GREMLIN Database
Q97ZE9 - Type 2 DNA topoisomerase 6 subunit A
UniProt: Q97ZE9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 389 (346)
Sequences: 464 (302)
Seq/√Len: 16.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
213_V363_E5.8521.00
163_V244_F4.3541.00
202_A229_I3.6331.00
300_S349_E3.5561.00
166_N201_D3.4610.99
378_I382_I3.2830.99
247_R251_E3.2550.99
22_R100_T3.1380.99
233_S273_F3.0930.99
232_T238_D2.9300.98
270_F294_F2.8960.98
332_A354_L2.8900.98
232_T273_F2.8680.98
207_V292_A2.8110.97
264_P324_A2.8000.97
229_I295_L2.6720.97
256_V292_A2.6370.96
246_R250_E2.6120.96
216_Q220_A2.5610.96
233_S238_D2.5450.95
330_K334_E2.4930.95
268_Y338_Y2.4780.95
362_I373_L2.4360.94
132_Q136_D2.3410.93
82_T245_V2.2880.92
160_K238_D2.1890.90
259_L362_I2.1770.90
101_I136_D2.1390.89
101_I140_V2.1370.89
93_L146_T2.1340.89
210_K232_T2.1070.88
242_R276_G2.0610.87
161_G273_F2.0570.87
231_I241_T2.0480.87
268_Y331_R2.0320.86
22_R90_Y2.0210.86
231_I245_V1.9970.85
188_I254_L1.9900.85
238_D362_I1.9750.85
189_E192_P1.9390.83
204_F228_S1.9340.83
238_D241_T1.9330.83
301_D381_K1.8990.82
160_K210_K1.8350.80
193_D205_V1.8180.79
238_D273_F1.8000.78
78_R246_R1.7980.78
202_A364_A1.7850.78
96_D248_L1.7800.78
89_I155_I1.7770.78
132_Q263_D1.7510.76
373_L382_I1.7370.76
234_A238_D1.7360.76
324_A357_K1.7260.75
91_D95_S1.7210.75
31_Q36_E1.7110.75
234_A241_T1.6870.74
208_V230_L1.6840.74
129_W150_R1.6660.73
210_K363_E1.6560.72
85_M208_V1.6460.72
217_L230_L1.6290.71
165_G255_P1.6280.71
230_L237_P1.6140.70
216_Q346_W1.6080.70
210_K362_I1.5930.69
364_A369_G1.5910.69
259_L363_E1.5690.68
207_V258_I1.5640.68
222_F226_Y1.5260.66
259_L373_L1.5230.66
105_Y358_A1.5170.65
244_F369_G1.5150.65
225_Q231_I1.5060.65
145_F204_F1.5000.64
142_I354_L1.4960.64
266_G273_F1.4780.63
298_S381_K1.4770.63
17_A21_L1.4540.62
211_D215_Q1.4220.60
103_D212_A1.4020.59
101_I263_D1.3950.59
162_K211_D1.3940.59
205_V244_F1.3900.58
207_V210_K1.3640.57
161_G238_D1.3560.56
155_I254_L1.3520.56
104_L211_D1.3390.55
236_Q268_Y1.3370.55
20_I146_T1.3120.54
16_K19_S1.3120.54
136_D364_A1.3000.53
237_P264_P1.2910.53
139_I221_G1.2910.53
160_K273_F1.2780.52
258_I295_L1.2760.52
100_T240_A1.2680.51
210_K359_K1.2630.51
277_S280_L1.2540.50
149_L230_L1.2510.50
146_T172_G1.2310.49
54_E94_V1.2290.49
233_S245_V1.2280.49
233_S268_Y1.2270.49
297_V376_Q1.2100.48
332_A350_I1.1970.47
103_D335_I1.1970.47
232_T266_G1.1900.47
171_S216_Q1.1870.47
271_S346_W1.1830.46
178_L324_A1.1810.46
102_R106_Y1.1790.46
101_I108_G1.1730.46
20_I23_D1.1720.46
89_I92_A1.1640.45
240_A270_F1.1640.45
19_S23_D1.1600.45
229_I330_K1.1580.45
235_G261_D1.1580.45
210_K238_D1.1540.45
32_L347_E1.1480.44
349_E359_K1.1480.44
128_T267_W1.1470.44
65_K365_M1.1210.43
162_K238_D1.1200.43
200_V252_L1.1200.43
