Q97ZC6 - SULSO - GREMLIN Contacts

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Q97ZC6 - Nicotinate-nucleotide pyrophosphorylase [carboxylating]

UniProt:	Q97ZC6	Sequences: MIDWIYVKRLLDYLEEDVMPEDITTKFLEGIRARGIVRCKDSGILAGNRFIVPFLKYLGFSNINGEKDGREVKKGDIVLNFEGDADILTVERLILNFLGKLSGIATITNLMVKKAKEVNPYVRIAGTRKTTPGFRLFEKYAIEVGGGDPHRYNLSDAVLIKDNHITLYGNLEELIKRVKFSVSFTKIIEVEVSSYEDAIRAFKAGADVILLDNMKPYEILPIVNELKSKVLLEASGGITPDNVIDYAKTGVDVISSGYITHSYRSLDFSLDVEKI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	275 (263)
Sequences:	3956 (2495)
Seq/√Len:	153.8

ECOLI - NADC
BACSU - NADC
HALSA - Q9HNY9
SULSO - Q97ZC6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
109_N	113_K	3.954	1.00
215_K	218_E	3.128	1.00
244_I	248_K	3.079	1.00
43_G	266_L	2.984	1.00
131_T	138_E	2.961	1.00
11_L	57_Y	2.666	1.00
192_V	198_A	2.644	1.00
33_A	85_A	2.637	1.00
7_V	53_P	2.604	1.00
199_I	225_E	2.568	1.00
108_T	147_G	2.485	1.00
238_I	246_Y	2.454	1.00
34_R	82_E	2.281	1.00
65_G	80_N	2.254	1.00
67_K	70_R	2.240	1.00
66_E	76_D	2.225	1.00
226_L	232_L	2.217	1.00
45_L	66_E	2.152	1.00
172_E	200_R	2.144	1.00
193_S	197_D	2.061	1.00
87_I	270_L	2.034	1.00
46_A	144_V	2.003	1.00
42_S	73_K	1.963	1.00
78_V	268_F	1.950	1.00
55_L	94_I	1.911	1.00
199_I	203_K	1.899	1.00
58_L	90_V	1.895	1.00
8_K	12_D	1.882	1.00
63_I	80_N	1.849	1.00
59_G	86_D	1.828	1.00
172_E	176_K	1.792	1.00
142_I	147_G	1.784	1.00
115_A	124_I	1.774	1.00
218_E	221_P	1.773	1.00
125_A	253_V	1.754	1.00
113_K	116_K	1.748	1.00
45_L	72_V	1.737	1.00
140_Y	144_V	1.721	1.00
34_R	80_N	1.698	1.00
19_M	155_S	1.691	1.00
219_I	234_A	1.687	1.00
173_E	176_K	1.684	1.00
175_I	190_V	1.637	1.00
100_K	131_T	1.634	1.00
111_M	240_P	1.632	1.00
245_D	248_K	1.628	1.00
170_N	173_E	1.619	1.00
117_E	244_I	1.610	1.00
9_R	12_D	1.588	1.00
42_S	74_K	1.586	1.00
110_L	240_P	1.576	1.00
221_P	224_N	1.575	1.00
114_K	240_P	1.550	1.00
124_I	243_V	1.547	1.00
107_I	263_Y	1.528	1.00
231_L	253_V	1.524	1.00
13_Y	97_F	1.518	1.00
45_L	48_N	1.514	1.00
37_V	268_F	1.513	1.00
18_V	89_T	1.511	1.00
32_R	82_E	1.507	1.00
115_A	122_V	1.503	1.00
118_V	121_Y	1.495	1.00
123_R	148_D	1.470	1.00
24_T	160_I	1.464	1.00
111_M	243_V	1.455	1.00
53_P	56_K	1.451	1.00
219_I	246_Y	1.445	1.00
173_E	177_R	1.440	1.00
198_A	226_L	1.433	1.00
111_M	256_S	1.432	1.00
71_E	109_N	1.430	1.00
99_G	265_S	1.429	1.00
100_K	138_E	1.423	1.00
71_E	113_K	1.409	1.00
30_G	84_D	1.386	1.00
53_P	57_Y	1.379	1.00
73_K	76_D	1.370	1.00
49_R	68_D	1.369	1.00
52_V	56_K	1.358	1.00
117_E	248_K	1.354	1.00
20_P	155_S	1.339	1.00
