GREMLIN Database
Q97ZI0 - Uncharacterized protein
UniProt: Q97ZI0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 389 (355)
Sequences: 3838 (2270)
Seq/√Len: 120.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
125_T158_Q4.6311.00
153_V157_K4.6021.00
354_S357_E4.3121.00
155_N184_D4.1981.00
158_Q187_S4.1361.00
182_I186_S3.8861.00
153_V188_L3.8601.00
185_N211_K3.7121.00
246_A275_A3.5341.00
155_N183_E3.3101.00
156_D185_N3.2971.00
182_I214_M3.2881.00
248_G281_A3.2661.00
208_A214_M3.1751.00
211_K237_S3.0091.00
187_S213_T3.0081.00
355_R359_E2.9611.00
261_I292_D2.9231.00
236_E266_K2.8781.00
266_K297_N2.8721.00
182_I212_G2.8631.00
159_I188_L2.6861.00
85_D88_I2.6751.00
153_V186_S2.5921.00
262_H269_S2.4361.00
236_E265_Q2.3971.00
209_N235_E2.3561.00
123_R127_N2.3191.00
297_N327_R2.2971.00
213_T239_V2.2811.00
80_V86_D2.2611.00
123_R156_D2.2401.00
180_V188_L2.2271.00
117_A148_H2.2211.00
99_D183_E2.2101.00
270_N299_S2.1761.00
296_I325_T2.1021.00
282_F316_V2.0901.00
282_F314_K2.0571.00
23_T27_G2.0541.00
317_V335_A2.0031.00
234_L267_S2.0001.00
239_V268_V1.9721.00
131_E164_E1.9521.00
235_E263_L1.9381.00
74_Y78_A1.9241.00
349_Q355_R1.9001.00
182_I188_L1.8921.00
34_S38_S1.8641.00
236_E264_G1.8541.00
301_S332_K1.8171.00
153_V159_I1.7951.00
280_Q312_D1.7931.00
283_T315_A1.7421.00
51_K54_T1.7291.00
248_G254_I1.7171.00
32_A118_Y1.7101.00
172_S200_S1.7011.00
182_I210_I1.6991.00
130_G159_I1.6481.00
277_S281_A1.6381.00
223_N226_G1.6341.00
105_I181_N1.5291.00
233_R261_I1.5201.00
28_E118_Y1.5141.00
232_T240_S1.4861.00
160_K189_D1.4851.00
251_S280_Q1.4831.00
237_S266_K1.4831.00
209_N233_R1.4831.00
33_F37_L1.4821.00
83_I86_D1.4581.00
296_I327_R1.4561.00
94_D98_D1.4461.00
160_K191_Q1.4371.00
264_G267_S1.4371.00
151_I161_V1.4301.00
103_D179_S1.4271.00
291_I331_A1.4221.00
126_I159_I1.4091.00
27_G31_K1.3851.00
74_Y77_T1.3771.00
35_L38_S1.3771.00
263_L292_D1.3721.00
25_D90_I1.3701.00
233_R263_L1.3691.00
124_I127_N1.3641.00
55_E58_L1.3331.00
244_S273_M1.3281.00
238_S267_S1.3281.00
152_N183_E1.3211.00
31_K34_S1.3151.00
294_T325_T1.3081.00
26_K30_E1.3061.00
184_D211_K1.3021.00
276_I367_I1.2861.00
54_T225_M1.2851.00
189_D215_H1.2851.00
82_E85_D1.2821.00
238_S264_G1.2811.00
148_H179_S1.2701.00
153_V182_I1.2701.00
190_F214_M1.2620.99
250_H279_D1.2510.99
72_V77_T1.2420.99
277_S315_A1.2390.99
152_N181_N1.2320.99
151_I180_V1.2290.99
340_I362_I1.2290.99
299_S329_V1.2260.99
304_G317_V1.2240.99
232_T242_F1.2110.99
234_L264_G1.2030.99
123_R128_N1.1980.99
23_T26_K1.1820.99
34_S37_L1.1800.99
80_V85_D1.1790.99
289_A300_T1.1660.99
84_I92_K1.1640.99
268_V299_S1.1640.99
179_S207_K1.1630.99
69_R72_V1.1580.99
163_Y167_N1.1530.99
82_E86_D1.1510.99
253_K284_V1.1340.99
106_I177_I1.1310.99
80_V84_I1.1240.99
185_N237_S1.1210.99
88_I92_K1.1200.99
109_D112_K1.1000.99
49_T53_Y1.1000.99
