GREMLIN Database
TRM1 - tRNA (guanine(26)-N(2))-dimethyltransferase
UniProt: Q97ZH0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 378 (348)
Sequences: 677 (500)
Seq/√Len: 26.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
241_K278_I5.1941.00
208_Y283_S5.1181.00
350_D364_D4.5801.00
246_C249_C4.2911.00
70_G85_L4.2051.00
246_C266_C4.1681.00
47_S73_Y3.5301.00
94_S97_Q3.4821.00
113_K121_E3.4551.00
249_C263_C3.1741.00
208_Y224_R3.1371.00
126_Y153_A3.0831.00
176_A191_V2.8711.00
287_L310_L2.8081.00
349_G366_E2.7611.00
246_C263_C2.7521.00
84_I124_S2.6650.99
135_P156_A2.6520.99
50_V286_F2.5740.99
249_C266_C2.5490.99
64_S70_G2.5180.99
196_I223_V2.5040.99
50_V290_I2.4360.99
64_S85_L2.4260.99
263_C266_C2.4170.99
146_A150_G2.4070.99
256_E259_C2.3790.99
354_T360_G2.3750.99
372_K375_K2.3230.98
125_D147_T2.2130.98
169_S173_K2.1620.97
366_E369_E2.1600.97
197_I277_Y2.1030.97
208_Y226_E2.0940.97
120_Y141_S2.0800.97
40_M43_N1.9900.96
119_L142_S1.9610.95
195_K199_E1.9600.95
139_I195_K1.9490.95
62_A115_A1.9460.95
287_L313_I1.9360.95
193_I223_V1.8670.94
231_K234_D1.8660.94
98_I101_K1.8640.94
149_N226_E1.8410.93
285_E289_R1.8390.93
199_E202_I1.8130.93
60_V119_L1.8110.93
207_V225_V1.7940.93
361_I370_I1.7870.92
118_L124_S1.7810.92
59_I73_Y1.7490.92
139_I196_I1.7300.91
194_G240_L1.7290.91
82_Q109_K1.7200.91
188_G219_Y1.7020.90
134_S264_P1.6820.90
161_P166_S1.6770.90
69_R220_R1.6760.90
54_L151_I1.6680.89
295_S307_Q1.6600.89
26_K29_P1.6590.89
126_Y151_I1.6560.89
50_V53_I1.6390.89
156_A192_L1.6380.89
188_G192_L1.6340.88
210_L286_F1.6220.88
140_L203_L1.6210.88
323_F356_F1.5780.87
116_N120_Y1.5640.86
100_A110_I1.5590.86
49_I294_Y1.5490.86
197_I201_A1.5400.85
35_F45_D1.5210.85
288_K314_E1.4960.83
176_A194_G1.4960.83
284_M318_R1.4700.82
197_I207_V1.4690.82
206_T235_N1.4690.82
143_L152_V1.4630.82
170_C191_V1.4630.82
192_L229_A1.4350.81
69_R72_R1.4220.80
326_I359_T1.4160.80
163_E184_S1.4040.79
63_L115_A1.3950.79
193_I207_V1.3900.79
140_L202_I1.3590.77
212_S221_L1.3560.77
213_F222_F1.3420.76
160_S166_S1.3350.76
349_G365_K1.3340.76
48_V77_S1.3280.75
86_N111_Y1.3190.75
86_N96_I1.3130.74
183_S245_E1.3080.74
35_F44_R1.3040.74
192_L221_L1.3010.74
100_A108_A1.2940.73
59_I80_S1.2860.73
101_K106_E1.2750.72
216_D305_R1.2710.72
131_P218_Y1.2690.72
127_I145_A1.2670.72
341_I351_A1.2560.71
105_I108_A1.2450.70
201_A235_N1.2430.70
112_N196_I1.2400.70
49_I290_I1.2380.70
159_L219_Y1.2380.70
229_A233_D1.2330.70
177_I236_I1.2300.69
51_V153_A1.2280.69
51_V126_Y1.2260.69
119_L145_A1.2160.69
193_I209_P1.2100.68
104_G189_L1.2100.68
192_L219_Y1.2090.68
51_V77_S1.2090.68
197_I235_N1.1950.67
97_Q110_I1.1880.67
128_D220_R1.1870.67
61_D353_R1.1800.66
37_N43_N1.1740.66
47_S153_A1.1690.65
69_R128_D1.1670.65
43_N218_Y1.1640.65
142_S152_V1.1580.65
