GREMLIN Database
SRP54 - Signal recognition particle 54 kDa protein
UniProt: Q97ZE7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 447 (429)
Sequences: 2869 (1369)
Seq/√Len: 66.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
147_G154_V5.1061.00
101_L113_A4.1111.00
312_K334_A3.9481.00
203_K236_A3.8531.00
231_S235_Q3.7001.00
330_R390_E3.6881.00
141_D144_L3.5721.00
337_I378_L3.5001.00
24_D52_K3.2721.00
173_I177_N3.2591.00
191_G225_K3.2471.00
234_H265_A2.9951.00
157_E169_K2.9581.00
200_E204_E2.9401.00
114_G276_I2.8951.00
401_R405_E2.8451.00
340_R378_L2.8071.00
273_G278_E2.7241.00
113_A183_I2.7071.00
172_D176_K2.5981.00
333_Y382_N2.5881.00
184_V209_L2.5351.00
114_G146_L2.4811.00
46_S261_V2.4601.00
410_E413_E2.4411.00
153_Q179_M2.4141.00
64_L301_L2.3941.00
395_I418_L2.3861.00
130_V170_G2.3211.00
167_A209_L2.3201.00
77_E80_K2.3071.00
47_L51_I2.2941.00
155_Y169_K2.2841.00
165_E169_K2.2761.00
113_A129_L2.2691.00
332_V421_Y2.2611.00
162_N204_E2.1921.00
144_L148_N2.1751.00
162_N165_E2.1671.00
404_A414_V2.1501.00
387_K394_I2.1501.00
122_K306_G2.1431.00
312_K315_K2.1061.00
132_A167_A2.0691.00
129_L147_G2.0681.00
298_E301_L2.0461.00
329_L418_L2.0291.00
164_I208_V2.0181.00
317_M321_M2.0101.00
80_K84_G2.0031.00
120_Y181_I1.9881.00
380_A414_V1.9641.00
310_Y314_Q1.9621.00
121_K152_V1.9381.00
121_K151_G1.9341.00
213_D268_K1.8901.00
125_Y181_I1.8781.00
215_I243_I1.8621.00
72_S76_D1.8541.00
54_R77_E1.8491.00
62_S311_D1.8491.00
352_I355_L1.8361.00
378_L382_N1.8101.00
117_A152_V1.8061.00
15_G22_A1.7921.00
247_M270_I1.7831.00
376_R413_E1.7781.00
54_R76_D1.7671.00
395_I403_I1.7601.00
129_L183_I1.7561.00
49_A53_E1.7130.99
128_G173_I1.7120.99
126_K179_M1.7020.99
239_I265_A1.6970.99
46_S50_K1.6690.99
214_V237_S1.6460.99
314_Q317_M1.6370.99
92_P97_F1.6340.99
171_V182_I1.6280.99
164_I204_E1.6180.99
86_K281_T1.6120.99
200_E203_K1.6120.99
247_M287_F1.6090.99
134_V166_I1.6030.99
206_Y238_P1.6010.99
75_Y79_S1.5970.99
50_K80_K1.5790.99
376_R409_L1.5780.99
144_L156_G1.5720.99
89_N120_Y1.5670.99
215_I241_S1.5660.99
127_V179_M1.5570.99
205_M209_L1.5430.99
330_R386_Y1.5320.99
387_K391_N1.5320.99
130_V182_I1.5250.99
92_P95_L1.5210.99
421_Y425_N1.5110.99
372_E375_R1.4940.99
135_Y166_I1.4880.99
146_L150_I1.4860.99
356_G360_P1.4830.99
54_R80_K1.4790.98
328_T390_E1.4620.98
116_L243_I1.4610.98
98_I184_V1.4580.98
75_Y289_S1.4550.98
409_L413_E1.4290.98
49_A52_K1.4280.98
286_R302_E1.4240.98
118_Y277_D1.4220.98
206_Y214_V1.4110.98
93_T97_F1.4100.98
12_F26_F1.3930.98
148_N151_G1.3910.98
127_V153_Q1.3860.98
400_M418_L1.3860.98
134_V163_P1.3850.98
150_I276_I1.3770.98
303_K351_H1.3750.98
311_D315_K1.3700.98
218_I259_A1.3650.97
23_V56_N1.3650.97
27_I52_K1.3590.97
