GREMLIN Database
Q97ZF9 - DNA repair protein rad25
UniProt: Q97ZF9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 551 (467)
Sequences: 7262 (5329)
Seq/√Len: 246.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
197_I224_I4.2071.00
416_G480_N3.9201.00
224_I247_I3.7691.00
274_V296_G3.6171.00
344_R518_S3.2701.00
171_A195_V2.8181.00
335_S509_Q2.8081.00
314_L324_V2.6981.00
429_E439_L2.6981.00
321_Y324_V2.6491.00
314_L321_Y2.6111.00
324_V328_A2.5461.00
318_I321_Y2.5291.00
324_V327_L2.5181.00
60_Y63_R2.4561.00
318_I322_K2.4161.00
47_G50_P2.4121.00
314_L322_K2.3731.00
422_T428_A2.3611.00
61_D64_L2.2701.00
318_I324_V2.2381.00
411_L418_I2.2041.00
200_I207_T2.1331.00
59_D63_R2.1241.00
84_E87_K2.1191.00
328_A331_G2.0631.00
50_P53_I2.0551.00
68_D71_T2.0331.00
422_T431_I2.0291.00
431_I485_V2.0251.00
482_G501_I2.0021.00
196_G270_I1.9921.00
451_R455_T1.9911.00
44_K47_G1.9761.00
432_A437_S1.9731.00
83_I87_K1.9271.00
280_D283_K1.9271.00
60_Y64_L1.9251.00
51_N54_V1.9181.00
46_N50_P1.9151.00
88_I91_K1.9121.00
221_K225_L1.9081.00
406_A409_E1.9051.00
314_L318_I1.8991.00
93_Y96_L1.8981.00
45_R49_K1.8951.00
45_R48_V1.8891.00
62_V65_S1.8871.00
258_H262_L1.8771.00
432_A436_N1.8671.00
66_Q69_I1.8651.00
457_K478_D1.8541.00
55_E58_E1.8291.00
92_P95_Y1.7971.00
68_D72_L1.7881.00
536_S541_S1.7811.00
69_I72_L1.7811.00
63_R66_Q1.7711.00
407_L411_L1.7671.00
119_D122_N1.7611.00
222_E454_V1.7111.00
85_A88_I1.6821.00
49_K53_I1.6771.00
445_S448_E1.6731.00
53_I56_I1.6721.00
49_K52_E1.6551.00
337_E509_Q1.6551.00
319_I324_V1.6411.00
117_R121_Q1.6351.00
67_E71_T1.6311.00
98_D101_E1.6301.00
95_Y98_D1.6171.00
156_F159_E1.6051.00
117_R120_K1.5941.00
90_M93_Y1.5881.00
140_R143_G1.5871.00
67_E70_A1.5861.00
517_V520_T1.5851.00
314_L320_Y1.5811.00
106_K110_S1.5711.00
118_Y122_N1.5631.00
46_N49_K1.5531.00
432_A439_L1.5471.00
121_Q124_R1.5431.00
47_G53_I1.5431.00
175_W295_M1.5301.00
109_N112_H1.5291.00
259_L262_L1.5251.00
253_H276_H1.5231.00
97_A100_L1.5221.00
94_T97_A1.5141.00
221_K249_I1.5111.00
425_I443_K1.5081.00
86_G89_I1.5031.00
64_L67_E1.5021.00
47_G51_N1.4851.00
418_I483_I1.4851.00
48_V51_N1.4811.00
96_L99_V1.4721.00
143_G148_E1.4691.00
481_V513_Y1.4691.00
100_L103_I1.4671.00
52_E55_E1.4631.00
320_Y324_V1.4461.00
223_A226_K1.4391.00
54_V58_E1.4371.00
111_E114_F1.4281.00
65_S68_D1.4251.00
388_R391_N1.4221.00
58_E61_D1.4141.00
59_D62_V1.4091.00
