GREMLIN Database
GATA - Glutamyl-tRNA(Gln) amidotransferase subunit A
UniProt: Q97ZG1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 478 (440)
Sequences: 14609 (10347)
Seq/√Len: 493.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_E52_K4.1951.00
97_D105_K4.1271.00
275_N278_S3.2371.00
256_S286_D2.9291.00
388_I458_I2.8961.00
139_D142_R2.8911.00
126_T149_G2.8471.00
97_D102_E2.8451.00
429_L459_S2.8371.00
162_L219_L2.7851.00
32_G46_S2.7771.00
448_K451_S2.7051.00
12_D18_L2.6851.00
54_V65_A2.6591.00
210_A216_L2.6291.00
151_S163_A2.5901.00
102_E106_K2.5471.00
451_S454_Y2.5201.00
181_I209_M2.4441.00
45_R48_E2.4381.00
421_A446_M2.3611.00
12_D17_N2.3541.00
20_A55_K2.3321.00
447_G451_S2.2911.00
28_Y46_S2.2441.00
285_E386_Y2.2301.00
172_I183_G2.2291.00
43_T81_R2.2031.00
253_G386_Y2.1741.00
104_L109_A2.1361.00
21_E25_E2.1361.00
182_F216_L2.1111.00
69_I162_L2.0951.00
62_G65_A2.0831.00
251_R283_L2.0581.00
267_S271_K2.0541.00
57_S65_A2.0471.00
45_R80_I2.0211.00
460_S464_R2.0041.00
71_I101_I1.9931.00
252_I388_I1.9901.00
11_N15_N1.9641.00
214_E460_S1.9581.00
447_G455_L1.9361.00
137_P179_N1.9121.00
217_G460_S1.9011.00
445_L455_L1.8961.00
9_L23_Y1.8941.00
126_T134_T1.8711.00
5_M8_D1.8561.00
70_A115_T1.8471.00
28_Y44_I1.8461.00
41_F70_A1.8381.00
361_Y364_F1.8191.00
103_K225_G1.8181.00
254_V274_V1.7631.00
184_L452_D1.7611.00
428_A446_M1.7601.00
63_K107_E1.7261.00
34_Y159_Y1.7141.00
142_R439_L1.7001.00
81_R91_D1.6891.00
182_F213_A1.6561.00
31_I159_Y1.6501.00
212_N215_D1.6471.00
13_L23_Y1.6411.00
397_L436_Y1.6321.00
10_V14_R1.6291.00
155_L209_M1.6241.00
400_K403_E1.6161.00
76_S82_T1.6131.00
390_L445_L1.6061.00
142_R400_K1.5861.00
38_I157_A1.5861.00
141_E400_K1.5771.00
82_T114_K1.5771.00
182_F429_L1.5681.00
274_V284_I1.5661.00
70_A160_V1.5601.00
257_D288_K1.5411.00
84_C197_V1.5391.00
7_V214_E1.5341.00
276_K279_S1.5311.00
69_I111_I1.5281.00
25_E29_E1.5271.00
393_T430_S1.5201.00
75_I206_I1.4931.00
191_V223_I1.4921.00
184_L456_I1.4821.00
6_I162_L1.4821.00
462_I466_I1.4761.00
269_V441_I1.4671.00
24_I110_V1.4651.00
74_N117_M1.4601.00
49_E52_K1.4571.00
39_N132_G1.4561.00
190_T220_F1.4561.00
10_V67_V1.4541.00
182_F463_E1.4531.00
238_L241_E1.4481.00
38_I153_A1.4461.00
50_V105_K1.4341.00
107_E222_I1.4261.00
73_D114_K1.4171.00
196_L206_I1.4161.00
56_E60_K1.4131.00
50_V53_E1.4131.00
70_A154_A1.4091.00
52_K56_E1.4031.00
185_K422_N1.4021.00
391_S446_M1.3971.00
99_T102_E1.3901.00
165_G209_M1.3891.00
9_L161_E1.3891.00
75_I164_L1.3701.00
274_V390_L1.3661.00
43_T80_I1.3631.00
74_N121_A1.3571.00
275_N279_S1.3571.00
380_D449_Y1.3481.00
20_A24_I1.3471.00
271_K275_N1.3471.00
138_W435_F1.3471.00
152_G179_N1.3461.00
31_I44_I1.3331.00
105_K111_I1.3311.00
127_E402_G1.3281.00
178_Y394_M1.3271.00