45_D72_R1.1530.64
90_P127_I1.1490.64
342_E345_L1.1440.64
154_F196_I1.1440.64
170_C178_N1.1430.64
166_S169_S1.1390.63
343_S346_E1.1370.63
343_S373_C1.1160.62
90_P112_N1.1090.61
73_Y126_Y1.1080.61
341_I371_T1.1030.61
282_Y313_I1.1030.61
189_L310_L1.0990.61
307_Q311_N1.0960.60
159_L188_G1.0940.60
120_Y144_N1.0920.60
35_F72_R1.0860.60
36_Y66_T1.0860.60
72_R128_D1.0850.60
146_A152_V1.0820.59
52_S127_I1.0820.59
135_P240_L1.0770.59
53_I290_I1.0710.59
41_T301_T1.0680.58
87_D115_A1.0650.58
57_K289_R1.0640.58
60_V118_L1.0590.58
241_K254_F1.0510.57
207_V223_V1.0500.57
151_I362_R1.0490.57
349_G369_E1.0430.56
43_N47_S1.0420.56
115_A119_L1.0410.56
282_Y362_R1.0380.56
73_Y153_A1.0350.56
103_N218_Y1.0300.56
91_N94_S1.0260.55
111_Y118_L1.0230.55
330_A374_I1.0190.55
172_R232_A1.0020.53
127_I147_T1.0010.53
348_L365_K1.0000.53
319_F350_D0.9950.53
333_L371_T0.9910.53
63_L138_F0.9850.52
72_R220_R0.9810.52
245_E250_G0.9780.52
143_L200_A0.9760.52
37_N131_P0.9760.52
291_M311_N0.9740.51
283_S343_S0.9660.51
62_A119_L0.9610.50
117_A120_Y0.9540.50
189_L212_S0.9490.49
349_G364_D0.9480.49
257_E261_T0.9450.49
197_I279_G0.9420.49
70_G138_F0.9220.47
43_N65_A0.9220.47
251_F270_F0.9160.47
213_F313_I0.9130.47
50_V54_L0.9090.46
125_D153_A0.9070.46
161_P170_C0.9060.46
59_I114_D0.8970.46
344_I365_K0.8930.45
288_K292_D0.8910.45
143_L205_K0.8910.45
103_N131_P0.8870.45
207_V342_E0.8780.44
34_V92_A0.8760.44
317_A362_R0.8760.44
92_A131_P0.8750.44
253_T270_F0.8750.44
45_D69_R0.8730.44
221_L272_I0.8710.44
364_D368_E0.8640.43
40_M132_F0.8600.43
256_E260_K0.8550.42
327_S331_S0.8520.42
165_S178_N0.8520.42
134_S137_P0.8510.42
217_Y346_E0.8510.42
201_A279_G0.8500.42
43_N155_T0.8490.42
327_S359_T0.8460.42
201_A239_H0.8440.42
66_T336_S0.8430.42
71_I75_V0.8400.41
335_I338_I0.8390.41
119_L124_S0.8360.41
94_S349_G0.8350.41
212_S282_Y0.8310.41
345_L351_A0.8270.40
147_T289_R0.8270.40
156_A172_R0.8250.40
285_E288_K0.8220.40
146_A225_V0.8210.40
335_I374_I0.8190.40
61_D71_I0.8180.40
110_I353_R0.8130.39
194_G198_R0.8130.39
46_L211_F0.8120.39
160_S192_L0.8120.39
128_D157_T0.8110.39
113_K118_L0.8070.39
39_K216_D0.8060.39
143_L146_A0.8060.39
168_T203_L0.8040.39
54_L373_C0.8030.39
70_G325_N0.7990.38
41_T302_S0.7990.38
51_V339_P0.7970.38
333_L374_I0.7970.38
197_I223_V0.7970.38
183_S252_Q0.7940.38
64_S96_I0.7930.38
346_E369_E0.7910.38
317_A352_S0.7860.38
57_K63_L0.7850.37
332_K371_T0.7850.37
168_T233_D0.7840.37
162_L192_L0.7810.37
51_V59_I0.7810.37
35_F69_R0.7810.37
42_F302_S0.7760.37
101_K224_R0.7740.37
53_I287_L0.7680.36
93_T108_A0.7670.36
185_K214_Y0.7660.36
146_A359_T0.7630.36
178_N191_V0.7580.36
305_R308_K0.7570.35
29_P33_P0.7560.35
154_F290_I0.7550.35
109_K288_K0.7550.35
40_M218_Y0.7540.35
35_F128_D0.7530.35
137_P141_S0.7450.35
260_K284_M0.7450.35
