TRM1 - SULSO - GREMLIN Contacts

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TRM1 - tRNA (guanine(26)-N(2))-dimethyltransferase

UniProt:	Q97ZH0	Sequences: MKLKEVTEGKVRIFVPDPTGYMVEGKFDPSWAPVFYNPKMTFNRDLSVIVVSILKPKIIVDALSATGIRGIRYYVESWKSEQLILNDKNPNATSLIQINAKNNGIENAKIYNKDANALLYEVKSDYIDIDPFGSPAPFILSSLNAATRNGIVAFTATDLSPLEGSSPTSCRRKYDAINHKLSSSKELGLRVLIGKIIREAAILEKTVYPLFSFYADYYYRLFVRVENGARKADDNINKHLKYFGECPRCGFQTFVEENCKTKCPVCGEIFSIIGPLYIGPLYSMEFLKRIMDLYSNFNYLTSFNRIQKLLNVIEKEARFKNVFYNISKLASKLKISAIPPIESILECLGDASRTHFAPTGIRTDKEYEEITKCIKSLR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	378 (348)
Sequences:	677 (500)
Seq/√Len:	26.8

HALSA - TRM1
SULSO - TRM1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
241_K	278_I	5.194	1.00
208_Y	283_S	5.118	1.00
350_D	364_D	4.580	1.00
246_C	249_C	4.291	1.00
70_G	85_L	4.205	1.00
246_C	266_C	4.168	1.00
47_S	73_Y	3.530	1.00
94_S	97_Q	3.482	1.00
113_K	121_E	3.455	1.00
249_C	263_C	3.174	1.00
208_Y	224_R	3.137	1.00
126_Y	153_A	3.083	1.00
176_A	191_V	2.871	1.00
287_L	310_L	2.808	1.00
349_G	366_E	2.761	1.00
246_C	263_C	2.752	1.00
84_I	124_S	2.665	0.99
135_P	156_A	2.652	0.99
50_V	286_F	2.574	0.99
249_C	266_C	2.549	0.99
64_S	70_G	2.518	0.99
196_I	223_V	2.504	0.99
50_V	290_I	2.436	0.99
64_S	85_L	2.426	0.99
263_C	266_C	2.417	0.99
146_A	150_G	2.407	0.99
256_E	259_C	2.379	0.99
354_T	360_G	2.375	0.99
372_K	375_K	2.323	0.98
125_D	147_T	2.213	0.98
169_S	173_K	2.162	0.97
366_E	369_E	2.160	0.97
197_I	277_Y	2.103	0.97
208_Y	226_E	2.094	0.97
120_Y	141_S	2.080	0.97
40_M	43_N	1.990	0.96
119_L	142_S	1.961	0.95
195_K	199_E	1.960	0.95
139_I	195_K	1.949	0.95
62_A	115_A	1.946	0.95
287_L	313_I	1.936	0.95
193_I	223_V	1.867	0.94
231_K	234_D	1.866	0.94
98_I	101_K	1.864	0.94
149_N	226_E	1.841	0.93
285_E	289_R	1.839	0.93
199_E	202_I	1.813	0.93
60_V	119_L	1.811	0.93
207_V	225_V	1.794	0.93
361_I	370_I	1.787	0.92
118_L	124_S	1.781	0.92
59_I	73_Y	1.749	0.92
139_I	196_I	1.730	0.91
194_G	240_L	1.729	0.91
82_Q	109_K	1.720	0.91
188_G	219_Y	1.702	0.90
134_S	264_P	1.682	0.90
161_P	166_S	1.677	0.90
69_R	220_R	1.676	0.90
54_L	151_I	1.668	0.89
295_S	307_Q	1.660	0.89
26_K	29_P	1.659	0.89
126_Y	151_I	1.656	0.89
50_V	53_I	1.639	0.89
156_A	192_L	1.638	0.89
188_G	192_L	1.634	0.88
210_L	286_F	1.622	0.88
140_L	203_L	1.621	0.88
323_F	356_F	1.578	0.87
116_N	120_Y	1.564	0.86
100_A	110_I	1.559	0.86
49_I	294_Y	1.549	0.86
197_I	201_A	1.540	0.85
35_F	45_D	1.521	0.85
288_K	314_E	1.496	0.83
176_A	194_G	1.496	0.83
284_M	318_R	1.470	0.82
197_I	207_V	1.469	0.82
206_T	235_N	1.469	0.82
143_L	152_V	1.463	0.82
170_C	191_V	1.463	0.82
192_L	229_A	1.435	0.81
69_R	72_R	1.422	0.80
