GREMLIN Database
Q97ZG4 - Uncharacterized protein
UniProt: Q97ZG4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 226 (188)
Sequences: 421 (315)
Seq/√Len: 23.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
183_E187_K5.8171.00
102_K106_K4.9921.00
93_L142_I3.3811.00
64_L69_E3.1481.00
130_N138_I2.8410.99
105_S146_F2.8130.99
119_N123_I2.6370.99
38_Y41_D2.6260.99
70_I74_S2.4870.98
130_N215_E2.4530.98
99_E102_K2.3360.97
86_V100_F2.2880.97
102_K144_Y2.2360.97
90_F100_F2.2180.96
206_H211_D2.1980.96
40_E43_K2.1370.96
85_F152_D2.0210.94
87_A182_L2.0190.94
84_V104_A2.0160.94
89_T115_A2.0080.94
65_L69_E2.0040.94
61_A65_L1.9140.92
161_E190_L1.8320.90
103_E106_K1.8260.90
70_I73_N1.8030.89
44_Y49_G1.8010.89
180_K186_K1.7730.89
104_A123_I1.7730.89
130_N134_T1.7350.87
50_D55_L1.6900.86
85_F113_T1.6690.85
104_A108_G1.6350.84
49_G53_T1.6190.83
157_L188_R1.5800.82
137_E140_K1.5560.81
177_D193_Q1.5510.81
44_Y48_K1.4990.78
70_I75_D1.4800.77
38_Y45_Y1.4650.77
179_A212_I1.4590.76
58_V62_E1.4550.76
130_N142_I1.4410.75
219_R223_L1.4400.75
40_E44_Y1.4380.75
30_K35_A1.4240.75
32_V35_A1.4180.74
120_S128_P1.4160.74
115_A152_D1.4060.74
60_Y65_L1.3930.73
30_K34_L1.3920.73
38_Y44_Y1.3650.71
39_T42_A1.3550.71
41_D44_Y1.3440.70
53_T67_A1.3380.70
186_K191_S1.3180.69
171_G194_I1.2730.66
171_G175_K1.2640.65
117_D125_G1.2630.65
133_Q150_L1.2570.65
63_G67_A1.2530.65
95_P98_I1.2490.64
104_A110_V1.2400.64
94_H209_T1.2380.64
68_K164_N1.2350.63
184_E188_R1.2320.63
170_L182_L1.2310.63
31_V34_L1.2290.63
45_Y49_G1.2170.62
95_P138_I1.1540.58
33_E37_L1.1530.58
71_Y74_S1.1520.58
47_E53_T1.1490.58
93_L130_N1.1350.57
71_Y75_D1.1190.56
56_V68_K1.0900.54
157_L185_L1.0810.53
77_K214_N1.0740.53
42_A45_Y1.0720.52
33_E36_R1.0710.52
116_R152_D1.0690.52
212_I215_E1.0670.52
42_A46_L1.0650.52
142_I170_L1.0650.52
89_T120_S1.0610.52
196_R206_H1.0600.52
36_R58_V1.0560.51
157_L187_K1.0540.51
53_T57_D1.0110.48
61_A66_D0.9990.47
115_A127_K0.9920.47
94_H112_V0.9780.46
47_E50_D0.9610.45
33_E49_G0.9490.44
210_T220_Y0.9410.43
37_L40_E0.9390.43
107_Y192_P0.9370.43
37_L58_V0.9300.43
180_K191_S0.9290.43
57_D65_L0.9260.42
61_A67_A0.9210.42
104_A112_V0.9210.42
34_L51_Y0.9200.42
34_L38_Y0.9200.42
193_Q211_D0.9180.42
109_R164_N0.9080.41
134_T138_I0.8950.40
115_A132_E0.8930.40
112_V134_T0.8930.40
59_V65_L0.8890.40
42_A61_A0.8870.40
39_T46_L0.8800.39
84_V108_G0.8800.39
83_K132_E0.8780.39
53_T60_Y0.8700.39
172_P195_I0.8690.39
77_K127_K0.8670.38
54_A57_D0.8590.38
34_L41_D0.8560.38
87_A146_F0.8530.37
84_V118_S0.8510.37
89_T181_L0.8340.36
92_I142_I0.8320.36
45_Y53_T0.8310.36
154_E165_P0.8290.36
207_S223_L0.8200.35
131_D152_D0.8180.35
59_V69_E0.8170.35
46_L50_D0.8120.35
36_R40_E0.8120.35
33_E39_T0.8120.35
55_L66_D0.8110.35
121_E128_P0.8070.35
166_D223_L0.8070.35
217_K222_N0.8060.34
112_V136_L0.8060.34
112_V139_I0.8040.34
93_L138_I0.8030.34
56_V59_V0.7970.34
161_E176_V0.7960.34
145_V209_T0.7930.34
141_S208_S0.7920.34
106_K143_R0.7870.33
136_L150_L0.7850.33
128_P137_E0.7840.33
57_D68_K0.7820.33
32_V38_Y0.7800.33
103_E114_V0.7790.33
88_G91_D0.7760.33
153_Q182_L0.7740.32
