HOSA - SULSO - GREMLIN Contacts

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HOSA - Putative homocitrate synthase

UniProt:	Q97ZE0	Sequences: MIKVGILDSTLREGEQTPGVIFTVDQRVEIAKALSDLGVSMIEAGHPAVSPDIYEGIKRIVKLKKEGIITSEIVGHSRAVKRDIEIAAELEVDRIAIFYGVSDIHLKAKHKATREEALRVIAETISYARSHGVKVRFTAEDGSRTDFDFLVTVSRTARDAGADRVSIADTVGILYPSKTKELFSALIREVPNLEYDIHAHNDLGLAVANALAAVEGGATIVHATVNGLGERVGIVPLQQIVAAIKYHFGIEVVKLDKLQYVSSLIEKYSGIPMPPNYPITGDYAFLHKAGVHVAGVLSDPRTYEFMPPETFGRTRDYTIDKYTGKHALRDKYEKLGVKISEAEMDQILAKIKSNTTIRFYRDVDLLELAEEVTGRVLKPRPPEQIEALISVKCDSNVYTTSVTRRLSVINGVKEVMEISGDYDILVKVQAKDSNELNQIIESIRATKGVRSTLTSLVLKKM	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	461 (439)
Sequences:	5143 (2621)
Seq/√Len:	125.1

ECOLI - LEU1 HOA
BACSU - LEU1
SULSO - HOSA Q980Z1 LEU1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
85_E	127_Y	4.131	1.00
294_A	298_S	3.906	1.00
47_P	75_G	3.710	1.00
180_K	216_G	3.487	1.00
113_T	116_E	3.377	1.00
103_D	114_R	3.224	1.00
119_R	123_E	3.190	1.00
197_I	213_A	3.115	1.00
187_I	195_Y	3.050	1.00
381_P	406_L	2.893	1.00
121_I	153_V	2.833	1.00
154_S	165_V	2.808	1.00
35_S	71_S	2.807	1.00
177_S	215_E	2.765	1.00
129_R	163_D	2.726	1.00
81_K	123_E	2.700	1.00
184_S	188_R	2.641	1.00
103_D	146_D	2.639	1.00
147_F	185_A	2.572	1.00
115_E	152_T	2.569	1.00
122_A	160_A	2.502	1.00
35_S	70_T	2.492	1.00
199_A	210_A	2.450	1.00
122_A	126_S	2.449	1.00
51_P	55_E	2.431	1.00
121_I	157_A	2.399	1.00
333_E	338_K	2.374	1.00
307_P	310_T	2.371	1.00
101_V	145_T	2.361	1.00
112_A	120_V	2.349	1.00
383_E	406_L	2.335	1.00
37_L	261_V	2.236	1.00
106_L	114_R	2.209	1.00
108_A	299_D	2.202	1.00
414_E	431_K	2.202	1.00
59_R	63_L	2.195	1.00
257_K	260_Y	2.164	1.00
214_V	221_V	2.159	1.00
204_G	239_Q	2.137	1.00
33_A	36_D	2.133	1.00
167_I	186_L	2.126	1.00
81_K	127_Y	2.084	1.00
58_K	62_K	2.058	1.00
226_N	262_S	2.011	1.00
114_R	152_T	2.000	1.00
109_K	140_E	1.994	1.00
241_V	253_V	1.981	1.00
185_A	189_E	1.977	1.00
122_A	156_T	1.976	1.00
36_D	257_K	1.968	1.00
81_K	85_E	1.911	1.00
114_R	149_F	1.902	1.00
210_A	221_V	1.900	1.00
115_E	119_R	1.883	1.00
262_S	273_M	1.859	1.00
29_E	267_K	1.852	1.00
33_A	264_L	1.840	1.00
84_I	124_T	1.837	1.00
235_V	240_I	1.832	1.00
406_L	409_I	1.824	1.00
340_S	343_E	1.820	1.00
118_L	153_V	1.814	1.00
106_L	117_A	1.814	1.00
332_Y	369_A	1.775	1.00
180_K	215_E	1.775	1.00
383_E	411_G	1.766	1.00
