GREMLIN Database
Q97ZD9 - Ribose 5-phosphate isomerase (RpiA)
UniProt: Q97ZD9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 227 (214)
Sequences: 2458 (1467)
Seq/√Len: 100.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
97_G164_I4.7911.00
10_Y13_N3.8091.00
86_T90_I3.8011.00
74_Q110_K3.2841.00
78_Y109_S3.2731.00
35_V38_S2.9721.00
186_D198_T2.9711.00
142_K173_L2.8161.00
116_G211_L2.7581.00
181_N184_E2.7201.00
20_I75_P2.5791.00
9_T35_V2.5101.00
32_L79_V2.3611.00
89_G209_I2.2841.00
34_E58_E2.2801.00
50_A56_E2.2511.00
190_K198_T2.2261.00
33_I55_T2.2041.00
40_E43_K2.1841.00
85_V91_M2.1841.00
145_L189_I2.1441.00
85_V209_I2.1411.00
85_V116_G2.1361.00
48_F64_F2.0301.00
21_I77_I2.0301.00
56_E60_S1.9511.00
25_T98_A1.9291.00
7_L210_I1.8811.00
53_I56_E1.8101.00
3_P118_S1.7971.00
51_S105_L1.7891.00
5_E9_T1.7891.00
111_Y208_K1.7871.00
23_V59_L1.7671.00
150_F175_V1.7071.00
187_R191_N1.6601.00
95_G127_I1.6481.00
91_M114_F1.6471.00
134_I196_V1.6281.00
87_K123_D1.6191.00
213_N218_I1.6171.00
144_K147_K1.6121.00
184_E188_M1.6091.00
154_I163_P1.5141.00
32_L115_I1.4561.00
100_L134_I1.4231.00
121_L211_L1.4121.00
67_L72_A1.4101.00
101_R168_N1.3901.00
84_I125_K1.3740.99
9_T38_S1.3680.99
78_Y112_R1.3670.99
79_V115_I1.3670.99
76_E110_K1.3650.99
133_V173_L1.3580.99
90_I183_C1.3460.99
157_G160_K1.3260.99
14_Y113_I1.2940.99
131_I175_V1.2900.99
5_E31_K1.2770.99
140_Y193_P1.2700.99
41_N44_E1.2540.99
16_R19_K1.2510.99
148_M188_M1.2490.99
3_P214_E1.2320.99
179_T182_L1.2300.99
186_D190_K1.2070.99
29_V32_L1.2000.99
150_F177_V1.1970.99
84_I126_V1.1820.98
69_L108_F1.1760.98
57_I61_K1.1750.98
12_L32_L1.1750.98
47_L67_L1.1640.98
30_K54_D1.1600.98
118_S213_N1.1540.98
118_S214_E1.1470.98
97_G172_I1.1450.98
190_K193_P1.1380.98
107_Y193_P1.1370.98
213_N217_R1.1350.98
142_K146_E1.1330.98
85_V121_L1.1310.98
85_V211_L1.1270.98
37_S62_R1.1270.98
40_E44_E1.1180.98
12_L35_V1.1170.98
183_C203_K1.1120.98
29_V50_A1.1120.98
140_Y144_K1.1090.98
12_L39_E1.1050.97
118_S121_L1.1010.97
25_T51_S1.0960.97
116_G209_I1.0890.97
32_L36_L1.0850.97
82_F116_G1.0820.97
8_A12_L1.0820.97
39_E42_L1.0810.97
146_E151_T1.0760.97
189_I195_I1.0530.97
19_K77_I1.0430.96
84_I122_K1.0420.96
210_I217_R1.0380.96
31_K34_E1.0360.96
99_L172_I1.0340.96
14_Y208_K1.0330.96
138_V142_K1.0320.96
78_Y106_A1.0270.96
152_V173_L1.0260.96
53_I57_I1.0080.96
30_K34_E0.9910.95
17_G45_S0.9900.95
112_R205_L0.9830.95
49_V75_P0.9790.95
179_T185_F0.9780.95
99_L131_I0.9750.95
14_Y77_I0.9670.95
212_A217_R0.9660.95
165_I169_G0.9600.94
157_G162_G0.9580.94
30_K58_E0.9530.94
124_T180_E0.9530.94
141_V192_I0.9530.94
109_S112_R0.9490.94
111_Y207_N0.9460.94
49_V72_A0.9440.94
51_S78_Y0.9240.93
3_P212_A0.9230.93
73_I143_Y0.9170.93
38_S42_L0.9100.93
142_K152_V0.8900.92
154_I171_V0.8900.92
59_L66_V0.8870.92
21_I46_S0.8800.91
68_S71_S0.8680.91
14_Y111_Y0.8670.91
5_E34_E0.8620.90
8_A31_K0.8600.90
107_Y144_K0.8550.90
39_E43_K0.8500.90
157_G161_M0.8330.89
138_V154_I0.8330.89
165_I171_V0.8310.89
39_E44_E0.8310.89
164_I172_I0.8290.89
156_E163_P0.8260.88
143_Y146_E0.8240.88
84_I127_I0.8230.88
138_V173_L0.8180.88
91_M206_Y0.8150.88
10_Y219_E0.8080.87
31_K35_V0.8080.87
49_V69_L0.8060.87
131_I195_I0.8030.87
124_T178_K0.7960.87
57_I60_S0.7930.86
33_I58_E0.7910.86
34_E62_R0.7910.86
128_D176_S0.7890.86
3_P213_N0.7890.86
78_Y105_L0.7850.86
100_L166_S0.7800.85
3_P217_R0.7770.85
189_I198_T0.7770.85
101_R136_V0.7730.85
10_Y210_I0.7720.85
58_E62_R0.7710.85
19_K76_E0.7700.85
