Q97ZG2 - SULSO - GREMLIN Contacts

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Q97ZG2 - Uncharacterized protein

UniProt:	Q97ZG2	Sequences: MCDRMYNMQSNLRIDTVSEIFKELQKEKYHIIGTHSAYKKCHWTHSALVANRSCYKGKFYGIESHRCVQMTPTAAWCWFRCVHCWRLEPEDVGLEWDDTKMPAYDDPEYIVERSIEEHRKAVSGYLGRNDVSIQKVKDAMKPAHVAISLTGEPTLYEKLGDLIKEYHKRGMTTFLVTSGVRPDILASLEEEPTQLFVSLQAPNEIKHKMINRPVVANSWQLVMKTLEILPSFSSPTVIRFTMIKGYNMSEQDAKEFAKLMEIAMPTYIEIKAYMHVGPSTYRLSRDAMPKHKEIREFAKILGQYTGYKILSEHVPSRIVLLSKLDKPIKIGNAWNEKWNWSTIDMEDDMSGEYKEAEQGCTEGST	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	365 (307)
Sequences:	323 (159)
Seq/√Len:	9.1

HALSA - Q9HNF3
SULSO - Q97ZG2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
227_E	262_I	5.777	1.00
204_E	220_Q	4.758	1.00
63_E	66_R	4.512	0.99
162_L	173_T	4.012	0.98
202_P	206_K	3.919	0.98
203_N	206_K	3.776	0.97
197_V	226_L	2.964	0.90
162_L	165_E	2.932	0.90
272_A	289_P	2.866	0.88
203_N	255_E	2.763	0.87
186_A	224_K	2.703	0.85
115_I	142_P	2.665	0.84
250_E	255_E	2.646	0.84
111_V	162_L	2.564	0.82
244_K	293_E	2.558	0.82
139_A	246_Y	2.487	0.80
175_L	188_L	2.477	0.80
308_K	329_K	2.457	0.79
33_G	64_S	2.431	0.78
27_E	39_K	2.424	0.78
217_N	221_L	2.345	0.76
48_L	131_V	2.336	0.75
47_A	53_S	2.311	0.74
36_S	110_I	2.307	0.74
158_K	161_D	2.175	0.70
65_H	138_D	2.162	0.69
197_V	229_L	2.072	0.66
139_A	298_A	2.055	0.65
142_P	321_L	2.028	0.64
108_E	112_E	2.013	0.63
139_A	158_K	1.964	0.61
295_R	312_E	1.906	0.59
74_A	98_D	1.893	0.58
128_R	131_V	1.883	0.58
78_W	181_R	1.836	0.56
108_E	165_E	1.818	0.55
296_E	299_K	1.808	0.55
299_K	303_Q	1.798	0.54
302_G	321_L	1.741	0.52
83_H	243_I	1.736	0.52
185_L	238_I	1.715	0.51
104_Y	158_K	1.709	0.50
226_L	238_I	1.674	0.49
165_E	272_A	1.671	0.49
159_L	184_I	1.658	0.48
240_F	260_M	1.640	0.47
275_H	287_A	1.628	0.47
183_D	186_A	1.611	0.46
96_W	175_L	1.603	0.46
125_Y	317_R	1.599	0.46
205_I	209_M	1.597	0.46
199_L	238_I	1.596	0.46
115_I	169_R	1.545	0.43
109_Y	113_R	1.530	0.43
206_K	250_E	1.522	0.42
48_L	272_A	1.519	0.42
200_Q	211_N	1.506	0.42
254_K	304_Y	1.500	0.41
115_I	165_E	1.495	0.41
106_D	216_A	1.447	0.39
79_F	200_Q	1.440	0.39
225_T	276_V	1.435	0.39
255_E	268_I	1.432	0.39
16_T	248_M	1.430	0.39
78_W	180_V	1.426	0.38
110_I	173_T	1.419	0.38
258_K	262_I	1.412	0.38
167_H	197_V	1.408	0.38
115_I	119_R	1.401	0.37
136_V	298_A	1.394	0.37
110_I	162_L	1.390	0.37
185_L	199_L	1.372	0.36
