GREMLIN Database
NADA - Quinolinate synthase A
UniProt: Q97ZC4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 311 (297)
Sequences: 2254 (1180)
Seq/√Len: 68.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_N55_K5.0241.00
10_Q284_E3.7421.00
214_F220_Q3.0551.00
232_E253_K3.0421.00
305_E309_K3.0151.00
294_E297_A2.8121.00
195_N232_E2.8021.00
200_A209_L2.7861.00
223_Q227_E2.7281.00
193_Y232_E2.7231.00
13_N17_E2.7181.00
99_Q123_L2.5801.00
144_T167_I2.5731.00
34_L243_N2.4691.00
292_V297_A2.4371.00
297_A301_K2.4291.00
68_Q304_F2.4161.00
56_I286_E2.4141.00
154_A170_P2.3511.00
294_E298_E2.3511.00
77_K286_E2.3361.00
77_K289_E2.3131.00
10_Q13_N2.2971.00
200_A212_A2.2781.00
18_K286_E2.2611.00
82_D278_K2.2261.00
226_K248_K2.2141.00
112_L116_T2.1981.00
48_K51_K2.1611.00
301_K305_E2.1131.00
228_N233_F2.0571.00
197_L224_F1.9881.00
187_E211_S1.9841.00
280_K284_E1.9641.00
56_I79_L1.9451.00
86_G91_D1.9431.00
44_D48_K1.8991.00
134_V157_V1.8851.00
44_D219_N1.8801.00
38_F44_D1.8721.00
244_A248_K1.8551.00
12_K15_K1.8151.00
209_L215_V1.8071.00
7_L280_K1.7901.00
190_R213_D1.7871.00
10_Q280_K1.7841.00
226_K249_N1.7761.00
18_K56_I1.7621.00
197_L230_N1.7601.00
112_L124_A1.7361.00
221_M245_L1.7201.00
100_E103_E1.7091.00
50_M73_N1.7041.00
231_E251_S1.6971.00
183_K211_S1.6851.00
282_S288_Y1.6490.99
134_V138_Q1.6220.99
306_N309_K1.6080.99
187_E191_K1.5860.99
59_F69_A1.5690.99
197_L228_N1.5350.99
70_S289_E1.5230.99
225_S254_F1.5180.99
126_Y139_K1.4870.99
18_K77_K1.4620.99
225_S249_N1.4530.98
139_K310_L1.4410.98
38_F48_K1.4370.98
134_V160_K1.4280.98
56_I77_K1.4170.98
19_N56_I1.3990.98
89_L92_S1.3970.98
109_P143_D1.3920.98
100_E104_K1.3730.98
137_V157_V1.3680.98
299_R302_R1.3650.98
206_L210_E1.3640.98
24_G36_S1.3610.98
58_L79_L1.3600.98
186_V198_L1.3550.98
281_R285_E1.3550.98
188_L192_K1.3450.98
70_S291_K1.3290.97
60_A279_V1.3290.97
109_P140_L1.3280.97
71_A118_I1.3280.97
23_L49_A1.3280.97
177_V270_Y1.3260.97
99_Q103_E1.3230.97
281_R284_E1.3220.97
46_A59_F1.3130.97
21_I54_A1.3120.97
268_C271_M1.3100.97
151_A172_N1.3090.97
105_Y169_V1.2970.97
105_Y144_T1.2910.97
109_P142_A1.2910.97
71_A297_A1.2640.96
88_T270_Y1.2520.96
231_E253_K1.2510.96
8_L12_K1.2360.96
199_M235_V1.2280.96
193_Y255_Y1.2260.96
223_Q226_K1.2250.96
32_V279_V1.2180.96
232_E255_Y1.2050.95
200_A236_A1.1990.95
199_M225_S1.1950.95
159_Q206_L1.1950.95
159_Q210_E1.1720.94
