Q97ZG7 - SULSO - GREMLIN Contacts

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Q97ZG7 - Uncharacterized protein

UniProt:	Q97ZG7	Sequences: MVKTIVIYVDIDDDIGDLGFSTPIIGEEKCKLTLDKAAYFMPTDSDFNSMVVAFNIYTDLKRKGEDTEIVFISGSKKGGTESQLEFSKKLDKVIEELSPEYAVVVYDSPDDARAIPIIQSRLKISAVQQVIVEQYRGVEETYMLLAKYIRKAVTEKRYARVFLGVPGIILALAGILAALNLSVYIEPTILIILGVAMVIKGLKIDDLIESWWENSTIMVITATVSIISLLIGVINLYIQLQIVRGLSSIQEFAFIILQILPYASFSAIILFGGKAISKGLNRDIRVWHDIIKIINIVIIYFILFTVVKDIIDNTYILTFQSLYTLILASIVIISIYITLTALEKYGILEKLIKRI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	355 (334)
Sequences:	221 (167)
Seq/√Len:	9.1

HALSA - Q9HS59 Q9HNC9
SULSO - Q97ZG7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
30_C	71_F	4.907	1.00
38_A	51_V	4.120	0.99
27_E	58_T	3.927	0.98
13_D	16_G	3.839	0.98
52_V	130_V	3.794	0.98
11_I	83_Q	3.595	0.97
12_D	46_D	3.261	0.94
79_G	82_S	2.949	0.90
22_T	73_S	2.862	0.89
103_V	232_G	2.764	0.87
225_S	266_S	2.744	0.86
53_A	69_I	2.744	0.86
17_D	37_A	2.679	0.85
37_A	41_M	2.650	0.84
7_I	70_V	2.552	0.82
172_L	200_K	2.334	0.75
151_K	165_V	2.328	0.75
226_I	229_L	2.285	0.74
27_E	31_K	2.223	0.72
75_S	81_E	2.181	0.70
17_D	41_M	2.141	0.69
25_I	91_D	2.107	0.67
162_F	200_K	2.071	0.66
9_V	70_V	2.067	0.66
124_I	275_A	2.041	0.65
56_I	105_V	2.017	0.64
235_N	238_I	2.005	0.63
41_M	143_M	1.976	0.62
7_I	196_A	1.908	0.59
203_K	280_L	1.892	0.59
112_A	129_Q	1.875	0.58
14_D	74_G	1.838	0.56
72_I	90_L	1.830	0.56
15_I	73_S	1.829	0.56
148_Y	164_G	1.799	0.55
222_A	229_L	1.788	0.54
27_E	54_F	1.765	0.53
236_L	242_I	1.760	0.53
22_T	138_V	1.756	0.53
208_I	234_I	1.730	0.52
14_D	17_D	1.717	0.51
145_L	191_I	1.693	0.50
255_I	305_T	1.684	0.50
266_S	311_I	1.659	0.49
58_T	108_S	1.634	0.47
8_Y	53_A	1.631	0.47
13_D	179_L	1.617	0.47
259_I	267_A	1.595	0.46
14_D	46_D	1.594	0.46
24_I	175_I	1.591	0.46
50_M	71_F	1.589	0.45
6_V	80_T	1.579	0.45
117_I	130_V	1.571	0.45
159_A	202_L	1.555	0.44
9_V	22_T	1.539	0.43
53_A	138_V	1.536	0.43
27_E	37_A	1.510	0.42
69_I	149_I	1.509	0.42
266_S	276_I	1.504	0.42
59_D	301_F	1.503	0.42
74_G	107_D	1.496	0.41
219_V	229_L	1.483	0.41
238_I	243_V	1.482	0.41
78_G	82_S	1.481	0.41
13_D	17_D	1.475	0.41
9_V	265_F	1.474	0.41
54_F	331_V	1.471	0.40
129_Q	167_G	1.468	0.40
34_L	108_S	1.458	0.40
106_Y	122_L	1.455	0.40
34_L	37_A	1.450	0.40
124_I	193_L	1.441	0.39
234_I	237_Y	1.438	0.39
143_M	151_K	1.437	0.39
24_I	238_I	1.429	0.39
46_D	108_S	1.428	0.39
7_I	102_A	1.420	0.38
236_L	239_Q	1.404	0.38
69_I	128_Q	1.401	0.37
7_I	200_K	1.398	0.37
52_V	105_V	1.397	0.37
