Q97ZE9 - SULSO - GREMLIN Contacts

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Q97ZE9 - Type 2 DNA topoisomerase 6 subunit A

UniProt:	Q97ZE9	Sequences: MSSEFISKVDKEARRKAASILRDKFLNLVEQLKKGEPLVMEIPMRTLSNAIYDEKRKLLLLGEKKLKRNFLDMNEAKRFMQTVLMASIIYDALVSDEYPTIRDLYYRGKHSLLLKSIDGNKIVSEENTWDEQKESDSVIVDIEVFTSLLREEMLILSKEKGKVVGNLRIRSGNDTIDLSKTGHGAYAIEPTPDLIDFIDVDAEFVLVVEKDAVFQQLHRAGFWKQYKSILITSAGQPDRATRRFVRRLNEELKLPVYILTDADPYGWYIFSVFRIGSISLSYESERLATPDAKFLGVSMSDIFGNSRKKPYLSEAERKNYIIKAKEADIKRAEEIKNYEWFKTKAWEEEINTFLHRKAKLEIEAMASKGLKFLAFQYIPEKITNKDYIA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	389 (346)
Sequences:	464 (302)
Seq/√Len:	16.2

HALSA - TOP6A
SULSO - Q97ZE9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
213_V	363_E	5.852	1.00
163_V	244_F	4.354	1.00
202_A	229_I	3.633	1.00
300_S	349_E	3.556	1.00
166_N	201_D	3.461	0.99
378_I	382_I	3.283	0.99
247_R	251_E	3.255	0.99
22_R	100_T	3.138	0.99
233_S	273_F	3.093	0.99
232_T	238_D	2.930	0.98
270_F	294_F	2.896	0.98
332_A	354_L	2.890	0.98
232_T	273_F	2.868	0.98
207_V	292_A	2.811	0.97
264_P	324_A	2.800	0.97
229_I	295_L	2.672	0.97
256_V	292_A	2.637	0.96
246_R	250_E	2.612	0.96
216_Q	220_A	2.561	0.96
233_S	238_D	2.545	0.95
330_K	334_E	2.493	0.95
268_Y	338_Y	2.478	0.95
362_I	373_L	2.436	0.94
132_Q	136_D	2.341	0.93
82_T	245_V	2.288	0.92
160_K	238_D	2.189	0.90
259_L	362_I	2.177	0.90
101_I	136_D	2.139	0.89
101_I	140_V	2.137	0.89
93_L	146_T	2.134	0.89
210_K	232_T	2.107	0.88
242_R	276_G	2.061	0.87
161_G	273_F	2.057	0.87
231_I	241_T	2.048	0.87
268_Y	331_R	2.032	0.86
22_R	90_Y	2.021	0.86
231_I	245_V	1.997	0.85
188_I	254_L	1.990	0.85
238_D	362_I	1.975	0.85
189_E	192_P	1.939	0.83
204_F	228_S	1.934	0.83
238_D	241_T	1.933	0.83
301_D	381_K	1.899	0.82
160_K	210_K	1.835	0.80
193_D	205_V	1.818	0.79
238_D	273_F	1.800	0.78
78_R	246_R	1.798	0.78
202_A	364_A	1.785	0.78
96_D	248_L	1.780	0.78
89_I	155_I	1.777	0.78
132_Q	263_D	1.751	0.76
373_L	382_I	1.737	0.76
234_A	238_D	1.736	0.76
324_A	357_K	1.726	0.75
91_D	95_S	1.721	0.75
31_Q	36_E	1.711	0.75
234_A	241_T	1.687	0.74
208_V	230_L	1.684	0.74
129_W	150_R	1.666	0.73
210_K	363_E	1.656	0.72
85_M	208_V	1.646	0.72
217_L	230_L	1.629	0.71
165_G	255_P	1.628	0.71
230_L	237_P	1.614	0.70
216_Q	346_W	1.608	0.70
210_K	362_I	1.593	0.69
364_A	369_G	1.591	0.69
259_L	363_E	1.569	0.68
207_V	258_I	1.564	0.68
222_F	226_Y	1.526	0.66
259_L	373_L	1.523	0.66
105_Y	358_A	1.517	0.65
244_F	369_G	1.515	0.65
225_Q	231_I	1.506	0.65
145_F	204_F	1.500	0.64
142_I	354_L	1.496	0.64
266_G	273_F	1.478	0.63
298_S	381_K	1.477	0.63
17_A	21_L	1.454	0.62
211_D	215_Q	1.422	0.60
103_D	212_A	1.402	0.59
101_I	263_D	1.395	0.59
