Q97ZI0 - SULSO - GREMLIN Contacts

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Q97ZI0 - Uncharacterized protein

UniProt:	Q97ZI0	Sequences: MQWLKLGVVDIQLAKKVINENFTQDKGEREKAFSLYLSKPYQLIHDSPTIKHYTEWDLYDSLNLTNISRQEVKYNDTANVIEIIDDTIKIPKNDIQIDDLLNDSIISSDEHKLVSLAYSLSRRITINNEGEYYVKHVLNKDKYFSPSHLIINVPNDKQIKVVYEVLNLSESSLITPIISVNIEDNSSLDFQFVNFSSDNSLLFSYIKANIKGTMHSSIFVNGNKMGHVQFSTRLEESSVSEFSSRAFGTHSNKIDVVNNVIHLGQKSVSNGFMKAISNDQAFTVVRGVATIDETAINSSTSIIGRSLVLGKDAKAVVSPMLEVKTGRVVMAKHSAAVSKIDENQIFYLQTRGLSRREAEGIIIRGFIIEEQDPETLKDRIEEILKSLGY	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	389 (355)
Sequences:	3838 (2270)
Seq/√Len:	120.5

ECOLI - SUFB SUFD
BACSU - SUFD SUFB
HALSA - Q9HRV6 Q9HRV5
SULSO - Q97ZI0 Q97ZI1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
125_T	158_Q	4.631	1.00
153_V	157_K	4.602	1.00
354_S	357_E	4.312	1.00
155_N	184_D	4.198	1.00
158_Q	187_S	4.136	1.00
182_I	186_S	3.886	1.00
153_V	188_L	3.860	1.00
185_N	211_K	3.712	1.00
246_A	275_A	3.534	1.00
155_N	183_E	3.310	1.00
156_D	185_N	3.297	1.00
182_I	214_M	3.288	1.00
248_G	281_A	3.266	1.00
208_A	214_M	3.175	1.00
211_K	237_S	3.009	1.00
187_S	213_T	3.008	1.00
355_R	359_E	2.961	1.00
261_I	292_D	2.923	1.00
236_E	266_K	2.878	1.00
266_K	297_N	2.872	1.00
182_I	212_G	2.863	1.00
159_I	188_L	2.686	1.00
85_D	88_I	2.675	1.00
153_V	186_S	2.592	1.00
262_H	269_S	2.436	1.00
236_E	265_Q	2.397	1.00
209_N	235_E	2.356	1.00
123_R	127_N	2.319	1.00
297_N	327_R	2.297	1.00
213_T	239_V	2.281	1.00
80_V	86_D	2.261	1.00
123_R	156_D	2.240	1.00
180_V	188_L	2.227	1.00
117_A	148_H	2.221	1.00
99_D	183_E	2.210	1.00
270_N	299_S	2.176	1.00
296_I	325_T	2.102	1.00
282_F	316_V	2.090	1.00
282_F	314_K	2.057	1.00
23_T	27_G	2.054	1.00
317_V	335_A	2.003	1.00
234_L	267_S	2.000	1.00
239_V	268_V	1.972	1.00
131_E	164_E	1.952	1.00
235_E	263_L	1.938	1.00
74_Y	78_A	1.924	1.00
349_Q	355_R	1.900	1.00
182_I	188_L	1.892	1.00
34_S	38_S	1.864	1.00
236_E	264_G	1.854	1.00
301_S	332_K	1.817	1.00
153_V	159_I	1.795	1.00
280_Q	312_D	1.793	1.00
283_T	315_A	1.742	1.00
51_K	54_T	1.729	1.00
248_G	254_I	1.717	1.00
32_A	118_Y	1.710	1.00
172_S	200_S	1.701	1.00
182_I	210_I	1.699	1.00
130_G	159_I	1.648	1.00
277_S	281_A	1.638	1.00
223_N	226_G	1.634	1.00
105_I	181_N	1.529	1.00