29_E33_K1.3131.00
135_R401_I1.3091.00
256_S271_K1.3021.00
249_N283_L1.2941.00
58_I61_G1.2931.00
24_I112_I1.2871.00
269_V434_G1.2821.00
247_V282_A1.2811.00
426_I446_M1.2781.00
53_E57_S1.2741.00
381_E384_K1.2701.00
116_N128_T1.2681.00
48_E80_I1.2641.00
87_K90_E1.2621.00
31_I112_I1.2551.00
45_R50_V1.2551.00
285_E385_K1.2541.00
176_A209_M1.2511.00
49_E53_E1.2461.00
100_V164_L1.2461.00
262_S417_N1.2451.00
234_I450_L1.2451.00
153_A157_A1.2341.00
280_E465_N1.2341.00
268_G272_D1.2311.00
10_V13_L1.2261.00
221_S240_F1.2261.00
145_G174_A1.2221.00
148_S151_S1.2221.00
273_V443_L1.2211.00
216_L456_I1.2191.00
30_K34_Y1.2131.00
53_E56_E1.2111.00
27_T112_I1.2011.00
76_S94_P1.2011.00
13_L58_I1.2001.00
346_K350_L1.1941.00
251_R285_E1.1921.00
269_V433_V1.1911.00
298_A371_V1.1901.00
135_R140_L1.1861.00
99_T103_K1.1851.00
68_L161_E1.1831.00
187_S449_Y1.1791.00
5_M214_E1.1761.00
21_E55_K1.1751.00
6_I67_V1.1711.00
172_I208_P1.1711.00
428_A444_Q1.1691.00
41_F113_G1.1691.00
77_T82_T1.1661.00
19_E22_E1.1651.00
76_S92_Y1.1591.00
70_A151_S1.1571.00
164_L223_I1.1571.00
429_L455_L1.1531.00
273_V462_I1.1521.00
337_R340_A1.1521.00
167_D173_R1.1491.00
208_P219_L1.1461.00
35_D159_Y1.1461.00
180_A435_F1.1361.00
77_T94_P1.1351.00
249_N282_A1.1281.00
102_E105_K1.1211.00
64_L109_A1.1161.00
16_K59_N1.1121.00
35_D40_A1.1111.00
80_I94_P1.1111.00
133_P401_I1.1101.00
42_I85_A1.1081.00
158_G211_R1.1031.00
103_K106_K1.1031.00
213_A463_E1.0951.00
42_I116_N1.0851.00
430_S442_G1.0841.00
7_V218_L1.0841.00
190_T224_A1.0831.00
16_K58_I1.0801.00
5_M212_N1.0721.00
265_P436_Y1.0721.00
184_L220_F1.0701.00
270_I274_V1.0681.00
13_L20_A1.0641.00
27_T159_Y1.0621.00
294_Y371_V1.0561.00
287_T382_L1.0551.00
377_K381_E1.0531.00
86_S120_F1.0521.00
70_A163_A1.0521.00
77_T114_K1.0481.00
266_V441_I1.0471.00
165_G172_I1.0441.00
421_A428_A1.0411.00
250_V454_Y1.0411.00
250_V458_I1.0401.00
274_V278_S1.0401.00
264_K268_G1.0381.00
378_N381_E1.0341.00
100_V206_I1.0311.00
155_L163_A1.0211.00
77_T80_I1.0201.00
202_S306_E1.0171.00
54_V58_I1.0151.00
250_V282_A1.0151.00
252_I390_L1.0141.00
27_T161_E1.0141.00
78_E97_D1.0141.00
252_I282_A1.0131.00
28_Y32_G1.0111.00
272_D275_N1.0101.00
81_R93_I1.0101.00
247_V250_V1.0091.00
276_K280_E0.9991.00
445_L458_I0.9981.00
99_T194_F0.9931.00
20_A65_A0.9911.00
27_T160_V0.9901.00
48_E105_K0.9901.00
178_Y398_P0.9901.00
54_V57_S0.9891.00
278_S283_L0.9881.00
184_L429_L0.9871.00
187_S452_D0.9871.00
166_S206_I0.9871.00
256_S288_K0.9861.00
374_L378_N0.9861.00
71_I111_I0.9851.00
269_V272_D0.9721.00
117_M121_A0.9651.00
96_Y102_E0.9651.00
134_T153_A0.9621.00
102_E229_R0.9611.00
160_V163_A0.9601.00
365_Y369_L0.9591.00
262_S267_S0.9561.00
376_K380_D0.9541.00
134_T144_P0.9531.00
58_I65_A0.9531.00
272_D276_K0.9471.00
