NADA - SULSO - GREMLIN Contacts

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NADA - Quinolinate synthase A

UniProt:	Q97ZC4	Sequences: MTRVEELLSQIKNLKTEKNAIILGHNYMEYSVQLVSDFTGDSYDLAVKAMKTNAKIILFAGVYFMAEQASALNPNKKVLSPDPNAGCTLSDSLDVKTLQEYKEKYPNAPVVLYINTSIYAKALADYIVTSSTAVKVVQKLNADTILFGPDANLANYVQQKVPNKKIIKVPPNGRCIVHANYTKQLVELARKKYPNALLMAHPEAPLEILESADFVGSTNQMIQFSKENKNEEFIVATEIGMINALKIKNPSKKFYPLVTTEACACARCPYMNMINLEKVKRSLEEEVYEVKVPEDIAERVKRAFENTMKLL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	311 (297)
Sequences:	2254 (1180)
Seq/√Len:	68.5

ECOLI - NADA
BACSU - NADA
HALSA - NADA
SULSO - NADA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
19_N	55_K	5.024	1.00
10_Q	284_E	3.742	1.00
214_F	220_Q	3.055	1.00
232_E	253_K	3.042	1.00
305_E	309_K	3.015	1.00
294_E	297_A	2.812	1.00
195_N	232_E	2.802	1.00
200_A	209_L	2.786	1.00
223_Q	227_E	2.728	1.00
193_Y	232_E	2.723	1.00
13_N	17_E	2.718	1.00
99_Q	123_L	2.580	1.00
144_T	167_I	2.573	1.00
34_L	243_N	2.469	1.00
292_V	297_A	2.437	1.00
297_A	301_K	2.429	1.00
68_Q	304_F	2.416	1.00
56_I	286_E	2.414	1.00
154_A	170_P	2.351	1.00
294_E	298_E	2.351	1.00
77_K	286_E	2.336	1.00
77_K	289_E	2.313	1.00
10_Q	13_N	2.297	1.00
200_A	212_A	2.278	1.00
18_K	286_E	2.261	1.00
82_D	278_K	2.226	1.00
226_K	248_K	2.214	1.00
112_L	116_T	2.198	1.00
48_K	51_K	2.161	1.00
301_K	305_E	2.113	1.00
228_N	233_F	2.057	1.00
197_L	224_F	1.988	1.00
187_E	211_S	1.984	1.00
280_K	284_E	1.964	1.00
56_I	79_L	1.945	1.00
86_G	91_D	1.943	1.00
44_D	48_K	1.899	1.00
134_V	157_V	1.885	1.00
44_D	219_N	1.880	1.00
38_F	44_D	1.872	1.00
244_A	248_K	1.855	1.00
12_K	15_K	1.815	1.00
209_L	215_V	1.807	1.00
7_L	280_K	1.790	1.00
190_R	213_D	1.787	1.00
10_Q	280_K	1.784	1.00
226_K	249_N	1.776	1.00
18_K	56_I	1.762	1.00
197_L	230_N	1.760	1.00
112_L	124_A	1.736	1.00
221_M	245_L	1.720	1.00
100_E	103_E	1.709	1.00
50_M	73_N	1.704	1.00
231_E	251_S	1.697	1.00
183_K	211_S	1.685	1.00
282_S	288_Y	1.649	0.99
134_V	138_Q	1.622	0.99
306_N	309_K	1.608	0.99
187_E	191_K	1.586	0.99
59_F	69_A	1.569	0.99
197_L	228_N	1.535	0.99
70_S	289_E	1.523	0.99
225_S	254_F	1.518	0.99
126_Y	139_K	1.487	0.99
18_K	77_K	1.462	0.99
225_S	249_N	1.453	0.98
139_K	310_L	1.441	0.98
38_F	48_K	1.437	0.98
134_V	160_K	1.428	0.98
56_I	77_K	1.417	0.98
