Q97ZD9 - SULSO - GREMLIN Contacts

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Q97ZD9 - Ribose 5-phosphate isomerase (RpiA)

UniProt:	Q97ZD9	Sequences: MDPKELLATYTLNYLRGKKIIGVGTGKTVKKLIEVLSSEENLKESSLFVASSIDTEIELSKRGFKVLSLFSAIQPEIYVDSFDIVTKDGIMIKGGGGALLREKLLAYFSKYRIFIGESTKLKDTKVIDIPIEVISVGVSYVKYKLEKMGFTVKIREGSGKMGPIISDNGNVILDVSVKTENLCEFDRMIKNIPSIVETGIFCKELYNKIILANEQGRIEEMDAGDGI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	227 (214)
Sequences:	2458 (1467)
Seq/√Len:	100.3

ECOLI - RPIA
HALSA - RPIA
SULSO - Q97ZD9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
97_G	164_I	4.791	1.00
10_Y	13_N	3.809	1.00
86_T	90_I	3.801	1.00
74_Q	110_K	3.284	1.00
78_Y	109_S	3.273	1.00
35_V	38_S	2.972	1.00
186_D	198_T	2.971	1.00
142_K	173_L	2.816	1.00
116_G	211_L	2.758	1.00
181_N	184_E	2.720	1.00
20_I	75_P	2.579	1.00
9_T	35_V	2.510	1.00
32_L	79_V	2.361	1.00
89_G	209_I	2.284	1.00
34_E	58_E	2.280	1.00
50_A	56_E	2.251	1.00
190_K	198_T	2.226	1.00
33_I	55_T	2.204	1.00
40_E	43_K	2.184	1.00
85_V	91_M	2.184	1.00
145_L	189_I	2.144	1.00
85_V	209_I	2.141	1.00
85_V	116_G	2.136	1.00
48_F	64_F	2.030	1.00
21_I	77_I	2.030	1.00
56_E	60_S	1.951	1.00
25_T	98_A	1.929	1.00
7_L	210_I	1.881	1.00
53_I	56_E	1.810	1.00
3_P	118_S	1.797	1.00
51_S	105_L	1.789	1.00
5_E	9_T	1.789	1.00
111_Y	208_K	1.787	1.00
23_V	59_L	1.767	1.00
150_F	175_V	1.707	1.00
187_R	191_N	1.660	1.00
95_G	127_I	1.648	1.00
91_M	114_F	1.647	1.00
134_I	196_V	1.628	1.00
87_K	123_D	1.619	1.00
213_N	218_I	1.617	1.00
144_K	147_K	1.612	1.00
184_E	188_M	1.609	1.00
154_I	163_P	1.514	1.00
32_L	115_I	1.456	1.00
100_L	134_I	1.423	1.00
121_L	211_L	1.412	1.00
67_L	72_A	1.410	1.00
101_R	168_N	1.390	1.00
84_I	125_K	1.374	0.99
9_T	38_S	1.368	0.99
78_Y	112_R	1.367	0.99
79_V	115_I	1.367	0.99
76_E	110_K	1.365	0.99
133_V	173_L	1.358	0.99
90_I	183_C	1.346	0.99
157_G	160_K	1.326	0.99
14_Y	113_I	1.294	0.99
131_I	175_V	1.290	0.99
5_E	31_K	1.277	0.99
140_Y	193_P	1.270	0.99
41_N	44_E	1.254	0.99
16_R	19_K	1.251	0.99
148_M	188_M	1.249	0.99
3_P	214_E	1.232	0.99
179_T	182_L	1.230	0.99
186_D	190_K	1.207	0.99
29_V	32_L	1.200	0.99
150_F	177_V	1.197	0.99
84_I	126_V	1.182	0.98
69_L	108_F	1.176	0.98
57_I	61_K	1.175	0.98
12_L	32_L	1.175	0.98
47_L	67_L	1.164	0.98
30_K	54_D	1.160	0.98
118_S	213_N	1.154	0.98
118_S	214_E	1.147	0.98
97_G	172_I	1.145	0.98
190_K	193_P	1.138	0.98
107_Y	193_P	1.137	0.98
213_N	217_R	1.135	0.98
142_K	146_E	1.133	0.98
85_V	121_L	1.131	0.98
85_V	211_L	1.127	0.98
37_S	62_R	1.127	0.98
40_E	44_E	1.118	0.98
12_L	35_V	1.117	0.98
183_C	203_K	1.112	0.98
29_V	50_A	1.112	0.98
140_Y	144_K	1.109	0.98
12_L	39_E	1.105	0.97
118_S	121_L	1.101	0.97
25_T	51_S	1.096	0.97
116_G	209_I	1.089	0.97
32_L	36_L	1.085	0.97
82_F	116_G	1.082	0.97
8_A	12_L	1.082	0.97
