GREMLIN Database
Q97ZD7 - Pyruvate kinase
UniProt: Q97ZD7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 452 (445)
Sequences: 4105 (2314)
Seq/√Len: 109.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_K53_E4.4361.00
198_A216_S4.4291.00
119_K129_T4.4191.00
210_T245_T4.1201.00
41_R45_D3.4561.00
209_L242_I3.4371.00
184_K215_E3.2441.00
117_R129_T3.2111.00
8_A25_V3.1911.00
58_V164_A3.0741.00
206_L238_I2.9531.00
255_L285_V2.9321.00
234_N313_N2.8711.00
25_V28_F2.8621.00
183_V198_A2.8461.00
187_K196_V2.8111.00
55_S385_K2.7741.00
117_R131_I2.7311.00
120_S127_E2.6181.00
17_K20_E2.5841.00
41_R167_L2.5361.00
81_K127_E2.4941.00
77_K80_D2.4671.00
69_E139_R2.4381.00
39_S43_Y2.4021.00
81_K119_K2.3841.00
183_V196_V2.3471.00
82_I90_I2.3281.00
233_E309_N2.3101.00
214_N249_F2.3081.00
15_E43_Y2.2761.00
161_L172_I2.2421.00
23_E54_S2.2221.00
375_S381_A2.2131.00
265_N298_N2.2001.00
181_N185_K2.1991.00
347_D423_K2.1421.00
44_F167_L2.1191.00
230_T238_I2.1161.00
240_R283_Q2.0881.00
197_I218_G2.0521.00
96_L99_S2.0221.00
109_I136_L2.0101.00
308_H312_S1.9831.00
288_I311_I1.9691.00
17_K301_V1.9401.00
168_G379_R1.9351.00
165_L194_A1.9141.00
81_K129_T1.8911.00
76_V130_V1.8711.00
195_W383_K1.8691.00
48_R51_A1.8691.00
103_E121_K1.8581.00
44_F56_I1.8291.00
209_L213_V1.8151.00
73_P135_I1.8141.00
243_V255_L1.7881.00
106_D115_R1.7821.00
158_L162_K1.7781.00
30_I44_F1.7781.00
350_V425_I1.7761.00
116_V128_G1.7721.00
100_A150_K1.7571.00
82_I128_G1.7561.00
84_F116_V1.7461.00
19_K23_E1.7461.00
340_A442_V1.7301.00
75_E135_I1.7281.00
156_N160_L1.7271.00
60_L64_K1.7221.00
83_V127_E1.7201.00
411_K415_E1.7161.00
181_N184_K1.7071.00
219_I242_I1.7051.00
155_D159_K1.6981.00
381_A394_S1.6961.00
174_L186_V1.6791.00
148_N204_E1.6781.00
7_V254_I1.6691.00
80_D130_V1.6671.00
10_L18_V1.6671.00
203_S207_K1.6541.00
180_E211_N1.6391.00
22_A50_Y1.6271.00
188_E192_D1.6211.00
38_T41_R1.6131.00
83_V125_R1.6061.00
27_V57_I1.6041.00
241_R245_T1.5931.00
302_E305_R1.5921.00
20_E23_E1.5721.00
28_F47_I1.5621.00
70_L138_S1.5581.00
7_V27_V1.5421.00
122_A125_R1.5401.00
50_Y54_S1.5381.00
158_L185_K1.5371.00
106_D117_R1.5221.00
197_I254_I1.5171.00
19_K54_S1.5051.00
58_V169_A1.4891.00
2_R308_H1.4861.00
384_F387_C1.4761.00
159_K162_K1.4751.00
299_Y302_E1.4741.00
49_T53_E1.4661.00
412_L415_E1.4601.00
98_Y126_V1.4571.00
87_K124_D1.4561.00
264_I292_D1.4551.00
102_K105_S1.4531.00
35_G40_H1.4301.00
17_K21_L1.4181.00
56_I169_A1.4181.00
346_A426_V1.4091.00
42_K45_D1.4031.00
41_R166_D1.3831.00
235_L275_I1.3751.00
121_K126_V1.3661.00
105_S147_V1.3651.00
37_E163_R1.3641.00
36_D39_S1.3601.00
164_A169_A1.3601.00
110_A113_T1.3461.00
305_R309_N1.3451.00
232_L306_T1.3441.00
42_K46_L1.3381.00
67_L114_I1.3381.00
30_I47_I1.3331.00
158_L189_F1.3281.00
412_L416_K1.3261.00
