GREMLIN Database
HOSA - Putative homocitrate synthase
UniProt: Q97ZE0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 461 (439)
Sequences: 5143 (2621)
Seq/√Len: 125.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
85_E127_Y4.1311.00
294_A298_S3.9061.00
47_P75_G3.7101.00
180_K216_G3.4871.00
113_T116_E3.3771.00
103_D114_R3.2241.00
119_R123_E3.1901.00
197_I213_A3.1151.00
187_I195_Y3.0501.00
381_P406_L2.8931.00
121_I153_V2.8331.00
154_S165_V2.8081.00
35_S71_S2.8071.00
177_S215_E2.7651.00
129_R163_D2.7261.00
81_K123_E2.7001.00
184_S188_R2.6411.00
103_D146_D2.6391.00
147_F185_A2.5721.00
115_E152_T2.5691.00
122_A160_A2.5021.00
35_S70_T2.4921.00
199_A210_A2.4501.00
122_A126_S2.4491.00
51_P55_E2.4311.00
121_I157_A2.3991.00
333_E338_K2.3741.00
307_P310_T2.3711.00
101_V145_T2.3611.00
112_A120_V2.3491.00
383_E406_L2.3351.00
37_L261_V2.2361.00
106_L114_R2.2091.00
108_A299_D2.2021.00
414_E431_K2.2021.00
59_R63_L2.1951.00
257_K260_Y2.1641.00
214_V221_V2.1591.00
204_G239_Q2.1371.00
33_A36_D2.1331.00
167_I186_L2.1261.00
81_K127_Y2.0841.00
58_K62_K2.0581.00
226_N262_S2.0111.00
114_R152_T2.0001.00
109_K140_E1.9941.00
241_V253_V1.9811.00
185_A189_E1.9771.00
122_A156_T1.9761.00
36_D257_K1.9681.00
81_K85_E1.9111.00
114_R149_F1.9021.00
210_A221_V1.9001.00
115_E119_R1.8831.00
262_S273_M1.8591.00
29_E267_K1.8521.00
33_A264_L1.8401.00
84_I124_T1.8371.00
235_V240_I1.8321.00
406_L409_I1.8241.00
340_S343_E1.8201.00
118_L153_V1.8141.00
106_L117_A1.8141.00
332_Y369_A1.7751.00
180_K215_E1.7751.00
383_E411_G1.7661.00
112_A116_E1.7501.00
167_I182_L1.7381.00
404_R411_G1.7201.00
118_L152_T1.7101.00
184_S216_G1.6981.00
125_I135_V1.6951.00
32_K63_L1.6951.00
75_G87_A1.6761.00
254_K257_K1.6731.00
353_S357_I1.6711.00
156_T159_D1.6451.00
85_E131_H1.6431.00
151_V185_A1.6411.00
194_E219_T1.6371.00
239_Q277_Y1.6341.00
30_I265_I1.6261.00
195_Y218_A1.6251.00
24_V59_R1.6141.00
404_R413_K1.6111.00
114_R146_D1.6081.00
328_L347_I1.5971.00
6_I39_V1.5931.00
406_L411_G1.5851.00
55_E59_R1.5781.00
85_E89_E1.5611.00
180_K184_S1.5611.00
296_V316_D1.5231.00
155_R189_E1.5141.00
22_F269_S1.5111.00
241_V255_L1.4921.00
419_S423_D1.4891.00
330_D333_E1.4891.00
350_K353_S1.4881.00
259_Q313_R1.4851.00
101_V153_V1.4831.00
69_I91_E1.4831.00
288_K320_D1.4821.00
169_D209_N1.4731.00
179_T197_I1.4681.00
106_L146_D1.4681.00
137_F153_V1.4571.00
127_Y131_H1.4481.00
122_A159_D1.4481.00
116_E119_R1.4441.00
59_R62_K1.4431.00
331_K362_D1.4281.00
106_L145_T1.4261.00
349_A353_S1.4071.00
103_D107_K1.4041.00
174_L179_T1.3971.00
125_I160_A1.3911.00
139_A154_S1.3791.00
151_V155_R1.3721.00
329_R333_E1.3651.00
402_V415_V1.3641.00
288_K322_Y1.3641.00
33_A261_V1.3631.00
242_A255_L1.3581.00
304_E315_R1.3561.00
350_K371_E1.3541.00
47_P57_I1.3521.00
