GREMLIN Database
Q97ZG7 - Uncharacterized protein
UniProt: Q97ZG7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 355 (334)
Sequences: 221 (167)
Seq/√Len: 9.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_C71_F4.9071.00
38_A51_V4.1200.99
27_E58_T3.9270.98
13_D16_G3.8390.98
52_V130_V3.7940.98
11_I83_Q3.5950.97
12_D46_D3.2610.94
79_G82_S2.9490.90
22_T73_S2.8620.89
103_V232_G2.7640.87
225_S266_S2.7440.86
53_A69_I2.7440.86
17_D37_A2.6790.85
37_A41_M2.6500.84
7_I70_V2.5520.82
172_L200_K2.3340.75
151_K165_V2.3280.75
226_I229_L2.2850.74
27_E31_K2.2230.72
75_S81_E2.1810.70
17_D41_M2.1410.69
25_I91_D2.1070.67
162_F200_K2.0710.66
9_V70_V2.0670.66
124_I275_A2.0410.65
56_I105_V2.0170.64
235_N238_I2.0050.63
41_M143_M1.9760.62
7_I196_A1.9080.59
203_K280_L1.8920.59
112_A129_Q1.8750.58
14_D74_G1.8380.56
72_I90_L1.8300.56
15_I73_S1.8290.56
148_Y164_G1.7990.55
222_A229_L1.7880.54
27_E54_F1.7650.53
236_L242_I1.7600.53
22_T138_V1.7560.53
208_I234_I1.7300.52
14_D17_D1.7170.51
145_L191_I1.6930.50
255_I305_T1.6840.50
266_S311_I1.6590.49
58_T108_S1.6340.47
8_Y53_A1.6310.47
13_D179_L1.6170.47
259_I267_A1.5950.46
14_D46_D1.5940.46
24_I175_I1.5910.46
50_M71_F1.5890.45
6_V80_T1.5790.45
117_I130_V1.5710.45
159_A202_L1.5550.44
9_V22_T1.5390.43
53_A138_V1.5360.43
27_E37_A1.5100.42
69_I149_I1.5090.42
266_S276_I1.5040.42
59_D301_F1.5030.42
74_G107_D1.4960.41
219_V229_L1.4830.41
238_I243_V1.4820.41
78_G82_S1.4810.41
13_D17_D1.4750.41
9_V265_F1.4740.41
54_F331_V1.4710.40
129_Q167_G1.4680.40
34_L108_S1.4580.40
106_Y122_L1.4550.40
34_L37_A1.4500.40
124_I193_L1.4410.39
234_I237_Y1.4380.39
143_M151_K1.4370.39
24_I238_I1.4290.39
46_D108_S1.4280.39
7_I102_A1.4200.38
236_L239_Q1.4040.38
69_I128_Q1.4010.37
7_I200_K1.3980.37
52_V105_V1.3970.37
80_T126_A1.3940.37
121_R125_S1.3930.37
90_L206_D1.3910.37
113_R200_K1.3820.37
10_D14_D1.3760.36
39_Y105_V1.3690.36
118_I209_E1.3610.36
223_T228_S1.3530.36
17_D33_T1.3450.35
86_F231_I1.3310.35
223_T229_L1.3240.34
140_E148_Y1.3240.34
222_A227_I1.3220.34
222_A228_S1.3040.34
144_L151_K1.3010.33
51_V304_F1.2800.33
165_V305_T1.2790.33
58_T156_K1.2740.32
103_V116_P1.2700.32
37_A108_S1.2700.32
32_L36_K1.2620.32
110_D169_I1.2570.32
27_E108_S1.2550.32
296_I299_I1.2520.32
224_V227_I1.2490.31
45_S120_S1.2290.31
59_D90_L1.2240.31
22_T94_I1.2120.30
223_T233_V1.2070.30
217_I220_I1.2030.30
277_S294_I1.1980.30
199_I205_D1.1870.29
329_S332_I1.1750.29
252_F255_I1.1750.29
31_K54_F1.1710.29
252_F280_L1.1510.28
5_I70_V1.1490.28
147_K197_M1.1430.28
220_I229_L1.1420.28
118_I174_G1.1310.27
208_I283_D1.1300.27
37_A109_P1.1240.27
86_F157_R1.1180.27