45_H	322_S	1.367	0.36
178_S	235_P	1.356	0.35
191_E	274_M	1.352	0.35
36_S	319_V	1.352	0.35
206_K	253_A	1.345	0.35
136_V	302_G	1.343	0.35
160_G	184_I	1.339	0.35
22_K	122_V	1.338	0.35
169_R	177_T	1.335	0.35
185_L	232_F	1.330	0.34
270_I	319_V	1.329	0.34
111_V	116_E	1.327	0.34
97_D	124_G	1.324	0.34
69_Q	180_V	1.324	0.34
284_S	287_A	1.317	0.34
72_P	153_P	1.314	0.34
206_K	256_F	1.312	0.34
37_A	272_A	1.310	0.34
31_I	58_K	1.309	0.34
226_L	260_M	1.305	0.33
270_I	298_A	1.298	0.33
199_L	225_T	1.292	0.33
191_E	232_F	1.284	0.33
40_K	155_L	1.284	0.33
223_M	262_I	1.279	0.32
164_K	189_E	1.279	0.32
231_S	306_G	1.256	0.32
46_S	50_A	1.254	0.32
179_G	207_H	1.248	0.31
225_T	314_V	1.236	0.31
108_E	163_I	1.227	0.31
68_V	166_Y	1.220	0.30
198_S	274_M	1.208	0.30
57_G	68_V	1.192	0.29
36_S	105_D	1.185	0.29
46_S	313_H	1.185	0.29
37_A	71_T	1.184	0.29
166_Y	240_F	1.184	0.29
158_K	228_I	1.182	0.29
310_L	322_S	1.178	0.29
240_F	267_Y	1.168	0.28
44_T	207_H	1.166	0.28
27_E	37_A	1.155	0.28
126_L	136_V	1.151	0.28
68_V	171_M	1.140	0.27
240_F	274_M	1.132	0.27
199_L	222_V	1.128	0.27
158_K	314_V	1.127	0.27
68_V	144_H	1.123	0.27
200_Q	232_F	1.119	0.27
114_S	207_H	1.116	0.27
266_T	291_H	1.109	0.26
226_L	283_L	1.100	0.26
280_T	317_R	1.089	0.26
197_V	225_T	1.085	0.26
171_M	322_S	1.084	0.26
133_I	137_K	1.082	0.25
283_L	321_L	1.081	0.25
288_M	317_R	1.079	0.25
82_V	207_H	1.078	0.25
83_H	87_L	1.060	0.25
125_Y	139_A	1.051	0.24
42_H	46_S	1.046	0.24
53_S	263_A	1.045	0.24
91_D	122_V	1.044	0.24
302_G	306_G	1.040	0.24
187_S	298_A	1.039	0.24
80_R	159_L	1.031	0.24
37_A	238_I	1.030	0.24
31_I	36_S	1.030	0.24
300_I	314_V	1.030	0.24
124_G	179_G	1.029	0.24
79_F	207_H	1.027	0.24
97_D	162_L	1.022	0.23
207_H	218_S	1.014	0.23
119_R	142_P	1.014	0.23
279_S	317_R	1.013	0.23
69_Q	79_F	1.008	0.23
44_T	128_R	1.007	0.23
65_H	142_P	1.003	0.23
113_R	116_E	1.003	0.23
113_R	122_V	0.998	0.23
118_H	172_T	0.988	0.22
132_S	293_E	0.983	0.22
253_A	257_A	0.982	0.22
45_H	287_A	0.981	0.22
40_K	51_N	0.975	0.22
228_I	303_Q	0.968	0.22
185_L	299_K	0.966	0.22
106_D	158_K	0.966	0.22
209_M	323_K	0.958	0.22
170_G	245_G	0.951	0.21
223_M	259_L	0.944	0.21
66_R	292_K	0.943	0.21
40_K	121_A	0.941	0.21
323_K	326_K	0.932	0.21
259_L	293_E	0.929	0.21
295_R	319_V	0.927	0.21
136_V	286_D	0.924	0.21
16_T	185_L	0.920	0.20
155_L	298_A	0.919	0.20
206_K	249_S	0.915	0.20
122_V	326_K	0.914	0.20