378_K381_P1.3491.00
329_R341_E1.3431.00
183_F195_Y1.3431.00
210_A240_I1.3351.00
379_P408_V1.3331.00
39_V253_V1.3301.00
383_E404_R1.3161.00
183_F216_G1.3161.00
52_D356_T1.3151.00
122_A157_A1.3091.00
144_R173_I1.3001.00
348_L352_K1.2981.00
115_E118_L1.2931.00
154_S167_I1.2921.00
144_R178_K1.2921.00
407_S410_N1.2911.00
148_D151_V1.2871.00
86_I89_E1.2861.00
183_F197_I1.2831.00
6_I241_V1.2821.00
350_K372_V1.2821.00
112_A117_A1.2811.00
55_E58_K1.2801.00
181_E185_A1.2711.00
158_R193_L1.2691.00
158_R165_V1.2671.00
437_N441_E1.2651.00
151_V186_L1.2611.00
54_Y86_I1.2581.00
98_F291_V1.2551.00
187_I219_T1.2521.00
103_D106_L1.2491.00
400_T415_V1.2481.00
106_L149_F1.2471.00
285_F311_F1.2431.00
143_S174_L1.2280.99
31_A56_G1.2270.99
358_R364_D1.2240.99
211_L243_A1.2150.99
207_V240_I1.2090.99
88_A132_G1.1930.99
264_L268_Y1.1710.99
331_K334_K1.1700.99
118_L156_T1.1680.99
88_A131_H1.1600.99
99_Y137_F1.1580.99
223_A241_V1.1530.99
325_K345_D1.1520.99
25_D59_R1.1510.99
225_V265_I1.1500.99
212_A216_G1.1470.99
201_N204_G1.1470.99
140_E303_Y1.1430.99
201_N278_P1.1400.99
416_M427_K1.1350.99
155_R159_D1.1330.99
134_K163_D1.1290.99
366_L370_E1.1280.99
210_A235_V1.1200.99
105_H141_D1.1200.99
148_D152_T1.1180.99
100_G141_D1.1180.99
380_R407_S1.1130.99
245_K251_E1.1100.99
121_I156_T1.1090.99
36_D260_Y1.1080.99
403_T414_E1.1060.99
100_G105_H1.1050.99
41_M134_K1.1010.99
22_F268_Y1.1000.99
72_E134_K1.0900.99
347_I368_L1.0860.99
13_E234_I1.0860.99
60_I73_I1.0810.99
332_Y339_I1.0700.99
183_F186_L1.0680.99
44_A57_I1.0680.99
223_A237_L1.0670.98
155_R158_R1.0670.98
156_T160_A1.0670.98
110_H140_E1.0640.98
201_N206_A1.0590.98
414_E432_D1.0500.98
104_I108_A1.0470.98
40_S70_T1.0420.98
126_S160_A1.0350.98
155_R190_V1.0320.98
33_A260_Y1.0240.98
151_V189_E1.0170.98
147_F182_L1.0160.98
239_Q278_P1.0140.98
259_Q263_S1.0110.98
118_L149_F1.0110.98
386_E400_T1.0100.98
175_Y248_F1.0080.98
22_F30_I1.0060.98
138_T168_A1.0040.98
152_T156_T1.0040.98
141_D144_R1.0010.98
245_K310_T1.0000.98
434_N441_E1.0000.98
51_P86_I0.9980.98
17_T20_V0.9950.98
415_V431_K0.9910.98
110_H303_Y0.9890.98
330_D334_K0.9870.97
48_A82_R0.9860.97
72_E92_V0.9860.97
79_A124_T0.9850.97
64_K69_I0.9840.97
131_H134_K0.9800.97
109_K303_Y0.9790.97
346_Q372_V0.9710.97
28_V59_R0.9570.97
438_Q441_E0.9560.97
210_A223_A0.9530.97
33_A257_K0.9510.97
433_S436_L0.9510.97
149_F153_V0.9500.97
109_K294_A0.9470.97
423_D427_K0.9470.97
57_I75_G0.9450.97
185_A188_R0.9410.97
123_E127_Y0.9410.97
379_P407_S0.9400.97
329_R344_M0.9400.97
136_R196_D0.9400.97
111_K298_S0.9380.97
96_A138_T0.9300.96
77_S87_A0.9270.96
445_A449_V0.9270.96
447_K452_T0.9250.96
148_D185_A0.9240.96
100_G140_E0.9180.96
78_R83_D0.9130.96
177_S181_E0.9080.96
7_L96_A0.9070.96
394_D400_T0.9070.96
52_D321_K0.9050.96
