GREMLIN Database
Q97ZD3 - Glycogen synthase
UniProt: Q97ZD3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 566 (453)
Sequences: 4445 (3088)
Seq/√Len: 145.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
350_L426_S4.0951.00
184_Y237_E3.5331.00
337_D421_L3.4341.00
451_P508_L3.3911.00
428_V453_I3.1481.00
501_S505_K3.1321.00
258_D261_N3.0541.00
335_R379_R2.9451.00
498_S501_S2.9361.00
20_T36_V2.8481.00
16_V48_V2.8001.00
27_A54_L2.6761.00
191_Y356_V2.6601.00
426_S450_L2.6241.00
241_C247_V2.6181.00
19_I140_L2.4421.00
36_V158_Q2.4011.00
501_S504_N2.3921.00
48_V531_I2.3851.00
497_L500_A2.3731.00
394_W398_E2.3661.00
390_Y393_L2.2741.00
246_M272_C2.2621.00
183_I248_S2.2611.00
416_L420_K2.2551.00
286_Q320_T2.2291.00
445_A450_L2.2191.00
390_Y394_W2.1951.00
501_S508_L2.1881.00
21_F161_H2.1831.00
323_N326_W2.1831.00
454_A478_L2.1681.00
258_D265_N2.1521.00
429_F445_A2.1011.00
258_D264_G2.0771.00
505_K509_L2.0551.00
498_S508_L2.0171.00
53_F143_F2.0151.00
51_T150_N2.0101.00
525_K529_N1.9931.00
98_E105_K1.9881.00
15_K49_D1.9811.00
419_Y423_H1.9741.00
349_V428_V1.9571.00
505_K508_L1.9371.00
501_S509_L1.9281.00
488_A492_R1.9271.00
369_K402_E1.9071.00
157_A166_A1.9021.00
504_N508_L1.8971.00
350_L422_F1.8941.00
508_L513_S1.8891.00
343_L346_G1.8851.00
456_S480_K1.8651.00
393_L396_I1.8521.00
246_M536_S1.8411.00
222_Y225_S1.8191.00
374_E492_R1.8171.00
529_N532_T1.8151.00
502_E505_K1.8091.00
431_I441_N1.8031.00
246_M270_K1.7851.00
358_Q435_W1.7611.00
253_S461_R1.7471.00
170_K245_D1.7291.00
509_L513_S1.7261.00
466_D493_I1.6961.00
320_T323_N1.6901.00
156_H185_T1.6821.00
497_L501_S1.6781.00
348_L425_V1.6761.00
258_D266_W1.6651.00
185_T248_S1.6651.00
46_K528_E1.6621.00
505_K513_S1.6561.00
394_W397_I1.6491.00
453_I491_I1.6441.00
51_T107_I1.6361.00
510_Y514_E1.6241.00
393_L397_I1.6201.00
498_S504_N1.6171.00
351_F364_L1.6101.00
218_K222_Y1.6091.00
409_L412_G1.5931.00
258_D262_F1.5921.00
284_E287_N1.5831.00
504_N509_L1.5811.00
503_L507_D1.5761.00
492_R496_Y1.5731.00
267_V270_K1.5601.00
498_S509_L1.5551.00
504_N507_D1.5521.00
508_L514_E1.5431.00
217_A220_E1.5391.00
331_R335_R1.5331.00
220_E224_Y1.5301.00
252_Y275_Y1.5081.00
18_M158_Q1.5061.00
336_D342_D1.5061.00
383_F422_F1.5031.00
155_I165_P1.5011.00
333_G336_D1.5001.00
156_H534_V1.4991.00
454_A464_V1.4951.00
163_V184_Y1.4941.00
451_P504_N1.4881.00
332_L344_G1.4881.00
169_I173_L1.4871.00
