.251	1.00
161_E	179_N	3.992	1.00
223_D	227_S	3.730	1.00
158_R	180_S	3.565	1.00
180_S	223_D	3.392	0.99
184_R	223_D	3.293	0.99
158_R	223_D	3.266	0.99
180_S	227_S	2.924	0.98
162_L	229_I	2.902	0.98
184_R	227_S	2.827	0.98
97_F	123_V	2.757	0.97
28_P	31_W	2.675	0.97
159_I	311_A	2.497	0.95
17_K	20_S	2.372	0.94
227_S	320_F	2.347	0.94
259_E	278_L	2.281	0.93
161_E	224_Y	2.272	0.92
228_K	314_N	2.149	0.90
307_L	314_N	2.126	0.90
151_I	183_L	2.119	0.89
18_L	23_L	2.117	0.89
163_S	171_T	2.109	0.89
222_I	274_N	2.104	0.89
22_S	134_E	2.061	0.88
139_T	189_M	2.050	0.88
38_K	41_D	2.042	0.88
314_N	320_F	2.037	0.87
16_Q	26_T	1.999	0.86
184_R	317_C	1.970	0.86
310_N	314_N	1.958	0.85
32_I	37_I	1.948	0.85
180_S	184_R	1.946	0.85
19_G	40_G	1.935	0.85
158_R	227_S	1.902	0.83
223_D	320_F	1.890	0.83
204_T	207_Y	1.877	0.83
13_R	28_P	1.861	0.82
19_G	82_N	1.854	0.82
18_L	21_S	1.843	0.81
224_Y	314_N	1.831	0.81
14_K	23_L	1.815	0.80
23_L	30_K	1.813	0.80
109_E	150_R	1.775	0.79
45_L	53_L	1.764	0.78
182_D	185_K	1.760	0.78
158_R	184_R	1.760	0.78
13_R	16_Q	1.720	0.77
88_Y	120_G	1.707	0.76
13_R	31_W	1.681	0.75
115_S	133_L	1.681	0.75
162_L	173_H	1.636	0.73
11_E	14_K	1.631	0.73
228_K	307_L	1.614	0.72
18_L	224_Y	1.585	0.70
97_F	144_V	1.576	0.70
18_L	314_N	1.550	0.69
20_S	23_L	1.548	0.69
13_R	19_G	1.541	0.68
86_C	184_R	1.536	0.68
144_V	200_Q	1.510	0.67
27_L	130_K	1.489	0.65
225_I	311_A	1.470	0.64
21_S	215_N	1.458	0.64
18_L	24_F	1.453	0.63
165_F	173_H	1.446	0.63
19_G	31_W	1.444	0.63
16_Q	19_G	1.408	0.61
80_L	186_I	1.404	0.61
138_D	141_K	1.396	0.60
227_S	317_C	1.392	0.60
54_R	97_F	1.391	0.60
126_S	320_F	1.377	0.59
35_W	137_L	1.369	0.59
55_L	97_F	1.357	0.58
182_D	245_M	1.356	0.58
27_L	31_W	1.354	0.58
195_I	215_N	1.353	0.58
228_K	320_F	1.349	0.58
71_V	208_R	1.347	0.57
219_L	264_A	1.336	0.57
307_L	320_F	1.309	0.55
272_I	318_G	1.298	0.55
116_K	185_K	1.291	0.54
16_Q	22_S	1.285	0.54
307_L	323_D	1.281	0.54
228_K	310_N	1.279	0.53
25_I	38_K	1.272	0.53
146_S	150_R	1.271	0.53
114_I	118_L	1.262	0.52
36_S	275_G	1.260	0.52
189_M	193_R	1.256	0.52
141_K	185_K	1.248	0.52
151_I	226_V	1.247	0.52
15_V	23_L	1.246	0.51
163_S	289_I	1.244	0.51
155_I	162_L	1.240	0.51
197_N	207_Y	1.239	0.51
184_R	320_F	1.227	0.50
19_G	29_K	1.216	0.50
