GREMLIN Database
Q97ZD5 - Oxidoreductase, putative
UniProt: Q97ZD5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 365 (356)
Sequences: 3901 (2765)
Seq/√Len: 146.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
153_P156_E5.7281.00
188_I192_I5.0781.00
136_S140_E3.5591.00
4_G213_Y3.5351.00
24_I350_L3.4321.00
347_D352_K3.3401.00
327_V341_M3.3321.00
20_A192_I3.3081.00
21_K118_E3.1821.00
31_E198_E3.0581.00
76_E80_L2.9491.00
157_I166_G2.9441.00
4_G29_I2.8351.00
6_V220_A2.8341.00
150_P156_E2.7391.00
325_V345_A2.7391.00
347_D355_D2.6291.00
22_E352_K2.6221.00
148_K171_E2.6151.00
8_G30_Y2.6051.00
186_R189_V2.6001.00
224_S328_T2.5671.00
325_V349_A2.5261.00
156_E159_E2.4621.00
22_E350_L2.4371.00
113_K126_E2.4041.00
18_Y342_G2.2871.00
285_E289_K2.1751.00
90_E93_P2.1491.00
327_V345_A2.0961.00
15_T327_V2.0811.00
3_V24_I2.0591.00
186_R190_S2.0511.00
20_A188_I2.0471.00
152_N156_E2.0181.00
111_E343_R1.9961.00
330_A341_M1.9471.00
150_P170_P1.9331.00
27_I195_K1.8771.00
8_G34_F1.8421.00
25_K193_K1.8211.00
187_E190_S1.7971.00
14_F342_G1.7811.00
178_E182_D1.7781.00
213_Y216_V1.7621.00
13_L28_I1.7481.00
143_I147_K1.7401.00
140_E143_I1.7271.00
15_T217_V1.7191.00
236_G308_R1.7181.00
321_R326_L1.7051.00
114_R118_E1.6931.00
216_V323_N1.6901.00
179_K183_R1.6891.00
93_P96_E1.6881.00
247_L250_A1.6841.00
185_S194_V1.6831.00
342_G346_T1.6711.00
154_K158_E1.6671.00
13_L181_I1.6191.00
32_K36_G1.6141.00
325_V348_L1.6061.00
269_I291_A1.6001.00
215_L325_V1.5991.00
107_F343_R1.5871.00
29_I213_Y1.5741.00
83_V87_K1.5381.00
30_Y33_G1.5231.00
343_R347_D1.5191.00
288_L292_E1.5181.00
103_E361_R1.4721.00
320_K323_N1.4631.00
17_Y21_K1.4611.00
150_P168_F1.4551.00
22_E346_T1.4521.00
249_R252_V1.4491.00
150_P160_I1.4481.00
295_V298_Q1.4441.00
32_K37_A1.4261.00
88_N93_P1.4121.00
13_L188_I1.4091.00
281_S285_E1.4081.00
152_N160_I1.3981.00
338_G342_G1.3901.00
27_I193_K1.3811.00
234_F310_C1.3781.00
91_K95_G1.3601.00
268_K271_G1.3441.00
111_E114_R1.3261.00
205_E212_K1.3241.00
100_T361_R1.3241.00
18_Y22_E1.3161.00
18_Y343_R1.3161.00
175_I335_W1.3131.00
17_Y187_E1.3091.00
3_V215_L1.3051.00
100_T315_F1.3031.00
208_I323_N1.3011.00
219_A327_V1.3011.00
189_V194_V1.2891.00
231_L328_T1.2881.00
185_S189_V1.2761.00
33_G36_G1.2741.00
284_A288_L1.2731.00
333_L336_S1.2701.00
138_E255_D1.2521.00
357_G360_S1.2521.00
123_D179_K1.2511.00
347_D354_K1.2481.00
84_E87_K1.2421.00
87_K90_E1.2381.00
10_I338_G1.2251.00
233_A307_F1.2221.00
108_S340_A1.2191.00
311_S317_V1.2191.00
139_F142_G1.2101.00
139_F151_F1.2071.00
217_V349_A1.2021.00
28_I194_V1.1991.00
27_I214_D1.1981.00
144_E147_K1.1971.00
180_F335_W1.1851.00
142_G146_E1.1791.00
41_H304_N1.1701.00
15_T219_A1.1641.00
6_V199_V1.1531.00
346_T350_L1.1521.00
24_I349_A1.1521.00
119_K187_E1.1501.00
157_I163_F1.1471.00
197_E209_D1.1461.00
