GREMLIN Database
Q97ZI1 - Uncharacterized protein
UniProt: Q97ZI1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 479 (412)
Sequences: 3175 (1686)
Seq/√Len: 83.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
204_K235_Y5.0391.00
289_A293_S4.7831.00
201_K232_E4.6181.00
201_K231_D4.2941.00
230_A267_I4.2851.00
230_A234_S4.1821.00
263_K291_E4.1121.00
232_E263_K3.8911.00
263_K290_D3.7381.00
436_D439_E3.5811.00
264_N292_N3.5781.00
330_T364_G3.4411.00
261_A265_A3.3531.00
154_M197_V3.2981.00
235_Y266_Y3.2711.00
232_E262_K3.2571.00
318_K349_Y3.1891.00
349_Y380_G3.1431.00
198_Y231_D3.1171.00
287_A295_V3.1021.00
437_E441_T3.0691.00
292_N319_N3.0481.00
261_A295_V2.9321.00
156_P159_E2.9221.00
236_I267_I2.9081.00
233_G264_N2.7791.00
261_A293_S2.7621.00
318_K348_P2.7051.00
266_Y294_T2.6861.00
170_E262_K2.5881.00
259_L267_I2.5771.00
55_E59_K2.5441.00
328_T358_N2.5081.00
344_I375_N2.4941.00
145_I149_K2.3621.00
379_V408_E2.3481.00
380_G410_D2.3351.00
153_V198_Y2.2961.00
321_S351_K2.2941.00
288_W316_R2.2921.00
187_H225_H2.2751.00
64_G188_G2.2601.00
202_N233_G2.2461.00
230_A265_A2.2441.00
316_R346_A2.2261.00
345_H352_S2.2261.00
210_E241_G2.2221.00
66_E70_K2.1851.00
363_G395_K2.1271.00
365_V399_Y2.1041.00
291_E318_K2.0781.00
60_L188_G2.0731.00
365_V397_K2.0721.00
360_G364_G2.0471.00
230_A236_I2.0191.00
431_M437_E2.0161.00
79_D82_S1.9971.00
175_I260_Y1.9861.00
294_T321_S1.9821.00
384_F414_G1.9321.00
318_K347_A1.9301.00
261_A267_I1.9241.00
199_V236_I1.9151.00
228_L238_F1.8941.00
85_D88_A1.8731.00
251_S279_V1.8701.00
261_A289_A1.8431.00
209_V236_I1.7311.00
353_K382_K1.7251.00
156_P193_G1.6891.00
109_E112_K1.6691.00
315_L350_T1.6601.00
153_V200_P1.6201.00
319_N349_Y1.5921.00
150_K206_T1.5851.00
346_A375_N1.5851.00
333_E363_G1.5761.00
173_M258_E1.5591.00
65_L69_E1.5491.00
57_M161_V1.5301.00
304_S307_S1.5240.99
379_V410_D1.5060.99
330_T337_K1.5030.99
59_K63_K1.4880.99
291_E319_N1.4880.99
136_S216_G1.4800.99
58_L62_L1.4670.99
422_M444_L1.4670.99
314_I344_I1.4660.99
176_F256_M1.4480.99
269_F295_V1.4440.99
387_C400_T1.4440.99
351_K382_K1.4210.99
174_K260_Y1.4080.99
320_A347_A1.4070.99
366_N398_A1.3930.99
198_Y229_I1.3840.99
158_D193_G1.3790.99
205_I236_I1.3460.99
374_V413_V1.3400.99
326_V356_N1.3400.99
67_L70_K1.3330.99
290_D293_S1.3290.99
400_T417_A1.3290.99
381_S411_A1.3170.99
320_A350_T1.3140.98
165_P169_K1.3060.98
159_E163_K1.2950.98
374_V381_S1.2890.98
347_A350_T1.2870.98
86_I183_F1.2860.98
56_W169_K1.2780.98
52_K162_S1.2540.98
152_V199_V1.2510.98
234_S267_I1.2500.98
332_G362_N1.2390.98
66_E69_E1.2370.98
160_A196_F1.2310.98
173_M187_H1.2300.98
213_F242_C1.2250.98
