DHYS - SULSO - GREMLIN Contacts

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DHYS - Probable deoxyhypusine synthase

UniProt:	Q97ZF1	Sequences: MINREDLLKNPVEDITLSDLKKYNDIVSVFDKIYGFSSEGIVNGSKILKEMIKNADLRFLSFTANLVSTGLRGLFADLIKKGYFNIVVTTGGTIDHDLARSFGGVYYKGSFDIDDTMLKDLEIHRLGNVLVPFESYGKVIEDVVRKFLPEITKDRKEISAYELLWEFGKRITDSNSILRAAYDKNVPIIVPGILDGSFGTNLFIQSQFLNFRINLFEDMRLIKDLIFSSKKSGALIIGGGISKHHTIWWNQFKDGLNYAIYITTAQEYDGSLSGAKPREAISWNKIRPDAKHVTIYGDATIIVPILAASLLS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	312 (298)
Sequences:	804 (440)
Seq/√Len:	25.5

HALSA - DHYS
SULSO - DHYS

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
297_G	302_I	6.938	1.00
67_V	177_I	6.358	1.00
169_K	182_Y	6.131	1.00
61_S	246_T	4.763	1.00
51_M	233_G	3.634	1.00
165_W	182_Y	3.632	1.00
150_E	170_R	3.587	1.00
192_G	241_I	3.326	1.00
297_G	301_I	3.286	1.00
237_I	303_V	3.120	1.00
237_I	299_A	3.001	1.00
113_I	130_L	2.976	1.00
178_L	188_I	2.970	1.00
98_L	178_L	2.937	1.00
262_I	302_I	2.905	1.00
79_I	181_A	2.849	1.00
50_E	291_K	2.827	1.00
57_L	225_L	2.793	1.00
165_W	185_N	2.756	0.99
193_I	215_L	2.677	0.99
44_G	295_I	2.631	0.99
203_F	227_F	2.629	0.99
76_A	80_K	2.592	0.99
179_R	183_D	2.439	0.99
232_S	250_N	2.419	0.99
235_L	306_L	2.405	0.98
189_I	221_L	2.257	0.98
78_L	307_A	2.231	0.97
18_S	80_K	2.229	0.97
134_E	138_K	2.068	0.96
79_I	84_F	2.045	0.96
79_I	87_V	2.033	0.96
75_F	177_I	1.967	0.95
80_K	174_S	1.946	0.94
163_L	213_I	1.940	0.94
15_I	23_Y	1.937	0.94
162_E	217_E	1.907	0.94
123_I	130_L	1.842	0.93
153_K	157_E	1.815	0.92
22_K	25_D	1.808	0.92
159_S	217_E	1.785	0.91
41_I	306_L	1.751	0.91
124_H	133_F	1.714	0.90
47_I	50_E	1.708	0.89
41_I	45_S	1.691	0.89
262_I	297_G	1.678	0.89
45_S	309_S	1.672	0.88
235_L	303_V	1.649	0.88
202_L	216_F	1.640	0.87
150_E	153_K	1.608	0.86
15_I	22_K	1.583	0.85
279_E	285_K	1.576	0.85
148_L	202_L	1.565	0.85
120_D	288_P	1.558	0.84
82_G	184_K	1.529	0.83
31_D	46_K	1.512	0.83
189_I	225_L	1.501	0.82
109_G	130_L	1.480	0.81
40_G	43_N	1.479	0.81
242_S	273_S	1.474	0.81
212_R	217_E	1.467	0.81
258_Y	298_D	1.461	0.80
151_I	163_L	1.453	0.80
60_L	84_F	1.427	0.79
41_I	301_I	1.417	0.78
85_N	232_S	1.371	0.76
68_S	96_H	1.369	0.76
80_K	183_D	1.367	0.76
48_L	235_L	1.362	0.75
161_Y	221_L	1.360	0.75
30_F	301_I	1.355	0.75