245_T249_F1.3240.99
208_N211_N1.3220.99
353_S373_G1.3190.99
8_A28_F1.3170.99
281_I311_I1.3130.99
122_A127_E1.3030.99
87_K125_R1.2950.99
193_E379_R1.2950.99
10_L43_Y1.2930.99
202_K205_A1.2840.99
261_T265_N1.2820.99
85_S125_R1.2790.99
14_S17_K1.2700.99
165_L190_V1.2660.99
414_Q421_K1.2590.99
16_E19_K1.2570.99
180_E215_E1.2550.99
101_V126_V1.2550.99
373_G384_F1.2530.99
109_I116_V1.2510.99
67_L90_I1.2450.99
20_E305_R1.2330.99
21_L304_V1.2300.99
68_G91_P1.2290.99
213_V245_T1.2290.99
313_N316_K1.2240.99
19_K50_Y1.2170.99
78_K133_G1.2170.99
46_L49_T1.2150.99
40_H43_Y1.2070.99
238_I242_I1.2030.99
30_I169_A1.2030.99
45_D49_T1.1920.99
86_Q98_Y1.1920.99
184_K188_E1.1870.99
88_D95_E1.1860.99
46_L50_Y1.1790.99
77_K133_G1.1790.99
4_T311_I1.1790.99
329_E424_K1.1760.99
86_Q89_G1.1750.99
243_V285_V1.1710.99
180_E184_K1.1700.99
162_K166_D1.1640.99
332_A340_A1.1630.99
15_E46_L1.1500.99
373_G390_V1.1390.98
73_P137_L1.1300.98
401_S404_E1.1280.98
37_E160_L1.1260.98
52_P378_P1.1240.98
95_E98_Y1.1240.98
144_I147_V1.1230.98
10_L14_S1.1210.98
74_I136_L1.1100.98
61_P64_K1.1080.98
44_F163_R1.1080.98
424_K446_T1.1060.98
15_E42_K1.1060.98
115_R131_I1.1020.98
96_L100_A1.0990.98
30_I56_I1.0910.98
340_A444_V1.0880.98
360_L387_C1.0850.98
429_G441_F1.0810.98
348_V372_I1.0780.98
261_T264_I1.0770.98
237_L282_M1.0720.98
32_F58_V1.0700.98
130_V133_G1.0690.98
84_F92_V1.0670.98
14_S21_L1.0630.98
259_V277_I1.0570.98
331_D364_R1.0570.98
277_I310_I1.0570.98
267_P299_Y1.0470.97
261_T292_D1.0440.97
116_V130_V1.0380.97
180_E208_N1.0370.97
162_K192_D1.0340.97
4_T281_I1.0240.97
185_K188_E1.0230.97
81_K120_S1.0190.97
69_E138_S1.0170.97
170_D382_K1.0160.97
335_L339_N1.0140.97
10_L47_I1.0100.97
47_I56_I1.0080.97
98_Y121_K1.0060.97
274_I310_I1.0060.97
351_V362_V1.0050.97
187_K217_D1.0020.97
70_L82_I1.0010.97
190_V194_A1.0000.97
178_I204_E0.9990.97
119_K127_E0.9980.96
419_D447_L0.9930.96
67_L137_L0.9880.96
20_E301_V0.9840.96
110_A137_L0.9820.96
161_L186_V0.9790.96
144_I149_L0.9790.96
7_V287_S0.9780.96
27_V287_S0.9770.96
216_S219_I0.9730.96
39_S42_K0.9720.96
109_I128_G0.9700.96
232_L274_I0.9700.96
44_F169_A0.9690.96
64_K202_K0.9670.96
45_D167_L0.9630.96
209_L245_T0.9630.96
372_I413_M0.9580.96
374_V395_I0.9570.96
153_I158_L0.9520.95
363_S387_C0.9520.95
78_K298_N0.9480.95
41_R163_R0.9480.95
85_S89_G0.9460.95
61_P156_N0.9400.95
429_G432_P0.9400.95
90_I136_L0.9390.95
57_I173_G0.9370.95
179_S182_D0.9350.95
115_R268_I0.9350.95
169_A194_A0.9350.95
206_L226_L0.9350.95
50_Y53_E0.9330.95
347_D420_L0.9280.95
210_T213_V0.9280.95
92_V142_I0.9260.95
75_E133_G0.9240.95
18_V50_Y0.9220.95
155_D158_L0.9210.95
61_P160_L0.9190.94
84_F128_G0.9160.94
79_G129_T0.9150.94
94_D100_A0.9150.94
97_F126_V0.9150.94
171_Y197_I0.9140.94
70_L136_L0.9090.94
158_L188_E0.9080.94
