GREMLIN Database
Q97ZC2 - Maltose transport inner membrane protein
UniProt: Q97ZC2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 275 (244)
Sequences: 71320 (45547)
Seq/√Len: 2915.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
189_R193_Y4.1841.00
60_I64_V3.3181.00
166_L170_S3.0371.00
181_A190_R2.9991.00
86_R177_Y2.7261.00
34_S47_Y2.6941.00
177_Y195_T2.6851.00
57_S60_I2.6331.00
180_S190_R2.6241.00
168_G202_F2.5951.00
68_G150_M2.5311.00
186_G189_R2.5291.00
72_I154_S2.4951.00
45_Y48_K2.4421.00
70_L207_L2.4091.00
56_S60_I2.3641.00
187_P190_R2.3171.00
188_I192_F2.2981.00
45_Y49_E2.2881.00
165_L203_I2.2711.00
246_E249_L2.2351.00
48_K51_S2.2211.00
88_F91_K2.1721.00
185_A189_R2.1381.00
189_R192_F2.0881.00
78_F191_F2.0661.00
161_V206_S2.0311.00
169_M199_L1.9831.00
85_S170_S1.9741.00
176_L198_N1.9061.00
32_Y36_Q1.8781.00
180_S185_A1.8741.00
64_V146_L1.8611.00
74_L207_L1.8601.00
95_S166_L1.8411.00
78_F199_L1.8131.00
177_Y190_R1.7981.00
181_A187_P1.7881.00
66_T211_G1.7611.00
57_S61_N1.7451.00
238_D242_T1.7361.00
28_I32_Y1.7091.00
77_G161_V1.6901.00
266_G270_K1.6691.00
84_L162_A1.6631.00
177_Y181_A1.6311.00
69_A214_E1.6311.00
78_F165_L1.6181.00
64_V68_G1.6131.00
80_V162_A1.6111.00
49_E249_L1.6031.00
31_V255_T1.5981.00
87_E91_K1.5531.00
161_V210_R1.5401.00
25_F29_E1.5161.00
81_A165_L1.4811.00
174_K177_Y1.4771.00
58_A236_I1.4691.00
13_L17_A1.4691.00
75_A79_L1.4681.00
90_G93_A1.4521.00
43_S46_N1.4331.00
196_L203_I1.4271.00
85_S166_L1.4121.00
44_L48_K1.4071.00
29_E33_L1.3911.00
218_F222_L1.3821.00
169_M195_T1.3751.00
205_I209_L1.3621.00
165_L206_S1.3301.00
86_R174_K1.3251.00
73_Q210_R1.3211.00
180_S194_I1.2671.00
220_L224_L1.2661.00
78_F203_I1.2661.00
234_T237_Y1.2651.00
174_K178_Y1.2631.00
238_D241_T1.2581.00
233_T241_T1.2541.00
82_S169_M1.2371.00
175_E178_Y1.2361.00
236_I239_L1.2321.00
152_A224_L1.2181.00
172_I198_N1.2011.00
47_Y255_T1.1971.00
71_A75_A1.1871.00
117_F148_V1.1841.00
186_G190_R1.1831.00
68_G71_A1.1821.00
93_A96_T1.1631.00
227_E230_P1.1491.00
158_T162_A1.1441.00
54_N57_S1.1431.00
17_A21_S1.1421.00
61_N64_V1.1411.00
149_V221_P1.1291.00
241_T245_P1.1251.00
200_R204_G1.1101.00
146_L150_M1.1001.00
49_E52_Y1.0901.00
85_S169_M1.0841.00
30_A255_T1.0821.00
74_L203_I1.0811.00
69_A153_D1.0621.00
164_I206_S1.0601.00
72_I150_M1.0591.00
93_A97_I1.0561.00
198_N201_S1.0531.00
267_I271_L1.0511.00
165_L202_F1.0451.00
233_T238_D1.0381.00
79_L83_V1.0311.00
82_S191_F1.0301.00
150_M154_S1.0261.00
217_I221_P1.0251.00
68_G72_I1.0241.00
147_L151_I0.9971.00
185_A190_R0.9931.00
217_I220_L0.9911.00
177_Y187_P0.9841.00
10_L14_P0.9831.00
46_N248_G0.9821.00
