GREMLIN Database
Q97ZC6 - Nicotinate-nucleotide pyrophosphorylase [carboxylating]
UniProt: Q97ZC6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 275 (263)
Sequences: 3956 (2495)
Seq/√Len: 153.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
109_N113_K3.9541.00
215_K218_E3.1281.00
244_I248_K3.0791.00
43_G266_L2.9841.00
131_T138_E2.9611.00
11_L57_Y2.6661.00
192_V198_A2.6441.00
33_A85_A2.6371.00
7_V53_P2.6041.00
199_I225_E2.5681.00
108_T147_G2.4851.00
238_I246_Y2.4541.00
34_R82_E2.2811.00
65_G80_N2.2541.00
67_K70_R2.2401.00
66_E76_D2.2251.00
226_L232_L2.2171.00
45_L66_E2.1521.00
172_E200_R2.1441.00
193_S197_D2.0611.00
87_I270_L2.0341.00
46_A144_V2.0031.00
42_S73_K1.9631.00
78_V268_F1.9501.00
55_L94_I1.9111.00
199_I203_K1.8991.00
58_L90_V1.8951.00
8_K12_D1.8821.00
63_I80_N1.8491.00
59_G86_D1.8281.00
172_E176_K1.7921.00
142_I147_G1.7841.00
115_A124_I1.7741.00
218_E221_P1.7731.00
125_A253_V1.7541.00
113_K116_K1.7481.00
45_L72_V1.7371.00
140_Y144_V1.7211.00
34_R80_N1.6981.00
19_M155_S1.6911.00
219_I234_A1.6871.00
173_E176_K1.6841.00
175_I190_V1.6371.00
100_K131_T1.6341.00
111_M240_P1.6321.00
245_D248_K1.6281.00
170_N173_E1.6191.00
117_E244_I1.6101.00
9_R12_D1.5881.00
42_S74_K1.5861.00
110_L240_P1.5761.00
221_P224_N1.5751.00
114_K240_P1.5501.00
124_I243_V1.5471.00
107_I263_Y1.5281.00
231_L253_V1.5241.00
13_Y97_F1.5181.00
45_L48_N1.5141.00
37_V268_F1.5131.00
18_V89_T1.5111.00
32_R82_E1.5071.00
115_A122_V1.5031.00
118_V121_Y1.4951.00
123_R148_D1.4701.00
24_T160_I1.4641.00
111_M243_V1.4551.00
53_P56_K1.4511.00
219_I246_Y1.4451.00
173_E177_R1.4401.00
198_A226_L1.4331.00
111_M256_S1.4321.00
71_E109_N1.4301.00
99_G265_S1.4291.00
100_K138_E1.4231.00
71_E113_K1.4091.00
30_G84_D1.3861.00
53_P57_Y1.3791.00
73_K76_D1.3701.00
49_R68_D1.3691.00
52_V56_K1.3581.00
117_E248_K1.3541.00
20_P155_S1.3391.00
23_I186_K1.3341.00
45_L78_V1.3231.00
66_E70_R1.3121.00
158_V182_V1.2911.00
162_D271_D1.2861.00
107_I240_P1.2791.00
187_I207_D1.2731.00
7_V57_Y1.2681.00
51_I79_L1.2521.00
40_K269_S1.2511.00
114_K244_I1.2491.00
77_I80_N1.2491.00
8_K15_E1.2461.00
36_I77_I1.2381.00
172_E203_K1.2361.00
35_G270_L1.2331.00
41_D264_R1.2261.00
196_E199_I1.2251.00
8_K11_L1.2171.00
37_V51_I1.1921.00
63_I82_E1.1891.00
46_A105_A1.1871.00
216_P246_Y1.1701.00
208_V231_L1.1701.00
189_E210_L1.1621.00
234_A249_T1.1551.00
234_A246_Y1.1531.00
58_L86_D1.1441.00
198_A209_I1.1341.00
44_I71_E1.1281.00
46_A140_Y1.1261.00
242_N245_D1.1130.99
118_V248_K1.1090.99
189_E208_V1.1070.99
195_Y222_I1.1070.99
243_V254_I1.0950.99
104_I138_E1.0950.99
9_R137_F1.0810.99
42_S71_E1.0810.99
45_L98_L1.0810.99
44_I109_N1.0710.99
122_V254_I1.0560.99
54_F90_V1.0550.99
220_L224_N1.0540.99
118_V244_I1.0520.99
19_M153_N1.0470.99
114_K243_V1.0330.99
185_T208_V1.0320.99
36_I80_N1.0280.99
50_F140_Y1.0280.99
