GREMLIN Database
PYRH - Uridylate kinase
UniProt: Q97ZE2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 227 (206)
Sequences: 10522 (5730)
Seq/√Len: 399.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
148_K153_Y4.5971.00
3_N37_R3.7431.00
213_D218_E3.1351.00
144_G158_L2.6761.00
26_Q87_L2.5061.00
29_K33_D2.4691.00
128_A136_L2.4011.00
29_K89_Y2.3211.00
39_G131_S2.2361.00
90_M107_K2.2211.00
135_T201_I2.1531.00
165_Q194_E2.1461.00
147_E157_K2.1241.00
29_K87_L1.9891.00
89_Y108_V1.9771.00
10_G48_A1.9151.00
137_V203_M1.9091.00
12_F205_Y1.9081.00
22_I87_L1.8731.00
143_D207_K1.8361.00
30_E212_I1.8301.00
32_A89_Y1.8161.00
143_D204_N1.7891.00
81_M91_H1.7761.00
201_I214_I1.7581.00
147_E153_Y1.7541.00
168_R191_K1.7161.00
77_A111_T1.7161.00
148_K155_D1.7091.00
212_I216_K1.6741.00
129_E198_I1.6721.00
24_L80_V1.6471.00
32_A106_G1.6231.00
149_D152_I1.6181.00
125_A136_L1.5951.00
22_I86_D1.5891.00
167_L190_I1.5851.00
6_L28_I1.5731.00
23_V26_Q1.5711.00
141_N151_R1.5491.00
193_V200_V1.5331.00
47_T50_R1.5281.00
32_A37_R1.5121.00
140_T202_V1.5101.00
102_D107_K1.5071.00
125_A193_V1.4961.00
25_R83_S1.4851.00
42_T77_A1.4591.00
96_L100_I1.4441.00
42_T80_V1.4351.00
92_V107_K1.4211.00
143_D146_Y1.3971.00
23_V27_S1.3901.00
100_I104_S1.3821.00
30_E33_D1.3741.00
5_I133_S1.3571.00
147_E159_I1.3531.00
27_S209_N1.3121.00
32_A108_V1.3121.00
22_I83_S1.3081.00
20_N23_V1.2971.00
98_E102_D1.2941.00
34_N216_K1.2601.00
21_L80_V1.2581.00
129_E196_S1.2501.00
99_F111_T1.2371.00
28_I40_I1.2181.00
203_M210_R1.2141.00
48_A51_Y1.1981.00
84_L91_H1.1861.00
207_K213_D1.1851.00
101_Q104_S1.1811.00
96_L132_S1.1811.00
204_N207_K1.1801.00
26_Q29_K1.1731.00
166_D173_G1.1691.00
145_V162_L1.1611.00
207_K210_R1.1591.00
30_E209_N1.1591.00
101_Q105_H1.1551.00
92_V102_D1.1491.00
150_P156_V1.1461.00
46_S50_R1.1391.00
30_E34_N1.1361.00
124_A136_L1.1211.00
83_S87_L1.1201.00
210_R213_D1.1191.00
65_L69_G1.1041.00
22_I26_Q1.0991.00
148_K156_V1.0841.00
74_R77_A1.0841.00
21_L83_S1.0761.00
27_S208_L1.0741.00
102_D109_V1.0721.00
37_R106_G1.0651.00
147_E156_V1.0631.00
143_D158_L1.0621.00
4_I36_F1.0601.00
47_T115_Q1.0581.00
20_N206_R1.0571.00
30_E208_L1.0511.00
203_M214_I1.0451.00
122_A192_I1.0421.00
132_S196_S1.0361.00
39_G103_W1.0321.00
211_I214_I1.0211.00
111_T114_F1.0211.00
3_N100_I1.0181.00
191_K195_R1.0091.00
70_I92_V1.0041.00
165_Q169_K1.0031.00
37_R104_S0.9911.00
28_I108_V0.9891.00
48_A52_I0.9871.00
38_V42_T0.9801.00
84_L89_Y0.9791.00
158_L204_N0.9771.00
146_Y156_V0.9671.00
212_I215_L0.9671.00
26_Q30_E0.9611.00
18_V22_I0.9571.00
71_W75_L0.9571.00
26_Q208_L0.9541.00
11_K45_G0.9391.00
29_K84_L0.9371.00
11_K14_D0.9281.00
167_L170_I0.9271.00
31_L34_N0.9191.00
44_G72_A0.9181.00
145_V202_V0.9181.00
137_V201_I0.9131.00
25_R84_L0.9091.00
94_Q98_E0.9061.00
159_I162_L0.9011.00
94_Q97_E0.8941.00
31_L36_F0.8891.00
148_K154_A0.8861.00
85_Q90_M0.8831.00
29_K32_A0.8751.00
122_A188_L0.8741.00
19_D22_I0.8731.00
83_S86_D0.8691.00
3_N134_K0.8681.00
209_N213_D0.8671.00
164_T190_I0.8661.00
99_F103_W0.8631.00
139_A203_M0.8631.00
128_A198_I0.8591.00
161_H216_K0.8581.00
32_A38_V0.8551.00
15_E19_D0.8541.00
21_L79_L0.8531.00
78_Y82_F0.8531.00
8_I40_I0.8431.00
135_T199_R0.8341.00
138_V141_N0.8321.00
125_A192_I0.8251.00
146_Y150_P0.8211.00
165_Q168_R0.8211.00
181_T194_E0.8201.00
46_S183_E0.8151.00
60_I65_L0.8151.00