72_E93_D0.9040.96
211_L248_F0.8990.96
207_V210_A0.8980.96
386_E402_V0.8980.96
339_I347_I0.8950.96
210_A214_V0.8910.95
384_Q404_R0.8890.95
79_A97_I0.8870.95
181_E184_S0.8870.95
127_Y130_S0.8840.95
204_G278_P0.8820.95
175_Y215_E0.8820.95
204_G236_P0.8800.95
413_K417_E0.8790.95
212_A215_E0.8770.95
412_V432_D0.8740.95
23_T26_Q0.8720.95
92_V133_V0.8710.95
74_V94_R0.8700.95
354_N368_L0.8690.95
437_N440_I0.8690.95
143_S182_L0.8670.95
20_V228_L0.8610.95
398_Y402_V0.8570.94
207_V235_V0.8470.94
153_V157_A0.8460.94
88_A93_D0.8460.94
228_L271_I0.8430.94
426_V430_A0.8430.94
20_V30_I0.8400.94
341_E344_M0.8330.93
293_V327_A0.8330.93
35_S69_I0.8300.93
341_E345_D0.8300.93
177_S180_K0.8240.93
103_D145_T0.8240.93
207_V239_Q0.8230.93
180_K212_A0.8220.93
76_H138_T0.8220.93
363_V367_E0.8200.93
128_A135_V0.8170.93
28_V32_K0.8140.93
345_D349_A0.8130.93
28_V63_L0.8090.92
96_A166_S0.8090.92
139_A150_L0.8070.92
335_L362_D0.8070.92
30_I34_L0.8030.92
109_K302_T0.8030.92
49_V322_Y0.8010.92
205_L211_L0.7980.92
425_L429_Q0.7920.92
157_A162_A0.7910.92
18_P283_Y0.7880.91
328_L365_L0.7880.91
179_T183_F0.7870.91
139_A167_I0.7840.91
263_S267_K0.7830.91
199_A213_A0.7810.91
54_Y90_L0.7780.91
57_I73_I0.7780.91
9_S105_H0.7760.91
318_T322_Y0.7750.91
39_V241_V0.7740.91
126_S130_S0.7740.91
125_I157_A0.7720.91
158_R192_N0.7710.91
179_T199_A0.7690.90
245_K252_V0.7690.90
404_R417_E0.7680.90
400_T417_E0.7670.90
24_V56_G0.7670.90
440_I443_I0.7650.90
346_Q349_A0.7640.90
148_D189_E0.7640.90
380_R405_R0.7620.90
225_V261_V0.7590.90
186_L190_V0.7580.90
136_R222_H0.7580.90
106_L112_A0.7550.90
219_T250_I0.7540.90
262_S280_T0.7500.89
42_I71_S0.7470.89
97_I161_G0.7470.89
242_A279_I0.7470.89
119_R122_A0.7470.89
177_S212_A0.7460.89
20_V271_I0.7460.89
136_R166_S0.7450.89
309_E314_T0.7450.89
15_E22_F0.7440.89
96_A136_R0.7440.89
63_L69_I0.7410.89
205_L243_A0.7400.89
107_K111_K0.7390.89
407_S412_V0.7390.89
328_L348_L0.7380.89
31_A60_I0.7360.88
186_L195_Y0.7340.88
88_A133_V0.7330.88
428_V432_D0.7320.88
236_P239_Q0.7290.88
394_D397_V0.7270.88
118_L122_A0.7260.88
430_A437_N0.7230.88
134_K164_R0.7220.87
343_E346_Q0.7190.87
419_S450_R0.7160.87
46_H291_V0.7160.87
433_S440_I0.7160.87
402_V413_K0.7140.87
214_V250_I0.7130.87
433_S438_Q0.7080.86
370_E375_R0.7080.86
425_L428_V0.7080.86
123_E126_S0.7070.86
44_A73_I0.7060.86
354_N357_I0.7060.86
17_T271_I0.7040.86
339_I369_A0.7030.86
236_P277_Y0.7000.86
433_S437_N0.6990.86
449_V454_T0.6980.86
238_Q277_Y0.6960.86
97_I124_T0.6950.85
242_A306_M0.6910.85
46_H76_H0.6900.85
31_A35_S0.6900.85
136_R220_I0.6880.85
347_I369_A0.6880.85
266_E272_P0.6870.85
297_L330_D0.6870.85
394_D415_V0.6850.85
100_G110_H0.6840.85
17_T228_L0.6840.85
408_V412_V0.6830.84
360_Y364_D0.6820.84
113_T119_R0.6820.84
430_A450_R0.6820.84