84_L306_Y1.2240.98
263_K292_N1.2160.97
171_Y229_I1.2160.97
369_R401_Y1.2150.97
359_I449_I1.2150.97
372_V383_A1.2150.97
290_D317_G1.2120.97
63_K66_E1.2080.97
336_W367_V1.2080.97
327_V449_I1.2070.97
199_V230_A1.1890.97
149_K152_V1.1870.97
264_N319_N1.1860.97
360_G398_A1.1830.97
377_G408_E1.1800.97
378_A381_S1.1800.97
237_H268_K1.1800.97
237_H270_T1.1570.97
290_D316_R1.1470.96
173_M225_H1.1450.96
73_T183_F1.1410.96
275_W281_N1.1370.96
155_L159_E1.1360.96
339_S356_N1.1350.96
128_G207_T1.1320.96
289_A295_V1.1290.96
84_L336_W1.1180.96
314_I346_A1.1160.96
60_L63_K1.1150.96
145_I148_M1.1110.96
67_L71_L1.1040.96
108_P112_K1.0980.95
313_T322_S1.0980.95
155_L163_K1.0950.95
55_E58_L1.0940.95
406_V411_A1.0880.95
225_H256_M1.0880.95
374_V406_V1.0830.95
197_V209_V1.0800.95
204_K233_G1.0730.95
171_Y260_Y1.0650.95
300_G464_L1.0620.94
200_P203_V1.0570.94
367_V401_Y1.0500.94
57_M191_W1.0440.94
63_K67_L1.0340.94
309_V339_S1.0300.94
157_I161_V1.0280.93
199_V205_I1.0250.93
310_Y340_G1.0240.93
229_I260_Y1.0240.93
404_N413_V1.0200.93
306_Y336_W1.0190.93
400_T419_T1.0170.93
288_W314_I1.0080.93
187_H256_M1.0070.93
389_S400_T1.0050.93
153_V196_F1.0010.93
289_A313_T1.0010.93
340_G369_R0.9980.92
152_V203_V0.9910.92
298_V325_L0.9900.92
181_H310_Y0.9860.92
291_E317_G0.9850.92
373_K407_L0.9840.92
289_A322_S0.9810.92
435_I443_M0.9780.92
213_F240_E0.9770.92
269_F297_W0.9740.91
348_P379_V0.9580.91
214_V243_T0.9570.91
372_V381_S0.9550.91
73_T81_L0.9520.91
315_L347_A0.9510.90
188_G225_H0.9500.90
62_L66_E0.9490.90
135_E216_G0.9490.90
155_L160_A0.9460.90
344_I373_K0.9450.90
240_E269_F0.9450.90
134_L139_I0.9390.90
319_N347_A0.9360.90
268_K296_E0.9340.90
262_K290_D0.9320.90
350_T381_S0.9320.90
456_L461_A0.9300.89
72_P182_K0.9280.89
228_L259_L0.9250.89
154_M209_V0.9230.89
360_G366_N0.9230.89
231_D262_K0.9230.89
267_I295_V0.9220.89
374_V405_Q0.9040.88
134_L213_F0.9030.88
67_L178_A0.9020.88
200_P229_I0.9010.88
202_N264_N0.8950.88
213_F226_T0.8930.88
68_F182_K0.8920.87
112_K115_D0.8900.87
461_A465_N0.8880.87
226_T257_V0.8860.87
151_G203_V0.8830.87
172_F191_W0.8820.87
227_L258_E0.8760.86
76_W85_D0.8760.86
160_A168_M0.8730.86
133_V144_K0.8720.86
385_V404_N0.8700.86
271_T283_N0.8630.86
258_E286_R0.8560.85
171_Y227_L0.8540.85
67_L179_S0.8520.85
374_V385_V0.8520.85
373_K405_Q0.8500.85
271_T281_N0.8500.85
385_V413_V0.8490.85
79_D418_H0.8470.85
430_L444_L0.8430.84
57_M172_F0.8420.84
313_T324_S0.8420.84
340_G389_S0.8390.84
331_S362_N0.8380.84
196_F229_I0.8380.84
363_G396_T0.8370.84
242_C281_N0.8330.84
224_E255_G0.8320.84
376_K395_K0.8300.83
271_T275_W0.8280.83
157_I168_M0.8240.83
164_Y167_L0.8210.83
