GREMLIN Database
DHYS - Probable deoxyhypusine synthase
UniProt: Q97ZF1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 312 (298)
Sequences: 804 (440)
Seq/√Len: 25.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
297_G302_I6.9381.00
67_V177_I6.3581.00
169_K182_Y6.1311.00
61_S246_T4.7631.00
51_M233_G3.6341.00
165_W182_Y3.6321.00
150_E170_R3.5871.00
192_G241_I3.3261.00
297_G301_I3.2861.00
237_I303_V3.1201.00
237_I299_A3.0011.00
113_I130_L2.9761.00
178_L188_I2.9701.00
98_L178_L2.9371.00
262_I302_I2.9051.00
79_I181_A2.8491.00
50_E291_K2.8271.00
57_L225_L2.7931.00
165_W185_N2.7560.99
193_I215_L2.6770.99
44_G295_I2.6310.99
203_F227_F2.6290.99
76_A80_K2.5920.99
179_R183_D2.4390.99
232_S250_N2.4190.99
235_L306_L2.4050.98
189_I221_L2.2570.98
78_L307_A2.2310.97
18_S80_K2.2290.97
134_E138_K2.0680.96
79_I84_F2.0450.96
79_I87_V2.0330.96
75_F177_I1.9670.95
80_K174_S1.9460.94
163_L213_I1.9400.94
15_I23_Y1.9370.94
162_E217_E1.9070.94
123_I130_L1.8420.93
153_K157_E1.8150.92
22_K25_D1.8080.92
159_S217_E1.7850.91
41_I306_L1.7510.91
124_H133_F1.7140.90
47_I50_E1.7080.89
41_I45_S1.6910.89
262_I297_G1.6780.89
45_S309_S1.6720.88
235_L303_V1.6490.88
202_L216_F1.6400.87
150_E153_K1.6080.86
15_I22_K1.5830.85
279_E285_K1.5760.85
148_L202_L1.5650.85
120_D288_P1.5580.84
82_G184_K1.5290.83
31_D46_K1.5120.83
189_I225_L1.5010.82
109_G130_L1.4800.81
40_G43_N1.4790.81
242_S273_S1.4740.81
212_R217_E1.4670.81
258_Y298_D1.4610.80
151_I163_L1.4530.80
60_L84_F1.4270.79
41_I301_I1.4170.78
85_N232_S1.3710.76
68_S96_H1.3690.76
80_K183_D1.3670.76
48_L235_L1.3620.75
161_Y221_L1.3600.75
30_F301_I1.3550.75
47_I292_H1.3280.73
166_E170_R1.3200.73
37_S40_G1.3110.72
66_L69_T1.3020.72
13_E32_K1.2930.71
88_V246_T1.2790.71
27_V305_I1.2680.70
234_A256_L1.2670.70
152_T211_F1.2660.70
295_I302_I1.2640.70
180_A184_K1.2450.68
43_N291_K1.2380.68
279_E283_W1.2350.68
234_A247_I1.2300.67
224_D228_S1.2100.66
102_F167_F1.2070.66
68_S126_L1.1730.64
38_S305_I1.1680.63
86_I225_L1.1660.63
114_D117_M1.1660.63
15_I34_Y1.1650.63
166_E169_K1.1580.63
169_K183_D1.1550.62
163_L202_L1.1540.62
149_P205_Q1.1470.62
164_L178_L1.1400.61
48_L306_L1.1320.61
190_V213_I1.1290.61
165_W169_K1.1170.60
75_F291_K1.1160.60
207_Q210_N1.1110.59
71_L300_T1.1090.59
77_D81_K1.1080.59
57_L232_S1.0950.58
78_L235_L1.0940.58
52_I83_Y1.0920.58
12_V108_K1.0910.58
91_G196_G1.0900.58