46_A73_N1.1720.94
135_K138_Q1.1610.94
101_Y146_L1.1340.93
45_L59_F1.1320.93
138_Q161_V1.1230.93
196_A234_I1.1190.93
66_A80_S1.1160.93
19_N53_N1.1070.93
92_S174_R1.1040.92
151_A179_A1.1040.92
131_S219_N1.1020.92
293_P296_I1.0960.92
47_V308_M1.0910.92
7_L277_E1.0910.92
63_Y86_G1.0850.92
219_N223_Q1.0830.92
228_N252_K1.0770.92
102_K110_V1.0700.91
241_M245_L1.0680.91
20_A58_L1.0650.91
155_N158_Q1.0630.91
58_L279_V1.0600.91
43_Y47_V1.0590.91
108_A144_T1.0580.91
270_Y273_M1.0510.91
120_A148_G1.0490.90
19_N54_A1.0480.90
112_L148_G1.0460.90
181_Y266_A1.0400.90
108_A169_V1.0360.90
199_M221_M1.0350.90
108_A167_I1.0320.90
225_S245_L1.0320.90
176_I270_Y1.0270.89
95_V120_A1.0190.89
136_V310_L1.0150.89
94_D97_T1.0140.89
190_R211_S1.0100.89
114_I127_I1.0070.89
80_S290_V1.0050.88
216_G221_M1.0040.88
30_Y34_L0.9870.88
224_F233_F0.9860.87
181_Y257_L0.9790.87
183_K187_E0.9670.86
233_F252_K0.9660.86
239_I256_P0.9650.86
93_L120_A0.9630.86
156_Y209_L0.9570.86
298_E301_K0.9540.86
105_Y108_A0.9500.85
44_D47_V0.9400.85
95_V119_Y0.9400.85
188_L191_K0.9390.85
28_M32_V0.9350.85
155_N159_Q0.9330.84
88_T174_R0.9280.84
14_L17_E0.9210.84
70_S292_V0.9210.84
98_L148_G0.9210.84
20_A56_I0.9200.84
155_N206_L0.9190.83
111_V136_V0.9190.83
24_G33_Q0.9190.83
275_N278_K0.9150.83
9_S13_N0.9130.83
95_V123_L0.9120.83
296_I299_R0.9070.83
157_V168_K0.9060.83
181_Y265_C0.9020.82
47_V51_K0.9010.82
124_A303_A0.9000.82
83_P288_Y0.8990.82
156_Y215_V0.8920.82
116_T199_M0.8900.81
295_D299_R0.8880.81
184_Q187_E0.8870.81
243_N247_I0.8850.81
21_I38_F0.8770.81
23_L45_L0.8730.80
26_N244_A0.8640.80
122_A292_V0.8610.79
147_F154_A0.8600.79
184_Q188_L0.8600.79
12_K16_T0.8580.79
155_N209_L0.8580.79
79_L286_E0.8570.79
8_L34_L0.8550.79
73_N124_A0.8540.79
116_T174_R0.8540.79
234_I257_L0.8540.79
88_T176_I0.8530.79
249_N252_K0.8440.78
77_K291_K0.8430.78
189_A234_I0.8430.78
198_L236_A0.8410.78
107_N144_T0.8400.78
177_V180_N0.8400.78
53_N56_I0.8330.77
7_L276_L0.8310.77
21_I52_T0.8300.77
298_E302_R0.8270.76
26_N216_G0.8260.76
131_S223_Q0.8240.76
282_S287_V0.8240.76
89_L270_Y0.8240.76
189_A255_Y0.8220.76
190_R198_L0.8200.76
286_E289_E0.8190.76
183_K208_I0.8190.76
281_R287_V0.8150.75
216_G220_Q0.8140.75
302_R306_N0.8070.75
250_P254_F0.8060.75
20_A283_L0.8050.75
43_Y114_I0.8000.74
222_I241_M0.7990.74
249_N254_F0.7950.74
141_N166_I0.7900.73
187_E190_R0.7890.73
279_V282_S0.7880.73