6_L31_L0.8131.00
100_I132_S0.8131.00
29_K108_V0.8071.00
25_R87_L0.8061.00
143_D210_R0.8051.00
15_E20_N0.7961.00
197_K217_G0.7941.00
52_I56_R0.7921.00
146_Y158_L0.7911.00
137_V211_I0.7841.00
136_L193_V0.7791.00
50_R54_L0.7771.00
145_V159_I0.7751.00
93_P96_L0.7751.00
31_L137_V0.7721.00
92_V109_V0.7721.00
31_L38_V0.7711.00
8_I12_F0.7711.00
127_V131_S0.7681.00
31_L215_L0.7661.00
28_I84_L0.7661.00
209_N212_I0.7651.00
82_F85_Q0.7641.00
6_L137_V0.7621.00
25_R80_V0.7591.00
163_T166_D0.7461.00
152_I183_E0.7421.00
95_S98_E0.7421.00
167_L171_L0.7381.00
53_K81_M0.7371.00
159_I173_G0.7371.00
106_G109_V0.7361.00
15_E18_V0.7291.00
188_L191_K0.7261.00
194_E200_V0.7261.00
95_S102_D0.7251.00
95_S99_F0.7241.00
28_I38_V0.7241.00
46_S49_R0.7201.00
66_D114_F0.7181.00
193_V198_I0.7161.00
97_E101_Q0.7161.00
63_A67_L0.7131.00
23_V205_Y0.7091.00
82_F86_D0.7071.00
188_L192_I0.7071.00
118_Q189_A0.7071.00
4_I135_T0.7041.00
68_L79_L0.7011.00
64_Y101_Q0.6981.00
53_K57_E0.6951.00
166_D169_K0.6850.99
27_S30_E0.6850.99
55_A65_L0.6830.99
68_L71_W0.6820.99
12_F141_N0.6810.99
23_V208_L0.6810.99
39_G42_T0.6800.99
169_K173_G0.6770.99
11_K141_N0.6750.99
45_G50_R0.6750.99
34_N212_I0.6700.99
160_P211_I0.6690.99
49_R52_I0.6680.99
98_E101_Q0.6670.99
33_D89_Y0.6610.99
81_M85_Q0.6610.99
149_D156_V0.6590.99
3_N6_L0.6590.99
109_V112_G0.6570.99
189_A193_V0.6570.99
192_I196_S0.6520.99
172_E187_P0.6510.99
95_S130_A0.6500.99
113_G116_P0.6500.99
24_L28_I0.6490.99
211_I215_L0.6470.99
102_D105_H0.6460.99
25_R29_K0.6450.99
53_K56_R0.6440.99
84_L108_V0.6430.99
168_R172_E0.6410.99
36_F134_K0.6410.99
88_A91_H0.6390.99
40_I80_V0.6380.99
4_I215_L0.6340.99
170_I173_G0.6310.99
169_K172_E0.6230.99
39_G127_V0.6220.99
103_W109_V0.6210.99
90_M106_G0.6200.99
140_T200_V0.6190.99
8_I13_F0.6150.99
51_Y55_A0.6140.99
185_L189_A0.6120.99
39_G133_S0.6100.99
168_R171_L0.6090.99
185_L200_V0.6070.99
157_K161_H0.6010.99
213_D216_K0.5970.99
153_Y156_V0.5970.99
4_I38_V0.5960.99
68_L75_L0.5950.99
129_E192_I0.5920.99
26_Q86_D0.5870.98
94_Q103_W0.5860.98
21_L25_R0.5860.98
11_K140_T0.5860.98
79_L82_F0.5850.98
85_Q91_H0.5840.98
95_S101_Q0.5810.98
81_M97_E0.5810.98
167_L172_E0.5800.98
99_F130_A0.5720.98
49_R117_G0.5710.98
59_G62_E0.5710.98
185_L202_V0.5690.98
6_L38_V0.5660.98
20_N24_L0.5650.98
60_I64_Y0.5630.98
114_F119_S0.5630.98
96_L130_A0.5580.98
168_R187_P0.5540.98
45_G183_E0.5520.98
84_L87_L0.5480.98
99_F109_V0.5450.98
141_N150_P0.5440.97
27_S207_K0.5430.97
38_V108_V0.5360.97
167_L173_G0.5310.97
158_L210_R0.5290.97
190_I200_V0.5270.97
50_R53_K0.5270.97
26_Q33_D0.5220.97
146_Y185_L0.5210.97
20_N205_Y0.5170.97
52_I69_G0.5140.96
208_L212_I0.5130.96
45_G49_R0.5120.96
14_D48_A0.5110.96
52_I65_L0.5080.96
85_Q92_V0.5070.96
6_L139_A0.5060.96
135_T214_I0.5060.96
115_Q119_S0.5030.96
142_V146_Y0.5020.96
68_L78_Y0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4q1tA 4 0.9163 100 0.24 Contact Map
2j5vA 2 0.8282 100 0.256 Contact Map
3ab4A 7 0.9515 100 0.265 Contact Map
3l76A 2 0.9515 100 0.266 Contact Map
2brxA 5 0.9515 100 0.278 Contact Map
2j4jA 5 0.9912 100 0.282 Contact Map
2akoA 2 0.9383 100 0.292 Contact Map
3c1mA 3 0.9515 100 0.293 Contact Map
2j0wA 2 0.9427 100 0.301 Contact Map
3nwyA 5 0.9427 100 0.306 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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