47_I	292_H	1.328	0.73
166_E	170_R	1.320	0.73
37_S	40_G	1.311	0.72
66_L	69_T	1.302	0.72
13_E	32_K	1.293	0.71
88_V	246_T	1.279	0.71
27_V	305_I	1.268	0.70
234_A	256_L	1.267	0.70
152_T	211_F	1.266	0.70
295_I	302_I	1.264	0.70
180_A	184_K	1.245	0.68
43_N	291_K	1.238	0.68
279_E	283_W	1.235	0.68
234_A	247_I	1.230	0.67
224_D	228_S	1.210	0.66
102_F	167_F	1.207	0.66
68_S	126_L	1.173	0.64
38_S	305_I	1.168	0.63
86_I	225_L	1.166	0.63
114_D	117_M	1.166	0.63
15_I	34_Y	1.165	0.63
166_E	169_K	1.158	0.63
169_K	183_D	1.155	0.62
163_L	202_L	1.154	0.62
149_P	205_Q	1.147	0.62
164_L	178_L	1.140	0.61
48_L	306_L	1.132	0.61
190_V	213_I	1.129	0.61
165_W	169_K	1.117	0.60
75_F	291_K	1.116	0.60
207_Q	210_N	1.111	0.59
71_L	300_T	1.109	0.59
77_D	81_K	1.108	0.59
57_L	232_S	1.095	0.58
78_L	235_L	1.094	0.58
52_I	83_Y	1.092	0.58
12_V	108_K	1.091	0.58
91_G	196_G	1.090	0.58
282_S	285_K	1.087	0.58
41_I	295_I	1.082	0.57
26_I	80_K	1.081	0.57
103_G	242_S	1.073	0.57
99_A	140_I	1.064	0.56
15_I	20_L	1.062	0.56
90_T	192_G	1.060	0.56
59_F	246_T	1.057	0.56
26_I	308_A	1.045	0.55
109_G	123_I	1.043	0.55
66_L	71_L	1.042	0.54
216_F	219_M	1.042	0.54
180_A	183_D	1.039	0.54
17_L	23_Y	1.029	0.53
202_L	213_I	1.016	0.53
55_A	231_K	1.016	0.53
216_F	237_I	1.015	0.52
140_I	197_S	1.001	0.51
20_L	25_D	0.995	0.51
92_G	128_N	0.989	0.51
63_T	277_P	0.984	0.50
264_T	269_D	0.982	0.50
61_S	192_G	0.974	0.49
50_E	150_E	0.968	0.49
119_K	149_P	0.963	0.49
13_E	175_N	0.959	0.48
31_D	42_V	0.956	0.48
53_K	185_N	0.953	0.48
23_Y	26_I	0.953	0.48
277_P	294_T	0.940	0.47
38_S	98_L	0.932	0.46
177_I	181_A	0.930	0.46
274_G	279_E	0.928	0.46
64_A	69_T	0.927	0.46
277_P	286_I	0.927	0.46
244_H	248_W	0.919	0.45
39_E	64_A	0.917	0.45
82_G	186_V	0.911	0.45
37_S	65_N	0.909	0.45
270_G	285_K	0.907	0.45
28_S	309_S	0.903	0.44
295_I	299_A	0.902	0.44
44_G	260_I	0.902	0.44
40_G	296_Y	0.898	0.44
127_G	244_H	0.898	0.44
255_G	287_R	0.897	0.44
275_A	279_E	0.896	0.44
47_I	293_V	0.895	0.44
35_G	69_T	0.893	0.44
46_K	49_K	0.891	0.43
20_L	26_I	0.890	0.43
66_L	102_F	0.884	0.43
28_S	46_K	0.880	0.43
137_G	201_N	0.875	0.42
150_E	169_K	0.862	0.41
96_H	248_W	0.855	0.41
27_V	308_A	0.852	0.41
18_S	81_K	0.851	0.41
153_K	208_F	0.846	0.40
46_K	50_E	0.845	0.40
279_E	282_S	0.843	0.40
92_G	196_G	0.841	0.40