166_T193_S1.0250.99
216_P245_D1.0230.99
187_I208_V1.0200.99
103_G263_Y1.0190.99
14_L58_L1.0160.99
238_I242_N1.0110.99
108_T112_V1.0100.99
198_A202_F1.0090.99
10_L57_Y1.0080.99
118_V122_V1.0070.99
107_I111_M1.0060.99
10_L97_F1.0040.99
7_V11_L1.0010.99
68_D144_V0.9910.99
52_V64_N0.9830.99
49_R52_V0.9740.99
242_N246_Y0.9650.99
158_V178_V0.9640.99
107_I110_L0.9640.99
38_R269_S0.9580.98
38_R271_D0.9490.98
49_R140_Y0.9460.98
51_I94_I0.9340.98
24_T159_L0.9310.98
217_Y220_L0.9310.98
110_L113_K0.9230.98
179_K207_D0.9200.98
11_L15_E0.9190.98
176_K180_F0.9180.98
37_V79_L0.9120.98
198_A222_I0.9120.98
31_I85_A0.9100.98
101_L141_A0.9070.98
216_P242_N0.9050.98
72_V78_V0.9020.98
227_K230_V0.9000.98
153_N156_D0.8980.98
48_N64_N0.8980.98
33_A87_I0.8950.98
220_L248_K0.8880.98
256_S259_I0.8840.97
199_I221_P0.8800.97
35_G272_V0.8780.97
165_I169_G0.8750.97
239_T242_N0.8730.97
9_R13_Y0.8690.97
237_G256_S0.8660.97
216_P249_T0.8630.97
62_N79_L0.8630.97
195_Y225_E0.8570.97
257_G260_T0.8560.97
112_V147_G0.8530.97
115_A247_A0.8530.97
101_L138_E0.8530.97
175_I204_A0.8490.97
65_G77_I0.8410.97
199_I202_F0.8400.97
23_I158_V0.8390.96
138_E263_Y0.8340.96
32_R84_D0.8320.96
50_F137_F0.8220.96
257_G261_H0.8200.96
193_S271_D0.8190.96
198_A225_E0.8180.96
243_V256_S0.8120.96
33_A167_L0.8100.96
48_N52_V0.8030.95
194_S197_D0.8030.95
221_P225_E0.8010.95
97_F134_F0.7970.95
10_L13_Y0.7950.95
234_A251_V0.7950.95
226_L230_V0.7930.95
64_N70_R0.7910.95
115_A118_V0.7900.95
214_M218_E0.7830.95
54_F94_I0.7780.95
101_L137_F0.7760.95
160_I178_V0.7750.95
10_L54_F0.7740.95
16_E135_R0.7740.95
126_G149_P0.7710.94
37_V95_L0.7690.94
37_V270_L0.7670.94
9_R97_F0.7650.94
214_M222_I0.7650.94
112_V124_I0.7620.94
157_A185_T0.7620.94
223_V227_K0.7600.94
90_V94_I0.7590.94
179_K188_I0.7580.94
33_A272_V0.7540.94
10_L53_P0.7530.94
187_I231_L0.7520.94
28_L178_V0.7520.94
126_G142_I0.7510.94
240_P258_Y0.7490.93
223_V249_T0.7480.93
39_C78_V0.7460.93
195_Y221_P0.7420.93
201_A206_A0.7370.93
39_C72_V0.7310.93
28_L160_I0.7290.93
51_I62_N0.7280.93
211_L222_I0.7220.92
262_S265_S0.7210.92
175_I201_A0.7210.92
41_D266_L0.7190.92
176_K204_A0.7150.92
209_I230_V0.7150.92
168_Y177_R0.7120.92
166_T272_V0.7110.92
170_N200_R0.7080.91
27_F181_S0.7040.91
85_A167_L0.7030.91
202_F230_V0.7020.91
203_K229_K0.7020.91
195_Y199_I0.7010.91
37_V98_L0.7000.91
150_H189_E0.6990.91
117_E121_Y0.6980.91
61_S84_D0.6960.91
115_A243_V0.6960.91
201_A204_A0.6950.91
202_F226_L0.6930.91
98_L268_F0.6930.91
48_N68_D0.6920.91
189_E207_D0.6910.90
39_C43_G0.6900.90
219_I249_T0.6880.90
196_E200_R0.6860.90
217_Y245_D0.6850.90
201_A230_V0.6830.90
197_D200_R0.6830.90
152_Y155_S0.6790.90
177_R180_F0.6780.90
45_L102_S0.6780.90
223_V250_G0.6720.89
210_L219_I0.6660.89
121_Y252_D0.6650.89
66_E72_V0.6640.89
231_L252_D0.6610.88
116_K244_I0.6600.88
227_K232_L0.6560.88
