GREMLIN Database
Q97ZD1 - Sugar phosphate nucleotydyl transferase
UniProt: Q97ZD1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 422 (332)
Sequences: 7432 (4763)
Seq/√Len: 261.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
327_I330_S3.9931.00
361_I364_S3.7551.00
154_K189_D3.2891.00
344_I347_S3.2861.00
141_H149_T3.1761.00
345_V362_E3.1251.00
329_E346_R2.8891.00
349_I355_I2.7551.00
328_E345_V2.7541.00
168_T172_A2.7241.00
356_G374_S2.7051.00
154_K241_P2.6421.00
339_G357_D2.5491.00
335_F352_R2.4781.00
139_E143_S2.4591.00
318_H335_F2.4451.00
346_R363_N2.4311.00
330_S344_I2.3321.00
40_R48_L2.3251.00
340_K357_D2.3121.00
12_V55_I2.3021.00
357_D374_S2.2911.00
299_Q302_F2.2671.00
147_L199_S2.2211.00
137_A151_V2.1961.00
310_E328_E2.1961.00
12_V50_L2.1931.00
334_N351_D2.1301.00
152_L239_G2.0851.00
140_F144_K2.0831.00
316_G334_N2.0691.00
326_Y343_K2.0601.00
317_R334_N2.0521.00
166_D188_S2.0441.00
166_D175_K2.0421.00
173_I239_G2.0401.00
320_Q337_M2.0161.00
366_I372_I2.0161.00
309_I313_A2.0141.00
312_D329_E2.0071.00
332_I338_I1.9871.00
205_I209_N1.9861.00
146_S238_Y1.9511.00
168_T174_R1.9111.00
47_I58_F1.8751.00
349_I353_G1.8621.00
341_G358_N1.8521.00
137_A197_I1.8311.00
332_I336_T1.8291.00
44_E74_L1.8151.00
121_I200_P1.8121.00
342_V359_V1.7981.00
333_D351_D1.7811.00
323_D340_K1.7671.00
138_L197_I1.7641.00
172_A236_P1.7391.00
172_A238_Y1.7011.00
322_G340_K1.6871.00
50_L124_V1.6531.00
140_F240_Y1.6491.00
30_T36_R1.6351.00
43_I75_F1.6141.00
337_M354_Y1.6051.00
144_K238_Y1.6011.00
322_G339_G1.5991.00
366_I370_V1.5851.00
205_I233_K1.5801.00
102_I106_D1.5761.00
308_K326_Y1.5711.00
204_K207_K1.5671.00
343_K360_H1.5611.00
336_T353_G1.5431.00
319_C336_T1.5421.00
319_C332_I1.5311.00
135_T139_E1.5201.00
299_Q317_R1.5061.00
120_P199_S1.4971.00
298_I302_F1.4841.00
353_G370_V1.4811.00
203_R207_K1.4621.00
117_I120_P1.4381.00
339_G356_G1.4311.00
200_P204_K1.4311.00
339_G354_Y1.4251.00
137_A149_T1.4191.00
354_Y371_E1.4191.00
123_V198_L1.4181.00
147_L236_P1.4101.00
147_L235_Y1.4011.00
122_V197_I1.3951.00
91_V95_Y1.3901.00
68_Y72_F1.3791.00
202_I206_F1.3791.00
152_L165_A1.3761.00
209_N233_K1.3751.00
229_Y233_K1.3651.00
120_P142_E1.3631.00
44_E48_L1.3491.00
315_I319_C1.3471.00
130_F133_D1.3261.00
300_R317_R1.3241.00
245_I261_T1.3231.00
249_I258_A1.3161.00
112_I204_K1.3111.00
42_L249_I1.3081.00
166_D177_V1.3031.00
59_I96_Q1.2881.00
359_V374_S1.2561.00
148_M230_L1.2471.00
347_S361_I1.2461.00
173_I237_V1.2361.00
116_D204_K1.2351.00
62_V68_Y1.2211.00
247_F261_T1.2171.00
167_T239_G1.2061.00
140_F238_Y1.1861.00
302_F319_C1.1851.00
106_D110_I1.1801.00
11_K57_E1.1751.00
318_H334_N1.1691.00
325_T342_V1.1641.00
