Q97ZE5 - SULSO - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

Q97ZE5 - 3-hydroxyisobutyrate dehydrogenase

UniProt:	Q97ZE5	Sequences: MKIGLIGLGIMGYRIAANLAKANKLNLVYDRTQEKIESFVKEYKVNGVQNTKDLVESSDVIITMLADDYAVKSVVEPLIPLMKGKILIDMSTISPTLSISLAKRIESNGGTMFDAPVIGTSVFVEQKKLVVLVGGPKDKFDIVNDIAKETASLVVYMGPNGMGLYSKLVNNLLLASYVAAIAEAYNFGIRAGLEPQQVVNILTTLSSARSPTTELKAPKLLKEDYSTQFATKHMRKDLEIIMREAQNLKIITPVSSLVLELYKMAEALGYSEADFISVVEVFKKLSPKT	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	289 (276)
Sequences:	11402 (7257)
Seq/√Len:	436.8

ECOLI - GARR YGBJ GLXR SQUU 6PGD
BACSU - YKWC YFJR YQEC 6PGD 6PGDH
HALSA - Q9HMG5
SULSO - Q97ZE5 Q97XZ7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
144_N	148_K	3.702	1.00
72_K	100_S	3.451	1.00
137_K	141_D	3.347	1.00
27_L	48_V	3.193	1.00
111_T	139_K	2.955	1.00
40_V	47_G	2.909	1.00
111_T	142_I	2.783	1.00
232_K	272_E	2.392	1.00
141_D	144_N	2.267	1.00
49_Q	53_D	2.238	1.00
36_I	47_G	2.227	1.00
105_I	110_G	2.183	1.00
4_G	54_L	2.180	1.00
20_A	45_V	2.172	1.00
37_E	41_K	2.147	1.00
86_I	143_V	2.104	1.00
24_K	149_E	1.992	1.00
13_Y	38_S	1.984	1.00
50_N	53_D	1.969	1.00
209_R	214_E	1.955	1.00
137_K	156_Y	1.952	1.00
79_I	105_I	1.940	1.00
194_E	197_Q	1.918	1.00
111_T	136_P	1.887	1.00
63_T	87_L	1.876	1.00
96_T	247_N	1.854	1.00
25_L	46_N	1.845	1.00
18_N	21_K	1.844	1.00
82_M	85_K	1.834	1.00
22_A	149_E	1.788	1.00
244_E	247_N	1.779	1.00
232_K	266_E	1.745	1.00
188_G	198_V	1.742	1.00
32_T	35_K	1.737	1.00
102_A	160_N	1.735	1.00
34_E	37_E	1.723	1.00
75_V	87_L	1.721	1.00
106_E	136_P	1.707	1.00
136_P	139_K	1.684	1.00
103_K	107_S	1.683	1.00
131_V	150_T	1.663	1.00
33_Q	37_E	1.661	1.00
81_L	85_K	1.648	1.00
28_V	45_V	1.640	1.00
270_Y	273_A	1.636	1.00
64_M	90_M	1.621	1.00
86_I	139_K	1.619	1.00
104_R	107_S	1.585	1.00
113_F	135_G	1.583	1.00
131_V	151_A	1.563	1.00
102_A	106_E	1.553	1.00
140_F	144_N	1.552	1.00
100_S	104_R	1.538	1.00
140_F	156_Y	1.515	1.00
115_A	131_V	1.504	1.00
113_F	143_V	1.499	1.00
54_L	58_S	1.489	1.00
18_N	127_K	1.487	1.00
62_I	90_M	1.477	1.00
196_Q	200_N	1.468	1.00
67_D	70_A	1.463	1.00
52_K	56_E	1.457	1.00
27_L	46_N	1.456	1.00
218_P	222_K	1.449	1.00
122_V	126_Q	1.436	1.00
68_D	97_L	1.416	1.00
176_S	180_A	1.412	1.00
27_L	57_S	1.409	1.00
121_S	125_E	1.406	1.00
37_E	40_V	1.405	1.00
260_E	263_K	1.397	1.00
157_M	166_S	1.395	1.00
231_T	265_A	1.390	1.00
168_L	240_I	1.380	1.00
189_I	195_P	1.368	1.00
256_S	260_E	1.364	1.00
257_L	260_E	1.360	1.00
232_K	271_S	1.341	1.00
98_S	112_M	1.338	1.00
259_L	263_K	1.332	1.00
33_Q	49_Q	1.324	1.00
128_K	152_S	1.314	1.00
57_S	82_M	1.314	1.00
86_I	142_I	1.313	1.00
99_I	160_N	1.308	1.00