35_L39_K1.0970.99
155_N185_N1.0940.99
54_T253_K1.0930.99
93_N96_Q1.0780.98
245_R367_I1.0730.98
31_K35_L1.0670.98
298_S328_V1.0640.98
28_E31_K1.0620.98
56_W113_L1.0610.98
291_I298_S1.0600.98
146_P175_T1.0560.98
49_T52_H1.0560.98
241_E270_N1.0550.98
295_A298_S1.0400.98
89_K97_I1.0390.98
100_L152_N1.0390.98
225_M253_K1.0370.98
49_T54_T1.0290.98
70_Q74_Y1.0280.98
289_A298_S1.0280.98
290_T324_K1.0260.98
134_V165_V1.0170.98
149_L178_I1.0170.98
286_R318_S1.0150.98
71_E74_Y1.0150.98
24_Q98_D1.0130.98
135_K166_L1.0090.98
267_S298_S1.0080.98
317_V337_V1.0080.98
123_R129_E1.0070.98
30_E34_S1.0060.97
100_L181_N0.9930.97
374_E380_I0.9850.97
329_V332_K0.9820.97
43_L46_D0.9810.97
171_S199_N0.9810.97
84_I88_I0.9810.97
377_K380_I0.9780.97
124_I129_E0.9770.97
249_T252_N0.9750.97
27_G30_E0.9730.97
163_Y190_F0.9720.97
68_S72_V0.9640.97
116_L120_L0.9520.97
111_H117_A0.9520.97
210_I232_T0.9470.96
184_D238_S0.9450.96
234_L238_S0.9440.96
123_R155_N0.9410.96
112_K117_A0.9390.96
377_K381_E0.9340.96
68_S71_E0.9330.96
112_K115_S0.9320.96
248_G283_T0.9300.96
278_N310_G0.9290.96
79_N86_D0.9290.96
79_N127_N0.9280.96
190_F216_S0.9280.96
58_L224_K0.9270.96
117_A177_I0.9230.96
36_Y112_K0.9220.96
184_D212_G0.9210.96
154_P183_E0.9200.96
196_S202_L0.9180.96
111_H229_Q0.9130.96
328_V331_A0.9130.96
265_Q295_A0.9120.96
84_I89_K0.9090.95
106_I109_D0.9070.95
260_V269_S0.9040.95
291_I302_I0.9020.95
208_A232_T0.9010.95
194_N222_G0.9000.95
290_T322_E0.8990.95
284_V318_S0.8980.95
207_K231_S0.8950.95
164_E382_E0.8930.95
284_V287_G0.8930.95
164_E195_F0.8870.95
25_D121_S0.8850.95
217_S243_S0.8810.95
51_K59_Y0.8740.94
306_S317_V0.8700.94
205_Y231_S0.8700.94
261_I290_T0.8690.94
81_I84_I0.8680.94
81_I124_I0.8670.94
288_V320_M0.8650.94
266_K296_I0.8630.94
80_V83_I0.8610.94
229_Q257_V0.8600.94
56_W61_S0.8590.94
293_E324_K0.8520.94
300_T331_A0.8510.94
256_V273_M0.8490.93
180_V190_F0.8470.93
257_V286_R0.8440.93
137_V166_L0.8430.93
62_L65_T0.8420.93
291_I323_V0.8390.93
180_V214_M0.8390.93
134_V149_L0.8320.93
147_S176_P0.8280.93
210_I214_M0.8270.93
163_Y192_F0.8260.93
104_S181_N0.8240.92
86_D90_I0.8230.92
307_L363_I0.8200.92
111_H118_Y0.8190.92
325_T328_V0.8170.92
265_Q296_I0.8150.92
140_K143_Y0.8130.92
116_L119_S0.8080.92
368_I372_D0.8050.92
222_G226_G0.8040.91
102_N150_I0.8000.91
302_I331_A0.7990.91
89_K93_N0.7880.91
125_T128_N0.7870.91
78_A81_I0.7870.91
297_N325_T0.7830.90
86_D97_I0.7800.90
72_V76_D0.7790.90
58_L61_S0.7770.90
123_R126_I0.7760.90
277_S313_A0.7760.90
148_H177_I0.7760.90
54_T62_L0.7750.90
375_T380_I0.7740.90
214_M232_T0.7720.90
224_K251_S0.7710.90
118_Y148_H0.7690.90
362_I365_G0.7620.89
71_E78_A0.7610.89
286_R320_M0.7580.89
192_F204_S0.7570.89
257_V306_S0.7550.89
321_L331_A0.7540.89
33_F120_L0.7540.89
158_Q189_D0.7510.88
249_T279_D0.7490.88
150_I181_N0.7450.88