137_P153_A0.9381.00
116_N131_F0.9371.00
38_I140_L0.9361.00
30_K33_K0.9301.00
184_L216_L0.9301.00
254_V270_I0.9301.00
253_G287_T0.9281.00
50_V54_V0.9271.00
37_Y140_L0.9251.00
291_N378_N0.9241.00
168_T204_E0.9211.00
253_G382_L0.9191.00
448_K454_Y0.9181.00
369_L372_R0.9161.00
371_V374_L0.9151.00
433_V441_I0.9141.00
115_T151_S0.9141.00
182_F431_M0.9111.00
453_I457_N0.9111.00
185_K205_Q0.9111.00
154_A159_Y0.9101.00
191_V220_F0.9021.00
381_E385_K0.9011.00
80_I114_K0.9001.00
98_A101_I0.9001.00
176_A183_G0.8991.00
75_I166_S0.8941.00
431_M445_L0.8921.00
18_L23_Y0.8891.00
19_E55_K0.8871.00
277_L462_I0.8871.00
41_F115_T0.8851.00
100_V191_V0.8831.00
32_G44_I0.8811.00
83_T91_D0.8771.00
213_A459_S0.8751.00
187_S450_L0.8731.00
177_A394_M0.8721.00
23_Y27_T0.8701.00
143_T178_Y0.8701.00
57_S61_G0.8691.00
75_I98_A0.8681.00
55_K59_N0.8681.00
77_T97_D0.8671.00
20_A54_V0.8651.00
6_I218_L0.8621.00
13_L18_L0.8621.00
135_R141_E0.8611.00
219_L223_I0.8601.00
69_I109_A0.8601.00
226_P233_T0.8601.00
250_V388_I0.8551.00
142_R398_P0.8541.00
75_I196_L0.8541.00
155_L181_I0.8531.00
31_I35_D0.8501.00
124_S174_A0.8431.00
178_Y414_M0.8421.00
35_D39_N0.8411.00
445_L462_I0.8381.00
433_V443_L0.8361.00
8_D12_D0.8361.00
276_K465_N0.8361.00
214_E463_E0.8351.00
194_F229_R0.8331.00
164_L206_I0.8331.00
276_K466_I0.8321.00
276_K462_I0.8311.00
373_N377_K0.8301.00
29_E32_G0.8251.00
384_K448_K0.8231.00
69_I219_L0.8221.00
301_I368_A0.8221.00
182_F459_S0.8191.00
347_R350_L0.8181.00
144_P153_A0.8161.00
220_F452_D0.8151.00
77_T111_I0.8151.00
24_I28_Y0.8141.00
70_A113_G0.8121.00
13_L65_A0.8101.00
177_A442_G0.8101.00
342_G345_V0.8071.00
436_Y441_I0.8051.00
9_L13_L0.8051.00
270_I433_V0.8041.00
264_K267_S0.8041.00
71_I77_T0.8041.00
41_F160_V0.8041.00
99_T192_S0.8021.00
6_I10_V0.8001.00
454_Y457_N0.7931.00
144_P179_N0.7901.00
372_R376_K0.7891.00
86_S119_E0.7891.00
366_L370_K0.7881.00
24_I27_T0.7881.00
152_G209_M0.7851.00
31_I41_F0.7841.00
169_G299_Y0.7841.00
377_K380_D0.7841.00
308_S353_S0.7811.00
388_I454_Y0.7811.00
172_I207_G0.7791.00
252_I277_L0.7781.00
190_T452_D0.7781.00
201_N310_N0.7741.00
380_D426_I0.7731.00
116_N132_G0.7731.00
96_Y194_F0.7711.00
26_R29_E0.7711.00
115_T154_A0.7701.00
74_N166_S0.7691.00
379_L424_A0.7591.00
380_D448_K0.7591.00
13_L67_V0.7571.00
364_F367_K0.7571.00
429_L456_I0.7561.00
71_I164_L0.7551.00
214_E218_L0.7521.00
452_D455_L0.7511.00
263_E397_L0.7511.00
388_I445_L0.7491.00
142_R399_P0.7481.00
103_K192_S0.7471.00
312_A316_G0.7451.00
23_Y67_V0.7401.00
217_G221_S0.7391.00
76_S96_Y0.7361.00
370_K374_L0.7351.00
20_A58_I0.7351.00
75_I100_V0.7271.00
8_D11_N0.7261.00
271_K278_S0.7231.00
14_R58_I0.7201.00
101_I111_I0.7181.00
76_S114_K0.7151.00
115_T163_A0.7141.00
143_T401_I0.7121.00
251_R386_Y0.7121.00