326_I	359_T	1.416	0.80
163_E	184_S	1.404	0.79
63_L	115_A	1.395	0.79
193_I	207_V	1.390	0.79
140_L	202_I	1.359	0.77
212_S	221_L	1.356	0.77
213_F	222_F	1.342	0.76
160_S	166_S	1.335	0.76
349_G	365_K	1.334	0.76
48_V	77_S	1.328	0.75
86_N	111_Y	1.319	0.75
86_N	96_I	1.313	0.74
183_S	245_E	1.308	0.74
35_F	44_R	1.304	0.74
192_L	221_L	1.301	0.74
100_A	108_A	1.294	0.73
59_I	80_S	1.286	0.73
101_K	106_E	1.275	0.72
216_D	305_R	1.271	0.72
131_P	218_Y	1.269	0.72
127_I	145_A	1.267	0.72
341_I	351_A	1.256	0.71
105_I	108_A	1.245	0.70
201_A	235_N	1.243	0.70
112_N	196_I	1.240	0.70
49_I	290_I	1.238	0.70
159_L	219_Y	1.238	0.70
229_A	233_D	1.233	0.70
177_I	236_I	1.230	0.69
51_V	153_A	1.228	0.69
51_V	126_Y	1.226	0.69
119_L	145_A	1.216	0.69
193_I	209_P	1.210	0.68
104_G	189_L	1.210	0.68
192_L	219_Y	1.209	0.68
51_V	77_S	1.209	0.68
197_I	235_N	1.195	0.67
97_Q	110_I	1.188	0.67
128_D	220_R	1.187	0.67
61_D	353_R	1.180	0.66
37_N	43_N	1.174	0.66
47_S	153_A	1.169	0.65
69_R	128_D	1.167	0.65
43_N	218_Y	1.164	0.65
142_S	152_V	1.158	0.65
45_D	72_R	1.153	0.64
90_P	127_I	1.149	0.64
342_E	345_L	1.144	0.64
154_F	196_I	1.144	0.64
170_C	178_N	1.143	0.64
166_S	169_S	1.139	0.63
343_S	346_E	1.137	0.63
343_S	373_C	1.116	0.62
90_P	112_N	1.109	0.61
73_Y	126_Y	1.108	0.61
341_I	371_T	1.103	0.61
282_Y	313_I	1.103	0.61
189_L	310_L	1.099	0.61
307_Q	311_N	1.096	0.60
159_L	188_G	1.094	0.60
120_Y	144_N	1.092	0.60
35_F	72_R	1.086	0.60
36_Y	66_T	1.086	0.60
72_R	128_D	1.085	0.60
146_A	152_V	1.082	0.59
52_S	127_I	1.082	0.59
135_P	240_L	1.077	0.59
53_I	290_I	1.071	0.59
41_T	301_T	1.068	0.58
87_D	115_A	1.065	0.58
57_K	289_R	1.064	0.58
60_V	118_L	1.059	0.58
241_K	254_F	1.051	0.57
207_V	223_V	1.050	0.57
151_I	362_R	1.049	0.57
349_G	369_E	1.043	0.56
43_N	47_S	1.042	0.56
115_A	119_L	1.041	0.56
282_Y	362_R	1.038	0.56
73_Y	153_A	1.035	0.56
103_N	218_Y	1.030	0.56
91_N	94_S	1.026	0.55
111_Y	118_L	1.023	0.55
330_A	374_I	1.019	0.55
172_R	232_A	1.002	0.53
127_I	147_T	1.001	0.53
348_L	365_K	1.000	0.53
319_F	350_D	0.995	0.53
333_L	371_T	0.991	0.53
63_L	138_F	0.985	0.52
72_R	220_R	0.981	0.52
245_E	250_G	0.978	0.52
143_L	200_A	0.976	0.52
37_N	131_P	0.976	0.52
291_M	311_N	0.974	0.51
283_S	343_S	0.966	0.51
62_A	119_L	0.961	0.50
117_A	120_Y	0.954	0.50
189_L	212_S	0.949	0.49
349_G	364_D	0.948	0.49
257_E	261_T	0.945	0.49
197_I	279_G	0.942	0.49
70_G	138_F	0.922	0.47
43_N	65_A	0.922	0.47
251_F	270_F	0.916	0.47
213_F	313_I	0.913	0.47
50_V	54_L	0.909	0.46
125_D	153_A	0.907	0.46
161_P	170_C	0.906	0.46
59_I	114_D	0.897	0.46
344_I	365_K	0.893	0.45
288_K	292_D	0.891	0.45
143_L	205_K	0.891	0.45
103_N	131_P	0.887	0.45
207_V	342_E	0.878	0.44
34_V	92_A	0.876	0.44