282_S285_K1.0870.58
41_I295_I1.0820.57
26_I80_K1.0810.57
103_G242_S1.0730.57
99_A140_I1.0640.56
15_I20_L1.0620.56
90_T192_G1.0600.56
59_F246_T1.0570.56
26_I308_A1.0450.55
109_G123_I1.0430.55
66_L71_L1.0420.54
216_F219_M1.0420.54
180_A183_D1.0390.54
17_L23_Y1.0290.53
202_L213_I1.0160.53
55_A231_K1.0160.53
216_F237_I1.0150.52
140_I197_S1.0010.51
20_L25_D0.9950.51
92_G128_N0.9890.51
63_T277_P0.9840.50
264_T269_D0.9820.50
61_S192_G0.9740.49
50_E150_E0.9680.49
119_K149_P0.9630.49
13_E175_N0.9590.48
31_D42_V0.9560.48
53_K185_N0.9530.48
23_Y26_I0.9530.48
277_P294_T0.9400.47
38_S98_L0.9320.46
177_I181_A0.9300.46
274_G279_E0.9280.46
64_A69_T0.9270.46
277_P286_I0.9270.46
244_H248_W0.9190.45
39_E64_A0.9170.45
82_G186_V0.9110.45
37_S65_N0.9090.45
270_G285_K0.9070.45
28_S309_S0.9030.44
295_I299_A0.9020.44
44_G260_I0.9020.44
40_G296_Y0.8980.44
127_G244_H0.8980.44
255_G287_R0.8970.44
275_A279_E0.8960.44
47_I293_V0.8950.44
35_G69_T0.8930.44
46_K49_K0.8910.43
20_L26_I0.8900.43
66_L102_F0.8840.43
28_S46_K0.8800.43
137_G201_N0.8750.42
150_E169_K0.8620.41
96_H248_W0.8550.41
27_V308_A0.8520.41
18_S81_K0.8510.41
153_K208_F0.8460.40
46_K50_E0.8450.40
279_E282_S0.8430.40
92_G196_G0.8410.40
70_G97_D0.8400.40
41_I102_F0.8390.40
117_M121_L0.8380.40
67_V237_I0.8380.40
123_I281_I0.8380.40
24_N308_A0.8370.40
274_G285_K0.8320.39
136_Y141_E0.8310.39
50_E53_K0.8300.39
79_I186_V0.8280.39
57_L85_N0.8280.39
57_L229_S0.8280.39
154_D166_E0.8260.39
17_L123_I0.8250.39
23_Y306_L0.8220.39
197_S201_N0.8190.38
20_L23_Y0.8180.38
150_E157_E0.8130.38
151_I158_I0.8110.38
267_E274_G0.8110.38
99_A192_G0.8100.38
244_H271_S0.8080.38
159_S222_I0.8080.38
298_D301_I0.8060.37
245_H250_N0.8060.37
177_I188_I0.8040.37
40_G298_D0.8020.37
48_L295_I0.8010.37
123_I159_S0.7970.37
275_A285_K0.7970.37
237_I262_I0.7950.37
30_F34_Y0.7930.37
50_E54_N0.7910.36
288_P306_L0.7830.36
265_A269_D0.7830.36
49_K53_K0.7830.36
242_S298_D0.7810.36
270_G283_W0.7800.36
117_M288_P0.7760.35
56_D258_Y0.7740.35
92_G127_G0.7670.35
22_K229_S0.7640.35
70_G243_K0.7630.35
45_S57_L0.7570.34
96_H272_L0.7550.34
119_K254_D0.7500.34
84_F87_V0.7490.34
25_D301_I0.7480.34
116_T190_V0.7480.34
102_F193_I0.7460.33
35_G128_N0.7440.33
167_F171_I0.7430.33
24_N309_S0.7430.33
244_H276_K0.7420.33
30_F153_K0.7420.33
288_P298_D0.7400.33
163_L228_S0.7400.33
76_A180_A0.7390.33
223_K251_Q0.7370.33
57_L233_G0.7350.33