190_T453_I0.7121.00
174_A394_M0.7111.00
10_V218_L0.7091.00
268_G271_K0.7091.00
64_L218_L0.7081.00
374_L377_K0.7051.00
350_L353_S0.7051.00
151_S154_A0.7041.00
221_S237_N0.7041.00
118_D123_G0.7021.00
426_I449_Y0.7011.00
398_P439_L0.7001.00
10_V58_I0.7001.00
263_E436_Y0.6991.00
18_L22_E0.6971.00
255_L258_I0.6971.00
90_E130_Y0.6971.00
184_L455_L0.6941.00
63_K222_I0.6901.00
156_A181_I0.6901.00
12_D15_N0.6891.00
38_I159_Y0.6871.00
212_N216_L0.6871.00
383_F426_I0.6831.00
280_E461_F0.6831.00
277_L458_I0.6821.00
62_G107_E0.6791.00
390_L443_L0.6791.00
271_K286_D0.6781.00
6_I161_E0.6761.00
142_R437_S0.6751.00
278_S284_I0.6751.00
98_A195_G0.6741.00
294_Y297_P0.6731.00
57_S108_G0.6721.00
311_L314_Y0.6721.00
383_F448_K0.6701.00
6_I13_L0.6701.00
80_I111_I0.6691.00
35_D44_I0.6681.00
81_R90_E0.6671.00
254_V286_D0.6661.00
376_K449_Y0.6621.00
362_E365_Y0.6601.00
191_V208_P0.6601.00
84_C89_L0.6601.00
34_Y157_A0.6581.00
299_Y303_A0.6571.00
421_A426_I0.6561.00
397_L437_S0.6551.00
220_F456_I0.6541.00
396_I414_M0.6521.00
266_V397_L0.6511.00
40_A159_Y0.6481.00
35_D41_F0.6471.00
166_S196_L0.6451.00
265_P437_S0.6441.00
265_P269_V0.6431.00
99_T229_R0.6431.00
25_E52_K0.6421.00
362_E366_L0.6411.00
52_K55_K0.6411.00
407_D410_R0.6411.00
308_S312_A0.6411.00
391_S428_A0.6401.00
41_F44_I0.6401.00
199_Y303_A0.6381.00
138_W156_A0.6351.00
77_T105_K0.6311.00
138_W180_A0.6311.00
243_K457_N0.6311.00
28_Y31_I0.6291.00
433_V462_I0.6281.00
162_L210_A0.6281.00
126_T144_P0.6271.00
11_N14_R0.6261.00
74_N84_C0.6261.00
287_T386_Y0.6261.00
259_L270_I0.6251.00
217_G457_N0.6251.00
460_S463_E0.6251.00
298_A375_I0.6241.00
40_A154_A0.6241.00
250_V457_N0.6231.00
289_L382_L0.6231.00
21_E51_L0.6231.00
382_L385_K0.6211.00
34_Y37_Y0.6211.00
9_L12_D0.6191.00
247_V461_F0.6191.00
263_E266_V0.6191.00
452_D456_I0.6191.00
72_K171_S0.6181.00
112_I160_V0.6171.00
7_V212_N0.6171.00
125_T143_T0.6171.00
246_S457_N0.6161.00
78_E96_Y0.6150.99
79_G93_I0.6140.99
373_N376_K0.6130.99
208_P223_I0.6120.99
242_L457_N0.6120.99
451_S455_L0.6120.99
379_L426_I0.6110.99
41_F159_Y0.6100.99
254_V284_I0.6080.99
360_Y364_F0.6070.99
178_Y399_P0.6070.99
190_T238_L0.6070.99
165_G208_P0.6070.99
72_K147_S0.6060.99
312_A367_K0.6050.99
431_M466_I0.6030.99
39_N134_T0.6020.99
218_L221_S0.6010.99
122_M307_A0.6010.99
193_R206_I0.6010.99
278_S286_D0.6000.99
273_V433_V0.5990.99
35_D134_T0.5990.99
164_L219_L0.5970.99
121_A168_T0.5970.99
226_P235_N0.5960.99
213_A460_S0.5950.99
22_E25_E0.5950.99
138_W440_P0.5930.99
65_A108_G0.5930.99
251_R387_D0.5930.99
313_R316_G0.5930.99
89_L92_Y0.5920.99
63_K221_S0.5910.99
253_G387_D0.5900.99
121_A204_E0.5900.99
218_L222_I0.5890.99
151_S164_L0.5890.99
87_K130_Y0.5890.99
277_L282_A0.5880.99
447_G454_Y0.5880.99
265_P441_I0.5870.99