317_A	362_R	0.876	0.44
92_A	131_P	0.875	0.44
253_T	270_F	0.875	0.44
45_D	69_R	0.873	0.44
221_L	272_I	0.871	0.44
364_D	368_E	0.864	0.43
40_M	132_F	0.860	0.43
256_E	260_K	0.855	0.42
327_S	331_S	0.852	0.42
165_S	178_N	0.852	0.42
134_S	137_P	0.851	0.42
217_Y	346_E	0.851	0.42
201_A	279_G	0.850	0.42
43_N	155_T	0.849	0.42
327_S	359_T	0.846	0.42
201_A	239_H	0.844	0.42
66_T	336_S	0.843	0.42
71_I	75_V	0.840	0.41
335_I	338_I	0.839	0.41
119_L	124_S	0.836	0.41
94_S	349_G	0.835	0.41
212_S	282_Y	0.831	0.41
345_L	351_A	0.827	0.40
147_T	289_R	0.827	0.40
156_A	172_R	0.825	0.40
285_E	288_K	0.822	0.40
146_A	225_V	0.821	0.40
335_I	374_I	0.819	0.40
61_D	71_I	0.818	0.40
110_I	353_R	0.813	0.39
194_G	198_R	0.813	0.39
46_L	211_F	0.812	0.39
160_S	192_L	0.812	0.39
128_D	157_T	0.811	0.39
113_K	118_L	0.807	0.39
39_K	216_D	0.806	0.39
143_L	146_A	0.806	0.39
168_T	203_L	0.804	0.39
54_L	373_C	0.803	0.39
70_G	325_N	0.799	0.38
41_T	302_S	0.799	0.38
51_V	339_P	0.797	0.38
333_L	374_I	0.797	0.38
197_I	223_V	0.797	0.38
183_S	252_Q	0.794	0.38
64_S	96_I	0.793	0.38
346_E	369_E	0.791	0.38
317_A	352_S	0.786	0.38
57_K	63_L	0.785	0.37
332_K	371_T	0.785	0.37
168_T	233_D	0.784	0.37
162_L	192_L	0.781	0.37
51_V	59_I	0.781	0.37
35_F	69_R	0.781	0.37
42_F	302_S	0.776	0.37
101_K	224_R	0.774	0.37
53_I	287_L	0.768	0.36
93_T	108_A	0.767	0.36
185_K	214_Y	0.766	0.36
146_A	359_T	0.763	0.36
178_N	191_V	0.758	0.36
305_R	308_K	0.757	0.35
29_P	33_P	0.756	0.35
154_F	290_I	0.755	0.35
109_K	288_K	0.755	0.35
40_M	218_Y	0.754	0.35
35_F	128_D	0.753	0.35
137_P	141_S	0.745	0.35
260_K	284_M	0.745	0.35
72_R	76_E	0.740	0.34
158_D	186_E	0.738	0.34
83_L	146_A	0.733	0.34
134_S	173_K	0.733	0.34
113_K	296_N	0.727	0.33
40_M	217_Y	0.726	0.33
130_D	158_D	0.726	0.33
291_M	374_I	0.725	0.33
171_R	177_I	0.725	0.33
191_V	219_Y	0.722	0.33
267_G	327_S	0.721	0.33
96_I	362_R	0.720	0.33
25_G	30_S	0.714	0.33
139_I	199_E	0.713	0.33
218_Y	222_F	0.707	0.32
319_F	364_D	0.707	0.32
58_I	189_L	0.706	0.32
128_D	164_G	0.703	0.32
185_K	323_F	0.702	0.32
330_A	338_I	0.701	0.32
39_K	119_L	0.701	0.32
239_H	279_G	0.699	0.32
156_A	170_C	0.696	0.31
179_H	273_I	0.691	0.31
243_F	273_I	0.691	0.31
75_V	105_I	0.690	0.31
37_N	40_M	0.687	0.31
65_A	193_I	0.686	0.31
260_K	264_P	0.685	0.31
170_C	176_A	0.685	0.31
207_V	273_I	0.685	0.31
281_L	293_L	0.685	0.31
97_Q	269_I	0.684	0.31
132_F	341_I	0.684	0.31
135_P	327_S	0.683	0.31
73_Y	151_I	0.682	0.31
103_N	286_F	0.682	0.31
309_L	313_I	0.680	0.30
282_Y	287_L	0.680	0.30
197_I	206_T	0.677	0.30
248_R	268_E	0.676	0.30
37_N	92_A	0.676	0.30
206_T	225_V	0.672	0.30
60_V	224_R	0.672	0.30
163_E	167_P	0.670	0.30
197_I	210_L	0.670	0.30