331_A334_S0.7410.88
129_E132_Y0.7390.88
93_N98_D0.7380.88
29_R33_F0.7370.88
161_V188_L0.7370.88
305_R336_A0.7330.87
192_F196_S0.7320.87
71_E76_D0.7320.87
279_D310_G0.7310.87
33_F36_Y0.7310.87
41_Y51_K0.7300.87
32_A35_L0.7290.87
192_F202_L0.7270.87
82_E93_N0.7260.87
102_N106_I0.7230.87
255_D286_R0.7220.86
28_E32_A0.7220.86
248_G277_S0.7220.86
288_V322_E0.7210.86
80_V124_I0.7200.86
353_L361_I0.7160.86
376_L379_R0.7130.86
73_K77_T0.7120.86
307_L314_K0.7110.86
56_W59_Y0.7100.86
163_Y166_L0.7100.86
181_N209_N0.7080.85
194_N223_N0.7080.85
44_I55_E0.7070.85
243_S373_P0.7050.85
189_D217_S0.7000.85
320_M332_K0.7000.85
77_T80_V0.7000.85
302_I321_L0.6990.85
253_K282_F0.6990.85
259_N290_T0.6980.85
54_T64_L0.6970.84
237_S264_G0.6950.84
144_F173_L0.6940.84
89_K96_Q0.6930.84
229_Q286_R0.6890.84
71_E77_T0.6880.84
53_Y56_W0.6870.84
109_D117_A0.6870.84
22_F26_K0.6860.84
109_D114_V0.6850.83
280_Q310_G0.6850.83
194_N220_V0.6840.83
93_N100_L0.6820.83
206_I228_V0.6780.83
107_S110_E0.6760.83
125_T129_E0.6760.83
72_V78_A0.6740.82
210_I240_S0.6740.82
59_Y62_L0.6730.82
215_H241_E0.6720.82
118_Y177_I0.6700.82
320_M324_K0.6700.82
94_D97_I0.6690.82
129_E136_H0.6680.82
211_K236_E0.6680.82
271_G289_A0.6670.82
293_E296_I0.6670.82
309_L346_F0.6660.82
56_W63_N0.6650.82
79_N126_I0.6640.82
52_H58_L0.6630.81
310_G313_A0.6610.81
35_L40_P0.6590.81
123_R185_N0.6580.81
191_Q375_T0.6580.81
231_S261_I0.6570.81
186_S212_G0.6570.81
274_K369_E0.6550.81
234_L338_S0.6550.81
52_H55_E0.6530.80
142_K171_S0.6520.80
172_S196_S0.6500.80
96_Q99_D0.6500.80
79_N84_I0.6500.80
170_E199_N0.6500.80
195_F382_E0.6490.80
220_V256_V0.6490.80
103_D117_A0.6470.80
228_V273_M0.6430.79
57_D61_S0.6430.79
378_D381_E0.6420.79
81_I86_D0.6400.79
56_W64_L0.6400.79
39_K46_D0.6390.79
292_D325_T0.6380.79
61_S65_T0.6350.79
184_D237_S0.6340.78
297_N326_G0.6340.78
258_N271_G0.6320.78
69_R77_T0.6320.78
325_T334_S0.6320.78
102_N121_S0.6310.78
263_L294_T0.6300.78
257_V367_I0.6300.78
210_I238_S0.6280.78
54_T57_D0.6280.78
125_T156_D0.6280.78
234_L263_L0.6250.77
323_V331_A0.6250.77
246_A256_V0.6250.77
157_K188_L0.6230.77
287_G322_E0.6230.77
40_P112_K0.6220.77
257_V304_G0.6210.77
325_T331_A0.6200.77
79_N83_I0.6190.77
247_F278_N0.6170.77
348_L362_I0.6130.76
188_L214_M0.6120.76
201_L224_K0.6110.76
147_S174_I0.6110.76
228_V256_V0.6100.76
64_L173_L0.6090.76
112_K118_Y0.6070.75
69_R73_K0.6050.75
102_N105_I0.6040.75
271_G298_S0.6040.75
277_S283_T0.6040.75
276_I307_L0.6030.75
348_L353_L0.5990.74
280_Q313_A0.5990.74
165_V174_I0.5980.74
100_L150_I0.5980.74
70_Q73_K0.5970.74
298_S325_T0.5970.74
336_A350_T0.5960.74
136_H145_S0.5960.74
35_L108_S0.5950.74
242_F260_V0.5940.74
206_I230_F0.5930.74
111_H114_V0.5900.73
41_Y44_I0.5890.73
353_L358_A0.5870.73
272_F373_P0.5870.73
167_N170_E0.5860.73
338_S341_D0.5850.73
293_E312_D0.5850.73
