GREMLIN Database
Q97ZH3 - Pre mRNA splicing protein
UniProt: Q97ZH3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 412 (395)
Sequences: 774 (472)
Seq/√Len: 23.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
187_S238_N5.7131.00
148_D276_R5.2121.00
387_Q390_K4.6531.00
373_E377_K4.1961.00
295_I346_A4.1591.00
401_G404_G4.0521.00
391_P394_P4.0481.00
388_Q391_P4.0461.00
374_I377_K3.9411.00
385_K388_Q3.9111.00
364_N368_K3.7791.00
402_K405_G3.7121.00
405_G408_R3.5931.00
258_M274_G3.4911.00
393_Q396_K3.4251.00
404_G407_R3.3781.00
377_K384_K3.3321.00
381_P384_K3.1321.00
187_S241_L3.1241.00
172_L213_I2.9951.00
373_E384_K2.9671.00
386_P389_Q2.9581.00
390_K393_Q2.9541.00
402_K407_R2.9011.00
397_Q400_K2.8981.00
400_K403_K2.8810.99
151_D247_R2.8400.99
374_I384_K2.6720.99
389_Q392_Q2.6380.99
162_R173_D2.4790.98
394_P397_Q2.4760.98
54_L58_V2.4220.98
268_L341_L2.4010.98
189_F200_L2.2330.97
387_Q391_P2.2260.97
200_L213_I2.2140.97
340_A367_L2.2060.97
377_K381_P2.1610.96
255_E271_P2.1240.96
24_D54_L2.0970.95
397_Q401_G2.0610.95
396_K402_K2.0540.95
189_F195_L2.0340.95
373_E376_E2.0260.94
211_N215_D2.0250.94
207_E211_N2.0120.94
330_P333_Q1.9760.94
373_E381_P1.9680.94
13_A17_D1.9480.93
396_K400_K1.9320.93
140_A261_V1.9220.93
401_G408_R1.9160.93
74_L81_V1.9030.92
158_S183_A1.8950.92
351_V359_I1.8800.92
175_L216_A1.7240.88
401_G405_G1.7170.88
5_Y15_A1.7010.87
8_E11_I1.6840.87
238_N241_L1.6630.86
24_D58_V1.6320.85
266_T271_P1.6160.84
151_D275_A1.5980.84
144_V324_P1.5970.84
396_K404_G1.5920.83
362_Q365_E1.5870.83
268_L367_L1.5660.82
7_I17_D1.5420.81
49_S52_V1.5250.81
259_K266_T1.5200.80
290_M346_A1.5040.80
55_L74_L1.4990.79
167_I223_A1.4850.79
368_K371_I1.4820.79
389_Q397_Q1.4750.78
337_I367_L1.4380.77
136_R261_V1.4340.76
28_N35_I1.4250.76
162_R290_M1.4240.76
149_D153_T1.4150.75
374_I381_P1.4060.75
11_I17_D1.3860.74
132_A135_K1.3820.74
219_K251_N1.3770.73
64_V86_Y1.3600.72
63_V74_L1.3600.72
191_D194_F1.3590.72
374_I380_Q1.3520.72
201_K205_F1.3220.70
50_A54_L1.3210.70
389_Q393_Q1.3190.70
376_E381_P1.3060.69
385_K392_Q1.3020.69
268_L345_L1.3010.69
389_Q400_K1.2920.68
308_L342_A1.2890.68
139_L146_A1.2830.68
9_H13_A1.2780.67
392_Q395_Q1.2780.67
194_F197_I1.2690.67
296_Q301_E1.2660.67
53_E61_Q1.2650.67
133_A141_I1.2570.66
403_K406_K1.2560.66
40_L44_K1.2410.65
347_I363_L1.2320.65
132_A138_L1.2150.63
314_P317_H1.2130.63
201_K210_I1.2120.63
185_I200_L1.2070.63
146_A153_T1.2000.62
8_E19_N1.2000.62
237_A310_S1.1990.62