233_R	261_I	1.520	1.00
28_E	118_Y	1.514	1.00
232_T	240_S	1.486	1.00
160_K	189_D	1.485	1.00
251_S	280_Q	1.483	1.00
237_S	266_K	1.483	1.00
209_N	233_R	1.483	1.00
33_F	37_L	1.482	1.00
83_I	86_D	1.458	1.00
296_I	327_R	1.456	1.00
94_D	98_D	1.446	1.00
160_K	191_Q	1.437	1.00
264_G	267_S	1.437	1.00
151_I	161_V	1.430	1.00
103_D	179_S	1.427	1.00
291_I	331_A	1.422	1.00
126_I	159_I	1.409	1.00
27_G	31_K	1.385	1.00
74_Y	77_T	1.377	1.00
35_L	38_S	1.377	1.00
263_L	292_D	1.372	1.00
25_D	90_I	1.370	1.00
233_R	263_L	1.369	1.00
124_I	127_N	1.364	1.00
55_E	58_L	1.333	1.00
244_S	273_M	1.328	1.00
238_S	267_S	1.328	1.00
152_N	183_E	1.321	1.00
31_K	34_S	1.315	1.00
294_T	325_T	1.308	1.00
26_K	30_E	1.306	1.00
184_D	211_K	1.302	1.00
276_I	367_I	1.286	1.00
54_T	225_M	1.285	1.00
189_D	215_H	1.285	1.00
82_E	85_D	1.282	1.00
238_S	264_G	1.281	1.00
148_H	179_S	1.270	1.00
153_V	182_I	1.270	1.00
190_F	214_M	1.262	0.99
250_H	279_D	1.251	0.99
72_V	77_T	1.242	0.99
277_S	315_A	1.239	0.99
152_N	181_N	1.232	0.99
151_I	180_V	1.229	0.99
340_I	362_I	1.229	0.99
299_S	329_V	1.226	0.99
304_G	317_V	1.224	0.99
232_T	242_F	1.211	0.99
234_L	264_G	1.203	0.99
123_R	128_N	1.198	0.99
23_T	26_K	1.182	0.99
34_S	37_L	1.180	0.99
80_V	85_D	1.179	0.99
289_A	300_T	1.166	0.99
84_I	92_K	1.164	0.99
268_V	299_S	1.164	0.99
179_S	207_K	1.163	0.99
69_R	72_V	1.158	0.99
163_Y	167_N	1.153	0.99
82_E	86_D	1.151	0.99
253_K	284_V	1.134	0.99
106_I	177_I	1.131	0.99
80_V	84_I	1.124	0.99
185_N	237_S	1.121	0.99
88_I	92_K	1.120	0.99
109_D	112_K	1.100	0.99
49_T	53_Y	1.100	0.99
35_L	39_K	1.097	0.99
155_N	185_N	1.094	0.99
54_T	253_K	1.093	0.99
93_N	96_Q	1.078	0.98
245_R	367_I	1.073	0.98
31_K	35_L	1.067	0.98
298_S	328_V	1.064	0.98
28_E	31_K	1.062	0.98
56_W	113_L	1.061	0.98
291_I	298_S	1.060	0.98
146_P	175_T	1.056	0.98
49_T	52_H	1.056	0.98
241_E	270_N	1.055	0.98
295_A	298_S	1.040	0.98
89_K	97_I	1.039	0.98
100_L	152_N	1.039	0.98
225_M	253_K	1.037	0.98
49_T	54_T	1.029	0.98
70_Q	74_Y	1.028	0.98
289_A	298_S	1.028	0.98
290_T	324_K	1.026	0.98
134_V	165_V	1.017	0.98
149_L	178_I	1.017	0.98
286_R	318_S	1.015	0.98
71_E	74_Y	1.015	0.98
24_Q	98_D	1.013	0.98
135_K	166_L	1.009	0.98
267_S	298_S	1.008	0.98
317_V	337_V	1.008	0.98
123_R	129_E	1.007	0.98
30_E	34_S	1.006	0.97