119_F269_F1.3560.97
172_D175_V1.3500.97
146_L276_I1.3470.97
98_I171_V1.3400.97
244_I256_A1.3330.97
112_T271_G1.3250.97
50_K77_E1.3210.97
119_F123_R1.3110.97
128_G179_M1.3030.97
130_V167_A1.2950.96
10_R14_T1.2880.96
97_F212_D1.2850.96
232_R236_A1.2830.96
203_K207_D1.2760.96
380_A417_L1.2750.96
46_S49_A1.2700.96
129_L154_V1.2660.96
173_I179_M1.2660.96
5_I8_A1.2550.96
191_G232_R1.2520.96
309_E312_K1.2470.96
99_I183_I1.2460.96
272_T279_L1.2430.96
170_G182_I1.2430.96
270_I287_F1.2340.95
345_L349_L1.2190.95
225_K228_D1.2150.95
305_K310_Y1.2120.95
337_I382_N1.2080.95
370_G375_R1.2060.95
347_K350_Q1.1970.95
340_R375_R1.1890.94
167_A208_V1.1880.94
112_T243_I1.1870.94
164_I205_M1.1840.94
397_K400_M1.1790.94
283_N299_S1.1690.94
98_I182_I1.1680.94
91_N95_L1.1640.94
344_P347_K1.1640.94
27_I51_I1.1570.93
332_V336_I1.1520.93
196_T200_E1.1470.93
393_N422_N1.1470.93
64_L298_E1.1460.93
118_Y121_K1.1410.93
168_K208_V1.1320.93
147_G153_Q1.1290.93
21_K25_E1.1280.93
147_G150_I1.1270.93
100_M202_M1.1220.92
22_A70_F1.1210.92
9_V12_F1.1150.92
173_I176_K1.1140.92
128_G153_Q1.1120.92
27_I48_T1.1070.92
213_D240_G1.1030.92
314_Q318_E1.1010.92
160_N165_E1.0960.91
169_K172_D1.0930.91
333_Y378_L1.0920.91
355_L358_M1.0910.91
191_G229_L1.0900.91
165_E168_K1.0810.91
11_K25_E1.0760.91
54_R59_K1.0750.91
118_Y279_L1.0710.91
168_K172_D1.0690.90
91_N181_I1.0650.90
397_K411_V1.0600.90
333_Y337_I1.0510.90
4_N36_S1.0440.89
407_S410_E1.0400.89
434_R437_N1.0390.89
131_A157_E1.0330.89
225_K229_L1.0290.89
118_Y276_I1.0290.89
107_S113_A1.0180.88
386_Y390_E1.0150.88
145_Q148_N1.0130.88
204_E208_V1.0130.88
101_L243_I1.0130.88
161_Q165_E1.0110.88
337_I340_R1.0080.88
27_I70_F1.0050.88
256_A267_I1.0040.87
380_A409_L0.9950.87
10_R15_G0.9900.87
308_E313_I0.9900.87
372_E376_R0.9880.87
344_P348_V0.9850.86
171_V209_L0.9770.86
211_P214_V0.9770.86
393_N425_N0.9760.86
7_D11_K0.9760.86
100_M184_V0.9750.86
153_Q173_I0.9730.86
285_K298_E0.9730.86
315_K318_E0.9710.86
135_Y201_E0.9690.86
358_M361_T0.9680.85
220_A247_M0.9660.85
118_Y150_I0.9660.85
198_L202_M0.9590.85
131_A140_Y0.9590.85
196_T236_A0.9510.84
238_P265_A0.9470.84
50_K261_V0.9430.84
373_K420_W0.9430.84
283_N286_R0.9400.84
28_K32_K0.9400.84
167_A171_V0.9380.84
329_L394_I0.9310.83
88_P123_R0.9280.83
321_M432_K0.9240.83
57_K60_P0.9190.82
380_A404_A0.9190.82
19_Y22_A0.9160.82
21_K24_D0.9140.82
121_K150_I0.9020.81
164_I171_V0.9020.81
58_E62_S0.9000.81
112_T279_L0.8950.81
423_N426_R0.8910.80
98_I212_D0.8900.80
157_E161_Q0.8900.80
99_I181_I0.8890.80
336_I424_M0.8890.80
93_T212_D0.8860.80
345_L348_V0.8830.80
125_Y180_D0.8820.80
231_S234_H0.8810.80
229_L232_R0.8790.79
158_P161_Q0.8780.79
55_L73_I0.8700.79
18_P70_F0.8700.79