197_I	240_L	0.669	0.30
127_I	361_I	0.668	0.30
159_L	236_I	0.665	0.29
47_S	161_P	0.665	0.29
165_S	184_S	0.664	0.29
39_K	70_G	0.663	0.29
61_D	80_S	0.663	0.29
151_I	280_P	0.663	0.29
236_I	240_L	0.662	0.29
289_R	292_D	0.661	0.29
33_P	177_I	0.659	0.29
325_N	359_T	0.658	0.29
96_I	351_A	0.657	0.29
151_I	155_T	0.656	0.29
43_N	131_P	0.655	0.29
137_P	155_T	0.655	0.29
316_E	355_H	0.655	0.29
132_F	137_P	0.655	0.29
159_L	192_L	0.654	0.29
52_S	78_W	0.653	0.29
102_N	110_I	0.652	0.29
326_I	358_P	0.651	0.29
276_L	313_I	0.651	0.29
135_P	176_A	0.650	0.29
129_I	145_A	0.650	0.29
40_M	47_S	0.649	0.28
207_V	212_S	0.648	0.28
280_P	366_E	0.646	0.28
347_C	369_E	0.646	0.28
34_V	138_F	0.646	0.28
291_M	307_Q	0.645	0.28
31_W	329_L	0.639	0.28
140_L	199_E	0.638	0.28
183_S	329_L	0.638	0.28
294_Y	350_D	0.638	0.28
117_A	121_E	0.635	0.28
329_L	374_I	0.634	0.28
77_S	126_Y	0.631	0.27
132_F	194_G	0.630	0.27
280_P	364_D	0.628	0.27
304_N	307_Q	0.628	0.27
39_K	71_I	0.625	0.27
321_N	324_Y	0.622	0.27
72_R	133_G	0.622	0.27
342_E	346_E	0.619	0.27
180_K	184_S	0.619	0.27
291_M	366_E	0.616	0.26
257_E	315_K	0.616	0.26
65_A	69_R	0.614	0.26
235_N	240_L	0.613	0.26
68_I	308_K	0.613	0.26
72_R	209_P	0.613	0.26
60_V	193_I	0.613	0.26
154_F	172_R	0.610	0.26
191_V	235_N	0.610	0.26
140_L	286_F	0.610	0.26
221_L	306_I	0.610	0.26
155_T	174_Y	0.609	0.26
55_K	188_G	0.609	0.26
235_N	307_Q	0.609	0.26
66_T	125_D	0.609	0.26
194_G	360_G	0.609	0.26
112_N	283_S	0.607	0.26
338_I	358_P	0.606	0.26
220_R	362_R	0.606	0.26
315_K	350_D	0.605	0.26
41_T	48_V	0.605	0.26
59_I	170_C	0.605	0.26
324_Y	367_Y	0.604	0.26
365_K	370_I	0.602	0.26
349_G	363_T	0.602	0.26
228_G	233_D	0.601	0.26
42_F	309_L	0.600	0.26
352_S	355_H	0.600	0.26
225_V	285_E	0.599	0.26
346_E	366_E	0.597	0.25
254_F	278_I	0.596	0.25
130_D	157_T	0.596	0.25
35_F	133_G	0.595	0.25
105_I	373_C	0.594	0.25
256_E	261_T	0.594	0.25
83_L	100_A	0.594	0.25
50_V	139_I	0.592	0.25
93_T	112_N	0.592	0.25
276_L	322_V	0.592	0.25
96_I	110_I	0.591	0.25
271_S	300_L	0.590	0.25
328_K	332_K	0.590	0.25
153_A	183_S	0.588	0.25
61_D	162_L	0.588	0.25
193_I	210_L	0.588	0.25
84_I	111_Y	0.587	0.25
326_I	361_I	0.586	0.25
85_L	127_I	0.585	0.25
163_E	325_N	0.585	0.25
170_C	351_A	0.583	0.25
196_I	199_E	0.583	0.25
128_D	209_P	0.582	0.25
45_D	220_R	0.581	0.24
129_I	370_I	0.580	0.24
84_I	118_L	0.579	0.24
53_I	293_L	0.578	0.24
40_M	308_K	0.578	0.24
347_C	372_K	0.577	0.24
37_N	103_N	0.577	0.24
128_D	158_D	0.574	0.24
295_S	323_F	0.574	0.24
139_I	296_N	0.573	0.24
175_D	189_L	0.573	0.24
251_F	367_Y	0.572	0.24
37_N	218_Y	0.571	0.24
41_T	132_F	0.571	0.24
267_G	270_F	0.571	0.24
331_S	336_S	0.570	0.24
323_F	327_S	0.568	0.24
40_M	51_V	0.567	0.24