79_I	108_N	1.305	1.00
59_D	82_M	1.285	1.00
105_I	112_M	1.282	1.00
113_F	140_F	1.274	1.00
14_R	125_E	1.273	1.00
88_I	143_V	1.268	1.00
273_A	280_E	1.262	1.00
64_M	117_V	1.256	1.00
203_T	214_E	1.234	1.00
60_V	86_I	1.234	1.00
21_K	125_E	1.234	1.00
235_R	266_E	1.228	1.00
246_Q	256_S	1.228	1.00
4_G	58_S	1.228	1.00
17_A	125_E	1.222	1.00
186_N	190_R	1.213	1.00
136_P	159_P	1.208	1.00
245_A	252_T	1.204	1.00
16_A	26_N	1.201	1.00
77_P	80_P	1.197	1.00
85_K	110_G	1.193	1.00
69_Y	73_S	1.189	1.00
81_L	110_G	1.185	1.00
175_A	234_M	1.179	1.00
143_V	147_A	1.179	1.00
99_I	165_Y	1.175	1.00
60_V	146_I	1.172	1.00
5_L	15_I	1.160	1.00
80_P	108_N	1.158	1.00
72_K	104_R	1.156	1.00
175_A	238_L	1.152	1.00
5_L	16_A	1.149	1.00
243_R	247_N	1.147	1.00
27_L	58_S	1.145	1.00
90_M	131_V	1.144	1.00
94_S	97_L	1.139	1.00
38_S	41_K	1.126	1.00
87_L	105_I	1.123	1.00
20_A	44_K	1.122	1.00
5_L	62_I	1.117	1.00
251_I	256_S	1.116	1.00
65_L	74_V	1.116	1.00
191_A	248_L	1.113	1.00
39_F	45_V	1.106	1.00
159_P	162_M	1.092	1.00
17_A	21_K	1.084	1.00
68_D	94_S	1.077	1.00
242_M	256_S	1.074	1.00
104_R	108_N	1.065	1.00
72_K	97_L	1.065	1.00
90_M	150_T	1.064	1.00
10_I	121_S	1.060	1.00
235_R	263_K	1.055	1.00
99_I	103_K	1.055	1.00
133_V	140_F	1.054	1.00
30_D	35_K	1.048	1.00
62_I	146_I	1.041	1.00
102_A	136_P	1.033	1.00
239_E	259_L	1.029	1.00
52_K	77_P	1.028	1.00
148_K	154_V	1.023	1.00
48_V	53_D	1.021	1.00
103_K	106_E	1.017	1.00
81_L	87_L	1.016	1.00
173_L	184_A	1.011	1.00
33_Q	47_G	1.006	1.00
48_V	54_L	1.002	1.00
243_R	246_Q	1.002	1.00
114_D	161_G	1.001	1.00
231_T	266_E	0.998	1.00
197_Q	200_N	0.991	1.00
156_Y	159_P	0.985	1.00
75_V	78_L	0.985	1.00
76_E	80_P	0.980	1.00
113_F	133_V	0.980	1.00
70_A	73_S	0.967	1.00
62_I	88_I	0.962	1.00
169_V	184_A	0.948	1.00
211_P	215_L	0.943	1.00
185_Y	199_V	0.943	1.00
169_V	188_G	0.942	1.00
132_L	201_I	0.941	1.00
31_R	70_A	0.940	1.00
239_E	243_R	0.938	1.00
75_V	105_I	0.934	1.00
83_K	109_G	0.930	1.00
141_D	156_Y	0.926	1.00
118_I	170_N	0.926	1.00
229_F	233_H	0.918	1.00
94_S	243_R	0.917	1.00
124_V	129_L	0.911	1.00
71_V	93_I	0.909	1.00
176_S	254_V	0.907	1.00
157_M	162_M	0.905	1.00
135_G	140_F	0.904	1.00
190_R	250_I	0.904	1.00
97_L	100_S	0.903	1.00
76_E	104_R	0.902	1.00
199_V	217_A	0.900	1.00
34_E	38_S	0.900	1.00
86_I	111_T	0.900	1.00
72_K	101_L	0.899	1.00
273_A	277_S	0.899	1.00
8_L	39_F	0.898	1.00
18_N	150_T	0.897	1.00
203_T	213_T	0.894	1.00
263_K	267_A	0.894	1.00
199_V	203_T	0.889	1.00
118_I	132_L	0.887	1.00
5_L	26_N	0.887	1.00
239_E	263_K	0.886	1.00
165_Y	191_A	0.885	1.00
266_E	271_S	0.883	1.00
13_Y	17_A	0.880	1.00
157_M	201_I	0.877	1.00
8_L	28_V	0.867	1.00
145_D	148_K	0.864	1.00