298_A	319_V	0.913	0.20
173_T	220_Q	0.913	0.20
165_E	323_K	0.911	0.20
309_I	319_V	0.910	0.20
83_H	322_S	0.908	0.20
303_Q	330_I	0.907	0.20
89_P	274_M	0.906	0.20
33_G	265_P	0.904	0.20
37_A	248_M	0.897	0.20
202_P	205_I	0.896	0.20
145_V	166_Y	0.894	0.20
134_Q	141_K	0.893	0.20
125_Y	314_V	0.892	0.20
131_V	299_K	0.888	0.20
211_N	237_V	0.886	0.20
27_E	272_A	0.884	0.19
69_Q	318_I	0.884	0.19
31_I	112_E	0.880	0.19
188_L	213_P	0.873	0.19
227_E	268_I	0.873	0.19
168_K	306_G	0.871	0.19
309_I	321_L	0.869	0.19
163_I	205_I	0.869	0.19
75_A	167_H	0.868	0.19
226_L	279_S	0.867	0.19
119_R	141_K	0.866	0.19
74_A	307_Y	0.866	0.19
111_V	165_E	0.866	0.19
268_I	321_L	0.864	0.19
223_M	245_G	0.861	0.19
161_D	230_P	0.861	0.19
87_L	91_D	0.856	0.19
230_P	296_E	0.855	0.19
259_L	263_A	0.852	0.19
223_M	295_R	0.841	0.18
110_I	331_G	0.839	0.18
243_I	256_F	0.839	0.18
203_N	245_G	0.836	0.18
243_I	309_I	0.833	0.18
185_L	191_E	0.832	0.18
210_I	248_M	0.832	0.18
276_V	294_I	0.827	0.18
78_W	177_T	0.827	0.18
255_E	330_I	0.819	0.18
71_T	98_D	0.816	0.18
79_F	172_T	0.816	0.18
253_A	301_L	0.814	0.18
111_V	209_M	0.814	0.18
139_A	161_D	0.809	0.17
261_E	295_R	0.808	0.17
53_S	188_L	0.807	0.17
119_R	330_I	0.806	0.17
299_K	326_K	0.806	0.17
253_A	268_I	0.803	0.17
112_E	255_E	0.801	0.17
207_H	211_N	0.800	0.17
164_K	299_K	0.797	0.17
28_K	225_T	0.795	0.17
305_T	319_V	0.795	0.17
20_I	27_E	0.794	0.17
279_S	283_L	0.793	0.17
124_G	282_R	0.787	0.17
211_N	315_P	0.787	0.17
209_M	309_I	0.784	0.17
291_H	294_I	0.783	0.17
32_I	113_R	0.782	0.17
32_I	117_E	0.779	0.17
107_P	331_G	0.778	0.17
105_D	114_S	0.777	0.17
117_E	122_V	0.774	0.17
66_R	141_K	0.771	0.17
161_D	255_E	0.768	0.16
120_K	304_Y	0.763	0.16
28_K	289_P	0.761	0.16
164_K	204_E	0.761	0.16
290_K	293_E	0.760	0.16
165_E	319_V	0.758	0.16
122_V	143_A	0.753	0.16
249_S	270_I	0.749	0.16
39_K	91_D	0.748	0.16
178_S	200_Q	0.747	0.16
59_F	294_I	0.747	0.16
50_A	68_V	0.744	0.16
133_I	161_D	0.742	0.16
259_L	320_L	0.742	0.16
138_D	203_N	0.741	0.16
179_G	225_T	0.738	0.16
206_K	218_S	0.736	0.16
37_A	309_I	0.735	0.16
275_H	285_R	0.735	0.16
182_P	237_V	0.733	0.16
121_A	142_P	0.728	0.16
60_Y	241_T	0.727	0.16
116_E	175_L	0.725	0.15
273_Y	282_R	0.724	0.15
91_D	118_H	0.722	0.15
105_D	115_I	0.721	0.15
111_V	171_M	0.718	0.15
197_V	236_T	0.716	0.15
204_E	227_E	0.714	0.15
280_T	318_I	0.713	0.15
183_D	275_H	0.712	0.15
