GREMLIN Database
Q97ZD8 - Transposase ISC1217
UniProt: Q97ZD8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 354 (294)
Sequences: 1053 (809)
Seq/√Len: 47.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
189_F205_G3.9901.00
129_I179_L3.4871.00
145_I178_S3.2941.00
89_V172_L3.0541.00
36_L303_F2.9681.00
223_S228_G2.9111.00
287_L307_K2.8881.00
166_K174_E2.8191.00
221_P227_Q2.7521.00
87_L179_L2.7331.00
228_G232_V2.5811.00
89_V187_K2.5501.00
90_D274_R2.5041.00
224_E228_G2.4481.00
91_D192_W2.4361.00
222_V228_G2.4261.00
152_V155_E2.3741.00
204_V271_W2.3071.00
90_D278_E2.2661.00
155_E158_R2.2541.00
128_V281_I2.1751.00
220_V223_S2.1361.00
223_S227_Q2.0891.00
88_I132_K2.0801.00
274_R278_E2.0691.00
143_H175_F2.0501.00
222_V226_P2.0421.00
127_L193_Y2.0170.99
143_H178_S1.9980.99
91_D168_K1.9430.99
220_V229_E1.9080.99
26_T30_K1.8850.99
278_E285_K1.8810.99
145_I174_E1.8750.99
293_S299_R1.8720.99
85_V131_V1.8490.99
154_E157_K1.8350.99
150_R154_E1.8350.99
130_G139_I1.7390.98
142_I182_L1.7260.98
222_V229_E1.7220.98
91_D193_Y1.6940.98
90_D285_K1.6840.98
240_K243_V1.6560.98
152_V158_R1.6530.98
294_F299_R1.6510.98
221_P226_P1.6430.98
32_V59_T1.6320.98
145_I301_S1.6270.97
223_S232_V1.6210.97
222_V227_Q1.6150.97
220_V232_V1.6150.97
62_N65_D1.6010.97
22_I25_M1.5980.97
220_V227_Q1.5830.97
221_P228_G1.5760.97
153_E157_K1.5750.97
193_Y274_R1.5720.97
275_W278_E1.5650.97
22_I30_K1.4660.95
167_T170_D1.4560.95
274_R285_K1.4330.95
225_F232_V1.4290.95
93_H121_E1.4240.95
194_V200_Q1.4220.95
170_D173_L1.4180.94
220_V228_G1.4170.94
63_N292_G1.3990.94
227_Q232_V1.3980.94
224_E229_E1.3790.94
93_H114_C1.3750.93
202_N258_T1.3700.93
228_G231_L1.3660.93
224_E227_Q1.3660.93
296_T307_K1.3660.93
95_H117_H1.3610.93
91_D275_W1.3600.93
153_E158_R1.3550.93
64_L306_L1.3500.93
242_L267_I1.3410.93
89_V129_I1.3380.92
194_V205_G1.3310.92
130_G281_I1.3310.92
168_K193_Y1.3300.92
211_A256_F1.3300.92
303_F310_S1.3270.92
115_R192_W1.3000.91
295_L303_F1.2910.91
86_L270_T1.2900.91
279_V283_E1.2890.91
292_G300_N1.2870.91
275_W285_K1.2830.91
193_Y285_K1.2800.91
147_Y165_F1.2620.90
225_F228_G1.2600.90
243_V246_D1.2590.90
103_P300_N1.2580.90
90_D275_W1.2390.89
108_G288_G1.2290.89
36_L40_A1.1990.88
92_T278_E1.1960.87
221_P225_F1.1950.87
114_C121_E1.1820.87
199_L205_G1.1790.87
69_Q302_G1.1720.86
190_D278_E1.1680.86
49_I52_E1.1680.86
223_S226_P1.1610.86
93_H112_F1.1550.86
28_T33_A1.1540.86
145_I171_A1.1470.85
154_E162_E1.1460.85
21_V24_S1.1450.85
206_E253_R1.1440.85
94_D102_M1.1420.85
297_W301_S1.1410.85
240_K244_I1.1400.85
29_R67_A1.1230.84
20_E25_M1.1150.84
26_T29_R1.1140.83
195_N210_S1.1120.83
38_L41_V1.1080.83
223_S231_L1.0940.82
186_A270_T1.0860.82
221_P224_E1.0820.82
275_W314_V1.0810.82
129_I175_F1.0810.82
285_K314_V1.0760.81
141_V312_L1.0740.81
220_V226_P1.0730.81
108_G148_I1.0670.81
86_L188_V1.0620.80
40_A45_N1.0420.79
109_A122_P1.0410.79
19_N23_L1.0400.79
112_F115_R1.0370.79
87_L184_V1.0340.79
166_K177_S1.0300.78
276_D311_L1.0280.78
57_Y61_L1.0270.78
204_V257_S1.0230.78
128_V141_V1.0200.78
102_M124_I1.0120.77
88_I188_V1.0110.77
114_C125_Q1.0100.77
39_G49_I1.0040.76
91_D281_I0.9980.76