91_K170_S0.9791.00
153_D214_E0.9781.00
55_L253_S0.9751.00
190_R193_Y0.9741.00
69_A73_Q0.9721.00
63_I67_I0.9601.00
38_P41_G0.9591.00
61_N146_L0.9521.00
115_F119_T0.9511.00
9_F13_L0.9471.00
89_F92_R0.9471.00
64_V147_L0.9431.00
33_L251_L0.9431.00
82_S187_P0.9381.00
10_L13_L0.9341.00
81_A85_S0.9281.00
67_I71_A0.9281.00
29_E32_Y0.9251.00
12_V16_L0.9131.00
62_T235_L0.9121.00
99_I163_L0.9121.00
242_T246_E0.9091.00
165_L199_L0.9081.00
113_F152_A0.9071.00
59_I63_I0.9051.00
200_R203_I0.9041.00
33_L36_Q0.9021.00
113_F224_L0.8951.00
71_A207_L0.8951.00
77_G162_A0.8941.00
199_L202_F0.8931.00
168_G199_L0.8881.00
64_V67_I0.8801.00
50_L256_I0.8801.00
65_V146_L0.8761.00
152_A220_L0.8761.00
69_A150_M0.8651.00
123_Y147_L0.8621.00
225_I230_P0.8561.00
20_I24_F0.8551.00
81_A162_A0.8511.00
192_F196_L0.8481.00
73_Q77_G0.8471.00
35_F42_F0.8461.00
191_F196_L0.8401.00
106_T156_K0.8391.00
83_V88_F0.8371.00
161_V165_L0.8351.00
185_A193_Y0.8301.00
68_G154_S0.8261.00
72_I75_A0.8261.00
30_A251_L0.8261.00
261_I265_S0.8251.00
81_A169_M0.8201.00
92_R95_S0.8201.00
147_L150_M0.8161.00
190_R195_T0.8161.00
114_S118_Q0.8061.00
267_I270_K0.7911.00
84_L95_S0.7881.00
210_R214_E0.7871.00
70_L211_G0.7821.00
58_A61_N0.7811.00
44_L47_Y0.7811.00
60_I63_I0.7791.00
65_V153_D0.7781.00
145_S148_V0.7751.00
73_Q157_N0.7741.00
242_T245_P0.7711.00
148_V152_A0.7681.00
110_A219_A0.7681.00
249_L253_S0.7661.00
263_V267_I0.7651.00
33_L37_D0.7631.00
146_L230_P0.7611.00
84_L94_L0.7551.00
14_P17_A0.7551.00
73_Q161_V0.7531.00
99_I102_M0.7511.00
74_L165_L0.7501.00
77_G165_L0.7481.00
165_L169_M0.7451.00
37_D41_G0.7451.00
238_D253_S0.7431.00
110_A223_I0.7391.00
66_T70_L0.7371.00
49_E246_E0.7351.00
233_T237_Y0.7321.00
176_L194_I0.7311.00
187_P191_F0.7311.00
149_V225_I0.7301.00
25_F28_I0.7251.00
191_F195_T0.7251.00
37_D40_G0.7241.00
231_L239_L0.7241.00
122_G125_N0.7221.00
236_I240_Y0.7211.00
35_F43_S0.7181.00
11_L15_A0.7161.00
174_K181_A0.7111.00
232_L236_I0.7081.00
237_Y240_Y0.7071.00
200_R271_L0.7071.00
247_V250_A0.7061.00
30_A254_A0.7031.00
36_Q39_H0.7021.00
268_V271_L0.6981.00
221_P234_T0.6981.00
80_V158_T0.6971.00
172_I199_L0.6941.00
157_N210_R0.6941.00
179_A183_D0.6901.00
11_L14_P0.6901.00
84_L166_L0.6861.00
46_N49_E0.6851.00
19_V23_A0.6851.00
247_V251_L0.6841.00
56_S59_I0.6831.00
42_F45_Y0.6791.00
58_A238_D0.6781.00
243_T250_A0.6741.00
76_L154_S0.6721.00
106_T219_A0.6721.00
20_I23_A0.6721.00
109_A155_W0.6711.00
237_Y241_T0.6691.00
26_P30_A0.6681.00
16_L20_I0.6651.00
203_I206_S0.6631.00
241_T244_F0.6551.00
50_L249_L0.6541.00
41_G44_L0.6511.00
36_Q41_G0.6491.00
87_E92_R0.6491.00
95_S163_L0.6481.00
195_T198_N0.6471.00