281_A292_A1.1990.62
97_L101_A1.1980.62
390_K395_Q1.1950.62
187_S234_R1.1880.62
148_D322_Q1.1880.62
7_I16_Y1.1810.61
8_E182_Y1.1800.61
329_S371_I1.1730.61
364_N370_R1.1690.60
34_K62_E1.1640.60
149_D218_K1.1630.60
172_L189_F1.1630.60
360_G364_N1.1590.60
59_N84_E1.1460.59
8_E17_D1.1240.57
185_I189_F1.1230.57
109_N295_I1.1200.57
7_I12_G1.1130.57
12_G15_A1.1130.57
6_L9_H1.1120.57
10_V16_Y1.1080.56
209_R212_R1.1060.56
252_N255_E1.1000.56
136_R139_L1.0990.56
364_N371_I1.0950.55
98_P110_E1.0900.55
29_P34_K1.0880.55
34_K50_A1.0880.55
400_K408_R1.0860.55
136_R274_G1.0850.55
386_P392_Q1.0820.54
214_L218_K1.0810.54
69_A74_L1.0810.54
15_A68_E1.0800.54
397_Q405_G1.0750.54
135_K353_A1.0740.54
52_V76_A1.0730.54
73_K256_G1.0650.53
5_Y68_E1.0610.53
32_L37_E1.0590.53
190_G230_L1.0580.53
26_I50_A1.0560.53
121_S158_S1.0560.53
292_A346_A1.0490.52
174_K225_I1.0440.52
180_E245_N1.0390.51
387_Q408_R1.0330.51
376_E384_K1.0270.51
386_P391_P1.0240.50
301_E305_F1.0180.50
303_A306_R1.0170.50
387_Q393_Q1.0090.49
78_G330_P1.0030.49
164_W335_G1.0020.49
393_Q402_K0.9970.48
141_I279_S0.9930.48
122_L317_H0.9910.48
238_N321_F0.9910.48
380_Q383_P0.9880.48
190_G234_R0.9870.48
294_T301_E0.9840.48
205_F213_I0.9810.47
37_E230_L0.9770.47
337_I370_R0.9760.47
130_R274_G0.9730.47
395_Q402_K0.9700.47
301_E316_K0.9630.46
39_L176_I0.9630.46
374_I383_P0.9610.46
122_L314_P0.9590.46
365_E369_K0.9590.46
69_A75_Q0.9570.46
53_E57_K0.9480.45
167_I207_E0.9450.45
167_I264_N0.9420.45
41_N48_F0.9410.44
7_I11_I0.9400.44
230_L237_A0.9380.44
156_L367_L0.9370.44
137_D305_F0.9330.44
237_A324_P0.9330.44
322_Q327_H0.9220.43
261_V338_A0.9220.43
385_K391_P0.9220.43
162_R179_H0.9190.43
305_F309_R0.9180.43
301_E304_L0.9170.43
144_V148_D0.9150.43
137_D293_S0.9150.43
157_F236_I0.9110.42
163_E168_H0.9080.42
10_V19_N0.9080.42
128_K250_L0.9070.42
195_L227_E0.9060.42
11_I15_A0.9030.42
221_I246_I0.9020.42
376_E380_Q0.8990.42
227_E231_S0.8990.42
12_G17_D0.8950.41
160_R303_A0.8920.41
25_Y39_L0.8900.41
8_E237_A0.8900.41
280_I310_S0.8850.41
100_V211_N0.8820.40
190_G194_F0.8820.40
175_L256_G0.8810.40
305_F316_K0.8800.40
333_Q367_L0.8790.40
49_S53_E0.8780.40
47_P52_V0.8740.40
152_K155_N0.8720.40
375_K385_K0.8660.39
17_D85_P0.8660.39
129_L132_A0.8660.39
140_A233_M0.8650.39
9_H19_N0.8630.39
369_K382_P0.8620.39
162_R191_D0.8600.39
14_V65_V0.8590.39
20_G172_L0.8590.39
400_K404_G0.8580.39
68_E362_Q0.8560.39
36_T41_N0.8540.39
309_R317_H0.8520.38
198_D213_I0.8450.38
86_Y90_S0.8450.38
176_I370_R0.8440.38