272_F370_E0.5850.73
53_Y58_L0.5840.73
29_R36_Y0.5820.72
323_V328_V0.5820.72
285_V288_V0.5800.72
158_Q185_N0.5800.72
174_I196_S0.5800.72
255_D285_V0.5790.72
249_T278_N0.5760.72
36_Y39_K0.5750.71
75_N78_A0.5750.71
205_Y229_Q0.5710.71
220_V254_I0.5700.71
108_S114_V0.5690.71
364_R368_I0.5690.71
54_T61_S0.5690.71
83_I88_I0.5690.71
165_V202_L0.5670.70
265_Q271_G0.5650.70
285_V328_V0.5640.70
213_T241_E0.5640.70
207_K233_R0.5630.70
273_M304_G0.5620.70
264_G294_T0.5600.69
306_S315_A0.5550.69
274_K303_I0.5550.69
273_M306_S0.5540.69
68_S73_K0.5540.69
176_P204_S0.5530.69
296_I336_A0.5530.69
204_S218_I0.5520.68
54_T284_V0.5510.68
54_T59_Y0.5510.68
235_E264_G0.5500.68
272_F303_I0.5490.68
45_H49_T0.5480.68
222_G252_N0.5480.68
86_D121_S0.5460.68
260_V271_G0.5460.68
96_Q100_L0.5460.68
215_H375_T0.5460.68
178_I190_F0.5460.68
300_T304_G0.5450.67
54_T58_L0.5450.67
91_P94_D0.5440.67
275_A304_G0.5430.67
36_Y46_D0.5430.67
292_D324_K0.5430.67
244_S256_V0.5420.67
110_E114_V0.5420.67
84_I93_N0.5410.67
295_A325_T0.5400.67
117_A175_T0.5400.67
113_L119_S0.5390.67
41_Y113_L0.5390.67
291_I299_S0.5380.66
180_V208_A0.5370.66
189_D375_T0.5370.66
289_A308_V0.5360.66
294_T297_N0.5360.66
184_D236_E0.5360.66
192_F218_I0.5350.66
214_M240_S0.5340.66
77_T81_I0.5330.66
198_D250_H0.5320.66
288_V302_I0.5310.65
73_K76_D0.5300.65
161_V178_I0.5290.65
228_V240_S0.5280.65
158_Q213_T0.5280.65
291_I328_V0.5280.65
202_L226_G0.5270.65
238_S265_Q0.5270.65
322_E325_T0.5270.65
175_T203_F0.5260.65
271_G302_I0.5260.65
157_K186_S0.5250.65
318_S332_K0.5250.65
90_I93_N0.5250.65
272_F369_E0.5240.64
134_V163_Y0.5240.64
255_D331_A0.5230.64
232_T338_S0.5230.64
132_Y136_H0.5220.64
178_I217_S0.5220.64
116_L146_P0.5200.64
335_A363_I0.5190.64
282_F313_A0.5180.64
131_E337_V0.5160.63
137_V140_K0.5160.63
40_P43_L0.5150.63
117_A121_S0.5140.63
165_V192_F0.5140.63
291_I318_S0.5140.63
291_I322_E0.5120.63
295_A331_A0.5120.63
103_D115_S0.5120.63
87_T141_D0.5110.62
90_I94_D0.5100.62
336_A370_E0.5100.62
41_Y56_W0.5090.62
327_R331_A0.5080.62
334_S362_I0.5080.62
269_S289_A0.5070.62
107_S141_D0.5070.62
90_I97_I0.5060.62
237_S268_V0.5060.62
332_K338_S0.5050.62
304_G334_S0.5040.61
236_E297_N0.5040.61
219_F371_Q0.5030.61
29_R32_A0.5030.61
51_K227_H0.5030.61
104_S179_S0.5020.61
114_V117_A0.5000.61
219_F245_R0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vh4A 2 0.946 100 0.183 Contact Map
4dn7A 2 0.9563 100 0.289 Contact Map
1yzyA 1 0.1774 29.2 0.968 Contact Map
1vegA 1 0.1979 27.6 0.969 Contact Map
3dqqA 2 0.1877 27.3 0.969 Contact Map
4k6mA 2 0.1362 26.6 0.969 Contact Map
4edgA 1 0.1928 25.8 0.969 Contact Map
1wjiA 1 0.1285 22.7 0.97 Contact Map
4ae4A 2 0.1414 20.4 0.97 Contact Map
2dakA 1 0.1285 19.7 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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