112_A	116_E	1.750	1.00
167_I	182_L	1.738	1.00
404_R	411_G	1.720	1.00
118_L	152_T	1.710	1.00
184_S	216_G	1.698	1.00
125_I	135_V	1.695	1.00
32_K	63_L	1.695	1.00
75_G	87_A	1.676	1.00
254_K	257_K	1.673	1.00
353_S	357_I	1.671	1.00
156_T	159_D	1.645	1.00
85_E	131_H	1.643	1.00
151_V	185_A	1.641	1.00
194_E	219_T	1.637	1.00
239_Q	277_Y	1.634	1.00
30_I	265_I	1.626	1.00
195_Y	218_A	1.625	1.00
24_V	59_R	1.614	1.00
404_R	413_K	1.611	1.00
114_R	146_D	1.608	1.00
328_L	347_I	1.597	1.00
6_I	39_V	1.593	1.00
406_L	411_G	1.585	1.00
55_E	59_R	1.578	1.00
85_E	89_E	1.561	1.00
180_K	184_S	1.561	1.00
296_V	316_D	1.523	1.00
155_R	189_E	1.514	1.00
22_F	269_S	1.511	1.00
241_V	255_L	1.492	1.00
419_S	423_D	1.489	1.00
330_D	333_E	1.489	1.00
350_K	353_S	1.488	1.00
259_Q	313_R	1.485	1.00
101_V	153_V	1.483	1.00
69_I	91_E	1.483	1.00
288_K	320_D	1.482	1.00
169_D	209_N	1.473	1.00
179_T	197_I	1.468	1.00
106_L	146_D	1.468	1.00
137_F	153_V	1.457	1.00
127_Y	131_H	1.448	1.00
122_A	159_D	1.448	1.00
116_E	119_R	1.444	1.00
59_R	62_K	1.443	1.00
331_K	362_D	1.428	1.00
106_L	145_T	1.426	1.00
349_A	353_S	1.407	1.00
103_D	107_K	1.404	1.00
174_L	179_T	1.397	1.00
125_I	160_A	1.391	1.00
139_A	154_S	1.379	1.00
151_V	155_R	1.372	1.00
329_R	333_E	1.365	1.00
402_V	415_V	1.364	1.00
288_K	322_Y	1.364	1.00
33_A	261_V	1.363	1.00
242_A	255_L	1.358	1.00
304_E	315_R	1.356	1.00
350_K	371_E	1.354	1.00
47_P	57_I	1.352	1.00
378_K	381_P	1.349	1.00
329_R	341_E	1.343	1.00
183_F	195_Y	1.343	1.00
210_A	240_I	1.335	1.00
379_P	408_V	1.333	1.00
39_V	253_V	1.330	1.00
383_E	404_R	1.316	1.00
183_F	216_G	1.316	1.00
52_D	356_T	1.315	1.00
122_A	157_A	1.309	1.00
144_R	173_I	1.300	1.00
348_L	352_K	1.298	1.00
115_E	118_L	1.293	1.00
154_S	167_I	1.292	1.00
144_R	178_K	1.292	1.00
407_S	410_N	1.291	1.00
148_D	151_V	1.287	1.00
86_I	89_E	1.286	1.00
183_F	197_I	1.283	1.00
6_I	241_V	1.282	1.00
350_K	372_V	1.282	1.00
112_A	117_A	1.281	1.00
55_E	58_K	1.280	1.00
181_E	185_A	1.271	1.00
158_R	193_L	1.269	1.00
158_R	165_V	1.267	1.00
437_N	441_E	1.265	1.00
151_V	186_L	1.261	1.00
54_Y	86_I	1.258	1.00
98_F	291_V	1.255	1.00
187_I	219_T	1.252	1.00
103_D	106_L	1.249	1.00
400_T	415_V	1.248	1.00
106_L	149_F	1.247	1.00
285_F	311_F	1.243	1.00
143_S	174_L	1.228	0.99
31_A	56_G	1.227	0.99
358_R	364_D	1.224	0.99
211_L	243_A	1.215	0.99
207_V	240_I	1.209	0.99
88_A	132_G	1.193	0.99