101_A329_S0.8430.38
293_S301_E0.8430.38
385_K389_Q0.8400.38
132_A139_L0.8390.38
292_A343_A0.8390.38
376_E383_P0.8370.37
123_E139_L0.8370.37
191_D256_G0.8350.37
129_L273_L0.8350.37
186_V264_N0.8330.37
311_G317_H0.8310.37
157_F276_R0.8300.37
296_Q305_F0.8290.37
64_V90_S0.8280.37
5_Y18_E0.8280.37
78_G326_I0.8270.37
21_N24_D0.8270.37
75_Q81_V0.8200.36
189_F349_A0.8200.36
388_Q392_Q0.8150.36
210_I214_L0.8130.36
29_P50_A0.8120.36
23_V77_L0.8100.36
44_K130_R0.8060.35
192_R224_D0.8030.35
9_H12_G0.8020.35
222_G302_K0.8010.35
137_D160_R0.7960.35
137_D303_A0.7950.35
301_E335_G0.7930.35
155_N166_S0.7890.34
280_I319_I0.7860.34
101_A285_D0.7860.34
81_V140_A0.7840.34
5_Y8_E0.7840.34
304_L316_K0.7820.34
386_P397_Q0.7820.34
309_R316_K0.7820.34
294_T300_A0.7800.34
6_L13_A0.7790.34
292_A337_I0.7770.34
67_N74_L0.7770.34
163_E300_A0.7740.33
6_L21_N0.7740.33
322_Q371_I0.7730.33
293_S296_Q0.7720.33
404_G408_R0.7700.33
290_M338_A0.7680.33
71_V88_K0.7670.33
217_A220_S0.7670.33
160_R164_W0.7640.33
94_R268_L0.7620.33
265_V345_L0.7590.32
192_R223_A0.7580.32
391_P397_Q0.7580.32
33_G37_E0.7580.32
154_I272_A0.7530.32
360_G368_K0.7530.32
196_T218_K0.7520.32
178_D280_I0.7520.32
36_T43_E0.7500.32
144_V276_R0.7490.32
111_E283_S0.7490.32
128_K135_K0.7480.32
385_K393_Q0.7460.32
10_V49_S0.7460.32
9_H194_F0.7440.31
299_G318_G0.7440.31
27_T154_I0.7430.31
113_Y154_I0.7430.31
180_E244_Y0.7410.31
315_P338_A0.7390.31
88_K95_E0.7370.31
205_F208_Q0.7370.31
159_E317_H0.7350.31
8_E280_I0.7350.31
296_Q316_K0.7340.31
19_N172_L0.7340.31
71_V154_I0.7330.31
49_S56_K0.7330.31
290_M295_I0.7330.31
183_A241_L0.7330.31
54_L154_I0.7320.31
308_L322_Q0.7310.31
377_K380_Q0.7310.31
125_T288_A0.7300.31
54_L83_Y0.7300.31
144_V367_L0.7290.31
9_H15_A0.7290.31
300_A305_F0.7290.31
139_L353_A0.7280.31
189_F213_I0.7270.30
137_D164_W0.7270.30
9_H72_P0.7240.30
54_L72_P0.7240.30
190_G249_N0.7210.30
325_A366_Q0.7200.30
316_K335_G0.7190.30
42_N73_K0.7180.30
112_D372_D0.7170.30
327_H334_R0.7170.30
83_Y87_S0.7160.30
132_A153_T0.7160.30
393_Q397_Q0.7160.30
386_P404_G0.7160.30
296_Q315_P0.7150.30
385_K390_K0.7110.29
230_L321_F0.7110.29
203_L238_N0.7070.29
293_S300_A0.7070.29
97_L113_Y0.7040.29
288_A354_F0.7000.29
81_V86_Y0.6980.29
15_A42_N0.6960.29
150_I225_I0.6930.28
265_V350_R0.6930.28
296_Q300_A0.6930.28
138_L370_R0.6920.28
288_A365_E0.6890.28
48_F84_E0.6880.28
6_L58_V0.6880.28
11_I19_N0.6870.28
100_V166_S0.6870.28
37_E226_S0.6860.28
137_D335_G0.6860.28
53_E321_F0.6860.28