80_T	126_A	1.394	0.37
121_R	125_S	1.393	0.37
90_L	206_D	1.391	0.37
113_R	200_K	1.382	0.37
10_D	14_D	1.376	0.36
39_Y	105_V	1.369	0.36
118_I	209_E	1.361	0.36
223_T	228_S	1.353	0.36
17_D	33_T	1.345	0.35
86_F	231_I	1.331	0.35
223_T	229_L	1.324	0.34
140_E	148_Y	1.324	0.34
222_A	227_I	1.322	0.34
222_A	228_S	1.304	0.34
144_L	151_K	1.301	0.33
51_V	304_F	1.280	0.33
165_V	305_T	1.279	0.33
58_T	156_K	1.274	0.32
103_V	116_P	1.270	0.32
37_A	108_S	1.270	0.32
32_L	36_K	1.262	0.32
110_D	169_I	1.257	0.32
27_E	108_S	1.255	0.32
296_I	299_I	1.252	0.32
224_V	227_I	1.249	0.31
45_S	120_S	1.229	0.31
59_D	90_L	1.224	0.31
22_T	94_I	1.212	0.30
223_T	233_V	1.207	0.30
217_I	220_I	1.203	0.30
277_S	294_I	1.198	0.30
199_I	205_D	1.187	0.29
329_S	332_I	1.175	0.29
252_F	255_I	1.175	0.29
31_K	54_F	1.171	0.29
252_F	280_L	1.151	0.28
5_I	70_V	1.149	0.28
147_K	197_M	1.143	0.28
220_I	229_L	1.142	0.28
118_I	174_G	1.131	0.27
208_I	283_D	1.130	0.27
37_A	109_P	1.124	0.27
86_F	157_R	1.118	0.27
140_E	262_Y	1.114	0.27
265_F	272_G	1.114	0.27
92_K	171_A	1.113	0.27
146_A	150_R	1.111	0.27
22_T	80_T	1.111	0.27
109_P	201_G	1.111	0.27
134_Q	144_L	1.106	0.26
83_Q	126_A	1.106	0.26
65_E	103_V	1.102	0.26
94_I	99_P	1.097	0.26
212_W	220_I	1.092	0.26
89_K	118_I	1.090	0.26
71_F	79_G	1.087	0.26
164_G	202_L	1.083	0.26
228_S	232_G	1.082	0.26
15_I	30_C	1.080	0.25
268_I	303_L	1.079	0.25
101_Y	125_S	1.058	0.25
204_I	320_Q	1.055	0.25
84_L	201_G	1.054	0.25
43_T	151_K	1.048	0.24
220_I	223_T	1.046	0.24
6_V	20_F	1.040	0.24
5_I	43_T	1.040	0.24
13_D	33_T	1.034	0.24
13_D	61_K	1.029	0.24
151_K	158_Y	1.028	0.24
91_D	121_R	1.027	0.24
127_V	256_I	1.023	0.24
88_K	242_I	1.020	0.24
37_A	196_A	1.016	0.23
31_K	191_I	1.016	0.23
44_D	107_D	1.014	0.23
75_S	171_A	1.006	0.23
22_T	89_K	1.006	0.23
80_T	266_S	1.004	0.23
109_P	143_M	1.002	0.23
115_I	268_I	1.000	0.23
228_S	233_V	1.000	0.23
219_V	222_A	0.999	0.23
19_G	67_T	0.996	0.23
17_D	143_M	0.994	0.23
143_M	165_V	0.991	0.23
30_C	72_I	0.987	0.23
64_G	190_L	0.986	0.22
120_S	132_V	0.985	0.22
109_P	151_K	0.984	0.22
176_L	263_A	0.984	0.22
124_I	178_A	0.983	0.22
138_V	174_G	0.979	0.22
254_F	258_Q	0.975	0.22
140_E	151_K	0.975	0.22
203_K	230_L	0.974	0.22
222_A	225_S	0.971	0.22
231_I	256_I	0.967	0.22
278_K	289_D	0.966	0.22
207_L	280_L	0.956	0.22
17_D	43_T	0.956	0.22
151_K	164_G	0.956	0.22
51_V	108_S	0.956	0.22
3_K	156_K	0.955	0.22
137_G	148_Y	0.955	0.22
50_M	66_D	0.952	0.21
126_A	325_L	0.951	0.21
18_L	41_M	0.950	0.21
197_M	239_Q	0.950	0.21
10_D	26_G	0.949	0.21