43_I71_L1.1631.00
230_L235_Y1.1571.00
34_A74_L1.1511.00
136_K139_E1.1501.00
38_L262_L1.1381.00
297_E314_L1.1241.00
344_I349_I1.1201.00
133_D136_K1.1101.00
57_E92_H1.1011.00
30_T70_S1.0991.00
109_R112_I1.0981.00
306_L323_D1.0971.00
304_K323_D1.0961.00
331_N348_A1.0961.00
253_E257_D1.0951.00
106_D109_R1.0841.00
303_K309_I1.0821.00
163_G178_E1.0771.00
314_L331_N1.0761.00
321_I325_T1.0741.00
303_K307_I1.0711.00
202_I235_Y1.0681.00
327_I332_I1.0661.00
11_K115_Y1.0591.00
345_V360_H1.0521.00
295_R312_D1.0491.00
219_K225_D1.0481.00
70_S73_D1.0451.00
58_F91_V1.0451.00
29_E318_H1.0441.00
167_T190_L1.0441.00
192_N196_Y1.0421.00
164_V191_I1.0391.00
59_I114_Y1.0361.00
304_K307_I1.0341.00
202_I205_I1.0231.00
152_L190_L1.0211.00
231_I237_V1.0211.00
108_V123_V1.0211.00
198_L226_I1.0211.00
206_F233_K1.0201.00
91_V94_K1.0191.00
37_L259_M1.0151.00
140_F143_S1.0101.00
20_A32_K1.0011.00
44_E78_G0.9981.00
150_I173_I0.9951.00
33_A126_G0.9911.00
339_G342_V0.9881.00
302_F334_N0.9801.00
358_N374_S0.9741.00
112_I208_S0.9691.00
358_N375_N0.9671.00
148_M198_L0.9661.00
333_D336_T0.9631.00
43_I60_F0.9631.00
31_S70_S0.9631.00
158_D161_E0.9601.00
124_V134_I0.9571.00
131_K245_I0.9561.00
352_R369_H0.9551.00
177_V187_P0.9531.00
336_T349_I0.9521.00
76_K95_Y0.9511.00
125_Q128_N0.9491.00
344_I361_I0.9491.00
207_K210_D0.9471.00
165_A173_I0.9441.00
177_V182_R0.9431.00
68_Y97_P0.9401.00
41_P44_E0.9391.00
228_P232_N0.9341.00
306_L322_G0.9331.00
343_K358_N0.9281.00
44_E75_F0.9261.00
356_G371_E0.9261.00
353_G366_I0.9211.00
247_F257_D0.9201.00
215_Y225_D0.9191.00
69_R73_D0.9171.00
336_T351_D0.9171.00
102_I220_M0.9161.00
37_L42_L0.9111.00
322_G337_M0.9021.00
45_Y262_L0.8981.00
72_F97_P0.8971.00
136_K140_F0.8971.00
22_R32_K0.8941.00
36_R41_P0.8931.00
112_I207_K0.8911.00
119_E200_P0.8891.00
304_K322_G0.8881.00
251_T254_R0.8851.00
310_E326_Y0.8851.00
202_I207_K0.8791.00
60_F75_F0.8721.00
32_K127_D0.8701.00
39_N314_L0.8691.00
313_A327_I0.8681.00
336_T355_I0.8661.00
341_G357_D0.8611.00
342_V374_S0.8591.00
14_I47_I0.8521.00
13_I59_I0.8521.00
304_K320_Q0.8500.99
209_N229_Y0.8460.99
336_T350_M0.8460.99
342_V356_G0.8460.99
371_E374_S0.8450.99
48_L52_K0.8440.99
260_V263_L0.8430.99
13_I121_I0.8420.99
171_L241_P0.8410.99
101_S106_D0.8380.99
150_I165_A0.8370.99
145_S199_S0.8360.99
92_H95_Y0.8360.99
41_P74_L0.8330.99
190_L239_G0.8290.99
34_A70_S0.8280.99
201_E205_I0.8280.99
316_G319_C0.8270.99
53_Q134_I0.8270.99
359_V372_I0.8240.99
342_V358_N0.8230.99
155_Y191_I0.8210.99
122_V138_L0.8180.99
298_I315_I0.8180.99
319_C333_D0.8140.99
355_I361_I0.8110.99
147_L202_I0.8110.99
148_M227_I0.8080.99
304_K308_K0.8080.99
215_Y218_G0.8070.99