210_K214_F1.1190.43
154_L275_I1.1180.43
76_A365_M1.1120.42
216_Q219_R1.1120.42
204_F226_Y1.1090.42
262_A299_M1.1050.42
284_S288_A1.1030.42
268_Y274_R1.0980.41
205_V256_V1.0980.41
297_V375_F1.0980.41
14_R96_D1.0930.41
130_D331_R1.0920.41
234_A360_L1.0830.41
76_A150_R1.0810.40
229_I248_L1.0710.40
79_F246_R1.0710.40
353_F363_E1.0630.39
17_A32_L1.0600.39
230_L250_E1.0510.39
145_F228_S1.0510.39
188_I192_P1.0460.39
230_L304_G1.0400.38
26_L30_E1.0370.38
202_A254_L1.0270.37
295_L325_K1.0260.37
20_I34_K1.0250.37
263_D269_I1.0250.37
200_V244_F1.0220.37
153_M228_S1.0220.37
139_I306_S1.0160.37
263_D287_L1.0140.37
14_R17_A1.0130.37
16_K34_K1.0130.37
140_V157_S1.0090.36
164_V218_H1.0070.36
86_A199_D1.0040.36
236_Q265_Y1.0030.36
143_E212_A1.0010.36
150_R346_W1.0000.36
141_D365_M0.9940.36
210_K213_V0.9920.36
198_I248_L0.9920.36
210_K233_S0.9900.35
46_T105_Y0.9830.35
249_N256_V0.9810.35
344_K347_E0.9790.35
35_G248_L0.9780.35
267_W353_F0.9770.35
153_M353_F0.9760.35
157_S374_A0.9740.35
40_M79_F0.9740.35
71_L82_T0.9740.35
374_A379_P0.9720.34
84_L101_I0.9640.34
155_I246_R0.9640.34
76_A141_D0.9620.34
138_V145_F0.9610.34
287_L346_W0.9540.34
233_S262_A0.9480.33
15_R28_L0.9480.33
42_I89_I0.9440.33
356_R382_I0.9420.33
205_V245_V0.9370.33
97_E205_V0.9350.33
238_D350_I0.9330.32
329_I354_L0.9320.32
238_D266_G0.9310.32
160_K233_S0.9310.32
157_S160_K0.9250.32
101_I143_E0.9220.32
208_V255_P0.9200.32
274_R331_R0.9160.32
160_K234_A0.9150.32
245_V349_E0.9120.31
210_K266_G0.9100.31
167_L178_L0.9040.31
13_A36_E0.9030.31
211_D236_Q0.9000.31
102_R209_E0.8990.31
142_I265_Y0.8980.31
276_G301_D0.8960.31
329_I357_K0.8950.31
16_K48_S0.8940.31
216_Q365_M0.8860.30
136_D206_L0.8820.30
100_T363_E0.8800.30
31_Q256_V0.8800.30
108_G363_E0.8770.30
37_P100_T0.8720.29
237_P365_M0.8720.29
277_S290_P0.8720.29
244_F349_E0.8710.29
165_G363_E0.8690.29
136_D143_E0.8690.29
93_L145_F0.8580.29
63_E67_K0.8560.29
176_I240_A0.8550.29
28_L83_V0.8550.29
210_K259_L0.8530.29
294_F298_S0.8510.28
188_I241_T0.8480.28
106_Y261_D0.8470.28
106_Y235_G0.8470.28
158_K211_D0.8450.28
67_K288_A0.8450.28
210_K373_L0.8440.28
28_L63_E0.8430.28
60_L104_L0.8400.28
282_Y287_L0.8370.28
105_Y230_L0.8350.28
363_E378_I0.8260.27
181_T382_I0.8260.27
166_N285_E0.8260.27
157_S332_A0.8250.27
29_V38_L0.8210.27
108_G207_V0.8210.27
46_T248_L0.8200.27
85_M353_F0.8200.27
92_A220_A0.8190.27
85_M297_V0.8170.27
68_R82_T0.8160.27
64_K95_S0.8150.27
237_P273_F0.8130.27
336_K347_E0.8130.27
217_L238_D0.8120.27
149_L226_Y0.8110.27
188_I202_A0.8080.26
61_L335_I0.8080.26
349_E365_M0.8070.26
90_Y94_V0.8060.26
48_S176_I0.8050.26
54_E326_E0.8000.26
129_W281_S0.7970.26
239_R368_K0.7970.26
136_D140_V0.7960.26
26_L146_T0.7950.26
103_D213_V0.7940.26
214_F232_T0.7940.26
17_A89_I0.7900.26
188_I193_D0.7900.26