50_L253_S0.6441.00
125_N227_E0.6431.00
73_Q214_E0.6431.00
47_Y252_A0.6421.00
70_L74_L0.6401.00
34_S252_A0.6381.00
251_L255_T0.6371.00
225_I229_P0.6351.00
102_M159_P0.6331.00
203_I207_L0.6261.00
80_V98_T0.6221.00
179_A182_I0.6211.00
52_Y56_S0.6211.00
117_F124_A0.6201.00
148_V224_L0.6201.00
62_T215_F0.6181.00
157_N213_Q0.6151.00
118_Q124_A0.6151.00
149_V153_D0.6131.00
251_L254_A0.6131.00
88_F94_L0.6131.00
65_V150_M0.6131.00
228_H231_L0.6121.00
15_A19_V0.6111.00
202_F206_S0.6091.00
65_V149_V0.6081.00
186_G192_F0.6041.00
39_H42_F0.6011.00
107_V223_I0.5981.00
51_S54_N0.5981.00
9_F12_V0.5961.00
73_Q154_S0.5921.00
190_R194_I0.5921.00
98_T159_P0.5911.00
145_S233_T0.5911.00
257_L261_I0.5881.00
164_I202_F0.5861.00
116_V124_A0.5821.00
222_L237_Y0.5821.00
53_F56_S0.5811.00
249_L252_A0.5811.00
262_L266_G0.5791.00
34_S255_T0.5791.00
115_F118_Q0.5771.00
236_I242_T0.5771.00
41_G45_Y0.5751.00
31_V35_F0.5751.00
43_S47_Y0.5741.00
212_V216_N0.5731.00
248_G251_L0.5731.00
218_F240_Y0.5711.00
69_A154_S0.5691.00
70_L214_E0.5681.00
90_G94_L0.5681.00
81_A166_L0.5671.00
234_T238_D0.5631.00
31_V34_S0.5631.00
225_I231_L0.5621.00
66_T215_F0.5611.00
234_T239_L0.5611.00
204_G207_L0.5601.00
66_T214_E0.5571.00
113_F116_V0.5561.00
153_D217_I0.5561.00
82_S195_T0.5551.00
217_I234_T0.5541.00
102_M160_I0.5541.00
65_V232_L0.5531.00
92_R96_T0.5521.00
240_Y244_F0.5491.00
242_T253_S0.5491.00
219_A222_L0.5461.00
76_L158_T0.5451.00
21_S25_F0.5441.00
195_T199_L0.5441.00
74_L78_F0.5411.00
242_T249_L0.5391.00
96_T100_I0.5341.00
26_P31_V0.5341.00
94_L98_T0.5331.00
87_E174_K0.5321.00
219_A223_I0.5321.00
213_Q216_N0.5311.00
13_L16_L0.5311.00
62_T234_T0.5291.00
192_F195_T0.5291.00
178_Y181_A0.5281.00
260_F263_V0.5281.00
153_D221_P0.5261.00
38_P42_F0.5261.00
89_F93_A0.5241.00
207_L210_R0.5241.00
65_V69_A0.5231.00
240_Y243_T0.5221.00
101_P159_P0.5221.00
80_V83_V0.5211.00
229_P233_T0.5201.00
172_I177_Y0.5191.00
36_Q40_G0.5171.00
145_S232_L0.5171.00
73_Q158_T0.5111.00
84_L88_F0.5101.00
53_F57_S0.5091.00
214_E217_I0.5061.00
206_S210_R0.5051.00
52_Y249_L0.5041.00
59_I256_I0.5021.00
34_S37_D0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tquM 1 0.9782 100 0.285 Contact Map
2onkC 2 0.9018 100 0.303 Contact Map
3rlfF 1 0.9564 100 0.319 Contact Map
3d31C 2 0.8909 100 0.324 Contact Map
3rlfG 1 0.9236 100 0.337 Contact Map
4tquN 1 0.8982 100 0.36 Contact Map
4ymuD 2 0.7745 99.9 0.472 Contact Map
3tuiA 2 0.7491 99.9 0.502 Contact Map
2k1eA 3 0.3236 9.3 0.946 Contact Map
1iijA 1 0.1236 4.7 0.953 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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