140_E262_Y1.1140.27
265_F272_G1.1140.27
92_K171_A1.1130.27
146_A150_R1.1110.27
22_T80_T1.1110.27
109_P201_G1.1110.27
134_Q144_L1.1060.26
83_Q126_A1.1060.26
65_E103_V1.1020.26
94_I99_P1.0970.26
212_W220_I1.0920.26
89_K118_I1.0900.26
71_F79_G1.0870.26
164_G202_L1.0830.26
228_S232_G1.0820.26
15_I30_C1.0800.25
268_I303_L1.0790.25
101_Y125_S1.0580.25
204_I320_Q1.0550.25
84_L201_G1.0540.25
43_T151_K1.0480.24
220_I223_T1.0460.24
6_V20_F1.0400.24
5_I43_T1.0400.24
13_D33_T1.0340.24
13_D61_K1.0290.24
151_K158_Y1.0280.24
91_D121_R1.0270.24
127_V256_I1.0230.24
88_K242_I1.0200.24
37_A196_A1.0160.23
31_K191_I1.0160.23
44_D107_D1.0140.23
75_S171_A1.0060.23
22_T89_K1.0060.23
80_T266_S1.0040.23
109_P143_M1.0020.23
115_I268_I1.0000.23
228_S233_V1.0000.23
219_V222_A0.9990.23
19_G67_T0.9960.23
17_D143_M0.9940.23
143_M165_V0.9910.23
30_C72_I0.9870.23
64_G190_L0.9860.22
120_S132_V0.9850.22
109_P151_K0.9840.22
176_L263_A0.9840.22
124_I178_A0.9830.22
138_V174_G0.9790.22
254_F258_Q0.9750.22
140_E151_K0.9750.22
203_K230_L0.9740.22
222_A225_S0.9710.22
231_I256_I0.9670.22
278_K289_D0.9660.22
207_L280_L0.9560.22
17_D43_T0.9560.22
151_K164_G0.9560.22
51_V108_S0.9560.22
3_K156_K0.9550.22
137_G148_Y0.9550.22
50_M66_D0.9520.21
126_A325_L0.9510.21
18_L41_M0.9500.21
197_M239_Q0.9500.21
10_D26_G0.9490.21
28_E337_I0.9480.21
36_K61_K0.9460.21
138_V148_Y0.9460.21
11_I126_A0.9460.21
151_K262_Y0.9450.21
173_A196_A0.9440.21
4_T125_S0.9430.21
116_P120_S0.9400.21
45_S82_S0.9380.21
39_Y200_K0.9360.21
18_L37_A0.9300.21
276_I289_D0.9290.21
28_E73_S0.9280.21
109_P165_V0.9280.21
14_D44_D0.9260.21
190_L204_I0.9260.21
22_T97_L0.9240.21
188_T206_D0.9240.21
38_A47_F0.9230.21
56_I59_D0.9220.21
9_V234_I0.9180.20
144_L148_Y0.9140.20
146_A161_V0.9140.20
33_T124_I0.9090.20
193_L220_I0.9080.20
21_S237_Y0.9070.20
198_V273_G0.8990.20
52_V69_I0.8980.20
127_V159_A0.8980.20
9_V296_I0.8970.20
106_Y187_P0.8950.20
23_P111_D0.8910.20
206_D327_L0.8870.20
6_V19_G0.8850.20
12_D53_A0.8850.20
61_K124_I0.8840.20
20_F50_M0.8820.19
129_Q146_A0.8810.19
45_S74_G0.8760.19
41_M151_K0.8750.19
82_S135_Y0.8750.19
47_F228_S0.8730.19
151_K305_T0.8730.19
203_K294_I0.8720.19
46_D81_E0.8710.19
12_D108_S0.8690.19
126_A202_L0.8660.19
137_G201_G0.8610.19
34_L51_V0.8590.19
140_E164_G0.8590.19
88_K321_S0.8560.19
165_V300_Y0.8530.19
99_P272_G0.8420.18
266_S307_V0.8410.18
115_I303_L0.8400.18
12_D57_Y0.8390.18
137_G164_G0.8390.18
145_L196_A0.8360.18
89_K110_D0.8360.18
165_V262_Y0.8350.18
277_S298_I0.8320.18
224_V337_I0.8320.18
16_G37_A0.8310.18
6_V276_I0.8300.18
9_V79_G0.8240.18
330_I333_I0.8230.18
197_M241_Q0.8220.18
82_S89_K0.8220.18
