GREMLIN Database
Q97ZF2 - tRNA-splicing ligase RtcB
UniProt: Q97ZF2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 482 (384)
Sequences: 1390 (836)
Seq/√Len: 42.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
338_E347_K4.9861.00
415_A419_N4.7391.00
415_A418_R4.4891.00
86_G346_K3.9221.00
206_F380_P3.7031.00
238_T302_I3.6241.00
104_L389_V3.5221.00
48_A63_V3.3411.00
111_Y211_V3.3021.00
211_V477_I3.0871.00
414_E418_R3.0611.00
391_A469_K2.9821.00
262_Y275_P2.8961.00
403_A468_A2.8641.00
258_A280_E2.8501.00
44_T67_G2.7861.00
357_R375_Q2.7441.00
245_H249_S2.7341.00
422_A445_A2.7241.00
454_D457_R2.7161.00
48_A61_I2.6901.00
57_V61_I2.6871.00
112_K230_G2.5511.00
50_N268_D2.5391.00
63_V67_G2.5271.00
184_K283_D2.4781.00
124_E312_R2.4661.00
125_L207_L2.4181.00
391_A471_V2.3901.00
123_E437_R2.3861.00
103_R328_D2.3851.00
129_V306_T2.3681.00
147_D190_K2.3181.00
43_M46_R2.3021.00
41_Q44_T2.3001.00
378_L389_V2.2791.00
386_A473_R2.2781.00
133_V202_A2.2741.00
128_N309_S2.2701.00
357_R372_N2.2641.00
211_V475_R2.2261.00
150_L243_L2.2001.00
234_V306_T2.1811.00
382_S385_T2.1561.00
89_V285_F2.1410.99
58_Q348_V2.1020.99
247_V291_G2.0870.99
420_Y448_A2.0700.99
460_K470_L2.0600.99
242_G245_H2.0420.99
111_Y230_G2.0310.99
75_I94_I1.9960.99
254_I280_E1.9840.99
129_V302_I1.9800.99
258_A262_Y1.9640.99
105_L303_T1.9340.99
393_I469_K1.9180.99
210_Q235_M1.9160.99
111_Y115_K1.8980.99
125_L306_T1.8730.99
122_V478_G1.8720.99
124_E127_R1.8580.99
336_I347_K1.8530.99
101_G299_R1.8360.98
234_V310_F1.8050.98
125_L129_V1.8000.98
106_R324_S1.7330.98
277_E282_Q1.7240.98
428_T450_G1.6940.97
457_R460_K1.6930.97
258_A261_K1.6900.97
326_V389_V1.6720.97
417_V442_R1.6720.97
110_D231_Q1.6530.97
105_L323_L1.6350.97
43_M415_A1.6130.96
285_F289_A1.6120.96
232_V477_I1.6100.96
111_Y477_I1.5970.96
278_S281_G1.5780.96
108_N321_L1.5650.96
106_R326_V1.5570.96
255_M274_V1.5100.95
207_L306_T1.5100.95
51_V69_Q1.4990.95
395_E398_R1.4960.94
234_V307_R1.4910.94
148_Q151_A1.4900.94
142_T145_Q1.4550.94
51_V93_G1.4450.93
384_G387_S1.4450.93
425_V448_A1.4280.93
200_L207_L1.4260.93
420_Y424_V1.4060.92
256_E269_R1.4030.92
385_T388_Y1.3990.92
51_V61_I1.3750.92
460_K464_E1.3620.91
429_L479_V1.3550.91
420_Y450_G1.3510.91
43_M69_Q1.3460.91
436_V444_V1.3440.91
389_V474_L1.3440.91
350_V357_R1.3380.90
261_K280_E1.3370.90
89_V324_S1.3320.90
99_N296_W1.3200.90
206_F294_F1.3080.89
74_P77_G1.2850.88
376_I471_V1.2750.88
109_L113_D1.2730.88