171_V175_V0.8620.78
286_R299_S0.8590.78
206_Y239_I0.8590.78
86_K283_N0.8590.78
332_V377_W0.8590.78
26_F70_F0.8580.78
121_K148_N0.8540.77
76_D298_E0.8470.77
409_L412_E0.8450.77
18_P23_V0.8400.76
215_I268_K0.8370.76
311_D314_Q0.8320.76
68_E297_I0.8310.76
101_L271_G0.8310.76
128_G182_I0.8290.75
135_Y163_P0.8290.75
247_M272_T0.8280.75
130_V184_V0.8280.75
370_G373_K0.8270.75
301_L305_K0.8270.75
356_G359_L0.8250.75
232_R235_Q0.8250.75
94_K97_F0.8230.75
17_T59_K0.8200.75
303_K306_G0.8180.74
119_F281_T0.8170.74
23_V70_F0.8170.74
50_K53_E0.8170.74
10_R13_L0.8140.74
234_H239_I0.8130.74
326_K425_N0.8130.74
117_A150_I0.8090.74
101_L112_T0.8080.73
227_Y262_A0.8080.73
65_E68_E0.8070.73
288_V291_I0.8050.73
144_L154_V0.8030.73
131_A156_G0.8010.73
30_L71_I0.8000.73
83_G284_A0.7980.73
100_M214_V0.7970.72
171_V208_V0.7960.72
373_K376_R0.7960.72
90_V212_D0.7950.72
91_N97_F0.7930.72
84_G260_V0.7900.72
285_K289_S0.7900.72
400_M415_R0.7870.71
9_V18_P0.7870.71
127_V212_D0.7850.71
218_I244_I0.7830.71
140_Y158_P0.7810.71
387_K390_E0.7810.71
20_E56_N0.7760.70
128_G177_N0.7760.70
114_G149_Q0.7740.70
267_I270_I0.7680.70
141_D158_P0.7660.69
30_L70_F0.7640.69
161_Q169_K0.7610.69
204_E207_D0.7610.69
242_V259_A0.7600.69
316_K320_V0.7600.69
164_I209_L0.7590.69
426_R430_M0.7590.69
317_M320_V0.7570.68
350_Q359_L0.7550.68
89_N99_I0.7550.68
369_I375_R0.7540.68
164_I167_A0.7540.68
132_A184_V0.7540.68
31_Q44_V0.7430.67
316_K325_G0.7420.67
357_I360_P0.7420.67
375_R382_N0.7410.67
72_S305_K0.7410.67
329_L421_Y0.7380.67
303_K307_L0.7380.67
370_G376_R0.7380.67
114_G150_I0.7380.67
140_Y157_E0.7350.66
425_N429_K0.7340.66
315_K328_T0.7300.66
7_D10_R0.7280.65
118_Y122_K0.7280.65
413_E416_E0.7280.65
183_I279_L0.7280.65
207_D210_K0.7260.65
22_A25_E0.7250.65
332_V427_L0.7250.65
149_Q278_E0.7220.65
144_L158_P0.7200.65
184_V205_M0.7200.65
345_L361_T0.7200.65
366_Q370_G0.7190.65
216_L242_V0.7160.64
146_L149_Q0.7150.64
86_K89_N0.7140.64
416_E420_W0.7130.64
131_A154_V0.7100.64
319_D328_T0.7100.64
312_K341_K0.7100.64
340_R371_E0.7090.63
297_I301_L0.7080.63
58_E311_D0.7070.63
434_R438_I0.7070.63
391_N394_I0.7030.63
37_S252_K0.7030.63
107_S220_A0.7020.63
141_D145_Q0.7020.63
326_K393_N0.7010.63
218_I392_P0.7010.63
240_G265_A0.7010.63
407_S412_E0.7010.63
355_L360_P0.7000.62
422_N425_N0.7000.62
349_L352_I0.6990.62
45_F49_A0.6970.62
134_V201_E0.6950.62
9_V16_S0.6930.62
375_R378_L0.6910.61
381_L389_L0.6880.61
420_W424_M0.6830.61
348_V352_I0.6830.61
373_K424_M0.6830.61
9_V26_F0.6810.60
89_N215_I0.6800.60
239_I271_G0.6790.60
338_A342_M0.6790.60
346_S361_T0.6760.60
373_K413_E0.6760.60
61_P301_L0.6740.60
192_Y200_E0.6730.59
67_K71_I0.6720.59
147_G152_V0.6690.59
102_V152_V0.6680.59
396_D400_M0.6680.59