57_L86_I0.7350.33
13_E19_D0.7350.33
124_H137_G0.7350.33
192_G246_T0.7350.33
178_L182_Y0.7320.33
86_I250_N0.7310.32
110_S130_L0.7300.32
18_S54_N0.7290.32
239_G273_S0.7280.32
97_D176_S0.7260.32
14_D73_G0.7250.32
22_K301_I0.7240.32
71_L75_F0.7230.32
99_A137_G0.7210.32
36_F189_I0.7200.32
29_V32_K0.7200.32
68_S197_S0.7190.32
23_Y27_V0.7140.31
64_A100_R0.7140.31
69_T100_R0.7110.31
144_V163_L0.7110.31
219_M224_D0.7090.31
177_I274_G0.7080.31
36_F107_Y0.7060.31
244_H255_G0.7060.31
251_Q278_R0.7060.31
62_F271_S0.7040.31
95_D249_W0.7020.31
140_I144_V0.7010.31
142_D146_K0.7010.31
66_L252_F0.7010.31
92_G245_H0.7010.31
68_S95_D0.7000.31
179_R184_K0.6980.30
119_K122_E0.6960.30
68_S248_W0.6940.30
145_R148_L0.6940.30
21_K163_L0.6930.30
35_G72_R0.6900.30
65_N68_S0.6860.30
163_L216_F0.6860.30
100_R124_H0.6850.30
236_I286_I0.6800.29
93_T298_D0.6790.29
19_D31_D0.6790.29
144_V198_F0.6760.29
116_T120_D0.6750.29
174_S262_I0.6750.29
182_Y193_I0.6740.29
95_D248_W0.6720.29
98_L298_D0.6720.29
148_L213_I0.6700.29
303_V307_A0.6670.28
41_I48_L0.6660.28
105_V129_V0.6650.28
69_T91_G0.6630.28
74_L231_K0.6600.28
64_A96_H0.6600.28
273_S298_D0.6590.28
101_S186_V0.6590.28
31_D43_N0.6580.28
226_I250_N0.6580.28
18_S76_A0.6530.28
48_L52_I0.6510.28
242_S265_A0.6510.28
141_E251_Q0.6500.27
110_S113_I0.6480.27
222_I266_Q0.6470.27
95_D99_A0.6470.27
239_G279_E0.6450.27
159_S287_R0.6440.27
245_H265_A0.6440.27
82_G174_S0.6430.27
48_L260_I0.6430.27
242_S296_Y0.6430.27
280_A283_W0.6380.27
64_A93_T0.6360.27
280_A285_K0.6350.27
144_V148_L0.6350.27
110_S134_E0.6330.27
98_L188_I0.6310.26
156_K162_E0.6290.26
152_T205_Q0.6290.26
44_G214_N0.6290.26
159_S167_F0.6280.26
272_L294_T0.6280.26
58_R84_F0.6250.26
65_N248_W0.6240.26
274_G282_S0.6230.26
114_D150_E0.6220.26
11_P19_D0.6200.26
219_M223_K0.6180.26
97_D284_N0.6170.26
95_D251_Q0.6170.26
217_E221_L0.6170.26
96_H200_T0.6160.26
275_A283_W0.6160.26
225_L228_S0.6160.26
247_I309_S0.6150.25
295_I306_L0.6140.25
145_R296_Y0.6110.25
65_N92_G0.6080.25
63_T130_L0.6080.25
276_K296_Y0.6070.25
98_L181_A0.6070.25
79_I180_A0.6050.25
173_D176_S0.6050.25
59_F226_I0.6050.25
37_S72_R0.6040.25
92_G100_R0.6030.25
286_I293_V0.6030.25
54_N230_K0.6020.25
87_V233_G0.6010.25
116_T281_I0.6000.25
95_D200_T0.6000.25
19_D25_D0.5990.25
23_Y41_I0.5970.25
75_F87_V0.5950.24
62_F273_S0.5920.24
61_S88_V0.5900.24
234_A246_T0.5890.24