23_L54_L1.4871.00
183_I537_R1.4711.00
53_F109_V1.4651.00
498_S502_E1.4631.00
498_S505_K1.4521.00
256_S259_V1.4471.00
333_G337_D1.4351.00
428_V501_S1.4241.00
26_I108_L1.4161.00
262_F266_W1.3981.00
167_V239_F1.3961.00
456_S478_L1.3951.00
509_L514_E1.3821.00
252_Y529_N1.3681.00
393_L399_R1.3631.00
121_D126_Y1.3581.00
400_A404_K1.3531.00
420_K423_H1.3381.00
341_D405_D1.3351.00
181_P537_R1.3321.00
329_R332_L1.3261.00
129_T132_K1.3201.00
142_G173_L1.3161.00
367_A370_T1.3141.00
23_L52_V1.3071.00
349_V378_A1.3011.00
370_T485_D1.3001.00
70_S73_H1.2951.00
490_A493_I1.2891.00
389_D396_I1.2881.00
368_M399_R1.2881.00
392_L396_I1.2871.00
348_L381_L1.2831.00
56_S108_L1.2801.00
484_I488_A1.2781.00
186_I241_C1.2781.00
343_L377_N1.2761.00
396_I399_R1.2751.00
349_V491_I1.2741.00
423_H441_N1.2721.00
483_S486_E1.2711.00
272_C536_S1.2691.00
395_D399_R1.2581.00
259_V262_F1.2581.00
100_K105_K1.2561.00
502_E506_S1.2551.00
121_D125_I1.2551.00
20_T23_L1.2541.00
501_S507_D1.2521.00
326_W330_N1.2511.00
283_E420_K1.2511.00
347_P428_V1.2441.00
369_K373_N1.2291.00
492_R495_L1.2271.00
441_N445_A1.2241.00
217_A222_Y1.2221.00
17_W51_T1.2171.00
260_F264_G1.2171.00
216_V224_Y1.2091.00
69_L98_E1.2081.00
49_D150_N1.2051.00
258_D263_V1.2021.00
19_I165_P1.2011.00
362_D434_R1.1841.00
421_L424_Y1.1831.00
503_L506_S1.1811.00
416_L419_Y1.1791.00
328_N332_L1.1731.00
488_A494_A1.1691.00
44_A105_K1.1681.00
262_F265_N1.1661.00
184_Y240_G1.1651.00
417_D421_L1.1641.00
367_A488_A1.1641.00
259_V264_G1.1611.00
170_K174_E1.1541.00
508_L511_K1.1501.00
346_G379_R1.1470.99
216_V222_Y1.1460.99
24_Q33_G1.1430.99
335_R342_D1.1410.99
320_T324_M1.1370.99
20_T158_Q1.1360.99
260_F265_N1.1350.99
507_D511_K1.1320.99
122_S125_I1.1240.99
194_V226_Y1.1180.99
488_A495_L1.1150.99
192_I235_K1.1130.99
220_E223_K1.1070.99
423_H444_E1.1050.99
486_E489_R1.1020.99
506_S510_Y1.1000.99
326_W329_R1.1000.99
415_D419_Y1.1000.99
247_V270_K1.0990.99
261_N265_N1.0980.99
351_F361_V1.0980.99
441_N444_E1.0980.99
52_V106_V1.0910.99
405_D408_R1.0880.99
367_A371_V1.0830.99
465_V475_T1.0810.99
259_V266_W1.0790.99
215_M220_E1.0780.99
51_T105_K1.0730.99
497_L508_L1.0730.99
35_A40_A1.0700.99
157_A184_Y1.0670.99
129_T133_I1.0640.99
158_Q185_T1.0610.99
327_N450_L1.0610.99
15_K153_D1.0600.99
18_M36_V1.0590.99
504_N514_E1.0580.99
446_M475_T1.0560.99
423_H445_A1.0530.99
332_L336_D1.0520.99
391_N394_W1.0390.99