70_G	97_D	0.840	0.40
41_I	102_F	0.839	0.40
117_M	121_L	0.838	0.40
67_V	237_I	0.838	0.40
123_I	281_I	0.838	0.40
24_N	308_A	0.837	0.40
274_G	285_K	0.832	0.39
136_Y	141_E	0.831	0.39
50_E	53_K	0.830	0.39
79_I	186_V	0.828	0.39
57_L	85_N	0.828	0.39
57_L	229_S	0.828	0.39
154_D	166_E	0.826	0.39
17_L	123_I	0.825	0.39
23_Y	306_L	0.822	0.39
197_S	201_N	0.819	0.38
20_L	23_Y	0.818	0.38
150_E	157_E	0.813	0.38
151_I	158_I	0.811	0.38
267_E	274_G	0.811	0.38
99_A	192_G	0.810	0.38
244_H	271_S	0.808	0.38
159_S	222_I	0.808	0.38
298_D	301_I	0.806	0.37
245_H	250_N	0.806	0.37
177_I	188_I	0.804	0.37
40_G	298_D	0.802	0.37
48_L	295_I	0.801	0.37
123_I	159_S	0.797	0.37
275_A	285_K	0.797	0.37
237_I	262_I	0.795	0.37
30_F	34_Y	0.793	0.37
50_E	54_N	0.791	0.36
288_P	306_L	0.783	0.36
265_A	269_D	0.783	0.36
49_K	53_K	0.783	0.36
242_S	298_D	0.781	0.36
270_G	283_W	0.780	0.36
117_M	288_P	0.776	0.35
56_D	258_Y	0.774	0.35
92_G	127_G	0.767	0.35
22_K	229_S	0.764	0.35
70_G	243_K	0.763	0.35
45_S	57_L	0.757	0.34
96_H	272_L	0.755	0.34
119_K	254_D	0.750	0.34
84_F	87_V	0.749	0.34
25_D	301_I	0.748	0.34
116_T	190_V	0.748	0.34
102_F	193_I	0.746	0.33
35_G	128_N	0.744	0.33
167_F	171_I	0.743	0.33
24_N	309_S	0.743	0.33
244_H	276_K	0.742	0.33
30_F	153_K	0.742	0.33
288_P	298_D	0.740	0.33
163_L	228_S	0.740	0.33
76_A	180_A	0.739	0.33
223_K	251_Q	0.737	0.33
57_L	233_G	0.735	0.33
57_L	86_I	0.735	0.33
13_E	19_D	0.735	0.33
124_H	137_G	0.735	0.33
192_G	246_T	0.735	0.33
178_L	182_Y	0.732	0.33
86_I	250_N	0.731	0.32
110_S	130_L	0.730	0.32
18_S	54_N	0.729	0.32
239_G	273_S	0.728	0.32
97_D	176_S	0.726	0.32
14_D	73_G	0.725	0.32
22_K	301_I	0.724	0.32
71_L	75_F	0.723	0.32
99_A	137_G	0.721	0.32
36_F	189_I	0.720	0.32
29_V	32_K	0.720	0.32
68_S	197_S	0.719	0.32
23_Y	27_V	0.714	0.31
64_A	100_R	0.714	0.31
69_T	100_R	0.711	0.31
144_V	163_L	0.711	0.31
219_M	224_D	0.709	0.31
177_I	274_G	0.708	0.31
36_F	107_Y	0.706	0.31
244_H	255_G	0.706	0.31
251_Q	278_R	0.706	0.31
62_F	271_S	0.704	0.31
95_D	249_W	0.702	0.31
140_I	144_V	0.701	0.31
142_D	146_K	0.701	0.31
66_L	252_F	0.701	0.31
92_G	245_H	0.701	0.31
68_S	95_D	0.700	0.31
179_R	184_K	0.698	0.30
119_K	122_E	0.696	0.30
68_S	248_W	0.694	0.30
145_R	148_L	0.694	0.30
21_K	163_L	0.693	0.30
35_G	72_R	0.690	0.30
65_N	68_S	0.686	0.30