65_L190_L0.8200.83
305_K333_E0.8170.82
199_V234_S0.8170.82
291_E349_Y0.8170.82
403_H414_G0.8130.82
131_V141_S0.8130.82
240_E271_T0.8130.82
342_K373_K0.8110.82
73_T86_I0.8100.82
371_L405_Q0.8090.82
403_H407_L0.8080.82
354_V372_V0.8070.82
133_V136_S0.8040.81
331_S335_E0.8010.81
164_Y196_F0.8000.81
341_S356_N0.8000.81
435_I440_A0.7990.81
307_S337_K0.7980.81
230_A261_A0.7960.81
371_L403_H0.7960.81
406_V410_D0.7950.81
64_G185_A0.7940.81
315_L420_F0.7890.80
201_K263_K0.7870.80
361_F393_D0.7840.80
310_Y369_R0.7840.80
284_N312_S0.7840.80
232_E264_N0.7830.80
374_V382_K0.7810.79
139_I144_K0.7800.79
382_K412_D0.7730.79
215_I222_Q0.7730.79
408_E411_A0.7720.79
181_H284_N0.7700.79
369_R403_H0.7690.78
336_W365_V0.7650.78
146_E149_K0.7610.78
59_K62_L0.7580.77
227_L260_Y0.7570.77
263_K319_N0.7570.77
273_Q335_E0.7560.77
347_A377_G0.7560.77
223_F254_D0.7530.77
303_G307_S0.7520.77
359_I390_L0.7490.77
392_L428_F0.7490.77
341_S354_V0.7460.76
174_K258_E0.7460.76
464_L472_L0.7440.76
290_D320_A0.7440.76
316_R347_A0.7430.76
225_H258_E0.7390.76
202_N232_E0.7380.76
172_F227_L0.7380.76
450_D465_N0.7360.75
338_D369_R0.7360.75
325_L455_E0.7360.75
264_N291_E0.7360.75
262_K293_S0.7340.75
430_L435_I0.7290.75
75_N78_P0.7290.75
309_V356_N0.7270.74
187_H254_D0.7260.74
406_V413_V0.7250.74
379_V412_D0.7240.74
369_R398_A0.7230.74
61_R185_A0.7220.74
346_A377_G0.7200.74
185_A258_E0.7200.74
273_Q304_S0.7160.73
326_V339_S0.7140.73
363_G393_D0.7140.73
354_V357_K0.7130.73
374_V411_A0.7100.73
379_V409_E0.7090.73
287_A313_T0.7080.72
228_L236_I0.7070.72
320_A348_P0.7060.72
343_M352_S0.7060.72
390_L397_K0.7040.72
133_V140_Y0.7040.72
260_Y288_W0.7030.72
253_H275_W0.7010.72
79_D408_E0.7000.72
348_P354_V0.6990.72
168_M196_F0.6970.71
91_L221_G0.6970.71
324_S343_M0.6960.71
330_T360_G0.6960.71
188_G256_M0.6950.71
64_G178_A0.6950.71
360_G396_T0.6930.71
380_G408_E0.6930.71
148_M151_G0.6920.71
167_L198_Y0.6920.71
349_Y379_V0.6900.71
171_Y196_F0.6880.70
132_A136_S0.6860.70
107_P110_I0.6850.70
132_A137_E0.6840.70
273_Q303_G0.6830.70
323_T353_K0.6830.70
236_I261_A0.6820.70
81_L308_F0.6770.69
376_K407_L0.6770.69
286_R417_A0.6730.69
319_N351_K0.6730.69
417_A445_V0.6720.69
60_L169_K0.6710.68
324_S383_A0.6710.68
356_N368_Y0.6680.68
257_V269_F0.6680.68
268_K457_P0.6660.68
173_M227_L0.6660.68
273_Q299_E0.6660.68
183_F282_F0.6650.68
371_L385_V0.6640.68
84_L367_V0.6640.68
376_K379_V0.6620.67
259_L295_V0.6610.67
81_L84_L0.6600.67
383_A389_S0.6600.67
390_L445_V0.6590.67
83_S308_F0.6590.67
374_V408_E0.6580.67
404_N411_A0.6580.67
345_H407_L0.6580.67
167_L196_F0.6570.67
329_M361_F0.6570.67
173_M188_G0.6560.67
336_W356_N0.6560.67