217_M249_I1.4021.00
210_V250_T1.4001.00
112_H115_K1.3941.00
113_R116_I1.3941.00
55_E59_D1.3891.00
84_E88_I1.3851.00
142_N145_E1.3811.00
111_E115_K1.3731.00
470_G474_I1.3621.00
438_L452_V1.3581.00
56_I59_D1.3531.00
59_D65_S1.3491.00
63_R67_E1.3461.00
269_L291_A1.3461.00
322_K327_L1.3461.00
248_T266_F1.3431.00
85_A90_M1.3311.00
172_I198_K1.3311.00
285_I289_L1.3221.00
410_I483_I1.3201.00
200_I232_P1.3161.00
48_V55_E1.3121.00
282_F285_I1.3101.00
135_L138_K1.3041.00
92_P96_L1.3011.00
408_D434_R1.2891.00
62_V68_D1.2851.00
438_L455_T1.2821.00
321_Y327_L1.2821.00
498_L512_L1.2791.00
339_I511_K1.2781.00
265_K290_I1.2721.00
237_Y258_H1.2701.00
61_D65_S1.2681.00
407_L483_I1.2651.00
138_K141_E1.2651.00
63_R69_I1.2631.00
52_E61_D1.2531.00
83_I86_G1.2531.00
56_I66_Q1.2521.00
56_I62_V1.2501.00
323_S327_L1.2491.00
99_V102_K1.2461.00
444_M452_V1.2411.00
66_Q70_A1.2361.00
101_E104_N1.2341.00
91_K96_L1.2341.00
122_N125_F1.2321.00
64_L70_A1.2281.00
392_E395_K1.2271.00
318_I327_L1.2221.00
139_L142_N1.2211.00
136_L139_L1.2181.00
450_K454_V1.2171.00
152_S155_E1.2061.00
216_Q473_G1.2031.00
44_K49_K1.2021.00
143_G146_V1.1971.00
61_D67_E1.1931.00
50_P54_V1.1911.00
57_L63_R1.1881.00
49_K55_E1.1801.00
44_K48_V1.1781.00
91_K94_T1.1781.00
87_K91_K1.1761.00
410_I513_Y1.1691.00
53_I57_L1.1681.00
56_I61_D1.1661.00
51_N56_I1.1651.00
72_L76_L1.1621.00
455_T459_M1.1621.00
93_Y99_V1.1611.00
59_D64_L1.1551.00
64_L72_L1.1481.00
419_L501_I1.1441.00
176_I202_I1.1441.00
196_G297_L1.1431.00
132_Y135_L1.1421.00
109_N113_R1.1391.00
115_K119_D1.1381.00
460_N463_V1.1371.00
65_S71_T1.1351.00
323_S326_E1.1341.00
250_T255_A1.1271.00
64_L68_D1.1271.00
91_K97_A1.1141.00
127_V130_M1.1121.00
60_Y66_Q1.1121.00
88_I92_P1.1111.00
283_K287_E1.1091.00
60_Y65_S1.1091.00
132_Y136_L1.1071.00
119_D123_R1.1071.00
234_I249_I1.1061.00
101_E105_G1.1061.00
157_E160_F1.1061.00
45_R50_P1.1051.00
141_E144_L1.1051.00
71_T76_L1.1041.00
57_L64_L1.1001.00
93_Y97_A1.0911.00
49_K62_V1.0911.00
88_I94_T1.0871.00
44_K51_N1.0861.00
175_W182_G1.0831.00
108_E111_E1.0831.00
319_I322_K1.0821.00
343_V402_E1.0821.00
175_W199_G1.0781.00
324_V331_G1.0781.00
115_K118_Y1.0761.00
337_E511_K1.0751.00
316_G319_I1.0731.00
44_K50_P1.0721.00
99_V103_I1.0661.00
63_R68_D1.0611.00
110_S113_R1.0611.00
308_H312_F1.0601.00
120_K123_R1.0591.00
197_I247_I1.0581.00
201_D228_T1.0581.00
53_I60_Y1.0551.00
466_L469_V1.0551.00