344_Y358_Y1.1451.00
204_D323_N1.1370.99
320_K325_V1.1350.99
14_F339_P1.1330.99
18_Y115_I1.1300.99
217_V345_A1.1300.99
207_Y212_K1.1290.99
272_G283_R1.1270.99
253_I256_Y1.1250.99
343_R355_D1.1240.99
111_E340_A1.1210.99
354_K358_Y1.1200.99
114_R343_R1.1170.99
162_G293_E1.1170.99
236_G309_P1.1000.99
61_K65_K1.0960.99
218_V324_L1.0940.99
59_M62_K1.0930.99
320_K348_L1.0930.99
234_F273_F1.0920.99
284_A303_L1.0900.99
71_S289_K1.0810.99
40_I178_E1.0800.99
212_K216_V1.0790.99
208_I216_V1.0790.99
20_A25_K1.0780.99
183_R186_R1.0770.99
105_A337_Y1.0740.99
155_F159_E1.0660.99
31_E37_A1.0600.99
289_K293_E1.0580.99
215_L320_K1.0570.99
44_G263_L1.0550.99
208_I324_L1.0540.99
40_I302_D1.0540.99
133_Y139_F1.0500.99
83_V86_I1.0450.99
176_S264_S1.0440.99
28_I192_I1.0440.99
256_Y293_E1.0430.99
24_I214_D1.0420.99
95_G99_D1.0350.99
220_A224_S1.0350.99
107_F340_A1.0320.99
96_E99_D1.0260.99
143_I151_F1.0240.99
175_I180_F1.0190.99
247_L252_V1.0180.99
66_Y73_D1.0090.99
160_I249_R1.0070.99
199_V220_A1.0040.99
241_V288_L1.0000.99
246_K250_A0.9920.99
148_K170_P0.9910.99
176_S179_K0.9870.99
29_I195_K0.9870.99
237_Y274_D0.9850.99
135_N138_E0.9820.98
113_K173_S0.9810.98
189_V193_K0.9800.98
69_N72_T0.9770.98
268_K274_D0.9730.98
179_K182_D0.9720.98
18_Y21_K0.9710.98
18_Y111_E0.9670.98
81_W85_L0.9670.98
136_S164_A0.9670.98
60_I86_I0.9500.98
220_A227_L0.9490.98
215_L349_A0.9480.98
132_L163_F0.9440.98
348_L354_K0.9420.98
60_I64_L0.9380.98
232_T307_F0.9370.98
110_S114_R0.9300.98
53_K73_D0.9270.98
36_G182_D0.9250.98
142_G145_D0.9210.98
72_T75_K0.9150.98
316_P337_Y0.9130.98
24_I27_I0.9130.98
345_A349_A0.9110.98
240_R266_H0.9080.97
112_Y338_G0.9070.97
201_K204_D0.9060.97
318_I361_R0.8990.97
207_Y323_N0.8980.97
203_S211_E0.8980.97
289_K292_E0.8980.97
128_G168_F0.8960.97
24_I215_L0.8950.97
169_F172_L0.8940.97
4_G216_V0.8930.97
22_E343_R0.8910.97
107_F111_E0.8900.97
309_P330_A0.8860.97
10_I181_I0.8850.97
285_E288_L0.8840.97
225_R228_K0.8830.97
235_K305_M0.8810.97
160_I168_F0.8770.97
202_V216_V0.8770.97
188_I194_V0.8770.97
62_K66_Y0.8700.97
356_L361_R0.8660.97
64_L68_M0.8640.97
154_K163_F0.8600.96
134_Y253_I0.8600.96
271_G274_D0.8590.96
64_L67_K0.8570.96
45_L50_R0.8560.96
344_Y347_D0.8560.96
214_D323_N0.8550.96
116_A122_F0.8540.96
63_M66_Y0.8540.96
15_T22_E0.8530.96
181_I185_S0.8520.96
103_E360_S0.8510.96
152_N157_I0.8510.96
318_I341_M0.8480.96
102_R106_K0.8470.96
247_L251_A0.8430.96
20_A28_I0.8410.96
179_K264_S0.8390.96
30_Y34_F0.8370.96
29_I197_E0.8350.96
107_F110_S0.8340.96
318_I345_A0.8330.96
268_K273_F0.8300.96
229_I328_T0.8270.96
34_F182_D0.8260.96
188_I191_N0.8250.96
239_Y301_I0.8230.95
286_D290_K0.8210.95
14_F338_G0.8180.95
60_I89_L0.8150.95
30_Y194_V0.8130.95
234_F272_G0.8090.95
122_F183_R0.8080.95
64_L69_N0.8040.95
230_P317_V0.8020.95
340_A344_Y0.8000.95
230_P313_D0.7990.95