19_N	56_I	1.399	0.98
89_L	92_S	1.397	0.98
109_P	143_D	1.392	0.98
100_E	104_K	1.373	0.98
137_V	157_V	1.368	0.98
299_R	302_R	1.365	0.98
206_L	210_E	1.364	0.98
24_G	36_S	1.361	0.98
58_L	79_L	1.360	0.98
186_V	198_L	1.355	0.98
281_R	285_E	1.355	0.98
188_L	192_K	1.345	0.98
70_S	291_K	1.329	0.97
60_A	279_V	1.329	0.97
109_P	140_L	1.328	0.97
71_A	118_I	1.328	0.97
23_L	49_A	1.328	0.97
177_V	270_Y	1.326	0.97
99_Q	103_E	1.323	0.97
281_R	284_E	1.322	0.97
46_A	59_F	1.313	0.97
21_I	54_A	1.312	0.97
268_C	271_M	1.310	0.97
151_A	172_N	1.309	0.97
105_Y	169_V	1.297	0.97
105_Y	144_T	1.291	0.97
109_P	142_A	1.291	0.97
71_A	297_A	1.264	0.96
88_T	270_Y	1.252	0.96
231_E	253_K	1.251	0.96
8_L	12_K	1.236	0.96
199_M	235_V	1.228	0.96
193_Y	255_Y	1.226	0.96
223_Q	226_K	1.225	0.96
32_V	279_V	1.218	0.96
232_E	255_Y	1.205	0.95
200_A	236_A	1.199	0.95
199_M	225_S	1.195	0.95
159_Q	206_L	1.195	0.95
159_Q	210_E	1.172	0.94
46_A	73_N	1.172	0.94
135_K	138_Q	1.161	0.94
101_Y	146_L	1.134	0.93
45_L	59_F	1.132	0.93
138_Q	161_V	1.123	0.93
196_A	234_I	1.119	0.93
66_A	80_S	1.116	0.93
19_N	53_N	1.107	0.93
92_S	174_R	1.104	0.92
151_A	179_A	1.104	0.92
131_S	219_N	1.102	0.92
293_P	296_I	1.096	0.92
47_V	308_M	1.091	0.92
7_L	277_E	1.091	0.92
63_Y	86_G	1.085	0.92
219_N	223_Q	1.083	0.92
228_N	252_K	1.077	0.92
102_K	110_V	1.070	0.91
241_M	245_L	1.068	0.91
20_A	58_L	1.065	0.91
155_N	158_Q	1.063	0.91
58_L	279_V	1.060	0.91
43_Y	47_V	1.059	0.91
108_A	144_T	1.058	0.91
270_Y	273_M	1.051	0.91
120_A	148_G	1.049	0.90
19_N	54_A	1.048	0.90
112_L	148_G	1.046	0.90
181_Y	266_A	1.040	0.90
108_A	169_V	1.036	0.90
199_M	221_M	1.035	0.90
108_A	167_I	1.032	0.90
225_S	245_L	1.032	0.90
176_I	270_Y	1.027	0.89
95_V	120_A	1.019	0.89
136_V	310_L	1.015	0.89
94_D	97_T	1.014	0.89
190_R	211_S	1.010	0.89
114_I	127_I	1.007	0.89
80_S	290_V	1.005	0.88
216_G	221_M	1.004	0.88
30_Y	34_L	0.987	0.88
224_F	233_F	0.986	0.87
181_Y	257_L	0.979	0.87
183_K	187_E	0.967	0.86
233_F	252_K	0.966	0.86
239_I	256_P	0.965	0.86
93_L	120_A	0.963	0.86
156_Y	209_L	0.957	0.86
298_E	301_K	0.954	0.86
105_Y	108_A	0.950	0.85
44_D	47_V	0.940	0.85
95_V	119_Y	0.940	0.85
188_L	191_K	0.939	0.85
28_M	32_V	0.935	0.85
155_N	159_Q	0.933	0.84
88_T	174_R	0.928	0.84
14_L	17_E	0.921	0.84
70_S	292_V	0.921	0.84
98_L	148_G	0.921	0.84