163_L	216_F	0.686	0.30
100_R	124_H	0.685	0.30
236_I	286_I	0.680	0.29
93_T	298_D	0.679	0.29
19_D	31_D	0.679	0.29
144_V	198_F	0.676	0.29
116_T	120_D	0.675	0.29
174_S	262_I	0.675	0.29
182_Y	193_I	0.674	0.29
95_D	248_W	0.672	0.29
98_L	298_D	0.672	0.29
148_L	213_I	0.670	0.29
303_V	307_A	0.667	0.28
41_I	48_L	0.666	0.28
105_V	129_V	0.665	0.28
69_T	91_G	0.663	0.28
74_L	231_K	0.660	0.28
64_A	96_H	0.660	0.28
273_S	298_D	0.659	0.28
101_S	186_V	0.659	0.28
31_D	43_N	0.658	0.28
226_I	250_N	0.658	0.28
18_S	76_A	0.653	0.28
48_L	52_I	0.651	0.28
242_S	265_A	0.651	0.28
141_E	251_Q	0.650	0.27
110_S	113_I	0.648	0.27
222_I	266_Q	0.647	0.27
95_D	99_A	0.647	0.27
239_G	279_E	0.645	0.27
159_S	287_R	0.644	0.27
245_H	265_A	0.644	0.27
82_G	174_S	0.643	0.27
48_L	260_I	0.643	0.27
242_S	296_Y	0.643	0.27
280_A	283_W	0.638	0.27
64_A	93_T	0.636	0.27
280_A	285_K	0.635	0.27
144_V	148_L	0.635	0.27
110_S	134_E	0.633	0.27
98_L	188_I	0.631	0.26
156_K	162_E	0.629	0.26
152_T	205_Q	0.629	0.26
44_G	214_N	0.629	0.26
159_S	167_F	0.628	0.26
272_L	294_T	0.628	0.26
58_R	84_F	0.625	0.26
65_N	248_W	0.624	0.26
274_G	282_S	0.623	0.26
114_D	150_E	0.622	0.26
11_P	19_D	0.620	0.26
219_M	223_K	0.618	0.26
97_D	284_N	0.617	0.26
95_D	251_Q	0.617	0.26
217_E	221_L	0.617	0.26
96_H	200_T	0.616	0.26
275_A	283_W	0.616	0.26
225_L	228_S	0.616	0.26
247_I	309_S	0.615	0.25
295_I	306_L	0.614	0.25
145_R	296_Y	0.611	0.25
65_N	92_G	0.608	0.25
63_T	130_L	0.608	0.25
276_K	296_Y	0.607	0.25
98_L	181_A	0.607	0.25
79_I	180_A	0.605	0.25
173_D	176_S	0.605	0.25
59_F	226_I	0.605	0.25
37_S	72_R	0.604	0.25
92_G	100_R	0.603	0.25
286_I	293_V	0.603	0.25
54_N	230_K	0.602	0.25
87_V	233_G	0.601	0.25
116_T	281_I	0.600	0.25
95_D	200_T	0.600	0.25
19_D	25_D	0.599	0.25
23_Y	41_I	0.597	0.25
75_F	87_V	0.595	0.24
62_F	273_S	0.592	0.24
61_S	88_V	0.590	0.24
234_A	246_T	0.589	0.24
43_N	50_E	0.586	0.24
31_D	309_S	0.586	0.24
13_E	185_N	0.585	0.24
188_I	259_A	0.585	0.24
11_P	18_S	0.584	0.24
124_H	251_Q	0.583	0.24
96_H	136_Y	0.582	0.24
45_S	306_L	0.582	0.24
98_L	158_I	0.580	0.24
12_V	84_F	0.577	0.23
127_G	271_S	0.576	0.23
14_D	17_L	0.575	0.23
115_D	278_R	0.575	0.23
172_T	185_N	0.574	0.23
19_D	120_D	0.574	0.23
145_R	159_S	0.572	0.23
163_L	193_I	0.571	0.23
64_A	92_G	0.569	0.23
150_E	166_E	0.568	0.23