214_L	217_S	1.196	0.48
86_C	223_D	1.173	0.47
19_G	227_S	1.172	0.47
53_L	316_M	1.171	0.47
16_Q	21_S	1.170	0.47
224_Y	320_F	1.166	0.47
161_E	228_K	1.163	0.47
155_I	229_I	1.162	0.46
41_D	154_I	1.152	0.46
253_I	275_G	1.151	0.46
180_S	310_N	1.146	0.46
122_E	182_D	1.141	0.45
151_I	260_I	1.130	0.45
93_D	302_E	1.130	0.45
122_E	184_R	1.127	0.44
97_F	219_L	1.121	0.44
320_F	324_L	1.120	0.44
121_A	276_F	1.096	0.43
232_I	310_N	1.089	0.42
268_S	271_R	1.088	0.42
223_D	228_K	1.087	0.42
173_H	176_G	1.082	0.42
249_I	305_V	1.081	0.42
257_L	315_S	1.075	0.41
67_K	164_K	1.075	0.41
308_L	312_L	1.074	0.41
115_S	123_V	1.072	0.41
24_F	236_F	1.070	0.41
137_L	221_N	1.060	0.41
246_L	308_L	1.059	0.40
15_V	53_L	1.051	0.40
180_S	224_Y	1.050	0.40
23_L	260_I	1.045	0.40
151_I	223_D	1.040	0.39
183_L	261_V	1.038	0.39
177_I	180_S	1.035	0.39
180_S	317_C	1.031	0.39
121_A	185_K	1.030	0.39
22_S	32_I	1.026	0.39
136_L	142_V	1.026	0.39
55_L	264_A	1.016	0.38
231_Q	306_N	1.015	0.38
18_L	320_F	1.014	0.38
18_L	29_K	1.009	0.38
27_L	32_I	1.008	0.38
16_Q	28_P	1.004	0.37
183_L	305_V	1.004	0.37
19_G	28_P	0.989	0.36
13_R	22_S	0.989	0.36
136_L	189_M	0.987	0.36
36_S	131_I	0.981	0.36
38_K	43_V	0.977	0.36
85_P	193_R	0.969	0.35
322_E	326_W	0.964	0.35
36_S	145_E	0.960	0.35
209_N	212_I	0.959	0.35
191_L	217_S	0.952	0.34
27_L	172_I	0.949	0.34
25_I	28_P	0.946	0.34
45_L	103_F	0.945	0.34
189_M	204_T	0.945	0.34
191_L	214_L	0.940	0.34
184_R	228_K	0.936	0.34
133_L	279_I	0.935	0.34
24_F	224_Y	0.934	0.34
118_L	188_L	0.930	0.33
96_V	130_K	0.923	0.33
45_L	55_L	0.922	0.33
245_M	292_S	0.920	0.33
41_D	324_L	0.918	0.33
140_E	240_P	0.914	0.32
126_S	180_S	0.910	0.32
17_K	222_I	0.906	0.32
65_G	274_N	0.905	0.32
112_L	116_K	0.905	0.32
263_S	272_I	0.898	0.32
131_I	181_D	0.895	0.31
161_E	172_I	0.891	0.31
125_E	179_N	0.891	0.31
21_S	56_I	0.890	0.31
178_S	200_Q	0.889	0.31
171_T	289_I	0.889	0.31
317_C	320_F	0.888	0.31
110_E	165_F	0.888	0.31
168_N	251_T	0.885	0.31
223_D	226_V	0.885	0.31
314_N	324_L	0.882	0.31
22_S	52_S	0.881	0.31
126_S	179_N	0.880	0.31
320_F	323_D	0.877	0.31
45_L	206_Y	0.872	0.30
13_R	25_I	0.872	0.30
132_K	240_P	0.869	0.30
124_V	277_N	0.869	0.30
315_S	319_I	0.868	0.30
22_S	42_K	0.867	0.30
79_P	100_K	0.867	0.30
