GREMLIN Database
GATD - Glutamyl-tRNA(Gln) amidotransferase subunit D
UniProt: Q97ZH5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 444 (339)
Sequences: 682 (475)
Seq/√Len: 25.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
312_Y337_A7.1021.00
184_T201_L6.3211.00
192_L199_V6.1691.00
188_L201_L4.2041.00
413_D416_K4.0151.00
98_S104_V3.9711.00
233_E274_L3.6781.00
236_V255_V3.6721.00
353_R357_K3.6641.00
233_E251_R3.6631.00
260_S366_T3.5291.00
250_H255_V3.4861.00
113_A116_P3.2481.00
363_G392_L3.2081.00
323_E354_K3.1711.00
141_L160_S3.1351.00
305_D332_R2.9791.00
161_V188_L2.9611.00
363_G421_M2.7861.00
407_V420_L2.7640.99
189_A253_V2.7190.99
97_I141_L2.6490.99
165_F197_G2.5810.99
173_V226_A2.4770.99
361_F390_T2.4220.99
93_E135_K2.4060.99
414_L418_Q2.3060.98
364_M389_V2.2980.98
204_S260_S2.2680.98
338_G364_M2.2670.98
337_A397_P2.2430.98
407_V411_E2.2360.98
326_L360_I2.1920.97
249_V275_A2.1910.97
323_E351_L2.1560.97
416_K419_N2.0760.96
333_G400_A2.0650.96
94_I291_Y2.0410.96
326_L355_A2.0410.96
237_N249_V2.0320.96
225_T237_N2.0250.96
363_G404_L2.0210.96
333_G404_L1.9790.95
103_I215_S1.9180.94
311_L322_L1.8900.94
310_L397_P1.8220.92
159_E302_A1.8010.92
361_F417_I1.7870.92
270_N394_D1.7510.91
361_F414_L1.7100.90
173_V223_V1.6980.89
231_F284_L1.6820.89
162_K300_L1.6560.88
144_I149_M1.6460.88
144_I153_F1.6450.88
182_A398_E1.5950.86
201_L252_G1.5880.86
94_I418_Q1.5620.85
237_N277_V1.5600.85
155_V191_S1.5340.84
114_V207_S1.5310.84
196_Q298_T1.4630.81
193_R301_D1.4430.80
200_V235_V1.4380.80
158_A300_L1.4360.80
123_I140_V1.4350.79
201_L274_L1.4100.78
225_T249_V1.4030.78
406_W410_H1.3980.78
254_K315_P1.3940.77
137_D168_G1.3930.77
185_A400_A1.3900.77
165_F172_I1.3850.77
195_L199_V1.3840.77
254_K430_N1.3790.77
97_I226_A1.3780.77
206_R212_S1.3660.76
335_I363_G1.3600.76
365_T397_P1.3530.75
399_V402_V1.3500.75
412_Q416_K1.3480.75
251_R274_L1.3300.74
168_G197_G1.3200.73
130_I141_L1.3080.73
417_I421_M1.3010.72
109_Y114_V1.2940.72
359_G418_Q1.2800.71
151_P316_G1.2680.70
213_S216_A1.2670.70
176_H184_T1.2560.70
152_E306_N1.2290.68
366_T372_R1.2190.67
364_M384_L1.2170.67
206_R263_R1.2160.67
265_A405_M1.2110.67
161_V174_I1.2060.66
185_A255_V1.1970.66
130_I171_G1.1940.66
313_Y345_S1.1920.65
257_K340_G1.1900.65
393_E429_I1.1790.65
114_V117_A1.1780.64
144_I339_T1.1770.64
159_E300_L1.1760.64
181_M236_V1.1760.64
193_R299_L1.1700.64
152_E419_N1.1650.64
163_K386_D1.1530.63
256_R259_H1.1530.63
407_V417_I1.1450.62
348_H357_K1.1370.62
106_R116_P1.1350.62
160_S163_K1.1210.61
240_A248_L1.1210.61
382_R385_L1.1190.60
378_Y381_G1.1120.60
322_L352_F1.1110.60
376_N381_G1.1110.60
103_I204_S1.1100.60
191_S304_F1.1030.59
165_F168_G1.1010.59
92_S134_A1.0950.59
221_S237_N1.0810.58
139_E160_S1.0770.57