108_N231_Q1.2710.88
117_K120_Q1.2650.88
372_N375_Q1.2610.88
73_F93_G1.2570.87
104_L233_M1.2390.87
58_Q346_K1.2240.86
288_M334_A1.2230.86
168_M171_M1.2190.86
336_I349_L1.2060.85
460_K465_V1.2050.85
276_F281_G1.2040.85
42_D46_R1.2030.85
407_A449_P1.1980.85
399_T467_I1.1950.85
420_Y425_V1.1850.84
151_A182_P1.1830.84
292_A333_I1.1810.84
228_H472_M1.1800.84
114_V314_F1.1770.84
106_R325_I1.1760.84
167_D171_M1.1690.83
154_V171_M1.1670.83
124_E313_V1.1660.83
279_R283_D1.1650.83
276_F349_L1.1620.83
136_E199_T1.1550.82
91_P206_F1.1530.82
99_N330_A1.1430.82
146_L150_L1.1420.82
122_V435_V1.1390.82
171_M325_I1.1300.81
386_A456_D1.1140.80
45_L49_T1.1080.80
251_Y287_A1.1070.80
381_G387_S1.0970.79
119_A123_E1.0930.79
259_M264_I1.0930.79
376_I391_A1.0930.79
211_V232_V1.0920.79
261_K264_I1.0890.79
425_V428_T1.0820.78
270_E382_S1.0760.78
110_D228_H1.0750.78
99_N333_I1.0710.77
73_F79_A1.0700.77
334_A479_V1.0550.76
248_A252_L1.0550.76
106_R231_Q1.0520.76
264_I280_E1.0460.76
168_M172_E1.0360.75
108_N322_D1.0330.75
105_L236_V1.0330.75
129_V309_S1.0320.75
107_T323_L1.0280.74
39_M44_T1.0250.74
211_V230_G1.0250.74
388_Y455_V1.0210.74
149_V197_L1.0200.74
48_A67_G1.0180.74
388_Y456_D1.0170.74
356_T377_V1.0130.73
395_E466_K1.0110.73
335_K357_R1.0100.73
118_L478_G1.0090.73
51_V79_A1.0080.73
142_T146_L1.0040.73
67_G403_A1.0030.73
103_R327_Y1.0030.73
124_E309_S0.9980.72
42_D45_L0.9960.72
249_S253_Q0.9850.71
42_D49_T0.9850.71
118_L435_V0.9830.71
254_I283_D0.9830.71
149_V153_G0.9790.71
411_M416_A0.9770.70
409_R413_R0.9760.70
40_K45_L0.9750.70
192_R246_Q0.9730.70
276_F282_Q0.9720.70
87_G276_F0.9690.70
276_F285_F0.9580.69
149_V154_V0.9540.69
104_L326_V0.9510.68
259_M266_L0.9490.68
411_M419_N0.9480.68
246_Q250_D0.9450.68
236_V302_I0.9450.68
54_L80_A0.9400.68
168_M297_T0.9350.67
34_V457_R0.9330.67
377_V390_M0.9320.67
197_L301_L0.9300.67
119_A435_V0.9300.67
228_H231_Q0.9300.67
150_L153_G0.9280.66
262_Y280_E0.9270.66
424_V428_T0.9220.66
104_L235_M0.9210.66
56_G90_S0.9200.66
127_R309_S0.9200.66
131_S480_T0.9160.65
146_L149_V0.9140.65
247_V288_M0.9130.65
397_R401_F0.9090.65
128_N312_R0.9080.65
251_Y283_D0.9070.65
70_G95_G0.9060.65
51_V73_F0.9040.64
294_F380_P0.9000.64
248_A270_E0.8950.64
131_S302_I0.8910.63
327_Y376_I0.8850.63
447_E452_Y0.8830.63
181_D286_H0.8790.62
337_E350_V0.8770.62
147_D154_V0.8760.62
260_K269_R0.8720.62
167_D293_N0.8700.61
74_P351_H0.8690.61
104_L474_L0.8630.61
147_D151_A0.8600.61
141_L445_A0.8590.60
