GREMLIN Database
NADB - L-aspartate oxidase
UniProt: Q97ZC5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 472 (371)
Sequences: 8739 (4577)
Seq/√Len: 237.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
317_N321_E5.1431.00
3_Y154_F3.9351.00
141_L194_I3.3831.00
195_A314_I2.9111.00
143_A155_I2.8771.00
75_D79_R2.7951.00
128_L131_K2.7901.00
143_A197_K2.7561.00
58_K75_D2.7271.00
291_S295_K2.6971.00
54_P79_R2.6941.00
201_L315_R2.6331.00
26_T137_I2.6161.00
14_A168_V2.6001.00
237_N241_E2.5991.00
328_Y362_Y2.5081.00
281_E291_S2.4901.00
319_R362_Y2.3731.00
30_K188_I2.3561.00
80_E358_N2.2331.00
69_C74_V2.1501.00
168_V363_I2.1381.00
76_Y358_N2.1351.00
156_T162_F2.1251.00
17_S361_R2.1071.00
28_I156_T2.1011.00
9_L352_D2.0791.00
137_I162_F2.0701.00
24_K135_N2.0681.00
155_I161_S2.0671.00
292_N296_R2.0471.00
30_K190_D2.0461.00
72_K318_T2.0321.00
9_L37_S2.0091.00
169_L195_A1.9681.00
171_T191_G1.9671.00
80_E83_Y1.9661.00
14_A330_I1.9311.00
237_N266_Q1.9151.00
137_I140_K1.8951.00
195_A200_A1.8781.00
169_L333_V1.8581.00
320_G359_L1.8521.00
10_A330_I1.8431.00
214_V306_G1.8281.00
3_Y162_F1.8101.00
19_H134_I1.7871.00
241_E246_K1.7631.00
129_A134_I1.7481.00
127_N131_K1.7311.00
164_A167_V1.7231.00
329_A333_V1.7071.00
5_F141_L1.7071.00
360_V364_D1.6901.00
144_L151_V1.6821.00
174_Y310_T1.6801.00
242_R252_E1.6781.00
142_L157_E1.6591.00
321_E362_Y1.6561.00
150_K325_K1.6431.00
261_R265_D1.6391.00
150_K326_G1.6381.00
245_F251_G1.6291.00
140_K156_T1.6211.00
77_V338_L1.6181.00
5_F154_F1.6021.00
18_L360_V1.5951.00
120_E123_N1.5781.00
359_L363_I1.5741.00
56_L107_K1.5731.00
224_L228_L1.5711.00
37_S122_T1.5691.00
84_V353_L1.5561.00
58_K78_T1.5311.00
18_L363_I1.5181.00
26_T162_F1.5111.00
202_V205_T1.4911.00
201_L323_N1.4891.00
5_F169_L1.4861.00
141_L154_F1.4721.00
171_T333_V1.4671.00
166_K366_W1.4631.00
129_A136_L1.4631.00
147_K152_A1.4601.00
203_S315_R1.4371.00
28_I154_F1.4321.00
147_K150_K1.4231.00
87_T357_V1.4231.00
54_P78_T1.4181.00
86_S90_K1.4161.00
4_I25_V1.4151.00
2_I18_L1.4131.00
362_Y366_W1.4111.00
234_I242_R1.4101.00
177_L180_F1.4041.00
126_L130_K1.3991.00
55_E59_I1.3981.00
356_G360_V1.3911.00
145_K155_I1.3891.00
58_K62_L1.3821.00
12_L129_A1.3801.00
71_S75_D1.3731.00
357_V361_R1.3591.00
54_P58_K1.3571.00
62_L71_S1.3571.00
17_S357_V1.3541.00
12_L27_I1.3391.00
149_G325_K1.3391.00
2_I168_V1.3351.00
128_L132_K1.3211.00
140_K158_K1.3161.00
280_I294_V1.3121.00
17_S21_S1.3061.00
83_Y86_S1.3051.00
146_V151_V1.2971.00
284_D291_S1.2951.00
236_V300_R1.2941.00
76_Y80_E1.2941.00
145_K153_G1.2891.00
77_V350_A1.2881.00
20_K90_K1.2851.00
77_V355_Y1.2821.00
84_V357_V1.2791.00
275_I286_K1.2781.00
21_S361_R1.2771.00
18_L23_Y1.2761.00
265_D269_K1.2761.00
20_K132_K1.2731.00
47_A54_P1.2731.00
170_A330_I1.2721.00
264_Y268_K1.2611.00
59_I63_E1.2591.00
265_D268_K1.2491.00
262_A265_D1.2351.00
314_I333_V1.2331.00
73_T318_T1.2321.00
76_Y318_T1.2301.00
2_I363_I1.2291.00
