GREMLIN Database
Q97ZG5 - Uncharacterized protein
UniProt: Q97ZG5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 251 (196)
Sequences: 952 (693)
Seq/√Len: 49.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_V138_I5.2031.00
161_R173_K4.2581.00
23_N67_K4.0451.00
161_R202_G3.6841.00
24_S70_I3.4051.00
152_T191_I3.3501.00
142_H155_I3.2601.00
69_L104_V3.2131.00
19_V22_A2.9731.00
68_K103_E2.6611.00
163_S171_S2.5871.00
27_L57_T2.4771.00
14_L63_V2.3991.00
12_E64_F2.3491.00
16_A60_V2.3191.00
68_K105_T2.3071.00
197_G200_Q2.2371.00
14_L60_V2.1881.00
70_I138_I2.1341.00
24_S68_K2.1171.00
22_A133_L2.1151.00
72_N138_I2.1101.00
7_G21_Q2.0411.00
53_F197_G2.0271.00
11_A17_L1.9780.99
107_V128_V1.9690.99
57_T196_I1.8560.99
71_V75_F1.8520.99
195_A200_Q1.8440.99
60_V196_I1.7940.99
158_E192_V1.7760.99
68_K133_L1.7070.98
34_Y200_Q1.6480.98
69_L102_V1.6350.98
32_I53_F1.6330.98
56_I196_I1.5940.98
161_R204_D1.5910.98
98_K102_V1.5780.97
104_V125_V1.5530.97
18_Y23_N1.5270.97
132_D151_T1.5270.97
38_M43_I1.5250.97
142_H158_E1.5020.96
94_L97_L1.4840.96
69_L205_I1.4810.96
178_L192_V1.4700.96
58_N96_Y1.4380.95
152_T179_S1.4130.95
61_L66_T1.4020.95
9_L19_V1.3410.93
19_V133_L1.3400.93
136_I152_T1.3340.93
70_I105_T1.3170.93
158_E161_R1.3150.93
93_I96_Y1.3050.92
152_T187_N1.2930.92
15_P56_I1.2860.92
17_L191_I1.2830.92
139_T153_Y1.2700.91
12_E15_P1.2650.91
72_N197_G1.2550.91
103_E129_D1.2450.91
6_K135_E1.2320.90
49_Q53_F1.2130.89
52_R198_I1.2080.89
25_V60_V1.2020.89
165_R171_S1.1970.89
18_Y64_F1.1970.89
10_I20_K1.1730.88
39_S44_Y1.1570.87
26_V70_I1.1530.87
36_E78_T1.1370.86
161_R195_A1.1310.86
9_L155_I1.1310.86
81_K199_Y1.1160.85
105_T128_V1.1110.85
179_S191_I1.0960.84
136_I191_I1.0630.82
78_T113_N1.0610.82
19_V138_I1.0500.81
40_R187_N1.0490.81
36_E49_Q1.0480.81
35_E199_Y1.0340.80
127_L130_E1.0330.80
136_I154_I1.0320.80
9_L26_V0.9880.77
79_F114_Y0.9860.77
60_V64_F0.9840.77
94_L102_V0.9740.76
111_H157_H0.9740.76
34_Y201_A0.9700.76
40_R176_C0.9620.75
34_Y38_M0.9610.75
9_L136_I0.9430.74
108_R129_D0.9360.73
31_H111_H0.9340.73
155_I158_E0.9290.73
36_E39_S0.9270.72
58_N62_S0.9220.72
34_Y76_K0.9210.72
7_G134_G0.9170.72
5_A8_I0.9110.71
197_G201_A0.9100.71
65_N135_E0.9090.71
196_I199_Y0.9050.71
61_L108_R0.9000.70
158_E173_K0.8960.70
67_K143_K0.8960.70
31_H157_H0.8890.69
35_E118_V0.8860.69
40_R171_S0.8830.69
141_G192_V0.8820.69
10_I18_Y0.8750.68
54_F195_A0.8710.68
9_L135_E0.8680.67
89_E92_E0.8660.67
107_V129_D0.8580.66
176_C201_A0.8400.65
133_L208_I0.8390.65
49_Q75_F0.8380.65
104_V141_G0.8380.65
28_S108_R0.8350.64
38_M77_H0.8330.64
33_G49_Q0.8300.64
92_E133_L0.8270.64
11_A175_Q0.8260.64
39_S200_Q0.8250.63
193_L200_Q0.8220.63
144_V164_I0.8200.63
177_F191_I0.8130.62
173_K204_D0.8080.62
5_A171_S0.8020.61
12_E16_A0.7930.60
21_Q67_K0.7930.60
132_D135_E0.7890.60
155_I190_V0.7880.60
74_D140_H0.7840.59
15_P197_G0.7830.59
5_A89_E0.7800.59
55_T62_S0.7780.59
88_E92_E0.7750.59
32_I197_G0.7720.58
46_P77_H0.7710.58
18_Y136_I0.7680.58
92_E96_Y0.7650.58
154_I193_L0.7630.57
61_L102_V0.7620.57
37_E77_H0.7550.57
95_K99_D0.7500.56
142_H173_K0.7500.56
164_I202_G0.7390.55
59_R63_V0.7360.55
158_E203_N0.7350.55
35_E38_M0.7310.54