53_D	56_E	0.860	1.00
98_S	164_L	0.859	1.00
139_K	142_I	0.856	1.00
27_L	54_L	0.854	1.00
165_Y	244_E	0.854	1.00
93_I	97_L	0.854	1.00
235_R	259_L	0.853	1.00
270_Y	280_E	0.850	1.00
15_I	150_T	0.850	1.00
19_L	62_I	0.847	1.00
35_K	38_S	0.843	1.00
60_V	142_I	0.837	1.00
179_A	254_V	0.831	1.00
100_S	103_K	0.828	1.00
88_I	115_A	0.824	1.00
96_T	99_I	0.818	1.00
99_I	161_G	0.812	1.00
114_D	163_G	0.811	1.00
166_S	193_L	0.809	1.00
196_Q	222_K	0.806	1.00
226_S	273_A	0.802	1.00
265_A	277_S	0.802	1.00
203_T	209_R	0.802	1.00
230_A	272_E	0.802	1.00
51_T	55_V	0.800	1.00
61_I	78_L	0.800	1.00
63_T	71_V	0.797	1.00
230_A	233_H	0.790	1.00
172_L	255_S	0.790	1.00
137_K	159_P	0.789	1.00
254_V	258_V	0.782	1.00
134_G	163_G	0.781	1.00
177_Y	210_S	0.780	1.00
66_A	70_A	0.776	1.00
3_I	24_K	0.775	1.00
139_K	143_V	0.772	1.00
92_T	240_I	0.767	1.00
225_Y	280_E	0.767	1.00
177_Y	181_I	0.767	1.00
89_D	112_M	0.762	1.00
264_M	268_L	0.761	1.00
140_F	154_V	0.758	1.00
172_L	241_I	0.757	1.00
217_A	220_L	0.757	1.00
190_R	248_L	0.755	1.00
264_M	281_V	0.753	1.00
111_T	138_D	0.751	1.00
182_A	278_V	0.749	1.00
15_I	90_M	0.749	1.00
242_M	259_L	0.749	1.00
147_A	154_V	0.746	1.00
31_R	35_K	0.745	1.00
60_V	88_I	0.742	1.00
28_V	36_I	0.738	1.00
144_N	154_V	0.734	1.00
244_E	248_L	0.734	1.00
181_I	213_T	0.733	1.00
120_T	123_F	0.732	1.00
63_T	75_V	0.731	1.00
231_T	277_S	0.731	1.00
65_L	70_A	0.728	1.00
173_L	181_I	0.727	1.00
15_I	129_L	0.726	1.00
188_G	193_L	0.726	1.00
6_I	29_Y	0.723	1.00
265_A	270_Y	0.722	1.00
113_F	139_K	0.721	1.00
5_L	64_M	0.720	1.00
19_L	26_N	0.713	1.00
33_Q	36_I	0.710	1.00
79_I	110_G	0.710	1.00
3_I	146_I	0.709	1.00
263_K	266_E	0.708	1.00
101_L	112_M	0.707	1.00
196_Q	221_L	0.706	1.00
24_K	146_I	0.705	1.00
217_A	221_L	0.704	1.00
246_Q	259_L	0.703	1.00
15_I	64_M	0.701	1.00
155_V	201_I	0.701	1.00
186_N	189_I	0.695	1.00
20_A	26_N	0.690	1.00
268_L	281_V	0.687	1.00
265_A	281_V	0.684	1.00
264_M	267_A	0.677	1.00
6_I	51_T	0.677	1.00
61_I	81_L	0.675	1.00
261_L	264_M	0.675	1.00
53_D	57_S	0.671	1.00
36_I	40_V	0.670	1.00
177_Y	212_T	0.669	1.00
138_D	141_D	0.669	1.00
3_I	19_L	0.668	1.00
97_L	101_L	0.664	1.00
65_L	71_V	0.663	1.00
173_L	180_A	0.663	1.00
153_L	200_N	0.661	1.00
115_A	133_V	0.659	1.00
133_V	147_A	0.655	1.00
165_Y	193_L	0.651	0.99
153_L	204_T	0.651	0.99
52_K	76_E	0.648	0.99
79_I	104_R	0.648	0.99
82_M	110_G	0.648	0.99
71_V	91_S	0.645	0.99
166_S	198_V	0.645	0.99
13_Y	39_F	0.643	0.99
187_F	252_T	0.642	0.99
173_L	177_Y	0.641	0.99
52_K	80_P	0.641	0.99
73_S	77_P	0.640	0.99
112_M	160_N	0.640	0.99
277_S	280_E	0.637	0.99
134_G	156_Y	0.631	0.99
260_E	264_M	0.631	0.99
173_L	202_L	0.629	0.99