166_K367_E1.2181.00
278_S300_R1.2171.00
91_W128_L1.2141.00
362_Y365_N1.2101.00
56_L106_S1.1971.00
151_V167_V1.1901.00
192_I202_V1.1891.00
7_S27_I1.1871.00
168_V330_I1.1781.00
84_V87_T1.1771.00
17_S20_K1.1751.00
16_I129_A1.1701.00
58_K71_S1.1671.00
277_L282_D1.1651.00
282_D285_R1.1551.00
145_K161_S1.1541.00
3_Y164_A1.1541.00
145_K163_D1.1541.00
17_S360_V1.1431.00
169_L314_I1.1411.00
282_D286_K1.1371.00
65_G69_C1.1361.00
2_I23_Y1.1331.00
316_V329_A1.1301.00
266_Q269_K1.1251.00
15_A27_I1.1251.00
278_S282_D1.1191.00
147_K163_D1.1181.00
283_F300_R1.1171.00
62_L74_V1.1171.00
191_G194_I1.1121.00
56_L59_I1.1091.00
279_P282_D1.1021.00
277_L280_I1.1021.00
76_Y355_Y1.1011.00
328_Y366_W1.0931.00
277_L283_F1.0901.00
152_A163_D1.0881.00
145_K152_A1.0871.00
281_E285_R1.0851.00
319_R358_N1.0851.00
137_I158_K1.0801.00
55_E75_D1.0781.00
93_F124_F1.0771.00
16_I132_K1.0741.00
330_I359_L1.0731.00
58_K74_V1.0681.00
316_V334_T1.0671.00
80_E361_R1.0621.00
3_Y26_T1.0621.00
316_V320_G1.0551.00
83_Y357_V1.0461.00
73_T77_V1.0421.00
257_D260_S1.0391.00
31_K139_D1.0331.00
294_V298_G1.0241.00
14_A363_I1.0231.00
146_V149_G1.0231.00
15_A134_I1.0221.00
45_A346_S1.0201.00
19_H132_K1.0191.00
242_R245_F1.0171.00
86_S89_E1.0161.00
236_V278_S1.0151.00
241_E289_I1.0081.00
293_Y297_Y1.0061.00
19_H133_G1.0041.00
146_V198_A1.0031.00
16_I128_L1.0021.00
192_I310_T0.9981.00
180_F193_A0.9971.00
81_I350_A0.9971.00
3_Y28_I0.9971.00
196_F202_V0.9941.00
194_I197_K0.9871.00
28_I140_K0.9781.00
20_K91_W0.9681.00
309_Y348_S0.9681.00
146_V152_A0.9661.00
34_G39_W0.9631.00
84_V354_V0.9621.00
80_E357_V0.9621.00
177_L193_A0.9591.00
37_S352_D0.9561.00
120_E124_F0.9521.00
14_A359_L0.9501.00
326_G366_W0.9501.00
19_H24_K0.9491.00
234_I294_V0.9491.00
12_L122_T0.9481.00
21_S365_N0.9471.00
82_R86_S0.9461.00
73_T316_V0.9401.00
166_K363_I0.9401.00
235_L303_V0.9371.00
257_D261_R0.9371.00
24_K165_E0.9351.00
61_T74_V0.9331.00
266_Q271_H0.9321.00
165_E367_E0.9311.00
44_I85_V0.9301.00
321_E366_W0.9281.00
266_Q270_G0.9271.00
275_I287_F0.9251.00
174_Y208_V0.9191.00
87_T91_W0.9181.00
119_R123_N0.9131.00
23_Y363_I0.9101.00
140_K162_F0.9081.00
54_P75_D0.9041.00
27_I136_L0.9011.00
193_A197_K0.9011.00
261_R267_Y0.8961.00
141_L156_T0.8961.00
360_V363_I0.8951.00
36_S184_P0.8920.99
142_L155_I0.8850.99
277_L286_K0.8810.99
61_T347_N0.8760.99
62_L67_G0.8760.99
152_A155_I0.8730.99
7_S29_S0.8720.99
293_Y296_R0.8710.99
320_G358_N0.8690.99
17_S87_T0.8650.99
144_L167_V0.8650.99
13_S87_T0.8640.99
358_N362_Y0.8630.99
123_N127_N0.8560.99
169_L327_L0.8510.99
182_S214_V0.8500.99
175_G307_V0.8480.99
292_N295_K0.8440.99
47_A78_T0.8420.99
258_V261_R0.8380.99
22_G25_V0.8360.99
4_I15_A0.8330.99
40_A349_L0.8310.99
168_V359_L0.8300.99
21_S364_D0.8300.99
320_G355_Y0.8280.99
28_I162_F0.8230.99
361_R365_N0.8230.99
53_S56_L0.8180.99
194_I198_A0.8100.99
137_I156_T0.8090.99
263_I273_V0.8060.99
68_L341_A0.8040.99