91_K95_Y1.0511.00
130_M135_L1.0451.00
53_I59_D1.0441.00
58_E63_R1.0411.00
46_N54_V1.0411.00
118_Y123_R1.0401.00
56_I60_Y1.0391.00
59_D66_Q1.0381.00
453_L474_I1.0351.00
438_L461_A1.0341.00
232_P246_P1.0301.00
60_Y70_A1.0281.00
219_Q475_D1.0271.00
416_G481_V1.0221.00
86_G92_P1.0191.00
131_D136_L1.0181.00
152_S156_F1.0171.00
85_A89_I1.0141.00
86_G90_M1.0131.00
89_I92_P1.0091.00
126_I129_P1.0081.00
197_I228_T1.0011.00
356_L396_I0.9991.00
155_E159_E0.9981.00
57_L60_Y0.9941.00
435_Y463_V0.9921.00
140_R144_L0.9861.00
85_A92_P0.9851.00
153_F156_F0.9841.00
87_K90_M0.9821.00
62_V66_Q0.9821.00
59_D68_D0.9811.00
282_F286_A0.9811.00
46_N52_E0.9811.00
271_V277_L0.9801.00
50_P56_I0.9801.00
307_K312_F0.9771.00
322_K328_A0.9761.00
64_L69_I0.9741.00
57_L66_Q0.9721.00
267_Y292_P0.9711.00
320_Y327_L0.9701.00
269_L289_L0.9661.00
155_E158_F0.9651.00
216_Q219_Q0.9621.00
138_K142_N0.9571.00
137_Q141_E0.9551.00
410_I515_I0.9521.00
62_V70_A0.9501.00
316_G320_Y0.9491.00
66_Q71_T0.9481.00
442_G449_R0.9431.00
237_Y240_E0.9431.00
55_E61_D0.9411.00
129_P133_F0.9411.00
425_I429_E0.9401.00
327_L331_G0.9381.00
93_Y98_D0.9371.00
211_T251_T0.9351.00
221_K236_L0.9321.00
60_Y69_I0.9311.00
114_F118_Y0.9281.00
484_I498_L0.9261.00
534_I538_E0.9231.00
88_I95_Y0.9211.00
114_F117_R0.9191.00
61_D68_D0.9191.00
196_G295_M0.9181.00
65_S69_I0.9181.00
154_K157_E0.9141.00
145_E148_E0.9121.00
213_T253_H0.9111.00
124_R127_V0.9101.00
528_K531_E0.9081.00
98_D102_K0.9061.00
252_Y271_V0.9051.00
420_I463_V0.9051.00
67_E72_L0.9041.00
483_I515_I0.9041.00
347_L351_K0.9021.00
281_K284_L0.9011.00
143_G147_K0.8991.00
53_I65_S0.8991.00
314_L328_A0.8981.00
454_V458_T0.8961.00
58_E62_V0.8961.00
200_I224_I0.8951.00
97_A104_N0.8951.00
69_I76_L0.8941.00
113_R117_R0.8931.00
353_Y356_L0.8901.00
106_K109_N0.8901.00
48_V54_V0.8891.00
48_V52_E0.8881.00
94_T98_D0.8861.00
125_F129_P0.8851.00
304_E307_K0.8841.00
211_T220_W0.8821.00
84_E89_I0.8811.00
309_N312_F0.8781.00
275_H472_E0.8771.00
61_D66_Q0.8771.00
131_D134_N0.8771.00
50_P55_E0.8730.99
279_A282_F0.8700.99
56_I68_D0.8680.99
117_R122_N0.8680.99
114_F119_D0.8670.99
45_R51_N0.8630.99
57_L71_T0.8620.99
345_L353_Y0.8600.99
128_R132_Y0.8580.99
121_Q125_F0.8570.99
268_L295_M0.8560.99
281_K285_I0.8550.99
115_K120_K0.8550.99
66_Q72_L0.8520.99
96_L100_L0.8490.99
83_I88_I0.8480.99
54_V61_D0.8470.99
448_E451_R0.8460.99
89_I94_T0.8440.99
131_D142_N0.8420.99