11_P	144_V	0.568	0.23
242_S	245_H	0.565	0.23
257_N	287_R	0.564	0.23
173_D	178_L	0.564	0.23
146_K	210_N	0.563	0.23
221_L	260_I	0.558	0.22
136_Y	244_H	0.556	0.22
54_N	75_F	0.555	0.22
72_R	196_G	0.555	0.22
19_D	50_E	0.555	0.22
167_F	198_F	0.554	0.22
78_L	83_Y	0.553	0.22
48_L	305_I	0.552	0.22
63_T	261_Y	0.551	0.22
245_H	267_E	0.549	0.22
34_Y	273_S	0.549	0.22
206_S	210_N	0.549	0.22
99_A	141_E	0.549	0.22
22_K	297_G	0.548	0.22
183_D	186_V	0.546	0.22
63_T	92_G	0.546	0.22
44_G	296_Y	0.545	0.22
74_L	181_A	0.545	0.22
137_G	142_D	0.544	0.22
38_S	257_N	0.544	0.22
169_K	202_L	0.544	0.22
281_I	286_I	0.543	0.22
90_T	265_A	0.542	0.22
152_T	210_N	0.542	0.22
143_V	149_P	0.540	0.22
37_S	64_A	0.540	0.22
59_F	250_N	0.540	0.22
245_H	252_F	0.540	0.22
29_V	300_T	0.539	0.22
31_D	58_R	0.538	0.21
247_I	256_L	0.537	0.21
120_D	162_E	0.535	0.21
128_N	196_G	0.534	0.21
43_N	87_V	0.532	0.21
244_H	250_N	0.531	0.21
162_E	221_L	0.531	0.21
95_D	197_S	0.530	0.21
80_K	180_A	0.528	0.21
146_K	149_P	0.528	0.21
161_Y	165_W	0.527	0.21
140_I	251_Q	0.527	0.21
76_A	166_E	0.527	0.21
174_S	183_D	0.526	0.21
208_F	212_R	0.526	0.21
62_F	265_A	0.524	0.21
274_G	283_W	0.524	0.21
84_F	178_L	0.522	0.21
92_G	244_H	0.521	0.21
263_T	272_L	0.519	0.21
90_T	229_S	0.516	0.20
93_T	245_H	0.516	0.20
57_L	66_L	0.516	0.20
145_R	201_N	0.515	0.20
24_N	153_K	0.515	0.20
142_D	198_F	0.513	0.20
87_V	241_I	0.513	0.20
47_I	262_I	0.512	0.20
42_V	189_I	0.512	0.20
27_V	301_I	0.511	0.20
239_G	285_K	0.509	0.20
205_Q	220_R	0.507	0.20
37_S	267_E	0.507	0.20
15_I	30_F	0.505	0.20
236_I	293_V	0.505	0.20
177_I	273_S	0.504	0.20
52_I	56_D	0.503	0.20
47_I	233_G	0.503	0.20
80_K	212_R	0.501	0.20
32_K	297_G	0.501	0.20
203_F	224_D	0.500	0.20
141_E	201_N	0.500	0.20

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4p63A	4	0.9519	100	0.04	Contact Map
1rlzA	4	0.9904	100	0.05	Contact Map
3c2qA	4	0.8173	93.4	0.95	Contact Map
1y80A	1	0.3622	26.7	0.972	Contact Map
2q5cA	2	0.3814	22.6	0.973	Contact Map
2m6rA	1	0.4231	20.9	0.974	Contact Map
2ixdA	5	0.6603	19.3	0.974	Contact Map
2y3sA	2	0.5096	18.9	0.974	Contact Map
1ko7A	3	0.6571	17.4	0.975	Contact Map
1dekA	2	0.625	15.9	0.975	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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