39_E	42_L	1.081	0.97
146_E	151_T	1.076	0.97
189_I	195_I	1.053	0.97
19_K	77_I	1.043	0.96
84_I	122_K	1.042	0.96
210_I	217_R	1.038	0.96
31_K	34_E	1.036	0.96
99_L	172_I	1.034	0.96
14_Y	208_K	1.033	0.96
138_V	142_K	1.032	0.96
78_Y	106_A	1.027	0.96
152_V	173_L	1.026	0.96
53_I	57_I	1.008	0.96
30_K	34_E	0.991	0.95
17_G	45_S	0.990	0.95
112_R	205_L	0.983	0.95
49_V	75_P	0.979	0.95
179_T	185_F	0.978	0.95
99_L	131_I	0.975	0.95
14_Y	77_I	0.967	0.95
212_A	217_R	0.966	0.95
165_I	169_G	0.960	0.94
157_G	162_G	0.958	0.94
30_K	58_E	0.953	0.94
124_T	180_E	0.953	0.94
141_V	192_I	0.953	0.94
109_S	112_R	0.949	0.94
111_Y	207_N	0.946	0.94
49_V	72_A	0.944	0.94
51_S	78_Y	0.924	0.93
3_P	212_A	0.923	0.93
73_I	143_Y	0.917	0.93
38_S	42_L	0.910	0.93
142_K	152_V	0.890	0.92
154_I	171_V	0.890	0.92
59_L	66_V	0.887	0.92
21_I	46_S	0.880	0.91
68_S	71_S	0.868	0.91
14_Y	111_Y	0.867	0.91
5_E	34_E	0.862	0.90
8_A	31_K	0.860	0.90
107_Y	144_K	0.855	0.90
39_E	43_K	0.850	0.90
157_G	161_M	0.833	0.89
138_V	154_I	0.833	0.89
165_I	171_V	0.831	0.89
39_E	44_E	0.831	0.89
164_I	172_I	0.829	0.89
156_E	163_P	0.826	0.88
143_Y	146_E	0.824	0.88
84_I	127_I	0.823	0.88
138_V	173_L	0.818	0.88
91_M	206_Y	0.815	0.88
10_Y	219_E	0.808	0.87
31_K	35_V	0.808	0.87
49_V	69_L	0.806	0.87
131_I	195_I	0.803	0.87
124_T	178_K	0.796	0.87
57_I	60_S	0.793	0.86
33_I	58_E	0.791	0.86
34_E	62_R	0.791	0.86
128_D	176_S	0.789	0.86
3_P	213_N	0.789	0.86
78_Y	105_L	0.785	0.86
100_L	166_S	0.780	0.85
3_P	217_R	0.777	0.85
189_I	198_T	0.777	0.85
101_R	136_V	0.773	0.85
10_Y	210_I	0.772	0.85
58_E	62_R	0.771	0.85
19_K	76_E	0.770	0.85
94_G	199_G	0.767	0.85
29_V	33_I	0.766	0.84
129_I	200_I	0.764	0.84
6_L	212_A	0.760	0.84
17_G	44_E	0.758	0.84
131_I	189_I	0.753	0.83
125_K	128_D	0.749	0.83
14_Y	210_I	0.746	0.83
133_V	141_V	0.746	0.83
184_E	187_R	0.745	0.83
152_V	175_V	0.742	0.83
23_V	55_T	0.736	0.82
41_N	62_R	0.733	0.82
7_L	115_I	0.733	0.82
90_I	182_L	0.729	0.81
95_G	125_K	0.726	0.81
145_L	150_F	0.726	0.81
67_L	71_S	0.724	0.81
138_V	171_V	0.724	0.81
16_R	111_Y	0.723	0.81
108_F	140_Y	0.714	0.80
151_T	176_S	0.713	0.80
34_E	61_K	0.713	0.80
3_P	216_G	0.711	0.80
58_E	61_K	0.709	0.80
15_L	39_E	0.706	0.79
134_I	168_N	0.703	0.79
215_Q	218_I	0.700	0.79
130_P	199_G	0.694	0.78
25_T	29_V	0.694	0.78
94_G	130_P	0.694	0.78
25_T	31_K	0.693	0.78
8_A	35_V	0.690	0.78
54_D	57_I	0.683	0.77
116_G	121_L	0.681	0.77
185_F	200_I	0.680	0.77
70_F	138_V	0.680	0.77
179_T	200_I	0.679	0.77
7_L	212_A	0.678	0.76
15_L	77_I	0.672	0.76
18_K	45_S	0.664	0.75
143_Y	147_K	0.663	0.75
166_S	172_I	0.663	0.75
37_S	64_F	0.662	0.75
41_N	45_S	0.662	0.75
131_I	145_L	0.657	0.74
100_L	196_V	0.654	0.74
145_L	195_I	0.651	0.74
183_C	187_R	0.649	0.73
50_A	68_S	0.646	0.73
73_I	108_F	0.646	0.73
89_G	211_L	0.641	0.72