49_V	71_T	0.712	0.15
71_T	74_A	0.709	0.15
209_M	286_D	0.707	0.15
287_A	293_E	0.706	0.15
124_G	273_Y	0.705	0.15
142_P	245_G	0.704	0.15
223_M	293_E	0.703	0.15
107_P	110_I	0.701	0.15
137_K	141_K	0.699	0.15
235_P	267_Y	0.698	0.15
70_M	114_S	0.697	0.15
163_I	173_T	0.691	0.15
172_T	238_I	0.690	0.15
44_T	195_L	0.690	0.15
33_G	244_K	0.689	0.15
189_E	261_E	0.688	0.15
120_K	137_K	0.685	0.15
128_R	218_S	0.683	0.15
38_Y	301_L	0.682	0.15
289_P	297_F	0.682	0.15
198_S	270_I	0.681	0.14
31_I	319_V	0.677	0.14
143_A	268_I	0.676	0.14
267_Y	322_S	0.673	0.14
257_A	260_M	0.670	0.14
150_T	211_N	0.669	0.14
159_L	309_I	0.669	0.14
296_E	300_I	0.666	0.14
130_D	203_N	0.666	0.14
32_I	114_S	0.664	0.14
227_E	255_E	0.663	0.14
116_E	120_K	0.662	0.14
192_P	328_I	0.661	0.14
240_F	270_I	0.661	0.14
209_M	216_A	0.660	0.14
108_E	185_L	0.659	0.14
36_S	144_H	0.658	0.14
202_P	238_I	0.658	0.14
91_D	150_T	0.654	0.14
45_H	267_Y	0.653	0.14
17_V	125_Y	0.653	0.14
235_P	266_T	0.651	0.14
26_K	36_S	0.651	0.14
111_V	258_K	0.650	0.14
310_L	318_I	0.645	0.14
80_R	294_I	0.644	0.14
188_L	301_L	0.643	0.14
37_A	298_A	0.641	0.14
142_P	170_G	0.641	0.14
184_I	225_T	0.641	0.14
19_E	22_K	0.639	0.14
185_L	228_I	0.637	0.14
28_K	272_A	0.634	0.13
115_I	305_T	0.633	0.13
106_D	175_L	0.631	0.13
230_P	233_S	0.631	0.13
230_P	264_M	0.630	0.13
66_R	172_T	0.630	0.13
202_P	256_F	0.629	0.13
270_I	293_E	0.629	0.13
58_K	274_M	0.628	0.13
125_Y	170_G	0.625	0.13
117_E	224_K	0.623	0.13
306_G	314_V	0.622	0.13
49_V	315_P	0.621	0.13
205_I	275_H	0.620	0.13
163_I	248_M	0.620	0.13
92_V	98_D	0.618	0.13
159_L	273_Y	0.614	0.13
265_P	306_G	0.613	0.13
266_T	323_K	0.612	0.13
158_K	246_Y	0.611	0.13
228_I	231_S	0.608	0.13
126_L	141_K	0.604	0.13
111_V	173_T	0.604	0.13
253_A	300_I	0.604	0.13
303_Q	319_V	0.602	0.13
104_Y	228_I	0.601	0.13
131_V	267_Y	0.600	0.13
25_Q	136_V	0.599	0.13
273_Y	288_M	0.599	0.13
193_T	267_Y	0.599	0.13
73_T	160_G	0.598	0.13
141_K	204_E	0.596	0.13
50_A	57_G	0.596	0.13
214_V	243_I	0.595	0.13
154_T	159_L	0.595	0.13
38_Y	126_L	0.592	0.13
16_T	31_I	0.590	0.13
15_D	18_S	0.590	0.13
117_E	125_Y	0.589	0.13
233_S	250_E	0.589	0.13
66_R	142_P	0.588	0.13
48_L	292_K	0.587	0.13
314_V	319_V	0.587	0.13
139_A	223_M	0.587	0.13
326_K	331_G	0.586	0.13
50_A	217_N	0.585	0.13
92_V	294_I	0.585	0.13
127_G	169_R	0.584	0.13
178_S	196_F	0.583	0.12
119_R	261_E	0.582	0.12
33_G	105_D	0.582	0.12