100_L	181_N	0.993	0.97
374_E	380_I	0.985	0.97
329_V	332_K	0.982	0.97
43_L	46_D	0.981	0.97
171_S	199_N	0.981	0.97
84_I	88_I	0.981	0.97
377_K	380_I	0.978	0.97
124_I	129_E	0.977	0.97
249_T	252_N	0.975	0.97
27_G	30_E	0.973	0.97
163_Y	190_F	0.972	0.97
68_S	72_V	0.964	0.97
116_L	120_L	0.952	0.97
111_H	117_A	0.952	0.97
210_I	232_T	0.947	0.96
184_D	238_S	0.945	0.96
234_L	238_S	0.944	0.96
123_R	155_N	0.941	0.96
112_K	117_A	0.939	0.96
377_K	381_E	0.934	0.96
68_S	71_E	0.933	0.96
112_K	115_S	0.932	0.96
248_G	283_T	0.930	0.96
278_N	310_G	0.929	0.96
79_N	86_D	0.929	0.96
79_N	127_N	0.928	0.96
190_F	216_S	0.928	0.96
58_L	224_K	0.927	0.96
117_A	177_I	0.923	0.96
36_Y	112_K	0.922	0.96
184_D	212_G	0.921	0.96
154_P	183_E	0.920	0.96
196_S	202_L	0.918	0.96
111_H	229_Q	0.913	0.96
328_V	331_A	0.913	0.96
265_Q	295_A	0.912	0.96
84_I	89_K	0.909	0.95
106_I	109_D	0.907	0.95
260_V	269_S	0.904	0.95
291_I	302_I	0.902	0.95
208_A	232_T	0.901	0.95
194_N	222_G	0.900	0.95
290_T	322_E	0.899	0.95
284_V	318_S	0.898	0.95
207_K	231_S	0.895	0.95
164_E	382_E	0.893	0.95
284_V	287_G	0.893	0.95
164_E	195_F	0.887	0.95
25_D	121_S	0.885	0.95
217_S	243_S	0.881	0.95
51_K	59_Y	0.874	0.94
306_S	317_V	0.870	0.94
205_Y	231_S	0.870	0.94
261_I	290_T	0.869	0.94
81_I	84_I	0.868	0.94
81_I	124_I	0.867	0.94
288_V	320_M	0.865	0.94
266_K	296_I	0.863	0.94
80_V	83_I	0.861	0.94
229_Q	257_V	0.860	0.94
56_W	61_S	0.859	0.94
293_E	324_K	0.852	0.94
300_T	331_A	0.851	0.94
256_V	273_M	0.849	0.93
180_V	190_F	0.847	0.93
257_V	286_R	0.844	0.93
137_V	166_L	0.843	0.93
62_L	65_T	0.842	0.93
291_I	323_V	0.839	0.93
180_V	214_M	0.839	0.93
134_V	149_L	0.832	0.93
147_S	176_P	0.828	0.93
210_I	214_M	0.827	0.93
163_Y	192_F	0.826	0.93
104_S	181_N	0.824	0.92
86_D	90_I	0.823	0.92
307_L	363_I	0.820	0.92
111_H	118_Y	0.819	0.92
325_T	328_V	0.817	0.92
265_Q	296_I	0.815	0.92
140_K	143_Y	0.813	0.92
116_L	119_S	0.808	0.92
368_I	372_D	0.805	0.92
222_G	226_G	0.804	0.91
102_N	150_I	0.800	0.91
302_I	331_A	0.799	0.91
89_K	93_N	0.788	0.91
125_T	128_N	0.787	0.91
78_A	81_I	0.787	0.91
297_N	325_T	0.783	0.90
86_D	97_I	0.780	0.90
72_V	76_D	0.779	0.90
58_L	61_S	0.777	0.90
123_R	126_I	0.776	0.90
277_S	313_A	0.776	0.90
148_H	177_I	0.776	0.90
54_T	62_L	0.775	0.90
375_T	380_I	0.774	0.90