98_E	185_K	0.867	0.30
220_I	226_V	0.865	0.30
15_V	186_I	0.863	0.30
49_D	182_D	0.862	0.30
17_K	22_S	0.860	0.30
114_I	188_L	0.859	0.30
224_Y	307_L	0.859	0.30
14_K	21_S	0.859	0.30
180_S	320_F	0.857	0.30
197_N	264_A	0.856	0.30
224_Y	310_N	0.852	0.29
151_I	180_S	0.846	0.29
155_I	226_V	0.844	0.29
45_L	241_S	0.843	0.29
95_I	239_S	0.839	0.29
175_S	179_N	0.838	0.29
16_Q	20_S	0.838	0.29
163_S	247_K	0.834	0.28
166_L	236_F	0.831	0.28
27_L	37_I	0.826	0.28
21_S	57_A	0.823	0.28
155_I	253_I	0.821	0.28
131_I	238_V	0.818	0.28
64_A	113_Y	0.813	0.27
99_T	103_F	0.811	0.27
20_S	24_F	0.810	0.27
181_D	189_M	0.809	0.27
240_P	245_M	0.807	0.27
306_N	320_F	0.805	0.27
18_L	264_A	0.804	0.27
40_G	82_N	0.802	0.27
214_L	221_N	0.802	0.27
22_S	28_P	0.801	0.27
15_V	35_W	0.800	0.27
244_D	275_G	0.796	0.27
251_T	274_N	0.790	0.26
20_S	133_L	0.789	0.26
172_I	233_K	0.789	0.26
148_L	292_S	0.789	0.26
179_N	224_Y	0.789	0.26
22_S	116_K	0.786	0.26
176_G	253_I	0.782	0.26
147_L	190_L	0.780	0.26
118_L	192_R	0.778	0.26
303_D	306_N	0.777	0.26
217_S	321_L	0.775	0.26
86_C	204_T	0.774	0.26
122_E	150_R	0.770	0.25
160_D	171_T	0.767	0.25
29_K	136_L	0.767	0.25
117_H	308_L	0.764	0.25
16_Q	31_W	0.761	0.25
185_K	220_I	0.760	0.25
312_L	319_I	0.759	0.25
94_E	134_E	0.758	0.25
84_I	140_E	0.757	0.25
40_G	57_A	0.756	0.25
27_L	52_S	0.756	0.25
196_G	213_L	0.753	0.25
71_V	231_Q	0.750	0.25
234_D	248_S	0.750	0.25
89_I	188_L	0.745	0.24
18_L	126_S	0.742	0.24
25_I	31_W	0.741	0.24
80_L	246_L	0.740	0.24
132_K	262_M	0.739	0.24
228_K	318_G	0.735	0.24
144_V	157_K	0.735	0.24
11_E	52_S	0.735	0.24
123_V	126_S	0.735	0.24
98_E	129_K	0.732	0.24
167_T	311_A	0.728	0.24
305_V	312_L	0.728	0.24
128_E	269_V	0.727	0.24
63_N	284_Q	0.722	0.23
307_L	310_N	0.722	0.23
55_L	270_K	0.718	0.23
242_Q	288_K	0.713	0.23
123_V	288_K	0.713	0.23
185_K	276_F	0.711	0.23
310_N	317_C	0.710	0.23
40_G	118_L	0.709	0.23
55_L	251_T	0.708	0.23
45_L	188_L	0.706	0.23
136_L	185_K	0.704	0.23
131_I	301_L	0.704	0.23
274_N	278_L	0.701	0.22
260_I	272_I	0.698	0.22
160_D	182_D	0.696	0.22
136_L	180_S	0.693	0.22
22_S	135_C	0.692	0.22
15_V	231_Q	0.691	0.22
53_L	160_D	0.690	0.22
161_E	175_S	0.689	0.22
18_L	26_T	0.689	0.22
249_I	255_D	0.687	0.22
15_V	39_P	0.687	0.22
272_I	276_F	0.686	0.22