28_E	337_I	0.948	0.21
36_K	61_K	0.946	0.21
138_V	148_Y	0.946	0.21
11_I	126_A	0.946	0.21
151_K	262_Y	0.945	0.21
173_A	196_A	0.944	0.21
4_T	125_S	0.943	0.21
116_P	120_S	0.940	0.21
45_S	82_S	0.938	0.21
39_Y	200_K	0.936	0.21
18_L	37_A	0.930	0.21
276_I	289_D	0.929	0.21
28_E	73_S	0.928	0.21
109_P	165_V	0.928	0.21
14_D	44_D	0.926	0.21
190_L	204_I	0.926	0.21
22_T	97_L	0.924	0.21
188_T	206_D	0.924	0.21
38_A	47_F	0.923	0.21
56_I	59_D	0.922	0.21
9_V	234_I	0.918	0.20
144_L	148_Y	0.914	0.20
146_A	161_V	0.914	0.20
33_T	124_I	0.909	0.20
193_L	220_I	0.908	0.20
21_S	237_Y	0.907	0.20
198_V	273_G	0.899	0.20
52_V	69_I	0.898	0.20
127_V	159_A	0.898	0.20
9_V	296_I	0.897	0.20
106_Y	187_P	0.895	0.20
23_P	111_D	0.891	0.20
206_D	327_L	0.887	0.20
6_V	19_G	0.885	0.20
12_D	53_A	0.885	0.20
61_K	124_I	0.884	0.20
20_F	50_M	0.882	0.19
129_Q	146_A	0.881	0.19
45_S	74_G	0.876	0.19
41_M	151_K	0.875	0.19
82_S	135_Y	0.875	0.19
47_F	228_S	0.873	0.19
151_K	305_T	0.873	0.19
203_K	294_I	0.872	0.19
46_D	81_E	0.871	0.19
12_D	108_S	0.869	0.19
126_A	202_L	0.866	0.19
137_G	201_G	0.861	0.19
34_L	51_V	0.859	0.19
140_E	164_G	0.859	0.19
88_K	321_S	0.856	0.19
165_V	300_Y	0.853	0.19
99_P	272_G	0.842	0.18
266_S	307_V	0.841	0.18
115_I	303_L	0.840	0.18
12_D	57_Y	0.839	0.18
137_G	164_G	0.839	0.18
145_L	196_A	0.836	0.18
89_K	110_D	0.836	0.18
165_V	262_Y	0.835	0.18
277_S	298_I	0.832	0.18
224_V	337_I	0.832	0.18
16_G	37_A	0.831	0.18
6_V	276_I	0.830	0.18
9_V	79_G	0.824	0.18
330_I	333_I	0.823	0.18
197_M	241_Q	0.822	0.18
82_S	89_K	0.822	0.18
18_L	72_I	0.815	0.18
88_K	103_V	0.814	0.18
46_D	74_G	0.812	0.18
140_E	143_M	0.811	0.18
16_G	33_T	0.809	0.18
24_I	268_I	0.809	0.18
320_Q	327_L	0.805	0.17
114_A	226_I	0.805	0.17
117_I	189_I	0.804	0.17
272_G	326_I	0.802	0.17
148_Y	165_V	0.802	0.17
316_I	322_L	0.802	0.17
190_L	225_S	0.800	0.17
89_K	140_E	0.798	0.17
238_I	298_I	0.798	0.17
97_L	127_V	0.792	0.17
57_Y	73_S	0.791	0.17
255_I	303_L	0.790	0.17
161_V	266_S	0.789	0.17
30_C	176_L	0.789	0.17
41_M	109_P	0.785	0.17
28_E	298_I	0.784	0.17
29_K	221_T	0.782	0.17
78_G	110_D	0.779	0.17
59_D	64_G	0.777	0.17
255_I	298_I	0.775	0.17
53_A	265_F	0.775	0.17
225_S	339_L	0.773	0.17
143_M	196_A	0.770	0.17
86_F	224_V	0.769	0.17
53_A	94_I	0.766	0.16
68_E	204_I	0.766	0.16
278_K	310_I	0.763	0.16
166_P	204_I	0.763	0.16
69_I	114_A	0.761	0.16
14_D	37_A	0.759	0.16
325_L	339_L	0.757	0.16
7_I	49_S	0.757	0.16
240_L	297_V	0.756	0.16
117_I	281_N	0.755	0.16
129_Q	134_Q	0.755	0.16
176_L	261_P	0.751	0.16
9_V	124_I	0.750	0.16
189_I	298_I	0.749	0.16