264_L	268_Y	1.171	0.99
331_K	334_K	1.170	0.99
118_L	156_T	1.168	0.99
88_A	131_H	1.160	0.99
99_Y	137_F	1.158	0.99
223_A	241_V	1.153	0.99
325_K	345_D	1.152	0.99
25_D	59_R	1.151	0.99
225_V	265_I	1.150	0.99
212_A	216_G	1.147	0.99
201_N	204_G	1.147	0.99
140_E	303_Y	1.143	0.99
201_N	278_P	1.140	0.99
416_M	427_K	1.135	0.99
155_R	159_D	1.133	0.99
134_K	163_D	1.129	0.99
366_L	370_E	1.128	0.99
210_A	235_V	1.120	0.99
105_H	141_D	1.120	0.99
148_D	152_T	1.118	0.99
100_G	141_D	1.118	0.99
380_R	407_S	1.113	0.99
245_K	251_E	1.110	0.99
121_I	156_T	1.109	0.99
36_D	260_Y	1.108	0.99
403_T	414_E	1.106	0.99
100_G	105_H	1.105	0.99
41_M	134_K	1.101	0.99
22_F	268_Y	1.100	0.99
72_E	134_K	1.090	0.99
347_I	368_L	1.086	0.99
13_E	234_I	1.086	0.99
60_I	73_I	1.081	0.99
332_Y	339_I	1.070	0.99
183_F	186_L	1.068	0.99
44_A	57_I	1.068	0.99
223_A	237_L	1.067	0.98
155_R	158_R	1.067	0.98
156_T	160_A	1.067	0.98
110_H	140_E	1.064	0.98
201_N	206_A	1.059	0.98
414_E	432_D	1.050	0.98
104_I	108_A	1.047	0.98
40_S	70_T	1.042	0.98
126_S	160_A	1.035	0.98
155_R	190_V	1.032	0.98
33_A	260_Y	1.024	0.98
151_V	189_E	1.017	0.98
147_F	182_L	1.016	0.98
239_Q	278_P	1.014	0.98
259_Q	263_S	1.011	0.98
118_L	149_F	1.011	0.98
386_E	400_T	1.010	0.98
175_Y	248_F	1.008	0.98
22_F	30_I	1.006	0.98
138_T	168_A	1.004	0.98
152_T	156_T	1.004	0.98
141_D	144_R	1.001	0.98
245_K	310_T	1.000	0.98
434_N	441_E	1.000	0.98
51_P	86_I	0.998	0.98
17_T	20_V	0.995	0.98
415_V	431_K	0.991	0.98
110_H	303_Y	0.989	0.98
330_D	334_K	0.987	0.97
48_A	82_R	0.986	0.97
72_E	92_V	0.986	0.97
79_A	124_T	0.985	0.97
64_K	69_I	0.984	0.97
131_H	134_K	0.980	0.97
109_K	303_Y	0.979	0.97
346_Q	372_V	0.971	0.97
28_V	59_R	0.957	0.97
438_Q	441_E	0.956	0.97
210_A	223_A	0.953	0.97
33_A	257_K	0.951	0.97
433_S	436_L	0.951	0.97
149_F	153_V	0.950	0.97
109_K	294_A	0.947	0.97
423_D	427_K	0.947	0.97
57_I	75_G	0.945	0.97
185_A	188_R	0.941	0.97
123_E	127_Y	0.941	0.97
379_P	407_S	0.940	0.97
329_R	344_M	0.940	0.97
136_R	196_D	0.940	0.97
111_K	298_S	0.938	0.97
96_A	138_T	0.930	0.96
77_S	87_A	0.927	0.96
445_A	449_V	0.927	0.96
447_K	452_T	0.925	0.96
148_D	185_A	0.924	0.96
100_G	140_E	0.918	0.96
78_R	83_D	0.913	0.96
177_S	181_E	0.908	0.96
7_L	96_A	0.907	0.96
394_D	400_T	0.907	0.96
52_D	321_K	0.905	0.96
72_E	93_D	0.904	0.96
211_L	248_F	0.899	0.96
207_V	210_A	0.898	0.96
386_E	402_V	0.898	0.96
339_I	347_I	0.895	0.96