86_G93_Y0.8410.99
58_E65_S0.8350.99
403_K407_L0.8330.99
110_S114_F0.8280.99
116_I119_D0.8260.99
53_I58_E0.8260.99
236_L249_I0.8250.99
120_K124_R0.8250.99
531_E534_I0.8250.99
133_F139_L0.8240.99
46_N56_I0.8230.99
53_I70_A0.8230.99
45_R57_L0.8220.99
56_I63_R0.8210.99
100_L104_N0.8190.99
54_V59_D0.8170.99
142_N149_L0.8170.99
57_L62_V0.8140.99
46_N51_N0.8110.99
346_T349_E0.8100.99
90_M94_T0.8100.99
86_G91_K0.8090.99
47_G60_Y0.8090.99
238_Y241_E0.8060.99
50_P64_L0.8060.99
352_R355_E0.8040.99
314_L319_I0.8040.99
420_I483_I0.8040.99
345_L520_T0.8030.99
126_I131_D0.8030.99
142_N148_E0.8020.99
44_K66_Q0.8010.99
102_K105_G0.8010.99
166_E170_E0.7990.99
324_V329_K0.7970.99
61_D70_A0.7970.99
196_G199_G0.7950.99
65_S72_L0.7940.99
350_R354_N0.7940.99
140_R149_L0.7930.99
84_E98_D0.7930.99
317_G320_Y0.7920.99
428_A432_A0.7870.99
84_E90_M0.7860.99
55_E65_S0.7850.99
141_E145_E0.7850.99
127_V131_D0.7840.99
255_A286_A0.7840.99
429_E432_A0.7820.99
352_R356_L0.7820.99
314_L327_L0.7820.99
323_S328_A0.7790.99
84_E93_Y0.7780.99
47_G63_R0.7770.99
125_F128_R0.7750.99
123_R126_I0.7720.99
89_I93_Y0.7720.99
67_E76_L0.7660.99
394_R424_Y0.7640.99
174_N182_G0.7610.99
139_L143_G0.7610.99
44_K58_E0.7600.99
216_Q474_I0.7590.99
318_I328_A0.7580.99
233_D246_P0.7570.99
390_Y521_P0.7550.99
44_K60_Y0.7540.98
94_T101_E0.7510.98
52_E62_V0.7500.98
258_H261_Q0.7500.98
141_E146_V0.7500.98
138_K143_G0.7480.98
47_G62_V0.7470.98
407_L485_V0.7440.98
342_K518_S0.7440.98
52_E59_D0.7440.98
113_R118_Y0.7430.98
530_K534_I0.7400.98
54_V64_L0.7400.98
65_S70_A0.7400.98
51_N63_R0.7400.98
403_K411_L0.7400.98
92_P98_D0.7370.98
114_F120_K0.7370.98
333_L336_Y0.7360.98
345_L517_V0.7350.98
57_L61_D0.7350.98
94_T100_L0.7330.98
488_T494_F0.7330.98
85_A91_K0.7290.98
313_S318_I0.7280.98
62_V67_E0.7270.98
54_V67_E0.7230.98
45_R60_Y0.7230.98
143_G149_L0.7220.98
90_M100_L0.7210.98
142_N146_V0.7190.98
484_I487_G0.7170.98
87_K92_P0.7150.98
111_E118_Y0.7140.98
313_S316_G0.7140.98
44_K64_L0.7140.98
49_K57_L0.7110.98
90_M95_Y0.7110.98
200_I209_I0.7100.98
146_V149_L0.7080.98
54_V62_V0.7070.98
56_I67_E0.7060.98
49_K56_I0.7060.98
56_I65_S0.7040.98
279_A283_K0.7040.98
324_V330_L0.7020.98
144_L147_K0.7000.98
112_H119_D0.7000.98
45_R59_D0.6970.98
52_E58_E0.6970.98
188_T299_A0.6970.98
253_H256_Y0.6960.97
52_E56_I0.6940.97
222_E226_K0.6940.97
321_Y331_G0.6940.97
325_T330_L0.6930.97
345_L349_E0.6930.97