94_G199_G0.7670.85
29_V33_I0.7660.84
129_I200_I0.7640.84
6_L212_A0.7600.84
17_G44_E0.7580.84
131_I189_I0.7530.83
125_K128_D0.7490.83
14_Y210_I0.7460.83
133_V141_V0.7460.83
184_E187_R0.7450.83
152_V175_V0.7420.83
23_V55_T0.7360.82
41_N62_R0.7330.82
7_L115_I0.7330.82
90_I182_L0.7290.81
95_G125_K0.7260.81
145_L150_F0.7260.81
67_L71_S0.7240.81
138_V171_V0.7240.81
16_R111_Y0.7230.81
108_F140_Y0.7140.80
151_T176_S0.7130.80
34_E61_K0.7130.80
3_P216_G0.7110.80
58_E61_K0.7090.80
15_L39_E0.7060.79
134_I168_N0.7030.79
215_Q218_I0.7000.79
130_P199_G0.6940.78
25_T29_V0.6940.78
94_G130_P0.6940.78
25_T31_K0.6930.78
8_A35_V0.6900.78
54_D57_I0.6830.77
116_G121_L0.6810.77
185_F200_I0.6800.77
70_F138_V0.6800.77
179_T200_I0.6790.77
7_L212_A0.6780.76
15_L77_I0.6720.76
18_K45_S0.6640.75
143_Y147_K0.6630.75
166_S172_I0.6630.75
37_S64_F0.6620.75
41_N45_S0.6620.75
131_I145_L0.6570.74
100_L196_V0.6540.74
145_L195_I0.6510.74
183_C187_R0.6490.73
50_A68_S0.6460.73
73_I108_F0.6460.73
89_G211_L0.6410.72
153_K176_S0.6380.72
16_R187_R0.6380.72
142_K154_I0.6380.72
149_G152_V0.6370.72
160_K164_I0.6310.71
182_L185_F0.6290.71
3_P6_L0.6260.71
4_K28_T0.6260.71
198_T202_C0.6240.70
50_A53_I0.6230.70
15_L18_K0.6220.70
23_V30_K0.6200.70
69_L140_Y0.6170.70
4_K27_K0.6170.70
3_P7_L0.6170.70
136_V141_V0.6170.70
93_K96_G0.6130.69
17_G43_K0.6130.69
139_S142_K0.6120.69
42_L76_E0.6070.68
121_L218_I0.6070.68
213_N216_G0.6050.68
190_K197_E0.6040.68
137_G140_Y0.6030.68
6_L9_T0.6000.67
90_I203_K0.6000.67
20_I72_A0.5980.67
56_E66_V0.5940.67
86_T205_L0.5910.66
46_S65_K0.5910.66
14_Y219_E0.5860.66
125_K129_I0.5850.65
122_K125_K0.5850.65
69_L105_L0.5850.65
135_S171_V0.5830.65
122_K126_V0.5820.65
53_I101_R0.5790.65
92_I98_A0.5790.65
137_G141_V0.5760.64
16_R76_E0.5730.64
12_L38_S0.5730.64
92_I129_I0.5710.64
17_G40_E0.5680.63
29_V54_D0.5670.63
25_T199_G0.5670.63
98_A199_G0.5600.62
25_T172_I0.5600.62
87_K121_L0.5590.62
50_A66_V0.5570.62
48_F59_L0.5560.62
18_K21_I0.5560.62
148_M189_I0.5520.61
35_V39_E0.5520.61
17_G41_N0.5490.61
101_R167_D0.5490.61
48_F51_S0.5480.60
91_M116_G0.5480.60
100_L197_E0.5440.60
133_V142_K0.5430.60
34_E38_S0.5410.59
45_S65_K0.5400.59
129_I177_V0.5390.59
131_I173_L0.5380.59
82_F94_G0.5360.59
46_S59_L0.5330.58
82_F114_F0.5330.58
141_V173_L0.5310.58
124_T179_T0.5310.58
94_G98_A0.5310.58
23_V29_V0.5290.58
145_L173_L0.5270.58
33_I62_R0.5260.57
87_K181_N0.5260.57
47_L65_K0.5230.57
67_L73_I0.5200.57
27_K161_M0.5200.57
129_I182_L0.5180.56
82_F199_G0.5180.56
5_E35_V0.5180.56
7_L31_K0.5170.56
153_K156_E0.5160.56
88_D183_C0.5160.56
170_N196_V0.5150.56
144_K192_I0.5130.56
29_V37_S0.5110.55
81_S93_K0.5100.55
48_F67_L0.5080.55
213_N219_E0.5070.55
139_S146_E0.5070.55
89_G217_R0.5060.55
135_S165_I0.5060.55
80_D102_E0.5050.54
90_I205_L0.5040.54
21_I35_V0.5040.54
104_L193_P0.5020.54
60_S65_K0.5010.54
9_T31_K0.5010.54
132_E168_N0.5010.54
138_V152_V0.5000.54
156_E160_K0.5000.54
138_V141_V0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2f8mA 2 0.978 100 0.226 Contact Map
1xtzA 3 0.9956 100 0.231 Contact Map
3hheA 2 0.978 100 0.244 Contact Map
1lk5A 4 0.9736 100 0.245 Contact Map
4nmlA 2 0.9736 100 0.252 Contact Map
4x84A 2 0.9383 100 0.252 Contact Map
1uj6A 2 0.9604 100 0.255 Contact Map
3l7oA 2 0.9736 100 0.258 Contact Map
4gmkA 2 0.9736 100 0.265 Contact Map
3uw1A 2 0.9692 100 0.266 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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