124_I254_I0.6560.88
159_L162_D0.6550.88
54_F93_L0.6550.88
208_V253_V0.6550.88
21_E153_N0.6540.88
183_S186_K0.6540.88
27_F178_V0.6520.88
175_I206_A0.6490.87
193_S269_S0.6480.87
12_D15_E0.6480.87
26_K89_T0.6480.87
112_V116_K0.6470.87
40_K271_D0.6450.87
182_V185_T0.6440.87
107_I114_K0.6420.87
199_I229_K0.6420.87
257_G262_S0.6410.87
172_E204_A0.6410.87
107_I258_Y0.6300.86
55_L90_V0.6290.86
225_E229_K0.6280.86
37_V81_F0.6260.86
219_I223_V0.6230.85
83_G87_I0.6190.85
38_R77_I0.6190.85
162_D213_N0.6150.85
125_A185_T0.6150.85
234_A250_G0.6130.84
97_F137_F0.6130.84
54_F97_F0.6130.84
124_I256_S0.6110.84
51_I54_F0.6110.84
50_F101_L0.6100.84
41_D74_K0.6090.84
81_F90_V0.6080.84
66_E78_V0.6080.84
47_G102_S0.6060.84
43_G72_V0.6050.84
244_I247_A0.5980.83
115_A248_K0.5980.83
217_Y221_P0.5970.83
238_I254_I0.5950.83
167_L272_V0.5940.82
37_V94_I0.5910.82
59_G83_G0.5890.82
209_I226_L0.5850.82
48_N79_L0.5830.81
112_V117_E0.5810.81
166_T197_D0.5800.81
35_G81_F0.5800.81
125_A255_S0.5780.81
206_A230_V0.5740.80
178_V182_V0.5730.80
61_S180_F0.5730.80
234_A238_I0.5730.80
14_L54_F0.5720.80
198_A232_L0.5710.80
125_A208_V0.5640.79
179_K205_G0.5640.79
111_M238_I0.5630.79
12_D134_F0.5610.79
106_T266_L0.5610.79
122_V246_Y0.5610.79
260_T265_S0.5600.79
83_G86_D0.5580.78
162_D193_S0.5580.78
125_A231_L0.5570.78
109_N116_K0.5530.78
190_V206_A0.5530.78
165_I168_Y0.5500.77
239_T256_S0.5460.77
85_A272_V0.5430.77
59_G84_D0.5420.76
99_G126_G0.5410.76
222_I226_L0.5400.76
9_R136_L0.5360.76
118_V247_A0.5350.76
9_R134_F0.5330.75
177_R181_S0.5290.75
198_A206_A0.5290.75
195_Y198_A0.5290.75
240_P244_I0.5290.75
256_S260_T0.5290.75
211_L214_M0.5280.75
237_G262_S0.5260.74
125_A157_A0.5260.74
7_V56_K0.5250.74
260_T263_Y0.5210.74
216_P220_L0.5210.74
108_T142_I0.5190.73
37_V55_L0.5180.73
161_K213_N0.5170.73
223_V251_V0.5160.73
140_Y143_E0.5160.73
197_D269_S0.5140.73
131_T263_Y0.5130.72
81_F270_L0.5130.72
13_Y93_L0.5130.72
112_V145_G0.5130.72
211_L226_L0.5120.72
64_N67_K0.5100.72
72_V266_L0.5100.72
192_V210_L0.5090.72
48_N67_K0.5090.72
20_P153_N0.5070.72
88_L213_N0.5060.71
116_K121_Y0.5060.71
151_R154_L0.5060.71
115_A147_G0.5060.71
62_N81_F0.5050.71
25_T89_T0.5050.71
163_N212_D0.5040.71
182_V186_K0.5030.71
131_T265_S0.5030.71
194_S218_E0.5030.71
18_V153_N0.5010.71
26_K181_S0.5000.71
40_K267_D0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l0gA 3 0.9745 100 0.186 Contact Map
3pajA 2 0.9855 100 0.19 Contact Map
1qapA 2 0.9818 100 0.196 Contact Map
3gnnA 2 0.8945 100 0.204 Contact Map
2b7nA 6 0.9745 100 0.208 Contact Map
1qpoA 2 0.9782 100 0.219 Contact Map
2jbmA 5 1 100 0.221 Contact Map
3c2eA 5 0.92 100 0.224 Contact Map
1o4uA 2 0.9455 100 0.229 Contact Map
3tqvA 2 0.9818 100 0.232 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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