20_A	56_I	0.920	0.84
155_N	206_L	0.919	0.83
111_V	136_V	0.919	0.83
24_G	33_Q	0.919	0.83
275_N	278_K	0.915	0.83
9_S	13_N	0.913	0.83
95_V	123_L	0.912	0.83
296_I	299_R	0.907	0.83
157_V	168_K	0.906	0.83
181_Y	265_C	0.902	0.82
47_V	51_K	0.901	0.82
124_A	303_A	0.900	0.82
83_P	288_Y	0.899	0.82
156_Y	215_V	0.892	0.82
116_T	199_M	0.890	0.81
295_D	299_R	0.888	0.81
184_Q	187_E	0.887	0.81
243_N	247_I	0.885	0.81
21_I	38_F	0.877	0.81
23_L	45_L	0.873	0.80
26_N	244_A	0.864	0.80
122_A	292_V	0.861	0.79
147_F	154_A	0.860	0.79
184_Q	188_L	0.860	0.79
12_K	16_T	0.858	0.79
155_N	209_L	0.858	0.79
79_L	286_E	0.857	0.79
8_L	34_L	0.855	0.79
73_N	124_A	0.854	0.79
116_T	174_R	0.854	0.79
234_I	257_L	0.854	0.79
88_T	176_I	0.853	0.79
249_N	252_K	0.844	0.78
77_K	291_K	0.843	0.78
189_A	234_I	0.843	0.78
198_L	236_A	0.841	0.78
107_N	144_T	0.840	0.78
177_V	180_N	0.840	0.78
53_N	56_I	0.833	0.77
7_L	276_L	0.831	0.77
21_I	52_T	0.830	0.77
298_E	302_R	0.827	0.76
26_N	216_G	0.826	0.76
131_S	223_Q	0.824	0.76
282_S	287_V	0.824	0.76
89_L	270_Y	0.824	0.76
189_A	255_Y	0.822	0.76
190_R	198_L	0.820	0.76
286_E	289_E	0.819	0.76
183_K	208_I	0.819	0.76
281_R	287_V	0.815	0.75
216_G	220_Q	0.814	0.75
302_R	306_N	0.807	0.75
250_P	254_F	0.806	0.75
20_A	283_L	0.805	0.75
43_Y	114_I	0.800	0.74
222_I	241_M	0.799	0.74
249_N	254_F	0.795	0.74
141_N	166_I	0.790	0.73
187_E	190_R	0.789	0.73
279_V	282_S	0.788	0.73
111_V	140_L	0.788	0.73
159_Q	209_L	0.780	0.72
183_K	207_E	0.774	0.72
79_L	282_S	0.771	0.71
133_A	153_L	0.770	0.71
88_T	177_V	0.769	0.71
28_M	66_A	0.769	0.71
34_L	247_I	0.760	0.70
18_K	283_L	0.757	0.70
144_T	169_V	0.757	0.70
30_Y	243_N	0.756	0.70
112_L	303_A	0.752	0.69
82_D	273_M	0.749	0.69
33_Q	243_N	0.744	0.69
246_K	253_K	0.741	0.68
110_V	146_L	0.739	0.68
162_P	168_K	0.739	0.68
199_M	233_F	0.739	0.68
196_A	232_E	0.736	0.68
71_A	300_V	0.735	0.68
93_L	171_P	0.734	0.68
245_L	254_F	0.733	0.67
224_F	228_N	0.731	0.67
88_T	265_C	0.730	0.67
89_L	176_I	0.730	0.67
22_I	60_A	0.729	0.67
195_N	231_E	0.729	0.67
176_I	181_Y	0.727	0.67
292_V	296_I	0.724	0.66
146_L	169_V	0.723	0.66
244_A	247_I	0.718	0.66
123_L	299_R	0.716	0.66
44_D	131_S	0.716	0.66
174_R	179_A	0.714	0.65
131_S	221_M	0.709	0.65
277_E	281_R	0.709	0.65
101_Y	105_Y	0.708	0.65
221_M	241_M	0.707	0.65
58_L	81_P	0.706	0.65
