GREMLIN Database
Q97ZC7 - Uncharacterized protein
UniProt: Q97ZC7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 123 (115)
Sequences: 495 (414)
Seq/√Len: 38.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_G13_E4.0431.00
47_E68_R2.9001.00
16_K32_I2.7541.00
49_T68_R2.6511.00
81_W90_G2.6371.00
32_I50_I2.5451.00
73_E101_Y2.5231.00
6_E86_V2.5211.00
19_I32_I2.3621.00
7_C14_C2.2290.99
9_L17_T2.2290.99
44_L61_T2.2240.99
33_I53_Y2.1810.99
66_H106_K2.1660.99
15_V80_V2.1560.99
83_E88_K1.9120.98
77_R92_R1.9090.98
92_R100_E1.8600.98
92_R96_E1.6250.95
67_N101_Y1.6080.95
69_H101_Y1.5900.95
55_G60_G1.5620.94
96_E100_E1.5620.94
12_N50_I1.5470.94
19_I23_K1.5150.93
37_E41_K1.4980.93
59_V111_K1.4870.93
5_K117_E1.4670.92
18_L119_L1.4230.91
46_L68_R1.4090.90
22_I108_L1.3820.89
29_V52_I1.3780.89
15_V32_I1.3530.88
34_D37_E1.3530.88
22_I27_A1.3360.88
60_G64_M1.3360.88
46_L65_L1.3140.87
73_E100_E1.2270.83
44_L65_L1.2250.83
63_L70_V1.2250.83
49_T71_A1.2160.82
63_L74_L1.1970.81
96_E101_Y1.1970.81
12_N90_G1.1960.81
27_A59_V1.1530.79
93_K113_D1.1460.78
48_P82_S1.1270.77
76_L112_M1.1160.77
9_L14_C1.1090.76
92_R101_Y1.1070.76
72_Y77_R1.1000.75
71_A79_L1.0790.74
11_F50_I1.0560.72
39_A46_L1.0430.71
18_L78_F1.0040.69
61_T65_L1.0020.68
35_H38_N1.0010.68
82_S85_N0.9890.67
5_K91_Y0.9860.67
111_K114_K0.9860.67
13_E17_T0.9750.66
73_E92_R0.9460.64
77_R100_E0.9440.64
25_S118_G0.9340.63
11_F87_V0.9240.62
47_E81_W0.8980.60
24_S40_R0.8870.59
114_K118_G0.8790.58
15_V50_I0.8780.58
10_G80_V0.8710.57
54_F94_P0.8570.56
62_L76_L0.8560.56
35_H51_V0.8540.56
16_K20_E0.8530.56
59_V71_A0.8520.56
12_N16_K0.8310.54
35_H74_L0.8280.54
51_V71_A0.8180.53
70_V94_P0.8170.53
11_F48_P0.8160.53
59_V62_L0.8120.52
59_V72_Y0.8060.52
20_E45_S0.8000.51
9_L102_D0.7980.51
22_I29_V0.7950.51
40_R45_S0.7940.51
20_E23_K0.7940.51
57_P60_G0.7830.50
46_L71_A0.7750.49
94_P112_M0.7730.49
61_T74_L0.7650.48
6_E88_K0.7520.47
55_G64_M0.7450.46
14_C87_V0.7400.46
107_E110_D0.7390.46
30_F34_D0.7380.46
7_C17_T0.7320.45
73_E96_E0.7210.44
47_E71_A0.7190.44
102_D114_K0.7190.44
46_L49_T0.7100.43
82_S87_V0.7100.43
99_E102_D0.6970.42
51_V79_L0.6890.41
18_L48_P0.6860.41
79_L100_E0.6850.41
27_A112_M0.6830.41
39_A74_L0.6820.41
76_L80_V0.6780.40
61_T64_M0.6700.40
71_A96_E0.6660.39
15_V112_M0.6660.39
43_G81_W0.6580.39
52_I80_V0.6580.39
56_N60_G0.6560.38
20_E24_S0.6510.38
11_F17_T0.6430.37
34_D108_L0.6320.36
78_F91_Y0.6270.36
11_F88_K0.6140.35
17_T40_R0.6140.35
40_R84_N0.6120.35
59_V112_M0.6110.35
49_T79_L0.6090.34
40_R87_V0.6040.34
98_G101_Y0.6040.34
20_E43_G0.6020.34
63_L108_L0.6020.34
55_G61_T0.6000.34
37_E99_E0.5990.34
15_V19_I0.5990.34
82_S89_I0.5910.33
13_E16_K0.5900.33
30_F51_V0.5800.32
15_V26_G0.5780.32
44_L64_M0.5750.32
57_P111_K0.5740.32
11_F80_V0.5720.31
8_K12_N0.5630.31
52_I103_I0.5600.31
31_A34_D0.5600.31
18_L22_I0.5590.30
9_L13_E0.5530.30
37_E40_R0.5510.30
31_A61_T0.5510.30
24_S48_P0.5470.30
41_K97_V0.5470.30
86_V94_P0.5470.30
31_A74_L0.5460.29
67_N100_E0.5440.29
89_I92_R0.5430.29
38_N76_L0.5360.29
56_N75_P0.5340.29
9_L81_W0.5330.29
30_F60_G0.5310.28
10_G90_G0.5310.28
21_R25_S0.5300.28
49_T105_N0.5280.28
9_L78_F0.5270.28
30_F55_G0.5240.28
78_F118_G0.5240.28
50_I88_K0.5230.28
32_I52_I0.5160.27
43_G95_S0.5130.27
78_F98_G0.5120.27
16_K24_S0.5110.27
97_V101_Y0.5090.27
44_L51_V0.5050.27
12_N40_R0.5050.27
31_A43_G0.5030.26
40_R96_E0.5020.26
15_V52_I0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1j3mA 2 0.9919 99.9 0.435 Contact Map
1q9uA 2 0.9919 99.9 0.449 Contact Map
1vl6A 4 0.9187 69.2 0.91 Contact Map
2hxsA 1 0.6585 56.1 0.917 Contact Map
2nvuB 1 0.9675 37.8 0.926 Contact Map
1z0jA 1 0.6585 31.9 0.929 Contact Map
2blnA 1 0.5366 27.8 0.931 Contact Map
1u8zA 1 0.6179 21.2 0.934 Contact Map
1pujA 1 0.8455 20.2 0.935 Contact Map
4m8nE 1 0.6341 20.1 0.935 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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