203_T258_T0.9930.76
304_V307_K0.9920.76
141_V280_L0.9910.76
63_N67_A0.9810.75
221_P232_V0.9780.75
96_K109_A0.9740.74
103_P297_W0.9730.74
200_Q205_G0.9720.74
90_D277_I0.9720.74
90_D168_K0.9690.74
274_R281_I0.9680.74
48_E51_Q0.9660.74
72_L76_V0.9650.74
129_I176_L0.9630.73
231_L234_Y0.9630.73
24_S71_K0.9600.73
221_P229_E0.9580.73
158_R163_V0.9570.73
171_A175_F0.9570.73
77_K182_L0.9560.73
306_L310_S0.9550.73
127_L145_I0.9510.72
28_T31_D0.9460.72
139_I280_L0.9450.72
33_A37_V0.9450.72
92_T275_W0.9430.72
211_A254_Y0.9420.72
22_I29_R0.9350.71
249_G257_S0.9330.71
170_D234_Y0.9290.71
205_G256_F0.9270.71
124_I300_N0.9240.70
92_T274_R0.9230.70
260_L263_T0.9220.70
127_L172_L0.9200.70
277_I285_K0.9190.70
103_P124_I0.9160.70
58_E62_N0.9140.69
130_G280_L0.9120.69
126_L300_N0.9100.69
33_A36_L0.9090.69
21_V25_M0.9060.69
227_Q231_L0.9020.68
126_L304_V0.9000.68
281_I285_K0.8940.68
125_Q149_P0.8940.68
153_E156_L0.8930.68
94_D126_L0.8920.68
222_V232_V0.8910.67
129_I187_K0.8910.67
148_I152_V0.8860.67
124_I148_I0.8850.67
45_N50_A0.8850.67
98_Y109_A0.8810.67
31_D236_G0.8800.66
25_M29_R0.8780.66
139_I276_D0.8750.66
112_F124_I0.8730.66
159_R163_V0.8710.66
70_A178_S0.8700.66
299_R303_F0.8690.66
90_D193_Y0.8590.65
117_H121_E0.8590.65
188_V270_T0.8570.64
114_C117_H0.8560.64
32_V35_R0.8560.64
141_V311_L0.8550.64
94_D304_V0.8550.64
48_E293_S0.8540.64
127_L171_A0.8540.64
37_V309_L0.8520.64
230_Y233_E0.8490.64
92_T285_K0.8450.63
45_N118_K0.8450.63
240_K245_D0.8400.63
279_V282_R0.8360.62
227_Q233_E0.8330.62
70_A74_E0.8320.62
101_A129_I0.8260.62
18_V34_K0.8240.61
72_L80_V0.8220.61
125_Q168_K0.8200.61
154_E158_R0.8190.61
111_I122_P0.8180.61
239_I242_L0.8150.61
112_F121_E0.8150.61
207_L211_A0.8090.60
214_V219_S0.8030.59
18_V33_A0.8000.59
17_A21_V0.7990.59
77_K80_V0.7970.59
26_T32_V0.7950.59
189_F192_W0.7920.58
161_E164_K0.7920.58
176_L233_E0.7900.58
29_R296_T0.7850.58
98_Y295_L0.7840.58
36_L293_S0.7820.57
122_P149_P0.7800.57
115_R121_E0.7790.57
63_N69_Q0.7770.57
207_L256_F0.7710.56
28_T36_L0.7700.56
255_F271_W0.7670.56
48_E52_E0.7670.56
93_H120_F0.7670.56
189_F194_V0.7670.56
94_D128_V0.7660.56
127_L147_Y0.7600.55
147_Y168_K0.7600.55
150_R187_K0.7590.55
207_L278_E0.7540.55
241_L254_Y0.7490.54
91_D277_I0.7470.54
281_I284_L0.7430.53
220_V225_F0.7420.53
21_V27_G0.7410.53
102_M292_G0.7390.53
181_G185_K0.7360.53
40_A284_L0.7340.53
83_H156_L0.7330.52
220_V224_E0.7310.52
284_L289_L0.7280.52
17_A20_E0.7270.52
27_G31_D0.7230.51
23_L30_K0.7220.51
193_Y275_W0.7220.51
132_K273_N0.7190.51
29_R33_A0.7180.51
18_V21_V0.7160.51
226_P229_E0.7140.51
230_Y235_L0.7100.50
189_F208_K0.7100.50
257_S293_S0.7080.50
191_S207_L0.7060.50
191_S208_K0.7040.50
95_H121_E0.7030.50
225_F233_E0.7010.49
223_S230_Y0.6980.49
224_E230_Y0.6980.49
227_Q265_E0.6960.49
277_I287_L0.6950.49
92_T304_V0.6910.48
21_V213_V0.6900.48
82_D136_N0.6870.48
110_Q151_K0.6850.48
39_G108_G0.6820.47
127_L168_K0.6820.47
114_C120_F0.6820.47
96_K102_M0.6790.47
69_Q98_Y0.6790.47
18_V37_V0.6780.47
193_Y278_E0.6770.47
278_E281_I0.6770.47
142_I237_T0.6740.47
103_P152_V0.6740.47
190_D274_R0.6740.47
102_M146_A0.6710.46