26_N	241_M	0.704	0.64
98_L	102_K	0.704	0.64
114_I	136_V	0.703	0.64
102_K	125_D	0.702	0.64
278_K	281_R	0.702	0.64
126_Y	140_L	0.700	0.64
197_L	200_A	0.700	0.64
101_Y	108_A	0.700	0.64
15_K	37_D	0.697	0.64
142_A	145_I	0.693	0.63
95_V	99_Q	0.693	0.63
43_Y	131_S	0.691	0.63
57_I	69_A	0.691	0.63
143_D	167_I	0.688	0.63
32_V	274_I	0.688	0.63
236_A	257_L	0.686	0.62
162_P	166_I	0.684	0.62
268_C	274_I	0.684	0.62
158_Q	168_K	0.682	0.62
28_M	36_S	0.679	0.62
6_E	9_S	0.679	0.62
36_S	39_T	0.677	0.61
189_A	193_Y	0.675	0.61
82_D	274_I	0.674	0.61
73_N	76_K	0.674	0.61
111_V	126_Y	0.672	0.61
47_V	220_Q	0.672	0.61
66_A	102_K	0.671	0.61
84_N	273_M	0.669	0.60
92_S	173_G	0.667	0.60
6_E	10_Q	0.665	0.60
9_S	191_K	0.664	0.60
189_A	192_K	0.664	0.60
292_V	301_K	0.664	0.60
26_N	221_M	0.663	0.60
89_L	174_R	0.662	0.60
93_L	148_G	0.660	0.59
158_Q	170_P	0.660	0.59
109_P	145_I	0.659	0.59
103_E	123_L	0.658	0.59
292_V	303_A	0.656	0.59
268_C	275_N	0.655	0.59
177_V	181_Y	0.651	0.58
177_V	269_P	0.647	0.58
9_S	12_K	0.646	0.58
15_K	22_I	0.645	0.58
156_Y	170_P	0.644	0.57
136_V	309_K	0.644	0.57
221_M	235_V	0.642	0.57
285_E	288_Y	0.639	0.57
111_V	128_V	0.637	0.57
242_I	246_K	0.636	0.57
102_K	123_L	0.635	0.56
23_L	59_F	0.631	0.56
16_T	231_E	0.630	0.56
98_L	123_L	0.624	0.55
102_K	146_L	0.623	0.55
71_A	292_V	0.619	0.55
296_I	303_A	0.618	0.54
86_G	89_L	0.617	0.54
33_Q	39_T	0.616	0.54
10_Q	281_R	0.615	0.54
267_R	272_N	0.614	0.54
271_M	275_N	0.613	0.54
38_F	222_I	0.612	0.54
267_R	270_Y	0.611	0.54
208_I	213_D	0.608	0.53
128_V	132_T	0.608	0.53
228_N	231_E	0.607	0.53
97_T	100_E	0.606	0.53
280_K	285_E	0.605	0.53
112_L	127_I	0.601	0.52
124_A	148_G	0.599	0.52
114_I	124_A	0.599	0.52
94_D	98_L	0.596	0.52
106_P	144_T	0.596	0.52
88_T	92_S	0.595	0.52
71_A	301_K	0.593	0.51
95_V	122_A	0.591	0.51
151_A	174_R	0.590	0.51
58_L	282_S	0.589	0.51
271_M	274_I	0.587	0.51
98_L	101_Y	0.586	0.51
283_L	286_E	0.585	0.50
122_A	296_I	0.583	0.50
33_Q	240_G	0.583	0.50
63_Y	90_S	0.582	0.50
114_I	310_L	0.581	0.50
126_Y	310_L	0.580	0.50
20_A	79_L	0.579	0.50
97_T	101_Y	0.577	0.49
235_V	245_L	0.577	0.49
28_M	80_S	0.575	0.49
98_L	110_V	0.574	0.49
137_V	145_I	0.572	0.49
167_I	171_P	0.570	0.49
109_P	154_A	0.569	0.49
156_Y	160_K	0.568	0.48
98_L	120_A	0.568	0.48
118_I	292_V	0.566	0.48
