GREMLIN Database
Q97ZG6 - Uncharacterized protein
UniProt: Q97ZG6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 286 (255)
Sequences: 2596 (1973)
Seq/√Len: 123.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_D27_K4.9031.00
68_S104_V3.3471.00
256_V260_K3.3211.00
154_E222_N2.8591.00
112_K128_D2.7891.00
122_S136_G2.7251.00
150_W223_C2.5751.00
135_K234_V2.5581.00
155_F205_L2.5271.00
224_M228_S2.4091.00
225_S262_E2.4071.00
158_E215_K2.3801.00
73_D100_H2.3141.00
82_K86_Y2.3121.00
54_I58_F2.2291.00
128_D131_Q2.1881.00
170_R213_N2.1751.00
154_E157_H2.1601.00
150_W154_E2.1381.00
151_L219_I2.1171.00
32_Y54_I2.0291.00
124_V230_L2.0281.00
116_T124_V2.0071.00
175_F207_N1.9581.00
102_A123_I1.9351.00
171_S208_A1.9201.00
151_L223_C1.8951.00
21_F31_Q1.8861.00
126_G238_V1.8801.00
30_R58_F1.8771.00
151_L249_M1.8761.00
180_T183_D1.8361.00
11_I67_I1.8181.00
118_A227_F1.7851.00
123_I134_I1.7791.00
179_K183_D1.7721.00
13_A37_A1.7701.00
142_V160_L1.7691.00
148_G249_M1.7271.00
38_S70_A1.7161.00
221_N258_F1.7101.00
20_V54_I1.6991.00
13_A69_L1.6901.00
206_L220_L1.6661.00
148_G206_L1.6581.00
116_T227_F1.6261.00
79_K83_G1.5981.00
140_W195_P1.5981.00
226_E229_T1.5841.00
257_S261_R1.5821.00
66_A99_E1.5721.00
249_M255_Y1.5701.00
22_V62_F1.5381.00
156_L160_L1.5201.00
116_T231_V1.5081.00
32_Y58_F1.4941.00
217_I221_N1.4841.00
53_N57_I1.4821.00
9_L55_V1.4751.00
188_L198_I1.4591.00
109_N244_Y1.4561.00
64_R95_K1.4501.00
72_I98_I1.4301.00
105_V115_I1.4291.00
253_P257_S1.4101.00
52_S56_S1.4081.00
151_L205_L1.4071.00
158_E219_I1.3981.00
46_K49_L1.3931.00
218_R222_N1.3821.00
124_V234_V1.3711.00
19_K33_K1.3551.00
167_S170_R1.3431.00
112_K129_G1.3181.00
49_L53_N1.3071.00
145_I157_H1.3051.00
114_C243_V1.2951.00
117_I123_I1.2721.00
203_V207_N1.2631.00
34_Y54_I1.2611.00
9_L22_V1.2541.00
48_V52_S1.2521.00
120_T199_A1.2491.00
140_W149_F1.2430.99
99_E103_H1.2410.99
16_T120_T1.2160.99
9_L65_I1.2110.99
262_E265_K1.2080.99
23_H28_I1.2080.99
138_R164_Q1.2080.99
162_E170_R1.1990.99
209_I212_N1.1950.99
35_E50_R1.1910.99
149_F198_I1.1850.99
187_F191_N1.1840.99
124_V135_K1.1790.99
116_T230_L1.1780.99
118_A146_C1.1770.99
176_S201_F1.1760.99
159_L173_T1.1690.99
15_G38_S1.1600.99
136_G230_L1.1570.99
208_A216_A1.1540.99
169_D173_T1.1520.99
153_R157_H1.1350.99
43_G46_K1.1300.99
232_Q266_K1.1160.99
248_G252_S1.1070.99
20_V32_Y1.1050.99
158_E218_R1.0940.99
163_F181_E1.0870.99
54_I57_I1.0860.99
224_M258_F1.0840.99
46_K50_R1.0820.99
17_S33_K1.0800.99
167_S213_N1.0780.99
158_E167_S1.0780.99
105_V117_I1.0730.98
222_N225_S1.0670.98
114_C231_V1.0660.98
13_A18_T1.0620.98
104_V108_S1.0540.98
166_L233_M1.0510.98
208_A212_N1.0500.98
221_N262_E1.0440.98
75_E78_A1.0420.98
47_S50_R1.0400.98
245_Y259_F1.0360.98