299_Y303_S0.9070.94
301_V305_R0.9010.94
106_D131_I0.8970.94
213_V249_F0.8970.94
260_L303_S0.8960.94
203_S234_N0.8920.94
84_F107_I0.8900.93
210_T249_F0.8900.93
333_I428_V0.8820.93
38_T42_K0.8810.93
213_V246_S0.8780.93
58_V64_K0.8720.93
14_S294_T0.8720.93
110_A261_T0.8710.93
70_L137_L0.8670.93
143_N229_E0.8610.92
162_K165_L0.8600.92
244_R248_V0.8580.92
165_L172_I0.8570.92
406_I427_I0.8410.91
277_I288_I0.8370.91
282_M317_S0.8370.91
37_E41_R0.8360.91
161_L189_F0.8330.91
334_A362_V0.8310.91
22_A54_S0.8300.91
183_V216_S0.8300.91
22_A51_A0.8270.91
119_K128_G0.8250.91
209_L241_R0.8240.91
101_V107_I0.8230.90
10_L30_I0.8210.90
110_A292_D0.8140.90
211_N214_N0.8140.90
237_L314_V0.8130.90
64_K141_G0.8120.90
243_V253_V0.8120.90
96_L150_K0.8090.90
375_S394_S0.8090.90
55_S171_Y0.8090.90
432_P440_N0.8060.90
360_L383_K0.8060.90
105_S118_V0.8060.90
67_L142_I0.8010.89
103_E119_K0.7990.89
341_S349_I0.7970.89
339_N343_V0.7960.89
74_I90_I0.7940.89
410_A425_I0.7930.89
335_L343_V0.7920.89
102_K121_K0.7920.89
359_I373_G0.7900.89
33_A160_L0.7870.88
18_V47_I0.7860.88
104_N117_R0.7850.88
111_D258_Q0.7840.88
380_L384_F0.7830.88
259_V307_L0.7810.88
379_R383_K0.7790.88
84_F90_I0.7780.88
163_R167_L0.7760.88
197_I386_L0.7760.88
209_L246_S0.7760.88
18_V46_L0.7730.87
70_L90_I0.7720.87
17_K46_L0.7720.87
49_T52_P0.7710.87
333_I442_V0.7710.87
78_K129_T0.7680.87
60_L202_K0.7660.87
378_P394_S0.7630.87
51_A54_S0.7620.87
103_E120_S0.7620.87
27_V55_S0.7610.87
413_M419_D0.7580.86
378_P382_K0.7580.86
64_K205_A0.7570.86
351_V358_S0.7560.86
162_K189_F0.7540.86
111_D141_G0.7530.86
19_K49_T0.7520.86
330_S357_N0.7520.86
110_A141_G0.7510.86
164_A172_I0.7500.86
114_I130_V0.7490.86
348_V419_D0.7480.86
213_V242_I0.7480.86
357_N361_R0.7460.86
218_G252_P0.7440.85
259_V288_I0.7420.85
346_A444_V0.7410.85
55_S382_K0.7360.85
331_D361_R0.7350.85
410_A445_K0.7340.85
145_P229_E0.7320.85
47_I51_A0.7320.85
22_A47_I0.7300.84
227_G268_I0.7300.84
186_V196_V0.7270.84
406_I443_I0.7250.84
146_N203_S0.7240.84
353_S359_I0.7240.84
337_A341_S0.7220.84
247_R286_D0.7210.84
337_A428_V0.7210.84
313_N317_S0.7190.83
200_I206_L0.7180.83
92_V96_L0.7180.83
10_L46_L0.7170.83
76_V114_I0.7140.83
344_S424_K0.7140.83
200_I209_L0.7120.83
67_L70_L0.7110.83
351_V359_I0.7110.83
32_F160_L0.7090.83
279_N283_Q0.7090.83
374_V413_M0.7070.82
14_S301_V0.7050.82
10_L28_F0.7040.82
171_Y387_C0.7040.82
427_I445_K0.7020.82
98_Y124_D0.7020.82
337_A426_V0.7010.82
37_E159_K0.7010.82
296_I303_S0.7000.82
44_F47_I0.7000.82
231_G235_L0.7000.82
189_F192_D0.6990.82
70_L114_I0.6970.82
15_E18_V0.6950.81
60_L174_L0.6910.81
7_V25_V0.6900.81
308_H311_I0.6880.81
238_I241_R0.6870.81
385_K392_P0.6870.81
113_T266_S0.6860.80
83_V122_A0.6860.80
6_I304_V0.6850.80
2_R26_D0.6830.80
32_F40_H0.6820.80
354_R377_D0.6820.80