136_R	286_V	0.749	0.16
53_A	83_Q	0.743	0.16
106_Y	216_T	0.742	0.16
103_V	168_I	0.741	0.16
277_S	300_Y	0.741	0.16
167_G	201_G	0.741	0.16
234_I	337_I	0.741	0.16
151_K	161_V	0.740	0.16
117_I	162_F	0.732	0.16
34_L	156_K	0.731	0.16
14_D	107_D	0.730	0.16
11_I	43_T	0.730	0.16
16_G	46_D	0.729	0.16
80_T	129_Q	0.728	0.16
260_L	315_Y	0.727	0.16
53_A	232_G	0.723	0.15
47_F	202_L	0.722	0.15
62_R	274_K	0.722	0.15
6_V	22_T	0.722	0.15
245_G	256_I	0.721	0.15
30_C	78_G	0.720	0.15
7_I	14_D	0.719	0.15
88_K	92_K	0.717	0.15
118_I	160_R	0.716	0.15
179_L	302_I	0.715	0.15
24_I	293_I	0.709	0.15
164_G	199_I	0.708	0.15
86_F	178_A	0.707	0.15
111_D	116_P	0.704	0.15
125_S	165_V	0.703	0.15
221_T	233_V	0.703	0.15
237_Y	244_R	0.703	0.15
14_D	19_G	0.701	0.15
11_I	53_A	0.697	0.15
135_Y	159_A	0.692	0.15
34_L	58_T	0.690	0.15
174_G	235_N	0.689	0.15
136_R	144_L	0.688	0.15
64_G	177_A	0.687	0.15
24_I	208_I	0.687	0.15
17_D	40_F	0.684	0.15
46_D	107_D	0.684	0.15
280_L	290_I	0.682	0.15
310_I	324_T	0.682	0.15
87_S	262_Y	0.680	0.15
140_E	165_V	0.680	0.15
82_S	166_P	0.679	0.14
232_G	237_Y	0.677	0.14
115_I	260_L	0.676	0.14
179_L	254_F	0.672	0.14
53_A	263_A	0.672	0.14
211_W	237_Y	0.671	0.14
235_N	239_Q	0.671	0.14
37_A	58_T	0.667	0.14
126_A	164_G	0.667	0.14
59_D	63_K	0.666	0.14
54_F	77_K	0.666	0.14
17_D	196_A	0.664	0.14
15_I	27_E	0.662	0.14
84_L	259_I	0.662	0.14
236_L	247_S	0.661	0.14
84_L	293_I	0.660	0.14
245_G	254_F	0.660	0.14
24_I	322_L	0.658	0.14
91_D	225_S	0.657	0.14
250_Q	318_T	0.656	0.14
57_Y	66_D	0.655	0.14
59_D	167_G	0.654	0.14
166_P	180_N	0.654	0.14
98_S	117_I	0.653	0.14
217_I	223_T	0.652	0.14
245_G	282_R	0.651	0.14
19_G	122_L	0.650	0.14
117_I	296_I	0.650	0.14
58_T	212_W	0.649	0.14
249_I	330_I	0.648	0.14
21_S	204_I	0.648	0.14
144_L	279_G	0.647	0.14
62_R	203_K	0.646	0.14
7_I	205_D	0.646	0.14
94_I	138_V	0.644	0.14
257_L	308_K	0.641	0.14
66_D	243_V	0.641	0.14
46_D	57_Y	0.641	0.14
239_Q	290_I	0.637	0.14
237_Y	241_Q	0.635	0.14
106_Y	157_R	0.635	0.14
115_I	196_A	0.632	0.14
16_G	194_G	0.630	0.13
67_T	114_A	0.630	0.13
6_V	297_V	0.629	0.13
30_C	37_A	0.629	0.13
28_E	94_I	0.626	0.13
27_E	112_A	0.626	0.13
94_I	122_L	0.626	0.13
9_V	14_D	0.626	0.13
73_S	93_V	0.625	0.13
24_I	77_K	0.618	0.13
70_V	114_A	0.616	0.13
105_V	308_K	0.615	0.13
130_V	186_E	0.615	0.13
232_G	299_I	0.612	0.13
221_T	336_Y	0.611	0.13
56_I	301_F	0.605	0.13
269_I	302_I	0.604	0.13
59_D	261_P	0.603	0.13
12_D	33_T	0.601	0.13
34_L	47_F	0.601	0.13
245_G	252_F	0.599	0.13
138_V	295_N	0.598	0.13
319_F	322_L	0.598	0.13