210_A	214_V	0.891	0.95
384_Q	404_R	0.889	0.95
79_A	97_I	0.887	0.95
181_E	184_S	0.887	0.95
127_Y	130_S	0.884	0.95
204_G	278_P	0.882	0.95
175_Y	215_E	0.882	0.95
204_G	236_P	0.880	0.95
413_K	417_E	0.879	0.95
212_A	215_E	0.877	0.95
412_V	432_D	0.874	0.95
23_T	26_Q	0.872	0.95
92_V	133_V	0.871	0.95
74_V	94_R	0.870	0.95
354_N	368_L	0.869	0.95
437_N	440_I	0.869	0.95
143_S	182_L	0.867	0.95
20_V	228_L	0.861	0.95
398_Y	402_V	0.857	0.94
207_V	235_V	0.847	0.94
153_V	157_A	0.846	0.94
88_A	93_D	0.846	0.94
228_L	271_I	0.843	0.94
426_V	430_A	0.843	0.94
20_V	30_I	0.840	0.94
341_E	344_M	0.833	0.93
293_V	327_A	0.833	0.93
35_S	69_I	0.830	0.93
341_E	345_D	0.830	0.93
177_S	180_K	0.824	0.93
103_D	145_T	0.824	0.93
207_V	239_Q	0.823	0.93
180_K	212_A	0.822	0.93
76_H	138_T	0.822	0.93
363_V	367_E	0.820	0.93
128_A	135_V	0.817	0.93
28_V	32_K	0.814	0.93
345_D	349_A	0.813	0.93
28_V	63_L	0.809	0.92
96_A	166_S	0.809	0.92
139_A	150_L	0.807	0.92
335_L	362_D	0.807	0.92
30_I	34_L	0.803	0.92
109_K	302_T	0.803	0.92
49_V	322_Y	0.801	0.92
205_L	211_L	0.798	0.92
425_L	429_Q	0.792	0.92
157_A	162_A	0.791	0.92
18_P	283_Y	0.788	0.91
328_L	365_L	0.788	0.91
179_T	183_F	0.787	0.91
139_A	167_I	0.784	0.91
263_S	267_K	0.783	0.91
199_A	213_A	0.781	0.91
54_Y	90_L	0.778	0.91
57_I	73_I	0.778	0.91
9_S	105_H	0.776	0.91
318_T	322_Y	0.775	0.91
39_V	241_V	0.774	0.91
126_S	130_S	0.774	0.91
125_I	157_A	0.772	0.91
158_R	192_N	0.771	0.91
179_T	199_A	0.769	0.90
245_K	252_V	0.769	0.90
404_R	417_E	0.768	0.90
400_T	417_E	0.767	0.90
24_V	56_G	0.767	0.90
440_I	443_I	0.765	0.90
346_Q	349_A	0.764	0.90
148_D	189_E	0.764	0.90
380_R	405_R	0.762	0.90
225_V	261_V	0.759	0.90
186_L	190_V	0.758	0.90
136_R	222_H	0.758	0.90
106_L	112_A	0.755	0.90
219_T	250_I	0.754	0.90
262_S	280_T	0.750	0.89
42_I	71_S	0.747	0.89
97_I	161_G	0.747	0.89
242_A	279_I	0.747	0.89
119_R	122_A	0.747	0.89
177_S	212_A	0.746	0.89
20_V	271_I	0.746	0.89
136_R	166_S	0.745	0.89
309_E	314_T	0.745	0.89
15_E	22_F	0.744	0.89
96_A	136_R	0.744	0.89
63_L	69_I	0.741	0.89
205_L	243_A	0.740	0.89
107_K	111_K	0.739	0.89
407_S	412_V	0.739	0.89
328_L	348_L	0.738	0.89
31_A	60_I	0.736	0.88
186_L	195_Y	0.734	0.88
88_A	133_V	0.733	0.88
428_V	432_D	0.732	0.88
236_P	239_Q	0.729	0.88
394_D	397_V	0.727	0.88
118_L	122_A	0.726	0.88
430_A	437_N	0.723	0.88
134_K	164_R	0.722	0.87
343_E	346_Q	0.719	0.87