18_L72_I0.8150.18
88_K103_V0.8140.18
46_D74_G0.8120.18
140_E143_M0.8110.18
16_G33_T0.8090.18
24_I268_I0.8090.18
320_Q327_L0.8050.17
114_A226_I0.8050.17
117_I189_I0.8040.17
272_G326_I0.8020.17
148_Y165_V0.8020.17
316_I322_L0.8020.17
190_L225_S0.8000.17
89_K140_E0.7980.17
238_I298_I0.7980.17
97_L127_V0.7920.17
57_Y73_S0.7910.17
255_I303_L0.7900.17
161_V266_S0.7890.17
30_C176_L0.7890.17
41_M109_P0.7850.17
28_E298_I0.7840.17
29_K221_T0.7820.17
78_G110_D0.7790.17
59_D64_G0.7770.17
255_I298_I0.7750.17
53_A265_F0.7750.17
225_S339_L0.7730.17
143_M196_A0.7700.17
86_F224_V0.7690.17
53_A94_I0.7660.16
68_E204_I0.7660.16
278_K310_I0.7630.16
166_P204_I0.7630.16
69_I114_A0.7610.16
14_D37_A0.7590.16
325_L339_L0.7570.16
7_I49_S0.7570.16
240_L297_V0.7560.16
117_I281_N0.7550.16
129_Q134_Q0.7550.16
176_L261_P0.7510.16
9_V124_I0.7500.16
189_I298_I0.7490.16
136_R286_V0.7490.16
53_A83_Q0.7430.16
106_Y216_T0.7420.16
103_V168_I0.7410.16
277_S300_Y0.7410.16
167_G201_G0.7410.16
234_I337_I0.7410.16
151_K161_V0.7400.16
117_I162_F0.7320.16
34_L156_K0.7310.16
14_D107_D0.7300.16
11_I43_T0.7300.16
16_G46_D0.7290.16
80_T129_Q0.7280.16
260_L315_Y0.7270.16
53_A232_G0.7230.15
47_F202_L0.7220.15
62_R274_K0.7220.15
6_V22_T0.7220.15
245_G256_I0.7210.15
30_C78_G0.7200.15
7_I14_D0.7190.15
88_K92_K0.7170.15
118_I160_R0.7160.15
179_L302_I0.7150.15
24_I293_I0.7090.15
164_G199_I0.7080.15
86_F178_A0.7070.15
111_D116_P0.7040.15
125_S165_V0.7030.15
221_T233_V0.7030.15
237_Y244_R0.7030.15
14_D19_G0.7010.15
11_I53_A0.6970.15
135_Y159_A0.6920.15
34_L58_T0.6900.15
174_G235_N0.6890.15
136_R144_L0.6880.15
64_G177_A0.6870.15
24_I208_I0.6870.15
17_D40_F0.6840.15
46_D107_D0.6840.15
280_L290_I0.6820.15
310_I324_T0.6820.15
87_S262_Y0.6800.15
140_E165_V0.6800.15
82_S166_P0.6790.14
232_G237_Y0.6770.14
115_I260_L0.6760.14
179_L254_F0.6720.14
53_A263_A0.6720.14
211_W237_Y0.6710.14
235_N239_Q0.6710.14
37_A58_T0.6670.14
126_A164_G0.6670.14
59_D63_K0.6660.14
54_F77_K0.6660.14
17_D196_A0.6640.14
15_I27_E0.6620.14
84_L259_I0.6620.14
236_L247_S0.6610.14
84_L293_I0.6600.14
245_G254_F0.6600.14
24_I322_L0.6580.14
91_D225_S0.6570.14
250_Q318_T0.6560.14
57_Y66_D0.6550.14
59_D167_G0.6540.14
166_P180_N0.6540.14
98_S117_I0.6530.14
217_I223_T0.6520.14
245_G282_R0.6510.14
19_G122_L0.6500.14
117_I296_I0.6500.14
58_T212_W0.6490.14
249_I330_I0.6480.14
21_S204_I0.6480.14
144_L279_G0.6470.14
62_R203_K0.6460.14
7_I205_D0.6460.14
94_I138_V0.6440.14
257_L308_K0.6410.14
66_D243_V0.6410.14
46_D57_Y0.6410.14
239_Q290_I0.6370.14
237_Y241_Q0.6350.14
106_Y157_R0.6350.14
115_I196_A0.6320.14
16_G194_G0.6300.13
67_T114_A0.6300.13