190_N435_W1.0370.99
481_P486_E1.0320.99
92_Y113_D1.0310.99
46_K531_I1.0290.99
484_I487_L1.0260.99
404_K409_L1.0260.99
248_S533_R1.0200.99
403_I406_N1.0080.99
45_E524_D1.0060.99
408_R411_V1.0020.99
259_V263_V1.0000.99
112_L116_T0.9990.99
504_N511_K0.9930.99
364_L430_V0.9920.99
500_A503_L0.9920.99
329_R333_G0.9910.99
28_S34_N0.9910.99
18_M43_L0.9880.98
320_T326_W0.9870.98
385_L412_G0.9860.98
158_Q248_S0.9860.98
415_D418_L0.9860.98
532_T536_S0.9840.98
392_L399_R0.9830.98
221_L239_F0.9820.98
219_H224_Y0.9800.98
263_V266_W0.9790.98
158_Q162_A0.9770.98
249_S255_L0.9760.98
371_V491_I0.9740.98
501_S514_E0.9740.98
372_V407_I0.9730.98
377_N406_N0.9720.98
215_M224_Y0.9720.98
353_G361_V0.9720.98
42_H45_E0.9680.98
96_F109_V0.9680.98
371_V378_A0.9640.98
259_V265_N0.9610.98
272_C533_R0.9520.98
532_T535_K0.9500.98
418_L421_L0.9470.98
425_V450_L0.9440.98
19_I162_A0.9390.98
169_I172_L0.9370.98
367_A487_L0.9340.98
475_T511_K0.9330.98
365_L395_D0.9300.98
389_D392_L0.9230.98
335_R346_G0.9210.98
335_R340_Y0.9190.98
58_G116_T0.9180.98
121_D124_N0.9170.98
218_K221_L0.9130.97
506_S509_L0.9090.97
215_M222_Y0.9090.97
455_Y479_I0.9080.97
389_D393_L0.9050.97
489_R493_I0.9000.97
80_G90_Y0.8990.97
216_V220_E0.8960.97
285_I288_K0.8940.97
42_H524_D0.8930.97
350_L381_L0.8910.97
446_M464_V0.8890.97
163_V235_K0.8880.97
261_N264_G0.8860.97
380_L407_I0.8850.97
511_K514_E0.8790.97
255_L273_V0.8780.97
61_L64_Y0.8780.97
261_N266_W0.8780.97
157_A165_P0.8750.97
370_T492_R0.8710.97
360_G432_P0.8690.97
504_N513_S0.8690.97
17_W150_N0.8690.97
136_L140_L0.8680.97
528_E532_T0.8670.97
278_T447_A0.8650.96
21_F125_I0.8640.96
391_N395_D0.8640.96
395_D398_E0.8630.96
137_T165_P0.8630.96
281_D284_E0.8620.96
349_V380_L0.8620.96
349_V487_L0.8600.96
420_K424_Y0.8600.96
476_G479_I0.8590.96
418_L423_H0.8570.96
44_A50_I0.8540.96
510_Y513_S0.8520.96
217_A224_Y0.8510.96
419_Y422_F0.8510.96
485_D489_R0.8490.96
170_K173_L0.8480.96
400_A403_I0.8430.96
62_N66_R0.8400.96
507_D514_E0.8400.96
525_K528_E0.8380.96
405_D409_L0.8380.96
41_K102_D0.8370.96
282_V420_K0.8370.96
58_G112_L0.8330.96
100_K103_N0.8330.96
389_D399_R0.8320.96
42_H527_R0.8300.96
51_T152_P0.8300.96
280_W447_A0.8300.96
368_M380_L0.8300.96
49_D105_K0.8290.96
96_F143_F0.8290.96
260_F263_V0.8270.95
456_S461_R0.8260.95
368_M382_I0.8250.95
120_L125_I0.8230.95
169_I174_E0.8200.95
90_Y120_L0.8170.95
493_I496_Y0.8160.95
370_T373_N0.8150.95
