GREMLIN Database
Q97ZE6 - Uncharacterized protein
UniProt: Q97ZE6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 370 (336)
Sequences: 217 (174)
Seq/√Len: 9.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
275_I283_K4.9761.00
27_C30_C3.3340.95
30_C33_R3.2220.94
332_L336_L2.9600.91
249_T297_R2.8500.89
275_I281_V2.7680.88
58_I324_I2.7640.88
27_C33_R2.7140.87
167_R171_K2.6210.85
245_S297_R2.6080.85
354_D357_G2.3440.77
244_F256_Y2.3060.76
246_E249_T2.3030.76
240_I258_I2.2900.76
297_R331_E2.2410.74
348_L362_I2.2380.74
44_N48_G2.2230.73
235_L238_R2.1850.72
292_A301_V2.1820.72
328_S331_E2.1270.70
346_I362_I2.1250.70
249_T331_E2.0850.68
102_C107_N2.0720.68
159_E164_E2.0400.67
258_I332_L2.0170.66
223_W335_K1.9780.64
26_L32_G1.9420.63
297_R328_S1.9300.62
218_L338_K1.9200.62
245_S331_E1.9110.61
332_L335_K1.9100.61
331_E341_S1.8740.60
225_S228_G1.8610.59
258_I334_E1.8540.59
213_R244_F1.8520.59
223_W235_L1.8340.58
120_A204_N1.8240.58
213_R256_Y1.8130.57
185_P193_L1.8080.57
54_S58_I1.7960.56
130_K161_I1.7920.56
348_L360_K1.7830.56
247_P297_R1.7750.55
32_G44_N1.7480.54
249_T328_S1.7450.54
220_I236_L1.7090.52
244_F247_P1.7060.52
31_L35_F1.6900.52
283_K286_L1.6460.50
235_L335_K1.6450.50
173_L260_I1.6340.49
335_K341_S1.6330.49
246_E297_R1.6300.49
28_D32_G1.6210.48
252_I297_R1.6130.48
245_S328_S1.5990.48
309_L358_R1.5940.47
122_K125_S1.5930.47
331_E335_K1.5720.46
173_L183_D1.5650.46
173_L353_I1.5530.45
246_E331_E1.5380.45
220_I244_F1.5340.45
247_P256_Y1.5330.45
258_I336_L1.5120.44
244_F255_D1.5030.43
245_S249_T1.4910.43
32_G48_G1.4880.43
304_Y356_K1.4700.42
47_R52_K1.4660.42
67_E75_K1.4600.41
220_I256_Y1.4590.41
247_P329_F1.4540.41
221_S240_I1.4430.41
44_N52_K1.4380.40
300_R361_D1.4360.40
48_G52_K1.4240.40
251_R301_V1.4220.40
247_P331_E1.4130.39
235_L258_I1.4080.39
239_K262_N1.4040.39
255_D326_A1.4010.39
26_L36_A1.3970.39
166_K291_A1.3960.39
187_V239_K1.3940.39
40_Y51_I1.3900.38
135_G330_S1.3890.38
47_R50_A1.3880.38
59_L64_K1.3850.38
31_L36_A1.3790.38
96_E353_I1.3770.38
328_S341_S1.3770.38
54_S57_L1.3700.38
222_S237_Q1.3650.37
51_I57_L1.3580.37
213_R297_R1.3580.37
218_L222_S1.3540.37
292_A302_T1.3530.37
137_E365_N1.3470.37
220_I336_L1.3460.37
74_I77_I1.3450.36
235_L329_F1.3410.36
46_E49_R1.3240.36
297_R341_S1.3130.35
159_E171_K1.3090.35
138_L191_Y1.3080.35
297_R335_K1.3030.35
124_L154_T1.3010.35
249_T329_F1.2920.34
208_F264_G1.2810.34
44_N47_R1.2660.33
46_E55_L1.2560.33
242_F248_T1.2490.33
259_V345_I1.2470.33
47_R164_E1.2470.33
243_A327_K1.2450.32
245_S255_D1.2360.32
124_L200_I1.2340.32
244_F341_S1.2300.32
322_L362_I1.2290.32
60_D64_K1.2220.32
187_V195_D1.2160.31
213_R255_D1.2150.31
256_Y341_S1.2090.31