111_V140_L0.7880.73
159_Q209_L0.7800.72
183_K207_E0.7740.72
79_L282_S0.7710.71
133_A153_L0.7700.71
88_T177_V0.7690.71
28_M66_A0.7690.71
34_L247_I0.7600.70
18_K283_L0.7570.70
144_T169_V0.7570.70
30_Y243_N0.7560.70
112_L303_A0.7520.69
82_D273_M0.7490.69
33_Q243_N0.7440.69
246_K253_K0.7410.68
110_V146_L0.7390.68
162_P168_K0.7390.68
199_M233_F0.7390.68
196_A232_E0.7360.68
71_A300_V0.7350.68
93_L171_P0.7340.68
245_L254_F0.7330.67
224_F228_N0.7310.67
88_T265_C0.7300.67
89_L176_I0.7300.67
22_I60_A0.7290.67
195_N231_E0.7290.67
176_I181_Y0.7270.67
292_V296_I0.7240.66
146_L169_V0.7230.66
244_A247_I0.7180.66
123_L299_R0.7160.66
44_D131_S0.7160.66
174_R179_A0.7140.65
131_S221_M0.7090.65
277_E281_R0.7090.65
101_Y105_Y0.7080.65
221_M241_M0.7070.65
58_L81_P0.7060.65
26_N241_M0.7040.64
98_L102_K0.7040.64
114_I136_V0.7030.64
102_K125_D0.7020.64
278_K281_R0.7020.64
126_Y140_L0.7000.64
197_L200_A0.7000.64
101_Y108_A0.7000.64
15_K37_D0.6970.64
142_A145_I0.6930.63
95_V99_Q0.6930.63
43_Y131_S0.6910.63
57_I69_A0.6910.63
143_D167_I0.6880.63
32_V274_I0.6880.63
236_A257_L0.6860.62
162_P166_I0.6840.62
268_C274_I0.6840.62
158_Q168_K0.6820.62
28_M36_S0.6790.62
6_E9_S0.6790.62
36_S39_T0.6770.61
189_A193_Y0.6750.61
82_D274_I0.6740.61
73_N76_K0.6740.61
111_V126_Y0.6720.61
47_V220_Q0.6720.61
66_A102_K0.6710.61
84_N273_M0.6690.60
92_S173_G0.6670.60
6_E10_Q0.6650.60
9_S191_K0.6640.60
189_A192_K0.6640.60
292_V301_K0.6640.60
26_N221_M0.6630.60
89_L174_R0.6620.60
93_L148_G0.6600.59
158_Q170_P0.6600.59
109_P145_I0.6590.59
103_E123_L0.6580.59
292_V303_A0.6560.59
268_C275_N0.6550.59
177_V181_Y0.6510.58
177_V269_P0.6470.58
9_S12_K0.6460.58
15_K22_I0.6450.58
156_Y170_P0.6440.57
136_V309_K0.6440.57
221_M235_V0.6420.57
285_E288_Y0.6390.57
111_V128_V0.6370.57
242_I246_K0.6360.57
102_K123_L0.6350.56
23_L59_F0.6310.56
16_T231_E0.6300.56
98_L123_L0.6240.55
102_K146_L0.6230.55
71_A292_V0.6190.55
296_I303_A0.6180.54
86_G89_L0.6170.54
33_Q39_T0.6160.54
10_Q281_R0.6150.54
267_R272_N0.6140.54
271_M275_N0.6130.54
38_F222_I0.6120.54
267_R270_Y0.6110.54
208_I213_D0.6080.53
128_V132_T0.6080.53
228_N231_E0.6070.53
97_T100_E0.6060.53
280_K285_E0.6050.53
112_L127_I0.6010.52
124_A148_G0.5990.52
114_I124_A0.5990.52
94_D98_L0.5960.52
106_P144_T0.5960.52
88_T92_S0.5950.52
71_A301_K0.5930.51
95_V122_A0.5910.51
151_A174_R0.5900.51
58_L282_S0.5890.51
271_M274_I0.5870.51