73_I309_E0.6670.59
27_I30_L0.6660.59
120_Y268_K0.6650.58
156_G161_Q0.6590.58
68_E294_M0.6590.58
283_N302_E0.6590.58
435_R438_I0.6570.58
155_Y173_I0.6560.57
127_V180_D0.6560.57
346_S368_K0.6530.57
383_S406_G0.6530.57
216_L229_L0.6530.57
199_L225_K0.6530.57
6_R357_I0.6530.57
84_G87_E0.6510.57
397_K401_R0.6510.57
420_W423_N0.6510.57
131_A333_Y0.6460.56
129_L153_Q0.6460.56
167_A184_V0.6460.56
141_D159_N0.6460.56
325_G425_N0.6450.56
336_I374_I0.6420.56
156_G159_N0.6410.56
318_E324_K0.6400.56
318_E321_M0.6390.55
302_E305_K0.6380.55
18_P26_F0.6360.55
9_V67_K0.6340.55
30_L82_F0.6340.55
101_L183_I0.6330.55
112_T272_T0.6320.55
23_V27_I0.6320.55
332_V347_K0.6310.55
303_K347_K0.6290.54
271_G401_R0.6290.54
23_V26_F0.6280.54
71_I298_E0.6280.54
321_M324_K0.6260.54
325_G432_K0.6260.54
272_T303_K0.6250.54
330_R382_N0.6250.54
269_F281_T0.6250.54
344_P352_I0.6250.54
394_I418_L0.6230.54
81_L240_G0.6230.54
2_L356_G0.6230.54
316_K319_D0.6230.54
129_L143_L0.6220.53
97_F125_Y0.6220.53
4_N31_Q0.6220.53
150_I154_V0.6200.53
422_N426_R0.6190.53
134_V157_E0.6190.53
105_Q190_H0.6190.53
202_M214_V0.6160.53
197_K200_E0.6140.53
356_G361_T0.6140.53
14_T19_Y0.6140.53
61_P76_D0.6130.52
295_G353_P0.6130.52
28_K45_F0.6120.52
141_D148_N0.6110.52
303_K410_E0.6100.52
3_E7_D0.6100.52
319_D331_D0.6090.52
305_K308_E0.6070.52
196_T387_K0.6070.52
157_E160_N0.6060.52
50_K348_V0.6050.52
92_P212_D0.6030.51
342_M348_V0.6030.51
352_I356_G0.6030.51
10_R22_A0.6020.51
272_T280_E0.6020.51
91_N125_Y0.5990.51
22_A301_L0.5980.51
76_D301_L0.5970.51
111_T271_G0.5960.50
61_P69_W0.5960.50
332_V425_N0.5930.50
332_V378_L0.5930.50
360_P366_Q0.5930.50
182_I209_L0.5930.50
346_S350_Q0.5920.50
13_L119_F0.5910.50
131_A147_G0.5910.50
32_K35_I0.5910.50
421_Y428_L0.5910.50
172_D207_D0.5900.50
418_L421_Y0.5900.50
51_I319_D0.5890.50
199_L221_S0.5880.49
144_L147_G0.5880.49
61_P64_L0.5880.49
234_H237_S0.5870.49
51_I74_V0.5870.49
85_D88_P0.5860.49
51_I55_L0.5860.49
135_Y198_L0.5860.49
150_I153_Q0.5850.49
164_I242_V0.5840.49
222_I226_A0.5840.49
18_P74_V0.5830.49
202_M232_R0.5820.49
18_P60_P0.5820.49
205_M208_V0.5810.49
315_K319_D0.5800.49
191_G202_M0.5800.49
82_F287_F0.5790.48
379_A409_L0.5760.48
52_K56_N0.5750.48
131_A212_D0.5750.48
242_V265_A0.5740.48
158_P246_K0.5740.48
202_M229_L0.5730.48
366_Q369_I0.5710.47
98_I175_V0.5710.47
210_K240_G0.5700.47
221_S250_T0.5690.47
162_N170_G0.5680.47
33_S256_A0.5670.47
402_R406_G0.5670.47
91_N212_D0.5660.47
101_L116_L0.5660.47
238_P356_G0.5650.47
411_V415_R0.5650.47
219_D246_K0.5620.46
349_L355_L0.5610.46
60_P73_I0.5600.46
373_K416_E0.5580.46
72_S222_I0.5570.46
176_K235_Q0.5560.46
298_E305_K0.5550.46
171_V205_M0.5550.46
124_G156_G0.5550.46