95_I	247_K	0.686	0.22
56_I	86_C	0.685	0.22
161_E	268_S	0.685	0.22
164_K	172_I	0.685	0.22
43_V	63_N	0.682	0.22
193_R	196_G	0.682	0.22
15_V	158_R	0.679	0.22
64_A	148_L	0.675	0.21
126_S	273_S	0.675	0.21
158_R	226_V	0.674	0.21
174_Q	288_K	0.674	0.21
67_K	93_D	0.673	0.21
146_S	153_N	0.670	0.21
88_Y	320_F	0.668	0.21
167_T	244_D	0.666	0.21
132_K	164_K	0.665	0.21
118_L	151_I	0.663	0.21
105_K	207_Y	0.658	0.21
19_G	22_S	0.657	0.21
82_N	272_I	0.657	0.21
22_S	31_W	0.657	0.21
127_S	247_K	0.653	0.21
140_E	164_K	0.651	0.20
164_K	168_N	0.648	0.20
139_T	203_S	0.648	0.20
37_I	154_I	0.646	0.20
147_L	212_I	0.645	0.20
193_R	197_N	0.644	0.20
195_I	211_L	0.644	0.20
191_L	200_Q	0.640	0.20
277_N	304_L	0.637	0.20
184_R	224_Y	0.634	0.20
38_K	241_S	0.633	0.20
72_D	76_L	0.633	0.20
150_R	153_N	0.629	0.20
263_S	322_E	0.629	0.20
57_A	147_L	0.627	0.20
27_L	124_V	0.626	0.19
97_F	164_K	0.624	0.19
38_K	270_K	0.624	0.19
99_T	126_S	0.623	0.19
244_D	285_N	0.621	0.19
111_V	292_S	0.620	0.19
97_F	284_Q	0.618	0.19
57_A	80_L	0.618	0.19
127_S	130_K	0.616	0.19
111_V	181_D	0.616	0.19
131_I	150_R	0.615	0.19
276_F	279_I	0.615	0.19
226_V	260_I	0.613	0.19
181_D	206_Y	0.612	0.19
96_V	175_S	0.612	0.19
158_R	183_L	0.610	0.19
73_V	103_F	0.610	0.19
252_S	285_N	0.609	0.19
183_L	233_K	0.608	0.19
119_V	137_L	0.608	0.19
89_I	191_L	0.607	0.19
27_L	111_V	0.607	0.19
171_T	183_L	0.602	0.19
102_D	154_I	0.602	0.19
188_L	215_N	0.602	0.19
105_K	266_F	0.601	0.19
112_L	222_I	0.600	0.19
196_G	203_S	0.600	0.19
158_R	177_I	0.599	0.19
240_P	244_D	0.597	0.18
144_V	148_L	0.597	0.18
39_P	157_K	0.593	0.18
244_D	251_T	0.593	0.18
183_L	317_C	0.589	0.18
193_R	282_I	0.589	0.18
20_S	26_T	0.589	0.18
228_K	317_C	0.588	0.18
27_L	78_Q	0.588	0.18
119_V	188_L	0.587	0.18
165_F	263_S	0.586	0.18
111_V	234_D	0.586	0.18
21_S	185_K	0.583	0.18
164_K	288_K	0.582	0.18
186_I	223_D	0.581	0.18
45_L	143_G	0.580	0.18
84_I	303_D	0.579	0.18
181_D	184_R	0.578	0.18
286_L	309_E	0.575	0.18
63_N	248_S	0.575	0.18
116_K	134_E	0.574	0.18
20_S	179_N	0.572	0.18
146_S	211_L	0.571	0.18
221_N	224_Y	0.569	0.17
23_L	198_K	0.569	0.17
176_G	180_S	0.569	0.17
39_P	86_C	0.568	0.17
165_F	169_S	0.568	0.17
171_T	306_N	0.565	0.17
266_F	278_L	0.565	0.17
194_I	317_C	0.564	0.17