127_L289_L0.6700.46
115_R120_F0.6700.46
112_F149_P0.6690.46
142_I179_L0.6670.46
184_V282_R0.6640.46
93_H125_Q0.6630.46
102_M118_K0.6620.45
103_P301_S0.6620.45
114_C275_W0.6600.45
48_E299_R0.6590.45
40_A303_F0.6580.45
68_A302_G0.6570.45
127_L274_R0.6570.45
271_W274_R0.6550.45
74_E265_E0.6520.44
255_F268_I0.6500.44
102_M126_L0.6450.44
58_E292_G0.6440.44
221_P233_E0.6420.43
208_K212_R0.6420.43
197_R251_G0.6410.43
239_I243_V0.6410.43
113_Y183_N0.6410.43
278_E314_V0.6400.43
71_K74_E0.6400.43
41_V100_R0.6370.43
19_N27_G0.6350.43
74_E210_S0.6320.42
275_W281_I0.6310.42
302_G305_A0.6300.42
67_A148_I0.6270.42
246_D249_G0.6270.42
111_I120_F0.6250.42
296_T308_A0.6210.41
32_V63_N0.6210.41
231_L240_K0.6200.41
94_D303_F0.6190.41
40_A306_L0.6180.41
69_Q305_A0.6170.41
48_E311_L0.6170.41
131_V189_F0.6160.41
20_E24_S0.6140.41
124_I303_F0.6100.40
192_W275_W0.6090.40
45_N291_G0.6070.40
72_L75_V0.6060.40
257_S267_I0.6050.40
225_F230_Y0.6050.40
288_G291_G0.6040.40
75_V80_V0.6020.40
102_M293_S0.6010.40
153_E162_E0.6000.39
76_V308_A0.6000.39
150_R237_T0.6000.39
39_G60_V0.5990.39
282_R285_K0.5960.39
226_P232_V0.5940.39
22_I27_G0.5920.39
174_E261_N0.5910.39
34_K38_L0.5900.38
18_V22_I0.5900.38
221_P231_L0.5890.38
71_K75_V0.5890.38
38_L157_K0.5880.38
111_I121_E0.5860.38
92_T289_L0.5850.38
172_L187_K0.5830.38
111_I253_R0.5830.38
21_V34_K0.5830.38
244_I247_Y0.5830.38
135_V138_Q0.5820.38
179_L182_L0.5810.38
29_R32_V0.5800.38
298_V302_G0.5790.37
300_N304_V0.5760.37
32_V62_N0.5750.37
67_A142_I0.5740.37
292_G299_R0.5740.37
289_L304_V0.5730.37
112_F125_Q0.5710.37
73_I77_K0.5680.36
116_S290_E0.5680.36
17_A31_D0.5660.36
283_E286_A0.5650.36
41_V241_L0.5620.36
37_V142_I0.5620.36
157_K162_E0.5600.36
65_D299_R0.5550.35
98_Y283_E0.5530.35
48_E257_S0.5530.35
295_L310_S0.5510.35
263_T266_D0.5510.35
62_N299_R0.5510.35
111_I118_K0.5510.35
168_K192_W0.5500.35
168_K274_R0.5450.34
103_P126_L0.5430.34
97_L121_E0.5430.34
192_W208_K0.5420.34
263_T269_T0.5410.34
296_T311_L0.5400.34
22_I26_T0.5380.34
266_D270_T0.5380.34
89_V223_S0.5370.34
152_V157_K0.5360.34
154_E164_K0.5360.34
69_Q306_L0.5360.34
142_I231_L0.5340.33
226_P230_Y0.5340.33
114_C141_V0.5330.33
95_H116_S0.5330.33
222_V234_Y0.5330.33
40_A310_S0.5320.33
19_N34_K0.5300.33
167_T285_K0.5280.33
91_D191_S0.5230.32
108_G146_A0.5210.32
147_Y193_Y0.5200.32
60_V63_N0.5190.32
37_V72_L0.5180.32
252_R309_L0.5180.32
80_V140_Y0.5180.32
90_D190_D0.5160.32
123_A245_D0.5160.32
60_V142_I0.5160.32
233_E237_T0.5160.32
85_V185_K0.5150.32
57_Y275_W0.5140.32
17_A313_V0.5130.31
36_L39_G0.5080.31
25_M30_K0.5070.31
248_K264_A0.5060.31
67_A302_G0.5040.31
168_K194_V0.5030.31
98_Y288_G0.5030.31
301_S305_A0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1musA 2 0.9266 99.9 0.717 Contact Map
2kkoA 2 0.3023 24.6 0.963 Contact Map
2zkzA 2 0.2514 10 0.969 Contact Map
3cuoA 2 0.2768 9.2 0.97 Contact Map
3rqiA 2 0.1723 8 0.97 Contact Map
3hdeA 2 0.2825 7.6 0.971 Contact Map
1qgpA 1 0.2034 7.2 0.971 Contact Map
1r1tA 2 0.274 7 0.971 Contact Map
4i2oA 2 0.2486 6.4 0.972 Contact Map
3mzyA 1 0.209 6.2 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0103 seconds.