72_R76_E0.7400.34
158_D186_E0.7380.34
83_L146_A0.7330.34
134_S173_K0.7330.34
113_K296_N0.7270.33
40_M217_Y0.7260.33
130_D158_D0.7260.33
291_M374_I0.7250.33
171_R177_I0.7250.33
191_V219_Y0.7220.33
267_G327_S0.7210.33
96_I362_R0.7200.33
25_G30_S0.7140.33
139_I199_E0.7130.33
218_Y222_F0.7070.32
319_F364_D0.7070.32
58_I189_L0.7060.32
128_D164_G0.7030.32
185_K323_F0.7020.32
330_A338_I0.7010.32
39_K119_L0.7010.32
239_H279_G0.6990.32
156_A170_C0.6960.31
179_H273_I0.6910.31
243_F273_I0.6910.31
75_V105_I0.6900.31
37_N40_M0.6870.31
65_A193_I0.6860.31
260_K264_P0.6850.31
170_C176_A0.6850.31
207_V273_I0.6850.31
281_L293_L0.6850.31
97_Q269_I0.6840.31
132_F341_I0.6840.31
135_P327_S0.6830.31
73_Y151_I0.6820.31
103_N286_F0.6820.31
309_L313_I0.6800.30
282_Y287_L0.6800.30
197_I206_T0.6770.30
248_R268_E0.6760.30
37_N92_A0.6760.30
206_T225_V0.6720.30
60_V224_R0.6720.30
163_E167_P0.6700.30
197_I210_L0.6700.30
197_I240_L0.6690.30
127_I361_I0.6680.30
159_L236_I0.6650.29
47_S161_P0.6650.29
165_S184_S0.6640.29
39_K70_G0.6630.29
61_D80_S0.6630.29
151_I280_P0.6630.29
236_I240_L0.6620.29
289_R292_D0.6610.29
33_P177_I0.6590.29
325_N359_T0.6580.29
96_I351_A0.6570.29
151_I155_T0.6560.29
43_N131_P0.6550.29
137_P155_T0.6550.29
316_E355_H0.6550.29
132_F137_P0.6550.29
159_L192_L0.6540.29
52_S78_W0.6530.29
102_N110_I0.6520.29
326_I358_P0.6510.29
276_L313_I0.6510.29
135_P176_A0.6500.29
129_I145_A0.6500.29
40_M47_S0.6490.28
207_V212_S0.6480.28
280_P366_E0.6460.28
347_C369_E0.6460.28
34_V138_F0.6460.28
291_M307_Q0.6450.28
31_W329_L0.6390.28
140_L199_E0.6380.28
183_S329_L0.6380.28
294_Y350_D0.6380.28
117_A121_E0.6350.28
329_L374_I0.6340.28
77_S126_Y0.6310.27
132_F194_G0.6300.27
280_P364_D0.6280.27
304_N307_Q0.6280.27
39_K71_I0.6250.27
321_N324_Y0.6220.27
72_R133_G0.6220.27
342_E346_E0.6190.27
180_K184_S0.6190.27
291_M366_E0.6160.26
257_E315_K0.6160.26
65_A69_R0.6140.26
235_N240_L0.6130.26
68_I308_K0.6130.26
72_R209_P0.6130.26
60_V193_I0.6130.26
154_F172_R0.6100.26
191_V235_N0.6100.26
140_L286_F0.6100.26
221_L306_I0.6100.26
155_T174_Y0.6090.26
55_K188_G0.6090.26
235_N307_Q0.6090.26
66_T125_D0.6090.26
194_G360_G0.6090.26
112_N283_S0.6070.26
338_I358_P0.6060.26
220_R362_R0.6060.26
315_K350_D0.6050.26
41_T48_V0.6050.26
59_I170_C0.6050.26
324_Y367_Y0.6040.26
365_K370_I0.6020.26
349_G363_T0.6020.26
228_G233_D0.6010.26
42_F309_L0.6000.26
352_S355_H0.6000.26
225_V285_E0.5990.26
346_E366_E0.5970.25
254_F278_I0.5960.25
130_D157_T0.5960.25
35_F133_G0.5950.25
105_I373_C0.5940.25
256_E261_T0.5940.25
83_L100_A0.5940.25
50_V139_I0.5920.25
93_T112_N0.5920.25
276_L322_V0.5920.25
96_I110_I0.5910.25
271_S300_L0.5900.25
328_K332_K0.5900.25
153_A183_S0.5880.25
61_D162_L0.5880.25
193_I210_L0.5880.25
84_I111_Y0.5870.25
326_I361_I0.5860.25
85_L127_I0.5850.25
