GREMLIN Database
Q97ZG2 - Uncharacterized protein
UniProt: Q97ZG2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 365 (307)
Sequences: 323 (159)
Seq/√Len: 9.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
227_E262_I5.7771.00
204_E220_Q4.7581.00
63_E66_R4.5120.99
162_L173_T4.0120.98
202_P206_K3.9190.98
203_N206_K3.7760.97
197_V226_L2.9640.90
162_L165_E2.9320.90
272_A289_P2.8660.88
203_N255_E2.7630.87
186_A224_K2.7030.85
115_I142_P2.6650.84
250_E255_E2.6460.84
111_V162_L2.5640.82
244_K293_E2.5580.82
139_A246_Y2.4870.80
175_L188_L2.4770.80
308_K329_K2.4570.79
33_G64_S2.4310.78
27_E39_K2.4240.78
217_N221_L2.3450.76
48_L131_V2.3360.75
47_A53_S2.3110.74
36_S110_I2.3070.74
158_K161_D2.1750.70
65_H138_D2.1620.69
197_V229_L2.0720.66
139_A298_A2.0550.65
142_P321_L2.0280.64
108_E112_E2.0130.63
139_A158_K1.9640.61
295_R312_E1.9060.59
74_A98_D1.8930.58
128_R131_V1.8830.58
78_W181_R1.8360.56
108_E165_E1.8180.55
296_E299_K1.8080.55
299_K303_Q1.7980.54
302_G321_L1.7410.52
83_H243_I1.7360.52
185_L238_I1.7150.51
104_Y158_K1.7090.50
226_L238_I1.6740.49
165_E272_A1.6710.49
159_L184_I1.6580.48
240_F260_M1.6400.47
275_H287_A1.6280.47
183_D186_A1.6110.46
96_W175_L1.6030.46
125_Y317_R1.5990.46
205_I209_M1.5970.46
199_L238_I1.5960.46
115_I169_R1.5450.43
109_Y113_R1.5300.43
206_K250_E1.5220.42
48_L272_A1.5190.42
200_Q211_N1.5060.42
254_K304_Y1.5000.41
115_I165_E1.4950.41
106_D216_A1.4470.39
79_F200_Q1.4400.39
225_T276_V1.4350.39
255_E268_I1.4320.39
16_T248_M1.4300.39
78_W180_V1.4260.38
110_I173_T1.4190.38
258_K262_I1.4120.38
167_H197_V1.4080.38
115_I119_R1.4010.37
136_V298_A1.3940.37
110_I162_L1.3900.37
185_L199_L1.3720.36
45_H322_S1.3670.36
178_S235_P1.3560.35
191_E274_M1.3520.35
36_S319_V1.3520.35
206_K253_A1.3450.35
136_V302_G1.3430.35
160_G184_I1.3390.35
22_K122_V1.3380.35
169_R177_T1.3350.35
185_L232_F1.3300.34
270_I319_V1.3290.34
111_V116_E1.3270.34
97_D124_G1.3240.34
69_Q180_V1.3240.34
284_S287_A1.3170.34
72_P153_P1.3140.34
206_K256_F1.3120.34
37_A272_A1.3100.34
31_I58_K1.3090.34
226_L260_M1.3050.33
270_I298_A1.2980.33
199_L225_T1.2920.33
191_E232_F1.2840.33
40_K155_L1.2840.33
223_M262_I1.2790.32
164_K189_E1.2790.32
231_S306_G1.2560.32
46_S50_A1.2540.32
179_G207_H1.2480.31
225_T314_V1.2360.31
108_E163_I1.2270.31
68_V166_Y1.2200.30
198_S274_M1.2080.30
57_G68_V1.1920.29
36_S105_D1.1850.29
46_S313_H1.1850.29
37_A71_T1.1840.29
166_Y240_F1.1840.29
158_K228_I1.1820.29
310_L322_S1.1780.29
240_F267_Y1.1680.28