137_L296_I0.6800.80
152_G177_V0.6800.80
377_D380_L0.6800.80
68_G93_D0.6790.80
235_L274_I0.6760.80
220_M291_S0.6740.79
354_R397_K0.6740.79
114_I134_G0.6740.79
205_A213_V0.6730.79
188_E191_G0.6730.79
282_M318_V0.6720.79
350_V419_D0.6720.79
36_D139_R0.6710.79
10_L15_E0.6710.79
237_L317_S0.6680.79
94_D97_F0.6680.79
114_I136_L0.6670.79
210_T241_R0.6660.79
371_I390_V0.6620.78
30_I40_H0.6610.78
80_D116_V0.6600.78
337_A349_I0.6600.78
252_P386_L0.6590.78
172_I190_V0.6590.78
354_R376_P0.6570.78
82_I91_P0.6560.77
381_A392_P0.6560.77
15_E39_S0.6550.77
6_I307_L0.6550.77
73_P138_S0.6540.77
61_P292_D0.6530.77
34_H225_D0.6500.77
240_R279_N0.6500.77
35_G39_S0.6500.77
282_M314_V0.6490.77
250_G367_P0.6480.77
214_N251_K0.6460.76
171_Y386_L0.6440.76
414_Q419_D0.6430.76
82_I137_L0.6430.76
294_T303_S0.6400.76
338_V367_P0.6400.76
411_K414_Q0.6370.75
340_A344_S0.6360.75
366_R388_Y0.6350.75
136_L139_R0.6350.75
180_E200_I0.6340.75
164_A168_G0.6340.75
114_I133_G0.6320.75
426_V444_V0.6310.75
187_K191_G0.6310.75
281_I288_I0.6280.74
18_V21_L0.6260.74
40_H164_A0.6260.74
209_L219_I0.6260.74
76_V80_D0.6250.74
10_L25_V0.6250.74
31_N34_H0.6240.74
330_S361_R0.6240.74
410_A447_L0.6240.74
181_N211_N0.6240.74
27_V385_K0.6230.74
260_L306_T0.6230.74
434_Q437_G0.6210.74
2_R275_I0.6200.73
259_V291_S0.6190.73
99_S150_K0.6190.73
101_V118_V0.6190.73
250_G364_R0.6180.73
245_T248_V0.6170.73
21_L28_F0.6170.73
420_L423_K0.6170.73
358_S430_G0.6160.73
200_I242_I0.6160.73
43_Y46_L0.6150.73
21_L301_V0.6120.72
153_I161_L0.6120.72
83_V124_D0.6120.72
186_V189_F0.6120.72
431_D443_I0.6110.72
100_A178_I0.6100.72
428_V439_T0.6100.72
84_F97_F0.6090.72
328_S331_D0.6090.72
399_M408_V0.6080.72
241_R317_S0.6060.72
195_W360_L0.6060.72
399_M405_I0.6060.72
179_S208_N0.6060.72
84_F109_I0.6060.72
85_S98_Y0.6050.72
70_L73_P0.6040.71
306_T310_I0.6030.71
348_V370_N0.6030.71
65_L142_I0.6020.71
237_L313_N0.6010.71
61_P202_K0.6010.71
179_S211_N0.6000.71
359_I392_P0.6000.71
437_G440_N0.6000.71
44_F48_R0.5980.71
252_P286_D0.5970.71
135_I265_N0.5950.70
176_F225_D0.5950.70
78_K299_Y0.5940.70
236_P388_Y0.5940.70
58_V163_R0.5930.70
99_S124_D0.5930.70
168_G194_A0.5920.70
329_E351_V0.5910.70
306_T309_N0.5910.70
410_A419_D0.5900.70
82_I130_V0.5900.70
281_I314_V0.5890.70
153_I189_F0.5870.69
65_L156_N0.5870.69
185_K189_F0.5870.69
23_E53_E0.5860.69
399_M404_E0.5860.69
341_S346_A0.5850.69
318_V323_I0.5850.69
190_V195_W0.5840.69
294_T307_L0.5790.68
220_M289_M0.5790.68
21_L25_V0.5770.68
110_A140_K0.5770.68
94_D178_I0.5760.68
67_L84_F0.5760.68
344_S444_V0.5760.68
217_D251_K0.5750.68
391_I418_K0.5740.68
171_Y195_W0.5730.67
72_E138_S0.5720.67
76_V82_I0.5720.67
426_V442_V0.5720.67
177_V198_A0.5710.67
152_G178_I0.5710.67
2_R6_I0.5710.67
60_L141_G0.5710.67
337_A346_A0.5700.67