301_L305_W0.8570.60
45_L389_V0.8560.60
235_M387_S0.8510.60
122_V126_H0.8500.60
277_E281_G0.8460.59
134_G242_G0.8450.59
310_F314_F0.8380.59
310_F323_L0.8380.59
42_D69_Q0.8330.58
384_G449_P0.8310.58
339_Y400_W0.8290.58
455_V459_A0.8280.58
320_K323_L0.8270.58
89_V349_L0.8240.57
99_N292_A0.8210.57
155_A168_M0.8150.56
186_S189_A0.8130.56
210_Q351_H0.8050.55
264_I275_P0.8050.55
64_L77_G0.8020.55
99_N238_T0.8020.55
447_E481_K0.8010.55
240_S244_G0.8000.55
243_L247_V0.7990.55
62_Y455_V0.7990.55
40_K380_P0.7960.55
427_E460_K0.7940.54
285_F336_I0.7930.54
39_M410_W0.7900.54
393_I468_A0.7890.54
264_I273_A0.7880.54
96_Y245_H0.7870.54
79_A93_G0.7860.54
238_T382_S0.7810.53
248_A349_L0.7810.53
81_T88_V0.7790.53
96_Y272_A0.7780.53
423_N428_T0.7770.53
304_H308_E0.7770.53
388_Y468_A0.7750.53
121_L310_F0.7730.52
78_I93_G0.7720.52
91_P380_P0.7720.52
285_F349_L0.7690.52
167_D172_E0.7630.52
206_F235_M0.7620.51
424_V427_E0.7600.51
109_L232_V0.7580.51
189_A192_R0.7560.51
260_K263_N0.7530.51
75_I93_G0.7510.50
73_F77_G0.7510.50
171_M199_T0.7510.50
115_K415_A0.7480.50
423_N427_E0.7480.50
112_K229_E0.7480.50
373_I393_I0.7470.50
339_Y348_V0.7460.50
125_L209_I0.7450.50
124_E128_N0.7430.50
459_A468_A0.7430.50
373_I391_A0.7400.49
129_V399_T0.7390.49
96_Y249_S0.7370.49
251_Y291_G0.7360.49
134_G202_A0.7340.49
136_E195_S0.7330.49
424_V448_A0.7310.48
67_G382_S0.7290.48
134_G196_Q0.7290.48
91_P294_F0.7290.48
51_V81_T0.7280.48
68_H95_G0.7270.48
263_N275_P0.7260.48
56_G87_G0.7240.48
166_E324_S0.7230.48
94_I295_A0.7220.48
52_A61_I0.7210.48
89_V308_E0.7180.47
67_G294_F0.7180.47
209_I306_T0.7180.47
272_A306_T0.7160.47
131_S196_Q0.7140.47
386_A455_V0.7130.47
261_K285_F0.7120.47
126_H480_T0.7090.46
243_L290_S0.7080.46
303_T325_I0.7040.46
65_P97_D0.7040.46
142_T150_L0.7030.46
149_V297_T0.7030.46
438_A444_V0.7020.46
230_G308_E0.6970.45
404_P464_E0.6960.45
44_T69_Q0.6950.45
393_I397_R0.6930.45
404_P459_A0.6930.45
422_A426_V0.6920.45
426_V444_V0.6910.45
307_R314_F0.6900.45
121_L147_D0.6880.44
209_I234_V0.6880.44
252_L399_T0.6860.44
154_V297_T0.6850.44
447_E453_K0.6830.44
187_P191_Q0.6810.44
165_K169_N0.6810.44
46_R50_N0.6790.44
445_A450_G0.6780.44
210_Q384_G0.6770.43
128_N308_E0.6760.43
189_A246_Q0.6760.43
67_G194_A0.6740.43
153_G156_W0.6710.43
189_A250_D0.6680.43
77_G351_H0.6660.42
235_M380_P0.6660.42
72_G271_L0.6650.42
251_Y280_E0.6640.42
334_A349_L0.6640.42
106_R475_R0.6630.42
333_I380_P0.6620.42
302_I306_T0.6610.42