385_L406_W1.0620.56
164_A413_D1.0620.56
194_S297_E1.0550.56
384_L389_V1.0530.56
130_I220_L1.0520.56
325_M330_K1.0490.55
375_M381_G1.0450.55
343_H364_M1.0440.55
112_G174_I1.0430.55
209_D259_H1.0420.55
110_E116_P1.0400.55
215_S309_F1.0210.53
200_V249_V1.0190.53
236_V306_N1.0180.53
235_V275_A1.0180.53
95_K164_A1.0060.52
256_R306_N1.0040.52
335_I392_L1.0000.52
94_I227_K0.9960.52
154_W315_P0.9930.51
250_H268_S0.9900.51
150_K222_A0.9850.51
339_T343_H0.9850.51
94_I170_T0.9780.50
186_S402_V0.9770.50
150_K304_F0.9740.50
106_R119_T0.9730.50
149_M184_T0.9710.50
127_L130_I0.9700.50
121_E222_A0.9700.50
213_S274_L0.9680.49
239_H366_T0.9680.49
297_E416_K0.9670.49
148_N380_T0.9660.49
150_K153_F0.9660.49
108_E417_I0.9530.48
332_R409_A0.9530.48
95_K139_E0.9510.48
233_E249_V0.9480.48
147_E343_H0.9430.48
162_K166_D0.9390.47
133_I136_V0.9350.47
322_L348_H0.9320.47
239_H264_D0.9220.46
192_L252_G0.9210.46
289_E413_D0.9210.46
259_H370_F0.9160.46
364_M375_M0.9160.46
161_V172_I0.9140.45
124_I418_Q0.9090.45
378_Y388_G0.9040.45
317_L345_S0.9010.45
235_V274_L0.9000.44
97_I139_E0.8940.44
332_R418_Q0.8900.44
193_R426_V0.8890.44
192_L360_I0.8880.44
147_E238_M0.8870.44
181_M344_T0.8870.44
108_E115_R0.8860.43
111_T210_R0.8830.43
323_E353_R0.8820.43
125_Q222_A0.8820.43
133_I202_V0.8780.43
268_S394_D0.8730.43
101_G177_G0.8730.43
100_G266_F0.8720.42
96_I141_L0.8700.42
361_F407_V0.8680.42
404_L421_M0.8660.42
230_P360_I0.8660.42
159_E162_K0.8650.42
334_I355_A0.8640.42
254_K394_D0.8630.42
212_S338_G0.8600.42
183_Y367_Q0.8570.41
333_G365_T0.8550.41
256_R263_R0.8530.41
324_Q329_T0.8520.41
190_F428_E0.8480.41
204_S261_S0.8460.41
256_R397_P0.8430.40
210_R239_H0.8400.40
294_K298_T0.8400.40
331_I417_I0.8390.40
212_S279_W0.8380.40
136_V204_S0.8350.40
284_L418_Q0.8330.40
170_T197_G0.8320.40
236_V250_H0.8290.39
165_F194_S0.8290.39
181_M222_A0.8270.39
188_L252_G0.8260.39
411_E416_K0.8230.39
171_G198_P0.8220.39
209_D213_S0.8220.39
168_G172_I0.8210.39
331_I390_T0.8200.39
178_T340_G0.8120.38
386_D424_N0.8110.38
356_T387_A0.8110.38
184_T187_A0.8060.38
157_I164_A0.8050.38
351_L354_K0.8050.38
235_V249_V0.8040.38
355_A360_I0.8010.37
154_W388_G0.8010.37
94_I139_E0.8000.37
338_G343_H0.7980.37
200_V302_A0.7910.37
311_L333_G0.7900.37
154_W394_D0.7840.36
186_S253_V0.7800.36
168_G171_G0.7790.36
154_W402_V0.7780.36
129_E216_A0.7770.36
145_L339_T0.7730.36
174_I201_L0.7730.36
98_S148_N0.7650.35
202_V237_N0.7640.35
200_V220_L0.7630.35
150_K395_M0.7620.35
128_P173_V0.7590.35
205_Q263_R0.7590.35
95_K168_G0.7560.34
97_I150_K0.7520.34
200_V415_E0.7520.34
263_R317_L0.7510.34
127_L201_L0.7460.34
176_H203_G0.7460.34
210_R264_D0.7450.34
318_D321_F0.7440.34
96_I407_V0.7440.34
336_I352_F0.7430.34
100_G177_G0.7430.34
406_W426_V0.7400.33
238_M263_R0.7380.33