214_M	232_T	0.772	0.90
224_K	251_S	0.771	0.90
118_Y	148_H	0.769	0.90
362_I	365_G	0.762	0.89
71_E	78_A	0.761	0.89
286_R	320_M	0.758	0.89
192_F	204_S	0.757	0.89
257_V	306_S	0.755	0.89
321_L	331_A	0.754	0.89
33_F	120_L	0.754	0.89
158_Q	189_D	0.751	0.88
249_T	279_D	0.749	0.88
150_I	181_N	0.745	0.88
331_A	334_S	0.741	0.88
129_E	132_Y	0.739	0.88
93_N	98_D	0.738	0.88
29_R	33_F	0.737	0.88
161_V	188_L	0.737	0.88
305_R	336_A	0.733	0.87
192_F	196_S	0.732	0.87
71_E	76_D	0.732	0.87
279_D	310_G	0.731	0.87
33_F	36_Y	0.731	0.87
41_Y	51_K	0.730	0.87
32_A	35_L	0.729	0.87
192_F	202_L	0.727	0.87
82_E	93_N	0.726	0.87
102_N	106_I	0.723	0.87
255_D	286_R	0.722	0.86
28_E	32_A	0.722	0.86
248_G	277_S	0.722	0.86
288_V	322_E	0.721	0.86
80_V	124_I	0.720	0.86
353_L	361_I	0.716	0.86
376_L	379_R	0.713	0.86
73_K	77_T	0.712	0.86
307_L	314_K	0.711	0.86
56_W	59_Y	0.710	0.86
163_Y	166_L	0.710	0.86
181_N	209_N	0.708	0.85
194_N	223_N	0.708	0.85
44_I	55_E	0.707	0.85
243_S	373_P	0.705	0.85
189_D	217_S	0.700	0.85
320_M	332_K	0.700	0.85
77_T	80_V	0.700	0.85
302_I	321_L	0.699	0.85
253_K	282_F	0.699	0.85
259_N	290_T	0.698	0.85
54_T	64_L	0.697	0.84
237_S	264_G	0.695	0.84
144_F	173_L	0.694	0.84
89_K	96_Q	0.693	0.84
229_Q	286_R	0.689	0.84
71_E	77_T	0.688	0.84
53_Y	56_W	0.687	0.84
109_D	117_A	0.687	0.84
22_F	26_K	0.686	0.84
109_D	114_V	0.685	0.83
280_Q	310_G	0.685	0.83
194_N	220_V	0.684	0.83
93_N	100_L	0.682	0.83
206_I	228_V	0.678	0.83
107_S	110_E	0.676	0.83
125_T	129_E	0.676	0.83
72_V	78_A	0.674	0.82
210_I	240_S	0.674	0.82
59_Y	62_L	0.673	0.82
215_H	241_E	0.672	0.82
118_Y	177_I	0.670	0.82
320_M	324_K	0.670	0.82
94_D	97_I	0.669	0.82
129_E	136_H	0.668	0.82
211_K	236_E	0.668	0.82
271_G	289_A	0.667	0.82
293_E	296_I	0.667	0.82
309_L	346_F	0.666	0.82
56_W	63_N	0.665	0.82
79_N	126_I	0.664	0.82
52_H	58_L	0.663	0.81
310_G	313_A	0.661	0.81
35_L	40_P	0.659	0.81
123_R	185_N	0.658	0.81
191_Q	375_T	0.658	0.81
231_S	261_I	0.657	0.81
186_S	212_G	0.657	0.81
274_K	369_E	0.655	0.81
234_L	338_S	0.655	0.81
52_H	55_E	0.653	0.80
142_K	171_S	0.652	0.80
172_S	196_S	0.650	0.80
96_Q	99_D	0.650	0.80
79_N	84_I	0.650	0.80
170_E	199_N	0.650	0.80
195_F	382_E	0.649	0.80
220_V	256_V	0.649	0.80
103_D	117_A	0.647	0.80
228_V	273_M	0.643	0.79
57_D	61_S	0.643	0.79