163_E325_N0.5850.25
170_C351_A0.5830.25
196_I199_E0.5830.25
128_D209_P0.5820.25
45_D220_R0.5810.24
129_I370_I0.5800.24
84_I118_L0.5790.24
53_I293_L0.5780.24
40_M308_K0.5780.24
347_C372_K0.5770.24
37_N103_N0.5770.24
128_D158_D0.5740.24
295_S323_F0.5740.24
139_I296_N0.5730.24
175_D189_L0.5730.24
251_F367_Y0.5720.24
37_N218_Y0.5710.24
41_T132_F0.5710.24
267_G270_F0.5710.24
331_S336_S0.5700.24
323_F327_S0.5680.24
40_M51_V0.5670.24
35_F220_R0.5670.24
47_S218_Y0.5670.24
178_N331_S0.5660.24
170_C324_Y0.5650.24
38_P64_S0.5620.23
344_I373_C0.5620.23
25_G28_D0.5610.23
286_F290_I0.5600.23
199_E203_L0.5580.23
91_N97_Q0.5580.23
293_L306_I0.5560.23
26_K281_L0.5550.23
119_L211_F0.5550.23
82_Q374_I0.5550.23
263_C267_G0.5530.23
192_L288_K0.5520.23
172_R369_E0.5520.23
174_Y186_E0.5520.23
66_T164_G0.5490.23
85_L211_F0.5480.23
100_A370_I0.5460.23
154_F202_I0.5460.23
138_F144_N0.5450.23
69_R209_P0.5450.23
242_Y297_F0.5450.23
158_D174_Y0.5450.23
172_R347_C0.5440.23
45_D128_D0.5430.22
58_I283_S0.5430.22
69_R130_D0.5430.22
106_E364_D0.5430.22
287_L315_K0.5430.22
89_N211_F0.5430.22
87_D92_A0.5410.22
98_I227_N0.5380.22
153_A222_F0.5370.22
147_T202_I0.5370.22
64_S76_E0.5360.22
59_I358_P0.5350.22
217_Y308_K0.5340.22
94_S98_I0.5340.22
180_K210_L0.5340.22
273_I287_L0.5320.22
163_E185_K0.5320.22
128_D133_G0.5320.22
134_S255_V0.5290.22
197_I241_K0.5290.22
64_S239_H0.5290.22
282_Y302_S0.5280.22
90_P241_K0.5270.22
72_R241_K0.5260.22
142_S275_P0.5260.22
69_R76_E0.5250.22
215_A309_L0.5230.21
251_F264_P0.5230.21
150_G158_D0.5230.21
317_A372_K0.5230.21
273_I369_E0.5220.21
206_T226_E0.5220.21
158_D164_G0.5220.21
49_I306_I0.5210.21
181_L252_Q0.5210.21
159_L322_V0.5210.21
27_F301_T0.5210.21
132_F140_L0.5180.21
170_C184_S0.5170.21
244_G249_C0.5170.21
159_L250_G0.5170.21
57_K296_N0.5160.21
37_N174_Y0.5150.21
260_K270_F0.5150.21
351_A362_R0.5140.21
154_F228_G0.5130.21
129_I368_E0.5110.21
54_L224_R0.5110.21
225_V288_K0.5100.21
277_Y294_Y0.5100.21
130_D220_R0.5100.21
109_K170_C0.5090.21
93_T330_A0.5080.21
49_I173_K0.5080.21
130_D164_G0.5060.21
116_N370_I0.5040.20
165_S182_S0.5040.20
179_H268_E0.5030.20
185_K228_G0.5030.20
342_E354_T0.5030.20
132_F242_Y0.5020.20
254_F330_A0.5020.20
210_L362_R0.5020.20
78_W156_A0.5010.20
340_P351_A0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2dulA 2 0.918 100 0.334 Contact Map
3axsA 2 0.963 100 0.397 Contact Map
3k6rA 1 0.5079 99.3 0.898 Contact Map
2yx1A 2 0.4894 99.2 0.901 Contact Map
1wxxA 2 0.537 99.2 0.904 Contact Map
3v97A 1 0.4894 99.2 0.904 Contact Map
3c0kA 2 0.4868 99.1 0.904 Contact Map
2igtA 4 0.5397 99.1 0.906 Contact Map
3vseA 1 0.5397 99.1 0.906 Contact Map
2b78A 1 0.5132 99.1 0.907 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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