419_S	450_R	0.716	0.87
46_H	291_V	0.716	0.87
433_S	440_I	0.716	0.87
402_V	413_K	0.714	0.87
214_V	250_I	0.713	0.87
433_S	438_Q	0.708	0.86
370_E	375_R	0.708	0.86
425_L	428_V	0.708	0.86
123_E	126_S	0.707	0.86
44_A	73_I	0.706	0.86
354_N	357_I	0.706	0.86
17_T	271_I	0.704	0.86
339_I	369_A	0.703	0.86
236_P	277_Y	0.700	0.86
433_S	437_N	0.699	0.86
449_V	454_T	0.698	0.86
238_Q	277_Y	0.696	0.86
97_I	124_T	0.695	0.85
242_A	306_M	0.691	0.85
46_H	76_H	0.690	0.85
31_A	35_S	0.690	0.85
136_R	220_I	0.688	0.85
347_I	369_A	0.688	0.85
266_E	272_P	0.687	0.85
297_L	330_D	0.687	0.85
394_D	415_V	0.685	0.85
100_G	110_H	0.684	0.85
17_T	228_L	0.684	0.85
408_V	412_V	0.683	0.84
360_Y	364_D	0.682	0.84
113_T	119_R	0.682	0.84
430_A	450_R	0.682	0.84
17_T	276_N	0.680	0.84
164_R	194_E	0.679	0.84
367_E	371_E	0.679	0.84
228_L	269_S	0.678	0.84
412_V	431_K	0.674	0.84
40_S	253_V	0.673	0.84
382_P	385_I	0.673	0.84
28_V	60_I	0.671	0.83
102_S	105_H	0.670	0.83
76_H	166_S	0.668	0.83
332_Y	365_L	0.667	0.83
154_S	190_V	0.666	0.83
160_A	163_D	0.665	0.83
12_R	16_Q	0.665	0.83
271_I	274_P	0.662	0.83
104_I	302_T	0.662	0.83
242_A	310_T	0.660	0.82
143_S	167_I	0.660	0.82
25_D	29_E	0.659	0.82
138_T	166_S	0.659	0.82
116_E	120_V	0.658	0.82
37_L	258_L	0.658	0.82
174_L	178_K	0.658	0.82
274_P	278_P	0.656	0.82
154_S	186_L	0.656	0.82
41_M	74_V	0.656	0.82
288_K	321_K	0.653	0.82
98_F	138_T	0.652	0.82
120_V	124_T	0.651	0.82
436_L	441_E	0.651	0.82
169_D	179_T	0.650	0.81
361_R	364_D	0.649	0.81
26_Q	270_G	0.648	0.81
167_I	183_F	0.646	0.81
215_E	248_F	0.646	0.81
309_E	315_R	0.645	0.81
48_A	86_I	0.644	0.81
346_Q	350_K	0.642	0.81
261_V	265_I	0.642	0.81
100_G	109_K	0.642	0.81
35_S	73_I	0.640	0.80
51_P	353_S	0.637	0.80
243_A	279_I	0.636	0.80
398_Y	417_E	0.635	0.80
328_L	344_M	0.635	0.80
196_D	222_H	0.634	0.80
164_R	220_I	0.633	0.80
225_V	238_Q	0.631	0.79
197_I	214_V	0.631	0.79
143_S	179_T	0.631	0.79
434_N	438_Q	0.631	0.79
9_S	13_E	0.630	0.79
214_V	244_I	0.630	0.79
386_E	415_V	0.630	0.79
100_G	138_T	0.630	0.79
80_V	120_V	0.629	0.79
45_G	57_I	0.628	0.79
107_K	113_T	0.628	0.79
436_L	440_I	0.626	0.79
20_V	270_G	0.626	0.79
49_V	321_K	0.625	0.79
421_D	425_L	0.624	0.79
140_E	292_H	0.624	0.79
28_V	56_G	0.622	0.79
347_I	373_T	0.620	0.78
326_H	330_D	0.619	0.78
431_K	434_N	0.618	0.78
384_Q	398_Y	0.617	0.78
6_I	210_A	0.617	0.78
275_P	282_D	0.615	0.78
274_P	277_Y	0.615	0.78