217_V325_V0.7980.95
134_Y162_G0.7940.95
292_E297_I0.7920.94
28_I185_S0.7890.94
268_K272_G0.7860.94
58_S63_M0.7840.94
207_Y322_N0.7810.94
133_Y142_G0.7770.94
218_V224_S0.7740.94
330_A334_G0.7730.94
189_V212_K0.7690.94
139_F143_I0.7690.94
114_R117_E0.7680.93
311_S329_G0.7670.93
204_D324_L0.7660.93
246_K252_V0.7640.93
94_P98_W0.7570.93
141_S144_E0.7570.93
151_F167_L0.7560.93
288_L303_L0.7540.93
38_G222_I0.7520.93
13_L185_S0.7510.93
135_N255_D0.7500.93
88_N97_A0.7490.93
182_D186_R0.7470.93
116_A173_S0.7440.92
104_M340_A0.7420.92
127_D248_N0.7380.92
177_T180_F0.7370.92
198_E226_I0.7280.92
7_G12_G0.7280.92
19_L349_A0.7270.92
235_K278_S0.7260.91
242_K301_I0.7250.91
5_I217_V0.7240.91
149_S167_L0.7210.91
246_K249_R0.7210.91
123_D266_H0.7190.91
33_G196_N0.7120.91
308_R330_A0.7120.91
63_M82_L0.7090.90
239_Y288_L0.7080.90
311_S331_C0.7070.90
288_L291_A0.7060.90
49_Y52_D0.7050.90
47_E50_R0.7040.90
318_I360_S0.7040.90
288_L299_Y0.7040.90
66_Y74_I0.7020.90
9_G12_G0.7010.90
285_E303_L0.7000.90
36_G40_I0.6990.90
235_K276_D0.6990.90
234_F332_R0.6940.90
257_G271_G0.6930.89
354_K357_G0.6900.89
200_I203_S0.6890.89
140_E144_E0.6870.89
16_A28_I0.6860.89
309_P329_G0.6830.89
222_I233_A0.6780.88
50_R173_S0.6770.88
218_V227_L0.6760.88
237_Y283_R0.6750.88
200_I209_D0.6730.88
128_G170_P0.6720.88
3_V19_L0.6660.88
14_F28_I0.6660.88
242_K299_Y0.6660.88
161_K249_R0.6650.87
143_I146_E0.6640.87
31_E223_W0.6630.87
6_V202_V0.6620.87
161_K248_N0.6610.87
62_K65_K0.6610.87
327_V330_A0.6590.87
41_H238_G0.6590.87
92_D96_E0.6570.87
5_I12_G0.6560.87
113_K117_E0.6540.87
174_R261_S0.6540.87
112_Y180_F0.6520.86
244_V298_Q0.6500.86
49_Y259_A0.6490.86
136_S143_I0.6490.86
100_T360_S0.6490.86
99_D103_E0.6470.86
319_G348_L0.6470.86
224_S326_L0.6450.86
15_T75_K0.6450.86
20_A187_E0.6390.85
155_F158_E0.6370.85
45_L259_A0.6360.85
215_L323_N0.6360.85
269_I287_F0.6350.85
308_R332_R0.6350.85
14_F115_I0.6330.85
5_I8_G0.6320.85
121_D179_K0.6300.85
63_M67_K0.6300.85
113_K124_Y0.6290.84
348_L358_Y0.6280.84
222_I307_F0.6280.84
154_K157_I0.6250.84
4_G27_I0.6220.84
271_G283_R0.6210.84
46_I173_S0.6190.83
112_Y339_P0.6170.83
230_P311_S0.6170.83
3_V350_L0.6170.83
310_C331_C0.6160.83
290_K293_E0.6160.83
281_S303_L0.6140.83
139_F165_G0.6110.83
319_G344_Y0.6100.83
281_S284_A0.6080.82
258_L261_S0.6070.82
199_V216_V0.6070.82
141_S146_E0.6050.82
202_V208_I0.6050.82
259_A270_T0.6040.82
282_K286_D0.6030.82
153_P160_I0.6020.82
272_G308_R0.6020.82
130_L166_G0.6010.82
174_R262_P0.6000.82
50_R55_N0.6000.82
5_I195_K0.5990.81
156_E160_I0.5980.81
36_G178_E0.5980.81
221_G237_Y0.5970.81
178_E181_I0.5950.81
86_I89_L0.5950.81
101_M337_Y0.5940.81
19_L24_I0.5920.81
11_V14_F0.5900.80
258_L290_K0.5900.80
237_Y268_K0.5890.80
333_L337_Y0.5890.80
310_C332_R0.5880.80
42_A304_N0.5880.80
23_G26_D0.5870.80