378_D	381_E	0.642	0.79
81_I	86_D	0.640	0.79
56_W	64_L	0.640	0.79
39_K	46_D	0.639	0.79
292_D	325_T	0.638	0.79
61_S	65_T	0.635	0.79
184_D	237_S	0.634	0.78
297_N	326_G	0.634	0.78
258_N	271_G	0.632	0.78
69_R	77_T	0.632	0.78
325_T	334_S	0.632	0.78
102_N	121_S	0.631	0.78
263_L	294_T	0.630	0.78
257_V	367_I	0.630	0.78
210_I	238_S	0.628	0.78
54_T	57_D	0.628	0.78
125_T	156_D	0.628	0.78
234_L	263_L	0.625	0.77
323_V	331_A	0.625	0.77
246_A	256_V	0.625	0.77
157_K	188_L	0.623	0.77
287_G	322_E	0.623	0.77
40_P	112_K	0.622	0.77
257_V	304_G	0.621	0.77
325_T	331_A	0.620	0.77
79_N	83_I	0.619	0.77
247_F	278_N	0.617	0.77
348_L	362_I	0.613	0.76
188_L	214_M	0.612	0.76
201_L	224_K	0.611	0.76
147_S	174_I	0.611	0.76
228_V	256_V	0.610	0.76
64_L	173_L	0.609	0.76
112_K	118_Y	0.607	0.75
69_R	73_K	0.605	0.75
102_N	105_I	0.604	0.75
271_G	298_S	0.604	0.75
277_S	283_T	0.604	0.75
276_I	307_L	0.603	0.75
348_L	353_L	0.599	0.74
280_Q	313_A	0.599	0.74
165_V	174_I	0.598	0.74
100_L	150_I	0.598	0.74
70_Q	73_K	0.597	0.74
298_S	325_T	0.597	0.74
336_A	350_T	0.596	0.74
136_H	145_S	0.596	0.74
35_L	108_S	0.595	0.74
242_F	260_V	0.594	0.74
206_I	230_F	0.593	0.74
111_H	114_V	0.590	0.73
41_Y	44_I	0.589	0.73
353_L	358_A	0.587	0.73
272_F	373_P	0.587	0.73
167_N	170_E	0.586	0.73
338_S	341_D	0.585	0.73
293_E	312_D	0.585	0.73
272_F	370_E	0.585	0.73
53_Y	58_L	0.584	0.73
29_R	36_Y	0.582	0.72
323_V	328_V	0.582	0.72
285_V	288_V	0.580	0.72
158_Q	185_N	0.580	0.72
174_I	196_S	0.580	0.72
255_D	285_V	0.579	0.72
249_T	278_N	0.576	0.72
36_Y	39_K	0.575	0.71
75_N	78_A	0.575	0.71
205_Y	229_Q	0.571	0.71
220_V	254_I	0.570	0.71
108_S	114_V	0.569	0.71
364_R	368_I	0.569	0.71
54_T	61_S	0.569	0.71
83_I	88_I	0.569	0.71
165_V	202_L	0.567	0.70
265_Q	271_G	0.565	0.70
285_V	328_V	0.564	0.70
213_T	241_E	0.564	0.70
207_K	233_R	0.563	0.70
273_M	304_G	0.562	0.70
264_G	294_T	0.560	0.69
306_S	315_A	0.555	0.69
274_K	303_I	0.555	0.69
273_M	306_S	0.554	0.69
68_S	73_K	0.554	0.69
176_P	204_S	0.553	0.69
296_I	336_A	0.553	0.69
204_S	218_I	0.552	0.68
54_T	284_V	0.551	0.68
54_T	59_Y	0.551	0.68
235_E	264_G	0.550	0.68
272_F	303_I	0.549	0.68
45_H	49_T	0.548	0.68
222_G	252_N	0.548	0.68
86_D	121_S	0.546	0.68
260_V	271_G	0.546	0.68
96_Q	100_L	0.546	0.68
215_H	375_T	0.546	0.68