23_I	186_K	1.334	1.00
45_L	78_V	1.323	1.00
66_E	70_R	1.312	1.00
158_V	182_V	1.291	1.00
162_D	271_D	1.286	1.00
107_I	240_P	1.279	1.00
187_I	207_D	1.273	1.00
7_V	57_Y	1.268	1.00
51_I	79_L	1.252	1.00
40_K	269_S	1.251	1.00
114_K	244_I	1.249	1.00
77_I	80_N	1.249	1.00
8_K	15_E	1.246	1.00
36_I	77_I	1.238	1.00
172_E	203_K	1.236	1.00
35_G	270_L	1.233	1.00
41_D	264_R	1.226	1.00
196_E	199_I	1.225	1.00
8_K	11_L	1.217	1.00
37_V	51_I	1.192	1.00
63_I	82_E	1.189	1.00
46_A	105_A	1.187	1.00
216_P	246_Y	1.170	1.00
208_V	231_L	1.170	1.00
189_E	210_L	1.162	1.00
234_A	249_T	1.155	1.00
234_A	246_Y	1.153	1.00
58_L	86_D	1.144	1.00
198_A	209_I	1.134	1.00
44_I	71_E	1.128	1.00
46_A	140_Y	1.126	1.00
242_N	245_D	1.113	0.99
118_V	248_K	1.109	0.99
189_E	208_V	1.107	0.99
195_Y	222_I	1.107	0.99
243_V	254_I	1.095	0.99
104_I	138_E	1.095	0.99
9_R	137_F	1.081	0.99
42_S	71_E	1.081	0.99
45_L	98_L	1.081	0.99
44_I	109_N	1.071	0.99
122_V	254_I	1.056	0.99
54_F	90_V	1.055	0.99
220_L	224_N	1.054	0.99
118_V	244_I	1.052	0.99
19_M	153_N	1.047	0.99
114_K	243_V	1.033	0.99
185_T	208_V	1.032	0.99
36_I	80_N	1.028	0.99
50_F	140_Y	1.028	0.99
166_T	193_S	1.025	0.99
216_P	245_D	1.023	0.99
187_I	208_V	1.020	0.99
103_G	263_Y	1.019	0.99
14_L	58_L	1.016	0.99
238_I	242_N	1.011	0.99
108_T	112_V	1.010	0.99
198_A	202_F	1.009	0.99
10_L	57_Y	1.008	0.99
118_V	122_V	1.007	0.99
107_I	111_M	1.006	0.99
10_L	97_F	1.004	0.99
7_V	11_L	1.001	0.99
68_D	144_V	0.991	0.99
52_V	64_N	0.983	0.99
49_R	52_V	0.974	0.99
242_N	246_Y	0.965	0.99
158_V	178_V	0.964	0.99
107_I	110_L	0.964	0.99
38_R	269_S	0.958	0.98
38_R	271_D	0.949	0.98
49_R	140_Y	0.946	0.98
51_I	94_I	0.934	0.98
24_T	159_L	0.931	0.98
217_Y	220_L	0.931	0.98
110_L	113_K	0.923	0.98
179_K	207_D	0.920	0.98
11_L	15_E	0.919	0.98
176_K	180_F	0.918	0.98
37_V	79_L	0.912	0.98
198_A	222_I	0.912	0.98
31_I	85_A	0.910	0.98
101_L	141_A	0.907	0.98
216_P	242_N	0.905	0.98
72_V	78_V	0.902	0.98
227_K	230_V	0.900	0.98
153_N	156_D	0.898	0.98
48_N	64_N	0.898	0.98
33_A	87_I	0.895	0.98
220_L	248_K	0.888	0.98
256_S	259_I	0.884	0.97
199_I	221_P	0.880	0.97
35_G	272_V	0.878	0.97
165_I	169_G	0.875	0.97
239_T	242_N	0.873	0.97
9_R	13_Y	0.869	0.97
237_G	256_S	0.866	0.97
216_P	249_T	0.863	0.97
62_N	79_L	0.863	0.97
195_Y	225_E	0.857	0.97
257_G	260_T	0.856	0.97
112_V	147_G	0.853	0.97
115_A	247_A	0.853	0.97
101_L	138_E	0.853	0.97
175_I	204_A	0.849	0.97
65_G	77_I	0.841	0.97
199_I	202_F	0.840	0.97
23_I	158_V	0.839	0.96
138_E	263_Y	0.834	0.96
32_R	84_D	0.832	0.96
50_F	137_F	0.822	0.96
257_G	261_H	0.820	0.96