326_A341_S1.2020.31
49_R58_I1.2020.31
235_L276_F1.2010.31
129_V239_K1.2000.31
139_D145_K1.1970.31
249_T341_S1.1950.31
209_Y245_S1.1830.30
131_S207_T1.1770.30
164_E167_R1.1750.30
25_P32_G1.1700.30
235_L336_L1.1660.29
297_R329_F1.1620.29
238_R258_I1.1610.29
167_R185_P1.1590.29
128_G312_A1.1520.29
53_I57_L1.1480.29
47_R57_L1.1480.29
120_A173_L1.1440.29
213_R220_I1.1390.28
247_P328_S1.1340.28
164_E170_G1.1160.28
24_Y36_A1.1150.28
209_Y247_P1.1130.28
235_L247_P1.1090.27
328_S335_K1.1080.27
61_E85_A1.1050.27
28_D44_N1.1020.27
289_I302_T1.1010.27
29_S43_E1.0990.27
32_G47_R1.0990.27
223_W238_R1.0960.27
50_A54_S1.0930.27
228_G237_Q1.0870.27
239_K281_V1.0850.27
246_E328_S1.0840.26
348_L365_N1.0810.26
181_N281_V1.0790.26
209_Y258_I1.0570.26
50_A53_I1.0550.25
90_K313_I1.0530.25
32_G36_A1.0410.25
216_R253_L1.0340.25
250_V257_P1.0310.25
144_K222_S1.0300.25
152_E324_I1.0300.25
223_W336_L1.0260.25
111_D278_V1.0260.25
236_L281_V1.0210.24
300_R359_I1.0190.24
202_S265_R1.0150.24
163_H242_F1.0130.24
49_R54_S1.0120.24
245_S329_F1.0120.24
252_I331_E1.0080.24
32_G43_E1.0030.24
209_Y297_R1.0020.24
338_K356_K1.0010.24
50_A57_L0.9920.23
235_L244_F0.9900.23
327_K338_K0.9810.23
232_L243_A0.9790.23
146_E260_I0.9780.23
98_H177_G0.9740.23
90_K123_L0.9700.23
132_Y169_V0.9700.23
245_S341_S0.9650.23
329_F341_S0.9640.23
360_K365_N0.9640.23
213_R247_P0.9630.22
213_R341_S0.9590.22
110_E220_I0.9570.22
96_E100_H0.9570.22
300_R362_I0.9520.22
290_S320_Y0.9520.22
56_M59_L0.9510.22
223_W246_E0.9500.22
137_E199_F0.9480.22
34_C250_V0.9450.22
24_Y32_G0.9450.22
160_S219_P0.9430.22
249_T252_I0.9370.22
162_K166_K0.9360.22
326_A329_F0.9360.22
246_E261_E0.9360.22
235_L297_R0.9360.22
249_T335_K0.9340.22
32_G35_F0.9310.22
109_I290_S0.9300.21
187_V277_K0.9280.21
244_F326_A0.9280.21
246_E341_S0.9270.21
247_P252_I0.9250.21
215_N218_L0.9250.21
243_A292_A0.9230.21
119_K198_V0.9170.21
351_D361_D0.9140.21
174_S177_G0.9140.21
238_R335_K0.9100.21
261_E297_R0.9100.21
25_P37_R0.9020.21
244_F297_R0.8980.21
159_E167_R0.8980.21
222_S248_T0.8980.21
218_L232_L0.8960.20
326_A331_E0.8940.20
32_G52_K0.8920.20
256_Y326_A0.8910.20
148_K161_I0.8890.20
48_G55_L0.8860.20
172_T237_Q0.8850.20
122_K316_Y0.8840.20
139_D301_V0.8820.20
219_P261_E0.8780.20
46_E57_L0.8780.20
212_N241_V0.8780.20
252_I328_S0.8770.20
248_T333_N0.8740.20
24_Y47_R0.8740.20
206_R283_K0.8720.20
231_G333_N0.8710.20
38_L48_G0.8700.20
245_S326_A0.8690.20
209_Y235_L0.8650.20
256_Y297_R0.8650.20
224_F237_Q0.8640.20
142_T277_K0.8630.20
42_L57_L0.8620.19
34_C40_Y0.8600.19
222_S231_G0.8590.19
249_T256_Y0.8580.19
48_G57_L0.8580.19
213_R326_A0.8540.19
246_E257_P0.8530.19
59_L90_K0.8530.19
47_R170_G0.8410.19