365_T392_L0.7370.33
207_S239_H0.7340.33
419_N423_T0.7340.33
258_M267_Q0.7270.32
321_F325_M0.7260.32
227_K291_Y0.7260.32
97_I156_K0.7210.32
157_I171_G0.7210.32
367_Q398_E0.7200.32
345_S416_K0.7200.32
367_Q378_Y0.7200.32
97_I174_I0.7190.32
148_N172_I0.7180.32
176_H252_G0.7170.32
305_D311_L0.7150.32
198_P263_R0.7140.32
186_S249_V0.7130.32
133_I227_K0.7120.32
103_I176_H0.7120.32
156_K335_I0.7110.31
224_I228_Y0.7090.31
181_M413_D0.7060.31
84_R359_G0.7060.31
381_G384_L0.7020.31
193_R336_I0.7020.31
378_Y384_L0.7020.31
194_S291_Y0.7020.31
200_V226_A0.7020.31
186_S189_A0.6980.31
172_I199_V0.6960.31
117_A391_P0.6950.30
154_W368_C0.6940.30
235_V331_I0.6940.30
403_K428_E0.6930.30
164_A167_E0.6890.30
159_E352_F0.6870.30
231_F406_W0.6870.30
100_G257_K0.6820.30
124_I138_A0.6820.30
223_V392_L0.6810.30
326_L425_L0.6810.30
111_T222_A0.6800.30
163_K419_N0.6790.29
129_E220_L0.6790.29
316_G344_T0.6780.29
107_V210_R0.6780.29
138_A141_L0.6780.29
364_M373_V0.6770.29
201_L337_A0.6770.29
212_S281_E0.6760.29
174_I355_A0.6750.29
291_Y294_K0.6740.29
174_I359_G0.6730.29
410_H420_L0.6720.29
409_A424_N0.6710.29
129_E211_P0.6700.29
359_G430_N0.6670.29
202_V222_A0.6660.29
162_K302_A0.6640.29
145_L234_V0.6630.28
354_K358_D0.6630.28
154_W252_G0.6620.28
343_H378_Y0.6620.28
224_I405_M0.6610.28
95_K165_F0.6600.28
425_L431_P0.6600.28
155_V303_K0.6590.28
199_V359_G0.6580.28
204_S351_L0.6580.28
149_M256_R0.6570.28
352_F418_Q0.6570.28
120_T212_S0.6540.28
209_D239_H0.6530.28
278_L281_E0.6530.28
140_V153_F0.6510.28
105_S119_T0.6480.28
401_L405_M0.6440.27
195_L425_L0.6430.27
336_I364_M0.6430.27
315_P398_E0.6420.27
171_G404_L0.6410.27
129_E134_A0.6410.27
219_L374_N0.6400.27
162_K192_L0.6390.27
318_D426_V0.6370.27
307_R332_R0.6370.27
254_K403_K0.6370.27
259_H377_V0.6360.27
205_Q378_Y0.6360.27
204_S209_D0.6360.27
205_Q364_M0.6330.27
97_I160_S0.6310.27
323_E420_L0.6290.26
212_S365_T0.6270.26
265_A270_N0.6270.26
149_M157_I0.6270.26
376_N391_P0.6260.26
168_G310_L0.6230.26
99_T266_F0.6230.26
350_E432_R0.6220.26
310_L407_V0.6180.26
184_T255_V0.6180.26
227_K426_V0.6180.26
356_T397_P0.6180.26
125_Q332_R0.6170.26
248_L276_K0.6170.26
206_R240_A0.6170.26
88_N357_K0.6160.26
315_P403_K0.6160.26
94_I134_A0.6160.26
224_I352_F0.6150.26
226_A233_E0.6130.26
213_S286_M0.6120.26
309_F331_I0.6120.26
90_A419_N0.6090.25
154_W387_A0.6080.25
204_S411_E0.6060.25
110_E383_Q0.6040.25
381_G385_L0.6040.25
174_I184_T0.6010.25
285_V288_N0.6000.25
187_A205_Q0.5990.25
363_G417_I0.5990.25
322_L355_A0.5990.25
159_E284_L0.5980.25
214_D257_K0.5970.25
174_I422_I0.5960.25
94_I150_K0.5950.25
222_A338_G0.5920.24
345_S398_E0.5900.24
159_E389_V0.5880.24
139_E220_L0.5860.24
102_T146_S0.5860.24
148_N270_N0.5840.24
153_F157_I0.5830.24
226_A274_L0.5830.24