366_Q369_K0.6860.28
378_F383_P0.6850.28
31_D80_R0.6850.28
390_K396_K0.6840.28
39_L213_I0.6820.28
62_E235_M0.6810.28
18_E230_L0.6770.28
19_N110_E0.6770.28
55_L364_N0.6760.27
7_I18_E0.6750.27
134_Q336_K0.6730.27
374_I382_P0.6720.27
68_E71_V0.6710.27
60_P175_L0.6710.27
172_L349_A0.6700.27
187_S213_I0.6680.27
387_Q392_Q0.6680.27
182_Y243_L0.6670.27
292_A347_I0.6660.27
8_E109_N0.6650.27
16_Y32_L0.6650.27
195_L202_E0.6620.27
359_I367_L0.6620.27
113_Y238_N0.6610.27
139_L375_K0.6600.27
67_N70_E0.6590.27
203_L346_A0.6580.26
46_I49_S0.6580.26
190_G199_S0.6560.26
305_F315_P0.6550.26
21_N83_Y0.6540.26
242_D326_I0.6540.26
150_I250_L0.6510.26
297_V303_A0.6490.26
306_R310_S0.6480.26
340_A345_L0.6470.26
188_R199_S0.6460.26
144_V150_I0.6440.26
56_K85_P0.6430.26
149_D206_N0.6430.26
269_V320_I0.6420.26
10_V32_L0.6420.26
161_L183_A0.6410.26
168_H307_A0.6400.26
118_H122_L0.6390.25
31_D57_K0.6390.25
37_E55_L0.6380.25
90_S336_K0.6350.25
140_A208_Q0.6340.25
11_I237_A0.6320.25
160_R305_F0.6320.25
245_N337_I0.6280.25
153_T257_V0.6280.25
166_S247_R0.6270.25
57_K68_E0.6270.25
16_Y38_E0.6270.25
366_Q370_R0.6250.25
333_Q348_A0.6250.25
341_L345_L0.6210.24
396_K401_G0.6210.24
156_L273_L0.6200.24
279_S320_I0.6200.24
238_N269_V0.6200.24
252_N256_G0.6190.24
10_V50_A0.6190.24
337_I363_L0.6170.24
56_K60_P0.6130.24
67_N174_K0.6120.24
367_L370_R0.6120.24
37_E364_N0.6120.24
19_N24_D0.6120.24
47_P193_G0.6120.24
14_V213_I0.6110.24
147_M332_W0.6110.24
301_E315_P0.6110.24
23_V26_I0.6100.24
251_N266_T0.6090.24
156_L161_L0.6080.24
393_Q401_G0.6080.24
182_Y191_D0.6060.24
134_Q153_T0.6040.24
147_M246_I0.6030.24
226_S243_L0.6020.24
8_E20_G0.6020.24
5_Y85_P0.6000.23
301_E309_R0.6000.23
328_T354_F0.6000.23
7_I85_P0.5990.23
218_K313_R0.5980.23
121_S182_Y0.5980.23
168_H192_R0.5960.23
247_R275_A0.5960.23
300_A316_K0.5960.23
186_V240_I0.5930.23
112_D115_N0.5930.23
144_V156_L0.5930.23
156_L268_L0.5910.23
393_Q405_G0.5900.23
293_S316_K0.5900.23
26_I58_V0.5890.23
296_Q335_G0.5890.23
32_L358_F0.5860.23
391_P402_K0.5810.22
144_V243_L0.5810.22
251_N369_K0.5790.22
158_S186_V0.5790.22
142_Q149_D0.5780.22
32_L255_E0.5780.22
123_E134_Q0.5760.22
9_H17_D0.5750.22
129_L266_T0.5750.22
305_F335_G0.5740.22
20_G25_Y0.5730.22
338_A371_I0.5730.22
232_A245_N0.5720.22
229_D296_Q0.5700.22
137_D301_E0.5700.22
16_Y27_T0.5690.22
24_D29_P0.5690.22
24_D329_S0.5670.22
229_D233_M0.5670.22
206_N209_R0.5640.22
325_A328_T0.5630.22
159_E314_P0.5620.22
21_N26_I0.5610.22
125_T286_E0.5600.21