204_F222_F0.7890.26
36_E41_E0.7890.26
273_F359_K0.7850.25
154_L263_D0.7850.25
331_R338_Y0.7840.25
36_E248_L0.7830.25
162_K233_S0.7810.25
262_A287_L0.7800.25
160_K215_Q0.7780.25
157_S212_A0.7780.25
32_L321_I0.7770.25
189_E193_D0.7760.25
85_M139_I0.7760.25
183_H188_I0.7760.25
103_D366_A0.7710.25
205_V262_A0.7700.25
16_K20_I0.7690.25
299_M353_F0.7660.25
212_A271_S0.7660.25
23_D30_E0.7640.24
136_D154_L0.7640.24
178_L202_A0.7620.24
324_A329_I0.7610.24
24_K226_Y0.7580.24
161_G234_A0.7580.24
93_L298_S0.7580.24
75_E205_V0.7580.24
68_R135_S0.7570.24
149_L152_E0.7530.24
218_H295_L0.7520.24
139_I213_V0.7480.24
270_F274_R0.7440.24
27_N170_R0.7440.24
296_G349_E0.7390.23
237_P283_E0.7380.23
141_D276_G0.7380.23
107_R240_A0.7360.23
158_K273_F0.7350.23
241_T350_I0.7350.23
305_N308_K0.7330.23
209_E296_G0.7290.23
86_A214_F0.7290.23
85_M258_I0.7280.23
204_F363_E0.7240.23
212_A232_T0.7230.23
91_D254_L0.7210.23
143_E236_Q0.7200.23
161_G232_T0.7200.23
85_M154_L0.7130.22
233_S331_R0.7110.22
140_V363_E0.7100.22
188_I369_G0.7100.22
260_T325_K0.7090.22
178_L185_A0.7070.22
253_K344_K0.7070.22
188_I354_L0.7050.22
52_Y142_I0.7040.22
81_Q244_F0.7030.22
217_L227_K0.7020.22
352_T355_H0.6960.22
85_M164_V0.6950.22
153_M266_G0.6940.22
158_K219_R0.6940.22
15_R30_E0.6900.21
25_F39_V0.6900.21
225_Q256_V0.6860.21
209_E261_D0.6850.21
209_E235_G0.6850.21
259_L294_F0.6840.21
214_F362_I0.6840.21
328_D359_K0.6810.21
263_D290_P0.6780.21
270_F349_E0.6780.21
165_G276_G0.6780.21
151_E340_W0.6780.21
302_I305_N0.6760.21
78_R206_L0.6760.21
155_I273_F0.6760.21
172_G286_R0.6750.21
166_N270_F0.6740.21
70_F366_A0.6740.21
77_K81_Q0.6730.21
17_A148_L0.6710.21
201_D246_R0.6690.21
21_L133_K0.6680.21
105_Y134_E0.6660.20
85_M104_L0.6660.20
153_M259_L0.6610.20
178_L377_Y0.6610.20
260_T328_D0.6600.20
374_A378_I0.6590.20
210_K273_F0.6590.20
263_D266_G0.6540.20
207_V232_T0.6530.20
208_V214_F0.6510.20
258_I270_F0.6500.20
333_E337_N0.6490.20
19_S63_E0.6480.20
65_K300_S0.6480.20
90_Y160_K0.6470.20
262_A360_L0.6450.20
151_E239_R0.6450.20
52_Y236_Q0.6440.20
160_K211_D0.6440.20
197_F252_L0.6420.20
38_L215_Q0.6400.20
154_L204_F0.6380.19
127_N212_A0.6350.19
161_G233_S0.6350.19
74_N365_M0.6340.19
272_V277_S0.6340.19
241_T244_F0.6330.19
80_M218_H0.6320.19
71_L137_S0.6320.19
103_D346_W0.6310.19
143_E239_R0.6300.19
73_M203_E0.6300.19
18_A94_V0.6280.19
86_A327_A0.6270.19
62_G134_E0.6260.19
108_G324_A0.6260.19
211_D273_F0.6240.19
13_A27_N0.6230.19
80_M172_G0.6200.19
14_R19_S0.6190.19
67_K319_N0.6180.19
154_L213_V0.6170.19
196_D289_T0.6160.19
154_L322_I0.6150.19
30_E34_K0.6150.19
236_Q350_I0.6140.19
178_L237_P0.6110.18
102_R269_I0.6110.18
200_V327_A0.6100.18
23_D46_T0.6080.18
79_F206_L0.6080.18
104_L241_T0.6070.18
17_A35_G0.6060.18
258_I292_A0.6050.18