161_V	192_I	0.598	0.13
51_V	288_H	0.597	0.13
130_V	167_G	0.596	0.13
45_S	196_A	0.595	0.13
3_K	266_S	0.595	0.13
90_L	312_D	0.592	0.13
148_Y	166_P	0.591	0.13
262_Y	311_I	0.589	0.13
83_Q	219_V	0.589	0.13
51_V	148_Y	0.588	0.13
258_Q	330_I	0.588	0.13
130_V	264_S	0.587	0.13
72_I	118_I	0.586	0.13
165_V	198_V	0.586	0.13
55_N	58_T	0.584	0.13
13_D	74_G	0.584	0.13
39_Y	88_K	0.583	0.13
229_L	266_S	0.583	0.13
109_P	117_I	0.582	0.13
19_G	224_V	0.582	0.13
104_V	202_L	0.581	0.12
24_I	96_E	0.579	0.12
164_G	201_G	0.579	0.12
227_I	233_V	0.578	0.12
45_S	132_V	0.577	0.12
38_A	225_S	0.577	0.12
231_I	296_I	0.576	0.12
161_V	165_V	0.575	0.12
20_F	111_D	0.575	0.12
136_R	196_A	0.574	0.12
9_V	53_A	0.574	0.12
30_C	82_S	0.571	0.12
102_A	191_I	0.571	0.12
193_L	219_V	0.571	0.12
102_A	151_K	0.570	0.12
35_D	50_M	0.570	0.12
160_R	203_K	0.567	0.12
175_I	327_L	0.565	0.12
58_T	134_Q	0.564	0.12
174_G	277_S	0.564	0.12
163_L	302_I	0.561	0.12
326_I	329_S	0.559	0.12
80_T	112_A	0.559	0.12
45_S	118_I	0.559	0.12
336_Y	340_T	0.558	0.12
68_E	106_Y	0.557	0.12
14_D	22_T	0.555	0.12
6_V	73_S	0.552	0.12
229_L	233_V	0.552	0.12
142_Y	171_A	0.551	0.12
110_D	139_E	0.548	0.12
138_V	200_K	0.548	0.12
230_L	314_T	0.547	0.12
15_I	86_F	0.547	0.12
15_I	71_F	0.546	0.12
8_Y	273_G	0.546	0.12
24_I	92_K	0.545	0.12
39_Y	52_V	0.544	0.12
226_I	231_I	0.543	0.12
209_E	281_N	0.542	0.12
281_N	299_I	0.542	0.12
17_D	79_G	0.535	0.12
216_T	259_I	0.535	0.12
164_G	262_Y	0.533	0.12
45_S	173_A	0.532	0.12
85_E	88_K	0.530	0.12
63_K	234_I	0.529	0.12
182_S	205_D	0.527	0.11
14_D	139_E	0.527	0.11
15_I	61_K	0.526	0.11
110_D	158_Y	0.523	0.11
256_I	302_I	0.521	0.11
177_A	231_I	0.519	0.11
65_E	299_I	0.519	0.11
67_T	145_L	0.519	0.11
102_A	114_A	0.516	0.11
9_V	12_D	0.516	0.11
159_A	200_K	0.513	0.11
88_K	249_I	0.512	0.11
57_Y	188_T	0.511	0.11
38_A	258_Q	0.508	0.11
5_I	69_I	0.506	0.11
100_E	335_I	0.505	0.11
65_E	69_I	0.504	0.11
88_K	168_I	0.503	0.11
327_L	333_I	0.501	0.11
163_L	169_I	0.500	0.11

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1mhsA	2	0.8901	62.7	0.967	Contact Map
1e2bA	1	0.2535	46.3	0.97	Contact Map
3ij5A	4	0.4056	43	0.971	Contact Map
1fvpA	2	0.262	40.2	0.971	Contact Map
2p9jA	5	0.3718	33	0.973	Contact Map
3c8nA	2	0.2704	33	0.973	Contact Map
2wm8A	1	0.3831	32.5	0.973	Contact Map
4j29A	2	0.1493	32.1	0.973	Contact Map
4ezeA	1	0.4056	30.8	0.973	Contact Map
3ewiA	3	0.3662	29.7	0.973	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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