247_V290_S0.6590.42
241_R284_Y0.6590.42
266_L273_A0.6550.41
185_V189_A0.6550.41
96_Y270_E0.6540.41
133_V136_E0.6530.41
45_L414_E0.6530.41
70_G76_G0.6510.41
206_F333_I0.6510.41
80_A357_R0.6510.41
41_Q294_F0.6460.41
253_Q256_E0.6410.40
351_H436_V0.6360.40
54_L72_G0.6360.40
101_G200_L0.6350.40
73_F271_L0.6350.40
107_T232_V0.6350.40
421_P445_A0.6330.39
92_G245_H0.6330.39
315_G320_K0.6300.39
89_V323_L0.6300.39
303_T307_R0.6300.39
210_Q385_T0.6300.39
60_S400_W0.6290.39
114_V127_R0.6280.39
152_E417_V0.6260.39
231_Q389_V0.6210.38
124_E308_E0.6200.38
235_M384_G0.6200.38
120_Q123_E0.6190.38
91_P291_G0.6190.38
452_Y481_K0.6190.38
58_Q86_G0.6180.38
311_G321_L0.6180.38
40_K206_F0.6180.38
292_A479_V0.6170.38
186_S250_D0.6160.38
199_T279_R0.6160.38
248_A251_Y0.6160.38
381_G384_G0.6160.38
114_V311_G0.6140.38
308_E397_R0.6140.38
429_L436_V0.6140.38
283_D286_H0.6130.38
254_I257_R0.6120.37
126_H302_I0.6110.37
170_H286_H0.6100.37
351_H356_T0.6090.37
193_G479_V0.6080.37
404_P456_D0.6080.37
307_R310_F0.6070.37
307_R311_G0.6060.37
130_P271_L0.6060.37
299_R477_I0.6060.37
89_V199_T0.6060.37
42_D151_A0.6060.37
166_E199_T0.6020.37
155_A279_R0.6000.36
114_V480_T0.6000.36
53_C57_V0.5960.36
253_Q419_N0.5950.36
63_V305_W0.5950.36
44_T48_A0.5940.36
46_R49_T0.5930.36
154_V157_A0.5930.36
262_Y279_R0.5920.36
384_G407_A0.5920.36
141_L145_Q0.5910.36
61_I71_Y0.5910.36
258_A264_I0.5910.36
257_R427_E0.5900.36
78_I458_V0.5890.35
434_I479_V0.5880.35
280_E283_D0.5880.35
130_P200_L0.5880.35
453_K481_K0.5870.35
131_S202_A0.5860.35
378_L400_W0.5860.35
253_Q257_R0.5860.35
154_V158_V0.5840.35
74_P356_T0.5830.35
123_E324_S0.5820.35
189_A193_G0.5820.35
91_P255_M0.5820.35
260_K265_Q0.5800.35
56_G275_P0.5800.35
100_C204_N0.5800.35
152_E414_E0.5790.35
190_K243_L0.5780.35
122_V437_R0.5780.35
61_I93_G0.5780.35
46_R138_K0.5770.34
99_N335_K0.5730.34
330_A333_I0.5720.34
264_I346_K0.5720.34
112_K312_R0.5700.34
193_G334_A0.5670.34
103_R303_T0.5670.34
78_I355_A0.5660.34
210_Q386_A0.5650.33
146_L153_G0.5650.33
73_F446_E0.5640.33
209_I232_V0.5640.33
296_W300_Q0.5630.33
281_G303_T0.5630.33
75_I255_M0.5620.33
256_E260_K0.5610.33
148_Q257_R0.5590.33
329_V333_I0.5580.33
148_Q423_N0.5570.33
186_S246_Q0.5570.33
186_S193_G0.5560.33
47_Q70_G0.5560.33
276_F336_I0.5560.33
89_V372_N0.5550.33
381_G388_Y0.5540.32
447_E451_A0.5540.32
313_V372_N0.5540.32
99_N399_T0.5530.32
135_S460_K0.5520.32
281_G356_T0.5520.32
97_D353_K0.5520.32
442_R454_D0.5520.32