255_Y350_M0.8060.99
338_I342_V0.8050.99
30_T367_A0.8020.99
106_D220_M0.8020.99
356_G373_R0.8010.99
266_L270_E0.8010.99
69_R72_F0.7980.99
296_R309_I0.7960.99
210_D218_G0.7960.99
46_T124_V0.7950.99
361_I366_I0.7950.99
186_A189_D0.7940.99
206_F230_L0.7900.99
342_V357_D0.7880.99
18_G32_K0.7860.99
122_V134_I0.7850.99
350_M365_I0.7840.99
45_Y48_L0.7810.99
136_K243_K0.7780.99
357_D375_N0.7760.99
41_P45_Y0.7720.99
278_P281_R0.7700.99
204_K208_S0.7690.99
348_A365_I0.7620.99
206_F209_N0.7600.99
166_D174_R0.7600.99
148_M237_V0.7590.99
55_I138_L0.7580.99
163_G179_K0.7570.99
229_Y232_N0.7550.99
190_L241_P0.7510.99
264_H268_D0.7500.99
342_V355_I0.7500.99
92_H96_Q0.7480.99
247_F258_A0.7480.99
112_I116_D0.7440.99
59_I115_Y0.7410.99
267_S271_I0.7380.99
31_S67_N0.7340.99
315_I321_I0.7340.99
295_R298_I0.7300.98
127_D248_D0.7270.98
203_R206_F0.7270.98
220_M225_D0.7260.98
219_K224_K0.7240.98
221_D224_K0.7210.98
50_L55_I0.7170.98
153_K191_I0.7160.98
49_E134_I0.7100.98
256_L279_N0.7090.98
49_E53_Q0.7040.98
267_S276_I0.7040.98
153_K246_W0.7040.98
139_E142_E0.6990.98
319_C334_N0.6980.98
51_A91_V0.6960.98
138_L142_E0.6950.98
95_Y98_R0.6950.98
61_G107_S0.6920.98
306_L310_E0.6910.98
27_T35_V0.6910.98
13_I108_V0.6860.98
59_I111_N0.6850.98
51_A78_G0.6830.98
203_R209_N0.6820.98
14_I50_L0.6800.98
116_D208_S0.6780.98
146_S236_P0.6780.98
353_G367_A0.6760.97
199_S202_I0.6710.97
198_L202_I0.6700.97
18_G22_R0.6700.97
76_K80_G0.6690.97
22_R33_A0.6630.97
182_R187_P0.6630.97
299_Q334_N0.6610.97
57_E94_K0.6600.97
129_I133_D0.6600.97
62_V95_Y0.6580.97
23_L35_V0.6580.97
10_V138_L0.6570.97
51_A58_F0.6570.97
325_T340_K0.6570.97
296_R299_Q0.6550.97
367_A370_V0.6490.97
20_A33_A0.6480.97
156_E189_D0.6470.97
11_K59_I0.6470.97
266_L269_S0.6460.97
67_N70_S0.6450.97
150_I237_V0.6440.97
151_V195_I0.6420.97
141_H199_S0.6420.97
104_N127_D0.6410.97
310_E313_A0.6380.96
15_P107_S0.6330.96
343_K357_D0.6290.96
333_D348_A0.6290.96
343_K362_E0.6290.96
92_H97_P0.6280.96
47_I75_F0.6240.96
165_A190_L0.6240.96
305_G308_K0.6210.96
215_Y229_Y0.6200.96
93_F96_Q0.6170.96
42_L46_T0.6170.96
149_T197_I0.6160.96
91_V97_P0.6140.96
222_F226_I0.6140.96
14_I46_T0.6130.96
182_R186_A0.6120.96
38_L45_Y0.6120.96
49_E132_L0.6110.95
112_I203_R0.6100.95
47_I93_F0.6090.95
80_G93_F0.6070.95
155_Y158_D0.6060.95
124_V195_I0.6030.95
338_I344_I0.6030.95
298_I301_K0.6010.95
198_L222_F0.6010.95
161_E254_R0.5980.95
130_F195_I0.5970.95
305_G323_D0.5970.95
36_R333_D0.5950.95
332_I349_I0.5930.95
346_R362_E0.5930.95
307_I310_E0.5930.95
155_Y189_D0.5880.94
297_E300_R0.5880.94
202_I230_L0.5860.94
93_F98_R0.5850.94
201_E204_K0.5840.94
109_R207_K0.5840.94
11_K118_N0.5820.94