150_W226_E1.0290.98
197_K200_Q1.0220.98
228_S263_L1.0160.98
250_Y259_F1.0110.98
44_P80_E1.0020.98
15_G20_V0.9960.98
68_S137_D0.9930.97
205_L216_A0.9920.97
105_V246_F0.9910.97
202_S205_L0.9860.97
248_G251_E0.9830.97
209_I220_L0.9760.97
223_C226_E0.9740.97
73_D77_M0.9710.97
157_H161_R0.9630.97
75_E79_K0.9600.97
116_T259_F0.9580.97
50_R54_I0.9500.97
15_G70_A0.9480.97
258_F262_E0.9480.97
35_E54_I0.9440.97
224_M259_F0.9360.96
206_L249_M0.9320.96
149_F195_P0.9290.96
65_I89_L0.9270.96
149_F199_A0.9270.96
16_T196_A0.9250.96
148_G152_G0.9210.96
200_Q203_V0.9160.96
15_G120_T0.9160.96
178_F184_L0.9120.96
74_S77_M0.9050.96
165_G233_M0.9040.96
32_Y50_R0.9040.96
28_I31_Q0.9010.96
83_G87_P0.8950.95
66_A104_V0.8900.95
228_S262_E0.8820.95
186_R191_N0.8770.95
156_L198_I0.8760.95
9_L62_F0.8760.95
20_V34_Y0.8700.95
249_M252_S0.8700.95
122_S145_I0.8670.95
177_T183_D0.8670.95
124_V143_G0.8660.94
84_Q87_P0.8640.94
8_Y64_R0.8640.94
162_E173_T0.8630.94
139_G143_G0.8630.94
106_L127_F0.8550.94
100_H123_I0.8530.94
127_F132_R0.8470.94
262_E266_K0.8470.94
167_S215_K0.8400.94
159_L213_N0.8380.93
181_E185_V0.8360.93
221_N261_R0.8360.93
166_L170_R0.8330.93
10_L64_R0.8290.93
34_Y50_R0.8280.93
11_I20_V0.8250.93
122_S147_S0.8240.93
50_R53_N0.8170.93
22_V58_F0.8120.92
138_R160_L0.8110.92
16_T248_G0.8100.92
118_A250_Y0.8090.92
224_M255_Y0.8080.92
140_W153_R0.8050.92
259_F263_L0.8020.92
222_N226_E0.7990.92
169_D174_Q0.7980.92
39_V77_M0.7930.91
148_G199_A0.7910.91
37_A47_S0.7910.91
257_S260_K0.7900.91
107_M110_A0.7890.91
39_V43_G0.7840.91
85_L89_L0.7840.91
232_Q236_K0.7820.91
255_Y258_F0.7820.91
161_R226_E0.7800.91
35_E38_S0.7790.91
160_L164_Q0.7790.91
141_L153_R0.7780.91
18_T37_A0.7760.91
195_P198_I0.7760.91
20_V30_R0.7750.91
66_A107_M0.7720.90
221_N225_S0.7670.90
135_K230_L0.7660.90
258_F261_R0.7660.90
40_D77_M0.7520.89
118_A122_S0.7510.89
105_V113_G0.7500.89
168_N214_I0.7490.89
42_V46_K0.7470.89
48_V87_P0.7460.89
154_E226_E0.7450.89
218_R221_N0.7440.89
20_V58_F0.7420.89
86_Y92_Y0.7410.88
194_N197_K0.7410.88
136_G145_I0.7360.88
8_Y24_D0.7350.88
191_N197_K0.7320.88
38_S41_K0.7320.88
47_S51_L0.7290.88
230_L234_V0.7280.88
231_V259_F0.7280.88
49_L218_R0.7270.87
65_I93_A0.7260.87
159_L172_L0.7220.87
155_F201_F0.7050.86
118_A249_M0.7040.86
141_L149_F0.7020.86
155_F208_A0.7010.86
73_D134_I0.7000.85
108_S244_Y0.7000.85
19_K31_Q0.6990.85
30_R54_I0.6970.85
254_V257_S0.6960.85
155_F216_A0.6940.85
233_M237_A0.6880.84
34_Y58_F0.6880.84
45_Y84_Q0.6840.84
206_L252_S0.6830.84
260_K264_E0.6830.84
8_Y23_H0.6810.84
229_T266_K0.6780.84
215_K218_R0.6770.84
104_V115_I0.6770.84
79_K82_K0.6720.83
160_L163_F0.6700.83
17_S117_I0.6690.83
116_T245_Y0.6640.82
106_L110_A0.6620.82
10_L68_S0.6580.82
52_S88_R0.6540.81
126_G234_V0.6530.81
