GREMLIN Database
Y942 - Putative HTH-type transcriptional regulatory protein SSO0942
UniProt: Q97ZH1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 310 (285)
Sequences: 151 (119)
Seq/√Len: 7.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
48_S52_I4.3540.98
18_Y48_S3.8500.95
33_V227_A3.3640.90
6_I163_E3.0340.84
64_A254_K2.8440.80
106_K173_G2.5150.71
98_F265_T2.4400.68
73_V121_R2.4090.67
33_V50_D2.4070.67
33_V75_T2.3640.66
91_F160_V2.3290.65
137_G147_R2.2980.64
71_S165_A2.1970.60
91_F172_F2.1850.59
293_N296_H2.1820.59
103_N109_L2.1450.58
176_I291_E2.1360.58
33_V87_A2.1340.58
139_V150_I2.0980.56
82_I100_K2.0850.56
35_I208_L2.0430.54
72_L109_L2.0250.53
231_V289_T2.0080.53
26_P151_Y1.9960.52
56_E258_A1.9860.52
45_I219_A1.9810.52
113_R148_K1.9730.51
183_D187_S1.9490.50
74_V98_F1.8950.48
94_S296_H1.8840.48
72_L163_E1.8570.47
32_S56_E1.8430.46
133_G272_I1.8220.46
74_V104_G1.8120.45
176_I224_L1.7890.44
50_D227_A1.7850.44
71_S130_E1.7760.44
121_R178_G1.7630.43
131_E191_I1.7400.42
261_L280_K1.7100.41
74_V127_H1.7080.41
74_V234_S1.7030.41
225_T240_L1.6940.41
74_V217_L1.6830.40
143_L172_F1.6620.40
59_D294_D1.6580.39
137_G148_K1.6400.39
75_T111_R1.6400.39
121_R270_V1.6390.39
120_I176_I1.6260.38
33_V169_I1.6060.38
290_Y294_D1.6020.37
44_L222_L1.5920.37
50_D75_T1.5910.37
82_I225_T1.5860.37
21_T115_G1.5600.36
75_T227_A1.5330.35
166_E212_L1.5320.35
38_N160_V1.5250.35
132_M172_F1.5040.34
64_A253_K1.5000.34
80_E115_G1.4980.34
71_S217_L1.4900.33
95_P171_L1.4800.33
150_I172_F1.4650.33
52_I121_R1.4390.32
43_T146_S1.4280.31
113_R151_Y1.3990.30
84_S127_H1.3890.30
87_A227_A1.3750.30
92_A152_D1.3710.29
69_T169_I1.3670.29
122_N171_L1.3580.29
169_I227_A1.3570.29
87_A169_I1.3370.28
44_L175_D1.3330.28
30_R113_R1.3250.28
84_S107_I1.3200.28
41_E274_R1.3090.28
214_E224_L1.3060.27
104_G110_Y1.3060.27
133_G280_K1.2980.27
32_S287_Y1.2940.27
80_E114_G1.2930.27
71_S118_I1.2860.27
162_L233_D1.2790.27
15_D72_L1.2780.27
48_S73_V1.2770.27
156_G168_L1.2740.26
107_I111_R1.2680.26
75_T115_G1.2660.26
197_A208_L1.2570.26
120_I141_K1.2560.26
107_I226_A1.2550.26
140_A165_A1.2550.26
160_V281_E1.2450.26
65_V246_K1.2450.26
63_I231_V1.2400.25
94_S205_K1.2390.25
108_F257_E1.2360.25
90_V206_A1.2330.25
56_E148_K1.2280.25
48_S75_T1.2260.25
103_N255_F1.2150.25
125_L164_V1.1960.24
84_S97_G1.1940.24
72_L95_P1.1760.24
39_S51_K1.1750.24
75_T216_G1.1670.23
35_I198_E1.1660.23
85_V97_G1.1580.23
18_Y33_V1.1580.23
72_L161_S1.1540.23
254_K271_I1.1490.23
52_I224_L1.1470.23
79_E85_V1.1250.22
90_V170_D1.1200.22
59_D91_F1.1200.22
246_K249_N1.1190.22
38_N91_F1.1170.22
185_I264_Y1.1120.22
169_I229_L1.0970.22
286_G289_T1.0950.21
261_L293_N1.0890.21
134_Y254_K1.0880.21
114_G117_F1.0850.21
48_S121_R1.0800.21
129_R135_S1.0750.21
53_T269_L1.0740.21
90_V230_I1.0730.21
52_I73_V1.0720.21
50_D121_R1.0710.21
87_A146_S1.0690.21
146_S227_A1.0570.20
100_K144_G1.0570.20
130_E165_A1.0530.20
30_R151_Y1.0440.20
176_I273_I1.0430.20
140_A219_A1.0340.20
44_L221_S1.0310.20
50_D87_A1.0290.20
64_A90_V1.0290.20
33_V37_L1.0260.20