162_K	211_D	1.394	0.59
205_V	244_F	1.390	0.58
207_V	210_K	1.364	0.57
161_G	238_D	1.356	0.56
155_I	254_L	1.352	0.56
104_L	211_D	1.339	0.55
236_Q	268_Y	1.337	0.55
20_I	146_T	1.312	0.54
16_K	19_S	1.312	0.54
136_D	364_A	1.300	0.53
237_P	264_P	1.291	0.53
139_I	221_G	1.291	0.53
160_K	273_F	1.278	0.52
258_I	295_L	1.276	0.52
100_T	240_A	1.268	0.51
210_K	359_K	1.263	0.51
277_S	280_L	1.254	0.50
149_L	230_L	1.251	0.50
146_T	172_G	1.231	0.49
54_E	94_V	1.229	0.49
233_S	245_V	1.228	0.49
233_S	268_Y	1.227	0.49
297_V	376_Q	1.210	0.48
332_A	350_I	1.197	0.47
103_D	335_I	1.197	0.47
232_T	266_G	1.190	0.47
171_S	216_Q	1.187	0.47
271_S	346_W	1.183	0.46
178_L	324_A	1.181	0.46
102_R	106_Y	1.179	0.46
101_I	108_G	1.173	0.46
20_I	23_D	1.172	0.46
89_I	92_A	1.164	0.45
240_A	270_F	1.164	0.45
19_S	23_D	1.160	0.45
229_I	330_K	1.158	0.45
235_G	261_D	1.158	0.45
210_K	238_D	1.154	0.45
32_L	347_E	1.148	0.44
349_E	359_K	1.148	0.44
128_T	267_W	1.147	0.44
65_K	365_M	1.121	0.43
162_K	238_D	1.120	0.43
200_V	252_L	1.120	0.43
210_K	214_F	1.119	0.43
154_L	275_I	1.118	0.43
76_A	365_M	1.112	0.42
216_Q	219_R	1.112	0.42
204_F	226_Y	1.109	0.42
262_A	299_M	1.105	0.42
284_S	288_A	1.103	0.42
268_Y	274_R	1.098	0.41
205_V	256_V	1.098	0.41
297_V	375_F	1.098	0.41
14_R	96_D	1.093	0.41
130_D	331_R	1.092	0.41
234_A	360_L	1.083	0.41
76_A	150_R	1.081	0.40
229_I	248_L	1.071	0.40
79_F	246_R	1.071	0.40
353_F	363_E	1.063	0.39
17_A	32_L	1.060	0.39
230_L	250_E	1.051	0.39
145_F	228_S	1.051	0.39
188_I	192_P	1.046	0.39
230_L	304_G	1.040	0.38
26_L	30_E	1.037	0.38
202_A	254_L	1.027	0.37
295_L	325_K	1.026	0.37
20_I	34_K	1.025	0.37
263_D	269_I	1.025	0.37
200_V	244_F	1.022	0.37
153_M	228_S	1.022	0.37
139_I	306_S	1.016	0.37
263_D	287_L	1.014	0.37
14_R	17_A	1.013	0.37
16_K	34_K	1.013	0.37
140_V	157_S	1.009	0.36
164_V	218_H	1.007	0.36
86_A	199_D	1.004	0.36
236_Q	265_Y	1.003	0.36
143_E	212_A	1.001	0.36
150_R	346_W	1.000	0.36
141_D	365_M	0.994	0.36
210_K	213_V	0.992	0.36
198_I	248_L	0.992	0.36
210_K	233_S	0.990	0.35
46_T	105_Y	0.983	0.35
249_N	256_V	0.981	0.35
344_K	347_E	0.979	0.35
35_G	248_L	0.978	0.35
267_W	353_F	0.977	0.35
153_M	353_F	0.976	0.35
157_S	374_A	0.974	0.35
40_M	79_F	0.974	0.35
71_L	82_T	0.974	0.35
374_A	379_P	0.972	0.34
84_L	101_I	0.964	0.34
155_I	246_R	0.964	0.34
76_A	141_D	0.962	0.34
138_V	145_F	0.961	0.34
287_L	346_W	0.954	0.34
233_S	262_A	0.948	0.33
15_R	28_L	0.948	0.33
42_I	89_I	0.944	0.33
356_R	382_I	0.942	0.33
205_V	245_V	0.937	0.33
97_E	205_V	0.935	0.33
238_D	350_I	0.933	0.32
329_I	354_L	0.932	0.32
238_D	266_G	0.931	0.32
160_K	233_S	0.931	0.32
157_S	160_K	0.925	0.32
101_I	143_E	0.922	0.32