322_S329_A0.8030.99
28_I141_L0.8020.99
23_Y364_D0.8020.99
290_L293_Y0.7990.99
143_A194_I0.7980.99
191_G195_A0.7970.99
166_K326_G0.7920.99
130_K138_E0.7920.99
267_Y270_G0.7900.99
143_A198_A0.7860.99
236_V290_L0.7820.99
16_I91_W0.7770.99
70_D315_R0.7760.99
151_V164_A0.7730.99
2_I360_V0.7720.99
80_E84_V0.7690.99
57_H347_N0.7680.98
101_L108_R0.7670.98
38_Y119_R0.7660.98
260_S265_D0.7640.98
20_K87_T0.7630.98
9_L353_L0.7600.98
144_L154_F0.7590.98
44_I353_L0.7490.98
234_I279_P0.7480.98
44_I350_A0.7440.98
93_F120_E0.7420.98
4_I14_A0.7410.98
122_T126_L0.7400.98
175_G181_T0.7390.98
203_S336_T0.7380.98
319_R365_N0.7380.98
308_H343_R0.7380.98
59_I62_L0.7330.98
13_S17_S0.7330.98
57_H61_T0.7310.98
27_I129_A0.7310.98
223_L226_E0.7300.98
191_G333_V0.7300.98
287_F300_R0.7280.98
2_I367_E0.7280.98
73_T338_L0.7250.98
246_K252_E0.7240.98
190_D193_A0.7220.98
99_L105_H0.7210.98
57_H78_T0.7210.98
23_Y360_V0.7170.98
363_I366_W0.7170.98
14_A18_L0.7160.98
21_S360_V0.7150.98
141_L191_G0.7150.98
62_L69_C0.7140.98
200_A324_I0.7140.98
18_L364_D0.7120.98
87_T90_K0.7120.98
109_R112_H0.7110.98
36_S187_N0.7110.98
10_A352_D0.7040.97
11_G170_A0.7040.97
14_A356_G0.7010.97
153_G167_V0.7000.97
85_V89_E0.7000.97
250_R254_A0.6990.97
5_F171_T0.6970.97
157_E160_G0.6920.97
316_V355_Y0.6910.97
330_I356_G0.6900.97
175_G187_N0.6870.97
16_I134_I0.6840.97
259_L262_A0.6840.97
46_A85_V0.6830.97
33_N126_L0.6830.97
370_S373_D0.6790.97
13_S84_V0.6770.97
325_K366_W0.6770.97
19_H135_N0.6760.97
113_K120_E0.6750.97
48_V111_L0.6740.97
28_I137_I0.6730.97
19_H364_D0.6710.96
192_I205_T0.6700.96
207_F341_A0.6650.96
26_T135_N0.6640.96
261_R268_K0.6610.96
332_E348_S0.6570.96
64_V342_N0.6570.96
96_D112_H0.6560.96
261_R264_Y0.6560.96
50_N86_S0.6560.96
59_I71_S0.6540.96
309_Y351_E0.6540.96
225_T228_L0.6530.96
242_R246_K0.6520.96
33_N138_E0.6520.96
363_I367_E0.6480.96
45_A105_H0.6430.96
89_E94_K0.6420.95
276_D286_K0.6400.95
100_R103_G0.6400.95
80_E354_V0.6390.95
110_I346_S0.6390.95
256_R260_S0.6380.95
243_F246_K0.6380.95
46_A81_I0.6370.95
314_I329_A0.6370.95
91_W124_F0.6350.95
116_D289_I0.6330.95
321_E325_K0.6330.95
174_Y192_I0.6320.95
284_D295_K0.6290.95
166_K328_Y0.6280.95
200_A327_L0.6280.95
4_I168_V0.6260.95
143_A146_V0.6250.95
47_A81_I0.6210.95
225_T290_L0.6200.95
246_K269_K0.6190.95
153_G327_L0.6190.95
102_E110_I0.6140.94
146_V150_K0.6120.94
52_D109_R0.6100.94
74_V78_T0.6080.94
242_R251_G0.6070.94
202_V314_I0.6060.94
7_S12_L0.6060.94
149_G324_I0.6050.94
193_A196_F0.6050.94
73_T336_T0.6040.94
279_P283_F0.6040.94
191_G198_A0.6030.94
165_E372_D0.6030.94
39_W184_P0.6000.94
44_I349_L0.5990.94
267_Y272_T0.5980.93
316_V336_T0.5980.93
289_I292_N0.5950.93
175_G183_N0.5940.93
68_L206_E0.5940.93
4_I363_I0.5930.93
18_L22_G0.5930.93
173_G310_T0.5920.93
7_S33_N0.5920.93
226_E230_G0.5920.93
55_E58_K0.5910.93
47_A57_H0.5900.93
260_S267_Y0.5900.93
17_S356_G0.5900.93
366_W370_S0.5890.93
274_Y300_R0.5860.93