96_L102_K0.6920.97
55_E62_V0.6920.97
135_L143_G0.6920.97
500_R503_R0.6910.97
47_G61_D0.6900.97
139_L145_E0.6890.97
95_Y100_L0.6880.97
127_V132_Y0.6870.97
430_E434_R0.6870.97
140_R145_E0.6850.97
235_G238_Y0.6840.97
130_M134_N0.6830.97
46_N53_I0.6830.97
116_I121_Q0.6820.97
135_L139_L0.6820.97
49_K60_Y0.6810.97
97_A102_K0.6810.97
426_D429_E0.6810.97
48_V56_I0.6800.97
320_Y323_S0.6790.97
338_I341_K0.6780.97
291_A294_R0.6760.97
48_V53_I0.6760.97
77_L83_I0.6760.97
316_G328_A0.6750.97
241_E244_I0.6740.97
238_Y242_K0.6740.97
159_E162_G0.6740.97
245_R248_T0.6700.97
63_R70_A0.6690.97
259_L263_F0.6680.97
215_E469_V0.6680.97
88_I93_Y0.6670.97
495_I533_D0.6660.97
58_E72_L0.6660.97
308_H311_L0.6650.97
45_R63_R0.6640.97
62_V76_L0.6630.97
83_I90_M0.6630.97
99_V104_N0.6620.97
122_N129_P0.6600.97
466_L470_G0.6580.96
77_L85_A0.6570.96
61_D71_T0.6550.96
425_I466_L0.6510.96
92_P97_A0.6500.96
124_R128_R0.6490.96
260_P263_F0.6460.96
336_Y340_Q0.6420.96
129_P132_Y0.6420.96
59_D70_A0.6400.96
540_M543_S0.6390.96
133_F138_K0.6390.96
53_I63_R0.6390.96
44_K56_I0.6380.96
213_T446_K0.6380.96
112_H117_R0.6380.96
321_Y328_A0.6370.96
336_Y339_I0.6360.96
388_R392_E0.6350.96
49_K58_E0.6340.96
354_N357_L0.6340.96
128_R133_F0.6340.96
118_Y138_K0.6310.96
87_K94_T0.6310.96
95_Y99_V0.6300.95
49_K69_I0.6290.95
380_D383_A0.6280.95
48_V63_R0.6280.95
344_R350_R0.6250.95
327_L330_L0.6240.95
132_Y139_L0.6240.95
121_Q132_Y0.6220.95
44_K59_D0.6220.95
87_K95_Y0.6210.95
387_M391_N0.6190.95
407_L420_I0.6160.95
62_V69_I0.6160.95
45_R55_E0.6150.95
123_R128_R0.6150.95
57_L69_I0.6130.95
115_K126_I0.6130.95
284_L288_G0.6130.95
236_L240_E0.6110.95
417_K478_D0.6100.95
60_Y71_T0.6100.95
47_G55_E0.6100.95
61_D105_G0.6080.95
125_F130_M0.6080.95
56_I72_L0.6070.95
481_V511_K0.6070.95
521_P525_Q0.6070.95
126_I132_Y0.6060.94
109_N118_Y0.6050.94
46_N60_Y0.6050.94
527_K531_E0.6040.94
137_Q145_E0.6040.94
318_I326_E0.6030.94
94_T99_V0.5980.94
240_E243_R0.5980.94
403_K410_I0.5970.94
90_M96_L0.5950.94
118_Y121_Q0.5930.94
501_I510_A0.5920.94
62_V72_L0.5920.94
382_S390_Y0.5920.94
136_L143_G0.5910.94
118_Y125_F0.5910.94
319_I328_A0.5900.94
534_I537_F0.5900.94
49_K61_D0.5890.94
88_I102_K0.5890.94
208_L269_L0.5880.94
134_N139_L0.5880.94
51_N55_E0.5870.93
533_D537_F0.5870.93
131_D135_L0.5860.93
418_I481_V0.5860.93
141_E148_E0.5850.93
106_K111_E0.5840.93
51_N60_Y0.5830.93
411_L420_I0.5810.93