17_G61_G0.5820.94
54_G135_T0.5810.94
62_V72_F0.5810.94
327_I338_I0.5790.94
75_F78_G0.5780.94
145_S236_P0.5780.94
356_G359_V0.5770.94
205_I208_S0.5760.94
307_I323_D0.5750.94
71_L95_Y0.5750.94
20_A248_D0.5720.94
51_A79_I0.5700.93
267_S270_E0.5680.93
98_R106_D0.5680.93
120_P197_I0.5650.93
332_I344_I0.5640.93
313_A330_S0.5620.93
152_L241_P0.5620.93
321_I332_I0.5610.93
259_M331_N0.5610.93
297_E301_K0.5610.93
360_H363_N0.5580.93
307_I321_I0.5580.93
136_K240_Y0.5570.93
335_F351_D0.5570.93
75_F93_F0.5560.93
150_I196_Y0.5560.93
319_C335_F0.5550.93
26_L255_Y0.5540.93
16_I60_F0.5530.92
351_D368_R0.5520.92
325_T338_I0.5520.92
353_G368_R0.5520.92
117_I204_K0.5510.92
153_K193_T0.5500.92
312_D328_E0.5470.92
206_F210_D0.5460.92
261_T265_T0.5450.92
204_K209_N0.5450.92
133_D245_I0.5450.92
326_Y345_V0.5450.92
11_K117_I0.5440.92
20_A127_D0.5440.92
252_P256_L0.5430.92
73_D76_K0.5430.92
276_I282_I0.5430.92
359_V373_R0.5400.92
18_G104_N0.5400.92
210_D220_M0.5400.92
16_I71_L0.5390.91
325_T328_E0.5390.91
108_V222_F0.5390.91
312_D330_S0.5380.91
295_R299_Q0.5370.91
119_E199_S0.5360.91
163_G176_F0.5360.91
76_K79_I0.5350.91
264_H267_S0.5340.91
333_D350_M0.5330.91
339_G343_K0.5330.91
276_I284_V0.5330.91
125_Q196_Y0.5320.91
178_E192_N0.5320.91
149_T240_Y0.5310.91
261_T264_H0.5280.91
48_L78_G0.5270.91
255_Y259_M0.5240.90
307_I319_C0.5220.90
315_I327_I0.5220.90
152_L173_I0.5220.90
262_L271_I0.5220.90
151_V193_T0.5210.90
179_K250_G0.5210.90
33_A71_L0.5210.90
307_I327_I0.5200.90
18_G103_G0.5190.90
24_R28_I0.5190.90
34_A43_I0.5190.90
202_I210_D0.5170.90
180_P217_M0.5160.90
349_I366_I0.5150.90
146_S149_T0.5150.90
205_I229_Y0.5150.90
62_V71_L0.5150.90
39_N316_G0.5130.89
61_G98_R0.5130.89
155_Y159_L0.5120.89
11_K121_I0.5110.89
154_K190_L0.5110.89
302_F315_I0.5110.89
70_S74_L0.5100.89
226_I229_Y0.5100.89
159_L186_A0.5100.89
357_D360_H0.5090.89
142_E197_I0.5070.89
164_V180_P0.5060.89
53_Q135_T0.5060.89
306_L340_K0.5040.89
174_R177_V0.5040.89
145_S201_E0.5040.89
198_L203_R0.5040.89
21_T24_R0.5030.88
312_D331_N0.5030.88
304_K325_T0.5020.88
104_N108_V0.5010.88
277_D280_R0.5000.88
35_V252_P0.5000.88
319_C351_D0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3brkX 2 0.8768 100 0.404 Contact Map
1yp2A 4 0.9005 100 0.405 Contact Map
2ggoA 3 0.872 100 0.406 Contact Map
4g3qA 3 0.9147 100 0.427 Contact Map
1hm9A 3 0.91 100 0.43 Contact Map
2v0hA 3 0.9076 100 0.445 Contact Map
4fceA 3 0.8957 100 0.454 Contact Map
2icyA 1 0.7844 100 0.567 Contact Map
2i5kA 5 0.763 100 0.581 Contact Map
1iimA 3 0.6777 100 0.6 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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