382_I396_I0.8150.95
368_M372_V0.8140.95
398_E402_E0.8130.95
507_D513_S0.8130.95
29_V125_I0.8130.95
258_D271_S0.8120.95
114_Y131_E0.8110.95
340_Y379_R0.8100.95
498_S507_D0.8090.95
490_A494_A0.8090.95
169_I182_F0.8070.95
107_I143_F0.8060.95
69_L72_R0.8010.95
220_E243_E0.8000.95
484_I490_A0.7980.95
253_S256_S0.7970.94
181_P245_D0.7970.94
498_S514_E0.7950.94
417_D420_K0.7940.94
338_W408_R0.7920.94
370_T488_A0.7910.94
128_N132_K0.7910.94
123_W126_Y0.7860.94
346_G377_N0.7840.94
260_F266_W0.7820.94
215_M219_H0.7810.94
341_D346_G0.7800.94
327_N331_R0.7790.94
95_G110_K0.7780.94
154_I181_P0.7760.94
138_R142_G0.7740.94
238_K242_Y0.7730.94
199_A234_G0.7720.93
215_M221_L0.7720.93
370_T374_E0.7710.93
505_K514_E0.7700.93
216_V223_K0.7700.93
154_I183_I0.7680.93
195_P236_I0.7680.93
524_D528_E0.7650.93
250_V276_N0.7640.93
396_I400_A0.7630.93
283_E444_E0.7590.93
488_A496_Y0.7580.93
403_I409_L0.7580.93
30_G354_R0.7560.93
31_G359_K0.7550.93
350_L429_F0.7490.92
361_V396_I0.7480.92
275_Y463_T0.7460.92
416_L423_H0.7440.92
380_L384_G0.7380.92
70_S76_M0.7380.92
325_L328_N0.7360.92
334_L338_W0.7350.92
21_F57_H0.7340.92
393_L403_I0.7340.92
287_N290_V0.7340.92
168_R172_L0.7300.91
507_D510_Y0.7270.91
354_R359_K0.7260.91
31_G354_R0.7260.91
122_S126_Y0.7230.91
357_Y391_N0.7220.91
56_S97_E0.7220.91
17_W53_F0.7200.91
523_W526_V0.7200.91
284_E447_A0.7190.91
157_A162_A0.7190.91
488_A491_I0.7180.91
429_F441_N0.7170.91
80_G92_Y0.7170.91
40_A106_V0.7170.91
337_D417_D0.7150.91
465_V474_A0.7120.90
67_S71_L0.7120.90
216_V225_S0.7090.90
58_G123_W0.7070.90
23_L36_V0.7070.90
272_C275_Y0.7070.90
221_L224_Y0.7060.90
217_A221_L0.7010.90
336_D339_T0.7000.90
67_S70_S0.7000.90
218_K224_Y0.6980.90
94_I135_L0.6980.90
490_A496_Y0.6970.89
184_Y241_C0.6970.89
484_I492_R0.6970.89
531_I535_K0.6960.89
497_L504_N0.6930.89
157_A182_F0.6900.89
70_S97_E0.6900.89
57_H133_I0.6900.89
37_Y40_A0.6880.89
501_S506_S0.6870.89
19_I53_F0.6860.89
408_R412_G0.6860.89
399_R403_I0.6860.89
14_K48_V0.6850.89
218_K223_K0.6840.89
144_T150_N0.6830.89
338_W381_L0.6820.88
392_L395_D0.6790.88
53_F140_L0.6780.88
271_S275_Y0.6760.88
94_I97_E0.6740.88
223_K226_Y0.6740.88
334_L425_V0.6730.88
416_L421_L0.6710.88
533_R537_R0.6710.88
256_S260_F0.6690.88
428_V494_A0.6680.87
487_L491_I0.6670.87
189_L435_W0.6670.87
166_A244_A0.6660.87
333_G421_L0.6650.87
137_T140_L0.6650.87
279_D282_V0.6650.87