208_V	255_P	0.920	0.32
274_R	331_R	0.916	0.32
160_K	234_A	0.915	0.32
245_V	349_E	0.912	0.31
210_K	266_G	0.910	0.31
167_L	178_L	0.904	0.31
13_A	36_E	0.903	0.31
211_D	236_Q	0.900	0.31
102_R	209_E	0.899	0.31
142_I	265_Y	0.898	0.31
276_G	301_D	0.896	0.31
329_I	357_K	0.895	0.31
16_K	48_S	0.894	0.31
216_Q	365_M	0.886	0.30
136_D	206_L	0.882	0.30
100_T	363_E	0.880	0.30
31_Q	256_V	0.880	0.30
108_G	363_E	0.877	0.30
37_P	100_T	0.872	0.29
237_P	365_M	0.872	0.29
277_S	290_P	0.872	0.29
244_F	349_E	0.871	0.29
165_G	363_E	0.869	0.29
136_D	143_E	0.869	0.29
93_L	145_F	0.858	0.29
63_E	67_K	0.856	0.29
176_I	240_A	0.855	0.29
28_L	83_V	0.855	0.29
210_K	259_L	0.853	0.29
294_F	298_S	0.851	0.28
188_I	241_T	0.848	0.28
106_Y	261_D	0.847	0.28
106_Y	235_G	0.847	0.28
158_K	211_D	0.845	0.28
67_K	288_A	0.845	0.28
210_K	373_L	0.844	0.28
28_L	63_E	0.843	0.28
60_L	104_L	0.840	0.28
282_Y	287_L	0.837	0.28
105_Y	230_L	0.835	0.28
363_E	378_I	0.826	0.27
181_T	382_I	0.826	0.27
166_N	285_E	0.826	0.27
157_S	332_A	0.825	0.27
29_V	38_L	0.821	0.27
108_G	207_V	0.821	0.27
46_T	248_L	0.820	0.27
85_M	353_F	0.820	0.27
92_A	220_A	0.819	0.27
85_M	297_V	0.817	0.27
68_R	82_T	0.816	0.27
64_K	95_S	0.815	0.27
237_P	273_F	0.813	0.27
336_K	347_E	0.813	0.27
217_L	238_D	0.812	0.27
149_L	226_Y	0.811	0.27
188_I	202_A	0.808	0.26
61_L	335_I	0.808	0.26
349_E	365_M	0.807	0.26
90_Y	94_V	0.806	0.26
48_S	176_I	0.805	0.26
54_E	326_E	0.800	0.26
129_W	281_S	0.797	0.26
239_R	368_K	0.797	0.26
136_D	140_V	0.796	0.26
26_L	146_T	0.795	0.26
103_D	213_V	0.794	0.26
214_F	232_T	0.794	0.26
17_A	89_I	0.790	0.26
188_I	193_D	0.790	0.26
204_F	222_F	0.789	0.26
36_E	41_E	0.789	0.26
273_F	359_K	0.785	0.25
154_L	263_D	0.785	0.25
331_R	338_Y	0.784	0.25
36_E	248_L	0.783	0.25
162_K	233_S	0.781	0.25
262_A	287_L	0.780	0.25
160_K	215_Q	0.778	0.25
157_S	212_A	0.778	0.25
32_L	321_I	0.777	0.25
189_E	193_D	0.776	0.25
85_M	139_I	0.776	0.25
183_H	188_I	0.776	0.25
103_D	366_A	0.771	0.25
205_V	262_A	0.770	0.25
16_K	20_I	0.769	0.25
299_M	353_F	0.766	0.25
212_A	271_S	0.766	0.25
23_D	30_E	0.764	0.24
136_D	154_L	0.764	0.24
178_L	202_A	0.762	0.24
324_A	329_I	0.761	0.24
24_K	226_Y	0.758	0.24
161_G	234_A	0.758	0.24
93_L	298_S	0.758	0.24
75_E	205_V	0.758	0.24
68_R	135_S	0.757	0.24
149_L	152_E	0.753	0.24
218_H	295_L	0.752	0.24
139_I	213_V	0.748	0.24
270_F	274_R	0.744	0.24
27_N	170_R	0.744	0.24
296_G	349_E	0.739	0.23
237_P	283_E	0.738	0.23
141_D	276_G	0.738	0.23
107_R	240_A	0.736	0.23
158_K	273_F	0.735	0.23
241_T	350_I	0.735	0.23
305_N	308_K	0.733	0.23
209_E	296_G	0.729	0.23
86_A	214_F	0.729	0.23
85_M	258_I	0.728	0.23
204_F	363_E	0.724	0.23
212_A	232_T	0.723	0.23
91_D	254_L	0.721	0.23