401_Y414_G0.6530.66
285_K311_P0.6520.66
369_R389_S0.6510.66
53_E58_L0.6510.66
422_M441_T0.6500.66
378_A408_E0.6490.66
130_L207_T0.6490.66
79_D308_F0.6490.66
348_P378_A0.6470.66
147_L206_T0.6460.65
108_P111_R0.6460.65
414_G420_F0.6460.65
204_K321_S0.6420.65
131_V138_P0.6410.65
152_V205_I0.6410.65
79_D379_V0.6400.65
195_V226_T0.6390.65
358_N387_C0.6390.65
273_Q301_S0.6390.65
60_L178_A0.6390.65
70_K174_K0.6370.64
107_P151_G0.6370.64
329_M468_I0.6310.64
346_A373_K0.6270.63
128_G197_V0.6230.63
313_T420_F0.6220.63
340_G449_I0.6210.62
340_G387_C0.6210.62
413_V416_E0.6210.62
153_V164_Y0.6210.62
135_E139_I0.6200.62
212_F245_P0.6170.62
63_K178_A0.6170.62
61_R64_G0.6150.62
199_V238_F0.6130.61
167_L170_E0.6120.61
362_N393_D0.6110.61
136_S191_W0.6090.61
380_G409_E0.6090.61
388_D418_H0.6080.61
339_S400_T0.6080.61
407_L420_F0.6070.61
287_A293_S0.6070.61
133_V193_G0.6070.61
318_K380_G0.6060.61
397_K468_I0.6060.61
218_E249_K0.6060.61
381_S413_V0.6060.61
413_V423_N0.6050.60
215_I279_V0.6050.60
340_G400_T0.6050.60
136_S245_P0.6050.60
241_G274_N0.6040.60
331_S430_L0.6040.60
171_Y258_E0.6000.60
295_V313_T0.5990.60
285_K309_V0.5990.60
66_E218_E0.5990.60
81_L403_H0.5980.60
270_T457_P0.5980.60
370_G405_Q0.5980.60
415_H429_Y0.5980.60
406_V409_E0.5970.59
358_N366_N0.5960.59
242_C271_T0.5960.59
418_H449_I0.5950.59
296_E323_T0.5950.59
208_P390_L0.5940.59
335_E362_N0.5940.59
408_E418_H0.5930.59
64_G189_A0.5920.59
180_D286_R0.5920.59
315_L320_A0.5900.59
74_P186_L0.5890.58
172_F303_G0.5890.58
356_N387_C0.5870.58
374_V418_H0.5870.58
111_R114_Y0.5870.58
157_I191_W0.5870.58
253_H281_N0.5860.58
211_G381_S0.5850.58
233_G266_Y0.5840.58
462_T465_N0.5830.58
409_E412_D0.5810.57
309_V420_F0.5800.57
408_E416_E0.5790.57
87_S365_V0.5790.57
53_E62_L0.5790.57
375_N407_L0.5780.57
150_K199_V0.5770.57
354_V385_V0.5770.57
321_S353_K0.5760.57
283_N299_E0.5750.57
251_S275_W0.5750.57
356_N369_R0.5750.57
242_C253_H0.5740.56
301_S328_T0.5730.56
197_V205_I0.5720.56
405_Q408_E0.5720.56
91_L343_M0.5720.56
194_G226_T0.5700.56
263_K320_A0.5700.56
459_E462_T0.5700.56
391_M398_A0.5690.56
289_A320_A0.5690.56
345_H375_N0.5670.56
81_L413_V0.5660.55
160_A164_Y0.5660.55
420_F423_N0.5650.55
52_K55_E0.5640.55
104_E107_P0.5640.55
134_L195_V0.5640.55
235_Y268_K0.5630.55
161_V172_F0.5630.55
143_V227_L0.5630.55
435_I439_E0.5630.55
381_S408_E0.5620.55
442_S469_K0.5610.55
277_K332_G0.5610.55
180_D184_A0.5610.55
157_I196_F0.5600.55
262_K265_A0.5590.55
383_A413_V0.5580.54
288_W313_T0.5580.54
301_S309_V0.5560.54
355_V452_I0.5550.54
150_K205_I0.5550.54
107_P245_P0.5550.54
160_A229_I0.5550.54
65_L68_F0.5550.54
257_V298_V0.5550.54