121_K149_Q0.5540.46
344_P350_Q0.5540.46
8_A70_F0.5540.46
157_E165_E0.5530.45
4_N9_V0.5520.45
278_E281_T0.5520.45
22_A30_L0.5510.45
11_K16_S0.5510.45
200_E207_D0.5510.45
102_V214_V0.5490.45
159_N162_N0.5480.45
97_F131_A0.5480.45
157_E166_I0.5480.45
175_V346_S0.5470.45
82_F220_A0.5470.45
330_R333_Y0.5460.45
175_V200_E0.5460.45
260_V264_G0.5460.45
140_Y246_K0.5450.44
126_K178_K0.5450.44
387_K414_V0.5450.44
186_T294_M0.5440.44
41_V45_F0.5440.44
22_A67_K0.5440.44
118_Y149_Q0.5430.44
8_A11_K0.5430.44
352_I359_L0.5430.44
396_D418_L0.5420.44
175_V212_D0.5420.44
140_Y163_P0.5410.44
134_V140_Y0.5390.44
346_S371_E0.5380.44
280_E287_F0.5380.44
339_L352_I0.5380.44
24_D234_H0.5360.43
45_F50_K0.5350.43
65_E293_G0.5350.43
304_V308_E0.5350.43
252_K288_V0.5340.43
299_S302_E0.5340.43
78_L297_I0.5330.43
64_L69_W0.5330.43
393_N396_D0.5330.43
94_K175_V0.5320.43
58_E73_I0.5310.43
429_K433_R0.5300.43
131_A161_Q0.5300.43
132_A170_G0.5270.42
369_I373_K0.5260.42
222_I355_L0.5260.42
198_L271_G0.5260.42
4_N392_P0.5260.42
64_L68_E0.5260.42
35_I51_I0.5250.42
335_Q339_L0.5240.42
105_Q221_S0.5240.42
94_K212_D0.5230.42
433_R438_I0.5230.42
163_P205_M0.5220.42
64_L146_L0.5220.42
87_E260_V0.5220.42
191_G228_D0.5210.42
207_D386_Y0.5210.42
160_N169_K0.5200.42
84_G89_N0.5200.42
54_R60_P0.5190.41
112_T239_I0.5190.41
215_I407_S0.5180.41
202_M231_S0.5170.41
373_K377_W0.5170.41
149_Q275_K0.5170.41
164_I168_K0.5160.41
190_H225_K0.5160.41
376_R425_N0.5150.41
324_K429_K0.5150.41
149_Q276_I0.5150.41
341_K346_S0.5150.41
87_E90_V0.5140.41
30_L244_I0.5130.41
134_V160_N0.5130.41
370_G379_A0.5130.41
339_L377_W0.5130.41
13_L357_I0.5120.41
329_L411_V0.5110.41
320_V324_K0.5110.41
49_A101_L0.5110.41
221_S291_I0.5100.40
259_A347_K0.5090.40
270_I299_S0.5090.40
216_L239_I0.5090.40
105_Q199_L0.5090.40
411_V429_K0.5070.40
71_I294_M0.5070.40
190_H202_M0.5060.40
329_L381_L0.5040.40
396_D403_I0.5040.40
348_V376_R0.5040.40
182_I264_G0.5040.40
337_I350_Q0.5040.40
34_L44_V0.5030.40
92_P96_P0.5030.40
308_E347_K0.5030.40
344_P377_W0.5030.40
368_K375_R0.5030.40
410_E416_E0.5030.40
14_T22_A0.5020.40
252_K291_I0.5020.40
245_T249_G0.5010.39
18_P22_A0.5000.39
321_M332_V0.5000.39
129_L209_L0.5000.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ffhA 4 0.9016 100 0.388 Contact Map
2v3cC 1 0.8904 100 0.392 Contact Map
2xxaA 1 0.9172 100 0.398 Contact Map
2j37W 1 0.9754 100 0.415 Contact Map
3kl4A 1 0.9172 100 0.435 Contact Map
3dm5A 4 0.9172 100 0.445 Contact Map
4c7oA 1 0.6555 100 0.619 Contact Map
1ls1A 1 0.6376 100 0.634 Contact Map
2yhsA 1 0.6353 100 0.654 Contact Map
2og2A 1 0.6398 100 0.656 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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