223_W333_N0.8400.19
210_V258_I0.8360.19
26_L35_F0.8280.19
135_G167_R0.8240.18
106_Q166_K0.8220.18
59_L117_S0.8210.18
31_L34_C0.8180.18
216_R261_E0.8180.18
264_G295_T0.8170.18
244_F329_F0.8110.18
209_Y244_F0.8110.18
302_T357_G0.8100.18
272_G284_K0.8080.18
245_S252_I0.8050.18
185_P195_D0.7990.18
176_R302_T0.7920.18
33_R102_C0.7910.18
256_Y329_F0.7900.18
254_A326_A0.7880.18
278_V343_Y0.7880.18
29_S34_C0.7870.17
351_D357_G0.7840.17
242_F280_T0.7810.17
184_N362_I0.7790.17
207_T237_Q0.7770.17
216_R254_A0.7760.17
244_F249_T0.7740.17
46_E53_I0.7730.17
262_N265_R0.7720.17
46_E60_D0.7710.17
235_L256_Y0.7680.17
237_Q303_V0.7670.17
58_I61_E0.7670.17
35_F43_E0.7660.17
53_I58_I0.7640.17
50_A55_L0.7640.17
145_K222_S0.7600.17
193_L237_Q0.7580.17
244_F331_E0.7570.17
25_P47_R0.7550.17
52_K55_L0.7520.17
215_N301_V0.7510.17
187_V301_V0.7490.17
186_E355_V0.7450.16
181_N314_R0.7440.16
230_E261_E0.7430.16
227_Q333_N0.7420.16
295_T366_Y0.7420.16
28_D48_G0.7400.16
220_I332_L0.7390.16
215_N337_S0.7380.16
256_Y331_E0.7360.16
207_T262_N0.7350.16
153_F311_D0.7340.16
245_S256_Y0.7340.16
173_L205_I0.7340.16
245_S335_K0.7330.16
362_I367_L0.7320.16
219_P354_D0.7320.16
45_K50_A0.7250.16
52_K59_L0.7230.16
163_H166_K0.7230.16
26_L31_L0.7220.16
240_I283_K0.7210.16
94_S196_L0.7190.16
117_S149_I0.7180.16
295_T302_T0.7150.16
175_K179_P0.7140.16
28_D31_L0.7140.16
116_F138_L0.7130.16
31_L108_K0.7120.16
28_D35_F0.7110.16
81_L86_E0.7090.16
217_N310_S0.7070.16
214_L266_D0.7040.15
209_Y255_D0.7020.15
291_A301_V0.7010.15
118_D134_L0.7000.15
303_V309_L0.6990.15
235_L332_L0.6990.15
105_C299_Y0.6970.15
213_R235_L0.6920.15
244_F254_A0.6910.15
241_V303_V0.6900.15
237_Q334_E0.6880.15
239_K285_E0.6870.15
101_P314_R0.6870.15
221_S319_I0.6860.15
55_L324_I0.6860.15
250_V295_T0.6850.15
46_E52_K0.6840.15
38_L47_R0.6840.15
127_L139_D0.6830.15
247_P255_D0.6820.15
235_L245_S0.6810.15
35_F51_I0.6780.15
167_R186_E0.6730.15
241_V276_F0.6710.15
246_E256_Y0.6690.15
178_Y194_S0.6670.15
74_I79_E0.6650.15
295_T364_E0.6620.14
203_K217_N0.6610.14
197_Q212_N0.6590.14
79_E205_I0.6560.14
48_G164_E0.6560.14
235_L249_T0.6540.14
80_N85_A0.6520.14
28_D50_A0.6500.14
213_R245_S0.6500.14
38_L64_K0.6490.14
224_F312_A0.6420.14
121_F323_Y0.6420.14
198_V277_K0.6410.14
145_K243_A0.6400.14
346_I353_I0.6390.14
25_P31_L0.6360.14
130_K231_G0.6350.14
82_G85_A0.6350.14
50_A149_I0.6350.14
301_V365_N0.6310.14
120_A134_L0.6310.14
328_S333_N0.6310.14
159_E208_F0.6240.14
35_F44_N0.6240.14
147_S219_P0.6210.14
254_A283_K0.6200.14
320_Y323_Y0.6200.14
326_A332_L0.6180.14
46_E50_A0.6180.14
140_E148_K0.6160.13
332_L341_S0.6150.13
255_D341_S0.6140.13
173_L292_A0.6120.13
252_I339_L0.6110.13
290_S304_Y0.6100.13