263_D267_W0.6050.18
206_L257_Y0.6040.18
202_A377_Y0.6020.18
227_K258_I0.6010.18
102_R296_G0.6010.18
73_M196_D0.6010.18
103_D371_K0.6000.18
108_G143_E0.5990.18
149_L341_F0.5990.18
169_I291_D0.5990.18
169_I303_F0.5990.18
91_D295_L0.5940.18
160_K241_T0.5930.18
21_L242_R0.5920.18
176_I244_F0.5910.18
20_I24_K0.5900.18
102_R132_Q0.5880.18
298_S349_E0.5870.18
100_T369_G0.5850.18
258_I278_I0.5820.17
45_R216_Q0.5820.17
87_S164_V0.5820.17
211_D263_D0.5800.17
236_Q273_F0.5800.17
214_F238_D0.5800.17
15_R133_K0.5800.17
232_T237_P0.5800.17
20_I36_E0.5780.17
23_D35_G0.5780.17
28_L38_L0.5770.17
15_R34_K0.5740.17
106_Y161_G0.5730.17
92_A99_P0.5720.17
143_E294_F0.5720.17
245_V298_S0.5710.17
85_M206_L0.5700.17
151_E331_R0.5700.17
32_L309_K0.5660.17
158_K234_A0.5650.17
153_M211_D0.5650.17
251_E364_A0.5650.17
89_I245_V0.5620.17
135_S373_L0.5610.17
229_I344_K0.5610.17
100_T212_A0.5610.17
102_R261_D0.5590.17
102_R235_G0.5590.17
325_K359_K0.5540.17
64_K155_I0.5520.16
104_L344_K0.5520.16
105_Y224_K0.5520.16
98_Y283_E0.5510.16
266_G335_I0.5500.16
105_Y302_I0.5490.16
102_R266_G0.5480.16
248_L372_F0.5480.16
233_S336_K0.5470.16
260_T353_F0.5470.16
187_A349_E0.5460.16
45_R365_M0.5420.16
169_I228_S0.5420.16
130_D342_K0.5400.16
18_A42_I0.5400.16
80_M128_T0.5390.16
363_E366_A0.5390.16
84_L108_G0.5390.16
156_L295_L0.5380.16
86_A89_I0.5370.16
89_I286_R0.5370.16
245_V250_E0.5370.16
40_M72_D0.5360.16
40_M52_Y0.5360.16
241_T324_A0.5350.16
369_G372_F0.5350.16
108_G263_D0.5350.16
324_A332_A0.5350.16
79_F286_R0.5340.16
354_L375_F0.5340.16
140_V265_Y0.5330.16
351_N355_H0.5330.16
83_V227_K0.5320.16
101_I211_D0.5300.16
283_E286_R0.5300.16
32_L376_Q0.5290.16
150_R301_D0.5290.16
65_K323_K0.5280.16
128_T212_A0.5280.16
59_L128_T0.5250.16
158_K233_S0.5230.16
136_D262_A0.5210.16
135_S226_Y0.5200.15
342_K347_E0.5190.15
289_T293_K0.5190.15
227_K251_E0.5170.15
212_A360_L0.5160.15
179_S277_S0.5160.15
23_D26_L0.5150.15
191_T202_A0.5140.15
74_N222_F0.5110.15
146_T154_L0.5100.15
211_D232_T0.5090.15
14_R29_V0.5090.15
146_T167_L0.5080.15
45_R185_A0.5070.15
32_L240_A0.5070.15
325_K349_E0.5060.15
86_A237_P0.5060.15
235_G266_G0.5060.15
261_D266_G0.5060.15
27_N31_Q0.5040.15
51_I224_K0.5020.15
133_K167_L0.5010.15
217_L296_G0.5000.15
162_K187_A0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zbkA 2 0.892 100 0.177 Contact Map
2q2eA 2 0.7943 100 0.204 Contact Map
1d3yA 2 0.7249 100 0.295 Contact Map
1t6t1 2 0.2828 28.9 0.972 Contact Map
2gwrA 1 0.4576 23.5 0.974 Contact Map
3r0jA 2 0.4499 15 0.976 Contact Map
3qxzA 3 0.4884 13.7 0.976 Contact Map
4nekA 4 0.4859 12 0.977 Contact Map
3p5mA 4 0.4807 11.6 0.977 Contact Map
2p3pA 1 0.1722 10.4 0.978 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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