44_T207_H1.1660.28
27_E37_A1.1550.28
126_L136_V1.1510.28
68_V171_M1.1400.27
240_F274_M1.1320.27
199_L222_V1.1280.27
158_K314_V1.1270.27
68_V144_H1.1230.27
200_Q232_F1.1190.27
114_S207_H1.1160.27
266_T291_H1.1090.26
226_L283_L1.1000.26
280_T317_R1.0890.26
197_V225_T1.0850.26
171_M322_S1.0840.26
133_I137_K1.0820.25
283_L321_L1.0810.25
288_M317_R1.0790.25
82_V207_H1.0780.25
83_H87_L1.0600.25
125_Y139_A1.0510.24
42_H46_S1.0460.24
53_S263_A1.0450.24
91_D122_V1.0440.24
302_G306_G1.0400.24
187_S298_A1.0390.24
80_R159_L1.0310.24
37_A238_I1.0300.24
31_I36_S1.0300.24
300_I314_V1.0300.24
124_G179_G1.0290.24
79_F207_H1.0270.24
97_D162_L1.0220.23
207_H218_S1.0140.23
119_R142_P1.0140.23
279_S317_R1.0130.23
69_Q79_F1.0080.23
44_T128_R1.0070.23
65_H142_P1.0030.23
113_R116_E1.0030.23
113_R122_V0.9980.23
118_H172_T0.9880.22
132_S293_E0.9830.22
253_A257_A0.9820.22
45_H287_A0.9810.22
40_K51_N0.9750.22
228_I303_Q0.9680.22
185_L299_K0.9660.22
106_D158_K0.9660.22
209_M323_K0.9580.22
170_G245_G0.9510.21
223_M259_L0.9440.21
66_R292_K0.9430.21
40_K121_A0.9410.21
323_K326_K0.9320.21
259_L293_E0.9290.21
295_R319_V0.9270.21
136_V286_D0.9240.21
16_T185_L0.9200.20
155_L298_A0.9190.20
206_K249_S0.9150.20
122_V326_K0.9140.20
298_A319_V0.9130.20
173_T220_Q0.9130.20
165_E323_K0.9110.20
309_I319_V0.9100.20
83_H322_S0.9080.20
303_Q330_I0.9070.20
89_P274_M0.9060.20
33_G265_P0.9040.20
37_A248_M0.8970.20
202_P205_I0.8960.20
145_V166_Y0.8940.20
134_Q141_K0.8930.20
125_Y314_V0.8920.20
131_V299_K0.8880.20
211_N237_V0.8860.20
27_E272_A0.8840.19
69_Q318_I0.8840.19
31_I112_E0.8800.19
188_L213_P0.8730.19
227_E268_I0.8730.19
168_K306_G0.8710.19
309_I321_L0.8690.19
163_I205_I0.8690.19
75_A167_H0.8680.19
226_L279_S0.8670.19
119_R141_K0.8660.19
74_A307_Y0.8660.19
111_V165_E0.8660.19
268_I321_L0.8640.19
223_M245_G0.8610.19
161_D230_P0.8610.19
87_L91_D0.8560.19
230_P296_E0.8550.19
259_L263_A0.8520.19
223_M295_R0.8410.18
110_I331_G0.8390.18
243_I256_F0.8390.18
203_N245_G0.8360.18
243_I309_I0.8330.18
185_L191_E0.8320.18
210_I248_M0.8320.18
276_V294_I0.8270.18
78_W177_T0.8270.18
255_E330_I0.8190.18
71_T98_D0.8160.18
79_F172_T0.8160.18
253_A301_L0.8140.18
111_V209_M0.8140.18
139_A161_D0.8090.17
261_E295_R0.8080.17
53_S188_L0.8070.17
119_R330_I0.8060.17
299_K326_K0.8060.17
253_A268_I0.8030.17
112_E255_E0.8010.17
207_H211_N0.8000.17
164_K299_K0.7970.17
28_K225_T0.7950.17
305_T319_V0.7950.17
20_I27_E0.7940.17
279_S283_L0.7930.17
124_G282_R0.7870.17