11_I	280_K	0.566	0.48
154_A	168_K	0.566	0.48
55_K	75_N	0.565	0.48
107_N	143_D	0.565	0.48
256_P	266_A	0.563	0.48
269_P	273_M	0.563	0.48
143_D	166_I	0.563	0.48
63_Y	91_D	0.563	0.48
24_G	32_V	0.563	0.48
180_N	269_P	0.561	0.48
109_P	166_I	0.559	0.47
186_V	236_A	0.557	0.47
225_S	233_F	0.556	0.47
120_A	171_P	0.556	0.47
88_T	181_Y	0.556	0.47
101_Y	168_K	0.554	0.47
295_D	298_E	0.552	0.46
156_Y	159_Q	0.551	0.46
29_E	32_V	0.546	0.46
142_A	166_I	0.544	0.46
105_Y	146_L	0.541	0.45
96_K	100_E	0.541	0.45
122_A	300_V	0.540	0.45
140_L	145_I	0.539	0.45
63_Y	292_V	0.537	0.45
110_V	124_A	0.537	0.45
241_M	244_A	0.535	0.44
182_T	185_L	0.533	0.44
282_S	286_E	0.532	0.44
12_K	22_I	0.531	0.44
99_Q	102_K	0.530	0.44
108_A	146_L	0.529	0.44
235_V	273_M	0.528	0.44
52_T	114_I	0.527	0.44
193_Y	253_K	0.527	0.44
114_I	274_I	0.526	0.43
265_C	270_Y	0.525	0.43
92_S	270_Y	0.525	0.43
258_V	266_A	0.524	0.43
50_M	305_E	0.524	0.43
265_C	269_P	0.523	0.43
146_L	173_G	0.523	0.43
268_C	272_N	0.522	0.43
43_Y	68_Q	0.522	0.43
184_Q	295_D	0.522	0.43
216_G	244_A	0.521	0.43
302_R	309_K	0.519	0.43
179_A	205_P	0.519	0.43
35_V	267_R	0.517	0.42
26_N	154_A	0.516	0.42
225_S	235_V	0.516	0.42
51_K	227_E	0.515	0.42
197_L	233_F	0.515	0.42
220_Q	225_S	0.515	0.42
128_V	145_I	0.514	0.42
80_S	83_P	0.514	0.42
158_Q	167_I	0.514	0.42
177_V	266_A	0.513	0.42
105_Y	142_A	0.511	0.42
71_A	299_R	0.511	0.42
24_G	60_A	0.510	0.42
93_L	98_L	0.509	0.41
21_I	56_I	0.509	0.41
127_I	166_I	0.508	0.41
206_L	209_L	0.508	0.41
140_L	158_Q	0.508	0.41
185_L	264_A	0.507	0.41
242_I	256_P	0.507	0.41
29_E	272_N	0.507	0.41
229_K	252_K	0.505	0.41
174_R	270_Y	0.503	0.41
268_C	277_E	0.502	0.41
43_Y	308_M	0.501	0.40
80_S	274_I	0.500	0.40
97_T	171_P	0.500	0.40
138_Q	141_N	0.500	0.40

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1wzuA	1	0.8714	100	0.11	Contact Map
4p3xA	1	0.9678	100	0.121	Contact Map
2ekcA	1	0.7138	72	0.969	Contact Map
2q5cA	2	0.5402	55	0.972	Contact Map
1tqxA	2	0.6141	43.5	0.974	Contact Map
4ht3A	1	0.7621	41.1	0.974	Contact Map
1wa3A	3	0.6109	40.8	0.974	Contact Map
3fzqA	2	0.4116	36.1	0.975	Contact Map
3navA	2	0.7395	33.2	0.975	Contact Map
4mwaA	4	0.6463	32.9	0.975	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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