97_I	125_I	0.614	0.78
265_I	269_S	0.614	0.78
182_L	186_L	0.614	0.78
76_H	81_K	0.613	0.78
114_R	145_T	0.612	0.77
102_S	141_D	0.612	0.77
173_I	305_F	0.612	0.77
155_R	193_L	0.611	0.77
151_V	190_V	0.611	0.77
364_D	367_E	0.609	0.77
407_S	432_D	0.608	0.77
293_V	323_T	0.606	0.77
7_L	222_H	0.606	0.77
354_N	360_Y	0.605	0.77
419_S	444_R	0.604	0.76
178_K	247_H	0.604	0.76
416_M	431_K	0.604	0.76
94_R	134_K	0.603	0.76
29_E	268_Y	0.602	0.76
446_T	453_L	0.601	0.76
7_L	74_V	0.601	0.76
394_D	398_Y	0.601	0.76
26_Q	358_R	0.601	0.76
38_G	70_T	0.601	0.76
13_E	16_Q	0.601	0.76
101_V	139_A	0.600	0.76
165_V	195_Y	0.599	0.76
120_V	123_E	0.598	0.76
54_Y	89_E	0.597	0.76
350_K	354_N	0.597	0.76
100_G	103_D	0.596	0.76
60_I	63_L	0.596	0.76
275_P	283_Y	0.595	0.75
439_I	442_S	0.594	0.75
434_N	437_N	0.594	0.75
129_R	133_V	0.593	0.75
37_L	241_V	0.593	0.75
447_K	450_R	0.593	0.75
402_V	417_E	0.591	0.75
29_E	264_L	0.591	0.75
152_T	155_R	0.590	0.75
115_E	149_F	0.590	0.75
73_I	76_H	0.588	0.75
20_V	268_Y	0.587	0.74
87_A	95_I	0.586	0.74
75_G	92_V	0.586	0.74
6_I	252_V	0.585	0.74
95_I	132_G	0.585	0.74
263_S	282_D	0.585	0.74
407_S	436_L	0.583	0.74
199_A	235_V	0.583	0.74
105_H	144_R	0.580	0.74
287_H	292_H	0.580	0.74
414_E	417_E	0.579	0.73
237_L	258_L	0.579	0.73
100_G	137_F	0.577	0.73
9_S	125_I	0.577	0.73
99_Y	110_H	0.576	0.73
98_F	137_F	0.575	0.73
130_S	133_V	0.574	0.73
147_F	181_E	0.573	0.73
398_Y	413_K	0.572	0.73
9_S	141_D	0.572	0.73
422_Y	439_I	0.571	0.72
97_I	128_A	0.571	0.72
332_Y	335_L	0.570	0.72
104_I	301_R	0.570	0.72
15_E	322_Y	0.570	0.72
405_R	414_E	0.569	0.72
98_F	352_K	0.569	0.72
153_V	156_T	0.567	0.72
427_K	431_K	0.561	0.71
34_L	42_I	0.561	0.71
398_Y	404_R	0.561	0.71
412_V	434_N	0.560	0.71
335_L	366_L	0.559	0.71
46_H	50_S	0.559	0.71
201_N	274_P	0.559	0.71
224_T	237_L	0.555	0.70
238_Q	242_A	0.555	0.70
157_A	165_V	0.555	0.70
54_Y	57_I	0.555	0.70
164_R	219_T	0.554	0.70
256_D	310_T	0.554	0.70
385_I	399_T	0.553	0.70
428_V	431_K	0.552	0.70
143_S	173_I	0.551	0.70
169_D	172_G	0.551	0.70
406_L	410_N	0.550	0.70
100_G	117_A	0.550	0.70
261_V	264_L	0.550	0.70
32_K	36_D	0.550	0.70
111_K	294_A	0.549	0.69
122_A	153_V	0.548	0.69
342_A	345_D	0.547	0.69
313_R	316_D	0.547	0.69
99_Y	117_A	0.546	0.69
287_H	304_E	0.545	0.69
403_T	425_L	0.545	0.69
76_H	98_F	0.543	0.69
54_Y	58_K	0.542	0.68
166_S	222_H	0.542	0.68
109_K	295_G	0.542	0.68