211_N315_P0.7870.17
209_M309_I0.7840.17
291_H294_I0.7830.17
32_I113_R0.7820.17
32_I117_E0.7790.17
107_P331_G0.7780.17
105_D114_S0.7770.17
117_E122_V0.7740.17
66_R141_K0.7710.17
161_D255_E0.7680.16
120_K304_Y0.7630.16
28_K289_P0.7610.16
164_K204_E0.7610.16
290_K293_E0.7600.16
165_E319_V0.7580.16
122_V143_A0.7530.16
249_S270_I0.7490.16
39_K91_D0.7480.16
178_S200_Q0.7470.16
59_F294_I0.7470.16
50_A68_V0.7440.16
133_I161_D0.7420.16
259_L320_L0.7420.16
138_D203_N0.7410.16
179_G225_T0.7380.16
206_K218_S0.7360.16
37_A309_I0.7350.16
275_H285_R0.7350.16
182_P237_V0.7330.16
121_A142_P0.7280.16
60_Y241_T0.7270.16
116_E175_L0.7250.15
273_Y282_R0.7240.15
91_D118_H0.7220.15
105_D115_I0.7210.15
111_V171_M0.7180.15
197_V236_T0.7160.15
204_E227_E0.7140.15
280_T318_I0.7130.15
183_D275_H0.7120.15
49_V71_T0.7120.15
71_T74_A0.7090.15
209_M286_D0.7070.15
287_A293_E0.7060.15
124_G273_Y0.7050.15
142_P245_G0.7040.15
223_M293_E0.7030.15
107_P110_I0.7010.15
137_K141_K0.6990.15
235_P267_Y0.6980.15
70_M114_S0.6970.15
163_I173_T0.6910.15
172_T238_I0.6900.15
44_T195_L0.6900.15
33_G244_K0.6890.15
189_E261_E0.6880.15
120_K137_K0.6850.15
128_R218_S0.6830.15
38_Y301_L0.6820.15
289_P297_F0.6820.15
198_S270_I0.6810.14
31_I319_V0.6770.14
143_A268_I0.6760.14
267_Y322_S0.6730.14
257_A260_M0.6700.14
150_T211_N0.6690.14
159_L309_I0.6690.14
296_E300_I0.6660.14
130_D203_N0.6660.14
32_I114_S0.6640.14
227_E255_E0.6630.14
116_E120_K0.6620.14
192_P328_I0.6610.14
240_F270_I0.6610.14
209_M216_A0.6600.14
108_E185_L0.6590.14
36_S144_H0.6580.14
202_P238_I0.6580.14
91_D150_T0.6540.14
45_H267_Y0.6530.14
17_V125_Y0.6530.14
235_P266_T0.6510.14
26_K36_S0.6510.14
111_V258_K0.6500.14
310_L318_I0.6450.14
80_R294_I0.6440.14
188_L301_L0.6430.14
37_A298_A0.6410.14
142_P170_G0.6410.14
184_I225_T0.6410.14
19_E22_K0.6390.14
185_L228_I0.6370.14
28_K272_A0.6340.13
115_I305_T0.6330.13
106_D175_L0.6310.13
230_P233_S0.6310.13
230_P264_M0.6300.13
66_R172_T0.6300.13
202_P256_F0.6290.13
270_I293_E0.6290.13
58_K274_M0.6280.13
125_Y170_G0.6250.13
117_E224_K0.6230.13
306_G314_V0.6220.13
49_V315_P0.6210.13
205_I275_H0.6200.13
163_I248_M0.6200.13
92_V98_D0.6180.13
159_L273_Y0.6140.13
265_P306_G0.6130.13
266_T323_K0.6120.13
158_K246_Y0.6110.13
228_I231_S0.6080.13
126_L141_K0.6040.13
111_V173_T0.6040.13
253_A300_I0.6040.13
303_Q319_V0.6020.13
104_Y228_I0.6010.13
131_V267_Y0.6000.13
25_Q136_V0.5990.13
273_Y288_M0.5990.13
193_T267_Y0.5990.13
73_T160_G0.5980.13
141_K204_E0.5960.13
