GREMLIN Database
IF5A - Translation initiation factor 5A
UniProt: Q97ZE8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 131 (127)
Sequences: 487 (253)
Seq/√Len: 22.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_V122_M5.2201.00
19_I46_A4.4201.00
11_L26_V4.1671.00
42_A61_V3.4021.00
104_D107_A2.9821.00
85_I127_I2.9770.99
39_S63_Q2.9040.99
22_E124_R2.6460.99
27_V47_I2.5800.99
11_L17_V2.5500.98
43_N58_M2.4300.98
9_G62_D2.3830.97
17_V65_V2.0930.95
75_G87_V1.8390.90
118_Y127_I1.8050.89
8_V29_V1.7860.88
9_G29_V1.7720.88
101_P106_L1.7530.87
36_K41_K1.6860.85
37_H41_K1.6680.85
8_V26_V1.6570.84
6_T10_E1.6550.84
48_G51_S1.6410.84
6_T67_V1.6200.83
119_W128_V1.4870.77
83_N111_K1.4230.74
37_H40_A1.4050.73
8_V17_V1.3680.71
8_V11_L1.3650.70
70_I123_G1.3250.68
48_G55_K1.3190.68
87_V116_L1.3060.67
8_V61_V1.3010.67
107_A110_I1.2750.65
36_K40_A1.2750.65
25_R31_K1.2640.64
33_K59_A1.2540.64
105_E108_S1.2130.61
28_E45_V1.1610.58
9_G61_V1.1340.56
51_S55_K1.1090.54
16_Y122_M1.0970.53
29_V42_A1.0830.52
26_V29_V1.0670.51
76_Q90_L1.0620.51
46_A55_K1.0600.51
79_A86_Q1.0490.50
116_L127_I1.0270.48
43_N51_S1.0200.48
4_T69_I1.0120.47
111_K127_I0.9950.46
42_A126_K0.9700.45
99_E113_N0.9690.44
76_Q119_W0.9650.44
86_Q96_F0.9490.43
89_D93_Y0.9460.43
34_T43_N0.9430.43
17_V42_A0.9400.42
46_A65_V0.9380.42
13_V25_R0.9370.42
39_S57_L0.9330.42
47_I122_M0.9320.42
33_K40_A0.9220.41
33_K60_P0.9120.41
61_V126_K0.9100.40
87_V121_I0.9070.40
19_I130_V0.9030.40
15_S67_V0.9030.40
73_H78_I0.8970.40
107_A111_K0.8960.40
78_I94_E0.8860.39
28_E83_N0.8830.39
86_Q93_Y0.8830.39
76_Q88_M0.8830.39
98_I127_I0.8760.38
83_N107_A0.8650.38
77_I80_D0.8650.38
85_I100_K0.8640.37
88_M119_W0.8630.37
10_E17_V0.8530.37
86_Q95_T0.8510.37
119_W129_R0.8410.36
21_G52_G0.8380.36
39_S64_Q0.8360.36
35_G41_K0.8360.36
11_L29_V0.8300.35
121_I125_R0.8230.35
7_T64_Q0.8190.35
38_G41_K0.7990.33
29_V44_V0.7990.33
45_V122_M0.7980.33
18_V127_I0.7940.33
7_T28_E0.7930.33
15_S101_P0.7900.33
72_K119_W0.7850.33
15_S92_S0.7820.32
73_H89_D0.7800.32
79_A90_L0.7770.32
11_L107_A0.7700.32
73_H85_I0.7570.31
76_Q79_A0.7550.31
21_G66_E0.7540.31
79_A126_K0.7460.30
23_P45_V0.7430.30
39_S62_D0.7420.30
50_F56_T0.7390.30
24_C45_V0.7340.30
116_L122_M0.7330.30
54_K65_V0.7310.29
47_I54_K0.7290.29
77_I129_R0.7280.29
84_K97_E0.7230.29
8_V65_V0.7220.29
32_A35_G0.7190.29
77_I85_I0.7150.28
27_V34_T0.7110.28
6_T15_S0.7070.28
8_V42_A0.7070.28
12_K29_V0.7000.28
70_I94_E0.6860.27
34_T59_A0.6820.27
73_H88_M0.6780.26
9_G15_S0.6730.26
36_K39_S0.6720.26
73_H79_A0.6660.26
47_I98_I0.6620.26
9_G12_K0.6610.26
14_G129_R0.6590.25
101_P111_K0.6530.25
55_K73_H0.6520.25
74_I117_E0.6480.25
5_Y13_V0.6470.25
17_V98_I0.6470.25
44_V61_V0.6420.25
39_S59_A0.6380.24
54_K95_T0.6310.24
9_G33_K0.6300.24
19_I98_I0.6300.24
40_A60_P0.6290.24
75_G96_F0.6260.24
26_V66_E0.6180.23
57_L63_Q0.6170.23
109_K122_M0.6130.23
27_V31_K0.6130.23
44_V65_V0.6120.23
17_V114_A0.6100.23
31_K64_Q0.6030.23
98_I109_K0.6010.23
83_N100_K0.5970.22
29_V62_D0.5940.22
16_Y115_E0.5890.22
46_A95_T0.5860.22
30_T110_I0.5850.22
21_G60_P0.5850.22
87_V96_F0.5840.22
14_G117_E0.5830.22
80_D100_K0.5820.22
78_I88_M0.5800.22
67_V123_G0.5800.22
102_T107_A0.5750.21
5_Y45_V0.5730.21
79_A111_K0.5710.21
77_I116_L0.5680.21
60_P63_Q0.5620.21
92_S110_I0.5620.21
5_Y64_Q0.5570.21
31_K63_Q0.5550.20
85_I110_I0.5510.20
22_E48_G0.5460.20
8_V44_V0.5450.20
33_K54_K0.5430.20
91_E115_E0.5410.20
78_I96_F0.5380.20
3_I18_V0.5300.19
78_I86_Q0.5270.19
117_E129_R0.5260.19
117_E121_I0.5250.19
5_Y9_G0.5240.19
27_V45_V0.5220.19
14_G27_V0.5190.19
91_E107_A0.5180.19
86_Q94_E0.5160.19
29_V102_T0.5120.19
45_V119_W0.5100.18
44_V126_K0.5080.18
46_A49_V0.5060.18
95_T112_P0.5050.18
101_P107_A0.5030.18
73_H91_E0.5000.18
47_I52_G0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1khiA 1 0.9466 100 0.318 Contact Map
1bkbA 3 1 100 0.378 Contact Map
1x6oA 1 0.9618 100 0.378 Contact Map
3er0A 1 0.9924 100 0.386 Contact Map
3hksA 1 1 100 0.399 Contact Map
3cpfA 1 0.9618 100 0.399 Contact Map
1iz6A 1 0.9924 100 0.404 Contact Map
2eifA 1 0.9771 100 0.406 Contact Map
1ybyA 2 0.9389 99.9 0.539 Contact Map
3a5zB 1 0.9466 99.9 0.542 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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