16_K30_R1.0230.20
176_I292_E1.0220.20
94_S119_K1.0200.20
44_L228_D1.0180.20
92_A267_S1.0170.19
252_M293_N1.0150.19
141_K263_S1.0140.19
18_Y39_S1.0110.19
70_A271_I1.0090.19
88_D98_F1.0070.19
17_K174_D1.0070.19
51_K152_D1.0010.19
168_L176_I0.9910.19
148_K243_I0.9890.19
33_V111_R0.9870.19
221_S288_K0.9870.19
234_S300_D0.9870.19
64_A186_K0.9860.19
97_G118_I0.9800.19
75_T87_A0.9790.19
27_E69_T0.9770.19
201_P294_D0.9710.18
80_E109_L0.9700.18
58_S273_I0.9640.18
104_G164_V0.9640.18
89_N264_Y0.9600.18
282_C286_G0.9560.18
231_V282_C0.9540.18
50_D91_F0.9500.18
20_Y107_I0.9490.18
36_V258_A0.9460.18
102_I163_E0.9450.18
84_S166_E0.9450.18
69_T77_E0.9400.18
214_E272_I0.9380.18
50_D288_K0.9350.18
54_K170_D0.9280.17
143_L260_K0.9230.17
126_K184_S0.9220.17
50_D222_L0.9170.17
85_V107_I0.9160.17
96_E268_E0.9150.17
81_D109_L0.9140.17
157_D230_I0.9130.17
171_L235_D0.9110.17
231_V242_T0.9080.17
175_D179_D0.9060.17
128_K132_M0.9060.17
65_V127_H0.9040.17
89_N117_F0.9030.17
101_V106_K0.9030.17
136_I250_K0.9020.17
37_L227_A0.9010.17
290_Y298_L0.8960.17
45_I218_N0.8930.17
99_K261_L0.8910.17
33_V242_T0.8860.17
77_E262_A0.8860.17
76_N262_A0.8850.16
103_N219_A0.8820.16
143_L150_I0.8810.16
120_I125_L0.8780.16
273_I291_E0.8720.16
149_A221_S0.8710.16
44_L163_E0.8670.16
93_I109_L0.8660.16
18_Y52_I0.8590.16
34_D153_Y0.8590.16
75_T85_V0.8570.16
102_I254_K0.8570.16
99_K254_K0.8560.16
33_V226_A0.8520.16
26_P30_R0.8460.16
116_I287_Y0.8430.16
226_A282_C0.8410.16
180_V183_D0.8400.16
180_V239_Y0.8370.16
121_R170_D0.8350.15
162_L217_L0.8350.15
111_R227_A0.8320.15
47_V213_K0.8290.15
40_K103_N0.8220.15
18_Y87_A0.8220.15
67_T262_A0.8210.15
53_T60_L0.8170.15
47_V261_L0.8170.15
286_G293_N0.8130.15
32_S260_K0.8100.15
21_T53_T0.8090.15
82_I162_L0.8070.15
124_I149_A0.7920.15
151_Y167_K0.7870.15
137_G144_G0.7870.15
54_K253_K0.7840.14
42_P98_F0.7840.14
151_Y260_K0.7780.14
3_K272_I0.7780.14
31_K288_K0.7690.14
135_S153_Y0.7680.14
176_I215_S0.7660.14
47_V230_I0.7640.14
42_P128_K0.7640.14
20_Y268_E0.7600.14
33_V107_I0.7600.14
77_E104_G0.7520.14
95_P172_F0.7470.14
88_D160_V0.7460.14
36_V247_D0.7450.14
46_R85_V0.7450.14
60_L167_K0.7430.14
107_I241_V0.7430.14
88_D122_N0.7400.14
109_L274_R0.7400.14
215_S274_R0.7380.14
66_S119_K0.7370.14
80_E228_D0.7360.14
125_L149_A0.7360.14
9_V225_T0.7350.14
47_V147_R0.7320.13
24_E280_K0.7280.13
129_R153_Y0.7240.13
36_V53_T0.7220.13
103_N140_A0.7220.13
40_K200_S0.7200.13
93_I123_Y0.7190.13
117_F136_I0.7190.13
39_S48_S0.7170.13
26_P260_K0.7170.13
65_V131_E0.7160.13
101_V287_Y0.7140.13
43_T274_R0.7130.13
92_A99_K0.7130.13
147_R216_G0.7120.13
104_G131_E0.7120.13
35_I188_K0.7120.13
60_L91_F0.7070.13
74_V146_S0.7050.13
48_S91_F0.7030.13
17_K79_E0.7010.13
92_A180_V0.7000.13
75_T169_I0.6990.13
87_A226_A0.6990.13
124_I289_T0.6970.13
17_K134_Y0.6970.13
96_E224_L0.6960.13
92_A173_G0.6950.13
98_F101_V0.6950.13
167_K250_K0.6950.13
97_G111_R0.6930.13
121_R152_D0.6910.13
6_I252_M0.6910.13
36_V103_N0.6890.13
170_D286_G0.6870.13
163_E290_Y0.6830.13
102_I269_L0.6810.13
67_T271_I0.6810.13