43_N50_E0.5860.24
31_D309_S0.5860.24
13_E185_N0.5850.24
188_I259_A0.5850.24
11_P18_S0.5840.24
124_H251_Q0.5830.24
96_H136_Y0.5820.24
45_S306_L0.5820.24
98_L158_I0.5800.24
12_V84_F0.5770.23
127_G271_S0.5760.23
14_D17_L0.5750.23
115_D278_R0.5750.23
172_T185_N0.5740.23
19_D120_D0.5740.23
145_R159_S0.5720.23
163_L193_I0.5710.23
64_A92_G0.5690.23
150_E166_E0.5680.23
11_P144_V0.5680.23
242_S245_H0.5650.23
257_N287_R0.5640.23
173_D178_L0.5640.23
146_K210_N0.5630.23
221_L260_I0.5580.22
136_Y244_H0.5560.22
54_N75_F0.5550.22
72_R196_G0.5550.22
19_D50_E0.5550.22
167_F198_F0.5540.22
78_L83_Y0.5530.22
48_L305_I0.5520.22
63_T261_Y0.5510.22
245_H267_E0.5490.22
34_Y273_S0.5490.22
206_S210_N0.5490.22
99_A141_E0.5490.22
22_K297_G0.5480.22
183_D186_V0.5460.22
63_T92_G0.5460.22
44_G296_Y0.5450.22
74_L181_A0.5450.22
137_G142_D0.5440.22
38_S257_N0.5440.22
169_K202_L0.5440.22
281_I286_I0.5430.22
90_T265_A0.5420.22
152_T210_N0.5420.22
143_V149_P0.5400.22
37_S64_A0.5400.22
59_F250_N0.5400.22
245_H252_F0.5400.22
29_V300_T0.5390.22
31_D58_R0.5380.21
247_I256_L0.5370.21
120_D162_E0.5350.21
128_N196_G0.5340.21
43_N87_V0.5320.21
244_H250_N0.5310.21
162_E221_L0.5310.21
95_D197_S0.5300.21
80_K180_A0.5280.21
146_K149_P0.5280.21
161_Y165_W0.5270.21
140_I251_Q0.5270.21
76_A166_E0.5270.21
174_S183_D0.5260.21
208_F212_R0.5260.21
62_F265_A0.5240.21
274_G283_W0.5240.21
84_F178_L0.5220.21
92_G244_H0.5210.21
263_T272_L0.5190.21
90_T229_S0.5160.20
93_T245_H0.5160.20
57_L66_L0.5160.20
145_R201_N0.5150.20
24_N153_K0.5150.20
142_D198_F0.5130.20
87_V241_I0.5130.20
47_I262_I0.5120.20
42_V189_I0.5120.20
27_V301_I0.5110.20
239_G285_K0.5090.20
205_Q220_R0.5070.20
37_S267_E0.5070.20
15_I30_F0.5050.20
236_I293_V0.5050.20
177_I273_S0.5040.20
52_I56_D0.5030.20
47_I233_G0.5030.20
80_K212_R0.5010.20
32_K297_G0.5010.20
203_F224_D0.5000.20
141_E201_N0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4p63A 4 0.9519 100 0.04 Contact Map
1rlzA 4 0.9904 100 0.05 Contact Map
3c2qA 4 0.8173 93.4 0.95 Contact Map
1y80A 1 0.3622 26.7 0.972 Contact Map
2q5cA 2 0.3814 22.6 0.973 Contact Map
2m6rA 1 0.4231 20.9 0.974 Contact Map
2ixdA 5 0.6603 19.3 0.974 Contact Map
2y3sA 2 0.5096 18.9 0.974 Contact Map
1ko7A 3 0.6571 17.4 0.975 Contact Map
1dekA 2 0.625 15.9 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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