80_R	200_Q	0.580	0.12
60_Y	65_H	0.580	0.12
228_I	243_I	0.579	0.12
53_S	57_G	0.575	0.12
40_K	128_R	0.575	0.12
270_I	294_I	0.571	0.12
254_K	257_A	0.570	0.12
273_Y	294_I	0.570	0.12
47_A	181_R	0.568	0.12
79_F	211_N	0.568	0.12
52_R	80_R	0.566	0.12
103_A	172_T	0.565	0.12
89_P	159_L	0.565	0.12
131_V	306_G	0.564	0.12
38_Y	196_F	0.563	0.12
154_T	285_R	0.560	0.12
248_M	260_M	0.559	0.12
161_D	227_E	0.558	0.12
163_I	175_L	0.555	0.12
58_K	313_H	0.555	0.12
45_H	203_N	0.551	0.12
42_H	225_T	0.550	0.12
147_I	159_L	0.550	0.12
254_K	262_I	0.549	0.12
296_E	302_G	0.548	0.12
205_I	216_A	0.547	0.12
248_M	272_A	0.542	0.12
45_H	259_L	0.542	0.12
141_K	296_E	0.540	0.12
48_L	145_V	0.540	0.12
52_R	157_E	0.540	0.12
279_S	282_R	0.539	0.12
131_V	307_Y	0.538	0.12
114_S	166_Y	0.538	0.12
121_A	127_G	0.537	0.12
80_R	90_E	0.536	0.12
228_I	246_Y	0.536	0.12
233_S	267_Y	0.535	0.12
65_H	115_I	0.534	0.12
36_S	259_L	0.533	0.12
144_H	307_Y	0.532	0.12
38_Y	109_Y	0.531	0.12
165_E	173_T	0.531	0.12
173_T	258_K	0.530	0.12
222_V	279_S	0.529	0.11
70_M	245_G	0.526	0.11
32_I	185_L	0.526	0.11
106_D	244_K	0.525	0.11
257_A	299_K	0.524	0.11
90_E	207_H	0.524	0.11
109_Y	303_Q	0.523	0.11
163_I	224_K	0.522	0.11
244_K	308_K	0.522	0.11
42_H	50_A	0.522	0.11
27_E	207_H	0.521	0.11
107_P	288_M	0.520	0.11
255_E	288_M	0.519	0.11
298_A	321_L	0.519	0.11
137_K	326_K	0.518	0.11
228_I	232_F	0.517	0.11
168_K	302_G	0.517	0.11
266_T	294_I	0.517	0.11
282_R	298_A	0.517	0.11
31_I	39_K	0.513	0.11
142_P	317_R	0.512	0.11
52_R	315_P	0.511	0.11
224_K	227_E	0.509	0.11
42_H	49_V	0.509	0.11
259_L	262_I	0.508	0.11
115_I	216_A	0.506	0.11
34_T	220_Q	0.504	0.11
34_T	236_T	0.504	0.11
135_K	138_D	0.504	0.11
172_T	181_R	0.504	0.11
132_S	202_P	0.503	0.11
44_T	87_L	0.503	0.11
75_A	200_Q	0.502	0.11
242_M	248_M	0.501	0.11
168_K	231_S	0.501	0.11
150_T	200_Q	0.500	0.11

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2yx0A	1	0.8685	100	0.643	Contact Map
2z2uA	1	0.7616	100	0.659	Contact Map
3c8fA	1	0.6384	99.8	0.883	Contact Map
3rfaA	1	0.8137	99.8	0.891	Contact Map
3canA	2	0.4247	99.7	0.899	Contact Map
1tv8A	2	0.7534	99.6	0.908	Contact Map
2qgqA	1	0.6438	99.4	0.917	Contact Map
4k36A	1	0.6712	99.4	0.918	Contact Map
4rtbA	2	0.8795	99.3	0.92	Contact Map
4wcxA	1	0.874	99.2	0.925	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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