342_K368_E0.5700.67
176_F229_E0.5690.67
33_A58_V0.5690.67
247_R255_L0.5690.67
434_Q439_T0.5670.67
254_I289_M0.5670.67
344_S426_V0.5670.67
352_Y405_I0.5670.67
232_L275_I0.5660.67
430_G439_T0.5660.67
67_L140_K0.5620.66
367_P371_I0.5620.66
372_I418_K0.5620.66
76_V109_I0.5610.66
198_A219_I0.5590.66
153_I186_V0.5590.66
61_P205_A0.5580.65
16_E46_L0.5580.65
302_E306_T0.5560.65
98_Y123_K0.5550.65
51_A382_K0.5550.65
6_I308_H0.5540.65
408_V411_K0.5540.65
374_V393_I0.5510.64
200_I218_G0.5510.64
373_G392_P0.5510.64
99_S121_K0.5510.64
57_I171_Y0.5500.64
105_S146_N0.5500.64
32_F169_A0.5500.64
111_D295_A0.5500.64
219_I249_F0.5500.64
402_I441_F0.5480.64
440_N443_I0.5470.64
288_I308_H0.5470.64
92_V144_I0.5470.64
361_R406_I0.5460.64
143_N154_T0.5440.64
234_N309_N0.5430.63
174_L177_V0.5430.63
80_D133_G0.5420.63
375_S380_L0.5410.63
106_D146_N0.5400.63
41_R44_F0.5400.63
259_V285_V0.5400.63
67_L136_L0.5390.63
362_V428_V0.5390.63
287_S386_L0.5380.63
181_N188_E0.5380.63
57_I287_S0.5370.63
83_V86_Q0.5360.62
26_D385_K0.5350.62
110_A178_I0.5350.62
115_R132_E0.5350.62
10_L56_I0.5340.62
220_M256_A0.5340.62
45_D166_D0.5330.62
36_D159_K0.5330.62
278_S282_M0.5330.62
364_R437_G0.5320.62
98_Y101_V0.5310.62
16_E20_E0.5310.62
137_L140_K0.5310.62
93_D138_S0.5290.61
171_Y287_S0.5290.61
328_S361_R0.5280.61
151_S185_K0.5280.61
81_K117_R0.5270.61
30_I35_G0.5270.61
237_L274_I0.5260.61
108_L173_G0.5250.61
176_F220_M0.5240.61
430_G437_G0.5230.61
351_V373_G0.5230.61
94_D98_Y0.5220.60
240_R282_M0.5210.60
356_G373_G0.5200.60
109_I114_I0.5200.60
74_I80_D0.5200.60
350_V374_V0.5190.60
141_G228_V0.5160.59
107_I126_V0.5160.59
187_K215_E0.5160.59
225_D256_A0.5160.59
297_G300_P0.5140.59
402_I429_G0.5130.59
141_G229_E0.5130.59
363_S371_I0.5120.59
407_D411_K0.5120.59
380_L430_G0.5110.59
76_V136_L0.5110.59
261_T277_I0.5110.59
329_E444_V0.5100.59
68_G138_S0.5090.58
340_A426_V0.5090.58
14_S46_L0.5090.58
111_D225_D0.5090.58
58_V174_L0.5080.58
119_K122_A0.5080.58
14_S296_I0.5070.58
218_G386_L0.5070.58
247_R284_G0.5060.58
388_Y429_G0.5050.58
82_I85_S0.5050.58
220_M259_V0.5050.58
141_G178_I0.5050.58
68_G85_S0.5050.58
236_P275_I0.5050.58
213_V251_K0.5030.58
32_F37_E0.5020.57
348_V425_I0.5020.57
281_I331_D0.5010.57
230_T234_N0.5000.57
92_V97_F0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gr4A 4 0.9889 100 0.16 Contact Map
2e28A 3 0.9978 100 0.165 Contact Map
1a3wA 3 0.9823 100 0.167 Contact Map
3gg8A 3 0.9845 100 0.168 Contact Map
3t05A 3 0.9956 100 0.169 Contact Map
3khdA 3 0.9889 100 0.172 Contact Map
1e0tA 3 0.9358 100 0.174 Contact Map
4kctB 3 0.9889 100 0.192 Contact Map
4drsA 3 0.9668 100 0.202 Contact Map
3qtgA 3 0.9491 100 0.204 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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