374_V409_E0.5530.54
146_E207_T0.5530.54
310_Y385_V0.5530.54
232_E293_S0.5520.54
52_K67_L0.5520.54
308_F416_E0.5510.53
331_S361_F0.5510.53
308_F338_D0.5510.53
391_M401_Y0.5500.53
225_H420_F0.5500.53
260_Y290_D0.5500.53
68_F72_P0.5480.53
329_M471_E0.5480.53
263_K293_S0.5480.53
302_L471_E0.5460.53
340_G383_A0.5450.53
342_K371_L0.5450.53
64_G67_L0.5440.53
355_V386_K0.5430.52
83_S379_V0.5420.52
383_A404_N0.5420.52
61_R190_L0.5420.52
65_L159_E0.5420.52
311_P356_N0.5410.52
369_R387_C0.5400.52
290_D318_K0.5400.52
311_P314_I0.5390.52
111_R115_D0.5390.52
189_A265_A0.5390.52
296_E457_P0.5370.52
281_N307_S0.5370.52
157_I194_G0.5360.51
356_N389_S0.5360.51
326_V444_L0.5360.51
343_M394_D0.5360.51
107_P111_R0.5360.51
383_A387_C0.5350.51
238_F257_V0.5330.51
168_M227_L0.5330.51
272_I302_L0.5320.51
401_Y408_E0.5310.51
146_E152_V0.5300.51
213_F222_Q0.5290.51
204_K266_Y0.5280.50
418_H451_E0.5270.50
389_S419_T0.5270.50
215_I253_H0.5250.50
200_P231_D0.5240.50
386_K426_Q0.5230.50
221_G357_K0.5210.50
160_A167_L0.5210.50
355_V423_N0.5210.50
365_V396_T0.5210.50
217_S220_E0.5200.49
466_K469_K0.5200.49
151_G199_V0.5190.49
292_N470_L0.5180.49
195_V211_G0.5180.49
389_S421_R0.5180.49
396_T430_L0.5180.49
282_F308_F0.5170.49
186_L223_F0.5160.49
195_V213_F0.5160.49
430_L471_E0.5160.49
54_P161_V0.5150.49
133_V137_E0.5150.49
331_S424_E0.5130.48
223_F252_F0.5130.48
259_L280_I0.5130.48
114_Y132_A0.5130.48
401_Y409_E0.5130.48
67_L72_P0.5120.48
72_P82_S0.5120.48
368_Y401_Y0.5110.48
453_M468_I0.5110.48
301_S339_S0.5110.48
202_N346_A0.5100.48
111_R466_K0.5100.48
51_K158_D0.5080.48
389_S401_Y0.5080.48
254_D383_A0.5070.48
449_I452_I0.5070.48
340_G356_N0.5070.48
345_H405_Q0.5060.48
413_V444_L0.5060.48
85_D358_N0.5050.47
187_H255_G0.5050.47
161_V168_M0.5050.47
79_D83_S0.5050.47
164_Y200_P0.5040.47
151_G200_P0.5040.47
152_V236_I0.5040.47
60_L64_G0.5040.47
274_N467_V0.5040.47
428_F432_T0.5040.47
114_Y130_L0.5040.47
242_C275_W0.5040.47
214_V221_G0.5030.47
211_G214_V0.5030.47
410_D413_V0.5020.47
213_F245_P0.5020.47
378_A413_V0.5020.47
213_F426_Q0.5010.47
328_T339_S0.5010.47
328_T421_R0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vh4A 2 0.8539 100 0.252 Contact Map
4dn7A 2 0.8455 100 0.288 Contact Map
1rq8A 1 0.119 26 0.977 Contact Map
4v0qA 2 0.1273 25.9 0.977 Contact Map
4k6mA 2 0.1294 21.6 0.978 Contact Map
3uknA 2 0.1148 18.2 0.978 Contact Map
1ifyA 1 0.0898 17.6 0.979 Contact Map
4edgA 1 0.1733 16.7 0.979 Contact Map
4xfmA 2 0.1628 15.4 0.979 Contact Map
1wjiA 1 0.1065 14.8 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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