193_S	271_D	0.819	0.96
198_A	225_E	0.818	0.96
243_V	256_S	0.812	0.96
33_A	167_L	0.810	0.96
48_N	52_V	0.803	0.95
194_S	197_D	0.803	0.95
221_P	225_E	0.801	0.95
97_F	134_F	0.797	0.95
10_L	13_Y	0.795	0.95
234_A	251_V	0.795	0.95
226_L	230_V	0.793	0.95
64_N	70_R	0.791	0.95
115_A	118_V	0.790	0.95
214_M	218_E	0.783	0.95
54_F	94_I	0.778	0.95
101_L	137_F	0.776	0.95
160_I	178_V	0.775	0.95
10_L	54_F	0.774	0.95
16_E	135_R	0.774	0.95
126_G	149_P	0.771	0.94
37_V	95_L	0.769	0.94
37_V	270_L	0.767	0.94
9_R	97_F	0.765	0.94
214_M	222_I	0.765	0.94
112_V	124_I	0.762	0.94
157_A	185_T	0.762	0.94
223_V	227_K	0.760	0.94
90_V	94_I	0.759	0.94
179_K	188_I	0.758	0.94
33_A	272_V	0.754	0.94
10_L	53_P	0.753	0.94
187_I	231_L	0.752	0.94
28_L	178_V	0.752	0.94
126_G	142_I	0.751	0.94
240_P	258_Y	0.749	0.93
223_V	249_T	0.748	0.93
39_C	78_V	0.746	0.93
195_Y	221_P	0.742	0.93
201_A	206_A	0.737	0.93
39_C	72_V	0.731	0.93
28_L	160_I	0.729	0.93
51_I	62_N	0.728	0.93
211_L	222_I	0.722	0.92
262_S	265_S	0.721	0.92
175_I	201_A	0.721	0.92
41_D	266_L	0.719	0.92
176_K	204_A	0.715	0.92
209_I	230_V	0.715	0.92
168_Y	177_R	0.712	0.92
166_T	272_V	0.711	0.92
170_N	200_R	0.708	0.91
27_F	181_S	0.704	0.91
85_A	167_L	0.703	0.91
202_F	230_V	0.702	0.91
203_K	229_K	0.702	0.91
195_Y	199_I	0.701	0.91
37_V	98_L	0.700	0.91
150_H	189_E	0.699	0.91
117_E	121_Y	0.698	0.91
61_S	84_D	0.696	0.91
115_A	243_V	0.696	0.91
201_A	204_A	0.695	0.91
202_F	226_L	0.693	0.91
98_L	268_F	0.693	0.91
48_N	68_D	0.692	0.91
189_E	207_D	0.691	0.90
39_C	43_G	0.690	0.90
219_I	249_T	0.688	0.90
196_E	200_R	0.686	0.90
217_Y	245_D	0.685	0.90
201_A	230_V	0.683	0.90
197_D	200_R	0.683	0.90
152_Y	155_S	0.679	0.90
177_R	180_F	0.678	0.90
45_L	102_S	0.678	0.90
223_V	250_G	0.672	0.89
210_L	219_I	0.666	0.89
121_Y	252_D	0.665	0.89
66_E	72_V	0.664	0.89
231_L	252_D	0.661	0.88
116_K	244_I	0.660	0.88
227_K	232_L	0.656	0.88
124_I	254_I	0.656	0.88
159_L	162_D	0.655	0.88
54_F	93_L	0.655	0.88
208_V	253_V	0.655	0.88
21_E	153_N	0.654	0.88
183_S	186_K	0.654	0.88
27_F	178_V	0.652	0.88
175_I	206_A	0.649	0.87
193_S	269_S	0.648	0.87
12_D	15_E	0.648	0.87
26_K	89_T	0.648	0.87
112_V	116_K	0.647	0.87
40_K	271_D	0.645	0.87
182_V	185_T	0.644	0.87
107_I	114_K	0.642	0.87
199_I	229_K	0.642	0.87
257_G	262_S	0.641	0.87
172_E	204_A	0.641	0.87
107_I	258_Y	0.630	0.86
55_L	90_V	0.629	0.86
225_E	229_K	0.628	0.86
37_V	81_F	0.626	0.86
219_I	223_V	0.623	0.85
83_G	87_I	0.619	0.85
38_R	77_I	0.619	0.85
162_D	213_N	0.615	0.85
125_A	185_T	0.615	0.85
234_A	250_G	0.613	0.84
97_F	137_F	0.613	0.84