177_I	314_N	0.564	0.17
253_I	259_E	0.563	0.17
14_K	33_N	0.562	0.17
137_L	185_K	0.561	0.17
43_V	76_L	0.561	0.17
115_S	221_N	0.561	0.17
123_V	267_P	0.561	0.17
86_C	158_R	0.558	0.17
172_I	176_G	0.558	0.17
143_G	315_S	0.558	0.17
260_I	319_I	0.557	0.17
26_T	31_W	0.556	0.17
153_N	185_K	0.555	0.17
54_R	226_V	0.553	0.17
67_K	154_I	0.551	0.17
58_E	148_L	0.551	0.17
300_Y	304_L	0.550	0.17
110_E	265_L	0.549	0.17
226_V	311_A	0.547	0.17
71_V	74_D	0.546	0.17
106_K	245_M	0.546	0.17
135_C	141_K	0.545	0.17
86_C	227_S	0.544	0.17
43_V	262_M	0.543	0.17
23_L	225_I	0.543	0.17
39_P	141_K	0.542	0.17
87_L	264_A	0.539	0.16
14_K	31_W	0.539	0.16
29_K	272_I	0.538	0.16
55_L	64_A	0.534	0.16
80_L	199_Y	0.534	0.16
10_I	202_S	0.532	0.16
319_I	324_L	0.532	0.16
122_E	224_Y	0.530	0.16
225_I	283_K	0.529	0.16
78_Q	268_S	0.529	0.16
12_T	76_L	0.527	0.16
181_D	232_I	0.527	0.16
247_K	255_D	0.525	0.16
306_N	314_N	0.524	0.16
183_L	226_V	0.523	0.16
25_I	255_D	0.522	0.16
108_F	240_P	0.521	0.16
216_I	314_N	0.521	0.16
97_F	245_M	0.520	0.16
83_I	218_I	0.520	0.16
229_I	311_A	0.518	0.16
25_I	116_K	0.517	0.16
14_K	19_G	0.517	0.16
280_L	285_N	0.517	0.16
108_F	148_L	0.517	0.16
18_L	307_L	0.516	0.16
18_L	56_I	0.515	0.16
159_I	254_N	0.513	0.16
14_K	40_G	0.513	0.16
82_N	322_E	0.510	0.16
126_S	307_L	0.509	0.15
177_I	216_I	0.509	0.15
196_G	205_E	0.508	0.15
30_K	182_D	0.508	0.15
172_I	228_K	0.508	0.15
246_L	253_I	0.507	0.15
122_E	223_D	0.506	0.15
176_G	226_V	0.506	0.15
82_N	185_K	0.505	0.15
80_L	274_N	0.504	0.15
193_R	324_L	0.503	0.15
93_D	195_I	0.503	0.15
124_V	217_S	0.503	0.15
118_L	143_G	0.503	0.15
190_L	265_L	0.501	0.15
229_I	233_K	0.501	0.15
160_D	258_D	0.500	0.15
10_I	89_I	0.500	0.15

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1sumB	2	0.5916	99.7	0.788	Contact Map
2i0mA	2	0.5736	99.7	0.792	Contact Map
1xwmA	2	0.5856	99.7	0.795	Contact Map
1t72A	5	0.5946	99.7	0.797	Contact Map
4q25A	2	0.5796	99.6	0.804	Contact Map
2oltA	5	0.5556	99.4	0.83	Contact Map
2mrnA	2	0.1712	98.6	0.878	Contact Map
3o27A	2	0.1742	98.2	0.889	Contact Map
3l39A	3	0.5646	98.1	0.892	Contact Map
1mvfD	1	0.1321	98	0.895	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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