6_V297_V0.6290.13
30_C37_A0.6290.13
28_E94_I0.6260.13
27_E112_A0.6260.13
94_I122_L0.6260.13
9_V14_D0.6260.13
73_S93_V0.6250.13
24_I77_K0.6180.13
70_V114_A0.6160.13
105_V308_K0.6150.13
130_V186_E0.6150.13
232_G299_I0.6120.13
221_T336_Y0.6110.13
56_I301_F0.6050.13
269_I302_I0.6040.13
59_D261_P0.6030.13
12_D33_T0.6010.13
34_L47_F0.6010.13
245_G252_F0.5990.13
138_V295_N0.5980.13
319_F322_L0.5980.13
161_V192_I0.5980.13
51_V288_H0.5970.13
130_V167_G0.5960.13
45_S196_A0.5950.13
3_K266_S0.5950.13
90_L312_D0.5920.13
148_Y166_P0.5910.13
262_Y311_I0.5890.13
83_Q219_V0.5890.13
51_V148_Y0.5880.13
258_Q330_I0.5880.13
130_V264_S0.5870.13
72_I118_I0.5860.13
165_V198_V0.5860.13
55_N58_T0.5840.13
13_D74_G0.5840.13
39_Y88_K0.5830.13
229_L266_S0.5830.13
109_P117_I0.5820.13
19_G224_V0.5820.13
104_V202_L0.5810.12
24_I96_E0.5790.12
164_G201_G0.5790.12
227_I233_V0.5780.12
45_S132_V0.5770.12
38_A225_S0.5770.12
231_I296_I0.5760.12
161_V165_V0.5750.12
20_F111_D0.5750.12
136_R196_A0.5740.12
9_V53_A0.5740.12
30_C82_S0.5710.12
102_A191_I0.5710.12
193_L219_V0.5710.12
102_A151_K0.5700.12
35_D50_M0.5700.12
160_R203_K0.5670.12
175_I327_L0.5650.12
58_T134_Q0.5640.12
174_G277_S0.5640.12
163_L302_I0.5610.12
326_I329_S0.5590.12
80_T112_A0.5590.12
45_S118_I0.5590.12
336_Y340_T0.5580.12
68_E106_Y0.5570.12
14_D22_T0.5550.12
6_V73_S0.5520.12
229_L233_V0.5520.12
142_Y171_A0.5510.12
110_D139_E0.5480.12
138_V200_K0.5480.12
230_L314_T0.5470.12
15_I86_F0.5470.12
15_I71_F0.5460.12
8_Y273_G0.5460.12
24_I92_K0.5450.12
39_Y52_V0.5440.12
226_I231_I0.5430.12
209_E281_N0.5420.12
281_N299_I0.5420.12
17_D79_G0.5350.12
216_T259_I0.5350.12
164_G262_Y0.5330.12
45_S173_A0.5320.12
85_E88_K0.5300.12
63_K234_I0.5290.12
182_S205_D0.5270.11
14_D139_E0.5270.11
15_I61_K0.5260.11
110_D158_Y0.5230.11
256_I302_I0.5210.11
177_A231_I0.5190.11
65_E299_I0.5190.11
67_T145_L0.5190.11
102_A114_A0.5160.11
9_V12_D0.5160.11
159_A200_K0.5130.11
88_K249_I0.5120.11
57_Y188_T0.5110.11
38_A258_Q0.5080.11
5_I69_I0.5060.11
100_E335_I0.5050.11
65_E69_I0.5040.11
88_K168_I0.5030.11
327_L333_I0.5010.11
163_L169_I0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1mhsA 2 0.8901 62.7 0.967 Contact Map
1e2bA 1 0.2535 46.3 0.97 Contact Map
3ij5A 4 0.4056 43 0.971 Contact Map
1fvpA 2 0.262 40.2 0.971 Contact Map
2p9jA 5 0.3718 33 0.973 Contact Map
3c8nA 2 0.2704 33 0.973 Contact Map
2wm8A 1 0.3831 32.5 0.973 Contact Map
4j29A 2 0.1493 32.1 0.973 Contact Map
4ezeA 1 0.4056 30.8 0.973 Contact Map
3ewiA 3 0.3662 29.7 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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