253_G286_D0.5860.99
277_L280_E0.5850.99
431_M443_L0.5840.99
118_D126_T0.5840.99
42_I83_T0.5820.99
154_A160_V0.5800.99
245_R457_N0.5800.99
249_N461_F0.5800.99
263_E396_I0.5800.99
265_P397_L0.5790.99
188_Y205_Q0.5790.99
393_T442_G0.5770.99
116_N134_T0.5760.99
152_G156_A0.5760.99
7_V11_N0.5750.99
188_Y425_A0.5740.99
303_A306_E0.5740.99
187_S427_P0.5730.99
277_L390_L0.5720.99
360_Y365_Y0.5720.99
174_A418_T0.5720.99
51_L55_K0.5700.99
36_K39_N0.5680.99
282_A461_F0.5660.99
389_L446_M0.5630.99
280_E462_I0.5630.99
118_D149_G0.5630.99
397_L439_L0.5610.99
136_N144_P0.5610.99
454_Y458_I0.5610.99
82_T94_P0.5600.99
32_G36_K0.5580.99
56_E59_N0.5570.99
311_L341_F0.5560.99
127_E133_P0.5550.99
287_T389_L0.5550.99
153_A179_N0.5520.99
345_V348_R0.5520.99
238_L242_L0.5510.99
177_A393_T0.5500.99
77_T101_I0.5500.99
78_E95_P0.5490.99
27_T158_G0.5490.99
308_S352_G0.5480.99
252_I284_I0.5480.99
301_I364_F0.5440.99
9_L18_L0.5430.99
113_G154_A0.5430.99
193_R230_D0.5430.99
271_K274_V0.5420.99
133_P144_P0.5420.99
21_E24_I0.5420.99
393_T418_T0.5410.99
99_T227_D0.5380.99
237_N240_F0.5380.99
121_A166_S0.5370.99
55_K58_I0.5370.99
118_D125_T0.5360.99
265_P268_G0.5350.99
114_K117_M0.5350.99
16_K22_E0.5350.99
172_I209_M0.5340.99
135_R139_D0.5340.99
349_I352_G0.5340.99
104_L219_L0.5340.99
316_G353_S0.5330.99
87_K340_A0.5320.99
43_T114_K0.5320.99
338_G350_L0.5300.99
297_P301_I0.5260.98
303_A307_A0.5250.98
363_E367_K0.5240.98
109_A219_L0.5240.98
302_I368_A0.5230.98
63_K108_G0.5230.98
215_D218_L0.5230.98
34_Y38_I0.5230.98
305_S362_E0.5230.98
161_E215_D0.5230.98
367_K370_K0.5230.98
278_S281_G0.5220.98
311_L315_D0.5210.98
97_D101_I0.5210.98
302_I306_E0.5210.98
230_D233_T0.5190.98
306_E315_D0.5180.98
253_G383_F0.5180.98
10_V62_G0.5130.98
272_D466_I0.5130.98
246_S249_N0.5120.98
353_S359_G0.5120.98
172_I176_A0.5110.98
346_K349_I0.5100.98
347_R351_L0.5100.98
48_E78_E0.5090.98
399_P414_M0.5080.98
279_S465_N0.5070.98
341_F344_E0.5070.98
455_L458_I0.5070.98
128_T132_G0.5070.98
125_T399_P0.5060.98
388_I447_G0.5050.98
225_G233_T0.5050.98
220_F224_A0.5040.98
270_I443_L0.5040.98
94_P114_K0.5040.98
21_E56_E0.5030.98
125_T404_V0.5030.98
83_T90_E0.5030.98
9_L27_T0.5020.98
211_R215_D0.5010.98
67_V161_E0.5000.98
217_G456_I0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ip4A 1 0.9937 100 0.081 Contact Map
4wj3A 1 0.9937 100 0.081 Contact Map
3h0lA 1 0.9874 100 0.088 Contact Map
3kfuE 1 0.9686 100 0.096 Contact Map
2gi3A 2 0.9268 100 0.107 Contact Map
1m22A 1 0.954 100 0.123 Contact Map
3a2qA 2 0.9414 100 0.124 Contact Map
2dc0A 2 0.887 100 0.129 Contact Map
4cp8A 2 0.9226 100 0.142 Contact Map
4gysA 2 0.9184 100 0.143 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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