219_P325_D0.6100.13
293_K301_V0.6080.13
24_Y34_C0.6050.13
58_I62_K0.6040.13
187_V262_N0.6020.13
174_S274_Y0.6020.13
136_V304_Y0.6020.13
223_W258_I0.5990.13
206_R278_V0.5990.13
136_V200_I0.5990.13
92_Y95_S0.5980.13
26_L39_G0.5950.13
115_D198_V0.5940.13
329_F335_K0.5940.13
329_F332_L0.5920.13
172_T175_K0.5910.13
170_G345_I0.5910.13
221_S246_E0.5900.13
218_L365_N0.5890.13
220_I341_S0.5880.13
213_R254_A0.5870.13
173_L176_R0.5870.13
300_R346_I0.5860.13
24_Y44_N0.5850.13
199_F324_I0.5810.13
39_G42_L0.5810.13
39_G44_N0.5800.13
219_P315_V0.5790.13
79_E85_A0.5790.13
77_I80_N0.5780.13
268_I289_I0.5750.13
223_W257_P0.5750.13
326_A335_K0.5740.13
38_L44_N0.5740.13
209_Y334_E0.5740.13
206_R332_L0.5740.13
352_L356_K0.5730.13
179_P284_K0.5730.13
192_R271_G0.5710.13
132_Y266_D0.5710.13
160_S302_T0.5700.13
77_I81_L0.5700.13
180_P189_I0.5690.13
213_R329_F0.5680.13
209_Y249_T0.5660.12
171_K182_M0.5660.12
102_C109_I0.5660.12
235_L255_D0.5660.12
250_V253_L0.5660.12
124_L324_I0.5650.12
28_D47_R0.5650.12
232_L337_S0.5630.12
127_L138_L0.5630.12
191_Y306_T0.5620.12
134_L169_V0.5620.12
109_I178_Y0.5610.12
189_I214_L0.5590.12
134_L188_E0.5580.12
53_I62_K0.5580.12
59_L63_I0.5570.12
281_V286_L0.5570.12
221_S302_T0.5570.12
40_Y66_H0.5560.12
146_E164_E0.5540.12
159_E225_S0.5540.12
97_F204_N0.5510.12
245_S254_A0.5490.12
125_S275_I0.5480.12
277_K314_R0.5460.12
210_V240_I0.5440.12
102_C105_C0.5440.12
61_E64_K0.5430.12
108_K311_D0.5420.12
36_A274_Y0.5420.12
226_K291_A0.5380.12
259_V343_Y0.5370.12
360_K367_L0.5370.12
80_N84_I0.5360.12
329_F343_Y0.5350.12
105_C216_R0.5350.12
105_C211_Y0.5340.12
27_C32_G0.5320.12
301_V348_L0.5320.12
246_E252_I0.5320.12
245_S261_E0.5280.12
328_S332_L0.5280.12
177_G187_V0.5240.12
173_L189_I0.5220.12
82_G88_W0.5220.12
213_R331_E0.5220.12
38_L57_L0.5210.12
223_W332_L0.5210.12
214_L217_N0.5200.12
146_E290_S0.5180.12
163_H171_K0.5180.12
208_F287_Q0.5140.12
156_M309_L0.5130.11
219_P297_R0.5130.11
238_R276_F0.5110.11
59_L66_H0.5100.11
228_G242_F0.5090.11
82_G86_E0.5060.11
251_R358_R0.5030.11
227_Q248_T0.5020.11
164_E168_E0.5020.11
99_S173_L0.5010.11
55_L59_L0.5010.11
165_I303_V0.5010.11
44_N57_L0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2v9kA 1 0.8757 100 0.357 Contact Map
2apoA 1 0.3459 96.8 0.942 Contact Map
2ausC 1 0.3459 96.7 0.942 Contact Map
1r3eA 1 0.3108 96.3 0.945 Contact Map
1k8wA 1 0.3135 95.4 0.949 Contact Map
3u28A 1 0.4162 94.4 0.952 Contact Map
2dirA 1 0.2486 49.1 0.97 Contact Map
1sgvA 1 0.2865 18.7 0.976 Contact Map
2hjhA 2 0.1514 10.2 0.979 Contact Map
4jonA 1 0.2865 6.8 0.98 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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