35_F	220_R	0.567	0.24
47_S	218_Y	0.567	0.24
178_N	331_S	0.566	0.24
170_C	324_Y	0.565	0.24
38_P	64_S	0.562	0.23
344_I	373_C	0.562	0.23
25_G	28_D	0.561	0.23
286_F	290_I	0.560	0.23
199_E	203_L	0.558	0.23
91_N	97_Q	0.558	0.23
293_L	306_I	0.556	0.23
26_K	281_L	0.555	0.23
119_L	211_F	0.555	0.23
82_Q	374_I	0.555	0.23
263_C	267_G	0.553	0.23
192_L	288_K	0.552	0.23
172_R	369_E	0.552	0.23
174_Y	186_E	0.552	0.23
66_T	164_G	0.549	0.23
85_L	211_F	0.548	0.23
100_A	370_I	0.546	0.23
154_F	202_I	0.546	0.23
138_F	144_N	0.545	0.23
69_R	209_P	0.545	0.23
242_Y	297_F	0.545	0.23
158_D	174_Y	0.545	0.23
172_R	347_C	0.544	0.23
45_D	128_D	0.543	0.22
58_I	283_S	0.543	0.22
69_R	130_D	0.543	0.22
106_E	364_D	0.543	0.22
287_L	315_K	0.543	0.22
89_N	211_F	0.543	0.22
87_D	92_A	0.541	0.22
98_I	227_N	0.538	0.22
153_A	222_F	0.537	0.22
147_T	202_I	0.537	0.22
64_S	76_E	0.536	0.22
59_I	358_P	0.535	0.22
217_Y	308_K	0.534	0.22
94_S	98_I	0.534	0.22
180_K	210_L	0.534	0.22
273_I	287_L	0.532	0.22
163_E	185_K	0.532	0.22
128_D	133_G	0.532	0.22
134_S	255_V	0.529	0.22
197_I	241_K	0.529	0.22
64_S	239_H	0.529	0.22
282_Y	302_S	0.528	0.22
90_P	241_K	0.527	0.22
72_R	241_K	0.526	0.22
142_S	275_P	0.526	0.22
69_R	76_E	0.525	0.22
215_A	309_L	0.523	0.21
251_F	264_P	0.523	0.21
150_G	158_D	0.523	0.21
317_A	372_K	0.523	0.21
273_I	369_E	0.522	0.21
206_T	226_E	0.522	0.21
158_D	164_G	0.522	0.21
49_I	306_I	0.521	0.21
181_L	252_Q	0.521	0.21
159_L	322_V	0.521	0.21
27_F	301_T	0.521	0.21
132_F	140_L	0.518	0.21
170_C	184_S	0.517	0.21
244_G	249_C	0.517	0.21
159_L	250_G	0.517	0.21
57_K	296_N	0.516	0.21
37_N	174_Y	0.515	0.21
260_K	270_F	0.515	0.21
351_A	362_R	0.514	0.21
154_F	228_G	0.513	0.21
129_I	368_E	0.511	0.21
54_L	224_R	0.511	0.21
225_V	288_K	0.510	0.21
277_Y	294_Y	0.510	0.21
130_D	220_R	0.510	0.21
109_K	170_C	0.509	0.21
93_T	330_A	0.508	0.21
49_I	173_K	0.508	0.21
130_D	164_G	0.506	0.21
116_N	370_I	0.504	0.20
165_S	182_S	0.504	0.20
179_H	268_E	0.503	0.20
185_K	228_G	0.503	0.20
342_E	354_T	0.503	0.20
132_F	242_Y	0.502	0.20
254_F	330_A	0.502	0.20
210_L	362_R	0.502	0.20
78_W	156_A	0.501	0.20
340_P	351_A	0.500	0.20

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2dulA	2	0.918	100	0.334	Contact Map
3axsA	2	0.963	100	0.397	Contact Map
3k6rA	1	0.5079	99.3	0.898	Contact Map
2yx1A	2	0.4894	99.2	0.901	Contact Map
1wxxA	2	0.537	99.2	0.904	Contact Map
3v97A	1	0.4894	99.2	0.904	Contact Map
3c0kA	2	0.4868	99.1	0.904	Contact Map
2igtA	4	0.5397	99.1	0.906	Contact Map
3vseA	1	0.5397	99.1	0.906	Contact Map
2b78A	1	0.5132	99.1	0.907	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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