133_I237_A0.6500.81
109_N246_F0.6490.81
255_Y260_K0.6480.81
209_I216_A0.6440.80
145_I153_R0.6430.80
261_R265_K0.6420.80
48_V88_R0.6420.80
13_A122_S0.6400.80
182_E187_F0.6370.80
159_L170_R0.6360.80
21_F28_I0.6340.79
221_N224_M0.6290.79
123_I246_F0.6280.79
118_A147_S0.6270.79
263_L266_K0.6260.78
64_R97_I0.6260.78
207_N210_R0.6230.78
12_D17_S0.6210.78
14_G120_T0.6170.77
114_C126_G0.6160.77
114_C235_C0.6140.77
161_R166_L0.6110.77
184_L198_I0.6110.77
103_H127_F0.6100.77
99_E104_V0.6090.77
44_P83_G0.6080.76
186_R189_Y0.6010.76
107_M115_I0.6000.76
220_L254_V0.5990.75
126_G237_A0.5990.75
148_G202_S0.5980.75
42_V47_S0.5910.74
49_L52_S0.5900.74
209_I224_M0.5890.74
256_V259_F0.5870.74
104_V233_M0.5860.74
39_V194_N0.5860.74
71_G143_G0.5830.73
166_L226_E0.5820.73
59_N63_D0.5790.73
158_E162_E0.5770.73
128_D133_I0.5760.73
45_Y192_S0.5750.72
103_H125_Y0.5730.72
142_V189_Y0.5720.72
221_N254_V0.5710.72
76_V80_E0.5710.72
70_A106_L0.5670.71
163_F182_E0.5660.71
68_S123_I0.5640.71
175_F200_Q0.5630.71
184_L187_F0.5620.71
109_N115_I0.5610.71
171_S174_Q0.5610.71
104_V165_G0.5600.70
125_Y132_R0.5600.70
209_I217_I0.5600.70
81_V84_Q0.5590.70
39_V152_G0.5580.70
126_G132_R0.5560.70
210_R254_V0.5520.69
250_Y255_Y0.5520.69
165_G170_R0.5520.69
55_V60_K0.5510.69
122_S227_F0.5490.69
80_E83_G0.5480.69
26_E29_V0.5460.69
202_S223_C0.5460.69
151_L155_F0.5460.69
135_K233_M0.5450.68
224_M227_F0.5450.68
243_V263_L0.5440.68
102_A117_I0.5440.68
136_G164_Q0.5430.68
62_F248_G0.5410.68
32_Y35_E0.5400.68
156_L161_R0.5400.68
63_D95_K0.5350.67
159_L176_S0.5350.67
10_L107_M0.5350.67
142_V156_L0.5340.67
202_S249_M0.5330.67
22_V60_K0.5330.67
85_L88_R0.5300.66
12_D16_T0.5290.66
46_K61_K0.5270.66
66_A97_I0.5250.66
39_V123_I0.5240.65
253_P256_V0.5220.65
231_V235_C0.5220.65
162_E169_D0.5210.65
75_E82_K0.5210.65
259_F262_E0.5210.65
37_A70_A0.5210.65
51_L54_I0.5200.65
63_D94_D0.5180.65
220_L224_M0.5170.64
245_Y250_Y0.5160.64
202_S220_L0.5160.64
196_A204_N0.5160.64
254_V263_L0.5140.64
16_T199_A0.5140.64
225_S229_T0.5130.64
155_F159_L0.5110.63
89_L93_A0.5100.63
95_K171_S0.5080.63
87_P177_T0.5070.63
27_K87_P0.5060.63
68_S136_G0.5030.62
21_F107_M0.5030.62
52_S55_V0.5030.62
204_N208_A0.5020.62
125_Y131_Q0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ch5A 2 0.986 100 0.495 Contact Map
2e2oA 2 0.9615 100 0.513 Contact Map
1zbsA 2 0.9336 100 0.525 Contact Map
1zxoA 4 0.9336 100 0.534 Contact Map
1zc6A 2 0.9301 100 0.54 Contact Map
2ap1A 2 0.9266 99.9 0.633 Contact Map
2yhwA 2 0.9126 99.9 0.645 Contact Map
4db3A 2 0.9021 99.9 0.647 Contact Map
3r8eA 2 0.9056 99.9 0.653 Contact Map
3vglA 3 0.9161 99.9 0.655 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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