109_R134_T0.7700.32
105_S174_Q0.7690.32
139_I150_L0.7600.32
109_R117_D0.7550.31
32_V67_A0.7550.31
64_L68_K0.7550.31
140_K150_L0.7500.31
124_K166_D0.7440.31
72_E75_D0.7370.30
153_Q159_S0.7360.30
153_Q168_I0.7350.30
157_L184_E0.7310.30
41_D53_T0.7280.30
58_V63_G0.7270.30
58_V66_D0.7240.30
149_I172_P0.7230.29
99_E213_I0.7190.29
66_D133_Q0.7170.29
109_R161_E0.7130.29
48_K54_A0.7100.29
50_D63_G0.7090.29
87_A113_T0.7060.28
149_I163_I0.7040.28
220_Y224_E0.7040.28
60_Y68_K0.6960.28
90_F127_K0.6940.28
40_E47_E0.6900.28
221_C225_Q0.6880.27
158_K162_R0.6870.27
102_K213_I0.6870.27
184_E187_K0.6860.27
51_Y54_A0.6860.27
115_A120_S0.6850.27
87_A170_L0.6850.27
48_K53_T0.6800.27
89_T98_I0.6790.27
141_S163_I0.6780.27
69_E162_R0.6780.27
104_A217_K0.6760.27
36_R39_T0.6750.27
222_N225_Q0.6730.27
61_A69_E0.6680.26
58_V61_A0.6670.26
34_L40_E0.6660.26
42_A54_A0.6650.26
90_F187_K0.6610.26
93_L139_I0.6590.26
47_E52_I0.6520.26
111_Y165_P0.6480.25
64_L67_A0.6450.25
48_K51_Y0.6430.25
63_G66_D0.6370.25
157_L161_E0.6330.25
55_L69_E0.6330.25
32_V39_T0.6310.24
138_I142_I0.6300.24
47_E51_Y0.6280.24
57_D64_L0.6270.24
105_S143_R0.6250.24
134_T215_E0.6240.24
123_I217_K0.6220.24
62_E66_D0.6190.24
113_T159_S0.6170.24
55_L62_E0.6160.24
55_L161_E0.6150.24
82_K108_G0.6140.24
165_P219_R0.6100.23
132_E136_L0.6100.23
32_V36_R0.6080.23
93_L101_L0.6060.23
50_D54_A0.6030.23
30_K40_E0.6010.23
138_I151_G0.6010.23
119_N188_R0.5990.23
100_F224_E0.5970.23
36_R43_K0.5940.23
40_E59_V0.5930.23
173_D176_V0.5920.22
45_Y55_L0.5920.22
178_E212_I0.5910.22
108_G219_R0.5900.22
50_D65_L0.5870.22
56_V61_A0.5840.22
33_E69_E0.5840.22
60_Y131_D0.5840.22
56_V60_Y0.5800.22
169_F175_K0.5790.22
127_K218_K0.5720.22
132_E138_I0.5720.22
34_L39_T0.5700.21
129_I211_D0.5700.21
52_I58_V0.5660.21
91_D113_T0.5640.21
47_E57_D0.5630.21
38_Y84_V0.5610.21
35_A42_A0.5610.21
45_Y54_A0.5600.21
88_G94_H0.5590.21
175_K197_L0.5590.21
83_K196_R0.5580.21
40_E49_G0.5570.21
159_S175_K0.5570.21
57_D67_A0.5560.21
103_E197_L0.5550.21
48_K52_I0.5470.20
100_F194_I0.5470.20
128_P141_S0.5450.20
37_L50_D0.5440.20
90_F214_N0.5390.20
60_Y143_R0.5380.20
117_D135_R0.5330.20
81_S148_A0.5330.20
88_G96_G0.5320.20
196_R208_S0.5320.20
80_V166_D0.5300.20
38_Y62_E0.5300.20
95_P144_Y0.5280.20
67_A71_Y0.5260.19
186_K223_L0.5260.19
127_K181_L0.5220.19
187_K190_L0.5190.19
43_K46_L0.5180.19
41_D49_G0.5170.19
65_L158_K0.5160.19
169_F219_R0.5160.19
60_Y69_E0.5150.19
112_V143_R0.5100.19
110_V206_H0.5090.19
58_V64_L0.5080.19
214_N218_K0.5040.19
147_D169_F0.5030.18
103_E163_I0.5010.18
214_N219_R0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3elbA 2 0.8009 100 0.526 Contact Map
4mvcA 2 0.7611 100 0.618 Contact Map
3hl4A 2 0.7434 99.9 0.647 Contact Map
3glvA 2 0.5354 99.8 0.717 Contact Map
2b7lA 2 0.5 99.8 0.73 Contact Map
1cozA 2 0.5487 99.8 0.735 Contact Map
3do8A 2 0.5487 99.6 0.78 Contact Map
1mrzA 2 0.6062 99.4 0.804 Contact Map
3op1A 4 0.6991 99.3 0.808 Contact Map
2x0kA 5 0.6903 99.2 0.818 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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