50_A57_G0.5960.13
214_V243_I0.5950.13
154_T159_L0.5950.13
38_Y126_L0.5920.13
16_T31_I0.5900.13
15_D18_S0.5900.13
117_E125_Y0.5890.13
233_S250_E0.5890.13
66_R142_P0.5880.13
48_L292_K0.5870.13
314_V319_V0.5870.13
139_A223_M0.5870.13
326_K331_G0.5860.13
50_A217_N0.5850.13
92_V294_I0.5850.13
127_G169_R0.5840.13
178_S196_F0.5830.12
119_R261_E0.5820.12
33_G105_D0.5820.12
80_R200_Q0.5800.12
60_Y65_H0.5800.12
228_I243_I0.5790.12
53_S57_G0.5750.12
40_K128_R0.5750.12
270_I294_I0.5710.12
254_K257_A0.5700.12
273_Y294_I0.5700.12
47_A181_R0.5680.12
79_F211_N0.5680.12
52_R80_R0.5660.12
103_A172_T0.5650.12
89_P159_L0.5650.12
131_V306_G0.5640.12
38_Y196_F0.5630.12
154_T285_R0.5600.12
248_M260_M0.5590.12
161_D227_E0.5580.12
163_I175_L0.5550.12
58_K313_H0.5550.12
45_H203_N0.5510.12
42_H225_T0.5500.12
147_I159_L0.5500.12
254_K262_I0.5490.12
296_E302_G0.5480.12
205_I216_A0.5470.12
248_M272_A0.5420.12
45_H259_L0.5420.12
141_K296_E0.5400.12
48_L145_V0.5400.12
52_R157_E0.5400.12
279_S282_R0.5390.12
131_V307_Y0.5380.12
114_S166_Y0.5380.12
121_A127_G0.5370.12
80_R90_E0.5360.12
228_I246_Y0.5360.12
233_S267_Y0.5350.12
65_H115_I0.5340.12
36_S259_L0.5330.12
144_H307_Y0.5320.12
38_Y109_Y0.5310.12
165_E173_T0.5310.12
173_T258_K0.5300.12
222_V279_S0.5290.11
70_M245_G0.5260.11
32_I185_L0.5260.11
106_D244_K0.5250.11
257_A299_K0.5240.11
90_E207_H0.5240.11
109_Y303_Q0.5230.11
163_I224_K0.5220.11
244_K308_K0.5220.11
42_H50_A0.5220.11
27_E207_H0.5210.11
107_P288_M0.5200.11
255_E288_M0.5190.11
298_A321_L0.5190.11
137_K326_K0.5180.11
228_I232_F0.5170.11
168_K302_G0.5170.11
266_T294_I0.5170.11
282_R298_A0.5170.11
31_I39_K0.5130.11
142_P317_R0.5120.11
52_R315_P0.5110.11
224_K227_E0.5090.11
42_H49_V0.5090.11
259_L262_I0.5080.11
115_I216_A0.5060.11
34_T220_Q0.5040.11
34_T236_T0.5040.11
135_K138_D0.5040.11
172_T181_R0.5040.11
132_S202_P0.5030.11
44_T87_L0.5030.11
75_A200_Q0.5020.11
242_M248_M0.5010.11
168_K231_S0.5010.11
150_T200_Q0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yx0A 1 0.8685 100 0.643 Contact Map
2z2uA 1 0.7616 100 0.659 Contact Map
3c8fA 1 0.6384 99.8 0.883 Contact Map
3rfaA 1 0.8137 99.8 0.891 Contact Map
3canA 2 0.4247 99.7 0.899 Contact Map
1tv8A 2 0.7534 99.6 0.908 Contact Map
2qgqA 1 0.6438 99.4 0.917 Contact Map
4k36A 1 0.6712 99.4 0.918 Contact Map
4rtbA 2 0.8795 99.3 0.92 Contact Map
4wcxA 1 0.874 99.2 0.925 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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