94_R162_R0.5590.21
59_N68_E0.5590.21
162_R193_G0.5590.21
245_N320_I0.5590.21
51_T70_E0.5590.21
11_I26_I0.5580.21
372_D376_E0.5570.21
307_A314_P0.5560.21
64_V88_K0.5560.21
119_E132_A0.5550.21
386_P394_P0.5510.21
51_T67_N0.5510.21
268_L326_I0.5510.21
11_I230_L0.5500.21
289_K334_R0.5500.21
157_F239_T0.5490.21
164_W168_H0.5480.21
229_D301_E0.5470.21
301_E314_P0.5470.21
368_K372_D0.5460.21
6_L19_N0.5450.21
247_R327_H0.5440.21
157_F283_S0.5440.21
227_E230_L0.5420.21
229_D253_Y0.5420.21
137_D315_P0.5420.21
65_V74_L0.5420.21
31_D34_K0.5410.21
145_R311_G0.5410.21
155_N293_S0.5410.21
168_H335_G0.5410.21
89_V113_Y0.5390.20
39_L47_P0.5380.20
132_A228_D0.5360.20
304_L308_L0.5360.20
16_Y369_K0.5360.20
194_F202_E0.5360.20
223_A280_I0.5350.20
242_D264_N0.5330.20
348_A363_L0.5330.20
15_A59_N0.5320.20
303_A335_G0.5320.20
27_T117_L0.5320.20
16_Y49_S0.5310.20
283_S307_A0.5300.20
12_G21_N0.5300.20
155_N315_P0.5290.20
165_Y344_K0.5270.20
390_K397_Q0.5270.20
284_L349_A0.5260.20
360_G371_I0.5260.20
6_L43_E0.5250.20
36_T40_L0.5240.20
137_D316_K0.5240.20
276_R322_Q0.5240.20
311_G321_F0.5240.20
161_L372_D0.5230.20
187_S385_K0.5220.20
315_P342_A0.5220.20
57_K192_R0.5220.20
179_H186_V0.5220.20
198_D206_N0.5200.20
188_R203_L0.5190.20
292_A340_A0.5180.20
137_D304_L0.5180.20
228_D231_S0.5170.19
142_Q304_L0.5170.19
54_L79_Y0.5170.19
38_E61_Q0.5170.19
12_G176_I0.5160.19
23_V58_V0.5160.19
41_N62_E0.5150.19
305_F314_P0.5140.19
51_T55_L0.5130.19
26_I41_N0.5130.19
360_G370_R0.5130.19
142_Q308_L0.5120.19
264_N352_D0.5110.19
225_I355_S0.5110.19
303_A309_R0.5100.19
156_L326_I0.5100.19
154_I188_R0.5100.19
280_I295_I0.5090.19
20_G96_S0.5090.19
205_F210_I0.5090.19
26_I34_K0.5080.19
37_E50_A0.5080.19
72_P78_G0.5070.19
23_V104_I0.5070.19
8_E54_L0.5060.19
219_K353_A0.5050.19
135_K311_G0.5050.19
351_V355_S0.5040.19
182_Y249_N0.5040.19
167_I309_R0.5040.19
15_A31_D0.5030.19
211_N245_N0.5010.19
359_I363_L0.5010.19
109_N211_N0.5000.19
199_S214_L0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3plaA 2 0.9102 100 0.166 Contact Map
2nnwA 2 0.8422 100 0.189 Contact Map
3icxA 2 0.5461 100 0.345 Contact Map
2ozbB 1 0.5777 100 0.35 Contact Map
1nt2B 2 0.5631 100 0.46 Contact Map
3id6A 2 0.6262 100 0.516 Contact Map
3gquA 1 0.284 100 0.597 Contact Map
3j9tA 1 0.3204 34.7 0.976 Contact Map
2a1jA 1 0.1359 24.1 0.978 Contact Map
2kw2A 1 0.233 20.6 0.978 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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