175_A249_V0.5820.24
207_S263_R0.5820.24
94_I279_W0.5780.24
320_D339_T0.5780.24
311_L331_I0.5750.24
97_I199_V0.5750.24
204_S366_T0.5750.24
166_D416_K0.5750.24
89_G174_I0.5740.23
261_S393_E0.5740.23
202_V238_M0.5720.23
100_G340_G0.5710.23
222_A326_L0.5690.23
404_L417_I0.5680.23
161_V249_V0.5680.23
298_T337_A0.5670.23
177_G266_F0.5670.23
343_H388_G0.5670.23
178_T257_K0.5660.23
105_S172_I0.5660.23
104_V120_T0.5660.23
420_L426_V0.5650.23
157_I230_P0.5640.23
407_V421_M0.5640.23
335_I373_V0.5640.23
379_T383_Q0.5620.23
125_Q292_I0.5610.23
149_M259_H0.5600.23
106_R122_E0.5570.23
153_F156_K0.5560.23
104_V141_L0.5550.22
104_V126_F0.5550.22
206_R239_H0.5530.22
215_S219_L0.5530.22
341_L364_M0.5520.22
130_I353_R0.5480.22
139_E164_A0.5480.22
323_E334_I0.5470.22
357_K413_D0.5470.22
100_G178_T0.5460.22
91_K135_K0.5460.22
201_L397_P0.5460.22
223_V345_S0.5440.22
116_P370_F0.5440.22
137_D167_E0.5440.22
414_L417_I0.5430.22
409_A420_L0.5410.22
217_I221_S0.5400.22
396_L399_V0.5400.22
101_G214_D0.5400.22
313_Y344_T0.5380.22
148_N180_T0.5360.22
170_T249_V0.5360.22
408_L411_E0.5350.21
261_S366_T0.5320.21
182_A399_V0.5320.21
290_K295_K0.5310.21
94_I232_G0.5300.21
368_C398_E0.5280.21
185_A240_A0.5280.21
303_K335_I0.5260.21
159_E350_E0.5250.21
268_S275_A0.5250.21
104_V212_S0.5250.21
269_V389_V0.5250.21
183_Y253_V0.5250.21
415_E419_N0.5240.21
147_E339_T0.5220.21
316_G387_A0.5220.21
267_Q422_I0.5220.21
322_L351_L0.5210.21
182_A363_G0.5210.21
353_R419_N0.5200.21
270_N345_S0.5200.21
145_L252_G0.5200.21
186_S252_G0.5190.21
120_T204_S0.5190.21
199_V290_K0.5190.21
102_T112_G0.5190.21
145_L396_L0.5190.21
257_K266_F0.5190.21
338_G341_L0.5180.21
196_Q362_I0.5170.21
190_F406_W0.5160.21
371_G400_A0.5150.20
367_Q403_K0.5150.20
103_I259_H0.5150.20
163_K199_V0.5150.20
256_R369_L0.5140.20
319_R351_L0.5130.20
366_T393_E0.5130.20
124_I127_L0.5130.20
251_R384_L0.5120.20
174_I271_D0.5090.20
342_G367_Q0.5080.20
161_V170_T0.5080.20
109_Y112_G0.5080.20
138_A285_V0.5080.20
254_K367_Q0.5070.20
280_K322_L0.5060.20
236_V286_M0.5050.20
279_W308_V0.5050.20
332_R411_E0.5040.20
239_H250_H0.5040.20
387_A415_E0.5030.20
312_Y397_P0.5010.20
167_E326_L0.5010.20
146_S266_F0.5010.20
236_V362_I0.5010.20
161_V165_F0.5010.20
86_V89_G0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2d6fA 2 0.9572 100 0.184 Contact Map
1zq1A 2 0.9685 100 0.195 Contact Map
1wlsA 2 0.732 100 0.353 Contact Map
4q0mA 2 0.7297 100 0.353 Contact Map
2himA 4 0.741 100 0.355 Contact Map
4r8kA 3 0.741 100 0.359 Contact Map
2wltA 4 0.7162 100 0.38 Contact Map
1nnsA 4 0.723 100 0.383 Contact Map
1wsaA 4 0.7095 100 0.383 Contact Map
1agxA 4 0.7207 100 0.385 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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