17_T276_N0.6800.84
164_R194_E0.6790.84
367_E371_E0.6790.84
228_L269_S0.6780.84
412_V431_K0.6740.84
40_S253_V0.6730.84
382_P385_I0.6730.84
28_V60_I0.6710.83
102_S105_H0.6700.83
76_H166_S0.6680.83
332_Y365_L0.6670.83
154_S190_V0.6660.83
160_A163_D0.6650.83
12_R16_Q0.6650.83
271_I274_P0.6620.83
104_I302_T0.6620.83
242_A310_T0.6600.82
143_S167_I0.6600.82
25_D29_E0.6590.82
138_T166_S0.6590.82
116_E120_V0.6580.82
37_L258_L0.6580.82
174_L178_K0.6580.82
274_P278_P0.6560.82
154_S186_L0.6560.82
41_M74_V0.6560.82
288_K321_K0.6530.82
98_F138_T0.6520.82
120_V124_T0.6510.82
436_L441_E0.6510.82
169_D179_T0.6500.81
361_R364_D0.6490.81
26_Q270_G0.6480.81
167_I183_F0.6460.81
215_E248_F0.6460.81
309_E315_R0.6450.81
48_A86_I0.6440.81
346_Q350_K0.6420.81
261_V265_I0.6420.81
100_G109_K0.6420.81
35_S73_I0.6400.80
51_P353_S0.6370.80
243_A279_I0.6360.80
398_Y417_E0.6350.80
328_L344_M0.6350.80
196_D222_H0.6340.80
164_R220_I0.6330.80
225_V238_Q0.6310.79
197_I214_V0.6310.79
143_S179_T0.6310.79
434_N438_Q0.6310.79
9_S13_E0.6300.79
214_V244_I0.6300.79
386_E415_V0.6300.79
100_G138_T0.6300.79
80_V120_V0.6290.79
45_G57_I0.6280.79
107_K113_T0.6280.79
436_L440_I0.6260.79
20_V270_G0.6260.79
49_V321_K0.6250.79
421_D425_L0.6240.79
140_E292_H0.6240.79
28_V56_G0.6220.79
347_I373_T0.6200.78
326_H330_D0.6190.78
431_K434_N0.6180.78
384_Q398_Y0.6170.78
6_I210_A0.6170.78
275_P282_D0.6150.78
274_P277_Y0.6150.78
97_I125_I0.6140.78
265_I269_S0.6140.78
182_L186_L0.6140.78
76_H81_K0.6130.78
114_R145_T0.6120.77
102_S141_D0.6120.77
173_I305_F0.6120.77
155_R193_L0.6110.77
151_V190_V0.6110.77
364_D367_E0.6090.77
407_S432_D0.6080.77
293_V323_T0.6060.77
7_L222_H0.6060.77
354_N360_Y0.6050.77
419_S444_R0.6040.76
178_K247_H0.6040.76
416_M431_K0.6040.76
94_R134_K0.6030.76
29_E268_Y0.6020.76
446_T453_L0.6010.76
7_L74_V0.6010.76
394_D398_Y0.6010.76
26_Q358_R0.6010.76
38_G70_T0.6010.76
13_E16_Q0.6010.76
101_V139_A0.6000.76
165_V195_Y0.5990.76
120_V123_E0.5980.76
54_Y89_E0.5970.76
350_K354_N0.5970.76
100_G103_D0.5960.76
60_I63_L0.5960.76
275_P283_Y0.5950.75
439_I442_S0.5940.75
434_N437_N0.5940.75
129_R133_V0.5930.75
37_L241_V0.5930.75
447_K450_R0.5930.75
402_V417_E0.5910.75
29_E264_L0.5910.75
152_T155_R0.5900.75
115_E149_F0.5900.75
73_I76_H0.5880.75
20_V268_Y0.5870.74
87_A95_I0.5860.74
75_G92_V0.5860.74
6_I252_V0.5850.74
95_I132_G0.5850.74
263_S282_D0.5850.74
407_S436_L0.5830.74
199_A235_V0.5830.74
105_H144_R0.5800.74
287_H292_H0.5800.74
414_E417_E0.5790.73
237_L258_L0.5790.73
100_G137_F0.5770.73
9_S125_I0.5770.73
99_Y110_H0.5760.73
98_F137_F0.5750.73
130_S133_V0.5740.73
147_F181_E0.5730.73
398_Y413_K0.5720.73
9_S141_D0.5720.73
422_Y439_I0.5710.72
97_I128_A0.5710.72
332_Y335_L0.5700.72
104_I301_R0.5700.72
15_E322_Y0.5700.72
405_R414_E0.5690.72