153_K	176_S	0.638	0.72
16_R	187_R	0.638	0.72
142_K	154_I	0.638	0.72
149_G	152_V	0.637	0.72
160_K	164_I	0.631	0.71
182_L	185_F	0.629	0.71
3_P	6_L	0.626	0.71
4_K	28_T	0.626	0.71
198_T	202_C	0.624	0.70
50_A	53_I	0.623	0.70
15_L	18_K	0.622	0.70
23_V	30_K	0.620	0.70
69_L	140_Y	0.617	0.70
4_K	27_K	0.617	0.70
3_P	7_L	0.617	0.70
136_V	141_V	0.617	0.70
93_K	96_G	0.613	0.69
17_G	43_K	0.613	0.69
139_S	142_K	0.612	0.69
42_L	76_E	0.607	0.68
121_L	218_I	0.607	0.68
213_N	216_G	0.605	0.68
190_K	197_E	0.604	0.68
137_G	140_Y	0.603	0.68
6_L	9_T	0.600	0.67
90_I	203_K	0.600	0.67
20_I	72_A	0.598	0.67
56_E	66_V	0.594	0.67
86_T	205_L	0.591	0.66
46_S	65_K	0.591	0.66
14_Y	219_E	0.586	0.66
125_K	129_I	0.585	0.65
122_K	125_K	0.585	0.65
69_L	105_L	0.585	0.65
135_S	171_V	0.583	0.65
122_K	126_V	0.582	0.65
53_I	101_R	0.579	0.65
92_I	98_A	0.579	0.65
137_G	141_V	0.576	0.64
16_R	76_E	0.573	0.64
12_L	38_S	0.573	0.64
92_I	129_I	0.571	0.64
17_G	40_E	0.568	0.63
29_V	54_D	0.567	0.63
25_T	199_G	0.567	0.63
98_A	199_G	0.560	0.62
25_T	172_I	0.560	0.62
87_K	121_L	0.559	0.62
50_A	66_V	0.557	0.62
48_F	59_L	0.556	0.62
18_K	21_I	0.556	0.62
148_M	189_I	0.552	0.61
35_V	39_E	0.552	0.61
17_G	41_N	0.549	0.61
101_R	167_D	0.549	0.61
48_F	51_S	0.548	0.60
91_M	116_G	0.548	0.60
100_L	197_E	0.544	0.60
133_V	142_K	0.543	0.60
34_E	38_S	0.541	0.59
45_S	65_K	0.540	0.59
129_I	177_V	0.539	0.59
131_I	173_L	0.538	0.59
82_F	94_G	0.536	0.59
46_S	59_L	0.533	0.58
82_F	114_F	0.533	0.58
141_V	173_L	0.531	0.58
124_T	179_T	0.531	0.58
94_G	98_A	0.531	0.58
23_V	29_V	0.529	0.58
145_L	173_L	0.527	0.58
33_I	62_R	0.526	0.57
87_K	181_N	0.526	0.57
47_L	65_K	0.523	0.57
67_L	73_I	0.520	0.57
27_K	161_M	0.520	0.57
129_I	182_L	0.518	0.56
82_F	199_G	0.518	0.56
5_E	35_V	0.518	0.56
7_L	31_K	0.517	0.56
153_K	156_E	0.516	0.56
88_D	183_C	0.516	0.56
170_N	196_V	0.515	0.56
144_K	192_I	0.513	0.56
29_V	37_S	0.511	0.55
81_S	93_K	0.510	0.55
48_F	67_L	0.508	0.55
213_N	219_E	0.507	0.55
139_S	146_E	0.507	0.55
89_G	217_R	0.506	0.55
135_S	165_I	0.506	0.55
80_D	102_E	0.505	0.54
90_I	205_L	0.504	0.54
21_I	35_V	0.504	0.54
104_L	193_P	0.502	0.54
60_S	65_K	0.501	0.54
9_T	31_K	0.501	0.54
132_E	168_N	0.501	0.54
138_V	152_V	0.500	0.54
156_E	160_K	0.500	0.54
138_V	141_V	0.500	0.54

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2f8mA	2	0.978	100	0.226	Contact Map
1xtzA	3	0.9956	100	0.231	Contact Map
3hheA	2	0.978	100	0.244	Contact Map
1lk5A	4	0.9736	100	0.245	Contact Map
4nmlA	2	0.9736	100	0.252	Contact Map
4x84A	2	0.9383	100	0.252	Contact Map
1uj6A	2	0.9604	100	0.255	Contact Map
3l7oA	2	0.9736	100	0.258	Contact Map
4gmkA	2	0.9736	100	0.265	Contact Map
3uw1A	2	0.9692	100	0.266	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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