98_L101_Y0.5860.51
283_L286_E0.5850.50
122_A296_I0.5830.50
33_Q240_G0.5830.50
63_Y90_S0.5820.50
114_I310_L0.5810.50
126_Y310_L0.5800.50
20_A79_L0.5790.50
97_T101_Y0.5770.49
235_V245_L0.5770.49
28_M80_S0.5750.49
98_L110_V0.5740.49
137_V145_I0.5720.49
167_I171_P0.5700.49
109_P154_A0.5690.49
156_Y160_K0.5680.48
98_L120_A0.5680.48
118_I292_V0.5660.48
11_I280_K0.5660.48
154_A168_K0.5660.48
55_K75_N0.5650.48
107_N143_D0.5650.48
256_P266_A0.5630.48
269_P273_M0.5630.48
143_D166_I0.5630.48
63_Y91_D0.5630.48
24_G32_V0.5630.48
180_N269_P0.5610.48
109_P166_I0.5590.47
186_V236_A0.5570.47
225_S233_F0.5560.47
120_A171_P0.5560.47
88_T181_Y0.5560.47
101_Y168_K0.5540.47
295_D298_E0.5520.46
156_Y159_Q0.5510.46
29_E32_V0.5460.46
142_A166_I0.5440.46
105_Y146_L0.5410.45
96_K100_E0.5410.45
122_A300_V0.5400.45
140_L145_I0.5390.45
63_Y292_V0.5370.45
110_V124_A0.5370.45
241_M244_A0.5350.44
182_T185_L0.5330.44
282_S286_E0.5320.44
12_K22_I0.5310.44
99_Q102_K0.5300.44
108_A146_L0.5290.44
235_V273_M0.5280.44
52_T114_I0.5270.44
193_Y253_K0.5270.44
114_I274_I0.5260.43
265_C270_Y0.5250.43
92_S270_Y0.5250.43
258_V266_A0.5240.43
50_M305_E0.5240.43
265_C269_P0.5230.43
146_L173_G0.5230.43
268_C272_N0.5220.43
43_Y68_Q0.5220.43
184_Q295_D0.5220.43
216_G244_A0.5210.43
302_R309_K0.5190.43
179_A205_P0.5190.43
35_V267_R0.5170.42
26_N154_A0.5160.42
225_S235_V0.5160.42
51_K227_E0.5150.42
197_L233_F0.5150.42
220_Q225_S0.5150.42
128_V145_I0.5140.42
80_S83_P0.5140.42
158_Q167_I0.5140.42
177_V266_A0.5130.42
105_Y142_A0.5110.42
71_A299_R0.5110.42
24_G60_A0.5100.42
93_L98_L0.5090.41
21_I56_I0.5090.41
127_I166_I0.5080.41
206_L209_L0.5080.41
140_L158_Q0.5080.41
185_L264_A0.5070.41
242_I256_P0.5070.41
29_E272_N0.5070.41
229_K252_K0.5050.41
174_R270_Y0.5030.41
268_C277_E0.5020.41
43_Y308_M0.5010.40
80_S274_I0.5000.40
97_T171_P0.5000.40
138_Q141_N0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wzuA 1 0.8714 100 0.11 Contact Map
4p3xA 1 0.9678 100 0.121 Contact Map
2ekcA 1 0.7138 72 0.969 Contact Map
2q5cA 2 0.5402 55 0.972 Contact Map
1tqxA 2 0.6141 43.5 0.974 Contact Map
4ht3A 1 0.7621 41.1 0.974 Contact Map
1wa3A 3 0.6109 40.8 0.974 Contact Map
3fzqA 2 0.4116 36.1 0.975 Contact Map
3navA 2 0.7395 33.2 0.975 Contact Map
4mwaA 4 0.6463 32.9 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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