207_T268_L0.5810.93
525_Q528_K0.5780.93
56_I64_L0.5780.93
137_Q143_G0.5770.93
52_E68_D0.5770.93
58_E64_L0.5750.93
54_V57_L0.5750.93
425_I428_A0.5740.93
124_R132_Y0.5740.93
86_G94_T0.5730.93
44_K54_V0.5730.93
440_L470_G0.5710.93
54_V68_D0.5710.93
52_E63_R0.5690.92
319_I323_S0.5690.92
125_F143_G0.5690.92
47_G57_L0.5690.92
453_L457_K0.5680.92
56_I71_T0.5680.92
215_E440_L0.5680.92
137_Q140_R0.5670.92
58_E66_Q0.5660.92
51_N71_T0.5660.92
114_F122_N0.5650.92
112_H125_F0.5630.92
54_V66_Q0.5630.92
468_T493_Q0.5610.92
105_G108_E0.5610.92
303_R307_K0.5600.92
44_K53_I0.5590.92
56_I70_A0.5580.92
138_K144_L0.5580.92
91_K100_L0.5570.92
224_I249_I0.5560.92
183_V311_L0.5550.91
319_I327_L0.5550.91
83_I92_P0.5540.91
156_F161_N0.5520.91
285_I288_G0.5510.91
480_N511_K0.5510.91
109_N115_K0.5500.91
423_Q427_Q0.5490.91
108_E112_H0.5480.91
274_V298_S0.5440.91
87_K93_Y0.5430.91
134_N140_R0.5410.90
92_P103_I0.5410.90
88_I96_L0.5400.90
314_L323_S0.5400.90
284_L287_E0.5390.90
403_K486_T0.5390.90
268_L293_Y0.5390.90
404_M485_V0.5380.90
52_E67_E0.5380.90
527_K534_I0.5370.90
130_M133_F0.5340.90
97_A101_E0.5330.90
132_Y140_R0.5310.90
85_A93_Y0.5290.89
387_M392_E0.5280.89
47_G65_S0.5280.89
340_Q343_V0.5260.89
200_I270_I0.5250.89
113_R124_R0.5230.89
115_K124_R0.5220.89
53_I64_L0.5210.89
120_K125_F0.5210.89
55_E68_D0.5200.89
391_N395_K0.5190.89
221_K234_I0.5190.89
162_G227_F0.5170.88
130_M145_E0.5160.88
45_R70_A0.5160.88
343_V406_A0.5150.88
45_R53_I0.5150.88
88_I101_E0.5140.88
530_K533_D0.5140.88
275_H496_Q0.5140.88
130_M136_L0.5120.88
129_P141_E0.5120.88
90_M99_V0.5100.88
53_I69_I0.5090.88
89_I95_Y0.5090.88
213_T251_T0.5080.87
51_N61_D0.5070.87
451_R454_V0.5070.87
51_N58_E0.5060.87
405_K408_D0.5050.87
339_I342_K0.5030.87
527_K530_K0.5020.87
121_Q135_L0.5020.87
135_L142_N0.5020.87
381_E385_E0.5010.87
140_R148_E0.5010.87
428_A439_L0.5010.87
93_Y100_L0.5010.87
452_V461_A0.5000.87
484_I514_E0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mwyW 2 0.902 100 0.381 Contact Map
1z3iX 4 0.7786 100 0.396 Contact Map
1z63A 1 0.6969 100 0.404 Contact Map
2fwrA 1 0.775 100 0.449 Contact Map
1wp9A 1 0.6697 100 0.48 Contact Map
4a2qA 1 0.8076 100 0.488 Contact Map
4qu4A 1 0.7477 100 0.491 Contact Map
2ykgA 1 0.6425 100 0.493 Contact Map
4a2pA 1 0.6134 100 0.495 Contact Map
4a2wA 1 0.7768 100 0.495 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0138 seconds.