143_E	236_Q	0.720	0.23
161_G	232_T	0.720	0.23
85_M	154_L	0.713	0.22
233_S	331_R	0.711	0.22
140_V	363_E	0.710	0.22
188_I	369_G	0.710	0.22
260_T	325_K	0.709	0.22
178_L	185_A	0.707	0.22
253_K	344_K	0.707	0.22
188_I	354_L	0.705	0.22
52_Y	142_I	0.704	0.22
81_Q	244_F	0.703	0.22
217_L	227_K	0.702	0.22
352_T	355_H	0.696	0.22
85_M	164_V	0.695	0.22
153_M	266_G	0.694	0.22
158_K	219_R	0.694	0.22
15_R	30_E	0.690	0.21
25_F	39_V	0.690	0.21
225_Q	256_V	0.686	0.21
209_E	261_D	0.685	0.21
209_E	235_G	0.685	0.21
259_L	294_F	0.684	0.21
214_F	362_I	0.684	0.21
328_D	359_K	0.681	0.21
263_D	290_P	0.678	0.21
270_F	349_E	0.678	0.21
165_G	276_G	0.678	0.21
151_E	340_W	0.678	0.21
302_I	305_N	0.676	0.21
78_R	206_L	0.676	0.21
155_I	273_F	0.676	0.21
172_G	286_R	0.675	0.21
166_N	270_F	0.674	0.21
70_F	366_A	0.674	0.21
77_K	81_Q	0.673	0.21
17_A	148_L	0.671	0.21
201_D	246_R	0.669	0.21
21_L	133_K	0.668	0.21
105_Y	134_E	0.666	0.20
85_M	104_L	0.666	0.20
153_M	259_L	0.661	0.20
178_L	377_Y	0.661	0.20
260_T	328_D	0.660	0.20
374_A	378_I	0.659	0.20
210_K	273_F	0.659	0.20
263_D	266_G	0.654	0.20
207_V	232_T	0.653	0.20
208_V	214_F	0.651	0.20
258_I	270_F	0.650	0.20
333_E	337_N	0.649	0.20
19_S	63_E	0.648	0.20
65_K	300_S	0.648	0.20
90_Y	160_K	0.647	0.20
262_A	360_L	0.645	0.20
151_E	239_R	0.645	0.20
52_Y	236_Q	0.644	0.20
160_K	211_D	0.644	0.20
197_F	252_L	0.642	0.20
38_L	215_Q	0.640	0.20
154_L	204_F	0.638	0.19
127_N	212_A	0.635	0.19
161_G	233_S	0.635	0.19
74_N	365_M	0.634	0.19
272_V	277_S	0.634	0.19
241_T	244_F	0.633	0.19
80_M	218_H	0.632	0.19
71_L	137_S	0.632	0.19
103_D	346_W	0.631	0.19
143_E	239_R	0.630	0.19
73_M	203_E	0.630	0.19
18_A	94_V	0.628	0.19
86_A	327_A	0.627	0.19
62_G	134_E	0.626	0.19
108_G	324_A	0.626	0.19
211_D	273_F	0.624	0.19
13_A	27_N	0.623	0.19
80_M	172_G	0.620	0.19
14_R	19_S	0.619	0.19
67_K	319_N	0.618	0.19
154_L	213_V	0.617	0.19
196_D	289_T	0.616	0.19
154_L	322_I	0.615	0.19
30_E	34_K	0.615	0.19
236_Q	350_I	0.614	0.19
178_L	237_P	0.611	0.18
102_R	269_I	0.611	0.18
200_V	327_A	0.610	0.18
23_D	46_T	0.608	0.18
79_F	206_L	0.608	0.18
104_L	241_T	0.607	0.18
17_A	35_G	0.606	0.18
258_I	292_A	0.605	0.18
263_D	267_W	0.605	0.18
206_L	257_Y	0.604	0.18
202_A	377_Y	0.602	0.18
227_K	258_I	0.601	0.18
102_R	296_G	0.601	0.18
73_M	196_D	0.601	0.18
103_D	371_K	0.600	0.18
108_G	143_E	0.599	0.18
149_L	341_F	0.599	0.18
169_I	291_D	0.599	0.18
169_I	303_F	0.599	0.18
91_D	295_L	0.594	0.18
160_K	241_T	0.593	0.18
21_L	242_R	0.592	0.18
176_I	244_F	0.591	0.18
20_I	24_K	0.590	0.18
102_R	132_Q	0.588	0.18
298_S	349_E	0.587	0.18
100_T	369_G	0.585	0.18
258_I	278_I	0.582	0.17
45_R	216_Q	0.582	0.17
87_S	164_V	0.582	0.17