341_D406_N0.6630.87
68_L71_L0.6620.87
282_V416_L0.6600.87
327_N330_N0.6560.86
332_L343_L0.6560.86
497_L505_K0.6520.86
163_V239_F0.6510.86
15_K151_L0.6490.86
442_S463_T0.6480.86
436_E439_G0.6470.86
195_P200_S0.6460.86
111_G135_L0.6450.86
464_V476_G0.6440.85
122_S128_N0.6420.85
505_K511_K0.6400.85
215_M223_K0.6380.85
366_R484_I0.6370.85
215_M218_K0.6370.85
477_L490_A0.6350.85
46_K527_R0.6350.85
362_D398_E0.6330.84
119_V126_Y0.6320.84
347_P350_L0.6320.84
166_A243_E0.6300.84
111_G114_Y0.6290.84
24_Q37_Y0.6290.84
134_S204_S0.6280.84
418_L422_F0.6280.84
250_V254_Y0.6280.84
275_Y443_I0.6280.84
166_A182_F0.6270.84
74_I78_V0.6260.84
31_G250_V0.6260.84
35_A526_V0.6250.84
324_M327_N0.6230.84
197_H208_D0.6230.84
18_M40_A0.6220.83
396_I403_I0.6210.83
502_E508_L0.6190.83
347_P495_L0.6190.83
129_T444_E0.6180.83
219_H238_K0.6170.83
43_L50_I0.6170.83
64_Y108_L0.6170.83
438_F442_S0.6160.83
194_V235_K0.6140.83
125_I129_T0.6130.83
30_G359_K0.6120.82
348_L422_F0.6120.82
217_A223_K0.6110.82
267_V271_S0.6100.82
484_I494_A0.6090.82
400_A408_R0.6090.82
189_L258_D0.6080.82
136_L139_G0.6080.82
171_Q174_E0.6060.82
391_N396_I0.6060.82
499_E506_S0.6060.82
349_V364_L0.6060.82
250_V358_Q0.6060.82
28_S358_Q0.6060.82
366_R369_K0.6050.82
323_N327_N0.6050.82
246_M537_R0.6050.82
400_A409_L0.6040.82
274_T533_R0.6040.82
71_L74_I0.6030.82
428_V451_P0.6030.82
398_E401_S0.6030.82
374_E377_N0.6020.81
372_V406_N0.6000.81
164_I168_R0.6000.81
374_E495_L0.5990.81
422_F426_S0.5980.81
149_S152_P0.5980.81
272_C529_N0.5980.81
332_L342_D0.5970.81
343_L379_R0.5970.81
67_S73_H0.5940.81
23_L106_V0.5930.80
497_L509_L0.5930.80
501_S513_S0.5930.80
470_D473_N0.5920.80
90_Y113_D0.5910.80
487_L490_A0.5890.80
156_H248_S0.5890.80
97_E100_K0.5890.80
109_V136_L0.5880.80
402_E405_D0.5880.80
466_D471_K0.5880.80
439_G458_G0.5870.80
253_S457_V0.5870.80
348_L379_R0.5840.79
385_L413_R0.5840.79
92_Y96_F0.5820.79
259_V271_S0.5820.79
250_V354_R0.5800.79
278_T444_E0.5780.79
284_E288_K0.5770.79
331_R348_L0.5770.79
416_L424_Y0.5770.79
17_W144_T0.5760.79
349_V494_A0.5750.78
279_D285_I0.5740.78
443_I521_R0.5730.78
60_H108_L0.5730.78
16_V50_I0.5720.78
90_Y93_K0.5710.78
14_K153_D0.5700.78
247_V267_V0.5690.78
15_K150_N0.5690.78
431_I445_A0.5690.78
420_K444_E0.5680.78
369_K372_V0.5680.78
155_I180_V0.5670.77
45_E281_D0.5670.77
93_K110_K0.5660.77
146_G151_L0.5660.77
159_D358_Q0.5650.77
72_R76_M0.5630.77