178_I	190_F	0.546	0.68
300_T	304_G	0.545	0.67
54_T	58_L	0.545	0.67
91_P	94_D	0.544	0.67
275_A	304_G	0.543	0.67
36_Y	46_D	0.543	0.67
292_D	324_K	0.543	0.67
244_S	256_V	0.542	0.67
110_E	114_V	0.542	0.67
84_I	93_N	0.541	0.67
295_A	325_T	0.540	0.67
117_A	175_T	0.540	0.67
113_L	119_S	0.539	0.67
41_Y	113_L	0.539	0.67
291_I	299_S	0.538	0.66
180_V	208_A	0.537	0.66
189_D	375_T	0.537	0.66
289_A	308_V	0.536	0.66
294_T	297_N	0.536	0.66
184_D	236_E	0.536	0.66
192_F	218_I	0.535	0.66
214_M	240_S	0.534	0.66
77_T	81_I	0.533	0.66
198_D	250_H	0.532	0.66
288_V	302_I	0.531	0.65
73_K	76_D	0.530	0.65
161_V	178_I	0.529	0.65
228_V	240_S	0.528	0.65
158_Q	213_T	0.528	0.65
291_I	328_V	0.528	0.65
202_L	226_G	0.527	0.65
238_S	265_Q	0.527	0.65
322_E	325_T	0.527	0.65
175_T	203_F	0.526	0.65
271_G	302_I	0.526	0.65
157_K	186_S	0.525	0.65
318_S	332_K	0.525	0.65
90_I	93_N	0.525	0.65
272_F	369_E	0.524	0.64
134_V	163_Y	0.524	0.64
255_D	331_A	0.523	0.64
232_T	338_S	0.523	0.64
132_Y	136_H	0.522	0.64
178_I	217_S	0.522	0.64
116_L	146_P	0.520	0.64
335_A	363_I	0.519	0.64
282_F	313_A	0.518	0.64
131_E	337_V	0.516	0.63
137_V	140_K	0.516	0.63
40_P	43_L	0.515	0.63
117_A	121_S	0.514	0.63
165_V	192_F	0.514	0.63
291_I	318_S	0.514	0.63
291_I	322_E	0.512	0.63
295_A	331_A	0.512	0.63
103_D	115_S	0.512	0.63
87_T	141_D	0.511	0.62
90_I	94_D	0.510	0.62
336_A	370_E	0.510	0.62
41_Y	56_W	0.509	0.62
327_R	331_A	0.508	0.62
334_S	362_I	0.508	0.62
269_S	289_A	0.507	0.62
107_S	141_D	0.507	0.62
90_I	97_I	0.506	0.62
237_S	268_V	0.506	0.62
332_K	338_S	0.505	0.62
304_G	334_S	0.504	0.61
236_E	297_N	0.504	0.61
219_F	371_Q	0.503	0.61
29_R	32_A	0.503	0.61
51_K	227_H	0.503	0.61
104_S	179_S	0.502	0.61
114_V	117_A	0.500	0.61
219_F	245_R	0.500	0.61

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1vh4A	2	0.946	100	0.183	Contact Map
4dn7A	2	0.9563	100	0.289	Contact Map
1yzyA	1	0.1774	29.2	0.968	Contact Map
1vegA	1	0.1979	27.6	0.969	Contact Map
3dqqA	2	0.1877	27.3	0.969	Contact Map
4k6mA	2	0.1362	26.6	0.969	Contact Map
4edgA	1	0.1928	25.8	0.969	Contact Map
1wjiA	1	0.1285	22.7	0.97	Contact Map
4ae4A	2	0.1414	20.4	0.97	Contact Map
2dakA	1	0.1285	19.7	0.971	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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