62_S132_D0.7300.54
17_L67_K0.7300.54
61_L97_L0.7240.53
78_T203_N0.7210.53
93_I97_L0.7190.53
138_I154_I0.7090.52
50_K72_N0.7070.52
52_R56_I0.7070.52
44_Y199_Y0.7060.52
98_K104_V0.7050.52
33_G36_E0.7050.52
14_L177_F0.7040.51
32_I71_V0.7030.51
165_R204_D0.7000.51
49_Q78_T0.6990.51
5_A205_I0.6970.51
154_I191_I0.6950.50
98_K120_E0.6910.50
105_T131_L0.6870.50
39_S48_I0.6870.50
74_D111_H0.6860.50
33_G85_Q0.6840.49
111_H140_H0.6840.49
119_T122_F0.6800.49
16_A27_L0.6790.49
54_F201_A0.6780.49
158_E188_S0.6760.49
27_L146_E0.6760.49
34_Y174_L0.6730.48
62_S97_L0.6700.48
36_E108_R0.6690.48
5_A189_Q0.6650.47
90_L94_L0.6640.47
125_V174_L0.6640.47
24_S138_I0.6580.47
78_T106_I0.6570.47
27_L51_K0.6570.47
28_S193_L0.6570.47
74_D109_G0.6560.47
109_G140_H0.6530.46
34_Y197_G0.6520.46
95_K146_E0.6480.46
112_D157_H0.6470.46
28_S56_I0.6470.46
27_L53_F0.6420.45
33_G84_R0.6390.45
35_E141_G0.6380.45
22_A134_G0.6330.44
59_R147_P0.6310.44
108_R118_V0.6300.44
34_Y54_F0.6290.44
176_C200_Q0.6280.44
62_S67_K0.6270.44
13_D63_V0.6270.44
37_E122_F0.6270.44
103_E126_K0.6260.43
89_E164_I0.6250.43
75_F174_L0.6250.43
46_P103_E0.6240.43
31_H112_D0.6180.43
53_F141_G0.6160.42
36_E50_K0.6160.42
10_I64_F0.6160.42
33_G179_S0.6140.42
26_V137_L0.6130.42
28_S71_V0.6090.42
21_Q129_D0.6050.41
30_V203_N0.6040.41
97_L104_V0.6010.41
31_H74_D0.5990.41
31_H140_H0.5970.41
34_Y39_S0.5930.40
174_L201_A0.5930.40
67_K92_E0.5920.40
74_D157_H0.5920.40
7_G22_A0.5910.40
140_H157_H0.5890.40
136_I165_R0.5850.39
201_A213_M0.5840.39
69_L80_E0.5820.39
50_K155_I0.5790.39
92_E95_K0.5780.39
206_S212_Y0.5750.38
26_V72_N0.5710.38
132_D147_P0.5710.38
187_N192_V0.5700.38
53_F72_N0.5700.38
75_F153_Y0.5680.38
45_I203_N0.5670.38
22_A68_K0.5670.38
71_V104_V0.5670.38
75_F108_R0.5660.38
134_G143_K0.5640.37
130_E139_T0.5630.37
89_E207_L0.5630.37
55_T96_Y0.5620.37
97_L102_V0.5620.37
45_I83_T0.5610.37
89_E163_S0.5580.37
21_Q151_T0.5560.37
108_R114_Y0.5530.36
35_E49_Q0.5490.36
139_T195_A0.5440.36
167_K170_F0.5430.35
18_Y61_L0.5410.35
67_K193_L0.5400.35
175_Q195_A0.5400.35
85_Q96_Y0.5390.35
36_E90_L0.5370.35
25_V57_T0.5340.35
83_T86_E0.5330.34
57_T132_D0.5330.34
5_A10_I0.5320.34
74_D112_D0.5320.34
33_G90_L0.5300.34
112_D140_H0.5290.34
58_N93_I0.5290.34
108_R128_V0.5270.34
72_N155_I0.5230.34
132_D137_L0.5200.33
66_T119_T0.5200.33
7_G19_V0.5190.33
106_I127_L0.5180.33
63_V192_V0.5160.33
65_N189_Q0.5140.33
40_R82_L0.5120.33
73_G159_H0.5120.33
17_L98_K0.5110.32
137_L147_P0.5100.32
88_E98_K0.5100.32
135_E152_T0.5090.32
67_K95_K0.5080.32
80_E83_T0.5070.32
10_I55_T0.5050.32
27_L103_E0.5050.32
33_G39_S0.5040.32
97_L119_T0.5040.32
35_E50_K0.5040.32
28_S106_I0.5010.32
7_G11_A0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1xm7A 1 0.6454 99.4 0.801 Contact Map
1su1A 3 0.6813 99.3 0.815 Contact Map
4nzvA 1 0.8845 99.3 0.816 Contact Map
3thoB 2 0.8247 99.2 0.821 Contact Map
2a22A 1 0.7131 99.1 0.83 Contact Map
1z2wA 2 0.6693 99.1 0.834 Contact Map
2yvtA 1 0.6335 99 0.834 Contact Map
1ii7A 2 0.8645 99 0.835 Contact Map
1s3lA 1 0.5936 99 0.835 Contact Map
3av0A 1 0.8765 99 0.838 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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