GREMLIN Database
Q97ZH8 - Uncharacterized protein
UniProt: Q97ZH8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 122 (100)
Sequences: 112 (94)
Seq/√Len: 9.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_I37_A3.0190.92
7_C93_C2.7680.88
93_C96_C2.7000.86
31_N84_S2.3620.77
43_L46_A2.3520.77
19_R47_A2.3310.76
80_R91_Y2.3150.76
26_L40_L2.3000.75
8_E44_T2.1510.70
18_V55_R2.1490.70
40_L81_I2.1430.70
14_I36_K2.1080.69
38_A46_A2.0820.68
41_M53_K2.0090.65
23_A47_A1.9450.62
8_E46_A1.9020.60
15_L54_S1.8360.57
8_E59_N1.5190.43
38_A43_L1.4890.42
68_E75_N1.4830.42
7_C96_C1.4760.42
11_V34_E1.4400.40
92_Y95_L1.4020.38
47_A50_N1.3780.37
68_E79_E1.3540.36
22_V74_V1.3440.36
72_D79_E1.3140.35
21_I78_T1.2890.34
47_A57_G1.2810.34
45_P54_S1.2440.32
35_Y44_T1.2290.31
20_S41_M1.2240.31
10_S95_L1.2220.31
6_P45_P1.2130.31
91_Y94_I1.2080.31
24_Q54_S1.1880.30
43_L48_V1.1680.29
28_K82_L1.1640.29
41_M81_I1.1620.29
67_D70_F1.1400.28
38_A99_G1.1360.28
68_E105_K1.1340.28
3_L9_F1.1270.28
27_I45_P1.1010.27
19_R50_N1.0850.26
79_E83_N1.0250.24
46_A58_S1.0150.24
22_V53_K1.0090.24
15_L19_R1.0080.24
11_V50_N1.0050.24
38_A100_K1.0040.24
3_L102_V0.9990.23
50_N95_L0.9970.23
44_T59_N0.9960.23
38_A67_D0.9820.23
33_S53_K0.9820.23
69_K76_E0.9800.23
37_A52_L0.9730.23
86_S92_Y0.9630.22
14_I69_K0.9510.22
7_C31_N0.9310.21
73_L76_E0.9240.21
17_A52_L0.9210.21
23_A99_G0.9160.21
34_E50_N0.9150.21
46_A64_L0.9140.21
10_S46_A0.9130.21
5_L9_F0.9080.21
6_P12_R0.9070.21
7_C10_S0.8990.20
3_L81_I0.8810.20
37_A45_P0.8750.20
33_S92_Y0.8730.20
50_N55_R0.8560.19
68_E74_V0.8510.19
20_S100_K0.8480.19
17_A44_T0.8430.19
12_R95_L0.8400.19
10_S99_G0.8330.19
54_S100_K0.8320.18
72_D86_S0.8260.18
5_L70_F0.8190.18
3_L49_S0.8120.18
23_A57_G0.7990.18
73_L77_V0.7900.17
46_A59_N0.7780.17
8_E18_V0.7630.17
18_V34_E0.7560.17
81_I89_S0.7490.16
12_R50_N0.7420.16
69_K90_V0.7390.16
14_I52_L0.7290.16
67_D71_M0.7090.15
50_N98_E0.7020.15
9_F30_R0.6800.15
19_R57_G0.6770.15
12_R66_K0.6770.15
13_E24_Q0.6740.15
45_P64_L0.6710.15
64_L77_V0.6690.15
72_D76_E0.6570.14
19_R51_Y0.6520.14
24_Q52_L0.6430.14
25_K41_M0.6420.14
17_A59_N0.6380.14
11_V26_L0.6370.14
31_N93_C0.6330.14
5_L33_S0.6290.14
68_E86_S0.6280.14
41_M58_S0.6270.14
90_V101_K0.6260.14
18_V69_K0.6260.14
22_V101_K0.6260.14
3_L55_R0.6150.13
75_N94_I0.6070.13
53_K70_F0.6050.13
53_K66_K0.6030.13
43_L59_N0.5990.13
37_A48_V0.5990.13
4_Q54_S0.5990.13
3_L12_R0.5950.13
33_S36_K0.5780.13
6_P44_T0.5770.13
28_K39_N0.5760.13
54_S58_S0.5760.13
40_L94_I0.5710.12
26_L52_L0.5670.12
65_E83_N0.5660.12
68_E90_V0.5630.12
3_L50_N0.5610.12
34_E103_L0.5600.12
32_L44_T0.5560.12
36_K68_E0.5430.12
11_V48_V0.5430.12
76_E83_N0.5410.12
8_E32_L0.5310.12
65_E71_M0.5290.12
55_R74_V0.5290.12
18_V78_T0.5240.12
7_C15_L0.5240.12
28_K72_D0.5230.12
46_A103_L0.5220.12
12_R73_L0.5090.11
28_K37_A0.5080.11
27_I47_A0.5050.11
37_A42_G0.5050.11
10_S35_Y0.5040.11
95_L103_L0.5030.11
53_K64_L0.5030.11
4_Q95_L0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2cw1A 1 0.4672 97.9 0.815 Contact Map
2pijA 2 0.4918 97.1 0.843 Contact Map
2w7nA 2 0.6721 97 0.844 Contact Map
2xi8A 2 0.541 97 0.844 Contact Map
2ef8A 2 0.6311 96.9 0.846 Contact Map
3bs3A 2 0.5082 96.9 0.846 Contact Map
1r69A 1 0.5164 96.8 0.848 Contact Map
1zugA 1 0.582 96.8 0.849 Contact Map
1zx4A 2 0.8934 96.8 0.849 Contact Map
3eusA 2 0.6639 96.7 0.85 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0059 seconds.