169_V	187_F	0.629	0.99
123_F	128_K	0.628	0.99
71_V	89_D	0.627	0.99
168_L	241_I	0.624	0.99
16_A	28_V	0.623	0.99
73_S	76_E	0.623	0.99
144_N	156_Y	0.619	0.99
17_A	20_A	0.619	0.99
219_K	224_D	0.618	0.99
178_V	275_F	0.618	0.99
137_K	140_F	0.618	0.99
193_L	198_V	0.614	0.99
176_S	258_V	0.613	0.99
71_V	97_L	0.613	0.99
147_A	151_A	0.611	0.99
93_I	98_S	0.609	0.99
242_M	246_Q	0.607	0.99
239_E	246_Q	0.606	0.99
6_I	54_L	0.606	0.99
94_S	240_I	0.605	0.99
30_D	33_Q	0.603	0.99
37_E	47_G	0.601	0.99
202_L	208_A	0.600	0.99
9_G	66_A	0.600	0.99
133_V	154_V	0.599	0.99
14_R	121_S	0.599	0.99
93_I	164_L	0.598	0.99
115_A	147_A	0.598	0.99
11_M	15_I	0.596	0.99
54_L	57_S	0.593	0.99
69_Y	72_K	0.593	0.99
211_P	214_E	0.593	0.99
58_S	61_I	0.593	0.99
235_R	239_E	0.588	0.99
29_Y	51_T	0.586	0.99
51_T	54_L	0.582	0.99
199_V	221_L	0.580	0.99
30_D	70_A	0.580	0.99
251_I	264_M	0.579	0.99
83_K	108_N	0.579	0.99
88_I	147_A	0.574	0.99
260_E	267_A	0.573	0.99
63_T	89_D	0.572	0.99
157_M	197_Q	0.572	0.99
61_I	85_K	0.571	0.99
8_L	16_A	0.569	0.99
75_V	101_L	0.564	0.99
146_I	149_E	0.564	0.99
46_N	57_S	0.564	0.99
78_L	81_L	0.562	0.98
60_V	143_V	0.559	0.98
71_V	101_L	0.559	0.98
36_I	39_F	0.557	0.98
195_P	221_L	0.557	0.98
123_F	126_Q	0.557	0.98
95_P	165_Y	0.554	0.98
224_D	227_T	0.549	0.98
212_T	216_K	0.548	0.98
162_M	165_Y	0.548	0.98
182_A	220_L	0.546	0.98
234_M	262_Y	0.543	0.98
138_D	142_I	0.542	0.98
62_I	150_T	0.541	0.98
254_V	257_L	0.541	0.98
152_S	204_T	0.541	0.98
186_N	250_I	0.538	0.98
137_K	144_N	0.534	0.98
51_T	78_L	0.534	0.98
52_K	55_V	0.533	0.98
36_I	49_Q	0.531	0.98
96_T	100_S	0.527	0.98
216_K	219_K	0.524	0.98
106_E	111_T	0.524	0.98
14_R	127_K	0.523	0.98
40_V	45_V	0.522	0.98
18_N	22_A	0.522	0.98
185_Y	217_A	0.521	0.98
238_L	262_Y	0.519	0.97
59_D	85_K	0.518	0.97
145_D	149_E	0.517	0.97
139_K	160_N	0.516	0.97
89_D	98_S	0.515	0.97
174_L	212_T	0.514	0.97
169_V	198_V	0.514	0.97
172_L	187_F	0.514	0.97
66_A	233_H	0.513	0.97
216_K	274_D	0.511	0.97
219_K	276_I	0.511	0.97
4_G	27_L	0.510	0.97
30_D	36_I	0.508	0.97
62_I	147_A	0.506	0.97
74_V	77_P	0.506	0.97
155_V	197_Q	0.505	0.97
216_K	220_L	0.504	0.97
130_V	206_S	0.504	0.97
207_S	212_T	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3dojA	3	0.9827	100	0.357	Contact Map
3zgyA	2	0.9758	100	0.357	Contact Map
3obbA	4	0.9792	100	0.359	Contact Map
3pefA	5	0.9758	100	0.361	Contact Map
3pduA	4	0.9758	100	0.361	Contact Map
3ckyA	4	0.9931	100	0.362	Contact Map
1vpdA	1	0.9931	100	0.365	Contact Map
4gbjA	2	0.9931	100	0.366	Contact Map
4oqzA	2	0.9723	100	0.368	Contact Map
3g0oA	3	0.9689	100	0.368	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0093 seconds.