69_N75_K0.5860.80
181_I188_I0.5850.80
66_Y71_S0.5840.80
142_G147_K0.5840.80
197_E210_G0.5830.80
43_A259_A0.5830.80
75_K82_L0.5820.80
340_A356_L0.5810.79
17_Y20_A0.5810.79
239_Y287_F0.5800.79
56_T59_M0.5790.79
45_L66_Y0.5790.79
33_G182_D0.5760.79
137_K140_E0.5760.79
65_K70_G0.5760.79
69_N73_D0.5760.79
204_D322_N0.5760.79
115_I119_K0.5750.79
107_F356_L0.5740.79
231_L309_P0.5720.78
56_T94_P0.5720.78
107_F355_D0.5710.78
177_T223_W0.5690.78
10_I14_F0.5690.78
124_Y173_S0.5680.78
61_K64_L0.5680.78
59_M66_Y0.5670.78
8_G35_L0.5660.78
34_F185_S0.5660.78
189_V195_K0.5650.78
308_R336_S0.5620.77
125_H174_R0.5620.77
269_I273_F0.5620.77
270_T273_F0.5620.77
15_T18_Y0.5590.77
13_L54_I0.5580.77
272_G287_F0.5580.77
241_V244_V0.5580.77
327_V342_G0.5570.77
223_W276_D0.5570.77
317_V328_T0.5560.76
266_H271_G0.5550.76
56_T72_T0.5540.76
130_L133_Y0.5530.76
278_S282_K0.5530.76
61_K68_M0.5520.76
356_L360_S0.5520.76
48_P336_S0.5520.76
177_T335_W0.5510.76
248_N252_V0.5500.76
241_V300_I0.5490.76
59_M85_L0.5490.76
155_F206_G0.5470.75
178_E339_P0.5460.75
112_Y258_L0.5440.75
176_S336_S0.5440.75
224_S231_L0.5420.75
89_L93_P0.5410.74
70_G282_K0.5410.74
63_M75_K0.5410.74
42_A53_K0.5400.74
59_M73_D0.5390.74
269_I272_G0.5380.74
5_I20_A0.5380.74
315_F360_S0.5370.74
159_E297_I0.5370.74
15_T349_A0.5360.74
45_L252_V0.5360.74
101_M333_L0.5350.74
21_K61_K0.5330.73
185_S192_I0.5330.73
321_R324_L0.5310.73
273_F332_R0.5310.73
290_K294_L0.5300.73
34_F37_A0.5300.73
267_I270_T0.5290.73
123_D263_L0.5290.73
204_D208_I0.5290.73
155_F162_G0.5280.73
293_E296_D0.5280.73
279_I284_A0.5270.73
152_N161_K0.5270.73
280_D283_R0.5250.72
330_A337_Y0.5250.72
50_R333_L0.5250.72
180_F339_P0.5250.72
284_A291_A0.5240.72
154_K160_I0.5230.72
17_Y188_I0.5220.72
51_F55_N0.5200.72
17_Y119_K0.5200.72
126_E171_E0.5200.72
246_K251_A0.5200.72
103_E106_K0.5200.72
31_E36_G0.5190.71
81_W101_M0.5190.71
108_S111_E0.5180.71
29_I70_G0.5180.71
52_D56_T0.5180.71
110_S113_K0.5170.71
132_L138_E0.5150.71
304_N334_G0.5150.71
50_R131_E0.5130.71
80_L84_E0.5130.71
267_I271_G0.5130.71
180_F338_G0.5130.71
136_S165_G0.5130.71
36_G41_H0.5110.70
243_G246_K0.5110.70
62_K71_S0.5100.70
53_K72_T0.5100.70
147_K209_D0.5080.70
113_K356_L0.5060.70
47_E333_L0.5030.69
180_F238_G0.5030.69
277_F307_F0.5010.69
29_I199_V0.5000.69
341_M358_Y0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4h1bA 1 0.8685 100 0.401 Contact Map
1c0pA 2 0.8219 100 0.439 Contact Map
3axbA 2 0.8712 100 0.44 Contact Map
3pvcA 1 0.8849 100 0.444 Contact Map
1y56B 1 0.8712 100 0.447 Contact Map
2gf3A 1 0.8767 100 0.45 Contact Map
4rslA 1 0.874 100 0.454 Contact Map
1ryiA 4 0.8795 100 0.455 Contact Map
4x9mA 1 0.874 100 0.457 Contact Map
3wgtA 2 0.8521 100 0.46 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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