98_F352_K0.5690.72
153_V156_T0.5670.72
427_K431_K0.5610.71
34_L42_I0.5610.71
398_Y404_R0.5610.71
412_V434_N0.5600.71
335_L366_L0.5590.71
46_H50_S0.5590.71
201_N274_P0.5590.71
224_T237_L0.5550.70
238_Q242_A0.5550.70
157_A165_V0.5550.70
54_Y57_I0.5550.70
164_R219_T0.5540.70
256_D310_T0.5540.70
385_I399_T0.5530.70
428_V431_K0.5520.70
143_S173_I0.5510.70
169_D172_G0.5510.70
406_L410_N0.5500.70
100_G117_A0.5500.70
261_V264_L0.5500.70
32_K36_D0.5500.70
111_K294_A0.5490.69
122_A153_V0.5480.69
342_A345_D0.5470.69
313_R316_D0.5470.69
99_Y117_A0.5460.69
287_H304_E0.5450.69
403_T425_L0.5450.69
76_H98_F0.5430.69
54_Y58_K0.5420.68
166_S222_H0.5420.68
109_K295_G0.5420.68
447_K453_L0.5420.68
426_V437_N0.5390.68
292_H303_Y0.5380.68
190_V195_Y0.5380.68
203_L305_F0.5360.68
105_H302_T0.5360.68
77_S98_F0.5350.68
15_E321_K0.5350.68
245_K253_V0.5350.68
339_I344_M0.5340.67
399_T403_T0.5340.67
29_E260_Y0.5340.67
402_V414_E0.5330.67
8_D11_L0.5330.67
294_A327_A0.5320.67
57_I61_V0.5320.67
69_I92_V0.5310.67
17_T22_F0.5310.67
124_T157_A0.5300.67
20_V265_I0.5300.67
387_A421_D0.5290.67
411_G415_V0.5290.67
6_I223_A0.5280.66
226_N273_M0.5280.66
395_S398_Y0.5280.66
384_Q394_D0.5280.66
183_F218_A0.5280.66
106_L113_T0.5270.66
291_V302_T0.5270.66
331_K365_L0.5270.66
167_I179_T0.5260.66
24_V28_V0.5250.66
226_N265_I0.5250.66
100_G145_T0.5240.66
154_S182_L0.5230.66
79_A83_D0.5230.66
273_M280_T0.5230.66
386_E413_K0.5230.66
351_I365_L0.5210.65
354_N364_D0.5200.65
179_T213_A0.5190.65
298_S329_R0.5170.65
101_V138_T0.5160.65
84_I127_Y0.5160.65
7_L220_I0.5160.65
103_D149_F0.5160.65
30_I334_K0.5160.65
22_F265_I0.5160.65
405_R412_V0.5140.64
129_R162_A0.5140.64
400_T413_K0.5130.64
295_G303_Y0.5130.64
321_K352_K0.5120.64
332_Y337_V0.5120.64
399_T432_D0.5120.64
449_V452_T0.5100.64
207_V223_A0.5100.64
258_L316_D0.5100.64
95_I133_V0.5100.64
380_R433_S0.5100.64
412_V436_L0.5090.64
300_P315_R0.5090.64
308_P316_D0.5090.64
411_G417_E0.5070.63
172_G209_N0.5070.63
393_C396_N0.5060.63
380_R432_D0.5060.63
110_H137_F0.5060.63
13_E27_R0.5040.63
121_I126_S0.5040.63
386_E394_D0.5030.63
114_R148_D0.5020.63
166_S196_D0.5020.63
433_S441_E0.5010.62
408_V411_G0.5010.62
61_V91_E0.5010.62
125_I162_A0.5010.62
242_A258_L0.5000.62
365_L369_A0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hq1A 2 0.9653 100 0.209 Contact Map
4ov4A 2 0.7787 100 0.286 Contact Map
2ztjA 2 0.6616 100 0.292 Contact Map
3ivsA 2 0.7636 100 0.312 Contact Map
3rmjA 2 0.6443 100 0.319 Contact Map
3bleA 2 0.6508 100 0.404 Contact Map
3eegA 2 0.5683 100 0.447 Contact Map
2qf7A 4 0.9414 100 0.509 Contact Map
4qshA 4 0.885 100 0.521 Contact Map
2cw6A 5 0.5965 100 0.526 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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