42_H523_W0.5630.77
184_Y191_Y0.5630.77
475_T521_R0.5630.77
350_L450_L0.5620.77
56_S61_L0.5620.77
351_F396_I0.5620.77
140_L165_P0.5610.77
78_V138_R0.5610.77
342_D346_G0.5580.76
321_T324_M0.5550.76
75_D78_V0.5550.76
70_S74_I0.5550.76
109_V139_G0.5540.76
23_L158_Q0.5530.76
485_D492_R0.5530.76
279_D283_E0.5520.76
423_H429_F0.5520.76
280_W522_Y0.5520.76
349_V430_V0.5500.75
136_L162_A0.5480.75
498_S513_S0.5470.75
428_V505_K0.5470.75
419_Y424_Y0.5460.75
465_V473_N0.5440.75
461_R478_L0.5440.75
404_K408_R0.5430.74
56_S110_K0.5430.74
323_N330_N0.5430.74
135_L139_G0.5420.74
497_L503_L0.5410.74
219_H222_Y0.5410.74
466_D470_D0.5400.74
275_Y278_T0.5370.74
159_D188_L0.5370.74
335_R343_L0.5350.73
134_S138_R0.5340.73
389_D395_D0.5340.73
219_H225_S0.5330.73
44_A52_V0.5330.73
277_G285_I0.5320.73
188_L358_Q0.5310.73
380_L430_V0.5310.73
41_K281_D0.5300.73
40_A52_V0.5300.73
466_D475_T0.5300.73
358_Q437_P0.5290.72
406_N409_L0.5290.72
39_I50_I0.5290.72
157_A199_A0.5270.72
453_I494_A0.5270.72
252_Y273_V0.5250.72
367_A374_E0.5250.72
218_K225_S0.5250.72
454_A460_L0.5240.72
164_I236_I0.5240.72
443_I446_M0.5230.72
324_M505_K0.5220.71
498_S503_L0.5220.71
141_E172_L0.5210.71
35_A38_N0.5190.71
73_H76_M0.5190.71
96_F99_G0.5190.71
251_S439_G0.5190.71
189_L265_N0.5190.71
501_S511_K0.5190.71
499_E504_N0.5190.71
157_A241_C0.5180.71
320_T329_R0.5160.71
108_L235_K0.5160.71
71_L76_M0.5160.71
410_I418_L0.5150.70
92_Y95_G0.5150.70
353_G441_N0.5130.70
324_M328_N0.5120.70
129_T136_L0.5110.70
253_S456_S0.5110.70
225_S232_S0.5110.70
76_M80_G0.5110.70
486_E493_I0.5090.70
360_G442_S0.5080.69
251_S254_Y0.5080.69
360_G433_S0.5070.69
522_Y525_K0.5070.69
21_F29_V0.5060.69
434_R482_E0.5050.69
486_E490_A0.5040.69
356_V435_W0.5020.69
248_S537_R0.5020.69
244_A247_V0.5020.69
500_A508_L0.5010.68
497_L514_E0.5010.68
431_I442_S0.5010.68
451_P511_K0.5000.68
402_E406_N0.5000.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3vueA 1 0.8039 100 0.432 Contact Map
4l22A 1 0.9576 100 0.443 Contact Map
4qlbA 3 0.8551 100 0.446 Contact Map
2c4mA 4 0.9276 100 0.458 Contact Map
1rzuA 1 0.7951 100 0.47 Contact Map
3nb0A 4 0.8657 100 0.473 Contact Map
2qzsA 1 0.8057 100 0.48 Contact Map
2gj4A 2 0.9134 100 0.483 Contact Map
1l5wA 2 0.9488 100 0.489 Contact Map
4bqeA 2 0.924 100 0.509 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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