211_D	263_D	0.580	0.17
236_Q	273_F	0.580	0.17
214_F	238_D	0.580	0.17
15_R	133_K	0.580	0.17
232_T	237_P	0.580	0.17
20_I	36_E	0.578	0.17
23_D	35_G	0.578	0.17
28_L	38_L	0.577	0.17
15_R	34_K	0.574	0.17
106_Y	161_G	0.573	0.17
92_A	99_P	0.572	0.17
143_E	294_F	0.572	0.17
245_V	298_S	0.571	0.17
85_M	206_L	0.570	0.17
151_E	331_R	0.570	0.17
32_L	309_K	0.566	0.17
158_K	234_A	0.565	0.17
153_M	211_D	0.565	0.17
251_E	364_A	0.565	0.17
89_I	245_V	0.562	0.17
135_S	373_L	0.561	0.17
229_I	344_K	0.561	0.17
100_T	212_A	0.561	0.17
102_R	261_D	0.559	0.17
102_R	235_G	0.559	0.17
325_K	359_K	0.554	0.17
64_K	155_I	0.552	0.16
104_L	344_K	0.552	0.16
105_Y	224_K	0.552	0.16
98_Y	283_E	0.551	0.16
266_G	335_I	0.550	0.16
105_Y	302_I	0.549	0.16
102_R	266_G	0.548	0.16
248_L	372_F	0.548	0.16
233_S	336_K	0.547	0.16
260_T	353_F	0.547	0.16
187_A	349_E	0.546	0.16
45_R	365_M	0.542	0.16
169_I	228_S	0.542	0.16
130_D	342_K	0.540	0.16
18_A	42_I	0.540	0.16
80_M	128_T	0.539	0.16
363_E	366_A	0.539	0.16
84_L	108_G	0.539	0.16
156_L	295_L	0.538	0.16
86_A	89_I	0.537	0.16
89_I	286_R	0.537	0.16
245_V	250_E	0.537	0.16
40_M	72_D	0.536	0.16
40_M	52_Y	0.536	0.16
241_T	324_A	0.535	0.16
369_G	372_F	0.535	0.16
108_G	263_D	0.535	0.16
324_A	332_A	0.535	0.16
79_F	286_R	0.534	0.16
354_L	375_F	0.534	0.16
140_V	265_Y	0.533	0.16
351_N	355_H	0.533	0.16
83_V	227_K	0.532	0.16
101_I	211_D	0.530	0.16
283_E	286_R	0.530	0.16
32_L	376_Q	0.529	0.16
150_R	301_D	0.529	0.16
65_K	323_K	0.528	0.16
128_T	212_A	0.528	0.16
59_L	128_T	0.525	0.16
158_K	233_S	0.523	0.16
136_D	262_A	0.521	0.16
135_S	226_Y	0.520	0.15
342_K	347_E	0.519	0.15
289_T	293_K	0.519	0.15
227_K	251_E	0.517	0.15
212_A	360_L	0.516	0.15
179_S	277_S	0.516	0.15
23_D	26_L	0.515	0.15
191_T	202_A	0.514	0.15
74_N	222_F	0.511	0.15
146_T	154_L	0.510	0.15
211_D	232_T	0.509	0.15
14_R	29_V	0.509	0.15
146_T	167_L	0.508	0.15
45_R	185_A	0.507	0.15
32_L	240_A	0.507	0.15
325_K	349_E	0.506	0.15
86_A	237_P	0.506	0.15
235_G	266_G	0.506	0.15
261_D	266_G	0.506	0.15
27_N	31_Q	0.504	0.15
51_I	224_K	0.502	0.15
133_K	167_L	0.501	0.15
217_L	296_G	0.500	0.15
162_K	187_A	0.500	0.15

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2zbkA	2	0.892	100	0.177	Contact Map
2q2eA	2	0.7943	100	0.204	Contact Map
1d3yA	2	0.7249	100	0.295	Contact Map
1t6t1	2	0.2828	28.9	0.972	Contact Map
2gwrA	1	0.4576	23.5	0.974	Contact Map
3r0jA	2	0.4499	15	0.976	Contact Map
3qxzA	3	0.4884	13.7	0.976	Contact Map
4nekA	4	0.4859	12	0.977	Contact Map
3p5mA	4	0.4807	11.6	0.977	Contact Map
2p3pA	1	0.1722	10.4	0.978	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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