54_F	97_F	0.613	0.84
124_I	256_S	0.611	0.84
51_I	54_F	0.611	0.84
50_F	101_L	0.610	0.84
41_D	74_K	0.609	0.84
81_F	90_V	0.608	0.84
66_E	78_V	0.608	0.84
47_G	102_S	0.606	0.84
43_G	72_V	0.605	0.84
244_I	247_A	0.598	0.83
115_A	248_K	0.598	0.83
217_Y	221_P	0.597	0.83
238_I	254_I	0.595	0.83
167_L	272_V	0.594	0.82
37_V	94_I	0.591	0.82
59_G	83_G	0.589	0.82
209_I	226_L	0.585	0.82
48_N	79_L	0.583	0.81
112_V	117_E	0.581	0.81
166_T	197_D	0.580	0.81
35_G	81_F	0.580	0.81
125_A	255_S	0.578	0.81
206_A	230_V	0.574	0.80
178_V	182_V	0.573	0.80
61_S	180_F	0.573	0.80
234_A	238_I	0.573	0.80
14_L	54_F	0.572	0.80
198_A	232_L	0.571	0.80
125_A	208_V	0.564	0.79
179_K	205_G	0.564	0.79
111_M	238_I	0.563	0.79
12_D	134_F	0.561	0.79
106_T	266_L	0.561	0.79
122_V	246_Y	0.561	0.79
260_T	265_S	0.560	0.79
83_G	86_D	0.558	0.78
162_D	193_S	0.558	0.78
125_A	231_L	0.557	0.78
109_N	116_K	0.553	0.78
190_V	206_A	0.553	0.78
165_I	168_Y	0.550	0.77
239_T	256_S	0.546	0.77
85_A	272_V	0.543	0.77
59_G	84_D	0.542	0.76
99_G	126_G	0.541	0.76
222_I	226_L	0.540	0.76
9_R	136_L	0.536	0.76
118_V	247_A	0.535	0.76
9_R	134_F	0.533	0.75
177_R	181_S	0.529	0.75
198_A	206_A	0.529	0.75
195_Y	198_A	0.529	0.75
240_P	244_I	0.529	0.75
256_S	260_T	0.529	0.75
211_L	214_M	0.528	0.75
237_G	262_S	0.526	0.74
125_A	157_A	0.526	0.74
7_V	56_K	0.525	0.74
260_T	263_Y	0.521	0.74
216_P	220_L	0.521	0.74
108_T	142_I	0.519	0.73
37_V	55_L	0.518	0.73
161_K	213_N	0.517	0.73
223_V	251_V	0.516	0.73
140_Y	143_E	0.516	0.73
197_D	269_S	0.514	0.73
131_T	263_Y	0.513	0.72
81_F	270_L	0.513	0.72
13_Y	93_L	0.513	0.72
112_V	145_G	0.513	0.72
211_L	226_L	0.512	0.72
64_N	67_K	0.510	0.72
72_V	266_L	0.510	0.72
192_V	210_L	0.509	0.72
48_N	67_K	0.509	0.72
20_P	153_N	0.507	0.72
88_L	213_N	0.506	0.71
116_K	121_Y	0.506	0.71
151_R	154_L	0.506	0.71
115_A	147_G	0.506	0.71
62_N	81_F	0.505	0.71
25_T	89_T	0.505	0.71
163_N	212_D	0.504	0.71
182_V	186_K	0.503	0.71
131_T	265_S	0.503	0.71
194_S	218_E	0.503	0.71
18_V	153_N	0.501	0.71
26_K	181_S	0.500	0.71
40_K	267_D	0.500	0.71

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3l0gA	3	0.9745	100	0.186	Contact Map
3pajA	2	0.9855	100	0.19	Contact Map
1qapA	2	0.9818	100	0.196	Contact Map
3gnnA	2	0.8945	100	0.204	Contact Map
2b7nA	6	0.9745	100	0.208	Contact Map
1qpoA	2	0.9782	100	0.219	Contact Map
2jbmA	5	1	100	0.221	Contact Map
3c2eA	5	0.92	100	0.224	Contact Map
1o4uA	2	0.9455	100	0.229	Contact Map
3tqvA	2	0.9818	100	0.232	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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