447_K	453_L	0.542	0.68
426_V	437_N	0.539	0.68
292_H	303_Y	0.538	0.68
190_V	195_Y	0.538	0.68
203_L	305_F	0.536	0.68
105_H	302_T	0.536	0.68
77_S	98_F	0.535	0.68
15_E	321_K	0.535	0.68
245_K	253_V	0.535	0.68
339_I	344_M	0.534	0.67
399_T	403_T	0.534	0.67
29_E	260_Y	0.534	0.67
402_V	414_E	0.533	0.67
8_D	11_L	0.533	0.67
294_A	327_A	0.532	0.67
57_I	61_V	0.532	0.67
69_I	92_V	0.531	0.67
17_T	22_F	0.531	0.67
124_T	157_A	0.530	0.67
20_V	265_I	0.530	0.67
387_A	421_D	0.529	0.67
411_G	415_V	0.529	0.67
6_I	223_A	0.528	0.66
226_N	273_M	0.528	0.66
395_S	398_Y	0.528	0.66
384_Q	394_D	0.528	0.66
183_F	218_A	0.528	0.66
106_L	113_T	0.527	0.66
291_V	302_T	0.527	0.66
331_K	365_L	0.527	0.66
167_I	179_T	0.526	0.66
24_V	28_V	0.525	0.66
226_N	265_I	0.525	0.66
100_G	145_T	0.524	0.66
154_S	182_L	0.523	0.66
79_A	83_D	0.523	0.66
273_M	280_T	0.523	0.66
386_E	413_K	0.523	0.66
351_I	365_L	0.521	0.65
354_N	364_D	0.520	0.65
179_T	213_A	0.519	0.65
298_S	329_R	0.517	0.65
101_V	138_T	0.516	0.65
84_I	127_Y	0.516	0.65
7_L	220_I	0.516	0.65
103_D	149_F	0.516	0.65
30_I	334_K	0.516	0.65
22_F	265_I	0.516	0.65
405_R	412_V	0.514	0.64
129_R	162_A	0.514	0.64
400_T	413_K	0.513	0.64
295_G	303_Y	0.513	0.64
321_K	352_K	0.512	0.64
332_Y	337_V	0.512	0.64
399_T	432_D	0.512	0.64
449_V	452_T	0.510	0.64
207_V	223_A	0.510	0.64
258_L	316_D	0.510	0.64
95_I	133_V	0.510	0.64
380_R	433_S	0.510	0.64
412_V	436_L	0.509	0.64
300_P	315_R	0.509	0.64
308_P	316_D	0.509	0.64
411_G	417_E	0.507	0.63
172_G	209_N	0.507	0.63
393_C	396_N	0.506	0.63
380_R	432_D	0.506	0.63
110_H	137_F	0.506	0.63
13_E	27_R	0.504	0.63
121_I	126_S	0.504	0.63
386_E	394_D	0.503	0.63
114_R	148_D	0.502	0.63
166_S	196_D	0.502	0.63
433_S	441_E	0.501	0.62
408_V	411_G	0.501	0.62
61_V	91_E	0.501	0.62
125_I	162_A	0.501	0.62
242_A	258_L	0.500	0.62
365_L	369_A	0.500	0.62

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3hq1A	2	0.9653	100	0.209	Contact Map
4ov4A	2	0.7787	100	0.286	Contact Map
2ztjA	2	0.6616	100	0.292	Contact Map
3ivsA	2	0.7636	100	0.312	Contact Map
3rmjA	2	0.6443	100	0.319	Contact Map
3bleA	2	0.6508	100	0.404	Contact Map
3eegA	2	0.5683	100	0.447	Contact Map
2qf7A	4	0.9414	100	0.509	Contact Map
4qshA	4	0.885	100	0.521	Contact Map
2cw6A	5	0.5965	100	0.526	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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