165_E371_I0.5860.93
216_T272_T0.5850.93
231_E286_K0.5840.93
23_Y166_K0.5840.93
26_T165_E0.5840.93
283_F291_S0.5840.93
244_V256_R0.5820.93
267_Y271_H0.5820.93
154_F162_F0.5780.92
93_F121_I0.5780.92
54_P82_R0.5760.92
9_L125_L0.5750.92
261_R271_H0.5750.92
238_E270_G0.5740.92
234_I252_E0.5740.92
57_H60_D0.5730.92
243_F247_Y0.5730.92
3_Y167_V0.5720.92
19_H25_V0.5710.92
38_Y123_N0.5700.92
254_A258_V0.5700.92
44_I121_I0.5700.92
236_V242_R0.5700.92
238_E271_H0.5700.92
73_T76_Y0.5700.92
43_G226_E0.5690.92
13_S353_L0.5680.92
261_R266_Q0.5670.92
258_V264_Y0.5670.92
169_L191_G0.5660.91
205_T312_G0.5660.91
13_S356_G0.5640.91
253_L256_R0.5620.91
94_K120_E0.5600.91
243_F260_S0.5590.91
290_L294_V0.5580.91
24_K133_G0.5570.91
294_V297_Y0.5570.91
144_L169_L0.5570.91
223_L229_R0.5560.91
63_E67_G0.5550.91
29_S136_L0.5550.91
144_L198_A0.5540.91
214_V221_A0.5540.91
246_K266_Q0.5530.91
65_G74_V0.5520.90
217_F297_Y0.5520.90
127_N130_K0.5520.90
108_R111_L0.5510.90
23_Y367_E0.5510.90
330_I363_I0.5470.90
258_V262_A0.5470.90
29_S138_E0.5460.90
45_A57_H0.5460.90
338_L355_Y0.5460.90
100_R231_E0.5430.90
247_Y262_A0.5430.90
244_V254_A0.5430.90
76_Y319_R0.5420.90
146_V325_K0.5410.90
278_S281_E0.5410.90
70_D203_S0.5390.89
4_I19_H0.5390.89
7_S138_E0.5380.89
359_L362_Y0.5380.89
192_I333_V0.5380.89
329_A334_T0.5360.89
339_H344_L0.5350.89
317_N323_N0.5330.89
200_A323_N0.5330.89
198_A324_I0.5330.89
293_Y298_G0.5320.89
284_D290_L0.5310.89
32_I138_E0.5310.89
177_L189_G0.5300.89
151_V198_A0.5300.89
83_Y361_R0.5290.89
96_D114_T0.5280.88
66_D341_A0.5280.88
279_P284_D0.5270.88
168_V367_E0.5270.88
248_D255_P0.5250.88
68_L207_F0.5250.88
14_A360_V0.5250.88
233_A277_L0.5240.88
154_F167_V0.5240.88
261_R269_K0.5240.88
190_D194_I0.5230.88
308_H332_E0.5220.88
236_V276_D0.5220.88
151_V327_L0.5210.88
366_W369_L0.5180.87
33_N38_Y0.5170.87
20_K128_L0.5170.87
260_S271_H0.5170.87
34_G37_S0.5170.87
110_I113_K0.5160.87
360_V367_E0.5150.87
265_D270_G0.5140.87
354_V358_N0.5130.87
245_F249_S0.5130.87
124_F127_N0.5120.87
229_R232_G0.5120.87
182_S306_G0.5110.87
318_T358_N0.5100.87
244_V247_Y0.5090.87
57_H81_I0.5090.87
89_E97_D0.5090.87
276_D299_K0.5090.87
67_G74_V0.5080.86
18_L25_V0.5080.86
152_A325_K0.5080.86
247_Y265_D0.5060.86
368_G372_D0.5050.86
268_K271_H0.5050.86
226_E229_R0.5040.86
364_D367_E0.5020.86
180_F192_I0.5020.86
209_Q309_Y0.5010.86
61_T65_G0.5010.86
182_S308_H0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2bs2A 2 0.9958 100 0.251 Contact Map
1kf6A 1 0.9958 100 0.259 Contact Map
2h88A 2 0.9936 100 0.261 Contact Map
2wdqA 1 0.9915 100 0.265 Contact Map
2e5vA 1 0.9873 100 0.28 Contact Map
1chuA 2 0.8962 100 0.302 Contact Map
3gyxA 2 0.9661 100 0.348 Contact Map
1jnrA 2 0.9703 100 0.368 Contact Map
4c3xA 4 0.7627 100 0.474 Contact Map
4at0A 2 0.75 100 0.527 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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