114_V478_G0.5510.32
34_V39_M0.5510.32
96_Y446_E0.5500.32
182_P186_S0.5500.32
200_L299_R0.5490.32
141_L149_V0.5490.32
443_V448_A0.5470.32
411_M415_A0.5470.32
113_D232_V0.5460.32
181_D184_K0.5460.32
210_Q476_P0.5460.32
196_Q412_S0.5460.32
146_L382_S0.5450.32
228_H233_M0.5450.32
168_M472_M0.5440.32
429_L438_A0.5440.32
456_D459_A0.5420.32
461_V467_I0.5400.31
62_Y99_N0.5390.31
99_N104_L0.5380.31
57_V78_I0.5370.31
206_F479_V0.5360.31
89_V391_A0.5360.31
255_M272_A0.5350.31
260_K308_E0.5340.31
413_R447_E0.5340.31
236_V285_F0.5330.31
409_R447_E0.5330.31
420_Y443_V0.5320.31
291_G343_G0.5320.31
236_V303_T0.5320.31
261_K279_R0.5300.31
339_Y401_F0.5300.31
129_V207_L0.5300.31
206_F248_A0.5290.30
429_L446_E0.5290.30
121_L229_E0.5290.30
147_D182_P0.5280.30
353_K409_R0.5280.30
435_V480_T0.5270.30
259_M262_Y0.5270.30
144_Q150_L0.5270.30
145_Q149_V0.5270.30
148_Q152_E0.5260.30
429_L448_A0.5260.30
254_I258_A0.5260.30
374_G391_A0.5260.30
91_P259_M0.5250.30
165_K434_I0.5250.30
67_G398_R0.5240.30
254_I419_N0.5220.30
170_H460_K0.5220.30
109_L231_Q0.5210.30
414_E417_V0.5200.30
209_I427_E0.5190.30
296_W333_I0.5190.30
69_Q270_E0.5180.30
354_G409_R0.5180.30
111_Y415_A0.5180.30
309_S313_V0.5180.30
289_A296_W0.5170.29
269_R465_V0.5160.29
63_V71_Y0.5160.29
63_V270_E0.5150.29
80_A193_G0.5150.29
238_T303_T0.5150.29
386_A429_L0.5140.29
248_A445_A0.5130.29
210_Q382_S0.5130.29
127_R138_K0.5110.29
63_V102_V0.5110.29
343_G411_M0.5110.29
149_V152_E0.5100.29
248_A380_P0.5100.29
49_T52_A0.5100.29
433_G475_R0.5080.29
353_K447_E0.5080.29
122_V292_A0.5080.29
109_L314_F0.5070.29
111_Y232_V0.5060.29
412_S420_Y0.5060.29
386_A479_V0.5060.29
457_R461_V0.5050.29
197_L246_Q0.5050.29
332_N353_K0.5040.28
286_H290_S0.5040.28
209_I422_A0.5040.28
281_G351_H0.5040.28
118_L480_T0.5030.28
71_Y96_Y0.5030.28
271_L337_E0.5020.28
134_G137_G0.5020.28
349_L479_V0.5020.28
241_R353_K0.5010.28
294_F403_A0.5010.28
407_A455_V0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4dwrB 3 0.9917 100 0.054 Contact Map
2epgA 1 0.9108 100 0.079 Contact Map
3b47A 2 0.2427 61.9 0.977 Contact Map
3b42A 2 0.2552 51.8 0.978 Contact Map
1pbyA 1 0.168 32.6 0.981 Contact Map
4mk6A 2 0.1515 22.9 0.982 Contact Map
4x90A 4 0.2012 15.3 0.983 Contact Map
3vseA 1 0.2697 15 0.984 Contact Map
3m92A 2 0.0954 13.2 0.984 Contact Map
1w2lA 1 0.168 10.5 0.985 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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