136_I179_D0.6790.13
33_V115_G0.6780.13
112_T159_D0.6780.13
106_K175_D0.6730.12
172_F256_Y0.6720.12
72_L131_E0.6720.12
111_R115_G0.6710.12
37_L226_A0.6700.12
51_K90_V0.6680.12
73_V184_S0.6640.12
72_L184_S0.6540.12
102_I225_T0.6540.12
75_T97_G0.6520.12
47_V180_V0.6510.12
67_T97_G0.6500.12
203_N250_K0.6470.12
177_I231_V0.6460.12
80_E117_F0.6460.12
152_D226_A0.6450.12
48_S115_G0.6430.12
25_Y53_T0.6420.12
124_I281_E0.6410.12
123_Y224_L0.6410.12
277_K300_D0.6410.12
146_S252_M0.6380.12
12_I45_I0.6370.12
118_I163_E0.6350.12
45_I299_I0.6340.12
166_E232_K0.6340.12
54_K90_V0.6320.12
86_K113_R0.6320.12
237_N261_L0.6290.12
168_L238_R0.6250.12
179_D224_L0.6210.12
31_K143_L0.6180.12
13_L131_E0.6170.12
111_R139_V0.6170.12
26_P32_S0.6160.12
272_I283_E0.6160.12
82_I183_D0.6160.12
55_E94_S0.6130.11
128_K254_K0.6130.11
235_D297_S0.6120.11
5_I116_I0.6110.11
95_P163_E0.6110.11
115_G169_I0.6110.11
108_F260_K0.6100.11
171_L202_E0.6090.11
17_K98_F0.6090.11
55_E239_Y0.6080.11
18_Y185_I0.6060.11
109_L198_E0.6050.11
133_G155_K0.6050.11
60_L154_E0.6040.11
79_E254_K0.6040.11
97_G136_I0.6030.11
73_V271_I0.6030.11
78_E104_G0.6020.11
44_L295_I0.5990.11
116_I125_L0.5980.11
259_K289_T0.5980.11
106_K258_A0.5950.11
40_K93_I0.5910.11
54_K92_A0.5870.11
183_D208_L0.5840.11
172_F280_K0.5830.11
102_I128_K0.5810.11
127_H131_E0.5780.11
46_R153_Y0.5780.11
24_E92_A0.5750.11
74_V122_N0.5740.11
88_D152_D0.5740.11
49_E172_F0.5740.11
79_E156_G0.5730.11
36_V291_E0.5720.11
74_V250_K0.5700.11
223_K297_S0.5690.11
249_N263_S0.5680.11
107_I115_G0.5680.11
169_I226_A0.5670.11
261_L274_R0.5670.11
198_E203_N0.5620.11
113_R155_K0.5550.11
163_E212_L0.5520.11
40_K95_P0.5510.11
44_L202_E0.5510.11
20_Y100_K0.5500.11
82_I133_G0.5480.11
121_R217_L0.5470.10
31_K35_I0.5470.10
9_V168_L0.5450.10
50_D169_I0.5450.10
36_V63_I0.5440.10
24_E119_K0.5440.10
18_Y38_N0.5420.10
240_L254_K0.5400.10
64_A272_I0.5370.10
13_L270_V0.5360.10
51_K160_V0.5350.10
156_G286_G0.5340.10
138_D165_A0.5330.10
70_A171_L0.5330.10
91_F168_L0.5320.10
201_P283_E0.5310.10
11_D262_A0.5300.10
115_G216_G0.5280.10
201_P222_L0.5270.10
105_E179_D0.5270.10
13_L48_S0.5250.10
215_S239_Y0.5220.10
94_S293_N0.5190.10
94_S162_L0.5190.10
111_R169_I0.5180.10
113_R152_D0.5170.10
247_D260_K0.5160.10
148_K151_Y0.5140.10
12_I150_I0.5130.10
32_S137_G0.5120.10
72_L251_S0.5110.10
170_D173_G0.5090.10
45_I122_N0.5080.10
133_G200_S0.5070.10
168_L268_E0.5070.10
203_N280_K0.5060.10
37_L152_D0.5040.10
44_L60_L0.5040.10
40_K43_T0.5030.10
163_E176_I0.5020.10
38_N48_S0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2a6cA 2 0.2419 98.7 0.892 Contact Map
2ppxA 4 0.2 98.6 0.896 Contact Map
3f52A 2 0.2581 98.6 0.898 Contact Map
2p5tA 2 0.2806 98.5 0.9 Contact Map
4jcyA 2 0.2839 98.5 0.9 Contact Map
2auwA 2 0.4903 98.5 0.901 Contact Map
3fmyA 2 0.1935 98.5 0.901 Contact Map
3cecA 1 0.2806 98.4 0.902 Contact Map
4o8bA 2 0.3097 98.4 0.902 Contact Map
3tysA 2 0.2419 98.4 0.902 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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